psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q6	L:L:S1	4.33	Yes	No	0	0	0
2	L:L:I5	L:L:V2	10.75	No	Yes	1	0	0
3	L:L:V2	R:R:Q364	7.16	Yes	Yes	1	0	7
4	L:L:V2	R:R:I367	4.61	Yes	No	0	0	7
5	L:L:S3	R:R:Q440	4.33	No	Yes	1	0	6
6	L:L:S3	R:R:M441	4.6	No	Yes	1	0	6
7	L:L:S3	R:R:E444	11.5	No	Yes	1	0	7
8	L:L:E4	R:R:Y195	10.1	No	Yes	0	0	7
9	L:L:E4	R:R:M445	8.12	No	No	0	0	6
10	L:L:H9	L:L:I5	6.63	Yes	No	1	0	0
11	L:L:I5	R:R:Q364	6.86	No	Yes	1	0	7
12	L:L:N10	L:L:Q6	6.6	No	Yes	1	0	0
13	L:L:Q6	R:R:Y429	24.8	Yes	Yes	1	0	6
14	L:L:Q6	R:R:Q440	5.12	Yes	Yes	1	0	6
15	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
16	L:L:L7	R:R:L187	4.15	No	Yes	1	0	5
17	L:L:L7	R:R:M441	4.24	No	Yes	1	0	6
18	L:L:H9	R:R:S355	5.58	Yes	No	1	0	7
19	L:L:H9	R:R:K360	5.24	Yes	Yes	1	0	7
20	L:L:H9	R:R:Y429	7.62	Yes	Yes	1	0	6
21	L:L:N10	R:R:V432	4.43	No	No	1	0	5
22	L:L:N10	R:R:W437	5.65	No	Yes	1	0	5
23	L:L:L11	R:R:F184	8.53	No	No	0	0	6
24	L:L:L11	R:R:Y245	12.89	No	No	0	0	4
25	L:L:H14	L:L:M18	10.51	Yes	No	0	0	0
26	L:L:H14	R:R:R181	6.77	Yes	No	0	0	3
27	L:L:H14	R:R:F184	7.92	Yes	No	0	0	6
28	L:L:N16	R:R:T33	4.39	No	No	0	0	7
29	L:L:N16	R:R:L354	4.12	No	No	0	0	5
30	L:L:R20	R:R:Q37	8.18	Yes	Yes	4	0	7
31	L:L:R20	R:R:Y136	25.72	Yes	No	4	0	4
32	L:L:R20	R:R:D137	11.91	Yes	No	0	0	5
33	L:L:V21	R:R:D137	5.84	No	No	0	0	5
34	L:L:W23	R:R:K34	6.96	Yes	No	4	0	4
35	L:L:W23	R:R:Q37	4.38	Yes	Yes	4	0	7
36	L:L:W23	R:R:I38	9.4	Yes	No	4	0	7
37	L:L:W23	R:R:L41	6.83	Yes	No	0	0	8
38	L:L:L24	L:L:L28	5.54	No	Yes	2	0	0
39	L:L:L24	R:R:I135	4.28	No	Yes	2	0	7
40	L:L:L24	R:R:F138	7.31	No	Yes	2	0	4
41	L:L:R25	R:R:L174	7.29	No	No	0	0	3
42	L:L:K27	R:R:L41	5.64	No	No	0	0	8
43	L:L:K27	R:R:I115	4.36	No	No	0	0	5
44	L:L:L28	R:R:F138	7.31	Yes	Yes	2	0	4
45	L:L:L28	R:R:Y167	4.69	Yes	Yes	2	0	5
46	L:L:V31	R:R:D113	7.3	No	No	2	0	9
47	L:L:V31	R:R:I115	4.61	No	No	0	0	5
48	L:L:V31	R:R:Y167	6.31	No	Yes	2	0	5
49	L:L:H32	R:R:R162	5.64	No	Yes	0	0	3
50	L:L:?35	L:L:F34	9.04	No	No	0	0	0
51	L:L:F34	R:R:E111	9.33	No	Yes	0	0	7
52	L:L:F34	R:R:H114	6.79	No	No	0	0	4
53	R:R:E36	R:R:M32	6.77	No	No	0	6	6
54	R:R:M32	R:R:Q37	8.16	No	Yes	4	6	7
55	R:R:M32	R:R:Y136	4.79	No	No	4	6	4
56	R:R:E36	R:R:T33	16.93	No	No	0	6	7
57	R:R:I38	R:R:K34	4.36	No	No	4	7	4
58	R:R:Q37	R:R:Y136	6.76	Yes	No	4	7	4
59	R:R:A44	R:R:Y134	6.67	No	Yes	0	7	5
60	R:R:Q45	R:R:W112	21.9	No	No	0	7	7
61	R:R:C48	R:R:W112	9.14	No	No	0	8	7
62	R:R:C117	R:R:C48	7.28	No	No	0	9	8
63	R:R:L52	R:R:P110	4.93	No	No	0	4	6
64	R:R:C108	R:R:C148	7.28	No	No	0	9	9
65	R:R:C108	R:R:W154	18.28	No	Yes	0	9	9
66	R:R:E111	R:R:R146	11.63	Yes	Yes	2	7	8
67	R:R:E111	R:R:W154	9.81	Yes	Yes	2	7	9
68	R:R:E111	R:R:T163	4.23	Yes	No	2	7	5
69	R:R:D113	R:R:W118	6.7	No	Yes	2	9	9
70	R:R:D113	R:R:Y167	6.9	No	Yes	2	9	5
71	R:R:L116	R:R:W118	7.97	Yes	Yes	2	5	9
72	R:R:L116	R:R:V129	5.96	Yes	Yes	2	5	5
73	R:R:L116	R:R:P132	11.49	Yes	Yes	2	5	9
74	R:R:L116	R:R:Y167	5.86	Yes	Yes	2	5	5
75	R:R:V129	R:R:W118	8.58	Yes	Yes	2	5	9
76	R:R:R146	R:R:W118	40.98	Yes	Yes	2	8	9
77	R:R:W118	R:R:Y167	4.82	Yes	Yes	2	9	5
78	R:R:R147	R:R:V126	11.77	No	No	0	3	4
79	R:R:V127	R:R:W154	7.36	No	Yes	0	7	9
80	R:R:H143	R:R:P130	9.15	No	No	0	3	5
81	R:R:C131	R:R:C170	7.28	No	No	0	9	9
82	R:R:P132	R:R:Y134	12.52	Yes	Yes	2	9	5
83	R:R:I135	R:R:P132	5.08	Yes	Yes	2	7	9
84	R:R:F138	R:R:P132	5.78	Yes	Yes	2	4	9
85	R:R:D133	R:R:Y134	8.05	No	Yes	0	2	5
86	R:R:I135	R:R:Y134	4.84	Yes	Yes	2	7	5
87	R:R:F138	R:R:I135	18.84	Yes	Yes	2	4	7
88	R:R:F138	R:R:Y167	4.13	Yes	Yes	2	4	5
89	R:R:C170	R:R:F138	12.57	No	Yes	0	9	4
90	R:R:K141	R:R:N139	4.2	No	No	0	3	4
91	R:R:G142	R:R:H143	4.77	No	No	0	5	3
92	R:R:E169	R:R:G142	4.91	No	No	0	5	5
93	R:R:A144	R:R:Y167	5.34	No	Yes	0	7	5
94	R:R:E169	R:R:Y145	6.73	No	Yes	0	5	4
95	R:R:R146	R:R:W154	13.99	Yes	Yes	2	8	9
96	R:R:R146	R:R:T163	5.17	Yes	No	2	8	5
97	R:R:E155	R:R:R147	4.65	No	No	0	4	3
98	R:R:R147	R:R:W164	5	No	No	0	3	5
99	R:R:H160	R:R:V157	9.69	No	No	6	4	4
100	R:R:R162	R:R:V157	18.31	Yes	No	6	3	4
101	R:R:G159	R:R:H160	4.77	No	No	0	3	4
102	R:R:H160	R:R:R162	21.44	No	Yes	6	4	3
103	R:R:N166	R:R:S168	8.94	No	No	0	7	6
104	R:R:L174	R:R:V171	4.47	No	No	0	3	3
105	R:R:E177	R:R:T175	8.47	No	No	0	1	1
106	R:R:E180	R:R:V432	14.26	No	No	0	3	5
107	R:R:D185	R:R:R181	8.34	No	No	0	2	3
108	R:R:Q438	R:R:V183	8.6	No	No	0	4	4
109	R:R:F184	R:R:W437	6.01	No	Yes	0	6	5
110	R:R:H442	R:R:R186	6.77	No	No	0	5	5
111	R:R:L187	R:R:M441	5.65	Yes	Yes	1	5	6
112	R:R:H442	R:R:L187	10.29	No	Yes	0	5	5
113	R:R:L187	R:R:M445	4.24	Yes	No	0	5	6
114	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
115	R:R:T192	R:R:Y191	4.99	No	Yes	0	7	7
116	R:R:I237	R:R:Y191	4.84	No	Yes	7	7	7
117	R:R:D241	R:R:Y191	6.9	No	Yes	7	8	7
118	R:R:F450	R:R:G194	9.03	No	No	0	7	9
119	R:R:R233	R:R:Y195	12.35	Yes	Yes	0	8	7
120	R:R:A234	R:R:Y195	5.34	No	Yes	0	8	7
121	R:R:I237	R:R:Y195	6.04	No	Yes	0	7	7
122	R:R:S449	R:R:Y195	6.36	No	Yes	0	9	7
123	R:R:F453	R:R:V197	5.24	No	No	0	6	5
124	R:R:F453	R:R:S201	5.28	No	No	0	6	8
125	R:R:F227	R:R:L202	8.53	Yes	No	0	9	9
126	R:R:F230	R:R:L202	6.09	Yes	No	0	8	9
127	R:R:M231	R:R:T203	4.52	No	No	0	8	3
128	R:R:A205	R:R:F227	4.16	No	Yes	0	9	9
129	R:R:L228	R:R:V206	5.96	No	No	0	4	5
130	R:R:L209	R:R:N220	8.24	No	No	0	7	9
131	R:R:L209	R:R:M224	5.65	No	No	0	7	5
132	R:R:F212	R:R:L215	6.09	Yes	No	8	7	9
133	R:R:E469	R:R:F212	16.32	Yes	Yes	8	9	7
134	R:R:F212	R:R:S473	5.28	Yes	No	0	7	4
135	R:R:E469	R:R:R214	12.79	Yes	No	0	9	7
136	R:R:E465	R:R:L215	6.63	No	No	0	9	9
137	R:R:E469	R:R:L215	5.3	Yes	No	8	9	9
138	R:R:H216	R:R:Y221	9.8	No	No	0	8	7
139	R:R:C217	R:R:R219	5.57	No	Yes	3	8	9
140	R:R:C217	R:R:N220	4.72	No	No	3	8	9
141	R:R:T218	R:R:Y305	4.99	No	Yes	3	7	8
142	R:R:E317	R:R:T218	14.11	No	No	3	6	7
143	R:R:N220	R:R:R219	12.05	No	Yes	3	9	9
144	R:R:H223	R:R:R219	5.64	No	Yes	0	9	9
145	R:R:R219	R:R:Y305	4.12	Yes	Yes	3	9	8
146	R:R:N463	R:R:R219	7.23	Yes	Yes	0	9	9
147	R:R:L321	R:R:Y221	4.69	No	No	0	6	7
148	R:R:E302	R:R:I222	5.47	Yes	No	0	9	9
149	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
150	R:R:E302	R:R:H223	12.31	Yes	No	0	9	9
151	R:R:H223	R:R:Y459	4.36	No	Yes	0	9	8
152	R:R:H225	R:R:W298	14.81	No	Yes	9	8	9
153	R:R:H225	R:R:T325	8.21	No	No	0	8	5
154	R:R:H225	R:R:W329	5.29	No	No	9	8	9
155	R:R:F227	R:R:L226	4.87	Yes	Yes	0	9	9
156	R:R:L226	R:R:S229	4.5	Yes	No	0	9	9
157	R:R:F230	R:R:L226	7.31	Yes	Yes	0	8	9
158	R:R:E302	R:R:L226	17.23	Yes	Yes	0	9	9
159	R:R:C460	R:R:F227	4.19	No	Yes	0	9	9
160	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
161	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
162	R:R:F230	R:R:N295	18.12	Yes	Yes	1	8	8
163	R:R:F230	R:R:I299	6.28	Yes	Yes	1	8	9
164	R:R:F230	R:R:Q451	10.54	Yes	Yes	1	8	9
165	R:R:F230	R:R:G452	6.02	Yes	No	0	8	9
166	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
167	R:R:F291	R:R:L232	20.7	No	No	0	5	8
168	R:R:L292	R:R:R233	9.72	No	Yes	0	6	8
169	R:R:N295	R:R:R233	14.46	Yes	Yes	1	8	8
170	R:R:R233	R:R:Y296	14.4	Yes	Yes	1	8	7
171	R:R:R233	R:R:Y421	4.12	Yes	Yes	1	8	8
172	R:R:F291	R:R:S236	7.93	No	No	0	5	7
173	R:R:D241	R:R:I237	4.2	No	No	7	8	7
174	R:R:D241	R:R:K240	5.53	No	No	0	8	7
175	R:R:K240	R:R:L244	4.23	No	Yes	0	7	5
176	R:R:F288	R:R:K240	19.85	No	No	0	7	7
177	R:R:A284	R:R:V243	5.09	No	No	0	6	5
178	R:R:L244	R:R:Y245	10.55	Yes	No	0	5	4
179	R:R:L244	R:R:V285	4.47	Yes	No	0	5	6
180	R:R:D353	R:R:L244	14.93	No	Yes	0	5	5
181	R:R:C281	R:R:C351	7.28	No	No	0	9	9
182	R:R:N348	R:R:R282	8.44	No	No	5	7	8
183	R:R:R282	R:R:W352	23.99	No	Yes	5	8	8
184	R:R:F287	R:R:V283	5.24	No	No	0	3	4
185	R:R:T286	R:R:V340	4.76	No	No	0	7	5
186	R:R:F288	R:R:L289	4.87	No	No	0	7	7
187	R:R:L289	R:R:W339	9.11	No	Yes	5	7	8
188	R:R:I363	R:R:L289	8.56	No	No	5	7	7
189	R:R:F291	R:R:Y290	8.25	No	Yes	0	5	9
190	R:R:T294	R:R:Y290	8.74	No	Yes	0	8	9
191	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
192	R:R:V336	R:R:Y290	6.31	No	Yes	0	7	9
193	R:R:T294	R:R:W329	7.28	No	No	0	8	9
194	R:R:P332	R:R:T294	6.99	No	No	0	9	8
195	R:R:I299	R:R:N295	4.25	Yes	Yes	1	9	8
196	R:R:I367	R:R:Y296	8.46	No	Yes	0	7	7
197	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
198	R:R:Y296	R:R:Y421	14.89	Yes	Yes	1	7	8
199	R:R:F327	R:R:Y297	6.19	No	Yes	10	5	6
200	R:R:L331	R:R:Y297	4.69	No	Yes	10	4	6
201	R:R:F335	R:R:Y297	6.19	No	Yes	0	5	6
202	R:R:V301	R:R:W298	8.58	No	Yes	0	8	9
203	R:R:G328	R:R:W298	8.44	No	Yes	0	9	9
204	R:R:W298	R:R:W329	15.93	Yes	No	9	9	9
205	R:R:I299	R:R:N374	4.25	Yes	No	0	9	9
206	R:R:I299	R:R:Q451	5.49	Yes	Yes	1	9	9
207	R:R:L300	R:R:L304	6.92	Yes	No	0	8	5
208	R:R:L300	R:R:S370	4.5	Yes	No	0	8	7
209	R:R:L300	R:R:L373	6.92	Yes	No	0	8	7
210	R:R:L300	R:R:N374	6.87	Yes	No	0	8	9
211	R:R:F324	R:R:V301	9.18	No	No	0	7	8
212	R:R:E302	R:R:L416	11.93	Yes	No	0	9	9
213	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
214	R:R:L304	R:R:L377	4.15	No	No	0	5	7
215	R:R:L309	R:R:Y305	5.86	No	Yes	3	8	8
216	R:R:F315	R:R:Y305	6.19	Yes	Yes	3	6	8
217	R:R:E317	R:R:Y305	4.49	No	Yes	3	6	8
218	R:R:F324	R:R:Y305	4.13	No	Yes	0	7	8
219	R:R:I310	R:R:L306	4.28	No	No	0	8	9
220	R:R:F311	R:R:H307	18.1	No	No	0	6	8
221	R:R:H307	R:R:L377	11.57	No	No	0	8	7
222	R:R:H307	R:R:N380	6.38	No	No	0	8	8
223	R:R:F315	R:R:S308	7.93	Yes	No	0	6	7
224	R:R:F315	R:R:L309	4.87	Yes	No	3	6	8
225	R:R:F311	R:R:I310	7.54	No	No	0	6	8
226	R:R:I310	R:R:I381	4.42	No	No	0	8	9
227	R:R:E317	R:R:F315	8.16	No	Yes	3	6	6
228	R:R:F315	R:R:Y320	7.22	Yes	No	0	6	4
229	R:R:K319	R:R:S316	6.12	No	No	0	6	7
230	R:R:V326	R:R:W322	8.58	No	No	0	4	3
231	R:R:F327	R:R:L331	4.87	No	No	10	5	4
232	R:R:F335	R:R:P366	17.34	No	No	0	5	9
233	R:R:I363	R:R:V336	4.61	No	No	0	7	7
234	R:R:R343	R:R:W339	12	Yes	Yes	5	8	8
235	R:R:W339	R:R:W352	6.56	Yes	Yes	5	8	8
236	R:R:I363	R:R:W339	9.4	No	Yes	5	7	8
237	R:R:K359	R:R:V342	4.55	No	Yes	0	3	5
238	R:R:A347	R:R:R343	5.53	No	Yes	0	7	8
239	R:R:R343	R:R:W352	18.99	Yes	Yes	5	8	8
240	R:R:R343	R:R:S356	5.27	Yes	No	0	8	4
241	R:R:A347	R:R:K359	4.82	No	No	0	7	3
242	R:R:N348	R:R:W352	4.52	No	Yes	5	7	8
243	R:R:D353	R:R:L354	8.14	No	No	0	5	5
244	R:R:K360	R:R:S355	4.59	Yes	No	1	7	7
245	R:R:K359	R:R:S356	12.24	No	No	0	3	4
246	R:R:K360	R:R:W361	10.44	Yes	Yes	1	7	8
247	R:R:K360	R:R:Q364	5.42	Yes	Yes	1	7	7
248	R:R:K360	R:R:Y429	11.94	Yes	Yes	1	7	6
249	R:R:Q364	R:R:W361	7.67	Yes	Yes	1	7	8
250	R:R:V365	R:R:W361	4.9	No	Yes	0	5	8
251	R:R:Q364	R:R:Y429	6.76	Yes	Yes	1	7	6
252	R:R:I371	R:R:Y421	9.67	No	Yes	1	7	8
253	R:R:F417	R:R:N374	8.46	Yes	No	0	9	9
254	R:R:F375	R:R:I379	5.02	No	No	0	7	5
255	R:R:F375	R:R:I422	20.09	No	No	0	7	5
256	R:R:F378	R:R:V382	5.24	Yes	No	0	9	7
257	R:R:F378	R:R:M414	4.98	Yes	No	11	9	8
258	R:R:F378	R:R:F417	6.43	Yes	Yes	0	9	9
259	R:R:F378	R:R:V419	11.8	Yes	No	11	9	7
260	R:R:T410	R:R:V382	7.93	No	No	0	9	7
261	R:R:K388	R:R:V384	4.55	No	No	0	9	8
262	R:R:A386	R:R:L406	4.73	No	No	0	6	8
263	R:R:E391	R:R:T387	5.64	No	No	0	7	7
264	R:R:K405	R:R:L389	4.23	No	No	0	8	8
265	R:R:E391	R:R:R390	10.47	No	No	0	7	6
266	R:R:Q402	R:R:T399	18.43	No	No	0	6	6
267	R:R:Q401	R:R:R404	7.01	No	No	0	6	6
268	R:R:K405	R:R:R404	9.9	No	No	0	8	6
269	R:R:L407	R:R:L411	5.54	No	No	0	8	8
270	R:R:F417	R:R:L413	6.09	Yes	No	0	9	9
271	R:R:L413	R:R:Y459	4.69	No	Yes	0	9	8
272	R:R:M414	R:R:V419	7.61	No	No	11	8	7
273	R:R:F454	R:R:P415	5.78	No	No	0	6	9
274	R:R:I458	R:R:P415	5.08	No	No	0	8	9
275	R:R:L416	R:R:Y459	22.27	No	Yes	0	9	8
276	R:R:H420	R:R:Y421	19.6	Yes	Yes	1	8	8
277	R:R:F447	R:R:H420	6.79	No	Yes	0	5	8
278	R:R:H420	R:R:N448	6.38	Yes	No	1	8	6
279	R:R:H420	R:R:Q451	7.42	Yes	Yes	1	8	9
280	R:R:N448	R:R:Y421	17.44	No	Yes	1	6	8
281	R:R:Q451	R:R:Y421	10.15	Yes	Yes	1	9	8
282	R:R:I422	R:R:M425	4.37	No	No	0	5	6
283	R:R:F424	R:R:V423	9.18	Yes	No	1	7	6
284	R:R:V423	R:R:Y443	7.57	No	Yes	1	6	4
285	R:R:F424	R:R:T427	6.49	Yes	Yes	1	7	5
286	R:R:F424	R:R:Q440	8.2	Yes	Yes	1	7	6
287	R:R:F424	R:R:Y443	8.25	Yes	Yes	1	7	4
288	R:R:E444	R:R:F424	4.66	Yes	Yes	1	7	7
289	R:R:Q440	R:R:T427	12.76	Yes	Yes	1	6	5
290	R:R:E431	R:R:S433	8.62	No	No	0	3	3
291	R:R:V432	R:R:W437	17.16	No	Yes	1	5	5
292	R:R:M441	R:R:W437	16.29	Yes	Yes	1	6	5
293	R:R:M441	R:R:Q440	5.44	Yes	Yes	1	6	6
294	R:R:E444	R:R:Y443	4.49	Yes	Yes	1	7	4
295	R:R:F447	R:R:Y443	9.28	No	Yes	0	5	4
296	R:R:E444	R:R:N448	13.15	Yes	No	1	7	6
297	R:R:F447	R:R:L446	4.87	No	No	0	5	5
298	R:R:F450	R:R:S449	5.28	No	No	0	7	9
299	R:R:F453	R:R:I457	7.54	No	No	0	6	6
300	R:R:I458	R:R:Y459	7.25	No	Yes	0	8	8
301	R:R:C460	R:R:F461	5.59	No	No	0	9	8
302	R:R:N463	R:R:V466	8.87	Yes	No	0	9	9
303	R:R:E469	R:R:K472	12.15	Yes	No	0	9	7
304	R:R:T478	R:R:W474	7.28	No	No	0	4	5
305	L:L:R20	L:L:S17	3.95	Yes	No	0	0	0
306	L:L:H9	L:L:M8	3.94	Yes	No	0	0	0
307	R:R:E465	R:R:N463	3.94	No	Yes	0	9	9
308	R:R:F450	R:R:V197	3.93	No	No	0	7	5
309	R:R:F227	R:R:V206	3.93	Yes	No	0	9	5
310	R:R:F311	R:R:V384	3.93	No	No	0	6	8
311	R:R:F424	R:R:V439	3.93	Yes	No	0	7	5
312	R:R:S370	R:R:Y297	3.82	No	Yes	0	7	6
313	R:R:V126	R:R:Y145	3.79	No	Yes	0	4	4
314	R:R:F212	R:R:I470	3.77	Yes	No	0	7	5
315	R:R:F315	R:R:M312	3.73	Yes	No	0	6	5
316	R:R:G452	R:R:S198	3.71	No	No	0	9	9
317	R:R:H442	R:R:Q438	3.71	No	No	0	5	4
318	R:R:G194	R:R:V193	3.68	No	No	0	9	6
319	R:R:V340	R:R:W352	3.68	No	Yes	0	5	8
320	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
321	R:R:P119	R:R:V129	3.53	No	Yes	0	6	5
322	R:R:P130	R:R:V129	3.53	No	Yes	0	5	5
323	R:R:P158	R:R:V157	3.53	No	No	0	4	4
324	R:R:Q47	R:R:R51	3.5	No	No	0	6	6
325	R:R:P428	R:R:T427	3.5	No	Yes	0	7	5
326	R:R:N166	R:R:Y145	3.49	No	Yes	0	7	4
327	R:R:L481	R:R:W477	3.42	No	No	0	4	4
328	R:R:H216	R:R:R213	3.39	No	No	0	8	8
329	R:R:N358	R:R:W361	3.39	No	Yes	0	4	8
330	R:R:G464	R:R:N463	3.39	No	Yes	0	7	9
331	R:R:G418	R:R:Q451	3.29	No	Yes	0	9	9
332	R:R:L109	R:R:P110	3.28	No	No	0	5	6
333	R:R:A293	R:R:I367	3.25	No	No	0	6	7
334	R:R:S341	R:R:V342	3.23	No	Yes	0	5	5
335	R:R:C351	R:R:L244	3.17	No	Yes	0	9	5
336	R:R:A234	R:R:L199	3.15	No	No	0	8	7
337	R:R:A456	R:R:L202	3.15	No	No	0	8	9
338	R:R:F212	R:R:Y211	3.09	Yes	No	0	7	2
339	R:R:I362	R:R:V338	3.07	No	No	0	8	5
340	R:R:I458	R:R:V412	3.07	No	No	0	8	8
341	R:R:M425	R:R:V372	3.04	No	No	0	6	4
342	L:L:?35	R:R:R162	3.01	No	Yes	0	0	3
343	R:R:L385	R:R:S409	3	No	No	0	8	9
344	L:L:L28	R:R:V171	2.98	Yes	No	0	0	3
345	R:R:L199	R:R:V235	2.98	No	No	0	7	4
346	R:R:L331	R:R:V334	2.98	No	No	0	4	4
347	R:R:L346	R:R:V342	2.98	No	Yes	0	3	5
348	R:R:L199	R:R:T203	2.95	No	No	0	7	3
349	R:R:L346	R:R:T345	2.95	No	No	0	3	3
350	R:R:L436	R:R:T427	2.95	No	Yes	0	4	5
351	R:R:I190	R:R:M445	2.92	No	No	0	6	6
352	R:R:I381	R:R:L385	2.85	No	No	0	9	8
353	R:R:L411	R:R:M414	2.83	No	No	0	8	8
354	R:R:G323	R:R:W322	2.81	No	No	0	1	3
355	R:R:K172	R:R:N139	2.8	No	No	0	3	4
356	R:R:A165	R:R:R146	2.77	No	Yes	0	7	8
357	R:R:L389	R:R:L406	2.77	No	No	0	8	8
358	R:R:A128	R:R:Y145	2.67	No	Yes	0	5	4
359	R:R:H42	R:R:I38	2.65	No	No	0	4	7
360	R:R:F461	R:R:V204	2.62	No	No	0	8	5
361	R:R:F375	R:R:V419	2.62	No	No	0	7	7
362	R:R:A44	R:R:W112	2.59	No	No	0	7	7
363	R:R:A344	R:R:W352	2.59	No	Yes	0	4	8
364	L:L:H14	L:L:L15	2.57	Yes	No	0	0	0
365	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
366	R:R:F461	R:R:I208	2.51	No	No	0	8	8
367	R:R:I379	R:R:R383	2.51	No	No	0	5	8
368	R:R:T399	R:R:Y403	2.5	No	No	0	6	7
369	R:R:L40	R:R:R43	2.43	No	No	0	5	4
370	R:R:G330	R:R:P332	2.03	No	No	0	7	9
371	R:R:G357	R:R:S355	1.86	No	No	0	6	7
372	L:L:G12	R:R:L354	1.71	No	No	0	0	5
373	R:R:C281	R:R:V243	1.71	No	No	0	9	5
374	R:R:A284	R:R:V239	1.7	No	No	0	6	5
375	R:R:L120	R:R:P110	1.64	No	No	0	4	6
376	R:R:E431	R:R:G434	1.64	No	No	0	3	5
377	R:R:C462	R:R:I457	1.64	No	No	0	6	6
378	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
379	R:R:A46	R:R:K50	1.61	No	No	0	5	4
380	R:R:A210	R:R:M224	1.61	No	No	0	4	5
381	R:R:A426	R:R:M425	1.61	No	No	0	5	6
382	R:R:A468	R:R:K472	1.61	No	No	0	5	7
383	R:R:V338	R:R:V342	1.6	No	Yes	0	5	5
384	R:R:T435	R:R:V439	1.59	No	No	0	1	5
385	R:R:I376	R:R:V372	1.54	No	No	0	4	4
386	R:R:K408	R:R:V412	1.52	No	No	0	8	8
387	R:R:G350	R:R:R282	1.5	No	No	0	5	8
388	L:L:V2	R:R:L368	1.49	Yes	No	0	0	4
389	R:R:L156	R:R:T163	1.47	No	No	0	4	5
390	R:R:L406	R:R:T410	1.47	No	No	0	8	9
391	R:R:E180	R:R:S433	1.44	No	No	0	3	3
392	R:R:I222	R:R:L321	1.43	No	No	0	9	6
393	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
394	R:R:E35	R:R:T33	1.41	No	No	0	5	7
395	R:R:A313	R:R:F314	1.39	No	No	0	7	7
396	L:L:D30	L:L:K27	1.38	No	No	0	0	0
397	L:L:E19	R:R:K34	1.35	No	No	0	0	4
398	L:L:D30	L:L:N33	1.35	No	No	0	0	0
399	R:R:C281	R:R:Y278	1.34	No	No	0	9	4
400	R:R:L40	R:R:Q37	1.33	No	Yes	0	5	7
401	R:R:R476	R:R:S475	1.32	No	No	0	7	4
402	L:L:D30	L:L:Q29	1.31	No	No	0	0	0
403	R:R:F238	R:R:T192	1.3	No	No	0	7	7
404	R:R:R343	R:R:T349	1.29	Yes	No	0	8	5
405	R:R:D133	R:R:H140	1.26	No	No	0	2	3
406	R:R:K472	R:R:R476	1.24	No	No	0	7	7
407	L:L:R25	R:R:N176	1.21	No	No	0	0	3
408	R:R:T478	R:R:W477	1.21	No	No	0	4	4
409	R:R:K319	R:R:Y320	1.19	No	No	0	6	4
410	R:R:Q401	R:R:R400	1.17	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:V2	6.0025	4	1	0
2	L:L:Q6	9.53	5	1	0
3	L:L:H9	5.802	5	1	0
4	L:L:H14	6.9425	4	0	0
5	L:L:R20	12.44	4	4	0
6	L:L:W23	6.8925	4	4	0
7	L:L:L28	5.13	4	2	0
8	R:R:Q37	5.762	5	4	7
9	R:R:E111	8.75	4	2	7
10	R:R:L116	7.82	4	2	5
11	R:R:W118	13.81	5	2	9
12	R:R:V129	5.4	4	2	5
13	R:R:P132	8.7175	4	2	9
14	R:R:Y134	8.02	4	2	5
15	R:R:I135	8.26	4	2	7
16	R:R:F138	9.32333	6	2	4
17	R:R:Y145	4.17	4	0	4
18	R:R:R146	14.908	5	2	8
19	R:R:W154	12.36	4	2	9
20	R:R:R162	12.1	4	6	3
21	R:R:Y167	5.43571	7	2	5
22	R:R:L187	6.0825	4	1	5
23	R:R:Y191	5.63	4	7	7
24	R:R:Y195	8.038	5	0	7
25	R:R:F212	6.17667	6	8	7
26	R:R:R219	6.922	5	3	9
27	R:R:L226	8.4775	4	0	9
28	R:R:F227	5.136	5	0	9
29	R:R:F230	8.51429	7	1	8
30	R:R:R233	11.01	5	1	8
31	R:R:L244	7.47	5	0	5
32	R:R:Y290	7.16	4	0	9
33	R:R:N295	11.07	4	1	8
34	R:R:Y296	10.6475	4	1	7
35	R:R:Y297	5.2225	4	10	6
36	R:R:W298	11.034	5	9	9
37	R:R:I299	5.0675	4	1	9
38	R:R:L300	6.3025	4	0	8
39	R:R:E302	11.735	4	0	9
40	R:R:Y305	5.46286	7	3	8
41	R:R:F315	6.35	6	3	6
42	R:R:W339	9.2675	4	5	8
43	R:R:V342	3.09	4	0	5
44	R:R:R343	8.616	5	5	8
45	R:R:W352	10.055	6	5	8
46	R:R:K360	7.526	5	1	7
47	R:R:W361	6.6	4	1	8
48	R:R:Q364	6.774	5	1	7
49	R:R:F378	7.1125	4	11	9
50	R:R:F417	6.75	4	0	9
51	R:R:H420	10.0475	4	1	8
52	R:R:Y421	12.645	6	1	8
53	R:R:F424	6.785	6	1	7
54	R:R:T427	6.425	4	1	5
55	R:R:Y429	12.78	4	1	6
56	R:R:W437	9.75	5	1	5
57	R:R:Q440	7.17	5	1	6
58	R:R:M441	7.17	6	1	6
59	R:R:Y443	7.3975	4	1	4
60	R:R:E444	8.45	4	1	7
61	R:R:Q451	7.378	5	1	9
62	R:R:Y459	9.6425	4	0	8
63	R:R:N463	5.8575	4	0	9
64	R:R:E469	11.64	4	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q6	R:R:Y429	12.0475	24.8	Yes	Yes	1	0	6
2	L:L:V2	R:R:I367	12.1672	4.61	Yes	No	0	0	7
3	L:L:S3	R:R:M441	11.6936	4.6	No	Yes	1	0	6
4	L:L:S3	R:R:E444	14.0091	11.5	No	Yes	1	0	7
5	R:R:M441	R:R:W437	21.0027	16.29	Yes	Yes	1	6	5
6	L:L:L11	R:R:F184	22.7368	8.53	No	No	0	0	6
7	R:R:F184	R:R:W437	24.8096	6.01	No	Yes	0	6	5
8	L:L:L11	R:R:Y245	22.8531	12.89	No	No	0	0	4
9	L:L:N16	R:R:L354	98.7968	4.12	No	No	0	0	5
10	R:R:D353	R:R:L354	99.6023	8.14	No	No	0	5	5
11	R:R:D353	R:R:L244	100	14.93	No	Yes	0	5	5
12	R:R:L244	R:R:Y245	23.4867	10.55	Yes	No	0	5	4
13	L:L:N16	R:R:T33	98.3889	4.39	No	No	0	0	7
14	R:R:E36	R:R:T33	97.5632	16.93	No	No	0	6	7
15	R:R:E36	R:R:M32	97.1453	6.77	No	No	0	6	6
16	R:R:M32	R:R:Q37	93.3873	8.16	No	Yes	4	6	7
17	L:L:W23	R:R:Q37	90.5022	4.38	Yes	Yes	4	0	7
18	L:L:W23	R:R:L41	88.1749	6.83	Yes	No	0	0	8
19	L:L:V31	R:R:Y167	60.9269	6.31	No	Yes	2	0	5
20	L:L:V31	R:R:I115	85.2663	4.61	No	No	0	0	5
21	L:L:K27	R:R:I115	85.7668	4.36	No	No	0	0	5
22	L:L:K27	R:R:L41	87.7014	5.64	No	No	0	0	8
23	R:R:F138	R:R:Y167	15.846	4.13	Yes	Yes	2	4	5
24	L:L:V31	R:R:D113	23.8338	7.3	No	No	2	0	9
25	L:L:?35	L:L:F34	10.4146	9.04	No	No	0	0	0
26	L:L:F34	R:R:E111	13.3519	9.33	No	Yes	0	0	7
27	R:R:E111	R:R:R146	14.7186	11.63	Yes	Yes	2	7	8
28	R:R:R146	R:R:W118	26.4425	40.98	Yes	Yes	2	8	9
29	R:R:D113	R:R:W118	23.2053	6.7	No	Yes	2	9	9
30	R:R:W118	R:R:Y167	23.8153	4.82	Yes	Yes	2	9	5
31	R:R:L116	R:R:Y167	17.1621	5.86	Yes	Yes	2	5	5
32	R:R:P132	R:R:Y134	11.8891	12.52	Yes	Yes	2	9	5
33	R:R:A44	R:R:Y134	11.1122	6.67	No	Yes	0	7	5
34	R:R:V129	R:R:W118	20.3825	8.58	Yes	Yes	2	5	9
35	R:R:L116	R:R:V129	10.4735	5.96	Yes	Yes	2	5	5
36	R:R:P130	R:R:V129	26.4897	3.53	No	Yes	0	5	5
37	R:R:H143	R:R:P130	24.3006	9.15	No	No	0	3	5
38	R:R:G142	R:R:H143	22.1082	4.77	No	No	0	5	3
39	R:R:E169	R:R:G142	19.9124	4.91	No	No	0	5	5
40	R:R:E169	R:R:Y145	17.7132	6.73	No	Yes	0	5	4
41	R:R:I237	R:R:Y195	80.6539	6.04	No	Yes	0	7	7
42	R:R:D241	R:R:I237	78.3721	4.2	No	No	7	8	7
43	R:R:I367	R:R:Y296	14.0917	8.46	No	Yes	0	7	7
44	R:R:R233	R:R:Y296	10.8426	14.4	Yes	Yes	1	8	7
45	R:R:E444	R:R:N448	19.9612	13.15	Yes	No	1	7	6
46	R:R:N448	R:R:Y421	11.5656	17.44	No	Yes	1	6	8
47	R:R:R233	R:R:Y195	85.1432	12.35	Yes	Yes	0	8	7
48	R:R:H420	R:R:Q451	13.2642	7.42	Yes	Yes	1	8	9
49	R:R:F230	R:R:Q451	16.6919	10.54	Yes	Yes	1	8	9
50	R:R:F230	R:R:L202	13.4732	6.09	Yes	No	0	8	9
51	R:R:F227	R:R:L202	12.0138	8.53	Yes	No	0	9	9
52	R:R:Q451	R:R:Y421	14.7809	10.15	Yes	Yes	1	9	8
53	R:R:F230	R:R:L226	37.1419	7.31	Yes	Yes	0	8	9
54	R:R:F227	R:R:L226	20.7718	4.87	Yes	Yes	0	9	9
55	R:R:E302	R:R:L226	41.8504	17.23	Yes	Yes	0	9	9
56	R:R:E302	R:R:H223	18.9198	12.31	Yes	No	0	9	9
57	R:R:H223	R:R:R219	14.422	5.64	No	Yes	0	9	9
58	R:R:C460	R:R:F227	25.0961	4.19	No	Yes	0	9	9
59	R:R:C460	R:R:F461	23.3199	5.59	No	No	0	9	8
60	R:R:F461	R:R:I208	19.791	2.51	No	No	0	8	8
61	R:R:F212	R:R:I208	18.0839	2.51	Yes	No	0	7	8
62	R:R:E302	R:R:I222	15.7415	5.47	Yes	No	0	9	9
63	R:R:I222	R:R:Y305	10.5089	8.46	No	Yes	0	9	8
64	R:R:I299	R:R:Q451	10.8713	5.49	Yes	Yes	1	9	9
65	R:R:I299	R:R:N374	40.1264	4.25	Yes	No	0	9	9
66	R:R:F417	R:R:N374	25.519	8.46	Yes	No	0	9	9
67	R:R:N295	R:R:R233	86.0516	14.46	Yes	Yes	1	8	8
68	R:R:N295	R:R:S229	35.5831	7.45	Yes	No	0	8	9
69	R:R:S229	R:R:W298	16.242	7.41	No	Yes	0	9	9
70	R:R:W298	R:R:W329	11.0246	15.93	Yes	No	9	9	9
71	R:R:K240	R:R:L244	86.9363	4.23	No	Yes	0	7	5
72	R:R:F288	R:R:K240	20.1719	19.85	No	No	0	7	7
73	R:R:F288	R:R:L289	19.5012	4.87	No	No	0	7	7
74	R:R:I363	R:R:V336	11.0954	4.61	No	No	0	7	7
75	R:R:V336	R:R:Y290	11.0398	6.31	No	Yes	0	7	9
76	R:R:T294	R:R:W329	11.579	7.28	No	No	0	8	9
77	R:R:T294	R:R:Y290	11.301	8.74	No	Yes	0	8	9
78	R:R:L289	R:R:W339	14.7203	9.11	No	Yes	5	7	8
79	R:R:L300	R:R:N374	18.5069	6.87	Yes	No	0	8	9
80	R:R:L300	R:R:L304	10.7567	6.92	Yes	No	0	8	5
81	R:R:R343	R:R:W339	15.0135	12	Yes	Yes	5	8	8
82	R:R:K359	R:R:V342	10.2208	4.55	No	Yes	0	3	5
83	R:R:F378	R:R:F417	21.0212	6.43	Yes	Yes	0	9	9
84	R:R:F378	R:R:V382	10.3522	5.24	Yes	No	0	9	7
85	R:R:I458	R:R:Y459	13.7395	7.25	No	Yes	0	8	8
86	R:R:D241	R:R:K240	79.6849	5.53	No	No	0	8	7
87	R:R:L226	R:R:S229	26.3718	4.5	Yes	No	0	9	9
88	R:R:F230	R:R:N295	32.5632	18.12	Yes	Yes	1	8	8
89	R:R:I299	R:R:N295	27.0138	4.25	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Q364	7.16	1	Yes	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	1	Yes	No	0	7	0	1
L:L:S3	R:R:Q440	4.33	1	No	Yes	0	6	0	1
L:L:S3	R:R:M441	4.6	1	No	Yes	0	6	0	1
L:L:S3	R:R:E444	11.5	1	No	Yes	0	7	0	1
L:L:E4	R:R:Y195	10.1	0	No	Yes	0	7	0	1
L:L:E4	R:R:M445	8.12	0	No	No	0	6	0	1
L:L:I5	R:R:Q364	6.86	1	No	Yes	0	7	0	1
L:L:Q6	R:R:Y429	24.8	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:Q440	5.12	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:L187	4.15	1	No	Yes	0	5	0	1
L:L:L7	R:R:M441	4.24	1	No	Yes	0	6	0	1
L:L:H9	R:R:S355	5.58	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	5.24	1	Yes	Yes	0	7	0	1
L:L:H9	R:R:Y429	7.62	1	Yes	Yes	0	6	0	1
L:L:N10	R:R:V432	4.43	1	No	No	0	5	0	1
L:L:N10	R:R:W437	5.65	1	No	Yes	0	5	0	1
L:L:L11	R:R:F184	8.53	0	No	No	0	6	0	1
L:L:L11	R:R:Y245	12.89	0	No	No	0	4	0	1
L:L:H14	R:R:R181	6.77	0	Yes	No	0	3	0	1
L:L:H14	R:R:F184	7.92	0	Yes	No	0	6	0	1
L:L:N16	R:R:T33	4.39	0	No	No	0	7	0	1
L:L:N16	R:R:L354	4.12	0	No	No	0	5	0	1
L:L:R20	R:R:Q37	8.18	4	Yes	Yes	0	7	0	1
L:L:R20	R:R:Y136	25.72	4	Yes	No	0	4	0	1
L:L:R20	R:R:D137	11.91	4	Yes	No	0	5	0	1
L:L:V21	R:R:D137	5.84	0	No	No	0	5	0	1
L:L:W23	R:R:K34	6.96	4	Yes	No	0	4	0	1
L:L:W23	R:R:Q37	4.38	4	Yes	Yes	0	7	0	1
L:L:W23	R:R:I38	9.4	4	Yes	No	0	7	0	1
L:L:W23	R:R:L41	6.83	4	Yes	No	0	8	0	1
L:L:L24	R:R:I135	4.28	2	No	Yes	0	7	0	1
L:L:L24	R:R:F138	7.31	2	No	Yes	0	4	0	1
L:L:R25	R:R:L174	7.29	0	No	No	0	3	0	1
L:L:K27	R:R:L41	5.64	0	No	No	0	8	0	1
L:L:K27	R:R:I115	4.36	0	No	No	0	5	0	1
L:L:L28	R:R:F138	7.31	2	Yes	Yes	0	4	0	1
L:L:L28	R:R:Y167	4.69	2	Yes	Yes	0	5	0	1
L:L:V31	R:R:D113	7.3	2	No	No	0	9	0	1
L:L:V31	R:R:I115	4.61	2	No	No	0	5	0	1
L:L:V31	R:R:Y167	6.31	2	No	Yes	0	5	0	1
L:L:H32	R:R:R162	5.64	0	No	Yes	0	3	0	1
L:L:F34	R:R:E111	9.33	0	No	Yes	0	7	0	1
L:L:F34	R:R:H114	6.79	0	No	No	0	4	0	1
R:R:E36	R:R:M32	6.77	0	No	No	6	6	2	2
R:R:M32	R:R:Q37	8.16	4	No	Yes	6	7	2	1
R:R:M32	R:R:Y136	4.79	4	No	No	6	4	2	1
R:R:E36	R:R:T33	16.93	0	No	No	6	7	2	1
R:R:I38	R:R:K34	4.36	4	No	No	7	4	1	1
R:R:Q37	R:R:Y136	6.76	4	Yes	No	7	4	1	1
R:R:E111	R:R:R146	11.63	2	Yes	Yes	7	8	1	2
R:R:E111	R:R:W154	9.81	2	Yes	Yes	7	9	1	2
R:R:E111	R:R:T163	4.23	2	Yes	No	7	5	1	2
R:R:D113	R:R:W118	6.7	2	No	Yes	9	9	1	2
R:R:D113	R:R:Y167	6.9	2	No	Yes	9	5	1	1
R:R:L116	R:R:W118	7.97	2	Yes	Yes	5	9	2	2
R:R:L116	R:R:P132	11.49	2	Yes	Yes	5	9	2	2
R:R:L116	R:R:Y167	5.86	2	Yes	Yes	5	5	2	1
R:R:R146	R:R:W118	40.98	2	Yes	Yes	8	9	2	2
R:R:W118	R:R:Y167	4.82	2	Yes	Yes	9	5	2	1
R:R:P132	R:R:Y134	12.52	2	Yes	Yes	9	5	2	2
R:R:I135	R:R:P132	5.08	2	Yes	Yes	7	9	1	2
R:R:F138	R:R:P132	5.78	2	Yes	Yes	4	9	1	2
R:R:I135	R:R:Y134	4.84	2	Yes	Yes	7	5	1	2
R:R:F138	R:R:I135	18.84	2	Yes	Yes	4	7	1	1
R:R:F138	R:R:Y167	4.13	2	Yes	Yes	4	5	1	1
R:R:C170	R:R:F138	12.57	0	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	5.34	0	No	Yes	7	5	2	1
R:R:R146	R:R:W154	13.99	2	Yes	Yes	8	9	2	2
R:R:R146	R:R:T163	5.17	2	Yes	No	8	5	2	2
R:R:H160	R:R:V157	9.69	6	No	No	4	4	2	2
R:R:R162	R:R:V157	18.31	6	Yes	No	3	4	1	2
R:R:H160	R:R:R162	21.44	6	No	Yes	4	3	2	1
R:R:L174	R:R:V171	4.47	0	No	No	3	3	1	1
R:R:E180	R:R:V432	14.26	0	No	No	3	5	2	1
R:R:D185	R:R:R181	8.34	0	No	No	2	3	2	1
R:R:F184	R:R:W437	6.01	0	No	Yes	6	5	1	1
R:R:L187	R:R:M441	5.65	1	Yes	Yes	5	6	1	1
R:R:H442	R:R:L187	10.29	0	No	Yes	5	5	2	1
R:R:L187	R:R:M445	4.24	1	Yes	No	5	6	1	1
R:R:R233	R:R:Y195	12.35	1	Yes	Yes	8	7	2	1
R:R:A234	R:R:Y195	5.34	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	6.04	7	No	Yes	7	7	2	1
R:R:S449	R:R:Y195	6.36	0	No	Yes	9	7	2	1
R:R:R233	R:R:Y296	14.4	1	Yes	Yes	8	7	2	2
R:R:L244	R:R:Y245	10.55	0	Yes	No	5	4	2	1
R:R:D353	R:R:L244	14.93	0	No	Yes	5	5	2	2
R:R:I367	R:R:Y296	8.46	0	No	Yes	7	7	1	2
R:R:D353	R:R:L354	8.14	0	No	No	5	5	2	1
R:R:K360	R:R:S355	4.59	1	Yes	No	7	7	1	1
R:R:K360	R:R:W361	10.44	1	Yes	Yes	7	8	1	2
R:R:K360	R:R:Q364	5.42	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	11.94	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	7.67	1	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	6.76	1	Yes	Yes	7	6	1	1
R:R:F424	R:R:T427	6.49	1	Yes	Yes	7	5	2	2
R:R:F424	R:R:Q440	8.2	1	Yes	Yes	7	6	2	1
R:R:F424	R:R:Y443	8.25	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	4.66	1	Yes	Yes	7	7	1	2
R:R:Q440	R:R:T427	12.76	1	Yes	Yes	6	5	1	2
R:R:V432	R:R:W437	17.16	1	No	Yes	5	5	1	1
R:R:M441	R:R:W437	16.29	1	Yes	Yes	6	5	1	1
R:R:M441	R:R:Q440	5.44	1	Yes	Yes	6	6	1	1
R:R:E444	R:R:Y443	4.49	1	Yes	Yes	7	4	1	2
R:R:E444	R:R:N448	13.15	1	Yes	No	7	6	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:A293	R:R:I367	3.25	0	No	No	6	7	2	1
L:L:?35	R:R:R162	3.01	0	No	Yes	0	3	0	1
L:L:L28	R:R:V171	2.98	2	Yes	No	0	3	0	1
R:R:I190	R:R:M445	2.92	0	No	No	6	6	2	1
R:R:H42	R:R:I38	2.65	0	No	No	4	7	2	1
R:R:G357	R:R:S355	1.86	0	No	No	6	7	2	1
L:L:G12	R:R:L354	1.71	0	No	No	0	5	0	1
L:L:V2	R:R:L368	1.49	1	Yes	No	0	4	0	1
R:R:E35	R:R:T33	1.41	0	No	No	5	7	2	1
L:L:E19	R:R:K34	1.35	0	No	No	0	4	0	1
R:R:L40	R:R:Q37	1.33	0	No	Yes	5	7	2	1
L:L:R25	R:R:N176	1.21	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JR2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.11
Number of Linked Nodes	358
Number of Links	410
Number of Hubs	64
Number of Links mediated by Hubs	232
Number of Communities	11
Number of Nodes involved in Communities	88
Number of Links involved in Communities	127

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	123035
Length Of Smallest Path	3
Average Path Length	19.4957
Length of Longest Path	43
Minimum Path Strength	1.28
Average Path Strength	7.99392
Maximum Path Strength	27.485
Minimum Path Correlation	0.7
Average Path Correlation	0.963531
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	60.1329
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9513
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • parathyroid hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • type 1 parathyroid hormone receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • hormone activity • response to xenobiotic stimulus • response to parathyroid hormone • magnesium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • monoatomic cation homeostasis • ossification • bone mineralization • biomineral tissue development • tissue development • multicellular organismal-level homeostasis • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • biosynthetic process • metabolic process • macromolecule metabolic process • macromolecule biosynthetic process • skeletal system development • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • negative regulation of apoptotic process in bone marrow cell • negative regulation of programmed cell death • apoptotic process in bone marrow cell • regulation of apoptotic process in bone marrow cell • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • negative regulation of apoptotic process • negative regulation of cellular process • regulation of generation of precursor metabolites and energy • regulation of primary metabolic process • positive regulation of glycogen metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • carbohydrate biosynthetic process • hexose metabolic process • positive regulation of glucose metabolic process • positive regulation of glycogen biosynthetic process • energy reserve metabolic process • positive regulation of carbohydrate metabolic process • regulation of glycogen metabolic process • monosaccharide metabolic process • regulation of glycogen biosynthetic process • glucan biosynthetic process • energy derivation by oxidation of organic compounds • regulation of glucan biosynthetic process • regulation of polysaccharide metabolic process • polysaccharide metabolic process • glucan metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • carbohydrate metabolic process • polysaccharide biosynthetic process • glycogen metabolic process • generation of precursor metabolites and energy • glycogen biosynthetic process • regulation of polysaccharide biosynthetic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • glucose metabolic process • phosphate ion homeostasis • cell-cell signaling • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • response to ethanol • response to metal ion • response to lead ion • positive regulation of cell population proliferation • positive regulation of cell proliferation in bone marrow • cell proliferation in bone marrow • regulation of cell proliferation in bone marrow • regulation of cell population proliferation • response to nutrient levels • response to vitamin D • response to nutrient • response to vitamin • hormone-mediated signaling pathway • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • regulation of cartilage development • regulation of chondrocyte differentiation • connective tissue development • cellular developmental process • negative regulation of cartilage development • negative regulation of chondrocyte differentiation • regulation of cell differentiation • cell differentiation • negative regulation of cell differentiation • negative regulation of developmental process • chondrocyte differentiation • negative regulation of multicellular organismal process • cartilage development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • regulation of localization • hexose transmembrane transport • D-glucose import • transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • localization • positive regulation of transmembrane transport • regulation of D-glucose import • positive regulation of D-glucose import • regulation of transport • establishment of localization • transmembrane transport • regulation of transmembrane transport • positive regulation of transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • response to cadmium ion • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • regulation of leukocyte proliferation • osteoclast proliferation • regulation of osteoclast proliferation • positive regulation of osteoclast proliferation • leukocyte proliferation • positive regulation of leukocyte proliferation • bone maturation • regulation of bone mineralization involved in bone maturation • negative regulation of biomineral tissue development • negative regulation of bone mineralization • ossification involved in bone maturation • bone development • bone mineralization involved in bone maturation • developmental maturation • negative regulation of bone mineralization involved in bone maturation • negative regulation of ossification • anatomical structure maturation • animal organ maturation • positive regulation of DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • polyol biosynthetic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of alcohol biosynthetic process • tissue remodeling • bone remodeling • bone resorption • response to fibroblast growth factor • response to growth factor • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • osteoblast development • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • cell maturation • cell surface receptor signaling pathway • negative regulation of cell population proliferation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?35
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>9JR2_nogp_Chain_R M T K E E Q I F L L H R A Q A Q C E K R L K E C L P E W D H I L C W P L V V A V P C P D Y I Y D F N H K G H A Y R R C W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L D F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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Download 9JR2_nogp.zip

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