psnGPCR

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Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off Int. Strength	beta2_on Int. Strength	beta2_off Hub1?	beta2_on Hub1?	beta2_off Hub2?	beta2_on Hub2?	ConSurf1	ConSurf2
1	6x48	Lig	beta2_off	100	0	Yes	Yes	Yes	Yes	8	0
2	1x39	2x64	beta2_off	100	0	Yes	No	No	No	6	5
3	1x49	7x50	beta2_off	100	0	No	No	No	No	8	9
4	1x53	7x53	beta2_off	100	0	No	No	Yes	Yes	9	9
5	1x57	2x40	beta2_off	100	0	No	No	No	No	7	9
6	8x49	I1x49	beta2_off	100	0	No	No	No	No	7	6
7	2x38	I2x55	beta2_off	100	0	No	No	No	No	6	4
8	2x39	3x50	beta2_off	100	0	No	No	No	No	8	9
9	2x53	2x56	beta2_off	100	0	Yes	No	No	No	7	7
10	2x53	7x42	beta2_off	100	0	Yes	No	Yes	Yes	7	6
11	2x59	3x24	beta2_off	100	0	No	No	Yes	No	5	5
12	2x63	E1x50	beta2_off	100	0	No	No	Yes	Yes	4	7
13	2x66	E1x51	beta2_off	100	0	No	No	No	No	4	2
14	E1x49	E1x51	beta2_off	100	0	No	No	No	No	5	2
15	3x24	E1x50	beta2_off	100	0	Yes	No	Yes	Yes	5	7
16	3x24	3x27	beta2_off	100	0	Yes	No	Yes	No	5	5
17	3x24	3x28	beta2_off	100	0	Yes	No	Yes	Yes	5	5
18	3x26	4x62	beta2_off	100	0	No	No	No	No	5	4
19	3x27	3x31	beta2_off	100	0	Yes	No	No	No	5	4
20	3x29	E2x52	beta2_off	100	0	No	No	Yes	No	4	4
21	3x30	4x62	beta2_off	100	0	No	No	No	No	6	4
22	3x39	6x44	beta2_off	100	0	No	No	Yes	No	9	9
23	3x43	6x44	beta2_off	100	0	No	No	Yes	No	8	9
24	3x49	3x50	beta2_off	100	0	Yes	No	No	No	8	9
25	3x49	I2x55	beta2_off	100	0	Yes	No	No	No	8	4
26	3x49	I2x57	beta2_off	100	0	Yes	No	No	No	8	7
27	3x50	3x53	beta2_off	100	0	No	No	No	No	9	8
28	3x54	5x64	beta2_off	100	0	No	No	Yes	No	9	5
29	3x55	5x64	beta2_off	100	0	No	No	Yes	No	7	5
30	3x56	I2x51	beta2_off	100	0	No	No	No	No	6	6
31	3x56	I2x56	beta2_off	100	0	No	No	No	No	6	4
32	I2x52	I2x53	beta2_off	100	0	No	No	No	Yes	5	7
33	5x68	I2x52	beta2_off	100	0	No	No	No	No	7	5
34	6x30	I2x53	beta2_off	100	0	No	No	No	Yes	7	7
35	6x31	I2x53	beta2_off	100	0	Yes	No	No	Yes	5	7
36	I2x55	I2x57	beta2_off	100	0	No	No	No	No	4	7
37	4x64	E2.R175	beta2_off	100	0	No	No	No	No	4	2
38	E2.R175	E2.Y174	beta2_off	100	0	No	No	Yes	Yes	2	5
39	E2.Y174	E2x52	beta2_off	100	0	Yes	Yes	Yes	No	5	4
40	E2.A181	E2.H178	beta2_off	100	0	No	No	No	No	4	2
41	E2.A181	E2.Y185	beta2_off	100	0	No	No	No	Yes	4	1
42	E2.C184	E2x51	beta2_off	100	0	No	No	Yes	No	1	3
43	E2.C184	E2.F194	beta2_off	100	0	No	No	Yes	No	1	1
44	E2.E187	E2.T189	beta2_off	100	0	No	No	No	No	4	4
45	5x51	6x45	beta2_off	100	0	No	No	No	No	7	7
46	5x58	5x61	beta2_off	100	0	Yes	Yes	No	No	9	8
47	5x58	5x62	beta2_off	100	0	Yes	Yes	No	Yes	9	6
48	5x58	6x34	beta2_off	100	0	Yes	Yes	No	No	9	7
49	5x58	6x41	beta2_off	100	0	Yes	Yes	No	No	9	8
50	5x62	6x26	beta2_off	100	0	No	Yes	No	No	6	4
51	5x65	6x31	beta2_off	100	0	No	No	Yes	No	8	5
52	5x66	6x25	beta2_off	100	0	No	No	No	No	6	2
53	5x69	6x31	beta2_off	100	0	No	No	Yes	No	5	5
54	6x26	6x35	beta2_off	100	0	No	No	No	No	4	7
55	6x28	6x30	beta2_off	100	0	No	No	No	No	5	7
56	6x28	6x31	beta2_off	100	0	No	No	Yes	No	5	5
57	6x29	6x30	beta2_off	100	0	No	No	No	No	6	7
58	6x35	7x55	beta2_off	100	0	No	No	No	No	7	7
59	6x36	7x55	beta2_off	100	0	No	No	No	No	8	7
60	6x39	7x52	beta2_off	100	0	No	No	No	No	7	8
61	6x40	7x49	beta2_off	100	0	No	No	No	Yes	8	9
62	6x40	7x52	beta2_off	100	0	No	No	No	No	8	8
63	6x44	6x48	beta2_off	100	0	Yes	No	Yes	Yes	9	8
64	6x44	7x45	beta2_off	100	0	Yes	No	No	Yes	9	9
65	7x43	7x48	beta2_off	100	0	No	No	No	No	5	6
66	7x49	7x53	beta2_off	100	0	No	Yes	Yes	Yes	9	9
67	7x53	8x50	beta2_off	100	0	Yes	Yes	Yes	Yes	9	9
68	8x48	8x51	beta2_off	100	0	No	No	No	No	5	9
69	8x58	CT.L342	beta2_off	100	0	No	No	No	No	6	8
70	5x64	5x68	beta2_off	100	0	Yes	No	No	No	5	7
71	6x61	E3.N301	beta2_off	100	0	No	No	No	No	2	2
72	5x67	5x68	beta2_off	100	0	No	No	No	No	4	7
73	5x60	5x63	beta2_off	14.2857	0	Yes	No	No	No	5	3
74	5x36	5x39	beta2_off	28.5714	0	No	No	Yes	Yes	4	6
75	6x25	6x26	beta2_off	28.5714	0	No	No	No	No	2	4
76	5x58	6x38	beta2_off	28.5714	0	Yes	Yes	No	No	9	6
77	1x60	8x57	beta2_off	42.8571	0	Yes	Yes	No	No	6	6
78	1x52	8x57	beta2_off	28.5714	0	No	No	No	No	6	6
79	E2.A176	E2.H178	beta2_off	14.2857	0	No	No	No	No	1	2
80	1x50	2x47	beta2_off	42.8571	0	No	No	No	No	9	9
81	8x55	CT.L342	beta2_off	14.2857	0	No	No	No	No	4	8
82	I2x51	I2x54	beta2_off	28.5714	0	No	No	No	No	6	4
83	2x41	I1x51	beta2_off	28.5714	0	No	No	No	No	4	8
84	3x52	I2x56	beta2_off	28.5714	0	No	No	No	No	5	4
85	2x62	E1x52	beta2_off	0	0	No	No	Yes	Yes	4	5
86	1x32	2x65	beta2_off	14.2857	0	No	No	No	No	4	6
87	3x23	3x27	beta2_off	28.5714	0	No	No	Yes	No	1	5
88	6x47	7x48	beta2_off	0	0	No	No	No	No	9	6
89	6x47	7x40	beta2_off	0	0	No	No	No	No	9	7
90	1x37	1x41	beta2_off	14.2857	0	No	No	No	No	5	5
91	6x51	7x37	beta2_off	0	0	Yes	Yes	Yes	Yes	6	5
92	1x54	2x51	beta2_off	0	0	No	No	No	No	7	7
93	3x21	E2.E188	beta2_off	0	0	No	No	No	No	7	3
94	1x39	2x65	beta2_off	14.2857	0	Yes	No	No	No	6	6
95	1x56	8x53	beta2_off	0	0	No	No	No	No	8	7
96	3x34	4x54	beta2_off	0	0	No	Yes	No	No	5	4
97	5x40	6x59	beta2_off	0	0	No	No	Yes	No	5	5
98	I1x48	I1x49	beta2_off	14.2857	0	No	No	No	No	6	6
99	3x45	4x49	beta2_off	0	0	No	No	No	No	7	7
100	6x53	6x57	beta2_off	0	0	No	No	No	No	6	4
101	5x54	5x55	beta2_off	0	0	No	No	No	No	8	5
102	1x28	1x29	beta2_off	14.2857	0	No	No	No	No	5	3
103	1x31	2x67	beta2_off	14.2857	0	No	No	No	No	3	4
104	2x52	2x551	beta2_off	0	0	No	No	No	No	7	4
105	4x56	4x57	beta2_off	0	0	No	No	No	Yes	5	7
106	1x33	1x34	beta2_off	0	0	No	No	No	No	5	5
107	1x44	1x48	beta2_off	14.2857	0	No	No	No	No	5	4
108	3x41	4x52	beta2_off	14.2857	0	No	No	No	No	5	4
109	1x28	1x30	beta2_off	14.2857	0	No	No	No	No	5	2
110	E2.I182	E2.Q179	beta2_off	0	0	No	No	No	No	1	3
111	5x59	5x63	beta2_off	0	0	No	No	No	No	3	3
112	1x29	1x33	beta2_off	0	0	No	No	No	No	3	5
113	E2.E187	E2.N183	beta2_off	0	0	No	No	No	No	4	3
114	7x48	7x51	beta2_off	0	0	No	No	No	No	6	6
115	1x36	1x40	beta2_off	0	0	No	No	No	No	5	4
116	1x58	1x59	beta2_off	0	0	No	No	No	No	4	5
117	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
118	3x33	Lig	Shared	100	100	No	No	Yes	Yes	5	0
119	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
120	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
121	5x43	Lig	Shared	100	100	No	No	Yes	Yes	5	0
122	5x461	Lig	Shared	100	100	No	No	Yes	Yes	5	0
123	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
124	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
125	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
126	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
127	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
128	1x31	1x35	Shared	100	100	No	No	No	No	3	5
129	1x39	2x61	Shared	100	50	Yes	No	No	No	6	6
130	1x39	7x39	Shared	100	100	Yes	No	No	Yes	6	5
131	1x43	2x58	Shared	100	100	No	No	No	No	6	8
132	1x46	2x54	Shared	100	100	No	No	No	No	8	7
133	1x46	7x46	Shared	100	100	No	No	No	No	8	9
134	1x47	2x55	Shared	100	0	No	No	No	No	6	5
135	1x50	2x50	Shared	100	100	No	No	No	Yes	9	9
136	1x50	7x50	Shared	100	100	No	No	No	No	9	9
137	1x52	8x54	Shared	100	100	No	No	No	Yes	6	7
138	1x52	8x58	Shared	100	0	No	No	No	No	6	6
139	1x55	8x57	Shared	100	0	No	No	No	No	5	6
140	1x57	2x44	Shared	100	100	No	No	No	No	7	6
141	1x57	8x50	Shared	100	100	No	No	Yes	Yes	7	9
142	1x59	1x60	Shared	100	100	No	No	Yes	Yes	5	6
143	1x60	8x53	Shared	100	100	Yes	Yes	No	No	6	7
144	1x60	8x56	Shared	100	100	Yes	Yes	No	No	6	4
145	8x50	I1x50	Shared	100	100	Yes	Yes	No	No	9	8
146	2x37	2x40	Shared	100	100	No	No	No	No	7	9
147	2x40	8x50	Shared	100	100	No	No	Yes	Yes	9	9
148	2x41	4x39	Shared	100	100	No	No	No	No	4	1
149	2x41	4x43	Shared	100	50	No	No	No	No	4	3
150	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
151	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
152	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	8
153	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
154	2x43	7x53	Shared	100	0	No	No	Yes	Yes	8	9
155	2x45	3x42	Shared	100	100	No	No	No	No	9	8
156	2x45	4x46	Shared	100	100	No	No	No	No	9	8
157	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
158	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
159	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
160	2x51	2x55	Shared	100	0	No	No	No	No	7	5
161	2x53	3x35	Shared	100	100	Yes	No	No	No	7	7
162	2x53	7x46	Shared	100	100	Yes	No	No	No	7	9
163	2x56	3x32	Shared	100	100	No	No	No	No	7	7
164	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	6
165	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	6
166	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	5	5
167	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
168	2x64	7x39	Shared	100	50	No	No	No	Yes	5	5
169	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
170	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
171	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	7
172	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
173	E1x51	E1x52	Shared	100	50	No	No	Yes	Yes	2	5
174	3x24	E1x52	Shared	100	50	Yes	No	Yes	Yes	5	5
175	3x22	E2.E188	Shared	100	100	No	No	No	No	2	3
176	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
177	3x26	4x64	Shared	100	100	No	No	No	No	5	4
178	3x27	4x58	Shared	100	50	Yes	No	No	Yes	5	4
179	3x30	4x58	Shared	100	100	No	No	No	Yes	6	4
180	3x30	4x61	Shared	100	100	No	No	No	No	6	5
181	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	6
182	3x33	4x57	Shared	100	100	No	No	No	Yes	5	7
183	3x34	4x50	Shared	100	100	No	Yes	Yes	Yes	5	9
184	3x34	4x57	Shared	100	100	No	Yes	No	Yes	5	7
185	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
186	3x37	4x53	Shared	100	100	No	No	No	No	6	8
187	3x37	5x461	Shared	100	100	No	No	No	No	6	5
188	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
189	3x40	5x50	Shared	100	100	No	No	Yes	Yes	7	8
190	3x40	6x44	Shared	100	100	No	No	Yes	No	7	9
191	3x44	5x50	Shared	100	100	No	No	Yes	Yes	7	8
192	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
193	3x51	5x60	Shared	100	100	Yes	Yes	Yes	No	8	5
194	4x41	I2x57	Shared	100	50	No	No	No	No	5	7
195	4x38	4x41	Shared	100	100	No	No	No	No	8	5
196	4x58	4x62	Shared	100	100	No	Yes	No	No	4	4
197	4x60	E2.W173	Shared	100	50	No	No	No	No	5	4
198	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	6
199	4x61	E2.Y174	Shared	100	100	No	No	Yes	Yes	5	5
200	4x63	E2.W173	Shared	100	100	No	No	No	No	4	4
201	E2.Y174	E2.Y185	Shared	100	100	Yes	Yes	No	Yes	5	1
202	5x39	E2.Y174	Shared	100	100	Yes	Yes	Yes	Yes	6	5
203	E2.R175	E2.Y185	Shared	100	100	No	No	No	Yes	2	1
204	E2.E180	E2.H178	Shared	100	100	No	No	No	No	3	2
205	E2.N183	E2.Q179	Shared	100	100	No	No	No	No	3	3
206	E2.E180	E2.F194	Shared	100	100	No	No	Yes	No	3	1
207	E2.A181	E2.F194	Shared	100	100	No	No	Yes	No	4	1
208	E2.C184	E2.C190	Shared	100	100	No	No	No	No	1	3
209	E2.C190	E2x51	Shared	100	100	No	No	Yes	No	3	3
210	E2.F194	E2x51	Shared	100	100	Yes	No	Yes	No	1	3
211	7x31	E2x51	Shared	100	100	No	No	Yes	No	2	3
212	E2.T195	E2x52	Shared	100	100	No	No	Yes	No	3	4
213	5x39	E2.T195	Shared	100	100	Yes	Yes	No	No	6	3
214	5x37	6x59	Shared	100	100	No	No	Yes	No	2	5
215	5x39	5x43	Shared	100	100	Yes	Yes	No	No	6	5
216	5x41	6x59	Shared	100	100	No	No	Yes	No	5	5
217	5x44	6x52	Shared	100	100	No	No	Yes	Yes	5	7
218	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	8	5
219	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	7
220	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
221	5x48	6x56	Shared	100	100	No	Yes	No	No	5	6
222	5x54	6x41	Shared	100	100	No	No	No	No	8	8
223	5x58	6x37	Shared	100	100	Yes	Yes	No	Yes	9	8
224	5x64	5x67	Shared	100	0	Yes	No	No	No	5	4
225	6x39	7x55	Shared	100	100	No	No	No	No	7	7
226	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
227	6x47	7x45	Shared	100	100	No	No	No	Yes	9	9
228	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	6
229	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
230	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
231	6x49	6x53	Shared	100	50	No	Yes	No	No	6	6
232	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	7
233	6x51	7x34	Shared	100	100	Yes	Yes	No	No	6	5
234	6x51	7x38	Shared	100	100	Yes	Yes	No	No	6	5
235	6x54	E3.I303	Shared	100	100	No	No	No	No	5	3
236	6x55	7x34	Shared	100	100	No	No	No	No	5	5
237	6x58	E3.I303	Shared	100	50	No	No	No	No	3	3
238	7x30	7x32	Shared	100	0	No	No	No	No	4	2
239	7x30	7x33	Shared	100	0	No	No	No	No	4	4
240	7x31	7x35	Shared	100	50	No	No	No	No	2	3
241	7x38	7x42	Shared	100	100	No	No	Yes	Yes	5	6
242	7x39	7x42	Shared	100	100	No	Yes	Yes	Yes	5	6
243	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
244	8x50	8x54	Shared	100	100	Yes	Yes	No	Yes	9	7
245	3x41	5x50	Shared	100	100	No	No	Yes	Yes	5	8
246	5x60	5x64	Shared	100	50	Yes	No	Yes	No	5	5
247	1x51	2x51	Shared	42.8571	0	No	No	No	No	3	7
248	6x54	7x37	Shared	57.1429	100	No	No	Yes	Yes	5	5
249	3x56	I2x50	Shared	42.8571	0	No	No	No	No	6	8
250	8x47	8x48	Shared	42.8571	100	No	No	No	No	8	5
251	2x46	7x49	Shared	42.8571	100	No	Yes	No	Yes	9	9
252	5x49	5x50	Shared	42.8571	100	No	No	Yes	Yes	5	8
253	3x47	5x58	Shared	42.8571	100	No	No	Yes	Yes	8	9
254	2x52	3x35	Shared	14.2857	100	No	No	No	No	7	7
255	3x44	5x53	Shared	14.2857	100	No	No	No	No	7	6
256	E2.C190	E2.E187	Shared	14.2857	0	No	No	No	No	3	4
257	1x54	2x47	Shared	14.2857	100	No	No	No	No	7	9
258	1x35	1x39	Shared	28.5714	0	No	No	Yes	No	5	6
259	3x45	4x45	Shared	0	0	No	No	No	No	7	6
260	1x43	2x57	Shared	0	100	No	No	No	No	6	7
261	3x51	3x52	Shared	42.8571	100	Yes	Yes	No	No	8	5
262	4x40	4x43	Shared	57.1429	50	No	No	No	No	4	3
263	6x43	7x45	Shared	28.5714	50	No	No	No	Yes	6	9
264	5x56	5x60	Shared	28.5714	50	No	No	Yes	No	4	5
265	6x50	7x37	Shared	28.5714	50	No	No	Yes	Yes	9	5
266	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	7	7
267	7x54	8x54	Shared	0	100	No	No	No	Yes	7	7
268	1x36	2x65	Shared	0	50	No	No	No	No	5	6
269	8x52	I1x49	Shared	28.5714	0	No	No	No	No	4	6
270	2x38	4x42	Shared	14.2857	0	No	No	No	No	6	7
271	6x61	E3.L302	Shared	28.5714	100	No	No	No	No	2	1
272	3x54	5x61	Shared	28.5714	50	No	No	No	No	9	8
273	3x48	3x52	Shared	0	0	No	No	No	No	6	5
274	5x47	6x49	Shared	14.2857	100	Yes	Yes	No	Yes	8	6
275	2x60	3x28	Shared	14.2857	0	No	No	Yes	Yes	7	5
276	2x49	4x50	Shared	0	0	No	No	Yes	Yes	8	9
277	3x51	5x57	Shared	14.2857	100	Yes	Yes	No	No	8	6
278	8x47	8x49	Shared	14.2857	50	No	No	No	No	8	7
279	6x58	E3.D300	Shared	28.5714	100	No	No	No	No	3	1
280	1x46	7x47	Shared	14.2857	100	No	No	No	No	8	7
281	E3.D300	E3.N301	Shared	28.5714	100	No	No	No	No	1	2
282	1x48	1x49	Shared	28.5714	100	No	No	No	No	4	8
283	6x42	6x45	Shared	0	0	No	No	No	No	5	7
284	5x41	5x45	Shared	0	0	No	No	No	No	5	4
285	1x42	7x43	Shared	28.5714	100	No	No	No	No	6	5
286	7x33	7x37	Shared	0	0	No	No	Yes	Yes	4	5
287	5x36	5x38	Shared	0	50	No	No	No	No	4	4
288	4x55	4x59	Shared	42.8571	0	No	No	No	No	4	5
289	4x59	4x60	Shared	14.2857	50	No	No	No	No	5	5
290	1x54	2x48	Shared	14.2857	0	No	No	No	No	7	6
291	1x33	1x37	Shared	0	0	No	No	No	No	5	5
292	5x40	E2.T195	Shared	0	100	No	No	No	No	5	3
293	I1x48	I1x51	Shared	0	100	No	No	No	No	6	8
294	1x38	1x42	Shared	0	0	No	No	No	No	5	6
295	4x48	4x52	Shared	0	0	No	No	No	No	4	4
296	4x47	4x51	Shared	14.2857	0	No	No	No	No	3	4
297	4x44	4x48	Shared	0	0	No	No	No	No	4	4
298	4x51	4x55	Shared	0	0	No	No	No	No	4	4
299	6x59	6x60	Shared	0	50	Yes	No	No	No	5	4
300	1x30	1x31	Shared	14.2857	50	No	No	No	No	2	3
301	4x56	5x46	Shared	0	100	No	No	No	No	5	4
302	7x36	7x40	Shared	0	0	No	No	No	No	5	7
303	1x29	1x31	beta2_on	0	100	No	No	No	No	3	3
304	1x29	1x32	beta2_on	0	100	No	No	No	No	3	4
305	1x53	2x47	beta2_on	0	100	No	No	No	No	9	9
306	1x53	7x54	beta2_on	0	100	No	No	No	No	9	7
307	1x57	I1x51	beta2_on	0	100	No	No	No	No	7	8
308	1x60	I1x49	beta2_on	0	100	Yes	Yes	No	No	6	6
309	2x39	3x49	beta2_on	0	100	No	No	Yes	No	8	8
310	2x46	2x50	beta2_on	0	100	No	Yes	No	Yes	9	9
311	2x46	3x42	beta2_on	0	100	No	Yes	No	No	9	8
312	2x50	7x49	beta2_on	0	100	No	Yes	No	Yes	9	9
313	2x52	3x31	beta2_on	0	100	No	No	No	No	7	4
314	2x53	3x36	beta2_on	0	100	Yes	No	No	No	7	6
315	2x57	7x39	beta2_on	0	100	No	No	No	Yes	7	5
316	E1x49	E2.T189	beta2_on	0	100	No	No	No	No	5	4
317	3x26	E2.Y174	beta2_on	0	100	No	No	Yes	Yes	5	5
318	3x28	Lig	beta2_on	0	100	Yes	Yes	Yes	Yes	5	0
319	3x34	4x53	beta2_on	0	100	No	Yes	No	No	5	8
320	3x34	4x58	beta2_on	0	100	No	Yes	No	Yes	5	4
321	3x37	4x56	beta2_on	0	100	No	No	No	No	6	5
322	3x38	4x53	beta2_on	0	100	No	No	No	No	7	8
323	3x40	6x48	beta2_on	0	100	No	No	Yes	Yes	7	8
324	3x43	7x49	beta2_on	0	100	No	No	No	Yes	8	9
325	3x43	7x53	beta2_on	0	100	No	No	Yes	Yes	8	9
326	3x46	3x50	beta2_on	0	100	No	No	No	No	9	9
327	3x49	I2x53	beta2_on	0	100	Yes	No	No	Yes	8	7
328	3x50	5x58	beta2_on	0	100	No	No	Yes	Yes	9	9
329	3x50	7x53	beta2_on	0	100	No	No	Yes	Yes	9	9
330	3x53	I2x53	beta2_on	0	100	No	No	No	Yes	8	7
331	3x56	I2x52	beta2_on	0	100	No	No	No	No	6	5
332	I2x53	I2x57	beta2_on	0	100	No	Yes	No	No	7	7
333	4x57	4x58	beta2_on	0	100	No	Yes	No	Yes	7	4
334	4x64	E2.Y185	beta2_on	0	100	No	No	No	Yes	4	1
335	5x36	E2.R175	beta2_on	0	100	No	No	No	No	4	2
336	E2.A176	E2.Y185	beta2_on	0	100	No	No	No	Yes	1	1
337	E2.H178	E2.Q179	beta2_on	0	100	No	No	No	No	2	3
338	E2.E180	E2.Q179	beta2_on	0	100	No	No	No	No	3	3
339	E2.C184	E2.N183	beta2_on	0	100	No	No	No	No	1	3
340	E2.E188	E2.T189	beta2_on	0	100	No	No	No	No	3	4
341	5x47	6x44	beta2_on	0	100	Yes	Yes	Yes	No	8	9
342	5x48	6x52	beta2_on	0	100	No	Yes	Yes	Yes	5	7
343	5x54	6x44	beta2_on	0	100	No	No	Yes	No	8	9
344	5x58	6x40	beta2_on	0	100	Yes	Yes	No	No	9	8
345	5x62	6x34	beta2_on	0	100	No	Yes	No	No	6	7
346	5x62	6x37	beta2_on	0	100	No	Yes	No	Yes	6	8
347	5x69	6x29	beta2_on	0	100	No	No	No	No	5	6
348	I3.F240	I3.R239	beta2_on	0	100	No	No	No	No	0	0
349	6x27	6x30	beta2_on	0	100	No	No	No	No	3	7
350	6x31	6x35	beta2_on	0	100	Yes	No	No	No	5	7
351	6x48	7x45	beta2_on	0	100	Yes	Yes	No	Yes	8	9
352	6x49	6x50	beta2_on	0	100	No	Yes	No	No	6	9
353	6x51	6x55	beta2_on	0	100	Yes	Yes	No	No	6	5
354	7x45	7x49	beta2_on	0	100	No	Yes	No	Yes	9	9
355	7x52	7x53	beta2_on	0	100	No	No	Yes	Yes	8	9
356	7x54	8x50	beta2_on	0	100	No	No	Yes	Yes	7	9
357	7x55	8x51	beta2_on	0	100	No	No	No	No	7	9
358	2x59	E1x50	beta2_on	0	100	No	No	Yes	Yes	5	7
359	E2.I182	E2.R175	beta2_on	0	100	No	No	No	No	1	2
360	5x67	5x71	beta2_on	0	100	No	No	No	No	4	0
361	1x60	I1x50	beta2_on	0	50	Yes	Yes	No	No	6	8
362	3x28	3x29	beta2_on	0	50	Yes	Yes	No	No	5	4
363	6x45	6x49	beta2_on	0	0	No	No	No	Yes	7	6
364	2x63	Lig	beta2_on	0	50	No	No	Yes	Yes	4	0
365	2x50	3x39	beta2_on	0	0	No	Yes	No	No	9	9
366	2x64	7x35	beta2_on	0	0	No	No	No	No	5	3
367	5x73	I3.V242	beta2_on	0	50	No	No	No	No	0	0
368	I2x52	I2x56	beta2_on	0	50	No	No	No	No	5	4
369	5x68	5x71	beta2_on	0	50	No	No	No	No	7	0
370	1x53	7x50	beta2_on	0	50	No	No	No	No	9	9
371	1x48	1x52	beta2_on	0	0	No	No	No	No	4	6
372	1x42	7x39	beta2_on	0	0	No	No	No	Yes	6	5
373	3x22	E2.A186	beta2_on	0	50	No	No	No	No	2	1
374	6x57	E3.I303	beta2_on	0	50	No	No	No	No	4	3
375	2x38	4x39	beta2_on	0	50	No	No	No	No	6	1
376	6x57	E3.L302	beta2_on	0	50	No	No	No	No	4	1
377	5x75	5x76	beta2_on	0	50	No	No	No	No	0	0
378	6x32	6x35	beta2_on	0	50	No	No	No	No	7	7
379	1x59	8x57	beta2_on	0	50	No	No	No	No	5	6
380	1x56	8x54	beta2_on	0	0	No	No	No	Yes	8	7
381	E2.H178	E2.T177	beta2_on	0	50	No	No	No	No	2	3
382	3x22	3x26	beta2_on	0	50	No	No	No	No	2	5
383	6x43	7x48	beta2_on	0	50	No	No	No	No	6	6
384	5x57	5x58	beta2_on	0	0	No	No	Yes	Yes	6	9
385	7x52	7x55	beta2_on	0	50	No	No	No	No	8	7
386	4x54	4x57	beta2_on	0	0	No	No	No	Yes	4	7
387	5x62	5x66	beta2_on	0	50	No	Yes	No	No	6	6
388	5x45	5x48	beta2_on	0	0	No	No	No	Yes	4	5
389	5x62	5x63	beta2_on	0	50	No	Yes	No	No	6	3
390	3x53	3x54	beta2_on	0	0	No	No	No	No	8	9
391	3x55	3x56	beta2_on	0	50	No	No	No	No	7	6
392	1x51	1x55	beta2_on	0	0	No	No	No	No	3	5
393	3x42	4x49	beta2_on	0	0	No	No	No	No	8	7
394	2x66	E1x49	beta2_on	0	0	No	No	No	No	4	5
395	5x55	6x41	beta2_on	0	0	No	No	No	No	5	8
396	4x41	4x44	beta2_on	0	0	No	No	No	No	5	4
397	I2x55	I2x56	beta2_on	0	0	No	No	No	No	4	4
398	6x32	6x36	beta2_on	0	0	No	No	No	No	7	8
399	2x38	I2x57	beta2_on	0	0	No	No	No	No	6	7
400	6x36	6x37	beta2_on	0	0	No	No	No	Yes	8	8
401	7x37	7x40	beta2_on	0	0	Yes	Yes	No	No	5	7
402	1x35	2x65	beta2_on	0	0	No	No	No	No	5	6
403	5x72	5x73	beta2_on	0	0	No	No	No	No	0	0
404	5x72	5x76	beta2_on	0	0	No	No	No	No	0	0
405	8x52	8x55	beta2_on	0	0	No	No	No	No	4	4
406	5x76	I3.R239	beta2_on	0	0	No	No	No	No	0	0
407	I2x53	I2x54	beta2_on	0	0	No	Yes	No	No	7	4
408	3x23	3x24	beta2_on	0	0	No	No	Yes	No	1	5
409	I3.G238	I3.V242	beta2_on	0	0	No	No	No	No	0	0
410	5x65	6x33	beta2_on	0	0	No	No	No	No	8	8
411	1x34	1x37	beta2_on	0	0	No	No	No	No	5	5
412	6x37	6x38	beta2_on	0	0	No	Yes	No	No	8	6
413	5x55	5x59	beta2_on	0	0	No	No	No	No	5	3
414	8x58	8x59	beta2_on	0	0	No	No	No	No	6	5
415	5x69	6x33	beta2_on	0	0	No	No	No	No	5	8
416	1x37	1x38	beta2_on	0	0	No	No	No	No	5	5
417	6x29	6x32	beta2_on	0	0	No	No	No	No	6	7
418	7x51	7x52	beta2_on	0	0	No	No	No	No	6	8
419	5x66	6x30	beta2_on	0	0	No	No	No	No	6	7
420	5x70	5x73	beta2_on	0	0	No	No	No	No	0	0
421	I2x51	I2x52	beta2_on	0	0	No	No	No	No	6	5

Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta2_off Avg Int. Strength	beta2_on Avg Int. Strength	beta2_off Num Of Links	beta2_on Num Of Links	ConSurf
1	1x39	beta2_off	28.5714	0	5	3	6
2	2x53	beta2_off	28.5714	50	4	3	7
3	3x24	beta2_off	100	0	5	2	5
4	3x27	beta2_off	28.5714	0	4	1	5
5	3x49	beta2_off	57.1429	0	4	3	8
6	E2x51	beta2_off	28.5714	50	4	3	3
7	E2x52	beta2_off	57.1429	0	4	2	4
8	E2.F194	beta2_off	85.7143	0	4	3	1
9	5x60	beta2_off	0	0	4	3	5
10	5x64	beta2_off	85.7143	0	5	2	5
11	6x31	beta2_off	42.8571	0	4	1	5
12	6x44	beta2_off	100	50	5	3	9
13	6x59	beta2_off	0	0	4	3	5
14	Lig	Shared	100	100	12	13	0
15	1x60	Shared	0	50	4	5	6
16	2x42	Shared	71.4286	0	4	4	8
17	E1x50	Shared	100	100	7	6	7
18	E1x52	Shared	71.4286	0	5	4	5
19	3x28	Shared	57.1429	50	4	5	5
20	3x51	Shared	14.2857	50	4	4	8
21	4x50	Shared	0	0	4	4	9
22	E2.Y174	Shared	85.7143	50	5	4	5
23	5x39	Shared	85.7143	100	5	4	6
24	5x47	Shared	14.2857	100	4	5	8
25	5x50	Shared	42.8571	100	4	4	8
26	5x58	Shared	100	100	7	5	9
27	6x48	Shared	85.7143	100	6	6	8
28	6x51	Shared	85.7143	100	6	6	6
29	6x52	Shared	85.7143	100	5	6	7
30	7x37	Shared	0	0	4	4	5
31	7x42	Shared	100	100	7	6	6
32	7x53	Shared	100	50	5	5	9
33	8x50	Shared	100	100	6	6	9
34	2x46	beta2_on	0	0	2	4	9
35	2x50	beta2_on	0	100	2	5	9
36	3x34	beta2_on	0	0	3	4	5
37	I2x53	beta2_on	28.5714	0	3	4	7
38	4x57	beta2_on	0	0	3	4	7
39	4x58	beta2_on	14.2857	0	3	5	4
40	E2.Y185	beta2_on	0	50	3	4	1
41	5x48	beta2_on	0	0	2	4	5
42	5x62	beta2_on	0	0	2	4	6
43	6x37	beta2_on	0	0	1	4	8
44	6x49	beta2_on	0	0	2	4	6
45	7x39	beta2_on	28.5714	50	3	5	5
46	7x45	beta2_on	0	50	3	4	9
47	7x49	beta2_on	28.5714	50	3	4	9
48	8x54	beta2_on	0	0	3	4	7

Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off Recurrence	beta2_on Recurrence	beta2_off Hub1?	beta2_on Hub1?	beta2_off Hub2?	beta2_on Hub2?	ConSurf1	ConSurf2
1	E2x52	Lig	beta2_off	64.0186	3.86153	Yes	No	Yes	Yes	4	0
2	6x48	Lig	beta2_off	85.0215	0	Yes	Yes	Yes	Yes	8	0
3	1x31	1x35	beta2_off	12.5937	6.6139	No	No	No	No	3	5
4	2x53	7x42	beta2_off	29.707	0	Yes	No	Yes	Yes	7	6
5	1x50	2x47	beta2_off	10.459	0	No	No	No	No	9	9
6	1x52	8x54	beta2_off	16.4184	5.35137	No	No	No	Yes	6	7
7	8x50	8x54	beta2_off	19.0981	0.457359	Yes	Yes	No	Yes	9	7
8	7x53	8x50	beta2_off	40.5109	0	Yes	Yes	Yes	Yes	9	9
9	7x49	7x53	beta2_off	34.2216	0	No	Yes	Yes	Yes	9	9
10	2x46	7x49	beta2_off	89.996	5.99496	No	Yes	No	Yes	9	9
11	3x43	6x44	beta2_off	91.0759	0	No	No	Yes	No	8	9
12	6x44	6x48	beta2_off	100	0	Yes	No	Yes	Yes	9	8
13	1x52	8x57	beta2_off	11.1639	0	No	No	No	No	6	6
14	8x47	8x50	beta2_off	16.3434	3.22616	No	No	Yes	Yes	8	9
15	8x47	8x49	beta2_off	12.2788	1.07904	No	No	No	No	8	7
16	8x49	I1x49	beta2_off	10.9039	0	No	No	No	No	7	6
17	3x34	4x57	beta2_off	30.252	9.27316	No	Yes	No	Yes	5	7
18	3x24	3x27	beta2_off	22.1878	0	Yes	No	Yes	No	5	5
19	3x27	4x58	beta2_off	26.1624	0.777784	Yes	No	No	Yes	5	4
20	3x30	4x58	beta2_off	27.0923	5.09941	No	No	No	Yes	6	4
21	3x30	4x61	beta2_off	29.587	4.43392	No	No	No	No	6	5
22	4x61	E2.Y174	beta2_off	30.8519	4.65849	No	No	Yes	Yes	5	5
23	E2.Y174	E2x52	beta2_off	56.7643	0	Yes	Yes	Yes	No	5	4
24	3x24	E1x50	beta2_off	10.004	0	Yes	No	Yes	Yes	5	7
25	3x40	6x44	beta2_off	12.7287	3.14126	No	No	Yes	No	7	9
26	3x40	5x50	beta2_off	11.3539	7.80249	No	No	Yes	Yes	7	8
27	6x40	7x49	beta2_off	55.1645	0	No	No	No	Yes	8	9
28	6x40	7x52	beta2_off	63.7136	0	No	No	No	No	8	8
29	6x39	7x52	beta2_off	62.7887	0	No	No	No	No	7	8
30	6x39	7x55	beta2_off	61.8288	1.56652	No	No	No	No	7	7
31	6x35	7x55	beta2_off	59.914	0	No	No	No	No	7	7
32	6x26	6x35	beta2_off	59.1341	0	No	No	No	No	4	7
33	5x62	6x26	beta2_off	56.1494	0	No	Yes	No	No	6	4
34	5x58	5x62	beta2_off	55.3295	0	Yes	Yes	No	Yes	9	6
35	5x58	5x61	beta2_off	46.9303	0	Yes	Yes	No	No	9	8
36	3x54	5x61	beta2_off	45.8354	0.964014	No	No	No	No	9	8
37	3x54	5x64	beta2_off	44.7305	0	No	No	Yes	No	9	5
38	3x55	5x64	beta2_off	13.4637	0	No	No	Yes	No	7	5
39	3x51	3x52	beta2_off	19.0681	5.4527	Yes	Yes	No	No	8	5
40	3x52	I2x56	beta2_off	13.6686	0	No	No	No	No	5	4
41	3x56	I2x56	beta2_off	10.9539	0	No	No	No	No	6	4
42	5x64	5x68	beta2_off	13.8086	0	Yes	No	No	No	5	7
43	5x68	I2x52	beta2_off	12.4938	0	No	No	No	No	7	5
44	I2x52	I2x53	beta2_off	11.1189	0	No	No	No	Yes	5	7
45	E2.A181	E2.Y185	beta2_off	30.352	0	No	No	No	Yes	4	1
46	E2.A181	E2.F194	beta2_off	25.0525	1.65964	No	No	Yes	No	4	1
47	E2.C190	E2.E187	beta2_off	14.3686	1.66511	No	No	No	No	3	4
48	E2.F194	E2x51	beta2_off	12.5937	9.67026	Yes	No	Yes	No	1	3
49	5x40	E2.T195	beta2_off	10.074	1.39946	No	No	No	No	5	3
50	6x44	7x45	beta2_off	14.0936	0	Yes	No	No	Yes	9	9
51	6x47	7x45	beta2_off	11.3539	1.53092	No	No	No	Yes	9	9
52	6x51	7x37	beta2_off	19.4931	0	Yes	Yes	Yes	Yes	6	5
53	6x54	7x37	beta2_off	11.5438	7.84083	No	No	Yes	Yes	5	5
54	3x33	Lig	Shared	35.0915	12.2857	No	No	Yes	Yes	5	0
55	5x43	Lig	Shared	12.0588	30.9826	No	No	Yes	Yes	5	0
56	6x51	Lig	Shared	10.294	23.517	Yes	Yes	Yes	Yes	6	0
57	1x35	1x39	Shared	14.0236	11.423	No	No	Yes	No	5	6
58	1x39	7x39	Shared	21.7278	14.5588	Yes	No	No	Yes	6	5
59	7x39	7x42	Shared	24.3926	46.7738	No	Yes	Yes	Yes	5	6
60	2x53	7x46	Shared	24.5575	15.4626	Yes	No	No	No	7	9
61	1x50	2x50	Shared	17.6332	37.1775	No	No	No	Yes	9	9
62	2x50	7x46	Shared	19.0381	16.076	No	Yes	No	No	9	9
63	2x46	3x43	Shared	90.5409	11.7873	No	Yes	No	No	9	8
64	2x42	3x49	Shared	13.5436	18.3683	Yes	Yes	Yes	No	8	8
65	2x42	4x46	Shared	20.093	19.283	Yes	Yes	No	No	8	8
66	2x45	4x46	Shared	21.3979	19.7924	No	No	No	No	9	8
67	2x45	4x50	Shared	23.9776	16.3417	No	No	Yes	Yes	9	9
68	3x34	4x50	Shared	27.7722	15.3092	No	Yes	Yes	Yes	5	9
69	3x33	4x57	Shared	33.8966	11.2395	No	No	No	Yes	5	7
70	3x51	3x55	Shared	12.1638	18.9955	Yes	Yes	No	No	8	7
71	5x60	5x64	Shared	17.4983	10.8862	Yes	No	Yes	No	5	5
72	3x51	5x60	Shared	12.2988	16.2979	Yes	Yes	Yes	No	8	5
73	5x39	5x43	Shared	11.4289	29.8187	Yes	Yes	No	No	6	5
74	4x60	5x39	Shared	10.039	10.2153	No	No	Yes	Yes	5	6
75	E2.Y174	E2.Y185	Shared	31.1519	10.0153	Yes	Yes	No	Yes	5	1
76	5x47	6x52	Shared	12.7737	20.2826	Yes	Yes	Yes	Yes	8	7
77	7x42	Lig	Shared	52.5047	44.7856	Yes	Yes	Yes	Yes	6	0
78	3x36	Lig	beta2_on	0.869913	36.8954	No	No	Yes	Yes	6	0
79	2x53	3x36	beta2_on	0	14.9039	Yes	No	No	No	7	6
80	1x50	7x50	beta2_on	6.0344	36.2984	No	No	No	No	9	9
81	1x53	7x50	beta2_on	0	35.4138	No	No	No	No	9	9
82	1x53	7x54	beta2_on	0	31.8207	No	No	No	No	9	7
83	7x54	8x50	beta2_on	0	23.9114	No	No	Yes	Yes	7	9
84	8x50	I1x50	beta2_on	1.44986	14.567	Yes	Yes	No	No	9	8
85	1x60	I1x50	beta2_on	0	13.5564	Yes	Yes	No	No	6	8
86	3x49	I2x53	beta2_on	0	16.5608	Yes	No	No	Yes	8	7
87	I2x53	I2x57	beta2_on	0	11.8859	No	Yes	No	No	7	7
88	6x48	6x51	beta2_on	8.70413	33.861	Yes	Yes	Yes	Yes	8	6
89	6x48	7x45	beta2_on	0	92.9917	Yes	Yes	No	Yes	8	9
90	7x45	7x49	beta2_on	0	90.8117	No	Yes	No	Yes	9	9
91	3x43	7x49	beta2_on	0	89.2233	No	No	No	Yes	8	9
92	3x43	7x53	beta2_on	0	100	No	No	Yes	Yes	8	9
93	3x50	7x53	beta2_on	0	48.669	No	No	Yes	Yes	9	9
94	3x46	3x50	beta2_on	0	10.7794	No	No	No	No	9	9
95	3x36	6x48	beta2_on	0.69993	24.3112	No	No	Yes	Yes	6	8
96	6x52	Lig	beta2_on	8.24418	35.2906	Yes	Yes	Yes	Yes	7	0
97	6x48	6x52	beta2_on	6.42936	38.2319	Yes	Yes	Yes	Yes	8	7
98	2x46	3x42	beta2_on	0	11.497	No	Yes	No	No	9	8
99	2x46	2x50	beta2_on	0	16.3362	No	Yes	No	Yes	9	9
100	3x28	Lig	beta2_on	0	21.4055	Yes	Yes	Yes	Yes	5	0
101	3x28	E1x50	beta2_on	0.144985	10.8178	Yes	Yes	Yes	Yes	5	7
102	5x39	E2.Y174	beta2_on	4.59454	20.6222	Yes	Yes	Yes	Yes	6	5
103	3x26	E2.Y174	beta2_on	0	11.475	No	No	Yes	Yes	5	5
104	3x40	6x48	beta2_on	0	11.4066	No	No	Yes	Yes	7	8
105	3x50	5x58	beta2_on	0	48.8498	No	No	Yes	Yes	9	9
106	6x40	7x53	beta2_on	9.41406	44.2323	No	No	Yes	Yes	8	9
107	5x58	6x40	beta2_on	0	43.0191	Yes	Yes	No	No	9	8
108	5x57	5x58	beta2_on	0	45.6702	No	No	Yes	Yes	6	9
109	3x51	5x57	beta2_on	2.74973	43.0273	Yes	Yes	No	No	8	6
110	3x55	3x56	beta2_on	0	16.2979	No	No	No	No	7	6
111	3x56	I2x52	beta2_on	0	10.8862	No	No	No	No	6	5
112	2x64	7x39	beta2_on	1.27487	22.4626	No	No	No	Yes	5	5
113	2x64	7x35	beta2_on	0	20.9646	No	No	No	No	5	3
114	7x31	7x35	beta2_on	1.46485	19.3707	No	No	No	No	2	3
115	7x31	E2x51	beta2_on	2.73473	17.7631	No	No	Yes	No	2	3
116	5x47	6x49	beta2_on	4.34457	18.0534	Yes	Yes	No	Yes	8	6
117	5x58	6x37	beta2_on	1.40986	42.4577	Yes	Yes	No	Yes	9	8
118	5x62	6x37	beta2_on	0	15.7255	No	Yes	No	Yes	6	8
119	6x36	6x37	beta2_on	0	21.6794	No	No	No	Yes	8	8
120	6x32	6x36	beta2_on	0	18.9872	No	No	No	No	7	8
121	6x29	6x32	beta2_on	0	10.878	No	No	No	No	6	7
122	6x49	6x50	beta2_on	0	14.4164	No	Yes	No	No	6	9
123	6x50	7x37	beta2_on	1.67483	13.4935	No	No	Yes	Yes	9	5
124	2x50	7x49	beta2_on	0	16.3937	No	Yes	No	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	Shared	18.5471	17.15	1	1	1	0
3x33	Lig	Shared	10.9743	8.485	0	0	1	0
3x36	Lig	Shared	6.18286	6.925	1	0	1	0
E2x52	Lig	Shared	8.52143	10.845	0	0	1	0
5x43	Lig	Shared	6.21143	4.915	0	0	1	0
5x461	Lig	Shared	3.89714	4.52	0	0	1	0
6x48	Lig	beta2_off	3.73429	0	1	1	1	0
6x51	Lig	Shared	8.56429	7.655	1	1	1	0
6x52	Lig	Shared	12.1057	5.66	1	1	1	0
6x55	Lig	Shared	8.56571	5.945	0	1	1	0
7x38	Lig	Shared	14.6671	13.22	1	1	1	0
7x42	Lig	Shared	5.62	3.455	1	1	1	0
2x53	2x56	beta2_off	6.52286	0	1	0	2	2
2x53	7x42	beta2_off	3.93286	0	1	0	2	1
2x56	3x32	Shared	6.67429	8.03	1	1	2	1
2x56	7x42	Shared	4.33	4.42	1	1	2	1
2x57	7x42	Shared	3.78857	5.68	0	1	2	1
2x59	3x24	beta2_off	17.18	0	2	1	2	2
2x59	3x28	Shared	5.72714	6.015	2	1	2	1
2x63	E1x50	beta2_off	7.25429	0	0	0	1	2
3x24	E1x50	beta2_off	4.55143	0	2	0	2	2
3x28	E1x50	Shared	11.1129	11.715	2	1	1	2
3x24	3x28	beta2_off	5.62429	0	2	0	2	1
3x29	E2x52	beta2_off	5.56	0	0	0	2	1
3x32	7x42	Shared	9.36	9.77	1	1	1	1
3x33	4x57	Shared	5.53714	3.23	0	0	1	2
3x36	6x48	Shared	7.35571	8.585	1	0	1	1
3x37	5x461	Shared	7.76429	9.59	0	0	2	1
3x40	6x44	Shared	6.28	6.905	0	0	2	2
E2.Y174	E2x52	beta2_off	3.97857	0	8	0	2	1
5x39	E2.Y174	Shared	6.52571	5.46	0	0	2	2
E2.T195	E2x52	Shared	7.78	5.185	0	0	2	1
5x39	E2.T195	Shared	5.52857	4.995	0	0	2	2
5x39	5x43	Shared	13.2629	14.625	0	0	2	1
5x44	6x52	Shared	3.96	6.605	0	0	2	1
5x47	5x48	Shared	8.25143	6.705	0	1	2	2
5x47	6x52	Shared	31.8443	19.825	0	1	2	1
6x44	6x48	beta2_off	12.0271	0	0	0	2	1
6x44	7x45	beta2_off	6.55857	0	0	0	2	2
6x48	6x51	Shared	4.43714	3.51	1	1	1	1
6x48	6x52	Shared	5.15571	4.51	1	1	1	1
6x48	7x41	Shared	12.67	11.965	1	1	1	2
6x51	6x52	Shared	6.12429	6.97	1	1	1	1
6x51	7x34	Shared	10.9043	4.125	1	1	1	2
6x51	7x38	Shared	12.4257	15.105	1	1	1	1
6x55	7x34	Shared	5.64714	6.975	0	1	1	2
7x38	7x42	Shared	12.7943	9.305	1	1	1	1
7x39	7x42	Shared	14.4671	8.2	1	1	2	1
2x60	3x28	Shared	2.61143	2.11	0	0	2	1
6x51	7x37	beta2_off	2.09143	0	1	1	1	2
2x53	3x36	beta2_on	0	3.8	1	0	2	1
2x57	7x39	beta2_on	0	4.29	0	1	2	2
3x28	Lig	beta2_on	0	4.255	2	1	1	0
3x40	6x48	beta2_on	0	5.285	0	0	2	1
5x47	6x44	beta2_on	0	6.965	0	1	2	2
5x48	6x52	beta2_on	0	3.61	0	1	2	1
6x48	7x45	beta2_on	0	7.345	1	1	1	2
6x51	6x55	beta2_on	0	6.04	1	1	1	1
2x59	E1x50	beta2_on	0	3.51	2	1	2	2
3x28	3x29	beta2_on	0	3.035	2	1	1	2
2x63	Lig	beta2_on	0	2.95	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta2_off	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
	beta2_on	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2

Network Difference
Value	beta2_off	beta2_on
I_min	3.72571	3.07
Number of Linked Nodes	273	277
Number of Specific Nodes	12 (4.40%)	16 (5.78%)
Number of Shared Nodes	261 (95.60%)	261 (94.22%)
Number of Links	302	305
Number of Specific Links	116 (38.41%)	119 (39.02%)
Number of Shared Links	186 (61.59%)	186 (60.98%)
Number of Hubs	33	35
Number of Specific Hubs	13 (39.39%)	15 (42.86%)
Number of Shared Hubs	20 (60.61%)	20 (57.14%)
Average % Shared Neighbours (Jaccard)	47.80
Average % Shared Neighbours (Otsuka)	56.34
Average % Shared Neighbours (Overlap Coefficient)	64.72
Average % Shared Cliques (k3-6)	55.00
Graphlets Similarity	0.659533

Paths Difference
Value	beta2_off	beta2_on
Number Of Nodes in MetaPath	80	68
Specific Nodes in MetaPath	34 (42.50%)	22 (32.35%)
Shared Nodes in MetaPath	261 (95.60%)	261 (95.60%)
Number Of Links MetaPath	77	71
Specific Links in MetaPath	53 (68.83%)	47 (66.20%)
Shared Links in MetaPath	186 (61.59%)	186 (61.59%)
Number of Shortest Paths	42216	72132
Length Of Smallest Path	3	3
Average Path Length	15.0443	13.8795
Length of Longest Path	35	29
Minimum Path Strength	0.729286	0.77
Average Path Strength	6.41064	5.36723
Maximum Path Strength	26.2843	15.185
Minimum Path Correlation	0.704286	0.7
Average Path Correlation	0.923459	0.931011
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.33333	4.16667
Average % Of Corr. Nodes	44.5059	48.3415
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	36.996	47.1163
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta2_off_on.zip<

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