psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E36	R:R:M32	5.41	No	Yes	0	6	6
2	R:R:M32	R:R:Q37	5.44	Yes	Yes	0	6	7
3	R:R:M32	R:R:Y136	9.58	Yes	No	8	6	4
4	L:L:R20	R:R:M32	9.93	Yes	Yes	8	0	6
5	R:R:E35	R:R:T33	4.23	No	No	0	5	7
6	L:L:Q16	R:R:T33	4.25	No	No	0	0	7
7	R:R:I38	R:R:K34	2.91	No	No	10	7	4
8	L:L:L23	R:R:K34	2.82	Yes	No	10	0	4
9	R:R:L40	R:R:Q37	2.66	No	Yes	0	5	7
10	R:R:I135	R:R:Q37	2.74	Yes	Yes	0	7	7
11	L:L:L23	R:R:Q37	2.66	Yes	Yes	0	0	7
12	L:L:L23	R:R:I38	2.85	Yes	No	10	0	7
13	R:R:F39	R:R:R43	9.62	No	No	0	7	4
14	R:R:H42	R:R:R43	9.03	No	No	0	4	4
15	R:R:A44	R:R:Y134	8.01	No	Yes	0	7	5
16	R:R:E49	R:R:Q45	7.65	No	No	0	6	7
17	R:R:Q45	R:R:W112	20.81	No	Yes	0	7	7
18	R:R:K50	R:R:Q47	2.71	No	No	0	4	6
19	R:R:C48	R:R:W112	5.22	No	Yes	0	8	7
20	R:R:C117	R:R:C48	7.28	No	No	0	9	8
21	R:R:K50	R:R:R51	3.71	No	No	0	4	6
22	R:R:E54	R:R:R51	11.63	No	No	0	6	6
23	R:R:L109	R:R:L52	2.77	Yes	No	5	5	4
24	R:R:L52	R:R:P110	4.93	No	Yes	5	4	6
25	R:R:L109	R:R:V55	2.98	Yes	No	5	5	5
26	R:R:P110	R:R:V55	10.6	Yes	No	5	6	5
27	R:R:L120	R:R:P107	9.85	No	No	0	4	3
28	R:R:C108	R:R:C148	7.28	No	No	0	9	9
29	R:R:C108	R:R:W154	16.98	No	No	0	9	9
30	R:R:L109	R:R:P110	3.28	Yes	Yes	5	5	6
31	R:R:L109	R:R:L120	2.77	Yes	No	5	5	4
32	R:R:L120	R:R:P110	3.28	No	Yes	5	4	6
33	R:R:W112	R:R:Y134	4.82	Yes	Yes	0	7	5
34	R:R:D113	R:R:I115	9.8	Yes	Yes	2	9	5
35	R:R:D113	R:R:L116	8.14	Yes	Yes	2	9	5
36	R:R:D113	R:R:W118	10.05	Yes	Yes	2	9	9
37	R:R:D113	R:R:Y167	8.05	Yes	Yes	2	9	5
38	R:R:I115	R:R:L116	5.71	Yes	Yes	2	5	5
39	R:R:I115	R:R:Y167	6.04	Yes	Yes	2	5	5
40	L:L:L27	R:R:I115	4.28	No	Yes	0	0	5
41	L:L:L31	R:R:I115	4.28	No	Yes	0	0	5
42	R:R:L116	R:R:W118	14.81	Yes	Yes	2	5	9
43	R:R:L116	R:R:V129	2.98	Yes	Yes	2	5	5
44	R:R:L116	R:R:P132	8.21	Yes	No	2	5	9
45	R:R:L116	R:R:Y167	3.52	Yes	Yes	2	5	5
46	R:R:P119	R:R:W118	2.7	No	Yes	2	6	9
47	R:R:V129	R:R:W118	6.13	Yes	Yes	2	5	9
48	R:R:A144	R:R:W118	3.89	No	Yes	2	7	9
49	R:R:R146	R:R:W118	26.99	No	Yes	0	8	9
50	R:R:W118	R:R:Y167	6.75	Yes	Yes	2	9	5
51	R:R:P119	R:R:V127	3.53	No	No	0	6	7
52	R:R:P119	R:R:V129	3.53	No	Yes	2	6	5
53	R:R:A122	R:R:E125	6.03	No	No	0	1	5
54	R:R:P123	R:R:R150	5.76	No	No	0	7	1
55	R:R:G124	R:R:R150	4.5	No	No	0	7	1
56	R:R:V127	R:R:W154	4.9	No	No	0	7	9
57	R:R:A128	R:R:H143	4.39	No	No	11	5	3
58	R:R:A128	R:R:Y145	4	No	No	11	5	4
59	R:R:P130	R:R:V129	3.53	No	Yes	0	5	5
60	R:R:H143	R:R:P130	9.15	No	No	0	3	5
61	R:R:C131	R:R:C170	7.28	No	No	0	9	9
62	R:R:P132	R:R:Y134	12.52	No	Yes	2	9	5
63	R:R:I135	R:R:P132	8.47	Yes	No	2	7	9
64	R:R:I135	R:R:Y134	3.63	Yes	Yes	2	7	5
65	R:R:F138	R:R:I135	20.09	Yes	Yes	2	4	7
66	L:L:L24	R:R:I135	4.28	No	Yes	0	0	7
67	R:R:D137	R:R:Y136	8.05	Yes	No	8	5	4
68	L:L:R20	R:R:Y136	13.38	Yes	No	8	0	4
69	R:R:D137	R:R:L174	2.71	Yes	No	0	5	3
70	L:L:R20	R:R:D137	13.1	Yes	Yes	8	0	5
71	L:L:L24	R:R:D137	4.07	No	Yes	0	0	5
72	R:R:C170	R:R:F138	6.98	No	Yes	0	9	4
73	R:R:F138	R:R:V171	5.24	Yes	No	2	4	3
74	L:L:L28	R:R:F138	4.87	No	Yes	2	0	4
75	R:R:K141	R:R:N139	4.2	No	No	0	3	4
76	R:R:F173	R:R:N139	16.92	No	No	0	3	4
77	R:R:H140	R:R:K141	10.48	No	No	0	3	3
78	R:R:E169	R:R:G142	3.27	No	No	0	5	5
79	R:R:H143	R:R:Y145	4.36	No	No	11	3	4
80	R:R:A144	R:R:Y167	2.67	No	Yes	2	7	5
81	R:R:E169	R:R:Y145	11.22	No	No	0	5	4
82	R:R:R146	R:R:W154	27.99	No	No	0	8	9
83	R:R:R146	R:R:T163	11.64	No	No	0	8	5
84	R:R:E155	R:R:R147	19.77	No	No	2	4	3
85	R:R:R147	R:R:W164	34.99	No	Yes	2	3	5
86	R:R:D149	R:R:N151	8.08	No	No	0	5	5
87	R:R:E155	R:R:W164	4.36	No	Yes	2	4	5
88	R:R:P158	R:R:V157	3.53	No	Yes	0	4	4
89	R:R:H160	R:R:V157	5.54	No	Yes	0	4	4
90	R:R:R162	R:R:V157	7.85	No	Yes	0	3	4
91	R:R:V157	R:R:W164	3.68	Yes	Yes	0	4	5
92	R:R:N166	R:R:W164	3.39	No	Yes	2	7	5
93	R:R:A165	R:R:Y167	5.34	No	Yes	0	7	5
94	R:R:N166	R:R:S168	7.45	No	No	2	7	6
95	L:L:H32	R:R:N166	5.1	Yes	No	2	0	7
96	L:L:H32	R:R:Y167	8.71	Yes	Yes	2	0	5
97	L:L:H32	R:R:S168	2.79	Yes	No	2	0	6
98	R:R:L174	R:R:V171	2.98	No	No	0	3	3
99	L:L:L28	R:R:V171	5.96	No	No	2	0	3
100	R:R:E180	R:R:T178	7.06	Yes	No	0	3	3
101	R:R:E180	R:R:V183	2.85	Yes	No	0	3	4
102	R:R:D185	R:R:E182	5.2	No	No	0	2	2
103	R:R:E182	R:R:R186	6.98	No	No	0	2	5
104	R:R:Q438	R:R:V183	5.73	No	No	0	4	4
105	R:R:F184	R:R:W437	6.01	Yes	Yes	0	6	5
106	L:L:L7	R:R:F184	4.87	Yes	Yes	0	0	6
107	L:L:K11	R:R:F184	11.17	No	Yes	0	0	6
108	R:R:H442	R:R:R186	6.77	No	No	0	5	5
109	R:R:L187	R:R:M441	5.65	Yes	Yes	1	5	6
110	R:R:H442	R:R:L187	5.14	No	Yes	0	5	5
111	R:R:L187	R:R:M445	2.83	Yes	Yes	1	5	6
112	L:L:L7	R:R:L187	4.15	Yes	Yes	1	0	5
113	R:R:A188	R:R:Y191	4	No	Yes	0	5	7
114	R:R:M189	R:R:V193	3.04	No	No	0	4	6
115	R:R:I190	R:R:L446	2.85	No	No	0	6	5
116	R:R:Y191	R:R:Y195	5.96	Yes	Yes	1	7	7
117	R:R:I237	R:R:Y191	3.63	No	Yes	1	7	7
118	R:R:D241	R:R:Y191	5.75	No	Yes	0	8	7
119	R:R:M445	R:R:Y191	5.99	Yes	Yes	1	6	7
120	R:R:F238	R:R:T192	5.19	No	No	0	7	7
121	R:R:G194	R:R:S449	3.71	No	No	1	9	9
122	R:R:F450	R:R:G194	9.03	No	No	1	7	9
123	R:R:R233	R:R:Y195	6.17	Yes	Yes	1	8	7
124	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
125	R:R:I237	R:R:Y195	7.25	No	Yes	1	7	7
126	R:R:F238	R:R:Y195	3.09	No	Yes	0	7	7
127	R:R:F238	R:R:S196	2.64	No	No	0	7	7
128	R:R:F453	R:R:V197	6.55	Yes	No	0	6	5
129	R:R:G452	R:R:S198	3.71	No	No	0	9	9
130	R:R:F453	R:R:S198	2.64	Yes	No	0	6	9
131	R:R:L199	R:R:M231	4.24	No	Yes	0	7	8
132	R:R:F453	R:R:S201	6.61	Yes	No	0	6	8
133	R:R:F227	R:R:L202	6.09	Yes	Yes	0	9	9
134	R:R:F230	R:R:L202	3.65	Yes	Yes	0	8	9
135	R:R:L202	R:R:M231	2.83	Yes	Yes	0	9	8
136	R:R:A456	R:R:L202	3.15	No	Yes	0	8	9
137	R:R:M231	R:R:T203	3.01	Yes	No	0	8	3
138	R:R:I208	R:R:V204	3.07	No	No	0	8	5
139	R:R:F461	R:R:V204	3.93	No	No	0	8	5
140	R:R:A205	R:R:F227	2.77	No	Yes	0	9	9
141	R:R:A205	R:R:C460	3.61	No	No	0	9	9
142	R:R:F227	R:R:V206	3.93	Yes	No	0	9	5
143	R:R:L228	R:R:V206	2.98	No	No	12	4	5
144	R:R:M231	R:R:V206	3.04	Yes	No	12	8	5
145	R:R:C460	R:R:I208	4.91	No	No	0	9	8
146	R:R:L209	R:R:N220	5.49	No	No	0	7	9
147	R:R:L209	R:R:M224	2.83	No	No	0	7	5
148	R:R:F227	R:R:L209	3.65	Yes	No	0	9	7
149	R:R:F212	R:R:Y211	6.19	Yes	No	0	7	2
150	R:R:F212	R:R:L215	4.87	Yes	No	13	7	9
151	R:R:E469	R:R:F212	15.16	Yes	Yes	13	9	7
152	R:R:F212	R:R:S473	2.64	Yes	No	0	7	4
153	R:R:H216	R:R:R213	6.77	No	No	0	8	8
154	R:R:E465	R:R:R214	10.47	No	No	0	9	7
155	R:R:E469	R:R:R214	8.14	Yes	No	0	9	7
156	R:R:L215	R:R:V466	5.96	No	No	0	9	9
157	R:R:E469	R:R:L215	2.65	Yes	No	13	9	9
158	R:R:H216	R:R:Y221	8.71	No	No	0	8	7
159	R:R:C217	R:R:N220	3.15	No	No	0	8	9
160	R:R:T218	R:R:Y305	6.24	No	Yes	6	7	8
161	R:R:E317	R:R:T218	8.47	No	No	6	6	7
162	R:R:L321	R:R:T218	2.95	No	No	0	6	7
163	R:R:N220	R:R:R219	3.62	No	No	0	9	9
164	R:R:H223	R:R:R219	4.51	No	No	0	9	9
165	R:R:E302	R:R:I222	5.47	Yes	No	0	9	9
166	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
167	R:R:I222	R:R:L321	2.85	No	No	0	9	6
168	R:R:E302	R:R:H223	9.85	Yes	No	0	9	9
169	R:R:H225	R:R:W298	16.93	No	Yes	4	8	9
170	R:R:H225	R:R:T325	5.48	No	No	0	8	5
171	R:R:H225	R:R:W329	6.35	No	No	4	8	9
172	R:R:F227	R:R:L226	3.65	Yes	Yes	0	9	9
173	R:R:F230	R:R:L226	6.09	Yes	Yes	0	8	9
174	R:R:I299	R:R:L226	2.85	No	Yes	0	9	9
175	R:R:E302	R:R:L226	14.58	Yes	Yes	0	9	9
176	R:R:F227	R:R:V455	3.93	Yes	Yes	0	9	9
177	R:R:L228	R:R:M231	4.24	No	Yes	12	4	8
178	R:R:N295	R:R:S229	7.45	No	No	0	8	9
179	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
180	R:R:F230	R:R:N295	18.12	Yes	No	0	8	8
181	R:R:F230	R:R:Q451	5.86	Yes	Yes	0	8	9
182	R:R:F230	R:R:G452	9.03	Yes	No	0	8	9
183	R:R:F230	R:R:V455	3.93	Yes	Yes	0	8	9
184	R:R:F291	R:R:L232	10.96	Yes	No	0	5	8
185	R:R:L292	R:R:R233	6.07	Yes	Yes	1	6	8
186	R:R:N295	R:R:R233	9.64	No	Yes	0	8	8
187	R:R:R233	R:R:Y421	3.09	Yes	Yes	1	8	8
188	R:R:N448	R:R:R233	3.62	Yes	Yes	1	6	8
189	L:L:E4	R:R:R233	4.65	Yes	Yes	1	0	8
190	R:R:F291	R:R:S236	9.25	Yes	No	0	5	7
191	R:R:F288	R:R:I237	3.77	Yes	No	0	7	7
192	R:R:F288	R:R:K240	7.44	Yes	No	0	7	7
193	R:R:A284	R:R:V243	3.39	No	No	0	6	5
194	R:R:L244	R:R:Y245	5.86	Yes	Yes	0	5	4
195	R:R:C281	R:R:L244	4.76	No	Yes	9	9	5
196	R:R:C351	R:R:L244	3.17	Yes	Yes	9	9	5
197	R:R:D353	R:R:L244	8.14	Yes	Yes	9	5	5
198	L:L:L8	R:R:Y245	3.52	No	Yes	0	0	4
199	L:L:K11	R:R:Y245	21.5	No	Yes	0	0	4
200	R:R:G277	R:R:Y278	2.9	No	No	0	4	4
201	R:R:G280	R:R:V283	3.68	No	No	0	4	4
202	R:R:C281	R:R:C351	7.28	No	Yes	9	9	9
203	R:R:N348	R:R:R282	3.62	No	No	3	7	8
204	R:R:R282	R:R:W352	25.99	No	Yes	3	8	8
205	R:R:F287	R:R:V283	5.24	No	No	0	3	4
206	R:R:T286	R:R:V340	3.17	No	No	0	7	5
207	R:R:F288	R:R:L289	4.87	Yes	No	0	7	7
208	R:R:F288	R:R:L292	6.09	Yes	Yes	0	7	6
209	R:R:L289	R:R:W339	6.83	No	Yes	3	7	8
210	R:R:I363	R:R:L289	7.14	No	No	3	7	7
211	R:R:F291	R:R:Y290	8.25	Yes	No	0	5	9
212	R:R:T294	R:R:Y290	7.49	No	No	4	8	9
213	R:R:P332	R:R:Y290	2.78	Yes	No	4	9	9
214	R:R:L292	R:R:Y296	4.69	Yes	Yes	1	6	7
215	L:L:E4	R:R:L292	2.65	Yes	Yes	1	0	6
216	R:R:A293	R:R:P332	3.74	No	Yes	4	6	9
217	R:R:A293	R:R:F335	2.77	No	Yes	4	6	5
218	R:R:T294	R:R:W329	7.28	No	No	4	8	9
219	R:R:P332	R:R:T294	5.25	Yes	No	4	9	8
220	R:R:I367	R:R:Y296	13.3	No	Yes	1	7	7
221	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
222	R:R:Y296	R:R:Y421	13.9	Yes	Yes	1	7	8
223	L:L:V2	R:R:Y296	6.31	Yes	Yes	1	0	7
224	R:R:F327	R:R:Y297	7.22	No	Yes	0	5	6
225	R:R:F335	R:R:Y297	4.13	Yes	Yes	4	5	6
226	R:R:P366	R:R:Y297	5.56	No	Yes	4	9	6
227	R:R:S370	R:R:Y297	3.82	No	Yes	0	7	6
228	R:R:V301	R:R:W298	7.36	No	Yes	0	8	9
229	R:R:G328	R:R:W298	7.04	No	Yes	0	9	9
230	R:R:W298	R:R:W329	16.87	Yes	No	4	9	9
231	R:R:I299	R:R:N374	4.25	No	No	0	9	9
232	R:R:L300	R:R:L304	4.15	Yes	No	0	8	5
233	R:R:L300	R:R:S370	4.5	Yes	No	0	8	7
234	R:R:L300	R:R:L373	6.92	Yes	No	0	8	7
235	R:R:L300	R:R:N374	4.12	Yes	No	0	8	9
236	R:R:F324	R:R:V301	5.24	No	No	0	7	8
237	R:R:E302	R:R:L416	5.3	Yes	No	0	9	9
238	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
239	R:R:L304	R:R:L377	2.77	No	No	0	5	7
240	R:R:L309	R:R:Y305	5.86	No	Yes	0	8	8
241	R:R:F315	R:R:Y305	5.16	Yes	Yes	6	6	8
242	R:R:E317	R:R:Y305	5.61	No	Yes	6	6	8
243	R:R:F324	R:R:Y305	3.09	No	Yes	0	7	8
244	R:R:F311	R:R:H307	10.18	Yes	Yes	7	6	8
245	R:R:H307	R:R:L377	9	Yes	No	0	8	7
246	R:R:H307	R:R:N380	7.65	Yes	No	7	8	8
247	R:R:H307	R:R:I381	2.65	Yes	No	0	8	9
248	R:R:F315	R:R:S308	3.96	Yes	No	0	6	7
249	R:R:F311	R:R:I310	6.28	Yes	No	7	6	8
250	R:R:I310	R:R:V384	3.07	No	No	7	8	8
251	R:R:F311	R:R:N380	7.25	Yes	No	7	6	8
252	R:R:F311	R:R:V384	3.93	Yes	No	7	6	8
253	R:R:F315	R:R:M312	6.22	Yes	No	6	6	5
254	R:R:M312	R:R:Y320	4.79	No	No	6	5	4
255	R:R:A313	R:R:F314	2.77	No	No	0	7	7
256	R:R:E317	R:R:F315	11.66	No	Yes	6	6	6
257	R:R:F315	R:R:Y320	20.63	Yes	No	6	6	4
258	R:R:K319	R:R:S316	6.12	No	No	0	6	7
259	R:R:F327	R:R:L331	4.87	No	No	0	5	4
260	R:R:F335	R:R:P332	7.22	Yes	Yes	4	5	9
261	R:R:F335	R:R:P366	8.67	Yes	No	4	5	9
262	R:R:S341	R:R:V338	3.23	No	No	0	5	5
263	R:R:I362	R:R:V338	4.61	No	No	0	8	5
264	R:R:V340	R:R:W339	3.68	No	Yes	0	5	8
265	R:R:R343	R:R:W339	10	Yes	Yes	3	8	8
266	R:R:W339	R:R:W352	3.75	Yes	Yes	3	8	8
267	R:R:I363	R:R:W339	12.92	No	Yes	3	7	8
268	R:R:S341	R:R:V342	3.23	No	No	0	5	5
269	R:R:K359	R:R:V342	3.04	Yes	No	0	3	5
270	R:R:I362	R:R:V342	4.61	No	No	0	8	5
271	R:R:A347	R:R:R343	5.53	Yes	Yes	3	7	8
272	R:R:R343	R:R:W352	17.99	Yes	Yes	3	8	8
273	R:R:R343	R:R:S356	10.54	Yes	No	3	8	4
274	R:R:L346	R:R:T345	5.9	No	No	0	3	3
275	R:R:A347	R:R:S356	3.42	Yes	No	3	7	4
276	R:R:A347	R:R:K359	3.21	Yes	Yes	3	7	3
277	R:R:N348	R:R:W352	3.39	No	Yes	3	7	8
278	R:R:C351	R:R:D353	7.78	Yes	Yes	9	9	5
279	R:R:D353	R:R:L354	2.71	Yes	No	0	5	5
280	L:L:L8	R:R:D353	4.07	No	Yes	0	0	5
281	L:L:Q16	R:R:L354	3.99	No	No	0	0	5
282	R:R:K360	R:R:S355	6.12	No	No	0	7	7
283	L:L:H9	R:R:S355	11.16	No	No	0	0	7
284	R:R:K359	R:R:S356	7.65	Yes	No	3	3	4
285	R:R:N358	R:R:W361	6.78	No	No	0	4	8
286	R:R:K360	R:R:W361	10.44	No	No	0	7	8
287	R:R:K360	R:R:Y429	13.14	No	Yes	0	7	6
288	R:R:Q364	R:R:W361	8.76	No	No	0	7	8
289	R:R:Q364	R:R:Y429	6.76	No	Yes	1	7	6
290	L:L:H5	R:R:Q364	11.13	Yes	No	1	0	7
291	R:R:P366	R:R:V365	3.53	No	No	0	9	5
292	L:L:V2	R:R:I367	4.61	Yes	No	1	0	7
293	R:R:L368	R:R:M425	7.07	No	Yes	0	4	6
294	R:R:I371	R:R:Y421	4.84	No	Yes	1	7	8
295	R:R:I371	R:R:M425	2.92	No	Yes	0	7	6
296	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
297	R:R:F417	R:R:N374	10.87	Yes	No	0	9	9
298	R:R:F375	R:R:I379	6.28	No	No	0	7	5
299	R:R:F375	R:R:V419	3.93	No	No	0	7	7
300	R:R:F375	R:R:I422	8.79	No	No	0	7	5
301	R:R:F378	R:R:V382	5.24	Yes	No	15	9	7
302	R:R:F378	R:R:T410	3.89	Yes	No	15	9	9
303	R:R:F378	R:R:L413	4.87	Yes	No	0	9	9
304	R:R:F378	R:R:F417	9.65	Yes	Yes	0	9	9
305	R:R:F378	R:R:V419	7.87	Yes	No	0	9	7
306	R:R:N380	R:R:R383	7.23	No	No	0	8	8
307	R:R:I381	R:R:L385	2.85	No	No	0	9	8
308	R:R:I381	R:R:L413	2.85	No	No	0	9	9
309	R:R:T410	R:R:V382	4.76	No	No	15	9	7
310	R:R:K388	R:R:V384	3.04	No	No	0	9	8
311	R:R:E391	R:R:T387	5.64	No	No	0	7	7
312	R:R:L389	R:R:Q402	7.99	No	No	0	8	6
313	R:R:K405	R:R:L389	2.82	No	No	0	8	8
314	R:R:L389	R:R:L406	2.77	No	No	0	8	8
315	R:R:E391	R:R:R390	5.82	No	No	0	7	6
316	R:R:Q401	R:R:T399	2.83	No	No	0	6	6
317	R:R:R400	R:R:Y403	9.26	No	No	0	8	7
318	R:R:Q401	R:R:R404	7.01	No	No	0	6	6
319	R:R:Q402	R:R:Y403	4.51	No	No	0	6	7
320	R:R:K405	R:R:S409	3.06	No	No	0	8	9
321	R:R:K408	R:R:V412	3.04	No	No	0	8	8
322	R:R:I458	R:R:V412	3.07	No	No	0	8	8
323	R:R:M414	R:R:P415	3.35	No	No	0	8	9
324	R:R:M414	R:R:V419	3.04	No	No	0	8	7
325	R:R:F454	R:R:P415	2.89	No	No	0	6	9
326	R:R:I458	R:R:P415	3.39	No	No	0	8	9
327	R:R:L416	R:R:V455	2.98	No	Yes	14	9	9
328	R:R:L416	R:R:Y459	17.58	No	No	14	9	8
329	R:R:G418	R:R:Y421	2.9	No	Yes	1	9	8
330	R:R:G418	R:R:Q451	3.29	No	Yes	1	9	9
331	R:R:H420	R:R:Y421	18.51	Yes	Yes	1	8	8
332	R:R:H420	R:R:Y443	4.36	Yes	Yes	1	8	4
333	R:R:F447	R:R:H420	15.84	No	Yes	1	5	8
334	R:R:H420	R:R:N448	5.1	Yes	Yes	1	8	6
335	R:R:H420	R:R:Q451	7.42	Yes	Yes	1	8	9
336	R:R:N448	R:R:Y421	13.96	Yes	Yes	1	6	8
337	R:R:Q451	R:R:Y421	6.76	Yes	Yes	1	9	8
338	R:R:I422	R:R:M425	2.92	No	Yes	0	5	6
339	R:R:F424	R:R:V423	9.18	Yes	No	1	7	6
340	R:R:V423	R:R:Y443	6.31	No	Yes	1	6	4
341	R:R:F424	R:R:T427	3.89	Yes	Yes	1	7	5
342	R:R:F424	R:R:Q440	12.88	Yes	Yes	1	7	6
343	R:R:F424	R:R:Y443	7.22	Yes	Yes	1	7	4
344	R:R:E444	R:R:F424	7	Yes	Yes	1	7	7
345	R:R:P428	R:R:T427	3.5	No	Yes	0	7	5
346	R:R:L436	R:R:T427	4.42	No	Yes	0	4	5
347	R:R:Q440	R:R:T427	7.09	Yes	Yes	1	6	5
348	L:L:A1	R:R:Y429	2.67	No	Yes	0	0	6
349	L:L:H5	R:R:Y429	3.27	Yes	Yes	1	0	6
350	L:L:Q6	R:R:Y429	13.53	Yes	Yes	1	0	6
351	L:L:H9	R:R:Y429	4.36	No	Yes	1	0	6
352	R:R:L436	R:R:T430	7.37	No	No	0	4	5
353	R:R:E431	R:R:S433	5.75	No	No	0	3	3
354	R:R:V432	R:R:W437	12.26	No	Yes	1	5	5
355	L:L:D10	R:R:V432	4.38	No	No	1	0	5
356	R:R:M441	R:R:W437	19.78	Yes	Yes	1	6	5
357	L:L:Q6	R:R:W437	5.48	Yes	Yes	1	0	5
358	L:L:D10	R:R:W437	16.75	No	Yes	1	0	5
359	R:R:E444	R:R:Q440	8.92	Yes	Yes	1	7	6
360	L:L:Q6	R:R:Q440	6.4	Yes	Yes	1	0	6
361	L:L:S3	R:R:M441	4.6	Yes	Yes	1	0	6
362	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
363	L:L:L7	R:R:M441	4.24	Yes	Yes	1	0	6
364	R:R:E444	R:R:Y443	3.37	Yes	Yes	1	7	4
365	R:R:F447	R:R:Y443	9.28	No	Yes	1	5	4
366	L:L:S3	R:R:E444	12.94	Yes	Yes	1	0	7
367	L:L:S3	R:R:M445	3.07	Yes	Yes	1	0	6
368	L:L:E4	R:R:M445	4.06	Yes	Yes	1	0	6
369	L:L:L7	R:R:M445	4.24	Yes	Yes	1	0	6
370	R:R:F450	R:R:L446	4.87	No	No	0	7	5
371	L:L:E4	R:R:N448	13.15	Yes	Yes	1	0	6
372	R:R:F450	R:R:S449	6.61	No	No	1	7	9
373	R:R:F453	R:R:I457	7.54	Yes	No	0	6	6
374	R:R:V455	R:R:Y459	3.79	Yes	No	14	9	8
375	R:R:I458	R:R:Y459	13.3	No	No	0	8	8
376	R:R:C460	R:R:F461	2.79	No	No	0	9	8
377	R:R:G464	R:R:N463	3.39	No	No	0	7	9
378	R:R:N463	R:R:V466	4.43	No	No	0	9	9
379	R:R:E469	R:R:K472	10.8	Yes	No	0	9	7
380	R:R:K472	R:R:R476	11.14	No	No	0	7	7
381	R:R:T478	R:R:W474	7.28	No	No	0	4	5
382	R:R:A480	R:R:W477	3.89	No	No	0	4	4
383	L:L:E4	L:L:V2	2.85	Yes	Yes	1	0	0
384	L:L:H5	L:L:V2	2.77	Yes	Yes	1	0	0
385	L:L:E4	L:L:S3	4.31	Yes	Yes	1	0	0
386	L:L:H5	L:L:H9	13.14	Yes	No	1	0	0
387	L:L:D10	L:L:Q6	7.83	No	Yes	1	0	0
388	L:L:D17	L:L:K13	11.06	No	No	0	0	0
389	L:L:Q16	L:L:R19	3.5	No	No	0	0	0
390	L:L:D17	L:L:R20	9.53	No	Yes	0	0	0
391	L:L:E22	L:L:L18	7.95	No	No	0	0	0
392	L:L:L23	L:L:L27	4.15	Yes	No	0	0	0
393	L:L:?29	L:L:K30	4.05	Yes	No	0	0	0
394	L:L:?29	L:L:T33	8.47	Yes	No	2	0	0
395	L:L:?29	L:L:?34	9.84	Yes	No	2	0	0
396	L:L:H32	L:L:T33	2.74	Yes	No	2	0	0
397	L:L:?34	L:L:T33	10.94	No	No	2	0	0
398	R:R:R147	R:R:V126	2.62	No	No	0	3	4
399	R:R:F184	R:R:V183	2.62	Yes	No	0	6	4
400	R:R:F335	R:R:V336	2.62	Yes	No	0	5	7
401	L:L:L31	R:R:H114	2.57	No	No	0	0	4
402	R:R:S449	R:R:Y195	2.54	No	Yes	1	9	7
403	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
404	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
405	R:R:F212	R:R:I470	2.51	Yes	No	0	7	5
406	R:R:F417	R:R:L306	2.44	Yes	No	0	9	9
407	L:L:I15	R:R:Y245	2.42	No	Yes	0	0	4
408	R:R:D185	R:R:R181	2.38	No	No	0	2	3
409	R:R:L41	R:R:Y134	2.34	No	Yes	0	8	5
410	R:R:Q57	R:R:R58	2.34	No	No	0	8	7
411	R:R:D133	R:R:Y134	2.3	No	Yes	0	2	5
412	R:R:F287	R:R:F291	2.14	No	Yes	0	3	5
413	R:R:G277	R:R:G350	2.11	No	No	0	4	5
414	R:R:G105	R:R:P107	2.03	No	No	0	5	3
415	R:R:G330	R:R:P332	2.03	No	Yes	0	7	9
416	R:R:C108	R:R:G152	1.96	No	No	0	9	9
417	R:R:A276	R:R:G277	1.95	No	No	0	4	4
418	R:R:A279	R:R:G280	1.95	No	No	0	4	4
419	R:R:A333	R:R:G330	1.95	No	No	0	5	7
420	R:R:A122	R:R:P123	1.87	No	No	0	1	7
421	R:R:G121	R:R:V127	1.84	No	No	0	7	7
422	R:R:G194	R:R:V193	1.84	No	No	0	9	6
423	R:R:A276	R:R:C351	1.81	No	Yes	0	4	9
424	L:L:G12	L:L:K11	1.74	No	No	0	0	0
425	R:R:C351	R:R:V285	1.71	Yes	No	0	9	6
426	R:R:G357	R:R:N358	1.7	No	No	0	6	4
427	R:R:A347	R:R:T349	1.68	Yes	No	0	7	5
428	R:R:E125	R:R:G121	1.64	No	No	0	5	7
429	R:R:C462	R:R:I457	1.64	No	No	0	6	6
430	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
431	R:R:A210	R:R:M224	1.61	No	No	0	4	5
432	R:R:V235	R:R:V239	1.6	No	No	0	4	5
433	R:R:V239	R:R:V243	1.6	No	No	0	5	5
434	R:R:G159	R:R:H160	1.59	No	No	0	3	4
435	R:R:A386	R:R:L406	1.58	No	No	0	6	8
436	R:R:M32	R:R:V31	1.52	Yes	No	0	6	6
437	R:R:G152	R:R:R106	1.5	No	No	0	9	1
438	R:R:L385	R:R:S409	1.5	No	No	0	8	9
439	R:R:L479	R:R:S475	1.5	No	No	0	4	4
440	R:R:L199	R:R:V235	1.49	No	No	0	7	4
441	R:R:L331	R:R:V334	1.49	No	No	0	4	4
442	R:R:L436	R:R:V439	1.49	No	No	0	4	5
443	R:R:D149	R:R:S153	1.47	No	No	0	5	4
444	R:R:L156	R:R:T163	1.47	No	No	0	4	5
445	R:R:P107	R:R:R106	1.44	No	No	0	3	1
446	L:L:S14	R:R:E180	1.44	No	Yes	0	0	3
447	R:R:E36	R:R:T33	1.41	No	No	0	6	7
448	R:R:K359	R:R:L346	1.41	Yes	No	0	3	3
449	R:R:L411	R:R:M414	1.41	No	No	0	8	8
450	R:R:A46	R:R:R43	1.38	No	No	0	5	4
451	R:R:L52	R:R:L56	1.38	No	No	5	4	7
452	R:R:L109	R:R:L56	1.38	Yes	No	5	5	7
453	R:R:A344	R:R:W352	1.3	No	Yes	0	4	8
454	L:L:R21	R:R:T178	1.29	No	No	0	0	3
455	L:L:?29	L:L:E25	1.27	Yes	No	0	0	0
456	R:R:F173	R:R:L174	1.22	No	No	0	3	3
457	L:L:R21	R:R:N176	1.21	No	No	0	0	3
458	R:R:M224	R:R:Y221	1.2	No	No	0	5	7
459	R:R:D149	R:R:R150	1.19	No	No	0	5	1
460	R:R:E36	R:R:F39	1.17	No	No	0	6	7
461	R:R:Q402	R:R:R390	1.17	No	No	0	6	6
462	R:R:E54	R:R:R58	1.16	No	No	0	6	7
463	R:R:E180	R:R:R179	1.16	Yes	No	0	3	3
464	L:L:E22	L:L:R19	1.16	No	No	0	0	0
465	R:R:E111	R:R:W112	1.09	No	Yes	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M32	6.376	5	8	6
2	R:R:Q37	3.375	4	0	7
3	R:R:L109	2.636	5	5	5
4	R:R:P110	5.5225	4	5	6
5	R:R:W112	7.985	4	0	7
6	R:R:D113	9.01	4	2	9
7	R:R:I115	6.022	5	2	5
8	R:R:L116	7.22833	6	2	5
9	R:R:W118	10.1886	7	2	9
10	R:R:V129	4.0425	4	2	5
11	R:R:Y134	5.60333	6	2	5
12	R:R:I135	7.842	5	2	7
13	R:R:D137	6.9825	4	8	5
14	R:R:F138	9.295	4	2	4
15	R:R:V157	5.15	4	0	4
16	R:R:W164	11.605	4	2	5
17	R:R:Y167	5.86857	7	2	5
18	R:R:E180	3.1275	4	0	3
19	R:R:F184	6.1675	4	0	6
20	R:R:L187	4.4425	4	1	5
21	R:R:Y191	5.066	5	1	7
22	R:R:Y195	4.835	6	1	7
23	R:R:L202	3.93	4	0	9
24	R:R:F212	5.64667	6	13	7
25	R:R:L226	6.7925	4	0	9
26	R:R:F227	4.00333	6	0	9
27	R:R:F230	7.78	6	0	8
28	R:R:M231	3.472	5	12	8
29	R:R:R233	5.54	6	1	8
30	R:R:L244	5.4825	4	9	5
31	R:R:Y245	8.325	4	0	4
32	R:R:F288	5.5425	4	0	7
33	R:R:F291	7.65	4	0	5
34	R:R:L292	4.875	4	1	6
35	R:R:Y296	8.608	5	1	7
36	R:R:Y297	5.1825	4	4	6
37	R:R:W298	11.122	5	4	9
38	R:R:L300	4.9225	4	0	8
39	R:R:E302	8.8	4	0	9
40	R:R:Y305	5.73667	6	6	8
41	R:R:H307	7.37	4	7	8
42	R:R:F311	6.91	4	7	6
43	R:R:F315	9.526	5	6	6
44	R:R:P332	4.204	5	4	9
45	R:R:F335	5.082	5	4	5
46	R:R:W339	7.436	5	3	8
47	R:R:R343	11.015	4	3	8
48	R:R:A347	3.46	4	3	7
49	R:R:C351	4.35	5	9	9
50	R:R:W352	10.484	5	3	8
51	R:R:D353	5.675	4	9	5
52	R:R:K359	3.8275	4	3	3
53	R:R:F378	6.304	5	15	9
54	R:R:F417	7.245	4	0	9
55	R:R:H420	10.246	5	1	8
56	R:R:Y421	9.13714	7	1	8
57	R:R:F424	8.034	5	1	7
58	R:R:M425	3.9875	4	0	6
59	R:R:T427	4.725	4	1	5
60	R:R:Y429	7.28833	6	1	6
61	R:R:W437	12.056	5	1	5
62	R:R:Q440	8.8225	4	1	6
63	R:R:M441	8.214	5	1	6
64	R:R:Y443	6.108	5	1	4
65	R:R:E444	8.0575	4	1	7
66	R:R:M445	4.038	5	1	6
67	R:R:N448	8.9575	4	1	6
68	R:R:Q451	5.8325	4	1	9
69	R:R:F453	5.835	4	0	6
70	R:R:V455	3.6575	4	14	9
71	R:R:E469	9.1875	4	13	9
72	L:L:V2	4.135	4	1	0
73	L:L:S3	6.23	4	1	0
74	L:L:E4	5.27833	6	1	0
75	L:L:H5	7.5775	4	1	0
76	L:L:Q6	8.008	5	1	0
77	L:L:L7	4.375	4	1	0
78	L:L:R20	11.485	4	8	0
79	L:L:L23	3.12	4	10	0
80	L:L:?29	5.9075	4	2	0
81	L:L:H32	4.835	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E36	R:R:M32	90.6899	5.41	No	Yes	0	6	6
2	R:R:M32	R:R:Q37	77.0377	5.44	Yes	Yes	0	6	7
3	R:R:E36	R:R:T33	93.4322	1.41	No	No	0	6	7
4	L:L:Q16	R:R:T33	94.52	4.25	No	No	0	0	7
5	L:L:L23	R:R:Q37	18.2481	2.66	Yes	Yes	0	0	7
6	R:R:I135	R:R:Q37	57.789	2.74	Yes	Yes	0	7	7
7	R:R:I135	R:R:P132	47.7502	8.47	Yes	No	2	7	9
8	R:R:L116	R:R:P132	47.6181	8.21	Yes	No	2	5	9
9	R:R:L116	R:R:W118	20.9168	14.81	Yes	Yes	2	5	9
10	R:R:R146	R:R:W118	12.649	26.99	No	Yes	0	8	9
11	R:R:R146	R:R:W154	10.5976	27.99	No	No	0	8	9
12	R:R:C108	R:R:W154	10.0459	16.98	No	No	0	9	9
13	L:L:L27	R:R:I115	15.8961	4.28	No	Yes	0	0	5
14	L:L:L23	L:L:L27	16.4856	4.15	Yes	No	0	0	0
15	R:R:L116	R:R:Y167	13.4915	3.52	Yes	Yes	2	5	5
16	R:R:I115	R:R:Y167	13.1864	6.04	Yes	Yes	2	5	5
17	R:R:L116	R:R:V129	12.2437	2.98	Yes	Yes	2	5	5
18	R:R:P119	R:R:V127	13.8702	3.53	No	No	0	6	7
19	R:R:E125	R:R:G121	11.1376	1.64	No	No	0	5	7
20	R:R:G121	R:R:V127	12.5241	1.84	No	No	0	7	7
21	R:R:N166	R:R:W164	12.243	3.39	No	Yes	2	7	5
22	L:L:H32	R:R:N166	13.5904	5.1	Yes	No	2	0	7
23	L:L:H32	R:R:Y167	23.0378	8.71	Yes	Yes	2	0	5
24	L:L:K11	R:R:F184	100	11.17	No	Yes	0	0	6
25	L:L:K11	R:R:Y245	99.7918	21.5	No	Yes	0	0	4
26	R:R:L244	R:R:Y245	50.89	5.86	Yes	Yes	0	5	4
27	R:R:D353	R:R:L244	48.5765	8.14	Yes	Yes	9	5	5
28	R:R:D353	R:R:L354	97.2167	2.71	Yes	No	0	5	5
29	L:L:Q16	R:R:L354	96.68	3.99	No	No	0	0	5
30	L:L:L8	R:R:Y245	48.6903	3.52	No	Yes	0	0	4
31	L:L:L8	R:R:D353	48.4808	4.07	No	Yes	0	0	5
32	L:L:L7	R:R:F184	93.1784	4.87	Yes	Yes	0	0	6
33	L:L:L7	R:R:M445	90.9534	4.24	Yes	Yes	1	0	6
34	R:R:M445	R:R:Y191	10.7772	5.99	Yes	Yes	1	6	7
35	L:L:E4	R:R:M445	81.3843	4.06	Yes	Yes	1	0	6
36	L:L:E4	R:R:R233	56.8736	4.65	Yes	Yes	1	0	8
37	R:R:N295	R:R:R233	56.7298	9.64	No	Yes	0	8	8
38	R:R:F230	R:R:N295	47.3963	18.12	Yes	No	0	8	8
39	R:R:F230	R:R:L202	13.1129	3.65	Yes	Yes	0	8	9
40	R:R:F230	R:R:L226	25.2856	6.09	Yes	Yes	0	8	9
41	R:R:F227	R:R:L226	11.2769	3.65	Yes	Yes	0	9	9
42	R:R:F230	R:R:V455	12.3692	3.93	Yes	Yes	0	8	9
43	R:R:A205	R:R:F227	19.9227	2.77	No	Yes	0	9	9
44	R:R:A205	R:R:C460	18.9377	3.61	No	No	0	9	9
45	R:R:C460	R:R:I208	15.9638	4.91	No	No	0	9	8
46	R:R:F212	R:R:I208	13.9931	2.51	Yes	No	0	7	8
47	R:R:N295	R:R:S229	12.9177	7.45	No	No	0	8	9
48	R:R:S229	R:R:W298	12.5351	7.41	No	Yes	0	9	9
49	R:R:I299	R:R:L226	12.9099	2.85	No	Yes	0	9	9
50	L:L:E4	R:R:L292	14.1304	2.65	Yes	Yes	1	0	6
51	R:R:F288	R:R:L292	12.9658	6.09	Yes	Yes	0	7	6
52	R:R:F288	R:R:L289	18.8102	4.87	Yes	No	0	7	7
53	R:R:L289	R:R:W339	17.5304	6.83	No	Yes	3	7	8
54	R:R:I371	R:R:Y421	13.1942	4.84	No	Yes	1	7	8
55	R:R:I371	R:R:Y296	13.202	4.84	No	Yes	1	7	7
56	R:R:I299	R:R:N374	12.5917	4.25	No	No	0	9	9
57	R:R:F378	R:R:L413	18.1127	4.87	Yes	No	0	9	9
58	R:R:I381	R:R:L413	16.8415	2.85	No	No	0	9	9
59	R:R:I371	R:R:M425	25.363	2.92	No	Yes	0	7	6
60	R:R:I422	R:R:M425	22.3182	2.92	No	Yes	0	5	6
61	R:R:F375	R:R:I422	21.3085	8.79	No	No	0	7	5
62	R:R:F375	R:R:V419	19.5818	3.93	No	No	0	7	7
63	R:R:F378	R:R:V419	16.9631	7.87	Yes	No	0	9	7
64	R:R:R343	R:R:W339	13.0374	10	Yes	Yes	3	8	8
65	R:R:I381	R:R:L385	15.5201	2.85	No	No	0	9	8
66	R:R:L385	R:R:S409	14.2339	1.5	No	No	0	8	9
67	R:R:K405	R:R:S409	12.9463	3.06	No	No	0	8	9
68	R:R:K405	R:R:L389	11.6575	2.82	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E36	R:R:M32	5.41	0	No	Yes	6	6	2	1
R:R:M32	R:R:Q37	5.44	8	Yes	Yes	6	7	1	1
R:R:M32	R:R:Y136	9.58	8	Yes	No	6	4	1	1
L:L:R20	R:R:M32	9.93	8	Yes	Yes	0	6	0	1
R:R:E35	R:R:T33	4.23	0	No	No	5	7	2	1
L:L:Q16	R:R:T33	4.25	0	No	No	0	7	0	1
R:R:I38	R:R:K34	2.91	10	No	No	7	4	1	1
L:L:L23	R:R:K34	2.82	10	Yes	No	0	4	0	1
R:R:L40	R:R:Q37	2.66	0	No	Yes	5	7	2	1
R:R:I135	R:R:Q37	2.74	2	Yes	Yes	7	7	1	1
L:L:L23	R:R:Q37	2.66	10	Yes	Yes	0	7	0	1
L:L:L23	R:R:I38	2.85	10	Yes	No	0	7	0	1
R:R:D113	R:R:I115	9.8	2	Yes	Yes	9	5	2	1
R:R:D113	R:R:L116	8.14	2	Yes	Yes	9	5	2	2
R:R:D113	R:R:W118	10.05	2	Yes	Yes	9	9	2	2
R:R:D113	R:R:Y167	8.05	2	Yes	Yes	9	5	2	1
R:R:I115	R:R:L116	5.71	2	Yes	Yes	5	5	1	2
R:R:I115	R:R:Y167	6.04	2	Yes	Yes	5	5	1	1
L:L:L27	R:R:I115	4.28	0	No	Yes	0	5	0	1
L:L:L31	R:R:I115	4.28	0	No	Yes	0	5	0	1
R:R:L116	R:R:W118	14.81	2	Yes	Yes	5	9	2	2
R:R:L116	R:R:P132	8.21	2	Yes	No	5	9	2	2
R:R:L116	R:R:Y167	3.52	2	Yes	Yes	5	5	2	1
R:R:A144	R:R:W118	3.89	2	No	Yes	7	9	2	2
R:R:W118	R:R:Y167	6.75	2	Yes	Yes	9	5	2	1
R:R:P132	R:R:Y134	12.52	2	No	Yes	9	5	2	2
R:R:I135	R:R:P132	8.47	2	Yes	No	7	9	1	2
R:R:I135	R:R:Y134	3.63	2	Yes	Yes	7	5	1	2
R:R:F138	R:R:I135	20.09	2	Yes	Yes	4	7	1	1
L:L:L24	R:R:I135	4.28	0	No	Yes	0	7	0	1
R:R:D137	R:R:Y136	8.05	8	Yes	No	5	4	1	1
L:L:R20	R:R:Y136	13.38	8	Yes	No	0	4	0	1
R:R:D137	R:R:L174	2.71	8	Yes	No	5	3	1	2
L:L:R20	R:R:D137	13.1	8	Yes	Yes	0	5	0	1
L:L:L24	R:R:D137	4.07	0	No	Yes	0	5	0	1
R:R:C170	R:R:F138	6.98	0	No	Yes	9	4	2	1
R:R:F138	R:R:V171	5.24	2	Yes	No	4	3	1	1
L:L:L28	R:R:F138	4.87	2	No	Yes	0	4	0	1
R:R:A144	R:R:Y167	2.67	2	No	Yes	7	5	2	1
R:R:N166	R:R:W164	3.39	2	No	Yes	7	5	1	2
R:R:A165	R:R:Y167	5.34	0	No	Yes	7	5	2	1
R:R:N166	R:R:S168	7.45	2	No	No	7	6	1	1
L:L:H32	R:R:N166	5.1	2	Yes	No	0	7	0	1
L:L:H32	R:R:Y167	8.71	2	Yes	Yes	0	5	0	1
L:L:H32	R:R:S168	2.79	2	Yes	No	0	6	0	1
R:R:L174	R:R:V171	2.98	0	No	No	3	3	2	1
L:L:L28	R:R:V171	5.96	2	No	No	0	3	0	1
R:R:E180	R:R:T178	7.06	0	Yes	No	3	3	1	1
R:R:E180	R:R:V183	2.85	0	Yes	No	3	4	1	2
R:R:F184	R:R:W437	6.01	0	Yes	Yes	6	5	1	1
L:L:L7	R:R:F184	4.87	1	Yes	Yes	0	6	0	1
L:L:K11	R:R:F184	11.17	0	No	Yes	0	6	0	1
R:R:L187	R:R:M441	5.65	1	Yes	Yes	5	6	1	1
R:R:H442	R:R:L187	5.14	0	No	Yes	5	5	2	1
R:R:L187	R:R:M445	2.83	1	Yes	Yes	5	6	1	1
L:L:L7	R:R:L187	4.15	1	Yes	Yes	0	5	0	1
R:R:Y191	R:R:Y195	5.96	1	Yes	Yes	7	7	2	2
R:R:M445	R:R:Y191	5.99	1	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	6.17	1	Yes	Yes	8	7	1	2
R:R:L292	R:R:R233	6.07	1	Yes	Yes	6	8	1	1
R:R:N295	R:R:R233	9.64	0	No	Yes	8	8	2	1
R:R:R233	R:R:Y421	3.09	1	Yes	Yes	8	8	1	2
R:R:N448	R:R:R233	3.62	1	Yes	Yes	6	8	1	1
L:L:E4	R:R:R233	4.65	1	Yes	Yes	0	8	0	1
R:R:L244	R:R:Y245	5.86	9	Yes	Yes	5	4	2	1
R:R:C351	R:R:L244	3.17	9	Yes	Yes	9	5	2	2
R:R:D353	R:R:L244	8.14	9	Yes	Yes	5	5	1	2
L:L:L8	R:R:Y245	3.52	0	No	Yes	0	4	0	1
L:L:K11	R:R:Y245	21.5	0	No	Yes	0	4	0	1
R:R:F288	R:R:L292	6.09	0	Yes	Yes	7	6	2	1
R:R:L292	R:R:Y296	4.69	1	Yes	Yes	6	7	1	1
L:L:E4	R:R:L292	2.65	1	Yes	Yes	0	6	0	1
R:R:I367	R:R:Y296	13.3	1	No	Yes	7	7	1	1
R:R:I371	R:R:Y296	4.84	1	No	Yes	7	7	2	1
R:R:Y296	R:R:Y421	13.9	1	Yes	Yes	7	8	1	2
L:L:V2	R:R:Y296	6.31	1	Yes	Yes	0	7	0	1
R:R:C351	R:R:D353	7.78	9	Yes	Yes	9	5	2	1
R:R:D353	R:R:L354	2.71	9	Yes	No	5	5	1	1
L:L:L8	R:R:D353	4.07	0	No	Yes	0	5	0	1
L:L:Q16	R:R:L354	3.99	0	No	No	0	5	0	1
R:R:K360	R:R:S355	6.12	0	No	No	7	7	2	1
L:L:H9	R:R:S355	11.16	1	No	No	0	7	0	1
R:R:K360	R:R:W361	10.44	0	No	No	7	8	2	2
R:R:K360	R:R:Y429	13.14	0	No	Yes	7	6	2	1
R:R:Q364	R:R:W361	8.76	1	No	No	7	8	1	2
R:R:Q364	R:R:Y429	6.76	1	No	Yes	7	6	1	1
L:L:H5	R:R:Q364	11.13	1	Yes	No	0	7	0	1
L:L:V2	R:R:I367	4.61	1	Yes	No	0	7	0	1
R:R:I371	R:R:Y421	4.84	1	No	Yes	7	8	2	2
R:R:H420	R:R:Y421	18.51	1	Yes	Yes	8	8	2	2
R:R:H420	R:R:Y443	4.36	1	Yes	Yes	8	4	2	2
R:R:H420	R:R:N448	5.1	1	Yes	Yes	8	6	2	1
R:R:N448	R:R:Y421	13.96	1	Yes	Yes	6	8	1	2
R:R:F424	R:R:T427	3.89	1	Yes	Yes	7	5	2	2
R:R:F424	R:R:Q440	12.88	1	Yes	Yes	7	6	2	1
R:R:F424	R:R:Y443	7.22	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	7	1	Yes	Yes	7	7	1	2
R:R:Q440	R:R:T427	7.09	1	Yes	Yes	6	5	1	2
L:L:A1	R:R:Y429	2.67	0	No	Yes	0	6	0	1
L:L:H5	R:R:Y429	3.27	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:Y429	13.53	1	Yes	Yes	0	6	0	1
L:L:H9	R:R:Y429	4.36	1	No	Yes	0	6	0	1
R:R:V432	R:R:W437	12.26	1	No	Yes	5	5	1	1
L:L:D10	R:R:V432	4.38	1	No	No	0	5	0	1
R:R:M441	R:R:W437	19.78	1	Yes	Yes	6	5	1	1
L:L:Q6	R:R:W437	5.48	1	Yes	Yes	0	5	0	1
L:L:D10	R:R:W437	16.75	1	No	Yes	0	5	0	1
R:R:E444	R:R:Q440	8.92	1	Yes	Yes	7	6	1	1
L:L:Q6	R:R:Q440	6.4	1	Yes	Yes	0	6	0	1
L:L:S3	R:R:M441	4.6	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:M441	4.24	1	Yes	Yes	0	6	0	1
R:R:E444	R:R:Y443	3.37	1	Yes	Yes	7	4	1	2
L:L:S3	R:R:E444	12.94	1	Yes	Yes	0	7	0	1
L:L:S3	R:R:M445	3.07	1	Yes	Yes	0	6	0	1
L:L:E4	R:R:M445	4.06	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:M445	4.24	1	Yes	Yes	0	6	0	1
L:L:E4	R:R:N448	13.15	1	Yes	Yes	0	6	0	1
R:R:F184	R:R:V183	2.62	0	Yes	No	6	4	1	2
L:L:L31	R:R:H114	2.57	0	No	No	0	4	0	1
L:L:I15	R:R:Y245	2.42	0	No	Yes	0	4	0	1
R:R:M32	R:R:V31	1.52	8	Yes	No	6	6	1	2
L:L:S14	R:R:E180	1.44	0	No	Yes	0	3	0	1
R:R:E36	R:R:T33	1.41	0	No	No	6	7	2	1
L:L:R21	R:R:T178	1.29	0	No	No	0	3	0	1
L:L:R21	R:R:N176	1.21	0	No	No	0	3	0	1
R:R:E180	R:R:R179	1.16	0	Yes	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7Y35_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	379
Number of Links	465
Number of Hubs	81
Number of Links mediated by Hubs	283
Number of Communities	15
Number of Nodes involved in Communities	124
Number of Links involved in Communities	180

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	217774
Length Of Smallest Path	3
Average Path Length	22.1956
Length of Longest Path	45
Minimum Path Strength	1.25
Average Path Strength	6.30839
Maximum Path Strength	27.49
Minimum Path Correlation	0.7
Average Path Correlation	0.962256
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	59.5025
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.0754
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • response to hypoxia • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?29
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?34
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>7Y35_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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