psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

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Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	ConSurf1	ConSurf2
1	1x29	1x31	3.5425	No	No	3	3
2	1x31	1x35	4.655	No	No	3	5
3	1x35	1x39	4.6925	No	Yes	5	6
4	1x39	7x39	10.47	Yes	Yes	6	5
5	1x42	7x39	3.2275	No	Yes	6	5
6	1x42	7x43	3.8425	No	No	6	5
7	1x43	2x58	6.63	No	No	6	8
8	1x46	2x54	4.85	No	No	8	7
9	1x46	7x46	3.87	No	No	8	9
10	1x50	2x50	12.455	Yes	Yes	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

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Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	1x39	4.67375	4	0	6
2	1x48	2.14625	4	0	4
3	1x50	6.7875	4	0	9
4	1x60	5.354	5	0	6
5	I1x49	3.5275	4	0	6
6	I1x50	4.0475	4	3	8
7	2x40	4.63437	4	3	9
8	2x42	4.372	5	0	8
9	2x46	5.049	5	1	9
10	2x50	5.947	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

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Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x31	1x35	11.7717	4.655	No	No	0	3	5
2	1x35	1x39	20.9674	4.6925	No	Yes	0	5	6
3	1x39	7x39	27.5619	10.47	Yes	Yes	0	6	5
4	7x39	7x42	44.8951	6.5125	Yes	Yes	0	5	6
5	7x42	Lig	53.8074	3.985	Yes	Yes	2	6	0
6	3x36	Lig	37.1355	6.695	No	Yes	0	6	0
7	3x36	6x48	37.6394	7.6625	No	Yes	0	6	8
8	6x48	7x45	75.8456	7.6275	Yes	No	0	8	9
9	7x45	7x49	74.9008	4.4275	No	No	0	9	9
10	2x50	7x49	68.8732	4.375	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
2x56	3x32	10.2225	2	No	No	7	7	2	1
2x56	7x42	4.735	2	No	Yes	7	6	2	1
2x57	7x42	4.1025	0	No	Yes	7	6	2	1
2x59	3x28	7.2675	0	No	Yes	5	5	2	1
3x28	E1x50	9.84	0	Yes	Yes	5	7	1	2
3x28	Lig	3.9025	0	Yes	Yes	5	0	1	0
3x32	7x42	10.6325	2	No	Yes	7	6	1	1
3x32	Lig	14.775	2	No	Yes	7	0	1	0
3x33	4x57	4.8475	0	No	No	5	7	1	2
3x33	Lig	5.9625	0	No	Yes	5	0	1	0
3x36	6x48	7.6625	0	No	Yes	6	8	1	2
3x36	Lig	6.695	0	No	Yes	6	0	1	0
3x37	5x461	7.195	0	No	No	6	5	2	1
E2.T195	E2x52	6.81	0	No	No	3	4	2	1
7x34	E2x52	4.125	2	No	No	5	4	2	1
E2x52	Lig	14.945	0	No	Yes	4	0	1	0
5x39	E2.T195	5.93	4	Yes	No	6	3	2	2
5x39	5x43	9.5375	4	Yes	No	6	5	2	1
5x43	Lig	7.44	0	No	Yes	5	0	1	0
5x44	6x52	3.9625	0	No	Yes	5	7	2	1
5x461	Lig	5.82	0	No	Yes	5	0	1	0
5x47	6x48	3.26	2	Yes	Yes	8	8	2	2
5x47	6x52	15.54	2	Yes	Yes	8	7	2	1
6x48	6x52	6.0125	2	Yes	Yes	8	7	2	1
6x51	6x52	6.4325	2	Yes	Yes	6	7	1	1
6x51	6x55	4.2275	2	Yes	No	6	5	1	1
6x51	7x34	6.19	2	Yes	No	6	5	1	2
6x51	7x37	6.6975	2	Yes	Yes	6	5	1	2
6x51	7x38	16.31	2	Yes	No	6	5	1	1
6x51	Lig	3.8325	2	Yes	Yes	6	0	1	0
6x52	Lig	7.7125	2	Yes	Yes	7	0	1	0
6x55	7x34	8.72	2	No	No	5	5	1	2
6x55	Lig	4.035	2	No	Yes	5	0	1	0
7x38	7x42	6.1075	2	No	Yes	5	6	1	1
7x38	Lig	10.44	2	No	Yes	5	0	1	0
7x39	7x42	6.5125	0	Yes	Yes	5	6	2	1
7x42	Lig	3.985	2	Yes	Yes	6	0	1	0
6x51	7x40	3.7675	2	Yes	No	6	7	1	2
3x28	3x29	2.73	0	Yes	No	5	4	1	2
2x60	3x28	1.76	0	No	Yes	7	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Similarity	Network Type	Name	Ligand	Description
100.00	Single	6KUW	PubChem 57213234	6KUW-α_2c-PubChem 57213234
100.00	Single	6PS3	(S)-Carvedilol	6PS3-β₂-(S)-Carvedilol
100.00	Single	7BVQ	(S)-Carazolol	7BVQ-β₁-(S)-Carazolol
100.00	Single	7S0F	Isoprenaline	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2
100.00	Consensus	alpha2c_off	Orthosteric Ligand	6KUW-α_2c-PubChem 57213234
100.00	Consensus	gi_adrenergic	Orthosteric Ligand	7S0F-β₁-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α_2b-Dexmedetomidine-Gi1/&β;1/&γ;2
92.31	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
92.31	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
91.67	Single	2YCY	Cyanopindolol	2YCY-β₁-Cyanopindolol
91.67	Single	6H7M	Salbutamol	6H7M-β₁-Salbutamol

Consensus Members
	Id	Members
	3SN6	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
	7DHR	7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2
	7BZ2	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
	7DHI	7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2

Net Summary
I_min	3.1
Number of Linked Nodes	286
Number of Links	322
Number of Hubs	43
Number of Links mediated by Hubs	174
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	57191
Length Of Smallest Path	3
Average Path Length	12.3828
Length of Longest Path	28
Minimum Path Strength	0.601667
Average Path Strength	5.20402
Maximum Path Strength	15.5712
Minimum Path Correlation	0.7
Average Path Correlation	0.9327
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	55.0101
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1811
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
	Id	1^st Network	2^nd Network
	beta2_off_on	beta2_off	beta2_on

This network is also present in following consensuses:
	Id	Components
	beta_on	beta1_on beta2_on beta3_on

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta2_on.zip

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