Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:E4 5.685410
2L:L:Q6 7.638520
3L:L:H14 8.135400
4L:L:V31 8.74460
5R:R:I115 8.5075465
6R:R:Y134 6.89667695
7R:R:R146 15.394108
8R:R:D149 4.9225405
9R:R:W154 6.9409
10R:R:Y167 6.22714765
11R:R:F184 7.575426
12R:R:Y191 4.7325417
13R:R:Y195 7.89833617
14R:R:F212 8.23254127
15R:R:T218 6.365447
16R:R:R219 4.744549
17R:R:N220 6.0475449
18R:R:H223 5.945449
19R:R:H225 11.6975418
20R:R:F227 3.9545119
21R:R:F230 7.87618
22R:R:R233 7.826518
23R:R:Y245 8.21484
24R:R:F288 4.56407
25R:R:Y290 5.066519
26R:R:Y296 8.22477
27R:R:Y297 6.9575406
28R:R:W298 10.2986719
29R:R:L300 5.4975408
30R:R:E302 10.1025409
31R:R:Y305 6.07667648
32R:R:H307 10.9375458
33R:R:F311 7.208556
34R:R:F315 9.115406
35R:R:W329 8.02167619
36R:R:P332 4.84409
37R:R:W339 5.82714738
38R:R:R343 8.188538
39R:R:C351 4.6925439
40R:R:W352 7.025638
41R:R:K360 6.6725437
42R:R:F378 6.8945139
43R:R:L389 2.7675408
44R:R:Q402 5.69406
45R:R:L406 2.215408
46R:R:F417 6.675409
47R:R:Y421 9.564508
48R:R:W437 8.24667625
49R:R:M441 8.63167626
50R:R:F450 5.048517
51R:R:Y459 8.49408
52R:R:E469 8.86754129
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H9 L:L:I5 17.06173.98NoNo000
2L:L:H9 R:R:Y429 34.56248.71NoNo006
3L:L:Q6 R:R:Y429 23.493713.53YesNo006
4L:L:I5 R:R:Q364 16.5419.61NoNo007
5R:R:Q364 R:R:Y429 17.726310.15NoNo076
6L:L:Q6 R:R:M441 14.88726.8YesYes206
7L:L:E4 R:R:M445 13.66236.77YesNo006
8L:L:L7 R:R:M445 12.28374.24NoNo006
9L:L:E4 R:R:Y195 10.88778.98YesYes107
10R:R:N448 R:R:R233 10.30993.62NoYes068
11L:L:E4 R:R:R233 55.23183.49YesYes108
12L:L:E4 R:R:F288 58.40323.5YesYes007
13R:R:F184 R:R:W437 12.43244.01YesYes265
14L:L:H9 R:R:K360 50.555410.48NoYes007
15L:L:H14 R:R:F184 10.116510.18YesYes006
16R:R:C351 R:R:Y278 10.81334.03YesNo394
17R:R:C351 R:R:R282 99.53382.79YesNo398
18R:R:R282 R:R:W352 10012NoYes388
19R:R:W339 R:R:W352 76.63283.75YesYes388
20R:R:K360 R:R:W339 26.55846.96YesYes378
21R:R:R343 R:R:W352 25.254211YesYes388
22R:R:K360 R:R:R343 25.25426.19YesYes378
23L:L:N16 R:R:L354 88.93136.87NoNo005
24R:R:D353 R:R:L354 90.50835.43NoNo055
25R:R:C351 R:R:D353 91.28944.67YesNo095
26L:L:N16 L:L:R20 88.13546.03NoNo000
27L:L:R20 R:R:Q37 85.735210.51NoNo007
28L:L:D30 L:L:K27 79.11236.91NoNo000
29L:L:K27 L:L:L24 79.96282.82NoNo000
30L:L:L24 L:L:W23 83.28793.42NoNo000
31L:L:W23 R:R:Q37 84.93681.1NoNo007
32L:L:V31 R:R:D113 22.23165.84YesNo609
33L:L:F34 R:R:D113 73.905311.94NoNo009
34L:L:F34 R:R:H114 74.785516.97NoNo004
35L:L:D30 R:R:H114 75.660825.21NoNo004
36R:R:D113 R:R:Y167 50.77614.6NoYes695
37L:L:V31 R:R:I115 20.161215.36YesYes605
38R:R:I115 R:R:Y167 21.42577.25YesYes655
39R:R:C170 R:R:Y167 27.92965.38NoYes095
40R:R:C131 R:R:C170 26.87087.28NoNo099
41R:R:C131 R:R:F138 17.11885.59NoNo094
42R:R:F138 R:R:I135 13.778810.05NoNo047
43R:R:I135 R:R:Y134 11.502612.09NoYes975
44R:R:I115 R:R:L116 39.49677.14YesNo055
45R:R:L116 R:R:V129 37.34444.47NoNo055
46R:R:V129 R:R:W118 33.02513.48NoNo059
47R:R:R146 R:R:W118 28.653633.99YesNo1089
48R:R:R146 R:R:W154 24.32685YesYes089
49R:R:S153 R:R:W154 17.75112.47NoYes049
50R:R:D149 R:R:S153 15.54921.47YesNo054
51R:R:S449 R:R:Y195 13.90785.09NoYes197
52R:R:F450 R:R:S449 10.22567.93YesNo179
53R:R:F230 R:R:R233 47.54776.41YesYes188
54R:R:F230 R:R:L226 35.2076.09YesNo089
55R:R:E302 R:R:L226 34.82526.63YesNo099
56R:R:E302 R:R:H223 27.406411.08YesYes099
57R:R:H223 R:R:R219 14.74344.51YesYes499
58R:R:E465 R:R:R219 15.01613.49NoYes099
59R:R:E465 R:R:N463 14.17063.94NoNo099
60R:R:N463 R:R:V466 11.604310.35NoNo099
61R:R:L215 R:R:V466 10.73894.47NoNo099
62R:R:E302 R:R:I222 16.29315.47YesNo099
63R:R:I222 R:R:Y305 18.14783.63NoYes098
64R:R:N295 R:R:R233 24.438413.26NoYes188
65R:R:N295 R:R:S229 28.48255.96NoNo189
66R:R:S229 R:R:W298 12.76967.41NoYes199
67R:R:I222 R:R:W298 19.82643.52NoYes099
68R:R:S229 R:R:W329 15.30873.71NoYes199
69R:R:H223 R:R:Y459 11.59934.36YesYes098
70R:R:F230 R:R:I299 17.45353.77YesNo189
71R:R:L289 R:R:W339 58.1856.83NoYes078
72R:R:Q364 R:R:W361 31.54488.76NoNo078
73R:R:V365 R:R:W361 28.54954.9NoNo058
74R:R:P366 R:R:V365 27.25273.53NoNo095
75R:R:F335 R:R:P366 26.412115.89NoNo059
76R:R:F335 R:R:Y297 25.6986.19NoYes056
77R:R:P332 R:R:Y297 13.4498.34YesYes096
78R:R:P332 R:R:T294 15.76255.25YesNo098
79R:R:T294 R:R:W329 16.1277.28NoYes189
80R:R:S370 R:R:Y297 27.78585.09NoYes076
81R:R:I299 R:R:N374 18.81735.66NoNo099
82R:R:L300 R:R:S370 25.96584.5YesNo087
83R:R:L300 R:R:L304 22.40276.92YesNo085
84R:R:F417 R:R:N374 18.10568.46YesNo099
85R:R:L304 R:R:L377 20.56294.15NoNo057
86R:R:H307 R:R:L377 16.868311.57YesNo087
87R:R:F378 R:R:T410 17.87013.89YesNo1399
88R:R:F378 R:R:L413 11.03643.65YesNo099
89R:R:L406 R:R:T410 16.89812.95YesNo089
90R:R:L389 R:R:L406 12.75731.38YesYes088
91R:R:R233 R:R:Y195 10.828212.35YesYes187
92R:R:F378 R:R:F417 16.47418.57YesYes099
93R:R:F288 R:R:L289 58.41313.65YesNo077
94R:R:L413 R:R:Y459 11.57953.52NoYes098
95R:R:W298 R:R:W329 11.123223.43YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:V2 R:R:Y296 5.05 7 No Yes 0 7 0 1
L:L:V2 R:R:I367 4.61 7 No No 0 7 0 1
L:L:S3 R:R:Q440 5.78 2 No No 0 6 0 1
L:L:S3 R:R:M441 6.13 2 No Yes 0 6 0 1
L:L:S3 R:R:E444 14.37 2 No No 0 7 0 1
L:L:E4 R:R:Y195 8.98 1 Yes Yes 0 7 0 1
L:L:E4 R:R:R233 3.49 1 Yes Yes 0 8 0 1
L:L:E4 R:R:F288 3.5 1 Yes Yes 0 7 0 1
L:L:E4 R:R:M445 6.77 1 Yes No 0 6 0 1
L:L:I5 R:R:Q364 9.61 0 No No 0 7 0 1
L:L:Q6 R:R:Y429 13.53 2 Yes No 0 6 0 1
L:L:Q6 R:R:W437 5.48 2 Yes Yes 0 5 0 1
L:L:Q6 R:R:M441 6.8 2 Yes Yes 0 6 0 1
L:L:L7 R:R:L187 4.15 2 No No 0 5 0 1
L:L:L7 R:R:M441 7.07 2 No Yes 0 6 0 1
L:L:L7 R:R:M445 4.24 2 No No 0 6 0 1
L:L:M8 R:R:K240 4.32 0 No No 0 7 0 1
L:L:M8 R:R:V285 4.56 0 No No 0 6 0 1
L:L:M8 R:R:F288 6.22 0 No Yes 0 7 0 1
L:L:H9 R:R:K360 10.48 0 No Yes 0 7 0 1
L:L:H9 R:R:Y429 8.71 0 No No 0 6 0 1
L:L:N10 R:R:W437 10.17 2 No Yes 0 5 0 1
L:L:L11 R:R:F184 12.18 0 No Yes 0 6 0 1
L:L:L11 R:R:Y245 9.38 0 No Yes 0 4 0 1
L:L:H14 R:R:R181 6.77 0 Yes No 0 3 0 1
L:L:H14 R:R:F184 10.18 0 Yes Yes 0 6 0 1
L:L:N16 R:R:L354 6.87 0 No No 0 5 0 1
L:L:E19 R:R:K34 13.5 0 No No 0 4 0 1
L:L:R20 R:R:Q37 10.51 0 No No 0 7 0 1
L:L:W23 R:R:I38 4.7 0 No No 0 7 0 1
L:L:L24 R:R:D137 6.79 0 No No 0 5 0 1
L:L:L28 R:R:I115 4.28 6 No Yes 0 5 0 1
L:L:L28 R:R:Y167 9.38 6 No Yes 0 5 0 1
L:L:D30 R:R:H114 25.21 0 No No 0 4 0 1
L:L:V31 R:R:D113 5.84 6 Yes No 0 9 0 1
L:L:V31 R:R:I115 15.36 6 Yes Yes 0 5 0 1
L:L:V31 R:R:Y167 6.31 6 Yes Yes 0 5 0 1
L:L:F34 R:R:D113 11.94 0 No No 0 9 0 1
L:L:F34 R:R:H114 16.97 0 No No 0 4 0 1
R:R:M32 R:R:Y136 23.95 0 No No 6 4 2 1
R:R:E35 R:R:K34 4.05 0 No No 5 4 2 1
R:R:D113 R:R:Y167 4.6 6 No Yes 9 5 1 1
R:R:I115 R:R:L116 7.14 6 Yes No 5 5 1 2
R:R:I115 R:R:Y167 7.25 6 Yes Yes 5 5 1 1
R:R:D137 R:R:L174 6.79 0 No No 5 3 1 2
R:R:A144 R:R:Y167 4 0 No Yes 7 5 2 1
R:R:A165 R:R:Y167 6.67 0 No Yes 7 5 2 1
R:R:C170 R:R:Y167 5.38 0 No Yes 9 5 2 1
R:R:D185 R:R:R181 4.76 0 No No 2 3 2 1
R:R:F184 R:R:V432 3.93 2 Yes No 6 5 1 2
R:R:F184 R:R:W437 4.01 2 Yes Yes 6 5 1 1
R:R:L187 R:R:M441 4.24 2 No Yes 5 6 1 1
R:R:H442 R:R:L187 6.43 0 No No 5 5 2 1
R:R:Y191 R:R:Y195 5.96 1 Yes Yes 7 7 2 1
R:R:I237 R:R:Y191 3.63 1 No Yes 7 7 2 2
R:R:R233 R:R:Y195 12.35 1 Yes Yes 8 7 1 1
R:R:A234 R:R:Y195 5.34 0 No Yes 8 7 2 1
R:R:I237 R:R:Y195 9.67 1 No Yes 7 7 2 1
R:R:S449 R:R:Y195 5.09 1 No Yes 9 7 2 1
R:R:F230 R:R:R233 6.41 1 Yes Yes 8 8 2 1
R:R:F230 R:R:N295 21.75 1 Yes No 8 8 2 2
R:R:N295 R:R:R233 13.26 1 No Yes 8 8 2 1
R:R:N448 R:R:R233 3.62 0 No Yes 6 8 2 1
R:R:K240 R:R:L244 4.23 8 No No 7 5 1 2
R:R:K240 R:R:Y245 9.55 8 No Yes 7 4 1 1
R:R:D241 R:R:Y245 8.05 0 No Yes 8 4 2 1
R:R:L244 R:R:Y245 5.86 8 No Yes 5 4 2 1
R:R:F288 R:R:L289 3.65 0 Yes No 7 7 1 2
R:R:F288 R:R:L292 4.87 0 Yes No 7 6 1 2
R:R:L289 R:R:W339 6.83 0 No Yes 7 8 2 2
R:R:L292 R:R:Y296 4.69 0 No Yes 6 7 2 1
R:R:I367 R:R:Y296 7.25 7 No Yes 7 7 1 1
R:R:Y296 R:R:Y421 15.89 7 Yes Yes 7 8 1 2
R:R:R343 R:R:W339 9 3 Yes Yes 8 8 2 2
R:R:K360 R:R:W339 6.96 3 Yes Yes 7 8 1 2
R:R:K360 R:R:R343 6.19 3 Yes Yes 7 8 1 2
R:R:D353 R:R:L354 5.43 0 No No 5 5 2 1
R:R:Q364 R:R:W361 8.76 0 No No 7 8 1 2
R:R:Q364 R:R:Y429 10.15 0 No No 7 6 1 1
R:R:N448 R:R:Y421 9.3 0 No Yes 6 8 2 2
R:R:F424 R:R:Q440 11.71 0 No No 7 6 2 1
R:R:P428 R:R:T427 3.5 0 No No 7 5 2 1
R:R:T430 R:R:W437 7.28 0 No Yes 5 5 2 1
R:R:V432 R:R:W437 8.58 2 No Yes 5 5 2 1
R:R:M441 R:R:W437 13.96 2 Yes Yes 6 5 1 1
R:R:M441 R:R:Q440 13.59 2 Yes No 6 6 1 1
R:R:E444 R:R:N448 9.2 0 No No 7 6 1 2
L:L:G12 R:R:L354 3.42 0 No No 0 5 0 1
L:L:S1 R:R:T427 3.2 0 No No 0 5 0 1
R:R:K360 R:R:S355 3.06 3 Yes No 7 7 1 2
R:R:L436 R:R:T427 2.95 0 No No 4 5 2 1
R:R:L436 R:R:T430 2.95 0 No No 4 5 2 2
R:R:I190 R:R:M445 2.92 0 No No 6 6 2 1
L:L:H14 R:R:E180 2.46 0 Yes No 0 3 0 1
L:L:R20 R:R:Y136 2.06 0 No No 0 4 0 1
R:R:E180 R:R:R179 1.16 0 No No 3 3 1 2
L:L:W23 R:R:Q37 1.1 0 No No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7VVK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.49
Number of Linked Nodes 332
Number of Links 380
Number of Hubs 52
Number of Links mediated by Hubs 205
Number of Communities 13
Number of Nodes involved in Communities 79
Number of Links involved in Communities 103
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 84096
Length Of Smallest Path 3
Average Path Length 19.4924
Length of Longest Path 47
Minimum Path Strength 1.33
Average Path Strength 7.2153
Maximum Path Strength 23.735
Minimum Path Correlation 0.7
Average Path Correlation 0.959995
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 62.4169
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.8892
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body   • G-protein beta-subunit binding   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • parathyroid hormone receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • type 1 parathyroid hormone receptor binding   • molecular transducer activity   • molecular function activator activity   • signaling receptor activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • peptide hormone receptor binding   • hormone receptor binding   • hormone activity   • response to xenobiotic stimulus   • response to parathyroid hormone   • magnesium ion homeostasis   • inorganic ion homeostasis   • chemical homeostasis   • homeostatic process   • monoatomic ion homeostasis   • monoatomic cation homeostasis   • ossification   • bone mineralization   • biomineral tissue development   • tissue development   • multicellular organismal-level homeostasis   • homeostasis of number of cells within a tissue   • anatomical structure homeostasis   • tissue homeostasis   • homeostasis of number of cells   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • macromolecule biosynthetic process   • skeletal system development   • regulation of biosynthetic process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • RNA metabolic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • RNA biosynthetic process   • nucleobase-containing compound metabolic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • transcription by RNA polymerase II   • negative regulation of apoptotic process in bone marrow cell   • negative regulation of programmed cell death   • apoptotic process in bone marrow cell   • regulation of apoptotic process in bone marrow cell   • regulation of apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • negative regulation of apoptotic process   • negative regulation of cellular process   • regulation of generation of precursor metabolites and energy   • regulation of primary metabolic process   • positive regulation of glycogen metabolic process   • regulation of small molecule metabolic process   • small molecule metabolic process   • carbohydrate biosynthetic process   • hexose metabolic process   • positive regulation of glucose metabolic process   • positive regulation of glycogen biosynthetic process   • energy reserve metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of glycogen metabolic process   • monosaccharide metabolic process   • regulation of glycogen biosynthetic process   • glucan biosynthetic process   • energy derivation by oxidation of organic compounds   • regulation of glucan biosynthetic process   • regulation of polysaccharide metabolic process   • polysaccharide metabolic process   • glucan metabolic process   • regulation of carbohydrate metabolic process   • regulation of glucose metabolic process   • carbohydrate metabolic process   • polysaccharide biosynthetic process   • glycogen metabolic process   • generation of precursor metabolites and energy   • glycogen biosynthetic process   • regulation of polysaccharide biosynthetic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • glucose metabolic process   • phosphate ion homeostasis   • cell-cell signaling   • intracellular calcium ion homeostasis   • calcium ion homeostasis   • cellular homeostasis   • intracellular monoatomic cation homeostasis   • intracellular chemical homeostasis   • intracellular monoatomic ion homeostasis   • regulation of developmental process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • positive regulation of biomineral tissue development   • regulation of multicellular organismal process   • regulation of multicellular organismal development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • response to ethanol   • response to metal ion   • response to lead ion   • positive regulation of cell population proliferation   • positive regulation of cell proliferation in bone marrow   • cell proliferation in bone marrow   • regulation of cell proliferation in bone marrow   • regulation of cell population proliferation   • response to nutrient levels   • response to vitamin D   • response to nutrient   • response to vitamin   • hormone-mediated signaling pathway   • apoptotic signaling pathway   • hormone-mediated apoptotic signaling pathway   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • cAMP metabolic process   • cyclic purine nucleotide metabolic process   • carbohydrate derivative metabolic process   • nucleotide metabolic process   • cyclic nucleotide metabolic process   • purine-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • phosphate-containing compound metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • regulation of cartilage development   • regulation of chondrocyte differentiation   • connective tissue development   • cellular developmental process   • negative regulation of cartilage development   • negative regulation of chondrocyte differentiation   • regulation of cell differentiation   • cell differentiation   • negative regulation of cell differentiation   • negative regulation of developmental process   • chondrocyte differentiation   • negative regulation of multicellular organismal process   • cartilage development   • negative regulation of metabolic process   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of macromolecule metabolic process   • regulation of localization   • hexose transmembrane transport   • D-glucose import   • transport   • carbohydrate transport   • positive regulation of D-glucose transmembrane transport   • localization   • positive regulation of transmembrane transport   • regulation of D-glucose import   • positive regulation of D-glucose import   • regulation of transport   • establishment of localization   • transmembrane transport   • regulation of transmembrane transport   • positive regulation of transport   • D-glucose transmembrane transport   • regulation of D-glucose transmembrane transport   • monosaccharide transmembrane transport   • carbohydrate transmembrane transport   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • response to cadmium ion   • small GTPase-mediated signal transduction   • Rho protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • regulation of leukocyte proliferation   • osteoclast proliferation   • regulation of osteoclast proliferation   • positive regulation of osteoclast proliferation   • leukocyte proliferation   • positive regulation of leukocyte proliferation   • bone maturation   • regulation of bone mineralization involved in bone maturation   • negative regulation of biomineral tissue development   • negative regulation of bone mineralization   • ossification involved in bone maturation   • bone development   • bone mineralization involved in bone maturation   • developmental maturation   • negative regulation of bone mineralization involved in bone maturation   • negative regulation of ossification   • anatomical structure maturation   • animal organ maturation   • positive regulation of DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • positive regulation of transcription by RNA polymerase II   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of phosphate metabolic process   • polyol biosynthetic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of alcohol biosynthetic process   • tissue remodeling   • bone remodeling   • bone resorption   • response to fibroblast growth factor   • response to growth factor   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • parathyroid hormone receptor activity   • osteoblast development   • cell development   • osteoblast differentiation   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • cell maturation   • cell surface receptor signaling pathway   • negative regulation of cell population proliferation   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • apical part of cell   • apical plasma membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ03431
Sequence
>7VVK_nogp_Chain_R
VMTKEEQIF LLHRAQAQC EEWDHILCW VAVPCPDYI YDFNHKGHA 
YRRCDRNGS WELVTWANY SECVKFLRE REVFDRLGM IYTVGYSVS 
LASLTVAVL ILAYFRRLH CTRNYIHMH LFLSFMLRA VSIFVKDAV 
LYSYAGCRV AVTFFLYFL ATNYYWILV EGLYLHSLI FMAFFSEKK 
YLWGFTVFG WGLPAVFVA VWVSVRATL ANTGCWDLS SGNKKWIIQ 
VPILASIVL NFILFINIV RVLATKLRE TDTRQQYRK LLKSTLVLM 
PLFGVHYIV FMATPYTEV SGTLWQVQM HYEMLFNSF QGFFVAIIY 
CFCNGEVQA EIKKSWSRW T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR3 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR2 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-0210.1038/s41586-023-06467-w
8JR9 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-PCO3712.572023-08-0210.1038/s41586-023-06467-w
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-Gs/β1/γ22.82023-07-05To be published
7Y36 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-2.82023-07-05To be published
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
7Y35 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-2.92023-07-05To be published
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-KHFGs/β1/γ22.92023-06-1410.1038/s41586-023-06169-3
8GW8 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-KHF2.92023-06-1410.1038/s41586-023-06169-3
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-Gs/β1/γ22.762023-04-2610.1016/j.str.2023.04.002
8FLU (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-2.762023-04-2610.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-2610.1016/j.str.2023.04.002
8FLT (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-3.032023-04-2610.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-2610.1016/j.str.2023.04.002
8FLS (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-3.092023-04-2610.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-2610.1016/j.str.2023.04.002
8FLR (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-2.942023-04-2610.1016/j.str.2023.04.002
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-2610.1016/j.str.2023.04.002
8FLQ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.552023-04-2610.1016/j.str.2023.04.002
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-2110.1038/s41401-022-01032-z
8HAO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.762022-12-2110.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-2110.1038/s41401-022-01032-z
8HAF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.252022-12-2110.1038/s41401-022-01032-z
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-2110.1038/s41401-022-01032-z
8HA0 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.622022-12-2110.1038/s41401-022-01032-z
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-0310.1016/j.molcel.2022.07.003
7VVO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-4.12022-08-0310.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-0310.1016/j.molcel.2022.07.003
7VVN (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.82022-08-0310.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVM (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.22022-08-0310.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-0310.1016/j.molcel.2022.07.003
7VVL (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82022-08-0310.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-0310.1016/j.molcel.2022.07.003
7VVK (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.32022-08-0310.1016/j.molcel.2022.07.003
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVJ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.22022-08-0310.1016/j.molcel.2022.07.003
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ242019-04-1710.1126/science.aav7942
6NBI (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-42019-04-1710.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ23.52019-04-1710.1126/science.aav7942
6NBH (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-3.52019-04-1710.1126/science.aav7942
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ232019-04-1710.1126/science.aav7942
6NBF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-32019-04-1710.1126/science.aav7942
6FJ3B1PeptideParathyroid HormonePTH1Homo sapiensPTH--2.52018-11-2110.1038/s41594-018-0151-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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