psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M32	R:R:Y278	3.59	Yes	Yes	3	6	4
2	R:R:G350	R:R:M32	3.49	No	Yes	3	5	6
3	R:R:C351	R:R:M32	4.86	No	Yes	3	9	6
4	L:L:Q16	R:R:M32	14.95	No	Yes	0	0	6
5	R:R:Q37	R:R:T33	2.83	Yes	No	0	7	7
6	L:L:Q16	R:R:T33	4.25	No	No	0	0	7
7	L:L:A18	R:R:K34	3.21	No	No	0	0	4
8	L:L:R19	R:R:K34	7.43	Yes	No	0	0	4
9	L:L:R19	R:R:Q37	4.67	Yes	Yes	0	0	7
10	L:L:R20	R:R:Q37	9.35	No	Yes	0	0	7
11	R:R:H42	R:R:I38	2.65	No	No	0	4	7
12	L:L:R19	R:R:I38	8.77	Yes	No	0	0	7
13	R:R:L41	R:R:W112	3.42	No	Yes	0	8	7
14	R:R:A44	R:R:W112	3.89	No	Yes	0	7	7
15	R:R:Q45	R:R:W112	14.24	No	Yes	6	7	7
16	R:R:H114	R:R:Q45	4.95	No	No	6	4	7
17	R:R:C48	R:R:W112	9.14	No	Yes	0	8	7
18	R:R:C117	R:R:C48	7.28	No	No	0	9	8
19	R:R:E49	R:R:L52	2.65	No	No	0	6	4
20	R:R:L52	R:R:P110	3.28	No	No	0	4	6
21	R:R:P107	R:R:R106	2.88	No	No	0	3	1
22	R:R:L120	R:R:P107	6.57	No	No	0	4	3
23	R:R:C108	R:R:G121	3.92	No	No	0	9	7
24	R:R:C108	R:R:C148	7.28	No	No	1	9	9
25	R:R:L109	R:R:P110	3.28	No	No	0	5	6
26	R:R:E111	R:R:W154	11.99	No	Yes	0	7	9
27	R:R:H114	R:R:W112	3.17	No	Yes	6	4	7
28	R:R:D113	R:R:W118	12.28	No	Yes	1	9	9
29	R:R:D113	R:R:R146	5.96	No	Yes	1	9	8
30	L:L:F23	R:R:I115	3.77	No	No	0	0	5
31	R:R:L116	R:R:W118	7.97	No	Yes	1	5	9
32	R:R:L116	R:R:V129	4.47	No	Yes	1	5	5
33	R:R:V129	R:R:W118	4.9	Yes	Yes	1	5	9
34	R:R:R146	R:R:W118	17.99	Yes	Yes	1	8	9
35	R:R:W118	R:R:W154	8.43	Yes	Yes	1	9	9
36	R:R:A122	R:R:E125	6.03	No	No	0	1	5
37	R:R:P123	R:R:R150	2.88	No	No	0	7	1
38	R:R:V126	R:R:Y145	3.79	No	No	0	4	4
39	R:R:R147	R:R:V126	7.85	No	No	0	3	4
40	R:R:A128	R:R:Y145	2.67	No	No	0	5	4
41	R:R:P130	R:R:V129	3.53	No	Yes	0	5	5
42	R:R:H143	R:R:P130	9.15	No	No	0	3	5
43	R:R:C131	R:R:C170	7.28	No	No	0	9	9
44	R:R:P132	R:R:Y134	4.17	No	No	0	9	5
45	R:R:I135	R:R:P132	3.39	No	No	0	7	9
46	R:R:D133	R:R:H140	6.3	No	No	0	2	3
47	R:R:F138	R:R:I135	13.82	No	No	0	4	7
48	L:L:R20	R:R:I135	10.02	No	No	0	0	7
49	R:R:D137	R:R:Y136	3.45	No	No	0	5	4
50	L:L:D17	R:R:D137	6.65	No	No	0	0	5
51	L:L:L24	R:R:F138	9.74	No	No	0	0	4
52	R:R:K141	R:R:N139	4.2	No	No	0	3	4
53	R:R:K172	R:R:N139	5.6	No	No	0	3	4
54	R:R:F173	R:R:N139	3.62	No	No	0	3	4
55	R:R:E169	R:R:G142	4.91	No	No	0	5	5
56	R:R:R146	R:R:W154	7	Yes	Yes	1	8	9
57	R:R:R146	R:R:T163	6.47	Yes	No	0	8	5
58	R:R:A165	R:R:R146	4.15	No	Yes	0	7	8
59	R:R:E155	R:R:R147	12.79	No	No	0	4	3
60	R:R:D149	R:R:N151	5.39	Yes	No	0	5	5
61	R:R:N166	R:R:S168	7.45	No	No	0	7	6
62	L:L:H25	R:R:Y167	9.8	No	No	0	0	5
63	R:R:L174	R:R:V171	4.47	No	No	0	3	3
64	R:R:E177	R:R:L174	2.65	Yes	No	7	1	3
65	L:L:R21	R:R:L174	7.29	No	No	7	0	3
66	R:R:E180	R:R:N176	6.57	No	No	0	3	3
67	L:L:W14	R:R:E177	4.36	No	Yes	0	0	1
68	L:L:D17	R:R:E177	6.5	No	Yes	0	0	1
69	L:L:R21	R:R:E177	3.49	No	Yes	7	0	1
70	R:R:R179	R:R:T178	5.17	No	No	0	3	3
71	L:L:R21	R:R:T178	3.88	No	No	0	0	3
72	R:R:E180	R:R:S433	8.62	No	No	0	3	3
73	L:L:W14	R:R:R181	6	No	No	0	0	3
74	R:R:E182	R:R:V183	2.85	No	No	0	2	4
75	R:R:Q438	R:R:V183	2.87	No	No	0	4	4
76	R:R:A188	R:R:F184	2.77	No	No	0	5	6
77	L:L:L7	R:R:F184	3.65	No	No	0	0	6
78	L:L:R11	R:R:F184	14.97	Yes	No	0	0	6
79	R:R:L187	R:R:M441	2.83	No	Yes	0	5	6
80	R:R:H442	R:R:L187	14.14	No	No	0	5	5
81	R:R:I190	R:R:M445	2.92	No	No	0	6	6
82	R:R:I190	R:R:L446	2.85	No	No	0	6	5
83	R:R:D241	R:R:Y191	11.49	No	No	0	8	7
84	L:L:R11	R:R:Y191	3.09	Yes	No	0	0	7
85	R:R:G194	R:R:S449	3.71	No	No	9	9	9
86	R:R:F450	R:R:G194	3.01	No	No	9	7	9
87	R:R:R233	R:R:Y195	9.26	Yes	No	2	8	7
88	R:R:I237	R:R:Y195	9.67	No	No	2	7	7
89	L:L:E4	R:R:Y195	7.86	Yes	No	2	0	7
90	R:R:F453	R:R:V197	5.24	Yes	No	0	6	5
91	R:R:G452	R:R:S198	3.71	No	No	0	9	9
92	R:R:F453	R:R:S201	7.93	Yes	No	0	6	8
93	R:R:F227	R:R:L202	6.09	Yes	No	0	9	9
94	R:R:F230	R:R:L202	3.65	Yes	No	0	8	9
95	R:R:A456	R:R:L202	3.15	No	No	0	8	9
96	R:R:I208	R:R:V204	3.07	No	No	0	8	5
97	R:R:A205	R:R:F227	2.77	No	Yes	0	9	9
98	R:R:A205	R:R:C460	3.61	No	No	0	9	9
99	R:R:F227	R:R:V206	3.93	Yes	No	0	9	5
100	R:R:L209	R:R:N220	2.75	No	No	0	7	9
101	R:R:L209	R:R:M224	4.24	No	No	0	7	5
102	R:R:F212	R:R:Y211	5.16	Yes	No	0	7	2
103	R:R:F212	R:R:L215	7.31	Yes	No	0	7	9
104	R:R:R213	R:R:R214	3.2	No	No	0	8	7
105	R:R:E469	R:R:R214	10.47	No	No	0	9	7
106	R:R:E465	R:R:L215	5.3	No	No	0	9	9
107	R:R:E317	R:R:T218	2.82	No	No	0	6	7
108	R:R:N220	R:R:R219	10.85	No	No	0	9	9
109	R:R:E465	R:R:R219	5.82	No	No	0	9	9
110	R:R:E302	R:R:I222	4.1	Yes	No	0	9	9
111	R:R:I222	R:R:Y305	8.46	No	No	0	9	8
112	R:R:H225	R:R:W298	12.7	No	Yes	0	8	9
113	R:R:F227	R:R:L226	4.87	Yes	No	0	9	9
114	R:R:F230	R:R:L226	8.53	Yes	No	0	8	9
115	R:R:E302	R:R:L226	15.9	Yes	No	0	9	9
116	R:R:S229	R:R:T294	3.2	No	No	0	9	8
117	R:R:N295	R:R:S229	5.96	No	No	0	8	9
118	R:R:F230	R:R:N295	8.46	Yes	No	0	8	8
119	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
120	R:R:F291	R:R:L232	17.05	No	No	0	5	8
121	R:R:L292	R:R:R233	4.86	No	Yes	2	6	8
122	R:R:N295	R:R:R233	7.23	No	Yes	0	8	8
123	R:R:N448	R:R:R233	3.62	No	Yes	0	6	8
124	L:L:E4	R:R:R233	11.63	Yes	Yes	2	0	8
125	R:R:F291	R:R:S236	7.93	No	No	0	5	7
126	R:R:D241	R:R:I237	4.2	No	No	0	8	7
127	L:L:E4	R:R:I237	4.1	Yes	No	2	0	7
128	R:R:K240	R:R:V243	3.04	No	No	0	7	5
129	R:R:K240	R:R:L244	12.69	No	No	0	7	5
130	R:R:D353	R:R:K240	4.15	Yes	No	0	5	7
131	R:R:A284	R:R:V243	3.39	No	No	0	6	5
132	L:L:R11	R:R:L244	13.36	Yes	No	0	0	5
133	R:R:G350	R:R:Y278	4.35	No	Yes	3	5	4
134	R:R:C281	R:R:C351	7.28	No	No	3	9	9
135	R:R:C281	R:R:D353	4.67	No	Yes	3	9	5
136	R:R:N348	R:R:R282	6.03	No	No	0	7	8
137	R:R:D353	R:R:V285	2.92	Yes	No	0	5	6
138	R:R:T286	R:R:V340	3.17	No	No	0	7	5
139	L:L:M8	R:R:F288	4.98	No	No	0	0	7
140	R:R:L289	R:R:W339	10.25	No	Yes	10	7	8
141	R:R:I363	R:R:L289	5.71	No	No	10	7	7
142	R:R:F291	R:R:Y290	6.19	No	Yes	0	5	9
143	R:R:T294	R:R:Y290	6.24	No	Yes	4	8	9
144	R:R:P332	R:R:Y290	2.78	Yes	Yes	4	9	9
145	R:R:V336	R:R:Y290	3.79	No	Yes	0	7	9
146	L:L:E4	R:R:L292	6.63	Yes	No	2	0	6
147	L:L:I5	R:R:L292	2.85	Yes	No	2	0	6
148	R:R:P332	R:R:T294	3.5	Yes	No	4	9	8
149	R:R:I367	R:R:Y296	3.63	No	No	0	7	7
150	R:R:Y296	R:R:Y421	13.9	No	Yes	0	7	8
151	L:L:V2	R:R:Y296	5.05	No	No	0	0	7
152	R:R:P332	R:R:Y297	5.56	Yes	Yes	4	9	6
153	R:R:F335	R:R:Y297	6.19	No	Yes	0	5	6
154	R:R:I367	R:R:Y297	4.84	No	Yes	4	7	6
155	R:R:S370	R:R:Y297	5.09	No	Yes	4	7	6
156	R:R:V301	R:R:W298	6.13	No	Yes	0	8	9
157	R:R:G328	R:R:W298	7.04	No	Yes	0	9	9
158	R:R:W298	R:R:W329	12.18	Yes	No	0	9	9
159	R:R:I299	R:R:N374	4.25	No	Yes	0	9	9
160	R:R:L300	R:R:N374	2.75	No	Yes	0	8	9
161	R:R:F324	R:R:V301	5.24	No	No	0	7	8
162	R:R:E302	R:R:L416	3.98	Yes	No	0	9	9
163	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
164	R:R:L304	R:R:L377	2.77	No	No	0	5	7
165	R:R:L309	R:R:Y305	14.07	No	No	0	8	8
166	R:R:F324	R:R:Y305	5.16	No	No	0	7	8
167	R:R:I310	R:R:L306	2.85	No	No	0	8	9
168	R:R:I381	R:R:L306	2.85	No	No	0	9	9
169	R:R:F417	R:R:L306	4.87	Yes	No	0	9	9
170	R:R:F311	R:R:H307	9.05	Yes	Yes	12	6	8
171	R:R:H307	R:R:L377	9	Yes	No	0	8	7
172	R:R:H307	R:R:N380	5.1	Yes	No	12	8	8
173	R:R:H307	R:R:I381	3.98	Yes	No	0	8	9
174	R:R:F315	R:R:L309	4.87	No	No	0	6	8
175	R:R:F311	R:R:I310	3.77	Yes	No	0	6	8
176	R:R:F311	R:R:N380	8.46	Yes	No	12	6	8
177	R:R:E317	R:R:F315	15.16	No	No	0	6	6
178	R:R:F315	R:R:Y320	4.13	No	No	0	6	4
179	R:R:K319	R:R:S316	3.06	No	No	0	6	7
180	R:R:L321	R:R:T325	2.95	No	No	0	6	5
181	R:R:F327	R:R:L331	3.65	No	No	0	5	4
182	R:R:L331	R:R:P332	3.28	No	Yes	0	4	9
183	R:R:F335	R:R:L331	3.65	No	No	0	5	4
184	R:R:F335	R:R:P366	10.11	No	No	0	5	9
185	R:R:W339	R:R:W352	4.69	Yes	Yes	0	8	8
186	R:R:I363	R:R:W339	3.52	No	Yes	10	7	8
187	R:R:V340	R:R:W352	8.58	No	Yes	0	5	8
188	R:R:K359	R:R:V342	3.04	Yes	No	0	3	5
189	R:R:A347	R:R:R343	2.77	No	No	0	7	8
190	R:R:R343	R:R:W352	24.99	No	Yes	0	8	8
191	R:R:A344	R:R:N348	6.25	No	No	0	4	7
192	R:R:K359	R:R:L346	4.23	Yes	No	0	3	3
193	R:R:C351	R:R:D353	10.89	No	Yes	3	9	5
194	L:L:Q16	R:R:L354	5.32	No	No	0	0	5
195	L:L:H9	R:R:S355	2.79	No	No	0	0	7
196	R:R:K359	R:R:S356	6.12	Yes	No	0	3	4
197	R:R:N358	R:R:W361	3.39	No	Yes	0	4	8
198	R:R:I362	R:R:K359	2.91	No	Yes	0	8	3
199	R:R:K360	R:R:W361	5.8	No	Yes	0	7	8
200	R:R:K360	R:R:Y429	5.97	No	No	0	7	6
201	R:R:Q364	R:R:W361	4.38	Yes	Yes	0	7	8
202	R:R:V365	R:R:W361	4.9	No	Yes	0	5	8
203	R:R:L368	R:R:Q364	10.65	No	Yes	0	4	7
204	L:L:A1	R:R:Q364	6.06	No	Yes	0	0	7
205	L:L:V2	R:R:Q364	7.16	No	Yes	2	0	7
206	L:L:I5	R:R:Q364	4.12	Yes	Yes	2	0	7
207	R:R:P366	R:R:V365	3.53	No	No	0	9	5
208	R:R:I367	R:R:S370	3.1	No	No	4	7	7
209	R:R:L368	R:R:M425	2.83	No	No	0	4	6
210	R:R:I371	R:R:S370	3.1	No	No	0	7	7
211	R:R:I371	R:R:Y421	4.84	No	Yes	0	7	8
212	R:R:I371	R:R:M425	7.29	No	No	0	7	6
213	R:R:L377	R:R:N374	2.75	No	Yes	0	7	9
214	R:R:F417	R:R:N374	4.83	Yes	Yes	0	9	9
215	R:R:F375	R:R:I379	5.02	No	No	0	7	5
216	R:R:F375	R:R:I422	11.3	No	No	0	7	5
217	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
218	R:R:F378	R:R:L413	6.09	Yes	No	11	9	9
219	R:R:F378	R:R:F417	4.29	Yes	Yes	11	9	9
220	R:R:F378	R:R:V419	9.18	Yes	No	0	9	7
221	R:R:N380	R:R:R383	4.82	No	No	0	8	8
222	R:R:E391	R:R:T387	2.82	No	No	0	7	7
223	R:R:L389	R:R:Q402	7.99	No	No	0	8	6
224	R:R:K405	R:R:L389	2.82	No	No	0	8	8
225	R:R:L389	R:R:L406	4.15	No	No	0	8	8
226	R:R:N393	R:R:Q402	11.88	No	No	0	7	6
227	R:R:Q401	R:R:T399	2.83	No	No	0	6	6
228	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
229	R:R:M414	R:R:T410	3.01	No	No	0	8	9
230	R:R:I458	R:R:V412	3.07	No	No	0	8	8
231	R:R:F417	R:R:L413	3.65	Yes	No	11	9	9
232	R:R:M414	R:R:V419	10.65	No	No	0	8	7
233	R:R:F417	R:R:L416	7.31	Yes	No	0	9	9
234	R:R:L416	R:R:Y459	11.72	No	No	0	9	8
235	R:R:G418	R:R:H420	3.18	No	Yes	5	9	8
236	R:R:G418	R:R:Y421	4.35	No	Yes	5	9	8
237	R:R:H420	R:R:Y421	8.71	Yes	Yes	5	8	8
238	R:R:F447	R:R:H420	12.44	No	Yes	0	5	8
239	R:R:H420	R:R:Q451	4.95	Yes	No	5	8	9
240	R:R:N448	R:R:Y421	5.81	No	Yes	0	6	8
241	R:R:Q451	R:R:Y421	11.27	No	Yes	5	9	8
242	R:R:F424	R:R:V423	6.55	No	No	13	7	6
243	R:R:V423	R:R:Y443	7.57	No	Yes	13	6	4
244	R:R:F424	R:R:Q440	5.86	No	No	0	7	6
245	R:R:F424	R:R:Y443	6.19	No	Yes	13	7	4
246	R:R:P428	R:R:T427	3.5	No	No	0	7	5
247	R:R:Q440	R:R:T427	4.25	No	No	0	6	5
248	L:L:A1	R:R:Y429	4	No	No	0	0	6
249	L:L:Q6	R:R:Y429	13.53	No	No	0	0	6
250	R:R:T430	R:R:W437	4.85	No	No	0	5	5
251	L:L:Q10	R:R:V432	4.3	No	No	0	0	5
252	R:R:M441	R:R:W437	5.82	Yes	No	0	6	5
253	L:L:Q10	R:R:W437	6.57	No	No	0	0	5
254	R:R:H442	R:R:Q438	3.71	No	No	0	5	4
255	L:L:Q6	R:R:Q440	10.24	No	No	0	0	6
256	R:R:M441	R:R:M445	2.89	Yes	No	8	6	6
257	L:L:Q6	R:R:M441	4.08	No	Yes	0	0	6
258	L:L:L7	R:R:M441	8.48	No	Yes	8	0	6
259	R:R:E444	R:R:Y443	4.49	No	Yes	0	7	4
260	R:R:F447	R:R:Y443	10.32	No	Yes	0	5	4
261	R:R:E444	R:R:N448	6.57	No	No	0	7	6
262	L:L:A3	R:R:E444	6.03	No	No	0	0	7
263	L:L:L7	R:R:M445	2.83	No	No	8	0	6
264	R:R:F450	R:R:S449	5.28	No	No	9	7	9
265	R:R:F450	R:R:F454	5.36	No	No	0	7	6
266	R:R:F453	R:R:I457	10.05	Yes	No	0	6	6
267	R:R:I458	R:R:Y459	3.63	No	No	0	8	8
268	R:R:F461	R:R:Q467	4.68	No	No	0	8	8
269	R:R:E465	R:R:N463	11.83	No	No	0	9	9
270	R:R:N463	R:R:V466	5.91	No	No	0	9	9
271	R:R:I470	R:R:V466	3.07	No	No	0	5	9
272	R:R:W474	R:R:W477	10.31	No	No	0	5	4
273	R:R:T478	R:R:W474	3.64	No	No	0	4	5
274	R:R:L481	R:R:W477	11.39	No	No	0	4	4
275	L:L:I5	L:L:V2	10.75	Yes	No	2	0	0
276	L:L:H9	L:L:I5	2.65	No	Yes	0	0	0
277	L:L:H9	L:L:M8	3.94	No	No	0	0	0
278	L:L:I15	L:L:R11	5.01	No	Yes	0	0	0
279	L:L:I15	L:L:W14	3.52	No	No	0	0	0
280	L:L:D17	L:L:R20	7.15	No	No	0	0	0
281	L:L:F23	L:L:R19	11.76	No	Yes	0	0	0
282	L:L:H25	L:L:L27	11.57	No	No	0	0	0
283	L:L:H25	L:L:I28	7.95	No	No	0	0	0
284	R:R:F238	R:R:S196	2.64	No	No	0	7	7
285	R:R:F230	R:R:V455	2.62	Yes	No	0	8	9
286	R:R:F287	R:R:V283	2.62	No	No	0	3	4
287	R:R:F311	R:R:V384	2.62	Yes	No	0	6	8
288	R:R:F375	R:R:V419	2.62	No	No	0	7	7
289	R:R:R383	R:R:V384	2.62	No	No	0	8	8
290	R:R:C148	R:R:W154	2.61	No	Yes	1	9	9
291	R:R:D149	R:R:E155	2.6	Yes	No	0	5	4
292	R:R:A344	R:R:W352	2.59	No	Yes	0	4	8
293	R:R:R390	R:R:T387	2.59	No	No	0	6	7
294	R:R:H223	R:R:N220	2.55	No	No	0	9	9
295	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
296	R:R:T192	R:R:Y191	2.5	No	No	0	7	7
297	R:R:E302	R:R:H223	2.46	Yes	No	0	9	9
298	R:R:V127	R:R:W118	2.45	No	Yes	0	7	9
299	R:R:F238	R:R:L199	2.44	No	No	0	7	7
300	R:R:I362	R:R:W339	2.35	No	Yes	0	8	8
301	R:R:N166	R:R:Y145	2.33	No	No	0	7	4
302	R:R:E469	R:R:F212	2.33	No	Yes	0	9	7
303	R:R:L321	R:R:W322	2.28	No	No	0	6	3
304	R:R:E35	R:R:Y278	2.24	No	Yes	0	5	4
305	R:R:H216	R:R:Y221	2.18	No	No	0	8	7
306	R:R:H225	R:R:Y221	2.18	No	No	0	8	7
307	R:R:F453	R:R:F454	2.14	Yes	No	0	6	6
308	R:R:R214	R:R:R476	2.13	No	No	0	7	7
309	R:R:R147	R:R:W164	2	No	No	0	3	5
310	R:R:C108	R:R:G152	1.96	No	No	1	9	9
311	R:R:C131	R:R:G142	1.96	No	No	0	9	5
312	R:R:C148	R:R:G152	1.96	No	No	1	9	9
313	R:R:C131	R:R:P132	1.88	No	No	0	9	9
314	R:R:A122	R:R:P123	1.87	No	No	0	1	7
315	R:R:A293	R:R:P332	1.87	No	Yes	0	6	9
316	R:R:G357	R:R:S356	1.86	No	No	0	6	4
317	R:R:G434	R:R:S433	1.86	No	No	0	5	3
318	R:R:G194	R:R:V193	1.84	No	No	0	9	6
319	R:R:G350	R:R:T349	1.82	No	No	0	5	5
320	R:R:P119	R:R:V129	1.77	No	Yes	0	6	5
321	R:R:P415	R:R:V455	1.77	No	No	0	9	9
322	R:R:A456	R:R:S201	1.71	No	No	0	8	8
323	R:R:G464	R:R:N463	1.7	No	No	0	7	9
324	R:R:C217	R:R:T218	1.69	No	No	0	8	7
325	R:R:D149	R:R:G152	1.68	Yes	No	0	5	9
326	R:R:A274	R:R:T273	1.68	No	No	0	5	3
327	R:R:A347	R:R:T349	1.68	No	No	0	7	5
328	R:R:L120	R:R:P110	1.64	No	No	0	4	6
329	R:R:C462	R:R:I457	1.64	No	No	0	6	6
330	R:R:S341	R:R:V342	1.62	No	No	0	5	5
331	R:R:A210	R:R:M224	1.61	No	No	0	4	5
332	R:R:S196	R:R:T192	1.6	No	No	0	7	7
333	R:R:V338	R:R:V342	1.6	No	No	0	5	5
334	R:R:S475	R:R:T478	1.6	No	No	0	4	4
335	R:R:T203	R:R:V204	1.59	No	No	0	3	5
336	R:R:A234	R:R:L199	1.58	No	No	0	8	7
337	L:L:A12	R:R:D353	1.54	No	Yes	0	0	5
338	R:R:I376	R:R:V372	1.54	No	No	0	4	4
339	R:R:I422	R:R:V372	1.54	No	No	0	5	4
340	R:R:K472	R:R:S475	1.53	No	No	0	7	4
341	R:R:G124	R:R:R150	1.5	No	No	0	7	1
342	R:R:L250	R:R:S246	1.5	No	No	0	3	4
343	R:R:L385	R:R:S409	1.5	No	No	0	8	9
344	R:R:L232	R:R:V235	1.49	No	No	0	8	4
345	R:R:D149	R:R:S153	1.47	Yes	No	0	5	4
346	R:R:L321	R:R:T218	1.47	No	No	0	6	7
347	R:R:L250	R:R:T249	1.47	No	No	0	3	4
348	R:R:L406	R:R:T410	1.47	No	No	0	8	9
349	R:R:L436	R:R:T427	1.47	No	No	0	4	5
350	R:R:L436	R:R:T430	1.47	No	No	0	4	5
351	R:R:L479	R:R:T478	1.47	No	No	0	4	4
352	R:R:E169	R:R:S168	1.44	No	No	0	5	6
353	R:R:Q438	R:R:S433	1.44	No	No	0	4	3
354	R:R:L199	R:R:M231	1.41	No	No	0	7	8
355	R:R:L228	R:R:M231	1.41	No	No	0	4	8
356	R:R:G330	R:R:W329	1.41	No	No	0	7	9
357	R:R:C462	R:R:F461	1.4	No	No	0	6	8
358	R:R:L300	R:R:L373	1.38	No	No	0	8	7
359	R:R:L385	R:R:L406	1.38	No	No	0	8	8
360	R:R:L407	R:R:L411	1.38	No	No	0	8	8
361	R:R:K50	R:R:Q47	1.36	No	No	0	4	6
362	R:R:E36	R:R:L40	1.33	No	No	0	6	5
363	R:R:L40	R:R:Q37	1.33	No	Yes	0	5	7
364	R:R:A274	R:R:Y278	1.33	No	Yes	0	5	4
365	R:R:A333	R:R:Y290	1.33	No	Yes	0	5	9
366	R:R:F212	R:R:S473	1.32	Yes	No	0	7	4
367	R:R:R476	R:R:S475	1.32	No	No	0	7	4
368	R:R:S308	R:R:Y320	1.27	No	No	0	7	4
369	R:R:V171	R:R:Y167	1.26	No	No	0	3	5
370	R:R:I190	R:R:R186	1.25	No	No	0	6	5
371	R:R:H42	R:R:Q45	1.24	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M32	6.7225	4	3	6
2	R:R:Q37	4.545	4	0	7
3	R:R:W112	6.772	5	6	7
4	R:R:W118	9.00333	6	1	9
5	R:R:V129	3.6675	4	1	5
6	R:R:R146	8.314	5	1	8
7	R:R:D149	2.785	4	0	5
8	R:R:W154	7.5075	4	1	9
9	R:R:E177	4.25	4	7	1
10	R:R:F212	3.726	5	0	7
11	R:R:F227	4.415	4	0	9
12	R:R:F230	5.254	5	0	8
13	R:R:R233	7.32	5	2	8
14	R:R:Y278	2.8775	4	3	4
15	R:R:Y290	4.066	5	4	9
16	R:R:Y297	5.42	4	4	6
17	R:R:W298	9.5125	4	0	9
18	R:R:E302	6.61	4	0	9
19	R:R:H307	6.7825	4	12	8
20	R:R:F311	5.975	4	12	6
21	R:R:P332	3.398	5	4	9
22	R:R:W339	5.2025	4	10	8
23	R:R:W352	10.2125	4	0	8
24	R:R:D353	4.834	5	3	5
25	R:R:K359	4.075	4	0	3
26	R:R:W361	4.6175	4	0	8
27	R:R:Q364	6.474	5	2	7
28	R:R:N374	3.645	4	0	9
29	R:R:F378	6.8575	4	11	9
30	R:R:F417	5.16167	6	11	9
31	R:R:H420	7.32	4	5	8
32	R:R:Y421	8.14667	6	5	8
33	R:R:M441	4.82	5	8	6
34	R:R:Y443	7.1425	4	13	4
35	R:R:F453	6.34	4	0	6
36	L:L:E4	7.555	4	2	0
37	L:L:I5	5.0925	4	2	0
38	L:L:R11	9.1075	4	0	0
39	L:L:R19	8.1575	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R19	R:R:Q37	14.4399	4.67	Yes	Yes	0	0	7
2	L:L:R20	R:R:Q37	20.9873	9.35	No	Yes	0	0	7
3	R:R:D149	R:R:G152	18.4907	1.68	Yes	No	0	5	9
4	R:R:D149	R:R:E155	21.4357	2.6	Yes	No	0	5	4
5	R:R:E155	R:R:R147	22.4087	12.79	No	No	0	4	3
6	R:R:R147	R:R:V126	24.3416	7.85	No	No	0	3	4
7	R:R:V126	R:R:Y145	25.3015	3.79	No	No	0	4	4
8	R:R:N166	R:R:Y145	27.2082	2.33	No	No	0	7	4
9	R:R:N166	R:R:S168	28.1551	7.45	No	No	0	7	6
10	R:R:E169	R:R:S168	29.0976	1.44	No	No	0	5	6
11	R:R:E169	R:R:G142	30.0357	4.91	No	No	0	5	5
12	R:R:C131	R:R:G142	30.9695	1.96	No	No	0	9	5
13	R:R:C131	R:R:P132	32.824	1.88	No	No	0	9	9
14	R:R:I135	R:R:P132	34.6611	3.39	No	No	0	7	9
15	L:L:R20	R:R:I135	37.3776	10.02	No	No	0	0	7
16	R:R:C148	R:R:G152	15.4412	1.96	No	No	1	9	9
17	R:R:C148	R:R:W154	14.5031	2.61	No	Yes	1	9	9
18	L:L:D17	L:L:R20	50.1045	7.15	No	No	0	0	0
19	L:L:D17	R:R:E177	52.1092	6.5	No	Yes	0	0	1
20	L:L:L7	R:R:F184	13.2907	3.65	No	No	0	0	6
21	L:L:R11	R:R:F184	14.8535	14.97	Yes	No	0	0	6
22	L:L:R11	R:R:L244	32.0317	13.36	Yes	No	0	0	5
23	R:R:K240	R:R:L244	31.1719	12.69	No	No	0	7	5
24	R:R:D353	R:R:K240	28.9321	4.15	Yes	No	0	5	7
25	R:R:C351	R:R:D353	26.0633	10.89	No	Yes	3	9	5
26	R:R:C351	R:R:M32	25.604	4.86	No	Yes	3	9	6
27	L:L:W14	R:R:E177	58.6196	4.36	No	Yes	0	0	1
28	L:L:I15	L:L:W14	59.9909	3.52	No	No	0	0	0
29	L:L:I15	L:L:R11	60.7309	5.01	No	Yes	0	0	0
30	R:R:D241	R:R:Y191	90.1093	11.49	No	No	0	8	7
31	L:L:R11	R:R:Y191	86.5047	3.09	Yes	No	0	0	7
32	R:R:F453	R:R:S201	13.4779	7.93	Yes	No	0	6	8
33	R:R:A456	R:R:S201	14.6772	1.71	No	No	0	8	8
34	R:R:A456	R:R:L202	15.8722	3.15	No	No	0	8	9
35	R:R:F230	R:R:L202	17.0889	3.65	Yes	No	0	8	9
36	R:R:F230	R:R:N295	96.5652	8.46	Yes	No	0	8	8
37	R:R:N295	R:R:R233	100	7.23	No	Yes	0	8	8
38	R:R:R233	R:R:Y195	43.7878	9.26	Yes	No	2	8	7
39	R:R:I237	R:R:Y195	43.692	9.67	No	No	2	7	7
40	R:R:D241	R:R:I237	90.5577	4.2	No	No	0	8	7
41	L:L:E4	R:R:R233	43.7486	11.63	Yes	Yes	2	0	8
42	L:L:E4	R:R:I237	47.3358	4.1	Yes	No	2	0	7
43	R:R:F230	R:R:L226	82.8893	8.53	Yes	No	0	8	9
44	R:R:F212	R:R:L215	17.4873	7.31	Yes	No	0	7	9
45	R:R:E465	R:R:L215	18.4776	5.3	No	No	0	9	9
46	R:R:E465	R:R:R219	23.3599	5.82	No	No	0	9	9
47	R:R:N220	R:R:R219	24.3241	10.85	No	No	0	9	9
48	R:R:H223	R:R:N220	28.1377	2.55	No	No	0	9	9
49	R:R:E302	R:R:H223	29.0801	2.46	Yes	No	0	9	9
50	R:R:E302	R:R:L226	82.9524	15.9	Yes	No	0	9	9
51	R:R:E469	R:R:F212	11.4601	2.33	No	Yes	0	9	7
52	R:R:E469	R:R:R214	10.4392	10.47	No	No	0	9	7
53	R:R:L309	R:R:Y305	10.4458	14.07	No	No	0	8	8
54	R:R:I222	R:R:Y305	20.4584	8.46	No	No	0	9	8
55	R:R:E302	R:R:I222	21.4357	4.1	Yes	No	0	9	9
56	R:R:N295	R:R:S229	13.9045	5.96	No	No	0	8	9
57	R:R:S229	R:R:T294	12.962	3.2	No	No	0	9	8
58	R:R:N448	R:R:R233	19.4941	3.62	No	Yes	0	6	8
59	R:R:G350	R:R:M32	21.2072	3.49	No	Yes	3	5	6
60	R:R:G350	R:R:T349	20.4149	1.82	No	No	0	5	5
61	R:R:A347	R:R:T349	19.4354	1.68	No	No	0	7	5
62	R:R:A347	R:R:R343	18.4515	2.77	No	No	0	7	8
63	R:R:R343	R:R:W352	17.4633	24.99	No	Yes	0	8	8
64	L:L:I5	R:R:L292	12.7705	2.85	Yes	No	2	0	6
65	R:R:W339	R:R:W352	11.4427	4.69	Yes	Yes	0	8	8
66	L:L:Q6	R:R:Y429	10.8115	13.53	No	No	0	0	6
67	L:L:Q6	R:R:M441	17.546	4.08	No	Yes	0	0	6
68	R:R:F417	R:R:L416	40.9495	7.31	Yes	No	0	9	9
69	R:R:E302	R:R:L416	44.4408	3.98	Yes	No	0	9	9
70	R:R:F417	R:R:L306	11.2773	4.87	Yes	No	0	9	9
71	R:R:F378	R:R:V419	17.5003	9.18	Yes	No	0	9	7
72	R:R:F378	R:R:F417	19.4354	4.29	Yes	Yes	11	9	9
73	R:R:M414	R:R:T410	10.4458	3.01	No	No	0	8	9
74	R:R:M414	R:R:V419	11.4666	10.65	No	No	0	8	7
75	R:R:E444	R:R:N448	10.2434	6.57	No	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M32	R:R:Y278	3.59	3	Yes	Yes	6	4	1	2
R:R:G350	R:R:M32	3.49	3	No	Yes	5	6	2	1
R:R:C351	R:R:M32	4.86	3	No	Yes	9	6	2	1
L:L:Q16	R:R:M32	14.95	0	No	Yes	0	6	0	1
R:R:Q37	R:R:T33	2.83	0	Yes	No	7	7	1	1
L:L:Q16	R:R:T33	4.25	0	No	No	0	7	0	1
L:L:A18	R:R:K34	3.21	0	No	No	0	4	0	1
L:L:R19	R:R:K34	7.43	0	Yes	No	0	4	0	1
L:L:R19	R:R:Q37	4.67	0	Yes	Yes	0	7	0	1
L:L:R20	R:R:Q37	9.35	0	No	Yes	0	7	0	1
R:R:H42	R:R:I38	2.65	0	No	No	4	7	2	1
L:L:R19	R:R:I38	8.77	0	Yes	No	0	7	0	1
L:L:F23	R:R:I115	3.77	0	No	No	0	5	0	1
R:R:I135	R:R:P132	3.39	0	No	No	7	9	1	2
R:R:F138	R:R:I135	13.82	0	No	No	4	7	1	1
L:L:R20	R:R:I135	10.02	0	No	No	0	7	0	1
R:R:D137	R:R:Y136	3.45	0	No	No	5	4	1	2
L:L:D17	R:R:D137	6.65	0	No	No	0	5	0	1
L:L:L24	R:R:F138	9.74	0	No	No	0	4	0	1
L:L:H25	R:R:Y167	9.8	0	No	No	0	5	0	1
R:R:L174	R:R:V171	4.47	7	No	No	3	3	1	2
R:R:E177	R:R:L174	2.65	7	Yes	No	1	3	1	1
L:L:R21	R:R:L174	7.29	7	No	No	0	3	0	1
L:L:W14	R:R:E177	4.36	0	No	Yes	0	1	0	1
L:L:D17	R:R:E177	6.5	0	No	Yes	0	1	0	1
L:L:R21	R:R:E177	3.49	7	No	Yes	0	1	0	1
R:R:R179	R:R:T178	5.17	0	No	No	3	3	2	1
L:L:R21	R:R:T178	3.88	7	No	No	0	3	0	1
L:L:W14	R:R:R181	6	0	No	No	0	3	0	1
R:R:A188	R:R:F184	2.77	0	No	No	5	6	2	1
L:L:L7	R:R:F184	3.65	8	No	No	0	6	0	1
L:L:R11	R:R:F184	14.97	0	Yes	No	0	6	0	1
R:R:L187	R:R:M441	2.83	0	No	Yes	5	6	2	1
R:R:I190	R:R:M445	2.92	0	No	No	6	6	2	1
R:R:D241	R:R:Y191	11.49	0	No	No	8	7	2	1
L:L:R11	R:R:Y191	3.09	0	Yes	No	0	7	0	1
R:R:R233	R:R:Y195	9.26	2	Yes	No	8	7	1	1
R:R:I237	R:R:Y195	9.67	2	No	No	7	7	1	1
L:L:E4	R:R:Y195	7.86	2	Yes	No	0	7	0	1
R:R:L292	R:R:R233	4.86	2	No	Yes	6	8	1	1
R:R:N295	R:R:R233	7.23	0	No	Yes	8	8	2	1
R:R:N448	R:R:R233	3.62	0	No	Yes	6	8	2	1
L:L:E4	R:R:R233	11.63	2	Yes	Yes	0	8	0	1
R:R:D241	R:R:I237	4.2	0	No	No	8	7	2	1
L:L:E4	R:R:I237	4.1	2	Yes	No	0	7	0	1
R:R:K240	R:R:L244	12.69	0	No	No	7	5	2	1
R:R:D353	R:R:K240	4.15	3	Yes	No	5	7	1	2
L:L:R11	R:R:L244	13.36	0	Yes	No	0	5	0	1
R:R:G350	R:R:Y278	4.35	3	No	Yes	5	4	2	2
R:R:C281	R:R:C351	7.28	3	No	No	9	9	2	2
R:R:C281	R:R:D353	4.67	3	No	Yes	9	5	2	1
R:R:D353	R:R:V285	2.92	3	Yes	No	5	6	1	2
L:L:M8	R:R:F288	4.98	0	No	No	0	7	0	1
L:L:E4	R:R:L292	6.63	2	Yes	No	0	6	0	1
L:L:I5	R:R:L292	2.85	2	Yes	No	0	6	0	1
R:R:I367	R:R:Y296	3.63	4	No	No	7	7	2	1
R:R:Y296	R:R:Y421	13.9	0	No	Yes	7	8	1	2
L:L:V2	R:R:Y296	5.05	2	No	No	0	7	0	1
R:R:C351	R:R:D353	10.89	3	No	Yes	9	5	2	1
L:L:Q16	R:R:L354	5.32	0	No	No	0	5	0	1
L:L:H9	R:R:S355	2.79	0	No	No	0	7	0	1
R:R:K360	R:R:W361	5.8	0	No	Yes	7	8	2	2
R:R:K360	R:R:Y429	5.97	0	No	No	7	6	2	1
R:R:Q364	R:R:W361	4.38	2	Yes	Yes	7	8	1	2
R:R:L368	R:R:Q364	10.65	0	No	Yes	4	7	2	1
L:L:A1	R:R:Q364	6.06	0	No	Yes	0	7	0	1
L:L:V2	R:R:Q364	7.16	2	No	Yes	0	7	0	1
L:L:I5	R:R:Q364	4.12	2	Yes	Yes	0	7	0	1
R:R:N448	R:R:Y421	5.81	0	No	Yes	6	8	2	2
R:R:F424	R:R:Q440	5.86	13	No	No	7	6	2	1
R:R:F424	R:R:Y443	6.19	13	No	Yes	7	4	2	2
R:R:Q440	R:R:T427	4.25	0	No	No	6	5	1	2
L:L:A1	R:R:Y429	4	0	No	No	0	6	0	1
L:L:Q6	R:R:Y429	13.53	0	No	No	0	6	0	1
R:R:T430	R:R:W437	4.85	0	No	No	5	5	2	1
L:L:Q10	R:R:V432	4.3	0	No	No	0	5	0	1
R:R:M441	R:R:W437	5.82	8	Yes	No	6	5	1	1
L:L:Q10	R:R:W437	6.57	0	No	No	0	5	0	1
L:L:Q6	R:R:Q440	10.24	0	No	No	0	6	0	1
R:R:M441	R:R:M445	2.89	8	Yes	No	6	6	1	1
L:L:Q6	R:R:M441	4.08	0	No	Yes	0	6	0	1
L:L:L7	R:R:M441	8.48	8	No	Yes	0	6	0	1
R:R:E444	R:R:Y443	4.49	0	No	Yes	7	4	1	2
R:R:E444	R:R:N448	6.57	0	No	No	7	6	1	2
L:L:A3	R:R:E444	6.03	0	No	No	0	7	0	1
L:L:L7	R:R:M445	2.83	8	No	No	0	6	0	1
R:R:T192	R:R:Y191	2.5	0	No	No	7	7	2	1
L:L:A12	R:R:D353	1.54	0	No	Yes	0	5	0	1
R:R:L40	R:R:Q37	1.33	0	No	Yes	5	7	2	1
R:R:V171	R:R:Y167	1.26	0	No	No	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6NBI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.65
Number of Linked Nodes	344
Number of Links	371
Number of Hubs	39
Number of Links mediated by Hubs	156
Number of Communities	13
Number of Nodes involved in Communities	57
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	78628
Length Of Smallest Path	3
Average Path Length	18.9568
Length of Longest Path	48
Minimum Path Strength	1.33
Average Path Strength	6.31473
Maximum Path Strength	16.785
Minimum Path Correlation	0.7
Average Path Correlation	0.96294
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	63.6566
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.1707
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • positive regulation of cellular process • cell division • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • midbody • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • response to prostaglandin • response to endogenous stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • response to hormone • response to prostaglandin E • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>6NBI_nogp_Chain_R M T K E E Q I F L L H R A Q A Q C E K R L K R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L T W A N Y S E C V K F L T N E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T L T A A A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N A G T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L D F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6NBI_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.