psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I5	L:L:V2	10.75	Yes	Yes	1	0	0
2	L:L:V2	R:R:Y296	3.79	Yes	Yes	1	0	7
3	L:L:V2	R:R:Q364	8.6	Yes	Yes	1	0	7
4	L:L:V2	R:R:I367	4.61	Yes	No	1	0	7
5	L:L:A3	R:R:E444	6.03	No	Yes	0	0	7
6	L:L:E4	R:R:Y195	12.35	Yes	Yes	1	0	7
7	L:L:E4	R:R:R233	4.65	Yes	Yes	1	0	8
8	L:L:E4	R:R:I237	4.1	Yes	Yes	1	0	7
9	L:L:E4	R:R:M445	9.47	Yes	Yes	1	0	6
10	L:L:H9	L:L:I5	6.63	Yes	Yes	1	0	0
11	L:L:I5	R:R:L289	5.71	Yes	Yes	1	0	7
12	L:L:I5	R:R:L292	4.28	Yes	No	1	0	6
13	L:L:I5	R:R:Q364	12.35	Yes	Yes	1	0	7
14	L:L:Q10	L:L:Q6	7.68	Yes	Yes	1	0	0
15	L:L:Q6	R:R:Y429	29.31	Yes	Yes	1	0	6
16	L:L:Q6	R:R:M441	5.44	Yes	Yes	1	0	6
17	L:L:L7	R:R:L187	4.15	No	Yes	1	0	5
18	L:L:L7	R:R:M441	5.65	No	Yes	1	0	6
19	L:L:L7	R:R:M445	5.65	No	Yes	1	0	6
20	L:L:H9	L:L:M8	5.25	Yes	Yes	1	0	0
21	L:L:M8	R:R:K240	11.52	Yes	No	1	0	7
22	L:L:M8	R:R:F288	6.22	Yes	Yes	1	0	7
23	L:L:M8	R:R:D353	8.32	Yes	Yes	1	0	5
24	L:L:H9	R:R:S355	8.37	Yes	No	0	0	7
25	L:L:H9	R:R:K360	7.86	Yes	No	1	0	7
26	L:L:H9	R:R:Y429	14.16	Yes	Yes	1	0	6
27	L:L:Q10	R:R:Y429	4.51	Yes	Yes	1	0	6
28	L:L:Q10	R:R:V432	5.73	Yes	Yes	1	0	5
29	L:L:Q10	R:R:W437	6.57	Yes	Yes	1	0	5
30	L:L:R11	L:L:W14	4	No	Yes	1	0	0
31	L:L:R11	R:R:F184	17.1	No	Yes	1	0	6
32	L:L:R11	R:R:Y245	20.58	No	Yes	1	0	4
33	L:L:A12	R:R:D353	6.18	No	Yes	0	0	5
34	L:L:I15	L:L:W14	5.87	No	Yes	0	0	0
35	L:L:A18	L:L:W14	5.19	No	Yes	0	0	0
36	L:L:W14	R:R:R181	4	Yes	No	0	0	3
37	L:L:W14	R:R:F184	12.03	Yes	Yes	1	0	6
38	L:L:Q16	R:R:V31	8.6	No	Yes	8	0	6
39	L:L:Q16	R:R:T33	4.25	No	No	0	0	7
40	L:L:Q16	R:R:L354	6.65	No	No	8	0	5
41	L:L:D17	L:L:R20	17.87	No	Yes	0	0	0
42	L:L:D17	R:R:V31	4.38	No	Yes	0	0	6
43	L:L:R20	R:R:Y136	11.32	Yes	No	0	0	4
44	L:L:R20	R:R:D137	10.72	Yes	Yes	0	0	5
45	L:L:R21	R:R:D137	13.1	No	Yes	0	0	5
46	L:L:F23	L:L:L27	10.96	No	No	0	0	0
47	L:L:F23	R:R:K34	22.33	No	No	9	0	4
48	L:L:F23	R:R:I38	5.02	No	No	9	0	7
49	L:L:L24	R:R:D137	4.07	No	Yes	0	0	5
50	L:L:L24	R:R:F138	9.74	No	Yes	0	0	4
51	L:L:H25	R:R:L174	3.86	No	No	0	0	3
52	L:L:E30	L:L:K26	9.45	No	No	0	0	0
53	L:L:I31	R:R:I115	5.89	No	No	0	0	5
54	L:L:H32	R:R:N166	3.83	No	No	0	0	7
55	L:L:H32	R:R:Y167	7.62	No	Yes	0	0	5
56	R:R:L354	R:R:V31	4.47	No	Yes	8	5	6
57	R:R:M32	R:R:Q37	4.08	No	Yes	0	6	7
58	R:R:M32	R:R:Y136	8.38	No	No	0	6	4
59	R:R:E36	R:R:T33	11.29	No	No	0	6	7
60	R:R:I38	R:R:K34	4.36	No	No	9	7	4
61	R:R:E35	R:R:E36	3.81	No	No	0	5	6
62	R:R:L40	R:R:Q37	5.32	No	Yes	0	5	7
63	R:R:Q37	R:R:Y134	4.51	Yes	Yes	4	7	5
64	R:R:I135	R:R:Q37	5.49	Yes	Yes	4	7	7
65	R:R:F39	R:R:R43	4.28	No	No	0	7	4
66	R:R:L41	R:R:Y134	4.69	No	Yes	0	8	5
67	R:R:A46	R:R:R43	4.15	No	No	0	5	4
68	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
69	R:R:Q45	R:R:W112	23	No	Yes	0	7	7
70	R:R:C48	R:R:W112	11.75	No	Yes	0	8	7
71	R:R:C117	R:R:C48	7.28	No	No	0	9	8
72	R:R:E54	R:R:K53	4.05	No	No	0	6	5
73	R:R:G105	R:R:P123	4.06	No	No	0	5	7
74	R:R:P107	R:R:P123	5.84	No	No	0	3	7
75	R:R:C108	R:R:C148	7.28	No	No	0	9	9
76	R:R:C108	R:R:W154	18.28	No	Yes	0	9	9
77	R:R:L109	R:R:P110	4.93	No	No	0	5	6
78	R:R:E111	R:R:W154	4.36	No	Yes	0	7	9
79	R:R:H114	R:R:W112	4.23	No	Yes	0	4	7
80	R:R:D113	R:R:W118	11.17	No	Yes	6	9	9
81	R:R:D113	R:R:R146	7.15	No	Yes	6	9	8
82	R:R:D113	R:R:Y167	8.05	No	Yes	6	9	5
83	R:R:I115	R:R:L116	4.28	No	No	0	5	5
84	R:R:I115	R:R:Y167	16.92	No	Yes	0	5	5
85	R:R:L116	R:R:P132	9.85	No	Yes	0	5	9
86	R:R:V129	R:R:W118	6.13	No	Yes	0	5	9
87	R:R:R146	R:R:W118	19.99	Yes	Yes	6	8	9
88	R:R:W118	R:R:Y167	3.86	Yes	Yes	6	9	5
89	R:R:C148	R:R:G121	3.92	No	No	0	9	7
90	R:R:G121	R:R:W154	4.22	No	Yes	0	7	9
91	R:R:V126	R:R:Y145	20.19	No	Yes	10	4	4
92	R:R:R147	R:R:V126	3.92	No	No	10	3	4
93	R:R:C131	R:R:C170	7.28	No	No	0	9	9
94	R:R:P132	R:R:Y134	6.95	Yes	Yes	4	9	5
95	R:R:I135	R:R:P132	5.08	Yes	Yes	4	7	9
96	R:R:F138	R:R:P132	5.78	Yes	Yes	4	4	9
97	R:R:I135	R:R:Y134	10.88	Yes	Yes	4	7	5
98	R:R:F138	R:R:I135	17.58	Yes	Yes	4	4	7
99	R:R:C170	R:R:F138	11.17	No	Yes	0	9	4
100	R:R:K141	R:R:N139	9.79	No	No	0	3	4
101	R:R:F173	R:R:N139	10.87	No	No	0	3	4
102	R:R:G142	R:R:H143	4.77	No	No	0	5	3
103	R:R:E169	R:R:H143	8.62	No	No	0	5	3
104	R:R:A144	R:R:Y167	4	No	Yes	0	7	5
105	R:R:R147	R:R:Y145	5.14	No	Yes	10	3	4
106	R:R:W164	R:R:Y145	23.15	No	Yes	0	5	4
107	R:R:N166	R:R:Y145	5.81	No	Yes	0	7	4
108	R:R:R146	R:R:W154	8	Yes	Yes	0	8	9
109	R:R:R146	R:R:T163	15.52	Yes	No	0	8	5
110	R:R:E155	R:R:R147	6.98	No	No	0	4	3
111	R:R:D149	R:R:N151	4.04	No	No	0	5	5
112	R:R:D149	R:R:E155	5.2	No	No	0	5	4
113	R:R:G152	R:R:N151	5.09	No	No	0	9	5
114	R:R:N151	R:R:S153	5.96	No	No	0	5	4
115	R:R:H160	R:R:R162	14.67	No	No	0	4	3
116	R:R:A165	R:R:Y167	5.34	No	Yes	0	7	5
117	R:R:N166	R:R:S168	8.94	No	No	0	7	6
118	R:R:L174	R:R:V171	5.96	No	No	0	3	3
119	R:R:E177	R:R:T175	4.23	No	No	0	1	1
120	R:R:E177	R:R:R179	11.63	No	No	1	1	3
121	R:R:E177	R:R:E180	8.88	No	Yes	1	1	3
122	R:R:R181	R:R:T178	7.76	No	No	0	3	3
123	R:R:E180	R:R:R179	6.98	Yes	No	1	3	3
124	R:R:R179	R:R:S433	3.95	No	No	1	3	3
125	R:R:E180	R:R:V432	4.28	Yes	Yes	1	3	5
126	R:R:E180	R:R:S433	4.31	Yes	No	1	3	3
127	R:R:E182	R:R:R186	13.96	No	No	0	2	5
128	R:R:Q438	R:R:V183	7.16	No	No	0	4	4
129	R:R:F184	R:R:V432	6.55	Yes	Yes	1	6	5
130	R:R:F184	R:R:W437	6.01	Yes	Yes	1	6	5
131	R:R:D185	R:R:M189	5.54	No	No	0	2	4
132	R:R:H442	R:R:R186	6.77	No	No	0	5	5
133	R:R:L187	R:R:M441	5.65	Yes	Yes	1	5	6
134	R:R:H442	R:R:L187	6.43	No	Yes	0	5	5
135	R:R:L187	R:R:M445	4.24	Yes	Yes	1	5	6
136	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
137	R:R:Y191	R:R:Y195	5.96	Yes	Yes	1	7	7
138	R:R:I237	R:R:Y191	4.84	Yes	Yes	1	7	7
139	R:R:M445	R:R:Y191	11.97	Yes	Yes	1	6	7
140	R:R:F450	R:R:G194	9.03	Yes	No	0	7	9
141	R:R:R233	R:R:Y195	9.26	Yes	Yes	1	8	7
142	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
143	R:R:I237	R:R:Y195	7.25	Yes	Yes	1	7	7
144	R:R:S449	R:R:Y195	7.63	No	Yes	0	9	7
145	R:R:F238	R:R:S196	5.28	No	No	0	7	7
146	R:R:F450	R:R:V197	3.93	Yes	No	0	7	5
147	R:R:F453	R:R:V197	5.24	Yes	No	0	6	5
148	R:R:L199	R:R:V235	4.47	No	No	0	7	4
149	R:R:F453	R:R:S201	5.28	Yes	No	0	6	8
150	R:R:F227	R:R:L202	7.31	Yes	No	0	9	9
151	R:R:M231	R:R:T203	4.52	Yes	No	0	8	3
152	R:R:F461	R:R:V204	5.24	No	No	0	8	5
153	R:R:A205	R:R:F227	4.16	No	Yes	0	9	9
154	R:R:L209	R:R:M224	5.65	No	No	0	7	5
155	R:R:F227	R:R:L209	4.87	Yes	No	0	9	7
156	R:R:F212	R:R:Y211	9.28	Yes	No	0	7	2
157	R:R:F212	R:R:L215	4.87	Yes	Yes	3	7	9
158	R:R:E469	R:R:F212	12.83	No	Yes	3	9	7
159	R:R:F212	R:R:S473	5.28	Yes	No	0	7	4
160	R:R:E469	R:R:R214	16.28	No	No	0	9	7
161	R:R:L215	R:R:N220	4.12	Yes	Yes	3	9	9
162	R:R:E465	R:R:L215	5.3	Yes	Yes	3	9	9
163	R:R:E469	R:R:L215	3.98	No	Yes	3	9	9
164	R:R:T218	R:R:Y305	8.74	No	Yes	0	7	8
165	R:R:E317	R:R:T218	9.88	No	No	2	6	7
166	R:R:L321	R:R:T218	5.9	No	No	2	6	7
167	R:R:N220	R:R:R219	13.26	Yes	No	3	9	9
168	R:R:H223	R:R:R219	6.77	No	No	0	9	9
169	R:R:E465	R:R:R219	5.82	Yes	No	3	9	9
170	R:R:E465	R:R:N220	5.26	Yes	Yes	3	9	9
171	R:R:H225	R:R:Y221	18.51	Yes	No	2	8	7
172	R:R:L321	R:R:Y221	7.03	No	No	2	6	7
173	R:R:T325	R:R:Y221	6.24	No	No	2	5	7
174	R:R:E302	R:R:I222	8.2	Yes	No	0	9	9
175	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
176	R:R:E302	R:R:H223	14.77	Yes	No	0	9	9
177	R:R:H225	R:R:W298	15.87	Yes	Yes	2	8	9
178	R:R:H225	R:R:T325	8.21	Yes	No	2	8	5
179	R:R:H225	R:R:W329	7.41	Yes	Yes	2	8	9
180	R:R:F230	R:R:L226	6.09	Yes	No	1	8	9
181	R:R:I299	R:R:L226	5.71	Yes	No	1	9	9
182	R:R:E302	R:R:L226	9.28	Yes	No	0	9	9
183	R:R:F227	R:R:V455	3.93	Yes	No	0	9	9
184	R:R:L228	R:R:W329	4.56	No	Yes	0	4	9
185	R:R:N295	R:R:S229	7.45	No	No	0	8	9
186	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
187	R:R:F230	R:R:N295	21.75	Yes	No	0	8	8
188	R:R:F230	R:R:I299	5.02	Yes	Yes	1	8	9
189	R:R:F230	R:R:Q451	10.54	Yes	Yes	1	8	9
190	R:R:F230	R:R:G452	9.03	Yes	No	0	8	9
191	R:R:F291	R:R:L232	19.49	Yes	No	0	5	8
192	R:R:L292	R:R:R233	9.72	No	Yes	1	6	8
193	R:R:N295	R:R:R233	14.46	No	Yes	0	8	8
194	R:R:R233	R:R:Y296	13.38	Yes	Yes	1	8	7
195	R:R:R233	R:R:Y421	5.14	Yes	Yes	1	8	8
196	R:R:F291	R:R:S236	9.25	Yes	No	0	5	7
197	R:R:F288	R:R:I237	5.02	Yes	Yes	1	7	7
198	R:R:K240	R:R:L244	4.23	No	Yes	1	7	5
199	R:R:F288	R:R:K240	17.37	Yes	No	1	7	7
200	R:R:L244	R:R:Y245	10.55	Yes	Yes	1	5	4
201	R:R:D353	R:R:L244	12.21	Yes	Yes	1	5	5
202	R:R:D353	R:R:Y245	9.2	Yes	Yes	1	5	4
203	R:R:C281	R:R:C351	7.28	No	No	0	9	9
204	R:R:N348	R:R:R282	9.64	No	No	0	7	8
205	R:R:R282	R:R:W352	35.99	No	Yes	0	8	8
206	R:R:T286	R:R:V340	4.76	No	No	0	7	5
207	R:R:F287	R:R:F291	5.36	No	Yes	0	3	5
208	R:R:F288	R:R:L289	6.09	Yes	Yes	1	7	7
209	R:R:L289	R:R:W339	5.69	Yes	Yes	1	7	8
210	R:R:I363	R:R:L289	7.14	No	Yes	1	7	7
211	R:R:F291	R:R:Y290	9.28	Yes	Yes	0	5	9
212	R:R:T294	R:R:Y290	8.74	No	Yes	2	8	9
213	R:R:P332	R:R:Y290	4.17	No	Yes	2	9	9
214	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
215	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
216	R:R:L292	R:R:Y296	5.86	No	Yes	1	6	7
217	R:R:A293	R:R:F335	4.16	No	Yes	0	6	5
218	R:R:T294	R:R:W329	8.49	No	Yes	2	8	9
219	R:R:P332	R:R:T294	6.99	No	No	2	9	8
220	R:R:I367	R:R:Y296	9.67	No	Yes	1	7	7
221	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
222	R:R:Y296	R:R:Y421	16.88	Yes	Yes	1	7	8
223	R:R:F327	R:R:Y297	5.16	No	Yes	1	5	6
224	R:R:L331	R:R:Y297	4.69	No	Yes	1	4	6
225	R:R:F335	R:R:Y297	6.19	Yes	Yes	1	5	6
226	R:R:P366	R:R:Y297	4.17	No	Yes	1	9	6
227	R:R:S370	R:R:Y297	3.82	No	Yes	0	7	6
228	R:R:V301	R:R:W298	8.58	No	Yes	0	8	9
229	R:R:G328	R:R:W298	8.44	No	Yes	0	9	9
230	R:R:W298	R:R:W329	26.24	Yes	Yes	2	9	9
231	R:R:I299	R:R:N374	4.25	Yes	No	0	9	9
232	R:R:I299	R:R:Q451	4.12	Yes	Yes	1	9	9
233	R:R:L300	R:R:L304	5.54	No	No	0	8	5
234	R:R:L300	R:R:S370	4.5	No	No	0	8	7
235	R:R:L300	R:R:L373	6.92	No	No	0	8	7
236	R:R:F324	R:R:V301	3.93	No	No	0	7	8
237	R:R:E302	R:R:L416	15.9	Yes	No	0	9	9
238	R:R:F417	R:R:G303	4.52	Yes	No	0	9	9
239	R:R:L304	R:R:L377	4.15	No	No	0	5	7
240	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
241	R:R:I381	R:R:L306	5.71	No	No	0	9	9
242	R:R:F417	R:R:L306	4.87	Yes	No	0	9	9
243	R:R:F311	R:R:H307	20.36	Yes	No	7	6	8
244	R:R:H307	R:R:L377	7.71	No	No	0	8	7
245	R:R:H307	R:R:N380	6.38	No	No	7	8	8
246	R:R:M312	R:R:S308	4.6	No	No	0	5	7
247	R:R:F315	R:R:S308	6.61	No	No	0	6	7
248	R:R:F311	R:R:I310	3.77	Yes	No	0	6	8
249	R:R:I310	R:R:V384	4.61	No	No	0	8	8
250	R:R:F311	R:R:N380	12.08	Yes	No	7	6	8
251	R:R:F311	R:R:R383	4.28	Yes	No	7	6	8
252	R:R:M312	R:R:Y320	7.18	No	Yes	0	5	4
253	R:R:A313	R:R:F314	5.55	No	No	0	7	7
254	R:R:F315	R:R:Y320	9.28	No	Yes	0	6	4
255	R:R:E317	R:R:L321	5.3	No	No	2	6	6
256	R:R:K319	R:R:Y320	4.78	No	Yes	0	6	4
257	R:R:G323	R:R:W322	5.63	No	No	0	1	3
258	R:R:V326	R:R:W322	8.58	No	No	0	4	3
259	R:R:F327	R:R:L331	6.09	No	No	1	5	4
260	R:R:F335	R:R:I363	5.02	Yes	No	1	5	7
261	R:R:F335	R:R:P366	18.78	Yes	No	1	5	9
262	R:R:F335	R:R:I367	5.02	Yes	No	1	5	7
263	R:R:R343	R:R:W339	4	Yes	Yes	1	8	8
264	R:R:W339	R:R:W352	4.69	Yes	Yes	1	8	8
265	R:R:I362	R:R:W339	4.7	No	Yes	0	8	8
266	R:R:I363	R:R:W339	14.09	No	Yes	1	7	8
267	R:R:I362	R:R:V342	4.61	No	No	0	8	5
268	R:R:A347	R:R:R343	4.15	No	Yes	0	7	8
269	R:R:R343	R:R:W352	25.99	Yes	Yes	1	8	8
270	R:R:R343	R:R:S356	11.86	Yes	No	0	8	4
271	R:R:L346	R:R:T345	4.42	No	No	0	3	3
272	R:R:K359	R:R:L346	4.23	No	No	0	3	3
273	R:R:K359	R:R:S356	6.12	No	No	0	3	4
274	R:R:N358	R:R:W361	7.91	No	No	0	4	8
275	R:R:K360	R:R:W361	12.76	No	No	0	7	8
276	R:R:K360	R:R:Y429	19.11	No	Yes	1	7	6
277	R:R:Q364	R:R:W361	10.95	Yes	No	0	7	8
278	R:R:Q364	R:R:Y429	4.51	Yes	Yes	1	7	6
279	R:R:L368	R:R:M425	9.9	No	No	0	4	6
280	R:R:I371	R:R:Y421	6.04	No	Yes	1	7	8
281	R:R:F417	R:R:N374	12.08	Yes	No	0	9	9
282	R:R:F375	R:R:I379	5.02	No	No	0	7	5
283	R:R:F375	R:R:I422	13.82	No	No	0	7	5
284	R:R:F378	R:R:V382	5.24	Yes	No	5	9	7
285	R:R:F378	R:R:T410	3.89	Yes	No	5	9	9
286	R:R:F378	R:R:L413	6.09	Yes	No	5	9	9
287	R:R:F378	R:R:F417	11.79	Yes	Yes	5	9	9
288	R:R:F378	R:R:V419	11.8	Yes	No	0	9	7
289	R:R:N380	R:R:R383	8.44	No	No	7	8	8
290	R:R:T410	R:R:V382	4.76	No	No	5	9	7
291	R:R:L385	R:R:S409	4.5	No	No	0	8	9
292	R:R:A386	R:R:L406	4.73	No	Yes	0	6	8
293	R:R:R390	R:R:T387	9.06	No	No	0	6	7
294	R:R:K405	R:R:L389	5.64	No	Yes	0	8	8
295	R:R:R400	R:R:Y403	4.12	No	No	0	8	7
296	R:R:K408	R:R:V412	4.55	No	No	0	8	8
297	R:R:I458	R:R:V412	4.61	No	No	0	8	8
298	R:R:F417	R:R:L413	10.96	Yes	No	5	9	9
299	R:R:M414	R:R:V419	7.61	No	No	0	8	7
300	R:R:I458	R:R:P415	5.08	No	No	0	8	9
301	R:R:F417	R:R:L416	4.87	Yes	No	0	9	9
302	R:R:L416	R:R:Y459	22.27	No	No	0	9	8
303	R:R:H420	R:R:Y421	16.33	Yes	Yes	1	8	8
304	R:R:H420	R:R:Y443	4.36	Yes	Yes	1	8	4
305	R:R:F447	R:R:H420	9.05	No	Yes	1	5	8
306	R:R:H420	R:R:N448	8.93	Yes	No	1	8	6
307	R:R:H420	R:R:Q451	11.13	Yes	Yes	1	8	9
308	R:R:N448	R:R:Y421	15.12	No	Yes	1	6	8
309	R:R:Q451	R:R:Y421	9.02	Yes	Yes	1	9	8
310	R:R:F424	R:R:V423	7.87	Yes	No	1	7	6
311	R:R:V423	R:R:Y443	11.36	No	Yes	1	6	4
312	R:R:F424	R:R:T427	6.49	Yes	No	1	7	5
313	R:R:F424	R:R:Q440	14.05	Yes	No	1	7	6
314	R:R:F424	R:R:Y443	7.22	Yes	Yes	1	7	4
315	R:R:E444	R:R:F424	7	Yes	Yes	1	7	7
316	R:R:Q440	R:R:T427	14.17	No	No	1	6	5
317	R:R:T430	R:R:W437	6.06	No	Yes	0	5	5
318	R:R:V432	R:R:W437	19.61	Yes	Yes	1	5	5
319	R:R:M441	R:R:W437	22.1	Yes	Yes	1	6	5
320	R:R:H442	R:R:Q438	6.18	No	No	0	5	4
321	R:R:E444	R:R:Y443	4.49	Yes	Yes	1	7	4
322	R:R:F447	R:R:Y443	10.32	No	Yes	1	5	4
323	R:R:E444	R:R:N448	13.15	Yes	No	1	7	6
324	R:R:F450	R:R:L446	4.87	Yes	No	0	7	5
325	R:R:F450	R:R:S449	5.28	Yes	No	0	7	9
326	R:R:F450	R:R:F454	4.29	Yes	No	0	7	6
327	R:R:F453	R:R:F454	5.36	Yes	No	0	6	6
328	R:R:F453	R:R:I457	10.05	Yes	No	0	6	6
329	R:R:F461	R:R:I457	8.79	No	No	0	8	6
330	R:R:I458	R:R:Y459	8.46	No	No	0	8	8
331	R:R:E465	R:R:N463	5.26	Yes	No	0	9	9
332	R:R:N463	R:R:V466	8.87	No	No	0	9	9
333	R:R:K471	R:R:S475	7.65	No	No	0	5	4
334	R:R:K472	R:R:R476	18.56	No	No	0	7	7
335	R:R:R476	R:R:S473	9.22	No	No	0	7	4
336	R:R:T478	R:R:W474	10.92	No	No	0	4	5
337	R:R:G452	R:R:S198	3.71	No	No	0	9	9
338	R:R:S475	R:R:W474	3.71	No	No	0	4	5
339	R:R:V340	R:R:W339	3.68	No	Yes	1	5	8
340	R:R:V340	R:R:W352	3.68	No	Yes	1	5	8
341	R:R:A205	R:R:C460	3.61	No	No	0	9	9
342	R:R:P119	R:R:V127	3.53	No	No	0	6	7
343	R:R:P130	R:R:V129	3.53	No	No	0	5	5
344	R:R:P158	R:R:V157	3.53	No	No	0	4	4
345	R:R:P366	R:R:V365	3.53	No	No	0	9	5
346	R:R:D133	R:R:Y134	3.45	No	Yes	0	2	5
347	R:R:D241	R:R:Y245	3.45	No	Yes	0	8	4
348	R:R:A456	R:R:S201	3.42	No	No	0	8	8
349	R:R:G452	R:R:L202	3.42	No	No	0	9	9
350	R:R:C460	R:R:V466	3.42	No	No	0	9	9
351	R:R:H216	R:R:R213	3.39	No	No	0	8	8
352	R:R:A284	R:R:V243	3.39	No	No	0	6	5
353	R:R:Q402	R:R:Y403	3.38	No	No	0	6	7
354	R:R:G418	R:R:Q451	3.29	No	Yes	0	9	9
355	R:R:G464	R:R:Q467	3.29	No	No	0	7	8
356	R:R:L52	R:R:P110	3.28	No	No	0	4	6
357	R:R:L120	R:R:P110	3.28	No	No	0	4	6
358	R:R:C460	R:R:I208	3.27	No	No	0	9	8
359	R:R:S341	R:R:V342	3.23	No	No	0	5	5
360	R:R:C351	R:R:L244	3.17	No	Yes	0	9	5
361	R:R:A344	R:R:N348	3.13	No	No	0	4	7
362	R:R:F315	R:R:Y305	3.09	No	Yes	0	6	8
363	R:R:F324	R:R:Y320	3.09	No	Yes	0	7	4
364	R:R:I362	R:R:V338	3.07	No	No	0	8	5
365	R:R:I376	R:R:V372	3.07	No	No	0	4	4
366	L:L:M8	R:R:V285	3.04	Yes	No	0	0	6
367	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
368	R:R:M425	R:R:V372	3.04	No	No	0	6	4
369	R:R:K388	R:R:V384	3.04	No	No	0	9	8
370	L:L:A1	L:L:Q6	3.03	No	Yes	0	0	0
371	R:R:A122	R:R:E125	3.02	No	No	0	1	5
372	R:R:L406	R:R:S409	3	Yes	No	0	8	9
373	L:L:V2	R:R:L368	2.98	Yes	No	0	0	4
374	R:R:L331	R:R:V334	2.98	No	No	0	4	4
375	R:R:L406	R:R:T410	2.95	Yes	No	0	8	9
376	R:R:I371	R:R:I422	2.94	No	No	0	7	5
377	R:R:I190	R:R:M445	2.92	No	Yes	0	6	6
378	L:L:I28	L:L:L24	2.85	No	No	0	0	0
379	R:R:L199	R:R:M231	2.83	No	Yes	0	7	8
380	R:R:L202	R:R:M231	2.83	No	Yes	0	9	8
381	R:R:L228	R:R:M231	2.83	No	Yes	0	4	8
382	R:R:Q402	R:R:T399	2.83	No	No	0	6	6
383	R:R:E391	R:R:T387	2.82	No	No	0	7	7
384	R:R:A234	R:R:F238	2.77	No	No	0	8	7
385	R:R:L389	R:R:L406	2.77	Yes	Yes	0	8	8
386	R:R:L407	R:R:L411	2.77	No	No	0	8	8
387	R:R:D137	R:R:L174	2.71	Yes	No	0	5	3
388	R:R:H42	R:R:I38	2.65	No	No	0	4	7
389	R:R:R162	R:R:V157	2.62	No	No	0	3	4
390	R:R:E49	R:R:Q45	2.55	No	No	0	6	7
391	R:R:H160	R:R:N161	2.55	No	No	0	4	7
392	R:R:T192	R:R:Y191	2.5	No	Yes	0	7	7
393	R:R:F173	R:R:K172	2.48	No	No	0	3	3
394	R:R:L41	R:R:W112	2.28	No	Yes	0	8	7
395	R:R:R400	R:R:R404	2.13	No	No	0	8	6
396	R:R:G277	R:R:G350	2.11	No	No	0	4	5
397	R:R:G330	R:R:P332	2.03	No	No	0	7	9
398	R:R:C131	R:R:G142	1.96	No	No	0	9	5
399	R:R:C351	R:R:G277	1.96	No	No	0	9	4
400	R:R:A122	R:R:P123	1.87	No	No	0	1	7
401	R:R:G121	R:R:V127	1.84	No	No	0	7	7
402	R:R:G194	R:R:V193	1.84	No	No	0	9	6
403	R:R:G280	R:R:V283	1.84	No	No	0	4	4
404	R:R:G350	R:R:T349	1.82	No	No	0	5	5
405	R:R:P428	R:R:T427	1.75	No	No	0	7	5
406	R:R:P428	R:R:T430	1.75	No	No	0	7	5
407	R:R:A242	R:R:S246	1.71	No	No	0	4	4
408	R:R:A122	R:R:V127	1.7	No	No	0	1	7
409	R:R:G142	R:R:N139	1.7	No	No	0	5	4
410	R:R:A284	R:R:V239	1.7	No	No	0	6	5
411	R:R:G464	R:R:N463	1.7	No	No	0	7	9
412	R:R:A200	R:R:T203	1.68	No	No	0	3	3
413	R:R:C462	R:R:I457	1.64	No	No	0	6	6
414	R:R:A210	R:R:M224	1.61	No	No	0	4	5
415	R:R:C217	R:R:N220	1.57	No	Yes	0	8	9
416	L:L:K13	R:R:S355	1.53	No	No	0	0	7
417	R:R:K319	R:R:S316	1.53	No	No	0	6	7
418	L:L:K13	R:R:V31	1.52	No	Yes	0	0	6
419	R:R:G152	R:R:R106	1.5	No	No	0	9	1
420	R:R:G124	R:R:R150	1.5	No	No	0	7	1
421	R:R:L436	R:R:V439	1.49	No	No	0	4	5
422	R:R:L156	R:R:T163	1.47	No	No	0	4	5
423	R:R:L389	R:R:T392	1.47	Yes	No	0	8	7
424	R:R:L436	R:R:T430	1.47	No	No	0	4	5
425	R:R:A128	R:R:H143	1.46	No	No	0	5	3
426	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
427	R:R:L389	R:R:Q402	1.33	Yes	No	0	8	6
428	R:R:H216	R:R:M224	1.31	No	No	0	8	5
429	R:R:F287	R:R:V283	1.31	No	No	0	3	4
430	L:L:R20	R:R:K34	1.24	Yes	No	0	0	4
431	R:R:F39	R:R:L40	1.22	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:V2	6.146	5	1	0
2	L:L:E4	7.6425	4	1	0
3	L:L:I5	7.944	5	1	0
4	L:L:Q6	11.365	4	1	0
5	L:L:M8	6.87	5	1	0
6	L:L:H9	8.454	5	1	0
7	L:L:Q10	6.1225	4	1	0
8	L:L:W14	6.218	5	1	0
9	L:L:R20	10.2875	4	0	0
10	R:R:V31	4.7425	4	8	6
11	R:R:Q37	4.85	4	4	7
12	R:R:W112	10.315	4	0	7
13	R:R:W118	10.2875	4	6	9
14	R:R:P132	6.915	4	4	9
15	R:R:Y134	5.97	6	4	5
16	R:R:I135	9.7575	4	4	7
17	R:R:D137	7.65	4	0	5
18	R:R:F138	11.0675	4	4	4
19	R:R:Y145	13.5725	4	10	4
20	R:R:R146	12.665	4	6	8
21	R:R:W154	8.715	4	0	9
22	R:R:Y167	7.63167	6	6	5
23	R:R:E180	6.1125	4	1	3
24	R:R:F184	10.4225	4	1	6
25	R:R:L187	5.1175	4	1	5
26	R:R:Y191	6.212	5	1	7
27	R:R:Y195	7.74167	6	1	7
28	R:R:F212	8.065	4	3	7
29	R:R:L215	4.5675	4	3	9
30	R:R:N220	6.0525	4	3	9
31	R:R:H225	12.5	4	2	8
32	R:R:F227	5.0675	4	0	9
33	R:R:F230	10.486	5	1	8
34	R:R:M231	3.21	5	0	8
35	R:R:R233	9.435	6	1	8
36	R:R:I237	5.3025	4	1	7
37	R:R:L244	7.54	4	1	5
38	R:R:Y245	10.945	4	1	4
39	R:R:F288	8.675	4	1	7
40	R:R:L289	6.1575	4	1	7
41	R:R:Y290	6.516	5	2	9
42	R:R:F291	10.845	4	0	5
43	R:R:Y296	9.07	6	1	7
44	R:R:Y297	4.806	5	1	6
45	R:R:W298	13.308	5	2	9
46	R:R:I299	4.775	4	1	9
47	R:R:E302	12.0375	4	0	9
48	R:R:Y305	8.8825	4	0	8
49	R:R:F311	10.1225	4	7	6
50	R:R:Y320	6.0825	4	0	4
51	R:R:W329	11.675	4	2	9
52	R:R:F335	7.834	5	1	5
53	R:R:W339	6.14167	6	1	8
54	R:R:R343	11.5	4	1	8
55	R:R:W352	17.5875	4	1	8
56	R:R:D353	8.9775	4	1	5
57	R:R:Q364	9.1025	4	1	7
58	R:R:F378	7.762	5	5	9
59	R:R:L389	2.8025	4	0	8
60	R:R:L406	3.3625	4	0	8
61	R:R:F417	8.18167	6	5	9
62	R:R:H420	9.96	5	1	8
63	R:R:Y421	11.4217	6	1	8
64	R:R:F424	8.526	5	1	7
65	R:R:Y429	14.32	5	1	6
66	R:R:V432	9.0425	4	1	5
67	R:R:W437	12.07	5	1	5
68	R:R:M441	9.71	4	1	6
69	R:R:Y443	7.55	5	1	4
70	R:R:E444	7.6675	4	1	7
71	R:R:M445	6.85	5	1	6
72	R:R:F450	5.48	5	0	7
73	R:R:Q451	7.62	5	1	9
74	R:R:F453	6.4825	4	0	6
75	R:R:E465	5.41	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I5	L:L:V2	19.0537	10.75	Yes	Yes	1	0	0
2	L:L:V2	R:R:Y296	23.0739	3.79	Yes	Yes	1	0	7
3	L:L:I5	R:R:L292	68.3224	4.28	Yes	No	1	0	6
4	R:R:L292	R:R:Y296	12.386	5.86	No	Yes	1	6	7
5	R:R:R233	R:R:Y421	19.4668	5.14	Yes	Yes	1	8	8
6	R:R:L292	R:R:R233	56.0407	9.72	No	Yes	1	6	8
7	R:R:Y296	R:R:Y421	36.2527	16.88	Yes	Yes	1	7	8
8	L:L:E4	R:R:R233	19.9841	4.65	Yes	Yes	1	0	8
9	R:R:R233	R:R:Y195	24.238	9.26	Yes	Yes	1	8	7
10	L:L:I5	R:R:L289	21.1065	5.71	Yes	Yes	1	0	7
11	R:R:F288	R:R:I237	23.9543	5.02	Yes	Yes	1	7	7
12	L:L:E4	R:R:M445	17.126	9.47	Yes	Yes	1	0	6
13	L:L:H9	L:L:I5	84.2092	6.63	Yes	Yes	1	0	0
14	L:L:H9	R:R:Y429	13.2247	14.16	Yes	Yes	1	0	6
15	L:L:Q10	R:R:Y429	16.8485	4.51	Yes	Yes	1	0	6
16	R:R:Q364	R:R:Y429	11.3116	4.51	Yes	Yes	1	7	6
17	R:R:L187	R:R:M445	11.5641	4.24	Yes	Yes	1	5	6
18	L:L:H9	L:L:M8	18.3694	5.25	Yes	Yes	1	0	0
19	L:L:M8	R:R:D353	11.3054	8.32	Yes	Yes	1	0	5
20	L:L:H9	R:R:S355	100	8.37	Yes	No	0	0	7
21	L:L:Q10	R:R:V432	10.1308	5.73	Yes	Yes	1	0	5
22	L:L:K13	R:R:S355	99.2969	1.53	No	No	0	0	7
23	L:L:K13	R:R:V31	98.5897	1.52	No	Yes	0	0	6
24	L:L:D17	R:R:V31	94.2587	4.38	No	Yes	0	0	6
25	L:L:D17	L:L:R20	93.5222	17.87	No	Yes	0	0	0
26	L:L:R20	R:R:Y136	17.3367	11.32	Yes	No	0	0	4
27	L:L:R20	R:R:D137	71.8774	10.72	Yes	Yes	0	0	5
28	L:L:L24	R:R:D137	68.0074	4.07	No	Yes	0	0	5
29	L:L:L24	R:R:F138	66.4365	9.74	No	Yes	0	0	4
30	R:R:I115	R:R:L116	56.7146	4.28	No	No	0	5	5
31	R:R:L116	R:R:P132	57.645	9.85	No	Yes	0	5	9
32	R:R:F138	R:R:P132	56.0449	5.78	Yes	Yes	4	4	9
33	L:L:H32	R:R:Y167	14.7477	7.62	No	Yes	0	0	5
34	R:R:I115	R:R:Y167	54.8224	16.92	No	Yes	0	5	5
35	L:L:H32	R:R:N166	13.667	3.83	No	No	0	0	7
36	R:R:M32	R:R:Y136	16.6357	8.38	No	No	0	6	4
37	R:R:M32	R:R:Q37	15.9556	4.08	No	Yes	0	6	7
38	R:R:Q37	R:R:Y134	10.5376	4.51	Yes	Yes	4	7	5
39	R:R:D113	R:R:Y167	18.4967	8.05	No	Yes	6	9	5
40	R:R:D113	R:R:R146	17.4431	7.15	No	Yes	6	9	8
41	R:R:R146	R:R:W154	28.5023	8	Yes	Yes	0	8	9
42	R:R:G121	R:R:W154	19.786	4.22	No	Yes	0	7	9
43	R:R:G121	R:R:V127	15.434	1.84	No	No	0	7	7
44	R:R:A122	R:R:V127	11.0446	1.7	No	No	0	1	7
45	R:R:W118	R:R:Y167	20.658	3.86	Yes	Yes	6	9	5
46	R:R:R146	R:R:W118	17.4953	19.99	Yes	Yes	6	8	9
47	R:R:N166	R:R:Y145	11.4305	5.81	No	Yes	0	7	4
48	R:R:C170	R:R:F138	11.514	11.17	No	Yes	0	9	4
49	R:R:C131	R:R:C170	10.3812	7.28	No	No	0	9	9
50	R:R:S449	R:R:Y195	26.0655	7.63	No	Yes	0	9	7
51	R:R:F450	R:R:S449	24.866	5.28	Yes	No	0	7	9
52	R:R:F450	R:R:V197	10.014	3.93	Yes	No	0	7	5
53	R:R:F450	R:R:F454	10.014	4.29	Yes	No	0	7	6
54	R:R:N295	R:R:R233	74.118	14.46	No	Yes	0	8	8
55	R:R:F230	R:R:N295	53.7375	21.75	Yes	No	0	8	8
56	R:R:F230	R:R:G452	17.8833	9.03	Yes	No	0	8	9
57	R:R:G452	R:R:L202	16.11	3.42	No	No	0	9	9
58	R:R:F227	R:R:L202	11.0425	7.31	Yes	No	0	9	9
59	R:R:F453	R:R:I457	10.0536	10.05	Yes	No	0	6	6
60	R:R:F230	R:R:L226	32.4182	6.09	Yes	No	1	8	9
61	R:R:E302	R:R:L226	37.2854	9.28	Yes	No	0	9	9
62	R:R:E302	R:R:H223	26.4849	14.77	Yes	No	0	9	9
63	R:R:H223	R:R:R219	25.4167	6.77	No	No	0	9	9
64	R:R:N220	R:R:R219	11.0049	13.26	Yes	No	3	9	9
65	R:R:F212	R:R:L215	11.3784	4.87	Yes	Yes	3	7	9
66	R:R:E465	R:R:R219	13.3666	5.82	Yes	No	3	9	9
67	R:R:N295	R:R:S229	25.5356	7.45	No	No	0	8	9
68	R:R:S229	R:R:W298	24.722	7.41	No	Yes	0	9	9
69	R:R:W298	R:R:W329	12.5237	26.24	Yes	Yes	2	9	9
70	R:R:Q451	R:R:Y421	43.9176	9.02	Yes	Yes	1	9	8
71	R:R:I299	R:R:Q451	38.4641	4.12	Yes	Yes	1	9	9
72	R:R:F230	R:R:I299	14.2407	5.02	Yes	Yes	1	8	9
73	R:R:T294	R:R:W329	11.6392	8.49	No	Yes	2	8	9
74	R:R:K240	R:R:L244	10.2643	4.23	No	Yes	1	7	5
75	R:R:L289	R:R:W339	17.3054	5.69	Yes	Yes	1	7	8
76	R:R:F335	R:R:I367	21.1712	5.02	Yes	No	1	5	7
77	R:R:F335	R:R:Y297	21.1712	6.19	Yes	Yes	1	5	6
78	R:R:S370	R:R:Y297	16.352	3.82	No	Yes	0	7	6
79	R:R:I299	R:R:N374	45.4968	4.25	Yes	No	0	9	9
80	R:R:L300	R:R:S370	15.119	4.5	No	No	0	8	7
81	R:R:L300	R:R:L304	12.6406	5.54	No	No	0	8	5
82	R:R:F417	R:R:N374	43.6943	12.08	Yes	No	0	9	9
83	R:R:L304	R:R:L377	11.3951	4.15	No	No	0	5	7
84	R:R:H307	R:R:L377	10.1454	7.71	No	No	0	8	7
85	R:R:F378	R:R:F417	35.5225	11.79	Yes	Yes	5	9	9
86	R:R:F378	R:R:T410	27.745	3.89	Yes	No	5	9	9
87	R:R:L406	R:R:T410	25.8173	2.95	Yes	No	0	8	9
88	R:R:L389	R:R:L406	17.948	2.77	Yes	Yes	0	8	8
89	R:R:L389	R:R:Q402	12.0022	1.33	Yes	No	0	8	6
90	R:R:R233	R:R:Y296	11.4681	13.38	Yes	Yes	1	8	7
91	R:R:I237	R:R:Y195	14.5703	7.25	Yes	Yes	1	7	7
92	R:R:I367	R:R:Y296	15.1274	9.67	No	Yes	1	7	7
93	R:R:M441	R:R:W437	12.5988	22.1	Yes	Yes	1	6	5
94	L:L:M8	R:R:F288	14.5808	6.22	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Y296	3.79	1	Yes	Yes	0	7	0	1
L:L:V2	R:R:Q364	8.6	1	Yes	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	1	Yes	No	0	7	0	1
L:L:A3	R:R:E444	6.03	0	No	Yes	0	7	0	1
L:L:E4	R:R:Y195	12.35	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R233	4.65	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:I237	4.1	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:M445	9.47	1	Yes	Yes	0	6	0	1
L:L:I5	R:R:L289	5.71	1	Yes	Yes	0	7	0	1
L:L:I5	R:R:L292	4.28	1	Yes	No	0	6	0	1
L:L:I5	R:R:Q364	12.35	1	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	29.31	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	5.44	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:L187	4.15	1	No	Yes	0	5	0	1
L:L:L7	R:R:M441	5.65	1	No	Yes	0	6	0	1
L:L:L7	R:R:M445	5.65	1	No	Yes	0	6	0	1
L:L:M8	R:R:K240	11.52	1	Yes	No	0	7	0	1
L:L:M8	R:R:F288	6.22	1	Yes	Yes	0	7	0	1
L:L:M8	R:R:D353	8.32	1	Yes	Yes	0	5	0	1
L:L:H9	R:R:S355	8.37	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	7.86	1	Yes	No	0	7	0	1
L:L:H9	R:R:Y429	14.16	1	Yes	Yes	0	6	0	1
L:L:Q10	R:R:Y429	4.51	1	Yes	Yes	0	6	0	1
L:L:Q10	R:R:V432	5.73	1	Yes	Yes	0	5	0	1
L:L:Q10	R:R:W437	6.57	1	Yes	Yes	0	5	0	1
L:L:R11	R:R:F184	17.1	1	No	Yes	0	6	0	1
L:L:R11	R:R:Y245	20.58	1	No	Yes	0	4	0	1
L:L:A12	R:R:D353	6.18	0	No	Yes	0	5	0	1
L:L:W14	R:R:R181	4	1	Yes	No	0	3	0	1
L:L:W14	R:R:F184	12.03	1	Yes	Yes	0	6	0	1
L:L:Q16	R:R:V31	8.6	8	No	Yes	0	6	0	1
L:L:Q16	R:R:T33	4.25	8	No	No	0	7	0	1
L:L:Q16	R:R:L354	6.65	8	No	No	0	5	0	1
L:L:D17	R:R:V31	4.38	0	No	Yes	0	6	0	1
L:L:R20	R:R:Y136	11.32	0	Yes	No	0	4	0	1
L:L:R20	R:R:D137	10.72	0	Yes	Yes	0	5	0	1
L:L:R21	R:R:D137	13.1	0	No	Yes	0	5	0	1
L:L:F23	R:R:K34	22.33	9	No	No	0	4	0	1
L:L:F23	R:R:I38	5.02	9	No	No	0	7	0	1
L:L:L24	R:R:D137	4.07	0	No	Yes	0	5	0	1
L:L:L24	R:R:F138	9.74	0	No	Yes	0	4	0	1
L:L:H25	R:R:L174	3.86	0	No	No	0	3	0	1
L:L:I31	R:R:I115	5.89	0	No	No	0	5	0	1
L:L:H32	R:R:N166	3.83	0	No	No	0	7	0	1
L:L:H32	R:R:Y167	7.62	0	No	Yes	0	5	0	1
R:R:L354	R:R:V31	4.47	8	No	Yes	5	6	1	1
R:R:M32	R:R:Y136	8.38	0	No	No	6	4	2	1
R:R:E36	R:R:T33	11.29	0	No	No	6	7	2	1
R:R:I38	R:R:K34	4.36	9	No	No	7	4	1	1
R:R:D113	R:R:W118	11.17	6	No	Yes	9	9	2	2
R:R:D113	R:R:Y167	8.05	6	No	Yes	9	5	2	1
R:R:I115	R:R:L116	4.28	0	No	No	5	5	1	2
R:R:I115	R:R:Y167	16.92	0	No	Yes	5	5	1	1
R:R:L116	R:R:P132	9.85	0	No	Yes	5	9	2	2
R:R:W118	R:R:Y167	3.86	6	Yes	Yes	9	5	2	1
R:R:I135	R:R:P132	5.08	4	Yes	Yes	7	9	2	2
R:R:F138	R:R:P132	5.78	4	Yes	Yes	4	9	1	2
R:R:F138	R:R:I135	17.58	4	Yes	Yes	4	7	1	2
R:R:C170	R:R:F138	11.17	0	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	4	0	No	Yes	7	5	2	1
R:R:N166	R:R:Y145	5.81	0	No	Yes	7	4	1	2
R:R:A165	R:R:Y167	5.34	0	No	Yes	7	5	2	1
R:R:N166	R:R:S168	8.94	0	No	No	7	6	1	2
R:R:L174	R:R:V171	5.96	0	No	No	3	3	1	2
R:R:R181	R:R:T178	7.76	0	No	No	3	3	1	2
R:R:E180	R:R:V432	4.28	1	Yes	Yes	3	5	2	1
R:R:F184	R:R:V432	6.55	1	Yes	Yes	6	5	1	1
R:R:F184	R:R:W437	6.01	1	Yes	Yes	6	5	1	1
R:R:L187	R:R:M441	5.65	1	Yes	Yes	5	6	1	1
R:R:H442	R:R:L187	6.43	0	No	Yes	5	5	2	1
R:R:L187	R:R:M445	4.24	1	Yes	Yes	5	6	1	1
R:R:Y191	R:R:Y195	5.96	1	Yes	Yes	7	7	2	1
R:R:I237	R:R:Y191	4.84	1	Yes	Yes	7	7	1	2
R:R:M445	R:R:Y191	11.97	1	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	9.26	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	4	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	7.25	1	Yes	Yes	7	7	1	1
R:R:S449	R:R:Y195	7.63	0	No	Yes	9	7	2	1
R:R:L292	R:R:R233	9.72	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	14.46	0	No	Yes	8	8	2	1
R:R:R233	R:R:Y296	13.38	1	Yes	Yes	8	7	1	1
R:R:R233	R:R:Y421	5.14	1	Yes	Yes	8	8	1	2
R:R:F288	R:R:I237	5.02	1	Yes	Yes	7	7	1	1
R:R:K240	R:R:L244	4.23	1	No	Yes	7	5	1	2
R:R:F288	R:R:K240	17.37	1	Yes	No	7	7	1	1
R:R:L244	R:R:Y245	10.55	1	Yes	Yes	5	4	2	1
R:R:D353	R:R:L244	12.21	1	Yes	Yes	5	5	1	2
R:R:D353	R:R:Y245	9.2	1	Yes	Yes	5	4	1	1
R:R:F288	R:R:L289	6.09	1	Yes	Yes	7	7	1	1
R:R:L289	R:R:W339	5.69	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	7.14	1	No	Yes	7	7	2	1
R:R:L292	R:R:Y296	5.86	1	No	Yes	6	7	1	1
R:R:I367	R:R:Y296	9.67	1	No	Yes	7	7	1	1
R:R:I371	R:R:Y296	4.84	1	No	Yes	7	7	2	1
R:R:Y296	R:R:Y421	16.88	1	Yes	Yes	7	8	1	2
R:R:F335	R:R:I363	5.02	1	Yes	No	5	7	2	2
R:R:F335	R:R:I367	5.02	1	Yes	No	5	7	2	1
R:R:I363	R:R:W339	14.09	1	No	Yes	7	8	2	2
R:R:K360	R:R:W361	12.76	1	No	No	7	8	1	2
R:R:K360	R:R:Y429	19.11	1	No	Yes	7	6	1	1
R:R:Q364	R:R:W361	10.95	1	Yes	No	7	8	1	2
R:R:Q364	R:R:Y429	4.51	1	Yes	Yes	7	6	1	1
R:R:L368	R:R:M425	9.9	0	No	No	4	6	1	2
R:R:I371	R:R:Y421	6.04	1	No	Yes	7	8	2	2
R:R:N448	R:R:Y421	15.12	1	No	Yes	6	8	2	2
R:R:F424	R:R:Y443	7.22	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	7	1	Yes	Yes	7	7	1	2
R:R:T430	R:R:W437	6.06	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	19.61	1	Yes	Yes	5	5	1	1
R:R:M441	R:R:W437	22.1	1	Yes	Yes	6	5	1	1
R:R:E444	R:R:Y443	4.49	1	Yes	Yes	7	4	1	2
R:R:E444	R:R:N448	13.15	1	Yes	No	7	6	1	2
R:R:D241	R:R:Y245	3.45	0	No	Yes	8	4	2	1
L:L:M8	R:R:V285	3.04	1	Yes	No	0	6	0	1
L:L:V2	R:R:L368	2.98	1	Yes	No	0	4	0	1
R:R:I190	R:R:M445	2.92	0	No	Yes	6	6	2	1
R:R:D137	R:R:L174	2.71	0	Yes	No	5	3	1	1
R:R:H42	R:R:I38	2.65	0	No	No	4	7	2	1
L:L:K13	R:R:S355	1.53	0	No	No	0	7	0	1
L:L:K13	R:R:V31	1.52	0	No	Yes	0	6	0	1
L:L:R20	R:R:K34	1.24	0	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FLU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	371
Number of Links	431
Number of Hubs	75
Number of Links mediated by Hubs	259
Number of Communities	10
Number of Nodes involved in Communities	105
Number of Links involved in Communities	157

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	116142
Length Of Smallest Path	3
Average Path Length	15.9629
Length of Longest Path	38
Minimum Path Strength	1.4
Average Path Strength	7.83205
Maximum Path Strength	30.99
Minimum Path Correlation	0.71
Average Path Correlation	0.959819
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	62.8232
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.6336
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • plasma membrane region • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8FLU_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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