psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:C10	A:A:L12	4.76	No	No	0	5	2
2	A:A:D16	A:A:L12	8.14	No	No	0	4	2
3	A:A:K17	A:A:L12	4.23	No	No	0	3	2
4	A:A:K24	A:A:V20	4.55	No	No	0	4	3
5	A:A:V20	B:B:N88	2.96	No	Yes	0	3	7
6	A:A:I26	A:A:R22	2.51	No	No	0	9	5
7	A:A:R22	B:B:H91	3.39	No	Yes	0	5	5
8	A:A:E27	A:A:S23	2.87	No	No	6	6	7
9	A:A:S23	B:B:N88	5.96	No	Yes	6	7	7
10	A:A:S23	B:B:K89	3.06	No	Yes	6	7	9
11	A:A:I26	B:B:K89	7.27	No	Yes	0	9	9
12	A:A:E27	B:B:K89	9.45	No	Yes	6	6	9
13	A:A:K32	A:A:Q29	2.71	No	No	0	4	4
14	A:A:D33	A:A:Q29	5.22	No	No	0	5	4
15	A:A:L30	B:B:K78	4.23	No	No	0	5	8
16	A:A:L30	B:B:K89	2.82	No	Yes	0	5	9
17	A:A:D33	B:B:K78	5.53	No	No	0	5	8
18	A:A:K34	B:B:L55	4.23	No	No	0	4	6
19	A:A:R42	A:A:Y37	7.2	No	No	0	9	4
20	A:A:Y37	B:B:L55	4.69	No	No	0	4	6
21	A:A:Y37	B:B:A56	2.67	No	No	0	4	7
22	A:A:R38	R:R:T136	2.59	No	No	0	4	4
23	A:A:R39	R:R:H133	7.9	No	No	0	5	5
24	A:A:N218	A:A:T40	2.92	No	No	0	4	7
25	A:A:L41	A:A:V217	2.98	Yes	No	5	6	5
26	A:A:F219	A:A:L41	6.09	Yes	Yes	5	8	6
27	A:A:L41	A:A:T242	5.9	Yes	No	0	6	8
28	A:A:I383	A:A:L41	2.85	No	Yes	0	8	6
29	A:A:F222	A:A:R42	4.28	Yes	No	0	7	9
30	A:A:F212	A:A:L43	2.44	Yes	No	5	9	7
31	A:A:F219	A:A:L43	7.31	Yes	No	5	8	7
32	A:A:I245	A:A:L43	2.85	Yes	No	5	7	7
33	A:A:L44	A:A:L46	5.54	No	Yes	1	9	8
34	A:A:F238	A:A:L44	14.61	Yes	No	1	9	9
35	A:A:I244	A:A:L44	5.71	Yes	No	1	8	9
36	A:A:K53	A:A:L45	5.64	No	Yes	0	9	8
37	A:A:L45	A:A:M221	4.24	Yes	Yes	0	8	8
38	A:A:D223	A:A:L45	4.07	No	Yes	0	9	8
39	A:A:I245	A:A:L45	2.85	Yes	Yes	0	7	8
40	A:A:I244	A:A:L46	2.85	Yes	Yes	1	8	8
41	A:A:F246	A:A:L46	2.44	Yes	Yes	1	9	8
42	A:A:I276	A:A:L46	2.85	No	Yes	0	8	8
43	A:A:G47	A:A:S51	3.71	No	Yes	0	9	9
44	A:A:D49	A:A:N50	4.04	No	No	17	8	9
45	A:A:D49	A:A:R265	7.15	No	Yes	17	8	9
46	A:A:D249	A:A:N50	8.08	No	No	0	8	9
47	A:A:N50	A:A:R265	10.85	No	Yes	17	9	9
48	A:A:K53	A:A:S51	3.06	No	Yes	16	9	9
49	A:A:S51	A:A:V247	3.23	Yes	Yes	16	9	7
50	A:A:K53	A:A:V247	3.04	No	Yes	16	9	7
51	A:A:I56	A:A:V247	4.61	No	Yes	0	7	7
52	A:A:F290	A:A:I56	2.51	Yes	No	0	9	7
53	A:A:N371	A:A:Q59	6.6	Yes	No	0	9	9
54	A:A:F212	A:A:M60	6.22	Yes	No	5	9	9
55	A:A:M221	A:A:M60	2.89	Yes	No	5	8	9
56	A:A:F208	A:A:S205	5.28	No	No	0	5	7
57	A:A:G206	A:A:Q227	4.93	No	Yes	1	8	9
58	A:A:G206	B:B:N119	5.09	No	No	1	8	9
59	A:A:F222	A:A:I207	2.51	Yes	Yes	1	7	9
60	A:A:F238	A:A:I207	2.51	Yes	Yes	1	9	9
61	A:A:I207	B:B:W99	3.52	Yes	Yes	1	9	9
62	A:A:I207	B:B:L117	2.85	Yes	Yes	1	9	9
63	A:A:F208	A:A:G225	3.01	No	No	0	5	9
64	A:A:E209	A:A:K211	12.15	No	No	1	9	4
65	A:A:E209	A:A:H220	11.08	No	No	1	9	7
66	A:A:E209	A:A:F222	8.16	No	Yes	1	9	7
67	A:A:M221	A:A:T210	4.52	Yes	No	0	8	7
68	A:A:H220	A:A:K211	13.1	No	No	1	7	4
69	A:A:F212	A:A:F219	12.86	Yes	Yes	5	9	8
70	A:A:F212	A:A:M221	2.49	Yes	Yes	5	9	8
71	A:A:N218	A:A:Q213	6.6	No	No	0	4	3
72	A:A:D215	A:A:V214	2.92	No	Yes	5	5	6
73	A:A:F219	A:A:V214	3.93	Yes	Yes	5	8	6
74	A:A:R373	A:A:V214	2.62	Yes	Yes	5	5	6
75	A:A:F376	A:A:V214	3.93	Yes	Yes	5	8	6
76	A:A:D215	A:A:R373	10.72	No	Yes	5	5	5
77	A:A:D215	A:A:F376	8.36	No	Yes	5	5	8
78	A:A:F219	A:A:V217	3.93	Yes	No	5	8	5
79	A:A:F376	A:A:V217	3.93	Yes	No	5	8	5
80	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
81	A:A:F222	A:A:H220	3.39	Yes	No	1	7	7
82	A:A:F222	B:B:W99	18.04	Yes	Yes	1	7	9
83	A:A:Q227	A:A:V224	4.3	Yes	No	1	9	9
84	A:A:V224	A:A:W234	12.26	No	No	1	9	9
85	A:A:Q227	A:A:W234	3.29	Yes	No	1	9	9
86	A:A:Q227	B:B:L117	7.99	Yes	Yes	1	9	9
87	A:A:Q227	B:B:N119	5.28	Yes	No	1	9	9
88	A:A:E230	A:A:R228	9.3	No	Yes	2	9	9
89	A:A:R228	B:B:T164	5.17	Yes	No	0	9	6
90	A:A:R228	B:B:D186	5.96	Yes	Yes	2	9	9
91	A:A:E230	A:A:R232	4.65	No	No	2	9	8
92	A:A:E230	B:B:D186	5.2	No	Yes	2	9	9
93	A:A:R231	A:A:W234	10	Yes	No	0	9	9
94	A:A:I235	A:A:R231	2.51	No	Yes	0	9	9
95	A:A:I276	A:A:R231	6.26	No	Yes	0	8	9
96	A:A:R232	B:B:C204	2.79	No	Yes	2	8	7
97	A:A:R232	B:B:D228	13.1	No	Yes	2	8	9
98	A:A:K233	B:B:Y145	3.58	Yes	Yes	2	9	8
99	A:A:K233	B:B:D186	2.77	Yes	Yes	2	9	9
100	A:A:K233	B:B:M188	4.32	Yes	No	2	9	8
101	A:A:K233	B:B:C204	4.85	Yes	Yes	2	9	7
102	A:A:K233	B:B:D228	8.3	Yes	Yes	2	9	9
103	A:A:K233	B:B:N230	4.2	Yes	No	2	9	9
104	A:A:K233	B:B:D246	4.15	Yes	No	2	9	9
105	A:A:I235	A:A:N279	2.83	No	No	0	9	8
106	A:A:Q236	A:A:W281	10.95	No	Yes	1	8	5
107	A:A:Q236	B:B:R314	4.67	No	Yes	1	8	8
108	A:A:C237	A:A:F238	2.79	Yes	Yes	1	8	9
109	A:A:C237	B:B:Y59	2.69	Yes	Yes	1	8	8
110	A:A:C237	B:B:Q75	3.05	Yes	Yes	1	8	9
111	A:A:C237	B:B:W99	2.61	Yes	Yes	1	8	9
112	A:A:F238	A:A:V241	3.93	Yes	No	0	9	9
113	A:A:F238	B:B:W99	8.02	Yes	Yes	1	9	9
114	A:A:F238	B:B:L117	2.44	Yes	Yes	1	9	9
115	A:A:D240	A:A:N239	5.39	No	No	1	6	8
116	A:A:N239	B:B:K57	4.2	No	Yes	1	8	9
117	A:A:N239	B:B:W332	6.78	No	Yes	1	8	9
118	A:A:D240	B:B:K57	9.68	No	Yes	1	6	9
119	A:A:I285	A:A:V241	4.61	No	No	0	7	9
120	A:A:A243	A:A:I288	3.25	No	Yes	0	8	9
121	A:A:I244	A:A:L282	2.85	Yes	Yes	1	8	9
122	A:A:I244	A:A:I285	5.89	Yes	No	1	8	7
123	A:A:F290	A:A:I245	2.51	Yes	Yes	5	9	7
124	A:A:I245	A:A:I375	2.94	Yes	No	5	7	9
125	A:A:F246	A:A:V248	2.62	Yes	No	0	9	7
126	A:A:F246	A:A:F273	3.22	Yes	Yes	1	9	9
127	A:A:F246	A:A:V287	2.62	Yes	No	1	9	6
128	A:A:F246	A:A:L289	3.65	Yes	Yes	1	9	9
129	A:A:N292	A:A:V247	4.43	Yes	Yes	0	9	7
130	A:A:F345	A:A:V248	6.55	Yes	No	0	8	7
131	A:A:D249	A:A:S251	5.89	No	No	0	8	9
132	A:A:D249	A:A:K293	12.44	No	Yes	0	8	9
133	A:A:Q294	A:A:S250	2.89	Yes	No	1	6	6
134	A:A:L297	A:A:S250	3	Yes	No	1	8	6
135	A:A:I341	A:A:S250	3.1	No	No	0	8	6
136	A:A:L296	A:A:S251	4.5	Yes	No	0	6	9
137	A:A:D252	A:A:N254	9.42	No	No	0	8	9
138	A:A:D252	A:A:R265	3.57	No	Yes	0	8	9
139	A:A:L297	A:A:Y253	3.52	Yes	Yes	1	8	8
140	A:A:K300	A:A:Y253	8.36	No	Yes	1	9	8
141	A:A:S306	A:A:Y253	5.09	No	Yes	1	7	8
142	A:A:I308	A:A:Y253	8.46	No	Yes	0	7	8
143	A:A:Y253	A:A:Y311	7.94	Yes	No	0	8	6
144	A:A:N254	A:A:Y311	9.3	No	No	0	9	6
145	A:A:E268	A:A:R265	9.3	No	Yes	0	9	9
146	A:A:F312	A:A:L266	4.87	No	No	0	8	8
147	A:A:I341	A:A:L266	2.85	No	No	0	8	8
148	A:A:L270	A:A:Q267	2.66	Yes	No	0	6	4
149	A:A:N271	A:A:Q267	6.6	No	No	0	5	4
150	A:A:E344	A:A:L270	2.65	No	Yes	0	5	6
151	A:A:F345	A:A:L270	7.31	Yes	Yes	0	8	6
152	A:A:I348	A:A:L270	4.28	No	Yes	0	4	6
153	A:A:F273	A:A:W277	3.01	Yes	Yes	1	9	6
154	A:A:F273	A:A:V287	5.24	Yes	No	1	9	6
155	A:A:F273	A:A:L289	2.44	Yes	Yes	1	9	9
156	A:A:F273	A:A:F345	6.43	Yes	Yes	1	9	8
157	A:A:F273	A:A:I348	3.77	Yes	No	0	9	4
158	A:A:F273	A:A:S349	2.64	Yes	Yes	1	9	7
159	A:A:C359	A:A:F273	4.19	Yes	Yes	1	5	9
160	A:A:K274	A:A:N278	5.6	No	No	0	5	8
161	A:A:I348	A:A:K274	2.91	No	No	0	4	5
162	A:A:I276	A:A:L282	2.85	No	Yes	0	8	9
163	A:A:N278	A:A:W277	3.39	No	Yes	0	8	6
164	A:A:V287	A:A:W277	4.9	No	Yes	1	6	6
165	A:A:S349	A:A:W277	6.18	Yes	Yes	1	7	6
166	A:A:H357	A:A:W277	23.27	No	Yes	0	7	6
167	A:A:C359	A:A:W277	2.61	Yes	Yes	1	5	6
168	A:A:N278	A:A:S352	2.98	No	No	0	8	5
169	A:A:L282	A:A:N279	12.36	Yes	No	0	9	8
170	A:A:R280	A:A:W281	6	No	Yes	0	5	5
171	A:A:W281	B:B:D290	5.58	Yes	Yes	1	5	6
172	A:A:W281	B:B:R314	9	Yes	Yes	1	5	8
173	A:A:W281	B:B:W332	3.75	Yes	Yes	1	5	9
174	A:A:I285	A:A:L282	2.85	No	Yes	1	7	9
175	A:A:R283	A:A:R356	9.6	No	No	0	3	2
176	A:A:S286	A:A:Y360	2.54	No	Yes	18	8	8
177	A:A:I382	A:A:S286	9.29	No	No	18	6	8
178	A:A:F290	A:A:I288	2.51	Yes	Yes	5	9	9
179	A:A:I288	A:A:I375	2.94	Yes	No	5	9	9
180	A:A:D378	A:A:I288	4.2	No	Yes	0	7	9
181	A:A:L289	A:A:L291	6.92	Yes	No	1	9	8
182	A:A:F345	A:A:L289	7.31	Yes	Yes	1	8	9
183	A:A:C359	A:A:L289	3.17	Yes	Yes	1	5	9
184	A:A:L289	A:A:P361	3.28	Yes	No	0	9	5
185	A:A:F290	A:A:T364	7.78	Yes	Yes	5	9	9
186	A:A:F290	A:A:N371	6.04	Yes	Yes	5	9	9
187	A:A:F290	A:A:I375	5.02	Yes	No	5	9	9
188	A:A:F345	A:A:L291	2.44	Yes	No	1	8	8
189	A:A:F363	A:A:L291	7.31	Yes	No	1	5	8
190	A:A:K293	A:A:N292	4.2	Yes	Yes	0	9	9
191	A:A:N292	A:A:T364	2.92	Yes	Yes	0	9	9
192	A:A:K293	A:A:L296	5.64	Yes	Yes	0	9	6
193	A:A:L297	A:A:Q294	2.66	Yes	Yes	1	8	6
194	A:A:K338	A:A:Q294	5.42	No	Yes	1	5	6
195	A:A:F363	A:A:Q294	14.05	Yes	Yes	1	5	6
196	A:A:D295	A:A:L296	2.71	No	Yes	0	9	6
197	A:A:L297	A:A:V301	2.98	Yes	No	0	8	7
198	A:A:K300	A:A:S306	6.12	No	No	1	9	7
199	A:A:V301	A:A:V334	3.21	No	No	0	7	4
200	A:A:E309	A:A:K307	2.7	No	No	0	4	6
201	A:A:D310	A:A:K307	8.3	No	No	0	3	6
202	A:A:F315	A:A:I308	5.02	Yes	No	0	6	7
203	A:A:E309	A:A:F315	7	No	Yes	0	4	6
204	A:A:D310	A:A:Y311	3.45	No	No	0	3	6
205	A:A:F312	A:A:F340	5.36	No	Yes	0	8	7
206	A:A:E314	A:A:R317	10.47	No	No	0	6	2
207	A:A:F315	A:A:R336	14.97	Yes	No	0	6	5
208	A:A:F315	A:A:F340	16.08	Yes	Yes	0	6	7
209	A:A:P321	A:A:Y318	4.17	Yes	Yes	0	5	6
210	A:A:R336	A:A:Y318	4.12	No	Yes	0	5	6
211	A:A:F340	A:A:Y318	4.13	Yes	Yes	0	7	6
212	A:A:K343	A:A:Y318	10.75	No	Yes	0	3	6
213	A:A:P321	A:A:T320	5.25	Yes	No	0	5	1
214	A:A:R336	A:A:T320	3.88	No	No	0	5	1
215	A:A:D323	A:A:P321	3.22	No	Yes	0	4	5
216	A:A:P321	A:A:Y339	5.56	Yes	Yes	0	5	3
217	A:A:E327	A:A:T325	5.64	Yes	No	0	4	2
218	A:A:P326	A:A:Y339	4.17	No	Yes	0	1	3
219	A:A:E327	A:A:E330	7.61	Yes	Yes	1	4	3
220	A:A:E327	A:A:T335	9.88	Yes	No	1	4	4
221	A:A:E330	A:A:V334	4.28	Yes	No	0	3	4
222	A:A:E330	A:A:T335	9.88	Yes	No	1	3	4
223	A:A:E330	A:A:K338	8.1	Yes	No	1	3	5
224	A:A:D331	A:A:P332	9.66	No	No	0	4	1
225	A:A:D331	A:A:R333	8.34	No	No	0	4	5
226	A:A:T335	A:A:Y339	2.5	No	Yes	0	4	3
227	A:A:F363	A:A:K338	9.93	Yes	No	1	5	5
228	A:A:R342	A:A:Y339	4.12	No	Yes	0	4	3
229	A:A:E344	A:A:F340	11.66	No	Yes	0	5	7
230	A:A:F345	A:A:I341	2.51	Yes	No	0	8	8
231	A:A:P361	A:A:R342	8.65	No	No	0	5	4
232	A:A:F363	A:A:R342	9.62	Yes	No	0	5	4
233	A:A:D347	A:A:K343	5.53	No	No	0	4	3
234	A:A:S349	A:A:T350	3.2	Yes	No	0	7	4
235	A:A:C359	A:A:S349	5.16	Yes	Yes	1	5	7
236	A:A:D354	A:A:R356	16.68	No	No	0	3	2
237	A:A:H357	A:A:R356	4.51	No	No	0	7	2
238	A:A:I358	A:A:Y360	8.46	No	Yes	0	4	8
239	A:A:D378	A:A:Y360	13.79	No	Yes	0	7	8
240	A:A:D381	A:A:Y360	5.75	No	Yes	0	8	8
241	A:A:I382	A:A:Y360	4.84	No	Yes	18	6	8
242	A:A:H362	A:A:R374	14.67	No	Yes	0	9	4
243	A:A:D378	A:A:H362	6.3	No	No	0	7	9
244	A:A:D368	A:A:T364	5.78	Yes	Yes	5	9	9
245	A:A:N371	A:A:T364	7.31	Yes	Yes	5	9	9
246	A:A:R374	A:A:T364	2.59	Yes	Yes	5	4	9
247	A:A:D368	A:A:E370	6.5	Yes	No	5	9	4
248	A:A:D368	A:A:N371	8.08	Yes	Yes	5	9	9
249	A:A:D368	A:A:R374	5.96	Yes	Yes	5	9	4
250	A:A:E370	A:A:R374	3.49	No	Yes	5	4	4
251	A:A:N371	A:A:R374	4.82	Yes	Yes	5	9	4
252	A:A:F376	A:A:R373	4.28	Yes	Yes	5	8	5
253	A:A:N377	A:A:R373	3.62	No	Yes	0	4	5
254	A:A:F376	A:A:K380	2.48	Yes	No	0	8	7
255	A:A:F376	R:R:I128	2.51	Yes	Yes	5	8	6
256	A:A:K380	R:R:P127	3.35	No	No	0	7	9
257	A:A:D381	A:A:Q385	3.92	No	No	0	8	5
258	A:A:I383	R:R:I128	2.94	No	Yes	0	8	6
259	A:A:I383	R:R:R131	2.51	No	Yes	0	8	6
260	A:A:L384	A:A:L388	4.15	No	No	0	6	8
261	A:A:L384	R:R:P127	4.93	No	No	0	6	9
262	A:A:Q385	R:R:I209	4.12	No	No	0	5	4
263	A:A:M386	A:A:R389	2.48	No	No	0	4	5
264	A:A:M386	R:R:R131	7.44	No	Yes	0	4	6
265	A:A:N387	R:R:S123	5.96	No	No	4	8	8
266	A:A:N387	R:R:Y130	5.81	No	Yes	4	8	7
267	A:A:N387	R:R:R131	7.23	No	Yes	0	8	6
268	A:A:L388	A:A:L393	2.77	No	No	0	8	8
269	A:A:L388	A:A:V394	7.45	No	No	0	8	8
270	A:A:E390	A:A:Y391	7.86	Yes	Yes	4	4	4
271	A:A:E390	R:R:N59	2.63	Yes	No	0	4	8
272	A:A:E390	R:R:Y130	8.98	Yes	Yes	4	4	7
273	A:A:E390	R:R:R131	4.65	Yes	Yes	0	4	6
274	A:A:Y391	R:R:F61	7.22	Yes	Yes	4	4	7
275	A:A:Y391	R:R:E119	3.37	Yes	No	0	4	9
276	A:A:Y391	R:R:R120	5.14	Yes	No	0	4	9
277	A:A:Y391	R:R:S123	5.09	Yes	No	4	4	8
278	A:A:Y391	R:R:Y130	11.91	Yes	Yes	4	4	7
279	A:A:N392	R:R:F61	3.62	No	Yes	0	7	7
280	A:A:N392	R:R:G276	5.09	No	No	0	7	8
281	A:A:L393	R:R:L214	6.92	No	Yes	0	8	7
282	A:A:L393	R:R:T217	2.95	No	Yes	0	8	7
283	B:B:D5	B:B:Q6	2.61	No	No	0	1	1
284	B:B:L7	G:G:A12	3.15	No	No	0	8	5
285	B:B:E10	B:B:L14	2.65	No	No	0	8	8
286	B:B:E10	G:G:V16	7.13	No	No	0	8	7
287	B:B:L14	G:G:L19	4.15	No	No	0	8	9
288	B:B:L14	G:G:K20	2.82	No	No	0	8	6
289	B:B:I18	B:B:R22	5.01	No	No	0	7	6
290	B:B:I18	G:G:A23	3.25	No	No	0	7	8
291	B:B:A21	G:G:R27	2.77	No	Yes	0	4	8
292	B:B:D258	B:B:R22	7.15	Yes	No	8	7	6
293	B:B:R22	G:G:R27	3.2	No	Yes	8	6	8
294	B:B:C25	B:B:Q259	4.58	No	No	0	3	6
295	B:B:C25	G:G:R27	2.79	No	Yes	0	3	8
296	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
297	B:B:D27	G:G:K29	8.3	No	No	0	8	4
298	B:B:D27	G:G:S31	4.42	No	No	0	8	9
299	B:B:A28	B:B:I33	3.25	No	No	0	4	3
300	B:B:S31	B:B:T29	3.2	No	No	0	1	3
301	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
302	B:B:L261	B:B:L30	2.77	No	No	0	5	5
303	B:B:L30	B:B:M262	5.65	No	Yes	0	5	4
304	B:B:L30	G:G:A34	4.73	No	No	0	5	6
305	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
306	B:B:I33	G:G:A34	6.5	No	No	0	3	6
307	B:B:I37	B:B:T34	3.04	Yes	No	12	2	5
308	B:B:L300	B:B:T34	4.42	Yes	No	12	6	5
309	B:B:T34	G:G:M38	9.03	No	No	12	5	4
310	B:B:I37	B:B:R283	3.76	Yes	Yes	12	2	9
311	B:B:I37	G:G:M38	4.37	Yes	No	12	2	4
312	B:B:I37	G:G:E42	2.73	Yes	No	0	2	1
313	B:B:I43	B:B:V40	6.14	No	Yes	0	3	3
314	B:B:R283	B:B:V40	6.54	Yes	Yes	12	9	3
315	B:B:V40	G:G:L51	2.98	Yes	Yes	12	3	6
316	B:B:I43	B:B:M45	2.92	No	No	0	3	4
317	B:B:I43	B:B:L284	4.28	No	Yes	0	3	5
318	B:B:L308	B:B:M45	4.24	No	No	0	7	4
319	B:B:M45	G:G:L50	4.24	No	No	0	4	9
320	B:B:R46	B:B:R48	8.53	No	No	0	5	7
321	B:B:K337	B:B:T47	6.01	Yes	No	10	6	3
322	B:B:T47	B:B:W339	9.7	No	Yes	10	3	9
323	B:B:N340	B:B:R48	6.03	No	No	6	9	7
324	B:B:R48	G:G:F61	3.21	No	Yes	6	7	8
325	B:B:R49	B:B:T87	2.59	No	No	0	7	5
326	B:B:I338	B:B:R49	2.51	No	No	6	5	7
327	B:B:R49	G:G:F61	4.28	No	Yes	6	7	8
328	B:B:R52	B:B:T50	9.06	No	No	0	7	3
329	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
330	B:B:L51	B:B:L70	2.77	Yes	No	6	9	5
331	B:B:L51	B:B:W82	20.5	Yes	Yes	6	9	9
332	B:B:L51	B:B:T87	2.95	Yes	No	0	9	5
333	B:B:L336	B:B:L51	6.92	Yes	Yes	6	7	9
334	B:B:I338	B:B:L51	4.28	No	Yes	6	5	9
335	B:B:F335	B:B:R52	7.48	No	No	0	4	7
336	B:B:H54	B:B:I58	10.61	Yes	No	0	9	9
337	B:B:H54	B:B:S72	4.18	Yes	No	6	9	9
338	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
339	B:B:H54	B:B:I80	9.28	Yes	No	6	9	8
340	B:B:H54	B:B:W82	3.17	Yes	Yes	6	9	9
341	B:B:H54	B:B:S334	2.79	Yes	No	0	9	4
342	B:B:D76	B:B:L55	10.86	Yes	No	0	9	6
343	B:B:A56	B:B:D76	4.63	No	Yes	0	7	9
344	B:B:K57	B:B:Y59	3.58	Yes	Yes	1	9	8
345	B:B:K57	B:B:Q75	13.56	Yes	Yes	1	9	9
346	B:B:K57	B:B:W332	15.08	Yes	Yes	1	9	9
347	B:B:I58	B:B:L336	2.85	No	Yes	0	9	7
348	B:B:Q75	B:B:Y59	9.02	Yes	Yes	1	9	8
349	B:B:M101	B:B:Y59	5.99	No	Yes	0	9	8
350	B:B:W332	B:B:Y59	4.82	Yes	Yes	1	9	8
351	B:B:A60	B:B:C103	3.61	No	No	0	7	8
352	B:B:C317	B:B:M61	9.73	No	No	0	7	6
353	B:B:A328	B:B:M61	3.22	No	No	0	5	6
354	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
355	B:B:H62	B:B:R150	14.67	No	No	0	6	6
356	B:B:L70	B:B:W63	4.56	No	Yes	0	5	7
357	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
358	B:B:T321	B:B:W63	9.7	Yes	Yes	0	7	7
359	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
360	B:B:G64	B:B:Y105	2.9	No	Yes	0	5	6
361	B:B:D66	B:B:R68	3.57	No	No	0	8	5
362	B:B:D66	B:B:L69	8.14	No	No	0	8	5
363	B:B:S67	B:B:T321	4.8	No	Yes	13	5	7
364	B:B:D322	B:B:S67	4.42	No	No	13	1	5
365	B:B:D323	B:B:S67	8.83	No	No	13	7	5
366	B:B:D83	B:B:R68	14.29	No	No	0	8	5
367	B:B:R68	B:B:Y85	22.64	No	Yes	0	5	4
368	B:B:L69	B:B:V90	2.98	No	No	0	5	5
369	B:B:L70	B:B:W82	5.69	No	Yes	6	5	9
370	B:B:L79	B:B:V71	2.98	Yes	Yes	11	7	8
371	B:B:I81	B:B:V71	3.07	Yes	Yes	11	7	8
372	B:B:V71	B:B:Y105	5.05	Yes	Yes	11	8	6
373	B:B:V112	B:B:V71	4.81	No	Yes	0	8	8
374	B:B:S72	B:B:W82	2.47	No	Yes	6	9	9
375	B:B:L336	B:B:S72	6.01	Yes	No	6	7	9
376	B:B:A73	B:B:C103	3.61	No	No	0	9	8
377	B:B:D76	B:B:S74	5.89	Yes	No	0	9	9
378	B:B:Q75	B:B:W99	7.67	Yes	Yes	1	9	9
379	B:B:D76	B:B:K78	8.3	Yes	No	0	9	8
380	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
381	B:B:I93	B:B:L79	4.28	Yes	Yes	11	7	7
382	B:B:L79	B:B:L95	4.15	Yes	Yes	11	7	8
383	B:B:C114	B:B:L79	6.35	No	Yes	11	8	7
384	B:B:I80	B:B:W82	14.09	No	Yes	6	8	9
385	B:B:H91	B:B:I81	7.95	Yes	Yes	0	5	7
386	B:B:I81	B:B:Y105	4.84	Yes	Yes	11	7	6
387	B:B:I81	B:B:L126	4.28	Yes	Yes	11	7	5
388	B:B:K89	B:B:W82	10.44	Yes	Yes	6	9	9
389	B:B:L336	B:B:W82	4.56	Yes	Yes	6	7	9
390	B:B:D83	B:B:T86	7.23	No	No	6	8	6
391	B:B:D83	B:B:N88	2.69	No	Yes	6	8	7
392	B:B:S84	B:B:Y85	2.54	No	Yes	6	5	4
393	B:B:S84	G:G:F61	5.28	No	Yes	6	5	8
394	B:B:Y85	G:G:P60	8.34	Yes	Yes	0	4	9
395	B:B:Y85	G:G:F61	8.25	Yes	Yes	6	4	8
396	B:B:N88	B:B:T86	10.24	Yes	No	6	7	6
397	B:B:H91	B:B:V90	5.54	Yes	No	0	5	5
398	B:B:H91	B:B:V133	4.15	Yes	Yes	0	5	4
399	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
400	B:B:I93	B:B:Y124	3.63	Yes	Yes	11	7	6
401	B:B:I93	B:B:V133	9.22	Yes	Yes	11	7	4
402	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
403	B:B:C114	B:B:L95	3.17	No	Yes	11	8	8
404	B:B:L95	B:B:Y124	5.86	Yes	Yes	11	8	6
405	B:B:R96	B:B:V135	5.23	No	No	0	6	4
406	B:B:E138	B:B:R96	8.14	No	No	0	6	6
407	B:B:S97	B:B:W99	2.47	No	Yes	0	8	9
408	B:B:D118	B:B:S97	11.78	No	No	0	9	8
409	B:B:S98	B:B:W99	6.18	No	Yes	0	8	9
410	B:B:L117	B:B:W99	5.69	Yes	Yes	1	9	9
411	B:B:L117	B:B:M101	4.24	Yes	No	0	9	9
412	B:B:M101	B:B:Y145	7.18	No	Yes	0	9	8
413	B:B:C149	B:B:T102	6.76	Yes	No	0	8	8
414	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
415	B:B:L126	B:B:Y105	3.52	Yes	Yes	11	5	6
416	B:B:A106	B:B:F151	5.55	No	Yes	0	6	9
417	B:B:F151	B:B:P107	4.33	Yes	No	0	9	6
418	B:B:N110	B:B:S108	7.45	Yes	No	2	4	6
419	B:B:D154	B:B:S108	8.83	No	No	2	6	6
420	B:B:N110	B:B:Y111	3.49	Yes	Yes	2	4	4
421	B:B:K127	B:B:N110	6.99	No	Yes	0	4	4
422	B:B:D154	B:B:N110	4.04	No	Yes	2	6	4
423	B:B:I123	B:B:Y111	3.63	Yes	Yes	2	6	4
424	B:B:N125	B:B:Y111	10.47	No	Yes	0	4	4
425	B:B:S136	B:B:Y111	2.54	No	Yes	2	4	4
426	B:B:D154	B:B:Y111	6.9	No	Yes	2	6	4
427	B:B:V112	B:B:Y124	3.79	No	Yes	0	8	6
428	B:B:L126	B:B:V112	2.98	Yes	No	0	5	8
429	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
430	B:B:C114	B:B:Y124	5.38	No	Yes	11	8	6
431	B:B:D118	B:B:I120	2.8	No	No	0	9	6
432	B:B:G144	B:B:N119	5.09	No	No	0	8	9
433	B:B:E138	B:B:I120	4.1	No	No	0	6	6
434	B:B:C121	B:B:C149	3.64	No	Yes	0	8	8
435	B:B:C121	B:B:T159	3.38	No	Yes	0	8	9
436	B:B:S122	B:B:Y124	3.82	No	Yes	11	8	6
437	B:B:S122	B:B:V135	3.23	No	No	11	8	4
438	B:B:E138	B:B:S122	5.75	No	No	0	6	8
439	B:B:I123	B:B:S136	3.1	Yes	No	2	6	4
440	B:B:I123	B:B:R137	2.51	Yes	No	2	6	5
441	B:B:I123	B:B:L139	2.85	Yes	Yes	2	6	9
442	B:B:F151	B:B:I123	3.77	Yes	Yes	2	9	6
443	B:B:I123	B:B:I171	5.89	Yes	Yes	2	6	6
444	B:B:V133	B:B:Y124	3.79	Yes	Yes	11	4	6
445	B:B:V135	B:B:Y124	6.31	No	Yes	11	4	6
446	B:B:N125	B:B:T128	8.77	No	No	0	4	3
447	B:B:L126	B:B:V133	4.47	Yes	Yes	11	5	4
448	B:B:R134	B:B:T128	3.88	No	No	0	3	3
449	B:B:E130	B:B:N132	3.94	No	No	0	3	3
450	B:B:L139	B:B:R137	3.64	Yes	No	2	9	5
451	B:B:I171	B:B:R137	3.76	Yes	No	2	6	5
452	B:B:L139	B:B:W169	17.08	Yes	Yes	2	9	8
453	B:B:H142	B:B:T159	5.48	Yes	Yes	2	9	9
454	B:B:H142	B:B:S161	13.95	Yes	No	2	9	9
455	B:B:D163	B:B:H142	6.3	Yes	Yes	2	9	9
456	B:B:H142	B:B:T165	4.11	Yes	No	2	9	7
457	B:B:A167	B:B:H142	2.93	No	Yes	2	4	9
458	B:B:H142	B:B:W169	4.23	Yes	Yes	2	9	8
459	B:B:H142	B:B:Q176	2.47	Yes	Yes	2	9	4
460	B:B:D163	B:B:T143	5.78	Yes	No	0	9	5
461	B:B:S147	B:B:Y145	2.54	No	Yes	0	9	8
462	B:B:G162	B:B:Y145	5.79	No	Yes	2	9	8
463	B:B:D186	B:B:Y145	10.34	Yes	Yes	2	9	8
464	B:B:L146	B:B:T159	4.42	No	Yes	0	7	9
465	B:B:S147	B:B:S160	3.26	No	Yes	0	9	6
466	B:B:C148	B:B:L190	4.76	No	Yes	0	6	5
467	B:B:C149	B:B:I157	3.27	Yes	No	0	8	7
468	B:B:L192	B:B:R150	3.64	No	No	0	5	6
469	B:B:F151	B:B:I157	5.02	Yes	No	2	9	7
470	B:B:F151	B:B:I171	3.77	Yes	Yes	2	9	6
471	B:B:D153	B:B:L152	2.71	No	Yes	7	5	3
472	B:B:L152	B:B:Q156	7.99	Yes	No	7	3	5
473	B:B:L152	B:B:V158	4.47	Yes	No	0	3	5
474	B:B:L152	B:B:L192	4.15	Yes	No	0	3	5
475	B:B:L152	B:B:T196	4.42	Yes	No	0	3	1
476	B:B:D153	B:B:Q156	6.53	No	No	7	5	5
477	B:B:D170	B:B:N155	6.73	Yes	No	7	9	3
478	B:B:E172	B:B:N155	3.94	No	No	7	6	3
479	B:B:L168	B:B:Q156	2.66	Yes	No	7	6	5
480	B:B:I157	B:B:I171	4.42	No	Yes	2	7	6
481	B:B:F199	B:B:V158	3.93	Yes	No	0	9	5
482	B:B:T159	B:B:W169	10.92	Yes	Yes	2	9	8
483	B:B:C166	B:B:S160	3.44	Yes	Yes	0	8	6
484	B:B:S160	B:B:V187	6.46	Yes	Yes	0	6	9
485	B:B:L190	B:B:S160	4.5	Yes	Yes	0	5	6
486	B:B:G162	B:B:S161	3.71	No	No	2	9	9
487	B:B:D163	B:B:S161	5.89	Yes	No	2	9	9
488	B:B:D186	B:B:G162	5.03	Yes	No	2	9	9
489	B:B:D163	B:B:T165	10.12	Yes	No	2	9	7
490	B:B:C166	B:B:F180	4.19	Yes	Yes	7	8	7
491	B:B:C166	B:B:F199	2.79	Yes	Yes	7	8	9
492	B:B:C166	B:B:S201	3.44	Yes	Yes	0	8	9
493	B:B:A167	B:B:W169	5.19	No	Yes	2	4	8
494	B:B:A167	B:B:Q176	6.06	No	Yes	2	4	4
495	B:B:L168	B:B:T177	4.42	Yes	No	7	6	4
496	B:B:L168	B:B:T178	5.9	Yes	No	7	6	4
497	B:B:F180	B:B:L168	2.44	Yes	Yes	7	7	6
498	B:B:L168	B:B:V213	2.98	Yes	No	0	6	4
499	B:B:Q176	B:B:W169	16.43	Yes	Yes	2	4	8
500	B:B:D170	B:B:E172	2.6	Yes	No	7	9	6
501	B:B:D170	B:B:T173	5.78	Yes	No	0	9	5
502	B:B:D170	B:B:T177	4.34	Yes	No	7	9	4
503	B:B:Q175	B:B:T173	9.92	No	No	0	4	5
504	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
505	B:B:T177	B:B:T178	4.71	No	No	7	4	4
506	B:B:F180	B:B:T178	6.49	Yes	No	7	7	4
507	B:B:F180	B:B:F199	9.65	Yes	Yes	7	7	9
508	B:B:F180	B:B:W211	14.03	Yes	Yes	7	7	8
509	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
510	B:B:H183	B:B:V187	6.92	Yes	Yes	7	9	9
511	B:B:A203	B:B:H183	8.78	No	Yes	7	8	9
512	B:B:D205	B:B:H183	7.56	Yes	Yes	7	9	9
513	B:B:H183	B:B:S207	2.79	Yes	No	7	9	5
514	B:B:H183	B:B:K209	15.72	Yes	Yes	7	9	6
515	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
516	B:B:C204	B:B:D186	6.22	Yes	Yes	2	7	9
517	B:B:S201	B:B:V187	3.23	Yes	Yes	0	9	9
518	B:B:A203	B:B:V187	5.09	No	Yes	7	8	9
519	B:B:C204	B:B:M188	3.24	Yes	No	2	7	8
520	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
521	B:B:F199	B:B:L190	4.87	Yes	Yes	0	9	5
522	B:B:L190	B:B:S201	3	Yes	Yes	0	5	9
523	B:B:F234	B:B:S191	5.28	Yes	No	0	5	8
524	B:B:A193	B:B:D195	4.63	No	No	0	4	5
525	B:B:A193	B:B:F234	2.77	No	Yes	0	4	5
526	B:B:G238	B:B:P194	4.06	No	No	0	7	4
527	B:B:D195	B:B:R197	4.76	No	No	0	5	5
528	B:B:R197	B:B:R214	7.46	No	No	0	5	9
529	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
530	B:B:D212	B:B:L198	5.43	Yes	No	0	9	3
531	B:B:F199	B:B:W211	11.02	Yes	Yes	7	9	8
532	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
533	B:B:L210	B:B:V200	2.98	Yes	Yes	0	5	6
534	B:B:I232	B:B:V200	4.61	Yes	Yes	8	8	6
535	B:B:F234	B:B:V200	6.55	Yes	Yes	0	5	6
536	B:B:F241	B:B:V200	7.87	Yes	Yes	8	6	6
537	B:B:S201	B:B:W211	2.47	Yes	Yes	0	9	8
538	B:B:A203	B:B:D205	3.09	No	Yes	7	8	9
539	B:B:C204	B:B:D228	4.67	Yes	Yes	2	7	9
540	B:B:D205	B:B:S207	8.83	Yes	No	7	9	5
541	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
542	B:B:K209	B:B:W211	6.96	Yes	Yes	7	6	8
543	B:B:C218	B:B:K209	8.08	No	Yes	7	5	6
544	B:B:K209	B:B:T221	13.51	Yes	No	0	6	7
545	B:B:L210	B:B:R219	3.64	Yes	No	0	5	5
546	B:B:L210	B:B:Q220	6.65	Yes	Yes	0	5	7
547	B:B:L210	B:B:L255	5.54	Yes	No	0	5	6
548	B:B:C218	B:B:W211	9.14	No	Yes	7	5	8
549	B:B:D212	B:B:E215	7.8	Yes	No	14	9	3
550	B:B:D212	B:B:M217	5.54	Yes	No	14	9	3
551	B:B:D212	B:B:R219	9.53	Yes	No	14	9	5
552	B:B:E215	B:B:M217	2.71	No	No	14	3	3
553	B:B:M217	B:B:R219	14.89	No	No	14	3	5
554	B:B:C218	G:G:Q18	3.05	No	No	0	5	9
555	B:B:F222	B:B:Q220	7.03	Yes	Yes	8	8	7
556	B:B:D258	B:B:Q220	10.44	Yes	Yes	8	7	7
557	B:B:Q220	G:G:I25	4.12	Yes	No	8	7	2
558	B:B:T221	G:G:E22	5.64	No	No	0	7	9
559	B:B:F222	B:B:F241	9.65	Yes	Yes	8	8	6
560	B:B:F222	B:B:F253	5.36	Yes	Yes	8	8	6
561	B:B:D258	B:B:F222	4.78	Yes	Yes	8	7	8
562	B:B:F253	B:B:G224	3.01	Yes	No	0	6	6
563	B:B:H225	B:B:I229	3.98	Yes	No	8	9	7
564	B:B:H225	B:B:T243	6.85	Yes	Yes	8	9	8
565	B:B:H225	B:B:S245	15.34	Yes	No	8	9	9
566	B:B:D247	B:B:H225	2.52	Yes	Yes	8	9	9
567	B:B:H225	B:B:T249	2.74	Yes	Yes	8	9	6
568	B:B:H225	B:B:R251	19.18	Yes	Yes	8	9	8
569	B:B:D247	B:B:E226	18.19	Yes	No	0	9	3
570	B:B:D228	B:B:S227	5.89	Yes	No	0	9	6
571	B:B:D246	B:B:S227	2.94	No	No	0	9	6
572	B:B:I229	B:B:S245	6.19	No	No	8	7	9
573	B:B:D246	B:B:N230	12.12	No	No	2	9	9
574	B:B:A231	B:B:V276	3.39	No	No	0	5	6
575	B:B:F241	B:B:I232	5.02	Yes	Yes	8	6	8
576	B:B:I232	B:B:T243	3.04	Yes	Yes	8	8	8
577	B:B:C233	B:B:F278	2.79	No	Yes	0	3	7
578	B:B:F234	B:B:G238	3.01	Yes	No	0	5	7
579	B:B:F234	B:B:L255	2.44	Yes	No	0	5	6
580	B:B:F235	B:B:P236	10.11	Yes	Yes	9	6	7
581	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
582	B:B:F235	B:B:F278	7.5	Yes	Yes	9	6	7
583	B:B:F235	B:B:G282	3.01	Yes	No	9	6	9
584	B:B:F235	G:G:L37	2.44	Yes	No	0	6	7
585	B:B:F278	B:B:P236	4.33	Yes	Yes	9	7	7
586	B:B:G282	B:B:P236	4.06	No	Yes	9	9	7
587	B:B:P236	G:G:Y40	4.17	Yes	No	0	7	6
588	B:B:N237	B:B:N239	10.9	No	No	0	5	2
589	B:B:N237	G:G:Y40	4.65	No	No	0	5	6
590	B:B:F241	B:B:T243	2.59	Yes	Yes	8	6	8
591	B:B:F241	B:B:F253	12.86	Yes	Yes	8	6	6
592	B:B:F241	B:B:L255	2.44	Yes	No	0	6	6
593	B:B:A242	B:B:F278	2.77	No	Yes	9	4	7
594	B:B:A242	B:B:L285	3.15	No	Yes	9	4	6
595	B:B:F253	B:B:T243	7.78	Yes	Yes	8	6	8
596	B:B:G244	B:B:I273	3.53	No	No	0	5	6
597	B:B:D247	B:B:T249	13.01	Yes	Yes	8	9	6
598	B:B:D247	B:B:R251	4.76	Yes	Yes	8	9	8
599	B:B:R251	B:B:T249	6.47	Yes	Yes	8	8	6
600	B:B:T249	B:B:T263	3.14	Yes	Yes	8	6	1
601	B:B:S265	B:B:T249	4.8	No	Yes	8	2	6
602	B:B:C250	B:B:Y264	2.69	No	Yes	0	8	5
603	B:B:C250	B:B:I273	6.55	No	No	0	8	6
604	B:B:F253	B:B:R251	3.21	Yes	Yes	8	6	8
605	B:B:E260	B:B:R251	11.63	No	Yes	8	6	8
606	B:B:R251	B:B:T263	3.88	Yes	Yes	8	8	1
607	B:B:L252	B:B:L261	5.54	No	No	0	7	5
608	B:B:L252	B:B:Y264	7.03	No	Yes	0	7	5
609	B:B:F278	B:B:L252	2.44	Yes	No	0	7	7
610	B:B:E260	B:B:F253	4.66	No	Yes	8	6	6
611	B:B:D254	B:B:R256	3.57	Yes	No	0	9	9
612	B:B:A257	B:B:D254	4.63	No	Yes	0	7	9
613	B:B:D254	B:B:L261	4.07	Yes	No	0	9	5
614	B:B:D254	G:G:A33	3.09	Yes	No	0	9	7
615	B:B:R256	G:G:I28	10.02	No	No	0	9	4
616	B:B:R256	G:G:D36	7.15	No	No	0	9	5
617	B:B:D258	G:G:I25	2.8	Yes	No	8	7	2
618	B:B:D258	G:G:R27	4.76	Yes	Yes	8	7	8
619	B:B:Q259	G:G:V30	2.87	No	No	0	6	8
620	B:B:E260	B:B:T263	2.82	No	Yes	8	6	1
621	B:B:M262	B:B:Y264	9.58	Yes	Yes	9	4	5
622	B:B:A302	B:B:M262	4.83	No	Yes	9	2	4
623	B:B:S265	B:B:T263	3.2	No	Yes	8	2	1
624	B:B:L285	B:B:Y264	3.52	Yes	Yes	9	6	5
625	B:B:W297	B:B:Y264	4.82	Yes	Yes	9	8	5
626	B:B:A302	B:B:Y264	2.67	No	Yes	9	2	5
627	B:B:H266	B:B:N268	5.1	No	No	0	4	4
628	B:B:H266	B:B:I269	2.65	No	No	9	4	4
629	B:B:H266	B:B:R304	4.51	No	Yes	9	4	5
630	B:B:I269	B:B:Y289	7.25	No	Yes	9	4	7
631	B:B:I269	B:B:R304	2.51	No	Yes	9	4	5
632	B:B:C271	B:B:Y289	2.69	No	Yes	9	5	7
633	B:B:C271	B:B:D291	7.78	No	No	9	5	8
634	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
635	B:B:I273	B:B:Y289	9.67	No	Yes	0	6	7
636	B:B:D290	B:B:T274	4.34	Yes	No	1	6	8
637	B:B:R314	B:B:T274	6.47	Yes	No	1	8	8
638	B:B:L318	B:B:S277	3	Yes	No	0	6	5
639	B:B:G319	B:B:S277	3.71	No	No	0	5	5
640	B:B:F278	B:B:L285	7.31	Yes	Yes	9	7	6
641	B:B:L284	B:B:S279	3	Yes	Yes	0	5	9
642	B:B:S279	G:G:D48	4.42	Yes	No	0	9	9
643	B:B:S279	G:G:L50	3	Yes	No	0	9	9
644	B:B:K280	G:G:E47	2.7	No	No	0	1	3
645	B:B:S281	G:G:D48	8.83	No	No	0	9	9
646	B:B:D298	B:B:R283	14.29	No	Yes	12	9	9
647	B:B:L300	B:B:R283	6.07	Yes	Yes	12	6	9
648	B:B:R283	G:G:L51	4.86	Yes	Yes	12	9	6
649	B:B:L284	B:B:V296	4.47	Yes	No	0	5	5
650	B:B:L284	G:G:L51	2.77	Yes	Yes	0	5	6
651	B:B:L286	B:B:V296	2.98	Yes	No	0	7	5
652	B:B:L286	B:B:L318	2.77	Yes	Yes	10	7	6
653	B:B:L286	B:B:V320	2.98	Yes	No	10	7	7
654	B:B:L286	B:B:V327	4.47	Yes	No	10	7	6
655	B:B:G288	B:B:Y289	2.9	No	Yes	0	7	7
656	B:B:C294	B:B:G288	3.92	Yes	No	0	5	7
657	B:B:D291	B:B:Y289	3.45	No	Yes	9	8	7
658	B:B:N295	B:B:Y289	9.3	Yes	Yes	9	6	7
659	B:B:W297	B:B:Y289	5.79	Yes	Yes	9	8	7
660	B:B:D290	B:B:R314	17.87	Yes	Yes	1	6	8
661	B:B:D291	B:B:N293	8.08	No	No	0	8	5
662	B:B:N293	B:B:V307	2.96	No	No	0	5	3
663	B:B:A309	B:B:N293	3.13	No	No	0	3	5
664	B:B:C294	B:B:V315	5.12	Yes	No	10	5	7
665	B:B:C294	B:B:L318	3.17	Yes	Yes	10	5	6
666	B:B:C294	B:B:T329	5.07	Yes	Yes	10	5	8
667	B:B:N295	B:B:W297	3.39	Yes	Yes	9	6	8
668	B:B:N295	B:B:R304	10.85	Yes	Yes	9	6	5
669	B:B:N295	B:B:V307	4.43	Yes	No	9	6	3
670	B:B:R304	B:B:W297	6	Yes	Yes	9	5	8
671	B:B:D298	B:B:K301	5.53	No	Yes	12	9	5
672	B:B:D298	B:B:D303	7.98	No	No	12	9	2
673	B:B:L300	G:G:M38	4.24	Yes	No	12	6	4
674	B:B:L300	G:G:C41	4.76	Yes	No	0	6	7
675	B:B:D303	B:B:K301	6.91	No	Yes	12	2	5
676	B:B:R304	B:B:V307	2.62	Yes	No	9	5	3
677	B:B:L308	B:B:W339	14.81	No	Yes	0	7	9
678	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
679	B:B:H311	B:B:V315	4.15	Yes	No	10	9	7
680	B:B:H311	B:B:T329	5.48	Yes	Yes	10	9	8
681	B:B:H311	B:B:S331	16.74	Yes	No	10	9	9
682	B:B:D333	B:B:H311	6.3	Yes	Yes	10	9	9
683	B:B:H311	B:B:K337	7.86	Yes	Yes	10	9	6
684	B:B:D312	B:B:D333	11.98	No	Yes	0	5	9
685	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
686	B:B:D333	B:B:N313	4.04	Yes	No	0	9	7
687	B:B:R314	B:B:W332	16.99	Yes	Yes	1	8	9
688	B:B:S331	B:B:V315	3.23	No	No	10	9	7
689	B:B:S316	B:B:W332	7.41	No	Yes	0	9	9
690	B:B:L318	B:B:T329	4.42	Yes	Yes	10	6	8
691	B:B:V320	B:B:V327	4.81	No	No	10	7	6
692	B:B:D322	B:B:T321	2.89	No	Yes	13	1	7
693	B:B:D323	B:B:T321	4.34	No	Yes	13	7	7
694	B:B:D323	B:B:M325	9.7	No	Yes	0	7	5
695	B:B:M325	G:G:P49	6.71	Yes	No	0	5	7
696	B:B:M325	G:G:P60	5.03	Yes	Yes	0	5	9
697	B:B:M325	G:G:F61	2.49	Yes	Yes	0	5	8
698	B:B:A326	G:G:F61	5.55	No	Yes	0	7	8
699	B:B:V327	G:G:L50	2.98	No	No	0	6	9
700	B:B:T329	B:B:W339	7.28	Yes	Yes	10	8	9
701	B:B:D333	B:B:S331	5.89	Yes	No	10	9	9
702	B:B:D333	B:B:F335	5.97	Yes	No	0	9	4
703	B:B:F335	R:R:R55	4.28	No	No	0	4	6
704	B:B:K337	B:B:W339	5.8	Yes	Yes	10	6	9
705	B:B:I338	G:G:F61	5.02	No	Yes	6	5	8
706	B:B:N340	G:G:N59	13.62	No	No	0	9	9
707	B:B:N340	G:G:F61	3.62	No	Yes	6	9	8
708	G:G:L15	G:G:L19	4.15	No	No	0	2	9
709	G:G:I25	G:G:R27	10.02	No	Yes	8	2	8
710	G:G:I28	G:G:K32	10.18	No	No	0	4	5
711	G:G:H44	G:G:Y40	9.8	No	No	0	6	6
712	G:G:D48	G:G:L51	9.5	No	Yes	0	9	6
713	G:G:P49	G:G:V54	5.3	No	Yes	0	7	6
714	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
715	G:G:P55	G:G:V54	3.53	No	Yes	0	5	6
716	G:G:E58	G:G:V54	2.85	No	Yes	0	5	6
717	G:G:N59	G:G:V54	5.91	No	Yes	0	9	6
718	G:G:E58	G:G:P60	3.14	No	Yes	0	5	9
719	G:G:N59	G:G:P60	4.89	No	Yes	0	9	9
720	R:R:L28	R:R:Q26	3.99	No	No	0	4	1
721	R:R:L30	R:R:T27	10.32	No	No	0	5	4
722	R:R:L28	R:R:T31	5.9	No	No	20	4	4
723	R:R:F87	R:R:L28	2.44	Yes	No	20	4	4
724	R:R:L33	R:R:S29	3	No	No	0	6	4
725	R:R:F87	R:R:T31	3.89	Yes	No	20	4	4
726	R:R:R79	R:R:T34	2.59	Yes	No	0	6	5
727	R:R:F259	R:R:T34	2.59	No	No	0	5	5
728	R:R:C35	R:R:S83	5.16	No	No	0	5	6
729	R:R:C35	R:R:F87	2.79	No	Yes	0	5	4
730	R:R:S266	R:R:V37	3.23	No	No	0	7	7
731	R:R:L42	R:R:S38	3	Yes	No	15	7	5
732	R:R:L76	R:R:S38	4.5	Yes	No	15	7	5
733	R:R:L80	R:R:S38	7.51	Yes	No	15	7	5
734	R:R:L39	R:R:L80	4.15	No	Yes	0	5	7
735	R:R:G41	R:R:S266	3.71	No	No	0	9	7
736	R:R:F73	R:R:L42	4.87	No	Yes	0	7	7
737	R:R:L42	R:R:L76	4.15	Yes	Yes	15	7	7
738	R:R:L42	R:R:L80	2.77	Yes	Yes	15	7	7
739	R:R:D72	R:R:N45	4.04	Yes	No	0	9	9
740	R:R:N45	R:R:P269	11.4	No	No	0	9	9
741	R:R:L51	R:R:V47	2.98	No	No	0	7	6
742	R:R:F273	R:R:V48	6.55	Yes	No	0	7	9
743	R:R:L49	R:R:L66	4.15	No	No	0	7	7
744	R:R:L51	R:R:W50	5.69	No	No	0	7	5
745	R:R:F273	R:R:L51	4.87	Yes	No	0	7	7
746	R:R:L52	R:R:M56	5.65	No	No	21	7	6
747	R:R:F273	R:R:L52	12.18	Yes	No	21	7	7
748	R:R:M56	R:R:R57	9.93	No	No	0	6	6
749	R:R:F273	R:R:M56	2.49	Yes	No	21	7	6
750	R:R:R57	R:R:S62	9.22	No	No	0	6	7
751	R:R:R57	R:R:S277	6.59	No	No	0	6	6
752	R:R:A60	R:R:Y64	2.67	No	Yes	4	7	7
753	R:R:A60	R:R:R134	4.15	No	Yes	4	7	9
754	R:R:A60	R:R:S139	3.42	No	Yes	4	7	9
755	R:R:F61	R:R:I65	8.79	Yes	No	4	7	8
756	R:R:F61	R:R:V116	2.62	Yes	No	0	7	8
757	R:R:F61	R:R:Y272	6.19	Yes	Yes	4	7	9
758	R:R:I63	R:R:S139	7.74	No	Yes	0	7	9
759	R:R:A115	R:R:Y64	4	No	Yes	0	7	7
760	R:R:V116	R:R:Y64	3.79	No	Yes	0	8	7
761	R:R:E119	R:R:Y64	12.35	No	Yes	0	9	7
762	R:R:S139	R:R:Y64	7.63	Yes	Yes	4	9	7
763	R:R:V142	R:R:Y64	3.79	No	Yes	0	6	7
764	R:R:C143	R:R:Y64	2.69	No	Yes	0	7	7
765	R:R:I65	R:R:Y272	6.04	No	Yes	4	8	9
766	R:R:F112	R:R:N67	6.04	Yes	No	4	7	9
767	R:R:C143	R:R:N67	6.3	No	No	0	7	9
768	R:R:N67	R:R:W147	3.39	No	Yes	4	9	9
769	R:R:D72	R:R:L68	5.43	Yes	Yes	4	9	9
770	R:R:F112	R:R:L68	3.65	Yes	Yes	4	7	9
771	R:R:L113	R:R:L68	5.54	Yes	Yes	4	8	9
772	R:R:L68	R:R:N268	9.61	Yes	Yes	4	9	9
773	R:R:A71	R:R:F112	2.77	No	Yes	4	9	7
774	R:R:A71	R:R:W147	3.89	No	Yes	4	9	9
775	R:R:D72	R:R:S265	5.89	Yes	No	0	9	9
776	R:R:D72	R:R:N268	9.42	Yes	Yes	4	9	9
777	R:R:L74	R:R:S105	3	No	No	0	7	8
778	R:R:F75	R:R:R79	6.41	Yes	Yes	3	6	6
779	R:R:F75	R:R:M102	3.73	Yes	No	3	6	4
780	R:R:F75	R:R:S105	5.28	Yes	No	0	6	8
781	R:R:F75	R:R:Y106	8.25	Yes	Yes	3	6	7
782	R:R:F75	R:R:S261	2.64	Yes	No	3	6	7
783	R:R:F75	R:R:S265	7.93	Yes	No	0	6	9
784	R:R:L76	R:R:S265	4.5	Yes	No	0	7	9
785	R:R:I81	R:R:S77	3.1	No	No	0	5	5
786	R:R:M102	R:R:R79	11.17	No	Yes	3	4	6
787	R:R:F232	R:R:R79	4.28	Yes	Yes	3	5	6
788	R:R:I258	R:R:R79	12.53	No	Yes	3	4	6
789	R:R:L80	R:R:L84	4.15	Yes	No	0	7	5
790	R:R:I81	R:R:L98	5.71	No	No	0	5	4
791	R:R:S86	R:R:Y82	3.82	No	No	0	2	3
792	R:R:S95	R:R:Y82	2.54	No	No	0	7	3
793	R:R:F87	R:R:L84	2.44	Yes	No	0	4	5
794	R:R:L85	R:R:S89	3	No	No	0	4	4
795	R:R:I94	R:R:L85	2.85	No	No	0	5	4
796	R:R:F87	R:R:I88	2.51	Yes	No	0	4	3
797	R:R:I94	R:R:P91	6.77	No	No	0	5	7
798	R:R:K96	R:R:W158	8.12	No	Yes	3	5	4
799	L:L:?1	R:R:K96	17.22	Yes	No	3	0	5
800	R:R:P100	R:R:Y99	5.56	No	Yes	0	4	3
801	R:R:M103	R:R:Y99	7.18	No	Yes	3	2	3
802	R:R:E157	R:R:Y99	10.1	Yes	Yes	3	4	3
803	R:R:F236	R:R:Y99	5.16	Yes	Yes	3	4	3
804	L:L:?1	R:R:Y99	31.69	Yes	Yes	3	0	3
805	R:R:M103	R:R:R153	2.48	No	Yes	3	2	4
806	R:R:F237	R:R:M103	2.49	Yes	No	3	5	2
807	R:R:F104	R:R:W147	6.01	Yes	Yes	0	5	9
808	R:R:F104	R:R:S150	7.93	Yes	No	0	5	8
809	R:R:F104	R:R:L151	2.44	Yes	No	0	5	4
810	R:R:F104	R:R:S154	2.64	Yes	No	0	5	6
811	R:R:F107	R:R:Y106	5.16	Yes	Yes	3	6	7
812	R:R:L110	R:R:Y106	5.86	No	Yes	0	7	7
813	R:R:F232	R:R:Y106	8.25	Yes	Yes	3	5	7
814	R:R:G233	R:R:Y106	4.35	No	Yes	0	7	7
815	R:R:S261	R:R:Y106	6.36	No	Yes	3	7	7
816	R:R:F107	R:R:R153	12.83	Yes	Yes	3	6	4
817	R:R:F107	R:R:T180	2.59	Yes	No	3	6	5
818	R:R:F107	R:R:W183	4.01	Yes	Yes	3	6	6
819	R:R:A108	R:R:W147	3.89	No	Yes	0	7	9
820	R:R:A108	R:R:S150	3.42	No	No	0	7	8
821	R:R:F112	R:R:G109	3.01	Yes	No	0	7	9
822	R:R:F225	R:R:L110	2.44	Yes	No	0	8	7
823	R:R:L146	R:R:S111	6.01	No	No	0	7	6
824	R:R:S111	R:R:W183	3.71	No	Yes	3	6	6
825	R:R:L187	R:R:S111	3	No	No	3	9	6
826	R:R:F112	R:R:L146	6.09	Yes	No	0	7	7
827	R:R:F112	R:R:W147	11.02	Yes	Yes	4	7	9
828	R:R:F225	R:R:L113	3.65	Yes	Yes	4	8	8
829	R:R:L113	R:R:N268	12.36	Yes	Yes	4	8	9
830	R:R:L113	R:R:Y272	3.52	Yes	Yes	4	8	9
831	R:R:L187	R:R:S114	3	No	No	0	9	8
832	R:R:L191	R:R:S117	6.01	No	No	0	8	9
833	R:R:S194	R:R:T118	6.4	No	No	0	8	7
834	R:R:E119	R:R:R134	10.47	No	Yes	0	9	9
835	R:R:R120	R:R:T217	2.59	No	Yes	0	9	7
836	R:R:R120	R:R:T221	3.88	No	No	0	9	8
837	R:R:C121	R:R:L125	3.17	No	No	22	8	7
838	R:R:C121	R:R:S194	3.44	No	No	0	8	8
839	R:R:C121	R:R:V197	3.42	No	No	22	8	4
840	R:R:L122	R:R:W126	4.56	No	No	0	6	6
841	R:R:S123	R:R:Y130	12.72	No	Yes	4	8	7
842	R:R:L198	R:R:V124	5.96	No	No	0	8	8
843	R:R:I202	R:R:V124	3.07	No	No	0	6	8
844	R:R:L125	R:R:V197	2.98	No	No	22	7	4
845	R:R:L125	R:R:R201	6.07	No	No	0	7	6
846	R:R:C132	R:R:I128	3.27	No	Yes	5	6	6
847	R:R:H133	R:R:I128	2.65	No	Yes	5	5	6
848	R:R:R134	R:R:W129	3	Yes	No	0	9	5
849	R:R:R134	R:R:Y130	7.2	Yes	Yes	4	9	7
850	R:R:C132	R:R:H133	4.42	No	No	5	6	5
851	R:R:P135	R:R:R134	2.88	No	Yes	4	7	9
852	R:R:L138	R:R:R134	3.64	No	Yes	4	4	9
853	R:R:R134	R:R:S139	2.64	Yes	Yes	4	9	9
854	R:R:L138	R:R:P135	6.57	No	No	4	4	7
855	R:R:E157	R:R:R153	11.63	Yes	Yes	3	4	4
856	R:R:R153	R:R:T180	10.35	Yes	No	3	4	5
857	R:R:F237	R:R:R153	4.28	Yes	Yes	3	5	4
858	R:R:L156	R:R:L160	9.69	No	No	3	7	3
859	R:R:L156	R:R:S176	3	No	No	3	7	3
860	R:R:E157	R:R:F237	4.66	Yes	Yes	3	4	5
861	L:L:?1	R:R:E157	11.56	Yes	Yes	3	0	4
862	R:R:G162	R:R:W158	2.81	No	Yes	0	2	4
863	R:R:F163	R:R:W158	7.02	No	Yes	0	4	4
864	L:L:?1	R:R:W158	6.95	Yes	Yes	3	0	4
865	R:R:L164	R:R:M159	5.65	No	No	0	1	4
866	R:R:L160	R:R:W172	4.56	No	No	0	3	1
867	R:R:L160	R:R:S176	3	No	No	3	3	3
868	R:R:C161	R:R:C173	7.28	No	No	3	4	9
869	L:L:?1	R:R:C161	2.77	Yes	No	3	0	4
870	R:R:F165	R:R:L164	7.31	No	No	0	1	1
871	R:R:F165	R:R:W172	9.02	No	No	0	1	1
872	R:R:A171	R:R:W172	3.89	No	No	0	4	1
873	L:L:?1	R:R:C173	5.54	Yes	No	3	0	9
874	R:R:Q174	R:R:W241	15.33	No	No	0	3	3
875	R:R:D177	R:R:F237	8.36	Yes	Yes	3	4	5
876	R:R:D177	R:R:L240	2.71	Yes	Yes	3	4	4
877	R:R:D177	R:R:W241	7.82	Yes	No	3	4	3
878	L:L:?1	R:R:D177	11.84	Yes	Yes	3	0	4
879	R:R:F237	R:R:T180	7.78	Yes	No	3	5	5
880	R:R:F186	R:R:W183	3.01	No	Yes	0	5	6
881	R:R:L187	R:R:W183	12.53	No	Yes	3	9	6
882	R:R:L184	R:R:L230	2.77	No	Yes	4	8	5
883	R:R:I234	R:R:L184	4.28	No	No	4	6	8
884	R:R:F186	R:R:V190	7.87	No	No	0	5	6
885	R:R:C188	R:R:L230	7.94	No	Yes	0	6	5
886	R:R:L191	R:R:V222	2.98	No	No	0	8	8
887	R:R:F225	R:R:L191	17.05	Yes	No	0	8	8
888	R:R:I218	R:R:S195	3.1	Yes	No	0	8	8
889	R:R:S195	R:R:V222	3.23	No	No	0	8	8
890	R:R:I200	R:R:L196	2.85	No	No	0	5	4
891	R:R:I218	R:R:L198	4.28	Yes	No	0	8	8
892	R:R:I218	R:R:L199	5.71	Yes	No	0	8	5
893	R:R:I202	R:R:L211	2.85	No	Yes	19	6	6
894	R:R:I202	R:R:L214	8.56	No	Yes	19	6	7
895	R:R:L203	R:R:Y215	3.52	No	No	0	5	6
896	R:R:I209	R:R:P210	5.08	No	No	0	4	5
897	R:R:I209	R:R:L211	7.14	No	Yes	0	4	6
898	R:R:L211	R:R:L214	2.77	Yes	Yes	19	6	7
899	R:R:L211	R:R:Y215	8.21	Yes	No	0	6	6
900	R:R:I218	R:R:L214	2.85	Yes	Yes	0	8	7
901	R:R:I271	R:R:L220	2.85	No	No	0	8	6
902	R:R:T221	R:R:Y272	3.75	No	Yes	0	8	9
903	R:R:F225	R:R:L226	3.65	Yes	No	4	8	6
904	R:R:F225	R:R:L230	3.65	Yes	Yes	4	8	5
905	R:R:L226	R:R:L230	5.54	No	Yes	4	6	5
906	R:R:C228	R:R:N264	3.15	No	No	0	8	9
907	R:R:G229	R:R:N264	3.39	No	No	0	8	9
908	R:R:I234	R:R:L230	2.85	No	Yes	4	6	5
909	R:R:F232	R:R:S257	3.96	Yes	No	0	5	6
910	R:R:F232	R:R:I258	2.51	Yes	No	3	5	4
911	R:R:F232	R:R:S261	7.93	Yes	No	3	5	7
912	R:R:I234	R:R:L238	2.85	No	No	0	6	5
913	R:R:F239	R:R:Q235	4.68	No	No	0	4	3
914	R:R:H254	R:R:Q235	9.89	No	No	0	1	3
915	R:R:Q235	R:R:S257	10.11	No	No	0	3	6
916	R:R:F236	R:R:F237	5.36	Yes	Yes	3	4	5
917	R:R:F236	R:R:L240	7.31	Yes	Yes	3	4	4
918	L:L:?1	R:R:F236	3.19	Yes	Yes	3	0	4
919	L:L:?1	R:R:F237	4.25	Yes	Yes	3	0	5
920	R:R:F239	R:R:F250	21.43	No	No	0	4	3
921	R:R:F239	R:R:V253	2.62	No	No	0	4	4
922	R:R:L240	R:R:W241	4.56	Yes	No	3	4	3
923	L:L:?1	R:R:L240	15.69	Yes	Yes	3	0	4
924	R:R:I242	R:R:V244	4.61	No	No	0	1	1
925	R:R:D245	R:R:F250	13.14	No	No	0	3	3
926	R:R:E247	R:R:L249	2.65	No	No	0	2	3
927	R:R:H252	R:R:L249	5.14	No	No	0	1	3
928	R:R:H252	R:R:V253	4.15	No	No	0	1	4
929	R:R:H254	R:R:I258	7.95	No	No	0	1	4
930	R:R:F259	R:R:L263	2.44	No	No	0	5	5
931	R:R:N264	R:R:N268	10.9	No	Yes	0	9	9
932	R:R:F274	R:R:I270	8.79	No	No	0	7	6
933	R:R:F273	R:R:F274	4.29	Yes	No	0	7	7
934	R:R:F273	R:R:S277	2.64	Yes	No	0	7	6
935	B:B:L7	G:G:R13	2.43	No	No	0	8	6
936	B:B:F292	B:B:N313	2.42	No	No	0	4	7
937	R:R:I271	R:R:Y272	2.42	No	Yes	0	8	9
938	B:B:N16	B:B:R19	2.41	No	No	0	1	4
939	A:A:D223	A:A:F208	2.39	No	No	0	9	5
940	B:B:D20	B:B:R19	2.38	No	No	0	2	4
941	R:R:L85	R:R:Y82	2.34	No	No	0	4	3
942	B:B:E130	B:B:R129	2.33	No	No	0	3	3
943	B:B:E130	B:B:R134	2.33	No	No	0	3	3
944	A:A:F212	A:A:R61	2.14	Yes	No	0	9	8
945	B:B:G115	B:B:G116	2.11	No	No	0	9	9
946	B:B:G324	G:G:P49	2.03	No	No	0	9	7
947	R:R:G229	R:R:P231	2.03	No	No	0	8	9
948	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
949	B:B:C317	B:B:G330	1.96	No	No	0	7	5
950	R:R:C192	R:R:G193	1.96	No	No	0	5	4
951	A:A:A226	A:A:G206	1.95	No	No	0	9	8
952	B:B:A140	B:B:G141	1.95	No	No	0	5	5
953	B:B:A208	B:B:G202	1.95	No	No	0	6	6
954	A:A:G304	A:A:S306	1.86	No	No	0	5	7
955	B:B:G244	B:B:S245	1.86	No	No	0	5	9
956	R:R:G78	R:R:S77	1.86	No	No	0	5	5
957	R:R:G167	R:R:S170	1.86	No	No	0	1	3
958	B:B:G244	B:B:V276	1.84	No	No	0	5	6
959	B:B:G306	B:B:V296	1.84	No	No	0	4	5
960	R:R:G41	R:R:V40	1.84	No	No	0	9	6
961	R:R:G44	R:R:V47	1.84	No	No	0	8	6
962	R:R:G276	R:R:V275	1.84	No	No	0	8	8
963	A:A:G52	A:A:T55	1.82	No	No	0	9	9
964	B:B:G115	B:B:T102	1.82	No	No	0	9	8
965	B:B:G182	B:B:T181	1.82	No	No	0	6	2
966	R:R:G44	R:R:T43	1.82	No	No	0	8	5
967	R:R:C188	R:R:C192	1.82	No	No	0	6	5
968	B:B:A104	B:B:C149	1.81	No	Yes	0	7	8
969	B:B:A287	B:B:C250	1.81	No	No	0	6	8
970	A:A:P361	A:A:V346	1.77	No	No	0	5	4
971	R:R:P269	R:R:V48	1.77	No	No	0	9	9
972	G:G:P53	G:G:T52	1.75	No	No	0	8	4
973	R:R:G78	R:R:M102	1.75	No	No	0	5	4
974	A:A:G304	A:A:K305	1.74	No	No	0	5	3
975	B:B:G53	B:B:K89	1.74	No	Yes	0	9	9
976	A:A:A48	A:A:S51	1.71	No	Yes	0	8	9
977	B:B:C103	B:B:V71	1.71	No	Yes	0	8	8
978	B:B:G174	B:B:L139	1.71	No	Yes	0	4	9
979	R:R:G41	R:R:L76	1.71	No	Yes	0	9	7
980	R:R:A171	R:R:S170	1.71	No	No	0	4	3
981	R:R:G193	R:R:L196	1.71	No	No	0	4	4
982	A:A:G52	A:A:N292	1.7	No	Yes	0	9	9
983	A:A:A269	A:A:V248	1.7	No	No	0	9	7
984	A:A:A298	A:A:V334	1.7	No	No	0	4	4
985	A:A:A337	A:A:V301	1.7	No	No	0	8	7
986	B:B:A11	G:G:V16	1.7	No	No	0	5	7
987	B:B:A305	B:B:V40	1.7	No	Yes	0	4	3
988	R:R:A262	R:R:V37	1.7	No	No	0	6	7
989	R:R:A69	R:R:V48	1.7	No	No	0	9	9
990	A:A:D354	A:A:G353	1.68	No	No	0	3	4
991	B:B:K301	B:B:P39	1.67	Yes	No	0	5	1
992	R:R:L260	R:R:P231	1.64	No	No	0	7	9
993	A:A:I26	B:B:A92	1.62	No	No	0	9	6
994	B:B:A92	B:B:I80	1.62	No	No	0	6	8
995	B:B:A140	B:B:I120	1.62	No	No	0	5	6
996	R:R:S194	R:R:V190	1.62	No	No	0	8	6
997	R:R:A267	R:R:I270	1.62	No	No	0	7	6
998	A:A:A372	A:A:M60	1.61	No	No	0	8	9
999	B:B:D38	B:B:P39	1.61	No	No	0	1	1
1000	A:A:S54	A:A:T55	1.6	No	No	0	9	9
1001	B:B:S207	B:B:T223	1.6	No	No	0	5	2
1002	R:R:T31	R:R:V32	1.59	No	No	0	4	6
1003	R:R:T217	R:R:V216	1.59	Yes	No	0	7	7
1004	B:B:A299	B:B:L285	1.58	No	Yes	0	5	6
1005	B:B:A299	B:B:L300	1.58	No	Yes	0	5	6
1006	R:R:A69	R:R:L49	1.58	No	No	0	9	7
1007	A:A:T204	B:B:T143	1.57	No	No	0	9	5
1008	A:A:E327	A:A:P328	1.57	Yes	No	0	4	1
1009	B:B:T165	B:B:T181	1.57	No	No	0	7	2
1010	B:B:T179	B:B:T181	1.57	No	No	0	4	2
1011	A:A:A19	B:B:N88	1.56	No	Yes	0	4	7
1012	B:B:I33	G:G:S31	1.55	No	No	0	3	9
1013	A:A:A324	A:A:D323	1.54	No	No	0	3	4
1014	G:G:A35	G:G:D36	1.54	No	No	0	2	5
1015	R:R:I36	R:R:V32	1.54	No	No	0	5	6
1016	R:R:A168	R:R:D169	1.54	No	No	0	2	3
1017	R:R:I185	R:R:V181	1.54	No	No	0	5	5
1018	A:A:K293	A:A:S366	1.53	Yes	No	0	9	9
1019	A:A:C365	A:A:Q294	1.53	No	Yes	0	8	6
1020	B:B:K280	B:B:S279	1.53	No	Yes	0	1	9
1021	R:R:K208	R:R:S206	1.53	No	No	0	5	6
1022	A:A:M221	A:A:V57	1.52	Yes	No	0	8	7
1023	B:B:Q17	G:G:A23	1.52	No	No	0	4	8
1024	G:G:A12	G:G:Q11	1.52	No	No	0	5	3
1025	R:R:I179	R:R:T175	1.52	No	No	0	5	4
1026	A:A:A316	A:A:E309	1.51	No	No	0	2	4
1027	B:B:G306	B:B:R42	1.5	No	No	0	4	2
1028	B:B:L318	B:B:S275	1.5	Yes	No	0	6	8
1029	R:R:L74	R:R:V101	1.49	No	No	0	7	6
1030	R:R:L238	R:R:V181	1.49	No	No	0	5	5
1031	R:R:L220	R:R:V224	1.49	No	No	0	6	7
1032	R:R:L249	R:R:V248	1.49	No	No	0	3	1
1033	R:R:D169	R:R:S170	1.47	No	No	0	3	3
1034	R:R:D177	R:R:S176	1.47	Yes	No	3	4	3
1035	A:A:D16	A:A:V20	1.46	No	No	0	4	3
1036	G:G:A43	G:G:H44	1.46	No	No	0	4	6
1037	B:B:D322	B:B:T65	1.45	No	No	0	1	1
1038	A:A:K28	A:A:M25	1.44	No	No	0	4	4
1039	A:A:F312	A:A:P313	1.44	No	No	0	8	6
1040	R:R:I94	R:R:L98	1.43	No	No	0	5	4
1041	R:R:I155	R:R:L151	1.43	No	No	0	4	4
1042	B:B:I37	B:B:N36	1.42	Yes	No	0	2	1
1043	B:B:K15	G:G:L19	1.41	No	No	0	6	9
1044	B:B:K301	B:B:N35	1.4	Yes	No	0	5	1
1045	R:R:A46	R:R:F73	1.39	No	No	0	6	7
1046	R:R:H92	R:R:S95	1.39	No	No	0	1	7
1047	R:R:L255	R:R:L30	1.38	No	No	0	2	5
1048	R:R:L226	R:R:L227	1.38	No	No	0	6	5
1049	A:A:K34	A:A:Q31	1.36	No	No	0	4	4
1050	G:G:M21	G:G:Q18	1.36	No	No	0	1	9
1051	R:R:P127	R:R:W126	1.35	No	No	0	9	6
1052	A:A:E299	A:A:L296	1.33	No	Yes	0	6	6
1053	B:B:E10	B:B:L7	1.33	No	No	0	8	8
1054	A:A:R231	A:A:S275	1.32	Yes	No	0	9	8
1055	B:B:E12	B:B:N16	1.31	No	No	0	4	1
1056	R:R:F186	R:R:V189	1.31	No	No	0	5	4
1057	R:R:R246	R:R:V244	1.31	No	No	0	2	1
1058	A:A:D272	A:A:E268	1.3	No	No	0	8	9
1059	R:R:R213	R:R:T217	1.29	No	Yes	0	7	7
1060	R:R:H254	R:R:L255	1.29	No	No	0	1	2
1061	R:R:F178	R:R:I179	1.26	No	No	0	3	5
1062	R:R:F259	R:R:L33	1.22	No	No	0	5	6
1063	B:B:L4	B:B:R8	1.21	No	No	0	4	3
1064	R:R:L211	R:R:R207	1.21	Yes	No	0	6	4
1065	A:A:D229	A:A:R228	1.19	No	Yes	0	8	9
1066	A:A:Q35	A:A:R39	1.17	No	No	0	3	5
1067	B:B:Q44	B:B:R46	1.17	No	No	0	4	5
1068	R:R:R55	R:R:R58	1.07	No	No	0	6	7
1069	R:R:F278	R:R:R213	1.07	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:L41	4.455	4	5	6
2	A:A:L45	4.2	4	0	8
3	A:A:L46	3.42	4	1	8
4	A:A:S51	2.9275	4	16	9
5	A:A:I207	2.8475	4	1	9
6	A:A:F212	5.23	5	5	9
7	A:A:V214	3.35	4	5	6
8	A:A:F219	6.85	6	5	8
9	A:A:M221	3.132	5	5	8
10	A:A:F222	7.276	5	1	7
11	A:A:Q227	5.158	5	1	9
12	A:A:R228	5.405	4	2	9
13	A:A:R231	5.0225	4	0	9
14	A:A:K233	4.59571	7	2	9
15	A:A:C237	2.785	4	1	8
16	A:A:F238	5.71667	6	1	9
17	A:A:I244	4.325	4	1	8
18	A:A:I245	2.7875	4	5	7
19	A:A:F246	2.91	5	1	9
20	A:A:V247	3.8275	4	16	7
21	A:A:Y253	6.674	5	1	8
22	A:A:R265	7.7175	4	17	9
23	A:A:L270	4.225	4	0	6
24	A:A:F273	3.8675	8	1	9
25	A:A:W277	7.22667	6	1	6
26	A:A:W281	7.056	5	1	5
27	A:A:L282	5.2275	4	1	9
28	A:A:I288	3.225	4	5	9
29	A:A:L289	4.46167	6	1	9
30	A:A:F290	4.395	6	5	9
31	A:A:N292	3.3125	4	0	9
32	A:A:K293	5.9525	4	0	9
33	A:A:Q294	5.31	5	1	6
34	A:A:L296	3.545	4	0	6
35	A:A:L297	3.04	4	1	8
36	A:A:F315	10.7675	4	0	6
37	A:A:Y318	5.7925	4	0	6
38	A:A:P321	4.55	4	0	5
39	A:A:E327	6.175	4	1	4
40	A:A:E330	7.4675	4	1	3
41	A:A:Y339	4.0875	4	0	3
42	A:A:F340	9.3075	4	0	7
43	A:A:F345	5.425	6	1	8
44	A:A:S349	4.295	4	1	7
45	A:A:C359	3.7825	4	1	5
46	A:A:Y360	7.076	5	18	8
47	A:A:F363	10.2275	4	1	5
48	A:A:T364	5.276	5	5	9
49	A:A:D368	6.58	4	5	9
50	A:A:N371	6.57	5	5	9
51	A:A:R373	5.31	4	5	5
52	A:A:R374	6.306	5	5	4
53	A:A:F376	4.24833	6	5	8
54	A:A:E390	6.03	4	4	4
55	A:A:Y391	6.765	6	4	4
56	B:B:I37	3.064	5	12	2
57	B:B:V40	4.34	4	12	3
58	B:B:L51	7.484	5	6	9
59	B:B:H54	7.09667	6	6	9
60	B:B:K57	9.22	5	1	9
61	B:B:Y59	5.22	5	1	8
62	B:B:W63	5.7725	4	0	7
63	B:B:V71	3.524	5	11	8
64	B:B:Q75	8.325	4	1	9
65	B:B:D76	7.42	4	0	9
66	B:B:L79	4.44	4	11	7
67	B:B:I81	5.035	4	11	7
68	B:B:W82	8.70286	7	6	9
69	B:B:Y85	10.4425	4	6	4
70	B:B:N88	4.682	5	6	7
71	B:B:K89	5.79667	6	6	9
72	B:B:H91	5.2575	4	0	5
73	B:B:I93	5.13	4	11	7
74	B:B:L95	4.556	5	11	8
75	B:B:W99	6.775	8	1	9
76	B:B:Y105	3.74667	6	11	6
77	B:B:N110	5.4925	4	2	4
78	B:B:Y111	5.406	5	2	4
79	B:B:L117	4.642	5	1	9
80	B:B:I123	3.625	6	2	6
81	B:B:Y124	4.65429	7	11	6
82	B:B:L126	3.8125	4	11	5
83	B:B:V133	5.4075	4	11	4
84	B:B:L139	6.32	4	2	9
85	B:B:H142	5.63857	7	2	9
86	B:B:Y145	5.886	5	2	8
87	B:B:C149	3.87	4	0	8
88	B:B:F151	4.43333	6	2	9
89	B:B:L152	4.748	5	7	3
90	B:B:T159	6.05	4	2	9
91	B:B:S160	4.415	4	0	6
92	B:B:D163	7.0225	4	2	9
93	B:B:C166	3.465	4	7	8
94	B:B:L168	3.68	5	7	6
95	B:B:W169	10.77	5	2	8
96	B:B:D170	4.8625	4	7	9
97	B:B:I171	4.46	4	2	6
98	B:B:Q176	8.0125	4	2	4
99	B:B:F180	6.88667	6	7	7
100	B:B:H183	8.354	5	7	9
101	B:B:D186	5.92	6	2	9
102	B:B:V187	5.425	4	7	9
103	B:B:L190	4.2825	4	0	5
104	B:B:F199	5.81333	6	7	9
105	B:B:V200	5.5025	4	8	6
106	B:B:S201	3.035	4	0	9
107	B:B:C204	3.955	6	2	7
108	B:B:D205	6.315	4	7	9
109	B:B:K209	11.0675	4	7	6
110	B:B:L210	4.592	5	0	5
111	B:B:W211	8.724	5	7	8
112	B:B:D212	7.075	4	14	9
113	B:B:Q220	7.06	4	8	7
114	B:B:F222	6.705	4	8	8
115	B:B:H225	8.435	6	8	9
116	B:B:D228	7.99	4	2	9
117	B:B:I232	4.715	4	8	8
118	B:B:F234	4.01	5	0	5
119	B:B:F235	5.166	5	9	6
120	B:B:P236	5.6675	4	9	7
121	B:B:F241	6.17143	7	8	6
122	B:B:T243	5.065	4	8	8
123	B:B:D247	9.62	4	8	9
124	B:B:T249	6.032	5	8	6
125	B:B:R251	8.18833	6	8	8
126	B:B:F253	6.14667	6	8	6
127	B:B:D254	3.84	4	0	9
128	B:B:D258	5.986	5	8	7
129	B:B:M262	5.7825	4	9	4
130	B:B:T263	3.26	4	8	1
131	B:B:Y264	5.05167	6	9	5
132	B:B:F278	4.52333	6	9	7
133	B:B:S279	2.9875	4	0	9
134	B:B:R283	7.104	5	12	9
135	B:B:L284	3.63	4	0	5
136	B:B:L285	3.89	4	9	6
137	B:B:L286	3.3	4	10	7
138	B:B:Y289	5.86429	7	9	7
139	B:B:D290	7.785	4	1	6
140	B:B:C294	4.32	4	10	5
141	B:B:N295	6.9925	4	9	6
142	B:B:W297	5	4	9	8
143	B:B:L300	4.214	5	12	6
144	B:B:K301	3.8775	4	12	5
145	B:B:R304	5.298	5	9	5
146	B:B:H311	8.106	5	10	9
147	B:B:R314	11	5	1	8
148	B:B:L318	2.972	5	10	6
149	B:B:T321	5.4325	4	13	7
150	B:B:M325	5.9825	4	0	5
151	B:B:T329	5.5625	4	10	8
152	B:B:W332	8.64	7	1	9
153	B:B:D333	6.836	5	10	9
154	B:B:L336	5.085	4	6	7
155	B:B:K337	6.0425	4	10	6
156	B:B:W339	8.08	5	10	9
157	G:G:R27	4.708	5	8	8
158	G:G:L51	4.612	5	12	6
159	G:G:V54	4.3975	4	0	6
160	G:G:P60	5.35	4	0	9
161	G:G:F61	4.7125	8	6	8
162	R:R:L42	3.6975	4	15	7
163	R:R:F61	5.688	5	4	7
164	R:R:Y64	5.27429	7	4	7
165	R:R:L68	6.0575	4	4	9
166	R:R:D72	6.195	4	4	9
167	R:R:F75	5.70667	6	3	6
168	R:R:L76	3.715	4	15	7
169	R:R:R79	7.396	5	3	6
170	R:R:L80	4.645	4	15	7
171	R:R:F87	2.814	5	20	4
172	R:R:Y99	11.938	5	3	3
173	R:R:F104	4.755	4	0	5
174	R:R:Y106	6.37167	6	3	7
175	R:R:F107	6.1475	4	3	6
176	R:R:F112	5.43	6	4	7
177	R:R:L113	6.2675	4	4	8
178	R:R:I128	2.8425	4	5	6
179	R:R:Y130	9.324	5	4	7
180	R:R:R131	5.4575	4	0	6
181	R:R:R134	4.85429	7	4	9
182	R:R:S139	5.3575	4	4	9
183	R:R:W147	5.64	5	4	9
184	R:R:R153	8.314	5	3	4
185	R:R:E157	9.4875	4	3	4
186	R:R:W158	6.225	4	3	4
187	R:R:D177	6.44	5	3	4
188	R:R:W183	5.815	4	3	6
189	R:R:L211	4.436	5	19	6
190	R:R:L214	5.275	4	19	7
191	R:R:T217	2.105	4	0	7
192	R:R:I218	3.985	4	0	8
193	R:R:F225	6.088	5	4	8
194	R:R:L230	4.55	5	4	5
195	R:R:F232	5.386	5	3	5
196	R:R:F236	5.255	4	3	4
197	R:R:F237	5.31143	7	3	5
198	R:R:L240	7.5675	4	3	4
199	R:R:N268	10.5725	4	4	9
200	R:R:Y272	4.384	5	4	9
201	R:R:F273	5.50333	6	21	7
202	L:L:?1	11.07	10	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D76	B:B:L55	16.9379	10.86	Yes	No	0	9	6
2	A:A:Y37	B:B:L55	17.6463	4.69	No	No	0	4	6
3	A:A:R42	A:A:Y37	35.0469	7.2	No	No	0	9	4
4	B:B:A56	B:B:D76	16.9308	4.63	No	Yes	0	7	9
5	A:A:Y37	B:B:A56	17.167	2.67	No	No	0	4	7
6	A:A:F222	A:A:R42	35.2822	4.28	Yes	No	0	7	9
7	A:A:F222	A:A:I207	12.777	2.51	Yes	Yes	1	7	9
8	A:A:F238	A:A:I207	12.3826	2.51	Yes	Yes	1	9	9
9	A:A:F238	A:A:L44	98.668	14.61	Yes	No	1	9	9
10	A:A:L44	A:A:L46	98.5838	5.54	No	Yes	1	9	8
11	A:A:F246	A:A:L46	100	2.44	Yes	Yes	1	9	8
12	A:A:F246	A:A:V248	24.575	2.62	Yes	No	0	9	7
13	A:A:F345	A:A:V248	24.532	6.55	Yes	No	0	8	7
14	A:A:F345	A:A:I341	71.9454	2.51	Yes	No	0	8	8
15	A:A:I341	A:A:S250	71.4819	3.1	No	No	0	8	6
16	A:A:L297	A:A:S250	71.3722	3	Yes	No	1	8	6
17	A:A:L297	A:A:Y253	94.9877	3.52	Yes	Yes	1	8	8
18	A:A:Y253	A:A:Y311	94.5805	7.94	Yes	No	0	8	6
19	A:A:N254	A:A:Y311	94.3335	9.3	No	No	0	9	6
20	A:A:D252	A:A:N254	94.1824	9.42	No	No	0	8	9
21	A:A:D252	A:A:R265	94.0312	3.57	No	Yes	0	8	9
22	A:A:N50	A:A:R265	93.4076	10.85	No	Yes	17	9	9
23	A:A:D249	A:A:N50	93.2741	8.08	No	No	0	8	9
24	A:A:D249	A:A:K293	92.4618	12.44	No	Yes	0	8	9
25	A:A:K293	A:A:N292	91.7197	4.2	Yes	Yes	0	9	9
26	A:A:N292	A:A:T364	88.0521	2.92	Yes	Yes	0	9	9
27	A:A:F290	A:A:T364	81.8209	7.78	Yes	Yes	5	9	9
28	A:A:F290	A:A:I245	76.3645	2.51	Yes	Yes	5	9	7
29	A:A:I245	A:A:L43	76.3859	2.85	Yes	No	5	7	7
30	A:A:F219	A:A:L43	75.8826	7.31	Yes	No	5	8	7
31	A:A:F219	A:A:L41	70.4976	6.09	Yes	Yes	5	8	6
32	A:A:I383	A:A:L41	70.1939	2.85	No	Yes	0	8	6
33	A:A:F222	B:B:W99	23.6853	18.04	Yes	Yes	1	7	9
34	A:A:F238	B:B:W99	16.7167	8.02	Yes	Yes	1	9	9
35	A:A:F246	A:A:F273	25.6963	3.22	Yes	Yes	1	9	9
36	A:A:F273	A:A:F345	24.7845	6.43	Yes	Yes	1	9	8
37	A:A:F246	A:A:L289	49.3965	3.65	Yes	Yes	1	9	9
38	A:A:F345	A:A:L289	24.5307	7.31	Yes	Yes	1	8	9
39	A:A:L289	A:A:L291	24.1208	6.92	Yes	No	1	9	8
40	A:A:F363	A:A:L291	24.1069	7.31	Yes	No	1	5	8
41	A:A:F363	A:A:Q294	23.872	14.05	Yes	Yes	1	5	6
42	A:A:L297	A:A:Q294	23.9336	2.66	Yes	Yes	1	8	6
43	B:B:L117	B:B:M101	13.2898	4.24	Yes	No	0	9	9
44	B:B:M101	B:B:Y145	16.5023	7.18	No	Yes	0	9	8
45	A:A:C237	B:B:Y59	61.6457	2.69	Yes	Yes	1	8	8
46	B:B:W332	B:B:Y59	70.0005	4.82	Yes	Yes	1	9	8
47	A:A:I383	R:R:R131	69.3219	2.51	No	Yes	0	8	6
48	A:A:E390	R:R:R131	67.1192	4.65	Yes	Yes	0	4	6
49	A:A:E390	A:A:Y391	65.4199	7.86	Yes	Yes	4	4	4
50	A:A:Y391	R:R:F61	58.8537	7.22	Yes	Yes	4	4	7
51	B:B:N313	B:B:W332	73.8291	5.65	No	Yes	0	7	9
52	B:B:D333	B:B:N313	73.6639	4.04	Yes	No	0	9	7
53	B:B:D333	B:B:H311	52.3346	6.3	Yes	Yes	10	9	9
54	B:B:H311	B:B:V315	20.6439	4.15	Yes	No	10	9	7
55	B:B:C294	B:B:V315	41.0659	5.12	Yes	No	10	5	7
56	B:B:C294	B:B:G288	61.4521	3.92	Yes	No	0	5	7
57	B:B:G288	B:B:Y289	61.1397	2.9	No	Yes	0	7	7
58	B:B:I273	B:B:Y289	40.1933	9.67	No	Yes	0	6	7
59	B:B:G244	B:B:I273	39.5716	3.53	No	No	0	5	6
60	B:B:G244	B:B:S245	38.6182	1.86	No	No	0	5	9
61	B:B:H225	B:B:S245	37.9785	15.34	Yes	No	8	9	9
62	B:B:H225	B:B:T243	29.6245	6.85	Yes	Yes	8	9	8
63	B:B:F241	B:B:T243	17.3904	2.59	Yes	Yes	8	6	8
64	B:B:D258	B:B:F222	11.6033	4.78	Yes	Yes	8	7	8
65	B:B:D333	B:B:S331	20.7236	5.89	Yes	No	10	9	9
66	B:B:S331	B:B:V315	20.6258	3.23	No	No	10	9	7
67	B:B:H311	B:B:T329	28.2601	5.48	Yes	Yes	10	9	8
68	B:B:C294	B:B:T329	20.5967	5.07	Yes	Yes	10	5	8
69	B:B:W297	B:B:Y289	17.2037	5.79	Yes	Yes	9	8	7
70	B:B:W297	B:B:Y264	16.5906	4.82	Yes	Yes	9	8	5
71	B:B:L51	B:B:W82	11.2922	20.5	Yes	Yes	6	9	9
72	B:B:H54	B:B:W82	19.2708	3.17	Yes	Yes	6	9	9
73	B:B:H54	B:B:S74	23.0289	12.55	Yes	No	0	9	9
74	R:R:F61	R:R:Y272	57.8758	6.19	Yes	Yes	4	7	9
75	R:R:L113	R:R:Y272	57.4672	3.52	Yes	Yes	4	8	9
76	R:R:L113	R:R:L68	17.3135	5.54	Yes	Yes	4	8	9
77	R:R:D72	R:R:L68	14.2842	5.43	Yes	Yes	4	9	9
78	R:R:D72	R:R:S265	20.5157	5.89	Yes	No	0	9	9
79	R:R:L76	R:R:S265	12.2151	4.5	Yes	No	0	7	9
80	R:R:L113	R:R:N268	15.2266	12.36	Yes	Yes	4	8	9
81	R:R:D72	R:R:N268	14.1963	9.42	Yes	Yes	4	9	9
82	R:R:F225	R:R:L113	25.1599	3.65	Yes	Yes	4	8	8
83	R:R:F225	R:R:L110	22.8164	2.44	Yes	No	0	8	7
84	R:R:L110	R:R:Y106	22.6453	5.86	No	Yes	0	7	7
85	R:R:F107	R:R:Y106	14.5022	5.16	Yes	Yes	3	6	7
86	B:B:D76	B:B:S74	23.5016	5.89	Yes	No	0	9	9
87	A:A:F238	B:B:L117	12.4373	2.44	Yes	Yes	1	9	9
88	A:A:C237	A:A:F238	57.2248	2.79	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K96	R:R:W158	8.12	3	No	Yes	5	4	1	1
L:L:?1	R:R:K96	17.22	3	Yes	No	0	5	0	1
R:R:P100	R:R:Y99	5.56	0	No	Yes	4	3	2	1
R:R:M103	R:R:Y99	7.18	3	No	Yes	2	3	2	1
R:R:E157	R:R:Y99	10.1	3	Yes	Yes	4	3	1	1
R:R:F236	R:R:Y99	5.16	3	Yes	Yes	4	3	1	1
L:L:?1	R:R:Y99	31.69	3	Yes	Yes	0	3	0	1
R:R:M103	R:R:R153	2.48	3	No	Yes	2	4	2	2
R:R:F237	R:R:M103	2.49	3	Yes	No	5	2	1	2
R:R:E157	R:R:R153	11.63	3	Yes	Yes	4	4	1	2
R:R:R153	R:R:T180	10.35	3	Yes	No	4	5	2	2
R:R:F237	R:R:R153	4.28	3	Yes	Yes	5	4	1	2
R:R:E157	R:R:F237	4.66	3	Yes	Yes	4	5	1	1
L:L:?1	R:R:E157	11.56	3	Yes	Yes	0	4	0	1
R:R:G162	R:R:W158	2.81	0	No	Yes	2	4	2	1
R:R:F163	R:R:W158	7.02	0	No	Yes	4	4	2	1
L:L:?1	R:R:W158	6.95	3	Yes	Yes	0	4	0	1
R:R:C161	R:R:C173	7.28	3	No	No	4	9	1	1
L:L:?1	R:R:C161	2.77	3	Yes	No	0	4	0	1
L:L:?1	R:R:C173	5.54	3	Yes	No	0	9	0	1
R:R:D177	R:R:F237	8.36	3	Yes	Yes	4	5	1	1
R:R:D177	R:R:L240	2.71	3	Yes	Yes	4	4	1	1
R:R:D177	R:R:W241	7.82	3	Yes	No	4	3	1	2
L:L:?1	R:R:D177	11.84	3	Yes	Yes	0	4	0	1
R:R:F237	R:R:T180	7.78	3	Yes	No	5	5	1	2
R:R:F236	R:R:F237	5.36	3	Yes	Yes	4	5	1	1
R:R:F236	R:R:L240	7.31	3	Yes	Yes	4	4	1	1
L:L:?1	R:R:F236	3.19	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:F237	4.25	3	Yes	Yes	0	5	0	1
R:R:L240	R:R:W241	4.56	3	Yes	No	4	3	1	2
L:L:?1	R:R:L240	15.69	3	Yes	Yes	0	4	0	1
R:R:D177	R:R:S176	1.47	3	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
58.33	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
41.67	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
40.00	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
35.29	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
33.33	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
33.33	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
30.00	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57	Single	7S8N	(R)-Zinc-3573	7S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
25.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
23.53	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.08	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
22.73	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
22.73	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
22.73	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
22.22	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
21.74	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
21.74	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
21.43	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
21.05	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
21.05	Single	6E59	L-760735	6E59-NK₁-L-760735
21.05	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
21.05	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
21.05	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
21.05	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
21.05	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
20.83	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
20.83	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
20.00	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
20.00	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
20.00	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
20.00	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
20.00	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
20.00	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
20.00	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.23	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.23	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.05	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
19.05	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
18.75	Single	5WS3	EMPA	5WS3-OX₂-EMPA
18.75	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
18.75	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
18.75	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
18.75	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
18.75	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
18.75	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
18.75	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
18.75	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
18.52	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
18.18	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
17.86	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
17.65	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
17.65	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
17.65	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
17.65	Single	6TPK	Retosiban	6TPK-OT-Retosiban
17.65	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
17.65	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
17.65	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
17.65	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
17.65	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
17.65	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
17.39	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
16.67	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
16.67	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
16.67	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
16.67	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
16.67	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
16.67	Consensus	cck_off	Orthosteric Ligand	ccka_off
16.67	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
16.67	Consensus	ffa_on	Orthosteric Ligand	ffa4_on ffa1_on ffa2_on ffa3_on
16.67	Consensus	p2y12_off	Orthosteric Ligand	4NTJ-P2Y₁₂-AZD1283 7PP1-P2Y₁₂-Selatogrel
16.67	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
16.13	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
16.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
16.00	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.00	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
15.79	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
15.79	Single	5WQC	EMPA	5WQC-OX₂-EMPA
15.79	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
15.79	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
15.79	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
15.79	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
15.79	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
15.79	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
15.79	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
15.38	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.38	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.38	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.00	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
15.00	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
15.00	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
15.00	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
15.00	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
15.00	Single	7W41	PD176252	7W41-BB₂-PD176252
15.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
15.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
15.00	Consensus	cyslt1_off_ortoallo	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
15.00	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Consensus	nk1_off	Orthosteric Ligand	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
15.00	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
14.81	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
14.81	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
14.29	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
14.29	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
14.29	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
14.29	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
14.29	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
14.29	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
14.29	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
14.29	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
14.29	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
14.29	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
14.29	Consensus	nts_off	Orthosteric Ligand	nts1_off
14.29	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
13.79	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
13.64	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8ID8	TUG-891	8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
13.64	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
13.64	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
13.64	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
13.33	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
13.33	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
13.33	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.33	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
13.04	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.04	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.04	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
13.04	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8SAI	1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine	8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.04	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
13.04	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
13.04	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	6HLL	CP99994	6HLL-NK₁-CP99994
12.50	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.50	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
12.50	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.50	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
12.50	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
12.00	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
12.00	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.00	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
12.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Consensus	sst_off	Orthosteric Ligand	sst2_off
12.00	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
11.76	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
11.76	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.76	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
11.76	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.76	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
11.76	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.76	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.76	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.76	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.76	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.76	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
11.76	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.76	Consensus	ffa3_on_allo	Orthosteric Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.76	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
11.76	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.76	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
11.54	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
11.54	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
11.54	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
11.54	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
11.54	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
11.54	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
11.54	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
11.54	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
11.54	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
11.54	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
11.11	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
11.11	Single	6IQL	L745870	6IQL-D₄-L745870
11.11	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11	Single	6TPG	EMPA	6TPG-OX₂-EMPA
11.11	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
11.11	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
11.11	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
11.11	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
11.11	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.11	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
11.11	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
11.11	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.11	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
11.11	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
11.11	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.11	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
11.11	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
11.11	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
10.71	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.71	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.71	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
10.71	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.71	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.71	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
10.71	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
10.71	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.71	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
10.53	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
10.53	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
10.53	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
10.53	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
10.53	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
10.53	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.53	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
10.53	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.53	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
10.53	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
10.53	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
10.53	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.53	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
10.53	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
10.34	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
10.34	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
10.34	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.34	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
10.34	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.34	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
10.34	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.34	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.34	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
10.00	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
10.00	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
10.00	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
10.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
10.00	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
10.00	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
10.00	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
10.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
10.00	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
10.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
10.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
10.00	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.00	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
10.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.00	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
10.00	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
10.00	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
10.00	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.00	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
10.00	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.00	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
10.00	Single	8QOT	Nanobody E	8QOT-μ-Nanobody E
10.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
10.00	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
10.00	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
10.00	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.68	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
9.68	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
9.52	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
9.52	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
9.52	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
9.52	Single	4DJH	JDTic	4DJH-κ-JDTic
9.52	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
9.52	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
9.52	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
9.52	Single	5X93	K-8794	5X93-ET_B-K-8794
9.52	Single	5XRA	AM11542	5XRA-CB₁-AM11542
9.52	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
9.52	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
9.52	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
9.52	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
9.52	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
9.52	Single	7EPE	NAM563	7EPE-mGlu-NAM563
9.52	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
9.52	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
9.52	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
9.52	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
9.52	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
9.52	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
9.52	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
9.52	Single	7P2L	4YI	7P2L-mGlu₅-4YI
9.52	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
9.52	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
9.52	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
9.52	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
9.52	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
9.52	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
9.52	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
9.52	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.52	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
9.52	Single	8E0G	BU72	8E0G-μ-BU72
9.52	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
9.52	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
9.52	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.52	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
9.52	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
9.52	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
9.52	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
9.52	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.52	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
9.52	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
9.52	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
9.52	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
9.52	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
9.52	Consensus	gs_ffa	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2 8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
9.52	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
9.52	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.52	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
9.52	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
9.52	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.52	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
9.52	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.38	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.38	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
9.09	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
9.09	Single	4LDE	BI167107	4LDE-β₂-BI167107
9.09	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
9.09	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
9.09	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
9.09	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
9.09	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
9.09	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
9.09	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.09	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
9.09	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
9.09	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
9.09	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.09	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
9.09	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
9.09	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
9.09	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
9.09	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.09	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
9.09	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
9.09	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
9.09	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
9.09	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
9.09	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.09	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.09	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
9.09	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
9.09	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
9.09	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
9.09	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
9.09	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
8.70	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
8.70	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
8.70	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
8.70	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
8.70	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
8.70	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
8.70	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
8.70	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
8.70	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
8.70	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
8.70	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
8.70	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
8.70	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
8.70	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
8.70	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.70	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
8.70	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.70	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
8.70	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
8.70	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
8.70	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
8.70	Consensus	endothelin_off	Orthosteric Ligand	etb_off
8.70	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
8.70	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.70	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
8.70	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70	Consensus	orexin_on	Orthosteric Ligand	ox2_on
8.70	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.70	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
8.33	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
8.33	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
8.33	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
8.33	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
8.33	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.33	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
8.33	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
8.33	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
8.33	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
8.33	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
8.33	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
8.33	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
8.33	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.33	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
8.33	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.33	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
8.33	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
8.33	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
8.33	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
8.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
8.00	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.00	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
8.00	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
8.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
8.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
8.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
8.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
8.00	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
8.00	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.00	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
8.00	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
8.00	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
8.00	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
8.00	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
8.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
7.69	Single	5MZP	Caffeine	5MZP-A_2A-Caffeine-Na
7.69	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
7.69	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
7.69	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.69	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.69	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.69	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
7.69	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
7.69	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
7.69	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
7.69	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
7.69	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
7.69	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
7.69	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.41	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
7.41	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
7.41	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.41	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.41	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
7.41	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
7.41	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
7.41	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
7.14	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
7.14	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
7.14	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
7.14	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.14	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
7.14	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
7.14	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
7.14	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
7.14	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
6.90	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
6.90	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
6.67	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.67	Single	6OY9	All-trans-retinal	6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
6.67	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
6.67	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.67	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
6.67	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
6.67	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
6.45	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.45	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.45	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
6.45	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
6.25	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
6.25	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
6.25	Single	3UZA	GTPL9236	3UZA-A_2A-GTPL9236
6.25	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.25	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
6.25	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
6.25	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
6.25	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
6.25	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.25	Single	8EIT	Doconexent	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
6.25	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
6.25	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
6.25	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
6.25	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
6.25	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.25	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.25	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
6.25	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
6.06	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
6.06	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
6.06	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
5.88	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
5.88	Single	3PBL	Eticlopride	3PBL-D₃-Eticlopride
5.88	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.88	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
5.88	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
5.88	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
5.88	Single	6QNO	All-trans-retinal	6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7E2Y	Serotonin	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
5.88	Single	7SRQ	LSD	7SRQ-5-HT_2B-LSD
5.88	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
5.88	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2
5.88	Single	7XTB	Serotonin	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2
5.88	Single	7YS6	Serotonin	7YS6-5-HT₆-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
5.88	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/&β;1/&γ;2
5.88	Single	8GH1	Epinephrine	8GH1-β₂-Epinephrine
5.88	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.88	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
5.88	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
5.88	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.88	Consensus	5ht4_on	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.88	Consensus	class-t_on	Orthosteric Ligand	taste2_on
5.88	Consensus	d3_off	Orthosteric Ligand	3PBL-D₃-Eticlopride
5.88	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
5.88	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.88	Consensus	go_protein	Orthosteric Ligand	go_chemokine
5.88	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
5.88	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.88	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.71	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
5.71	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
5.56	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
5.56	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
5.56	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
5.56	Single	3VG9	ZM241385	3VG9-A_2A-ZM241385-Antibody
5.56	Single	3VGA	ZM241385	3VGA-A_2A-ZM241385-Antibody
5.56	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.56	Single	5K2D	ZM241385	5K2D-A_2A-ZM241385
5.56	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
5.56	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
5.56	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
5.56	Single	6AKX	A4R	6AKX-CCR5-A4R
5.56	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.56	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.56	Single	6JZH	ZM241385	6JZH-A_2A-ZM241385-Na
5.56	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.56	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56	Single	6PS7	ZM241385	6PS7-A_2A-ZM241385-Na
5.56	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
5.56	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.56	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.56	Single	7DHR	Isoprenaline	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
5.56	Single	7EJ0	L-Norepinephrine	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2
5.56	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
5.56	Single	7F24	Dopamine	7F24-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.56	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
5.56	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Single	7LJD	Dopamine	7LJD-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;1
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.56	Single	7SRR	LSD	7SRR-5-HT_2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SRS	LSD	7SRS-5-HT_2B-LSD-Arrestin2
5.56	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
5.56	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.56	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
5.56	Single	7X2F	Dopamine	7X2F-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.56	Single	7X5H	5-CT	7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2
5.56	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2
5.56	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.56	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.56	Single	8G94	CD69	8G94-S1P₁-CD69-Gi1/&β;1/&γ;2
5.56	Single	8GED	Epinephrine	8GED-β₂-Epinephrine-Gs/&β;1/&γ;2
5.56	Single	8GG9	Epinephrine	8GG9-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GGF	Epinephrine	8GGF-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
5.56	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2
5.56	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
5.56	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
5.56	Single	8IW4	Spermidine	8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	8IWE	Spermidine	8IWE-TAAR9-Spermidine
5.56	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2
5.56	Single	8UNL	Epinephrine	8UNL-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNT	Epinephrine	8UNT-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNU	Epinephrine	8UNU-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UNW	Epinephrine	8UNW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8UO0	Epinephrine	8UO0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Consensus	5ht_on	Orthosteric Ligand	5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
5.56	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Consensus	a2a_off_allo	Orthosteric Ligand	6ZDR-A_2A-HMS1413f12-Na 6GT3-A_2A-Imaradenant-Na 8CU7-A_2A-LJ-4517-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PubChem 92460631; psb36-Na 5MZJ-A_2A-Theophylline-Na 5OLO-A_2A-Tozadenant-Na 5OLH-A_2A-Vipadenant-Na 5NM4-A_2A-ZM241385-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5MZP-A_2A-Caffeine-Na 8CIC-A_2A-Etrumadenant-Na
5.56	Consensus	alpha2_off	Orthosteric Ligand	alpha2a_off alpha2c_off
5.56	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.56	Consensus	gi_nucleotide	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/&β;1/&γ;2
5.56	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.56	Consensus	gs_5ht	Orthosteric Ligand	7XT8-5-HT₄-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT_2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT_2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	mglu_on	Other Ligand	mglu2_on mglu4_on
5.56	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
5.26	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.26	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
5.26	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
5.26	Single	3UZC	PubChem 135566609	3UZC-A_2A-PubChem 135566609
5.26	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
5.26	Single	4DKL	Beta-funaltrexamine	4DKL-μ-Beta-funaltrexamine
5.26	Single	4LDO	L-Epinephrine	4LDO-β₂-L-Epinephrine
5.26	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.26	Single	5IU4	ZM241385	5IU4-A_2A-ZM241385-Na
5.26	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.26	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
5.26	Single	5JTB	ZM241385	5JTB-A_2A-ZM241385
5.26	Single	5K2B	ZM241385	5K2B-A_2A-ZM241385-Na
5.26	Single	5K2C	ZM241385	5K2C-A_2A-ZM241385-Na
5.26	Single	5NLX	ZM241385	5NLX-A_2A-ZM241385-Na
5.26	Single	5NM4	ZM241385	5NM4-A_2A-ZM241385-Na
5.26	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.26	Single	5UVI	ZM241385	5UVI-A_2A-ZM241385
5.26	Single	6AQF	ZM241385	6AQF-A_2A-ZM241385
5.26	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.26	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.26	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.26	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.26	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.26	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
5.26	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.26	Single	6PS4	ICI 118-551	6PS4-β₂-ICI 118-551
5.26	Single	6PS5	(S)-Propranolol	6PS5-β₂-(S)-Propranolol
5.26	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
5.26	Single	6VI4	JDTic	6VI4-κ-JDTic
5.26	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
5.26	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.26	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
5.26	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
5.26	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
5.26	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.26	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.26	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Single	7CMU	Pramipexole	7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/&β;1/&γ;2
5.26	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2
5.26	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2
5.26	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/&β;1/&γ;2
5.26	Single	7RAN	PubChem 164575847	7RAN-5-HT_2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.26	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.26	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
5.26	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.26	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.26	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8GEG	Epinephrine	8GEG-β₂-Epinephrine-Gs/&β;1/&γ;2
5.26	Single	8GG3	Epinephrine	8GG3-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GG5	Epinephrine	8GG5-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8GGK	Epinephrine	8GGK-β₂-Epinephrine
5.26	Single	8GGL	Epinephrine	8GGL-β₂-Epinephrine
5.26	Single	8GGM	Epinephrine	8GGM-β₂-Epinephrine
5.26	Single	8GGP	Epinephrine	8GGP-β₂-Epinephrine
5.26	Single	8GGQ	Epinephrine	8GGQ-β₂-Epinephrine
5.26	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
5.26	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
5.26	Single	8HQN	9(S)-HODE	8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
5.26	Single	8IYX	YL-365	8IYX-GPR34-YL-365
5.26	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.26	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
5.26	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
5.26	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
5.26	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
5.26	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
5.26	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26	Single	8UNR	Epinephrine	8UNR-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNS	Epinephrine	8UNS-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UNZ	Epinephrine	8UNZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Single	8UO2	Epinephrine	8UO2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.26	Consensus	5ht1e_on	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2
5.26	Consensus	5ht5_on	Orthosteric Ligand	5ht5a_on
5.26	Consensus	5ht5a_on	Orthosteric Ligand	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Consensus	alpha2b_on	Orthosteric Ligand	6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2
5.26	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
5.26	Consensus	d1_on_allo	Orthosteric Ligand	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D₁-Dopamine-Mevidalen-Gs/&β;1/&γ;2
5.26	Consensus	d3_on	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
5.26	Consensus	dop_off_allo	Orthosteric Ligand	4N6H-δ-Naltrindole-Na
5.26	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
5.26	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
5.26	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
5.26	Consensus	hcar_on	Orthosteric Ligand	hca_on
5.26	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
5.26	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
5.26	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
5.13	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.00	Single	2VT4	Cyanopindolol	2VT4-β₁-Cyanopindolol
5.00	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.00	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
5.00	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
5.00	Single	3EML	ZM241385	3EML-A_2A-ZM241385
5.00	Single	3NY8	ICI 118-551	3NY8-β₂-ICI 118-551
5.00	Single	3NYA	(S)-Alprenolol	3NYA-β₂-(S)-Alprenolol
5.00	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
5.00	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
5.00	Single	4EIY	ZM241385	4EIY-A_2A-ZM241385-Na
5.00	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.00	Single	4GBR	(S)-Carazolol	4GBR-β₂-(S)-Carazolol
5.00	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
5.00	Single	4X1H	Nonyl Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
5.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
5.00	Single	5JQH	(S)-Carazolol	5JQH-β₂-(S)-Carazolol
5.00	Single	5K2A	ZM241385	5K2A-A_2A-ZM241385-Na
5.00	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
5.00	Single	5OLG	ZM241385	5OLG-A_2A-ZM241385-Na
5.00	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
5.00	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
5.00	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
5.00	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
5.00	Single	5UEN	DU172	5UEN-A₁-DU172
5.00	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
5.00	Single	5VRA	ZM241385	5VRA-A_2A-ZM241385-Na
5.00	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.00	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
5.00	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
5.00	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
5.00	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.00	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
5.00	Single	6LPJ	ZM241385	6LPJ-A_2A-ZM241385-Na
5.00	Single	6LPK	ZM241385	6LPK-A_2A-ZM241385-Na
5.00	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
5.00	Single	6PRZ	(S)-Alprenolol	6PRZ-β₂-(S)-Alprenolol
5.00	Single	6PS0	(S)-Carazolol	6PS0-β₂-(S)-Carazolol
5.00	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.00	Single	6PS2	(S)-Alprenolol	6PS2-β₂-(S)-Alprenolol
5.00	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.00	Single	6S0L	ZM241385	6S0L-A_2A-ZM241385
5.00	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.00	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
5.00	Single	7BTS	L-Epinephrine	7BTS-β₁-L-Epinephrine
5.00	Single	7BU6	L-Norepinephrine	7BU6-β₁-L-Norepinephrine
5.00	Single	7BU7	BI167107	7BU7-β₁-BI167107
5.00	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/&β;1/&γ;2
5.00	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/&β;1/&γ;2
5.00	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.00	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
5.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
5.00	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
5.00	Single	7LJC	PubChem 86764103	7LJC-D₁-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
5.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
5.00	Single	7S0G	Isoprenaline	7S0G-β₁-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
5.00	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
5.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
5.00	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
5.00	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
5.00	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
5.00	Single	7UM5	5-CT	7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	7UM6	Lisuride	7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
5.00	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
5.00	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
5.00	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.00	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
5.00	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.00	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
5.00	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.00	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
5.00	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
5.00	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.00	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
5.00	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
5.00	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
5.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
5.00	Single	8GE3	Epinephrine	8GE3-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEE	Epinephrine	8GEE-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GEH	Epinephrine	8GEH-β₂-Epinephrine-Gs/&β;1/&γ;2
5.00	Single	8GFW	Epinephrine	8GFW-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFX	Epinephrine	8GFX-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFY	Epinephrine	8GFY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GFZ	Epinephrine	8GFZ-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG0	Epinephrine	8GG0-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG1	Epinephrine	8GG1-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG2	Epinephrine	8GG2-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GG6	Epinephrine	8GG6-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGB	Epinephrine	8GGB-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8GGJ	Epinephrine	8GGJ-β₂-Epinephrine
5.00	Single	8GGN	Epinephrine	8GGN-β₂-Epinephrine
5.00	Single	8GGO	Epinephrine	8GGO-β₂-Epinephrine
5.00	Single	8GGU	Epinephrine	8GGU-β₂-Epinephrine
5.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
5.00	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.00	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
5.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.00	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
5.00	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
5.00	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
5.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
5.00	Single	8UNM	Epinephrine	8UNM-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UNN	Epinephrine	8UNN-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8UNP	Epinephrine	8UNP-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
5.00	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
5.00	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
5.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
5.00	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2
5.00	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT₆-ST1936-Gs/&β;1/&γ;2
5.00	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/&β;1/&γ;2
5.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.00	Consensus	a2a_off	Orthosteric Ligand	8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 5UIG-A_2A-J3.651.884G 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-PubChem 168451710 5K2D-A_2A-ZM241385
5.00	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on
5.00	Consensus	adrenergic_on	Orthosteric Ligand	beta_on alpha_on
5.00	Consensus	alpha2_on	Orthosteric Ligand	alpha2a_on alpha2b_on
5.00	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
5.00	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.00	Consensus	blt_on	Orthosteric Ligand	blt1_on
5.00	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.00	Consensus	dopamine_on	Orthosteric Ligand	d3_on d2_on d5_on d1_on
5.00	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
5.00	Consensus	gi_5ht	Orthosteric Ligand	7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT_1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT_1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT₄-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT_5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2
5.00	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
5.00	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
5.00	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
5.00	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
5.00	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
5.00	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
5.00	Consensus	hcar_off	Orthosteric Ligand	succinate_off
5.00	Consensus	leuko_on	Orthosteric Ligand	blt_on
5.00	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
5.00	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on
5.00	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
5.00	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.76	Single	2RH1	(S)-Carazolol	2RH1-β₂-(S)-Carazolol
4.76	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.76	Single	2YCW	(S)-Carazolol	2YCW-β₁-(S)-Carazolol
4.76	Single	5C1M	BU72	5C1M-μ-BU72
4.76	Single	5D6L	(S)-Carazolol	5D6L-β₂-(S)-Carazolol
4.76	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
4.76	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
4.76	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.76	Single	5NM2	ZM241385	5NM2-A_2A-ZM241385-Na
4.76	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.76	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
4.76	Single	5TVN	LSD	5TVN-5-HT_2B-LSD
4.76	Single	5X7D	(S)-Carazolol	5X7D-β₂-(S)-Carazolol-PubChem 129318963
4.76	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
4.76	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.76	Single	6GPX	MK0812	6GPX-CCR2-MK0812
4.76	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
4.76	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76	Single	6LPL	ZM241385	6LPL-A_2A-ZM241385-Na
4.76	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.76	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
4.76	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
4.76	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.76	Single	6S0Q	ZM241385	6S0Q-A_2A-ZM241385
4.76	Single	6WQA	ZM241385	6WQA-A_2A-ZM241385-Na
4.76	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.76	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
4.76	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.76	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
4.76	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
4.76	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
4.76	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Single	7RM5	ZM241385	7RM5-A_2A-ZM241385-Na
4.76	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
4.76	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.76	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
4.76	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.76	Single	7WC6	LSD	7WC6-5-HT_2A-LSD
4.76	Single	7XKA	Epinephrine	7XKA-β₂-Epinephrine
4.76	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
4.76	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.76	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.76	Single	8FYN	ZM241385	8FYN-A_2A-ZM241385-Na
4.76	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.76	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
4.76	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.76	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
4.76	Single	8UNY	Epinephrine	8UNY-β₂-Epinephrine-GTP-Gs/&β;1/&γ;2
4.76	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
4.76	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
4.76	Consensus	a1_on_allo	Orthosteric Ligand	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
4.76	Consensus	a2a_on	Orthosteric Ligand	6GDG-A_2A-NECA-Gs/&β;1/&γ;1
4.76	Consensus	adrenergic_off	Orthosteric Ligand	beta_off alpha_off
4.76	Consensus	alpha2a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.76	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
4.76	Consensus	amine_off	Orthosteric Ligand	adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.76	Consensus	beta2_off	Orthosteric Ligand	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
4.76	Consensus	beta2_on	Orthosteric Ligand	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2
4.76	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.76	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
4.76	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.76	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.76	Consensus	go_amine	Orthosteric Ligand	go_adrenergic go_muscarinic go_5ht
4.76	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
4.55	Single	2YDV	NECA	2YDV-A_2A-NECA
4.55	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.55	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
4.55	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.55	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.55	Single	5D5A	(S)-Carazolol	5D5A-β₂-(S)-Carazolol
4.55	Single	5D5B	(S)-Carazolol	5D5B-β₂-(S)-Carazolol
4.55	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.55	Single	5V56	TC114	5V56-SMO-TC114
4.55	Single	5XR8	AM841	5XR8-CB₁-AM841
4.55	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.55	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
4.55	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
4.55	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
4.55	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.55	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.55	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
4.55	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
4.55	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.55	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
4.55	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.55	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
4.55	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
4.55	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
4.55	Single	7W6P	W96	7W6P-α_2a-W96-Go/&β;1/&γ;2
4.55	Single	7W7E	W58	7W7E-α_2a-W58-Go/&β;1/&γ;2
4.55	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/&β;1/&γ;2
4.55	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
4.55	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
4.55	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
4.55	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
4.55	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.55	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
4.55	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
4.55	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2
4.55	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
4.55	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
4.55	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
4.55	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
4.55	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
4.55	Consensus	5ht1b_on	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.55	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
4.55	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht5_off 5ht1_off
4.55	Consensus	a2_on	Orthosteric Ligand	a2a_on a2b_on
4.55	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.55	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
4.55	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCZ-β₁-Iodocyanopindolol
4.55	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
4.55	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
4.55	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.55	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
4.55	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.55	Consensus	go_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α_2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α_2a-W58-Go/&β;1/&γ;2 7W6P-α_2a-W96-Go/&β;1/&γ;2 6K41-α_2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α_2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α_2a-Dexmedetomidine-Go/&β;1/&γ;2
4.55	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.55	Consensus	h1_off	Orthosteric Ligand	3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole 8X63-H₁-Mepyramine 8X64-H₁-Desloratadine
4.55	Consensus	histamine_off	Orthosteric Ligand	h1_off
4.55	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
4.55	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
4.35	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.35	Single	3D4S	Timolol Maleate	3D4S-β₂-Timolol Maleate
4.35	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.35	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
4.35	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.35	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
4.35	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
4.35	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.35	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
4.35	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.35	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.35	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
4.35	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.35	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
4.35	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
4.35	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.35	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.35	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.35	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
4.35	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
4.35	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.35	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.35	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
4.35	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
4.35	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.35	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
4.35	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
4.35	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
4.35	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
4.35	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
4.35	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.35	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
4.35	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
4.35	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
4.35	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
4.35	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
4.35	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
4.35	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
4.35	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
4.35	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
4.35	Consensus	gi_class-f	Other Ligand	gi_frizzled
4.35	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35	Consensus	go_5ht	Orthosteric Ligand	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT_5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
4.35	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.35	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.35	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.35	Consensus	nts_on	Orthosteric Ligand	nts1_on
4.35	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
4.17	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.17	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.17	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.17	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.17	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.17	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/&β;1/&γ;2
4.17	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.17	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.17	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
4.17	Single	7EZC	UKA	7EZC-A_2A-UKA
4.17	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.17	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
4.17	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
4.17	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.17	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.17	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
4.17	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
4.17	Single	8E9Y	PubChem 446603	8E9Y-M₃-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.17	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
4.17	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
4.17	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
4.17	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
4.17	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	beta1_off_allo	Orthosteric Ligand	4BVN-β₁-Cyanopindolol-Na
4.17	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
4.17	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
4.17	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
4.17	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Single	3NY9	PubChem 913103	3NY9-β₂-PubChem 913103
4.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
4.00	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
4.00	Single	6PT3	DPI-287	6PT3-δ-DPI-287
4.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.00	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
4.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.00	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
4.00	Consensus	class-d_off	Orthosteric Ligand	ste2_off
4.00	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.00	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
4.00	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
3.85	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
3.85	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.85	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
3.85	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.85	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.85	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.85	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
3.85	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.85	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
3.85	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
3.85	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
3.85	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
3.85	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
3.85	Consensus	class-d_off	Orthosteric Ligand	ste2_off
3.85	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
3.85	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
3.85	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
3.70	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.70	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.70	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
3.70	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.70	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
3.70	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
3.70	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
3.70	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.70	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
3.70	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
3.57	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.57	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.57	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
3.57	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
3.57	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
3.45	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
3.45	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
3.45	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.45	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.45	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.45	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.45	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.45	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.45	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.33	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.33	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
3.33	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.33	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.33	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.33	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
3.23	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
3.23	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.23	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
3.23	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.23	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
3.23	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.12	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.12	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
3.12	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
3.12	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.12	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.12	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
3.12	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.12	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.12	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.12	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.03	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.03	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.03	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.03	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.03	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
3.03	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
2.86	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.86	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.78	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.78	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.70	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.70	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.63	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.63	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.63	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.56	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.50	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.44	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.27	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	8HJ5
Class	A
SubFamily	Orphan
Type	A orphans
SubType	MRGPRX1
Species	Homo sapiens
Ligand	PubChem 139030531
Other Ligand(s)	-
Protein Partners	chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution	3
Date	2023-05-31
D.O.I.	10.1371/journal.pbio.3001975

Net Summary
I_min	2.44
Number of Linked Nodes	813
Number of Links	1069
Number of Hubs	202
Number of Links mediated by Hubs	725
Number of Communities	22
Number of Nodes involved in Communities	306
Number of Links involved in Communities	470

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	3894010
Length Of Smallest Path	3
Average Path Length	40.6116
Length of Longest Path	67
Minimum Path Strength	1.18
Average Path Strength	5.88583
Maximum Path Strength	24.455
Minimum Path Correlation	0.7
Average Path Correlation	0.990799
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.43902
Average % Of Corr. Nodes	31.9962
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.216
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U2U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U2U
Name	N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide
Synonyms
Identifier	~{N}-[2-(1-azanylisoquinolin-6-yl)oxy-4-methyl-phenyl]-2-methoxy-benzenesulfonamide
Formula	C23 H21 N3 O4 S
Molecular Weight	435.496
SMILES	Cc1ccc(c(c1)Oc2ccc3c(c2)ccnc3N)NS(=O)(=O)c4ccccc4OC
PubChem	139030531
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8HJ5_Chain_A C T L S A E D K A A V E R S K M I E K Q L Q K D K Q V Y R R T L R L L L L G A D N S G K S T I V K Q M R T S G I F E T K F Q V D K V N F H M F D V G A Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R K E F V D I S T A S G D G R H I C Y P H F T C S V D T E N A R R I F N D C K D I I L Q M N L R E Y N L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8HJ5_Chain_B L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8HJ5_Chain_G Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q96LB2
Sequence	>8HJ5_Chain_R Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M R R N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I S P H T I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P I W Y R C H R P T H L S A V V C V L L W A L S L L R S I L E W M L C G F L F S G A D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C G S R K I P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H V D R E V L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8DWC	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Proenkephalin-A	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.87	2022-11-02	10.1038/s41589-022-01173-6
	8DWG	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Proenkephalin-A	ML382	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.71	2022-11-02	10.1038/s41589-022-01173-6
	8DWH	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Compound-16	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.25	2022-11-02	10.1038/s41589-022-01173-6
	8HJ5	A	Orphan	A orphans	MRGPRX1	Homo sapiens	PubChem 139030531	-	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	3	2023-05-31	10.1371/journal.pbio.3001975
	8JGB	A	Orphan	A orphans	MRGPRX1	Homo sapiens	Conorfamide-Tx2	-	Gi1/&β;1/&γ;2	2.84	2024-01-10	10.1038/s41467-023-40705-z
	8JGF	A	Orphan	A orphans	MRGPRX1	Homo sapiens	BAM8-22	-	chim(NtGi1-Gs-CtGq)/&β;1/&γ;2	2.7	2024-01-10	10.1038/s41467-023-40705-z
	8JGG	A	Orphan	A orphans	MRGPRX1	Homo sapiens	BAM8-22	-	Gi1/&β;1/&γ;2	3	2024-01-10	10.1038/s41467-023-40705-z

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