psnGPCR

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Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off Int. Strength	beta2_on Int. Strength	beta2_off Hub1?	beta2_on Hub1?	beta2_off Hub2?	beta2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x64	beta2_off	100	0	Yes	Yes	No	No	6	5
2	1x49	7x50	beta2_off	100	0	No	No	No	No	8	9
3	1x52	8x58	beta2_off	100	0	No	No	No	No	6	6
4	1x53	7x53	beta2_off	100	0	No	No	Yes	Yes	9	9
5	1x57	2x40	beta2_off	100	0	No	No	No	Yes	7	9
6	2x38	I2x55	beta2_off	100	0	No	No	No	No	6	4
7	2x39	3x50	beta2_off	100	0	No	No	No	Yes	8	9
8	2x41	4x43	beta2_off	100	0	No	No	No	No	4	3
9	2x42	3x46	beta2_off	100	0	Yes	Yes	No	No	8	9
10	2x43	7x53	beta2_off	100	0	No	No	Yes	Yes	8	9
11	2x51	2x55	beta2_off	100	0	No	No	No	No	7	5
12	2x53	2x56	beta2_off	100	0	Yes	No	No	No	7	7
13	2x53	7x42	beta2_off	100	0	Yes	No	Yes	Yes	7	6
14	2x59	3x24	beta2_off	100	0	No	No	Yes	No	5	5
15	2x66	E1x51	beta2_off	100	0	No	No	No	No	4	2
16	3x24	E1x50	beta2_off	100	0	Yes	No	Yes	Yes	5	7
17	3x24	3x28	beta2_off	100	0	Yes	No	Yes	Yes	5	5
18	3x26	4x64	beta2_off	100	0	No	No	No	No	5	4
19	3x26	E2.R175	beta2_off	100	0	No	No	Yes	No	5	2
20	3x27	3x31	beta2_off	100	0	Yes	No	No	No	5	4
21	3x29	E2x52	beta2_off	100	0	No	No	Yes	No	4	4
22	3x39	6x44	beta2_off	100	0	No	No	Yes	Yes	9	9
23	3x49	3x50	beta2_off	100	0	Yes	No	No	Yes	8	9
24	3x49	I2x55	beta2_off	100	0	Yes	No	No	No	8	4
25	3x49	I2x57	beta2_off	100	0	Yes	No	No	No	8	7
26	3x50	3x53	beta2_off	100	0	No	Yes	No	No	9	8
27	3x56	I2x51	beta2_off	100	0	No	No	No	No	6	6
28	3x56	I2x56	beta2_off	100	0	No	No	No	No	6	4
29	I2x52	I2x53	beta2_off	100	0	No	No	No	Yes	5	7
30	5x68	I2x52	beta2_off	100	0	No	No	No	No	7	5
31	6x30	I2x53	beta2_off	100	0	No	No	No	Yes	7	7
32	6x31	I2x53	beta2_off	100	0	Yes	No	No	Yes	5	7
33	I2x55	I2x57	beta2_off	100	0	No	No	No	No	4	7
34	4x41	I2x57	beta2_off	100	0	No	No	No	No	5	7
35	E2.R175	E2.Y174	beta2_off	100	0	Yes	No	Yes	Yes	2	5
36	E2.Y174	E2x52	beta2_off	100	0	Yes	Yes	Yes	No	5	4
37	E2.R175	E2.Y185	beta2_off	100	0	Yes	No	No	No	2	1
38	E2.A181	E2.H178	beta2_off	100	0	No	No	Yes	Yes	4	2
39	E2.F194	E2.H178	beta2_off	100	0	Yes	No	Yes	Yes	1	2
40	E2.A181	E2.Y185	beta2_off	100	0	No	No	No	No	4	1
41	E2.C184	E2.F194	beta2_off	100	0	No	No	Yes	No	1	1
42	E2.E187	E2.T189	beta2_off	100	0	No	No	No	No	4	4
43	7x31	E2x51	beta2_off	100	0	No	No	No	No	2	3
44	5x51	6x45	beta2_off	100	0	No	No	No	No	7	7
45	5x58	5x61	beta2_off	100	0	Yes	Yes	No	No	9	8
46	5x58	5x62	beta2_off	100	0	Yes	Yes	No	Yes	9	6
47	5x58	6x34	beta2_off	100	0	Yes	Yes	No	No	9	7
48	5x60	5x63	beta2_off	100	0	Yes	Yes	No	No	5	3
49	5x62	6x26	beta2_off	100	0	No	Yes	No	No	6	4
50	5x64	5x68	beta2_off	100	0	Yes	Yes	No	No	5	7
51	5x65	6x31	beta2_off	100	0	No	No	Yes	No	8	5
52	5x66	6x25	beta2_off	100	0	No	No	No	No	6	2
53	5x69	6x31	beta2_off	100	0	No	No	Yes	No	5	5
54	6x25	6x26	beta2_off	100	0	No	No	No	No	2	4
55	6x26	6x35	beta2_off	100	0	No	No	No	No	4	7
56	6x28	6x30	beta2_off	100	0	No	No	No	No	5	7
57	6x28	6x31	beta2_off	100	0	No	No	Yes	No	5	5
58	6x29	6x30	beta2_off	100	0	No	No	No	No	6	7
59	6x35	7x55	beta2_off	100	0	No	No	Yes	No	7	7
60	6x36	7x55	beta2_off	100	0	No	No	Yes	No	8	7
61	6x39	7x52	beta2_off	100	0	No	No	No	No	7	8
62	6x40	7x49	beta2_off	100	0	No	Yes	No	No	8	9
63	6x40	7x52	beta2_off	100	0	No	Yes	No	No	8	8
64	6x44	6x48	beta2_off	100	0	Yes	Yes	Yes	Yes	9	8
65	6x44	7x45	beta2_off	100	0	Yes	Yes	No	No	9	9
66	6x48	6x51	beta2_off	100	0	Yes	Yes	Yes	Yes	8	6
67	6x48	Lig	beta2_off	100	0	Yes	Yes	Yes	Yes	8	0
68	7x49	7x53	beta2_off	100	0	No	No	Yes	Yes	9	9
69	7x53	8x50	beta2_off	100	0	Yes	Yes	Yes	Yes	9	9
70	8x48	8x51	beta2_off	100	0	No	No	No	No	5	9
71	8x58	CT.L342	beta2_off	100	0	No	No	No	No	6	8
72	6x61	E3.N301	beta2_off	100	0	No	No	No	No	2	2
73	8x47	8x49	beta2_off	42.8571	0	No	No	No	No	8	7
74	1x53	7x50	beta2_off	28.5714	0	No	No	No	No	9	9
75	I2x51	I2x54	beta2_off	42.8571	0	No	No	No	No	6	4
76	1x28	1x30	beta2_off	57.1429	0	No	No	No	No	5	2
77	5x58	6x38	beta2_off	28.5714	0	Yes	Yes	No	No	9	6
78	E1x49	E1x51	beta2_off	42.8571	0	No	No	No	No	5	2
79	1x60	I1x50	beta2_off	28.5714	0	Yes	Yes	No	Yes	6	8
80	6x43	7x45	beta2_off	28.5714	0	No	No	No	No	6	9
81	7x33	E3.I303	beta2_off	28.5714	0	No	No	Yes	No	4	3
82	3x45	4x45	beta2_off	0	0	No	No	No	No	7	6
83	E2.C190	E2.E187	beta2_off	14.2857	0	No	No	No	No	3	4
84	1x43	2x57	beta2_off	14.2857	0	No	No	No	No	6	7
85	E2.A176	E2.H178	beta2_off	0	0	No	No	Yes	Yes	1	2
86	3x47	5x57	beta2_off	0	0	No	No	No	No	8	6
87	1x46	7x47	beta2_off	14.2857	0	No	No	No	No	8	7
88	2x62	E1x52	beta2_off	0	0	No	No	Yes	Yes	4	5
89	E3.I303	E3.L302	beta2_off	28.5714	0	Yes	No	No	No	3	1
90	3x52	I2x56	beta2_off	28.5714	0	No	No	No	No	5	4
91	3x23	3x27	beta2_off	42.8571	0	No	No	Yes	No	1	5
92	1x32	2x65	beta2_off	14.2857	0	No	No	No	No	4	6
93	8x55	CT.L342	beta2_off	0	0	No	No	No	No	4	8
94	6x47	7x48	beta2_off	0	0	Yes	No	No	No	9	6
95	6x57	E3.L302	beta2_off	28.5714	0	No	No	No	No	4	1
96	3x21	E2.E188	beta2_off	14.2857	0	No	No	No	No	7	3
97	5x41	6x56	beta2_off	28.5714	0	No	No	No	No	5	6
98	1x27	1x31	beta2_off	14.2857	0	No	No	Yes	No	5	3
99	1x54	2x51	beta2_off	0	0	No	No	No	No	7	7
100	3x34	4x54	beta2_off	14.2857	0	No	No	No	No	5	4
101	1x33	1x37	beta2_off	0	0	No	No	No	No	5	5
102	I1x48	I1x49	beta2_off	14.2857	0	No	No	No	Yes	6	6
103	6x47	7x40	beta2_off	0	0	Yes	No	No	No	9	7
104	1x58	1x59	beta2_off	14.2857	0	No	No	No	No	4	5
105	E2.I182	E2.Q179	beta2_off	14.2857	0	No	No	No	No	1	3
106	1x35	2x65	beta2_off	0	0	No	No	No	No	5	6
107	3x45	4x49	beta2_off	0	0	No	No	No	No	7	7
108	5x54	5x55	beta2_off	0	0	No	No	No	No	8	5
109	1x31	2x67	beta2_off	14.2857	0	Yes	No	No	No	3	4
110	4x56	4x57	beta2_off	0	0	No	No	No	No	5	7
111	1x38	1x42	beta2_off	0	0	No	No	No	No	5	6
112	1x28	1x31	beta2_off	0	0	No	No	Yes	No	5	3
113	1x29	1x33	beta2_off	0	0	No	No	No	No	3	5
114	3x41	4x52	beta2_off	14.2857	0	No	No	No	No	5	4
115	6x59	6x60	beta2_off	0	0	Yes	No	No	No	5	4
116	7x36	7x40	beta2_off	0	0	No	No	No	No	5	7
117	E2.E187	E2.N183	beta2_off	0	0	No	No	No	No	4	3
118	6x46	6x47	beta2_off	0	0	No	No	Yes	No	5	9
119	5x59	5x63	beta2_off	0	0	No	No	No	No	3	3
120	6x32	7x55	beta2_off	0	0	No	No	Yes	No	7	7
121	1x31	1x35	Shared	100	100	Yes	No	No	No	3	5
122	1x39	2x61	Shared	100	25	Yes	Yes	No	No	6	6
123	1x39	7x39	Shared	100	100	Yes	Yes	No	Yes	6	5
124	1x43	2x58	Shared	100	100	No	No	No	No	6	8
125	1x46	2x54	Shared	100	100	No	No	No	No	8	7
126	1x46	7x46	Shared	100	100	No	No	No	No	8	9
127	1x47	2x55	Shared	100	0	No	No	No	No	6	5
128	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
129	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
130	1x52	8x54	Shared	100	100	No	No	Yes	Yes	6	7
131	1x55	8x57	Shared	100	25	No	No	No	No	5	6
132	1x57	2x44	Shared	100	100	No	No	No	No	7	6
133	1x57	8x50	Shared	100	100	No	No	Yes	Yes	7	9
134	1x60	8x53	Shared	100	100	Yes	Yes	No	No	6	7
135	1x60	8x56	Shared	100	100	Yes	Yes	No	No	6	4
136	1x60	8x57	Shared	100	25	Yes	Yes	No	No	6	6
137	8x49	I1x49	Shared	100	100	No	No	No	Yes	7	6
138	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	9	8
139	2x37	2x40	Shared	100	25	No	No	No	Yes	7	9
140	2x40	8x50	Shared	100	100	No	Yes	Yes	Yes	9	9
141	2x41	4x39	Shared	100	100	No	No	No	No	4	1
142	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
143	2x42	3x49	Shared	100	100	Yes	Yes	Yes	No	8	8
144	2x42	4x46	Shared	100	100	Yes	Yes	No	Yes	8	8
145	2x45	3x42	Shared	100	100	No	No	No	No	9	8
146	2x45	4x46	Shared	100	100	No	No	No	Yes	9	8
147	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
148	2x46	3x43	Shared	100	100	No	Yes	No	No	9	8
149	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
150	2x53	3x35	Shared	100	100	Yes	No	No	No	7	7
151	2x53	7x46	Shared	100	100	Yes	No	No	No	7	9
152	2x56	3x32	Shared	100	100	No	No	No	No	7	7
153	2x56	7x42	Shared	100	100	No	No	Yes	Yes	7	6
154	2x57	7x42	Shared	100	100	No	No	Yes	Yes	7	6
155	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	5	5
156	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
157	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	7
158	2x64	7x39	Shared	100	50	No	No	No	Yes	5	5
159	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	7	5
160	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
161	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	7
162	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
163	E1x51	E1x52	Shared	100	50	No	No	Yes	Yes	2	5
164	3x24	E1x52	Shared	100	100	Yes	No	Yes	Yes	5	5
165	3x22	E2.E188	Shared	100	100	No	Yes	No	No	2	3
166	3x24	3x27	Shared	100	100	Yes	No	Yes	No	5	5
167	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
168	3x26	E2.Y174	Shared	100	100	No	No	Yes	Yes	5	5
169	3x27	4x58	Shared	100	100	Yes	No	No	No	5	4
170	3x30	4x58	Shared	100	100	No	No	No	No	6	4
171	3x30	4x61	Shared	100	100	No	No	No	No	6	5
172	3x30	4x62	Shared	100	100	No	No	No	No	6	4
173	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	6
174	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
175	3x33	4x57	Shared	100	100	No	No	No	No	5	7
176	3x33	Lig	Shared	100	100	No	No	Yes	Yes	5	0
177	3x34	4x50	Shared	100	100	No	No	Yes	Yes	5	9
178	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
179	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
180	3x37	4x53	Shared	100	100	No	No	No	No	6	8
181	3x37	5x461	Shared	100	100	No	No	No	No	6	5
182	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
183	3x40	5x50	Shared	100	100	No	No	Yes	Yes	7	8
184	3x40	6x44	Shared	100	100	No	No	Yes	Yes	7	9
185	3x41	5x50	Shared	100	100	No	No	Yes	Yes	5	8
186	3x43	6x44	Shared	100	100	No	No	Yes	Yes	8	9
187	3x44	5x50	Shared	100	100	No	No	Yes	Yes	7	8
188	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
189	3x51	5x60	Shared	100	100	No	Yes	Yes	Yes	8	5
190	3x54	5x64	Shared	100	25	No	No	Yes	Yes	9	5
191	4x38	4x41	Shared	100	100	No	No	No	No	8	5
192	4x60	E2.W173	Shared	100	25	No	No	No	No	5	4
193	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	6
194	4x61	E2.Y174	Shared	100	100	No	No	Yes	Yes	5	5
195	4x63	E2.W173	Shared	100	100	No	No	No	No	4	4
196	4x64	E2.R175	Shared	100	100	No	No	Yes	No	4	2
197	E2.Y174	E2.Y185	Shared	100	100	Yes	Yes	No	No	5	1
198	5x39	E2.Y174	Shared	100	100	Yes	Yes	Yes	Yes	6	5
199	E2.E180	E2.H178	Shared	100	100	No	No	Yes	Yes	3	2
200	E2.E180	E2.F194	Shared	100	100	No	No	Yes	No	3	1
201	E2.A181	E2.F194	Shared	100	100	No	No	Yes	No	4	1
202	E2.C184	E2.C190	Shared	100	100	No	No	No	No	1	3
203	E2.C190	E2x51	Shared	100	100	No	No	No	No	3	3
204	E2.F194	E2x51	Shared	100	100	Yes	No	No	No	1	3
205	E2.T195	E2x52	Shared	100	100	No	No	Yes	No	3	4
206	E2x52	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
207	5x39	E2.T195	Shared	100	100	Yes	Yes	No	No	6	3
208	5x37	6x59	Shared	100	100	No	No	Yes	No	2	5
209	5x39	5x43	Shared	100	100	Yes	Yes	No	No	6	5
210	5x41	6x59	Shared	100	50	No	No	Yes	No	5	5
211	5x43	Lig	Shared	100	100	No	No	Yes	Yes	5	0
212	5x44	6x52	Shared	100	100	No	No	Yes	Yes	5	7
213	5x461	Lig	Shared	100	100	No	No	Yes	Yes	5	0
214	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	5
215	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	7
216	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
217	5x48	6x56	Shared	100	25	No	No	No	No	5	6
218	5x54	6x41	Shared	100	100	No	No	No	No	8	8
219	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
220	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
221	5x60	5x64	Shared	100	50	Yes	Yes	Yes	Yes	5	5
222	5x64	5x67	Shared	100	100	Yes	Yes	No	No	5	4
223	6x39	7x55	Shared	100	50	No	No	Yes	No	7	7
224	6x40	7x53	Shared	100	100	No	Yes	Yes	Yes	8	9
225	6x47	7x45	Shared	100	100	Yes	No	No	No	9	9
226	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
227	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
228	6x49	6x53	Shared	100	100	No	Yes	No	No	6	6
229	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	7
230	6x51	7x34	Shared	100	100	Yes	Yes	No	No	6	5
231	6x51	7x38	Shared	100	100	Yes	Yes	No	No	6	5
232	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
233	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
234	6x54	7x37	Shared	100	50	No	No	No	Yes	5	5
235	6x55	7x34	Shared	100	100	No	No	No	No	5	5
236	6x55	Lig	Shared	100	100	No	No	Yes	Yes	5	0
237	6x58	E3.I303	Shared	100	50	No	No	Yes	No	3	3
238	7x30	7x32	Shared	100	25	No	No	No	No	4	2
239	7x38	7x42	Shared	100	100	No	No	Yes	Yes	5	6
240	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
241	7x39	7x42	Shared	100	100	No	Yes	Yes	Yes	5	6
242	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
243	7x43	7x48	Shared	100	50	No	No	No	No	5	6
244	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
245	8x50	8x54	Shared	100	100	Yes	Yes	Yes	Yes	9	7
246	E2.N183	E2.Q179	Shared	100	100	No	No	No	No	3	3
247	6x54	E3.I303	Shared	100	25	No	No	Yes	No	5	3
248	2x41	I1x51	Shared	42.8571	100	No	No	No	No	4	8
249	3x34	4x57	Shared	28.5714	100	No	No	No	No	5	7
250	2x60	3x28	Shared	57.1429	0	No	No	Yes	Yes	7	5
251	6x61	E3.L302	Shared	14.2857	100	No	No	No	No	2	1
252	1x50	2x47	Shared	57.1429	50	No	Yes	No	No	9	9
253	3x56	I2x50	Shared	28.5714	0	No	No	No	No	6	8
254	8x47	8x48	Shared	28.5714	100	No	No	No	No	8	5
255	5x49	5x50	Shared	28.5714	100	No	No	Yes	Yes	5	8
256	5x36	5x39	Shared	14.2857	100	No	No	Yes	Yes	4	6
257	3x47	5x58	Shared	57.1429	100	No	No	Yes	Yes	8	9
258	2x52	3x35	Shared	14.2857	100	No	No	No	No	7	7
259	1x51	2x51	Shared	42.8571	25	No	No	No	No	3	7
260	2x38	4x42	Shared	28.5714	0	No	No	No	No	6	7
261	1x42	7x43	Shared	57.1429	100	No	No	No	No	6	5
262	7x31	7x32	Shared	14.2857	50	No	No	No	No	2	2
263	4x40	4x43	Shared	57.1429	50	No	No	No	No	4	3
264	3x44	5x53	Shared	14.2857	100	No	No	No	No	7	6
265	1x54	2x47	Shared	14.2857	100	No	No	No	No	7	9
266	1x36	2x65	Shared	0	25	No	No	No	No	5	6
267	6x58	E3.D300	Shared	28.5714	100	No	No	No	No	3	1
268	5x56	5x60	Shared	28.5714	25	No	No	Yes	Yes	4	5
269	3x51	3x52	Shared	28.5714	100	No	Yes	No	No	8	5
270	1x59	1x60	Shared	14.2857	100	No	No	Yes	Yes	5	6
271	3x21	E1x50	Shared	0	100	No	No	Yes	Yes	7	7
272	7x54	8x54	Shared	0	100	No	No	Yes	Yes	7	7
273	5x47	6x49	Shared	14.2857	100	Yes	Yes	No	Yes	8	6
274	5x45	5x48	Shared	28.5714	50	No	No	No	No	4	5
275	2x64	7x35	Shared	0	25	No	No	No	No	5	3
276	3x48	3x52	Shared	0	50	No	No	No	No	6	5
277	2x49	4x50	Shared	0	100	No	No	Yes	Yes	8	9
278	6x50	7x37	Shared	28.5714	100	No	No	No	Yes	9	5
279	8x52	I1x49	Shared	28.5714	0	No	No	No	Yes	4	6
280	3x54	5x61	Shared	14.2857	50	No	No	No	No	9	8
281	1x48	1x49	Shared	0	25	No	Yes	No	No	4	8
282	1x56	8x54	Shared	0	25	No	No	Yes	Yes	8	7
283	6x51	7x37	Shared	0	100	Yes	Yes	No	Yes	6	5
284	4x55	4x59	Shared	28.5714	25	No	No	No	No	4	5
285	4x59	4x60	Shared	14.2857	100	No	No	No	No	5	5
286	1x54	2x48	Shared	0	25	No	No	No	No	7	6
287	1x37	1x41	Shared	0	25	No	No	No	No	5	5
288	6x42	6x45	Shared	0	0	No	No	No	No	5	7
289	5x36	5x38	Shared	0	100	No	No	No	No	4	4
290	5x40	6x59	Shared	0	0	No	No	Yes	No	5	5
291	4x47	4x51	Shared	14.2857	25	No	No	No	No	3	4
292	2x551	3x31	Shared	0	0	No	No	No	No	4	4
293	4x38	4x40	Shared	0	100	No	No	No	No	8	4
294	1x35	1x39	Shared	0	100	No	No	Yes	Yes	5	6
295	4x48	4x52	Shared	0	25	No	No	No	No	4	4
296	4x44	4x48	Shared	0	0	No	No	No	No	4	4
297	1x34	1x37	Shared	0	0	No	No	No	No	5	5
298	1x44	1x48	Shared	14.2857	100	No	No	No	Yes	5	4
299	4x51	4x55	Shared	0	0	No	No	No	No	4	4
300	1x32	1x33	Shared	0	0	No	No	No	No	4	5
301	4x56	5x46	Shared	0	50	No	No	No	No	5	4
302	7x48	7x51	Shared	0	0	No	No	No	No	6	6
303	1x29	1x31	beta2_on	0	100	No	No	Yes	No	3	3
304	1x42	7x39	beta2_on	0	100	No	No	No	Yes	6	5
305	1x53	2x47	beta2_on	0	100	No	No	No	No	9	9
306	1x57	I1x50	beta2_on	0	100	No	No	No	Yes	7	8
307	2x40	I1x50	beta2_on	0	100	No	Yes	No	Yes	9	8
308	2x39	3x49	beta2_on	0	100	No	No	Yes	No	8	8
309	2x39	I2x53	beta2_on	0	100	No	No	No	Yes	8	7
310	2x40	2x43	beta2_on	0	100	No	Yes	No	No	9	8
311	2x46	2x50	beta2_on	0	100	No	Yes	No	Yes	9	9
312	2x46	3x42	beta2_on	0	100	No	Yes	No	No	9	8
313	2x46	7x49	beta2_on	0	100	No	Yes	No	No	9	9
314	2x46	7x53	beta2_on	0	100	No	Yes	Yes	Yes	9	9
315	2x50	7x49	beta2_on	0	100	No	Yes	No	No	9	9
316	3x28	Lig	beta2_on	0	100	Yes	Yes	Yes	Yes	5	0
317	3x34	4x58	beta2_on	0	100	No	No	No	No	5	4
318	3x37	4x56	beta2_on	0	100	No	No	No	No	6	5
319	3x38	4x53	beta2_on	0	100	No	No	No	No	7	8
320	3x40	6x48	beta2_on	0	100	No	No	Yes	Yes	7	8
321	3x43	7x53	beta2_on	0	100	No	No	Yes	Yes	8	9
322	3x46	3x50	beta2_on	0	100	No	No	No	Yes	9	9
323	3x46	7x53	beta2_on	0	100	No	No	Yes	Yes	9	9
324	3x49	I2x53	beta2_on	0	100	Yes	No	No	Yes	8	7
325	3x50	5x58	beta2_on	0	100	No	Yes	Yes	Yes	9	9
326	3x50	6x40	beta2_on	0	100	No	Yes	No	Yes	9	8
327	3x50	7x53	beta2_on	0	100	No	Yes	Yes	Yes	9	9
328	3x51	5x57	beta2_on	0	100	No	Yes	No	No	8	6
329	3x53	I2x53	beta2_on	0	100	No	No	No	Yes	8	7
330	3x55	5x60	beta2_on	0	100	No	No	Yes	Yes	7	5
331	I2x52	I2x56	beta2_on	0	100	No	No	No	No	5	4
332	I2x53	I2x54	beta2_on	0	100	No	Yes	No	No	7	4
333	I2x53	I2x57	beta2_on	0	100	No	Yes	No	No	7	7
334	4x61	5x39	beta2_on	0	100	No	No	Yes	Yes	5	6
335	E2.E188	E2.T189	beta2_on	0	100	No	No	No	No	3	4
336	7x34	E2x52	beta2_on	0	100	No	No	Yes	No	5	4
337	5x40	E2.T195	beta2_on	0	100	No	No	No	No	5	3
338	5x47	6x44	beta2_on	0	100	Yes	Yes	Yes	Yes	8	9
339	5x47	6x48	beta2_on	0	100	Yes	Yes	Yes	Yes	8	8
340	5x54	6x44	beta2_on	0	100	No	No	Yes	Yes	8	9
341	5x57	5x58	beta2_on	0	100	No	No	Yes	Yes	6	9
342	5x58	6x40	beta2_on	0	100	Yes	Yes	No	Yes	9	8
343	5x62	6x34	beta2_on	0	100	No	Yes	No	No	6	7
344	5x62	6x37	beta2_on	0	100	No	Yes	No	No	6	8
345	5x69	6x29	beta2_on	0	100	No	No	No	No	5	6
346	6x45	6x49	beta2_on	0	100	No	No	No	Yes	7	6
347	6x48	7x45	beta2_on	0	100	Yes	Yes	No	No	8	9
348	6x49	6x50	beta2_on	0	100	No	Yes	No	No	6	9
349	6x51	6x55	beta2_on	0	100	Yes	Yes	No	No	6	5
350	E3.D300	E3.N301	beta2_on	0	100	No	No	No	No	1	2
351	7x30	7x33	beta2_on	0	100	No	No	No	No	4	4
352	7x45	7x49	beta2_on	0	100	No	No	No	No	9	9
353	7x52	7x53	beta2_on	0	100	No	No	Yes	Yes	8	9
354	7x54	8x50	beta2_on	0	100	No	No	Yes	Yes	7	9
355	8x51	8x55	beta2_on	0	100	No	No	No	No	9	4
356	1x60	I1x49	beta2_on	0	100	Yes	Yes	No	Yes	6	6
357	I1x48	I1x51	beta2_on	0	100	No	No	No	No	6	8
358	3x22	3x26	beta2_on	0	100	No	Yes	No	No	2	5
359	3x26	E2.Y185	beta2_on	0	100	No	No	No	No	5	1
360	E2.H178	E2.I182	beta2_on	0	100	Yes	Yes	No	No	2	1
361	E2.E180	E2.Q179	beta2_on	0	100	No	No	No	No	3	3
362	E2.C184	E2.N183	beta2_on	0	100	No	No	No	No	1	3
363	5x66	6x30	beta2_on	0	100	No	No	No	No	6	7
364	I3.F240	I3.R239	beta2_on	0	100	No	No	No	No	0	0
365	6x51	7x40	beta2_on	0	100	Yes	Yes	No	No	6	7
366	1x29	1x32	beta2_on	0	100	No	No	No	No	3	4
367	5x62	5x66	beta2_on	0	100	No	Yes	No	No	6	6
368	E2.H178	E2.Q179	beta2_on	0	100	Yes	Yes	No	No	2	3
369	2x57	2x58	beta2_on	0	50	No	No	No	No	7	8
370	3x56	I2x52	beta2_on	0	25	No	No	No	No	6	5
371	6x43	7x52	beta2_on	0	50	No	No	No	No	6	8
372	4x39	4x43	beta2_on	0	25	No	No	No	No	1	3
373	I1x49	I1x50	beta2_on	0	50	No	Yes	No	Yes	6	8
374	3x28	3x29	beta2_on	0	25	Yes	Yes	No	No	5	4
375	5x36	E2.R175	beta2_on	0	25	No	No	Yes	No	4	2
376	2x52	3x31	beta2_on	0	50	No	No	No	No	7	4
377	6x57	E3.I303	beta2_on	0	50	No	No	Yes	No	4	3
378	6x27	6x30	beta2_on	0	25	No	No	No	No	3	7
379	7x33	7x37	beta2_on	0	0	No	No	No	Yes	4	5
380	2x42	4x45	beta2_on	0	25	Yes	Yes	No	No	8	6
381	1x53	7x54	beta2_on	0	50	No	No	No	No	9	7
382	5x72	5x73	beta2_on	0	25	No	No	No	Yes	0	0
383	5x73	6x29	beta2_on	0	25	No	Yes	No	No	0	6
384	E1x49	E2.T189	beta2_on	0	50	No	No	No	No	5	4
385	E2.A176	E2.Y185	beta2_on	0	25	No	No	No	No	1	1
386	3x52	3x56	beta2_on	0	25	No	No	No	No	5	6
387	6x31	6x35	beta2_on	0	50	Yes	No	No	No	5	7
388	2x50	3x39	beta2_on	0	25	No	Yes	No	No	9	9
389	E2.I182	E2.R175	beta2_on	0	25	No	No	Yes	No	1	2
390	1x48	1x52	beta2_on	0	0	No	Yes	No	No	4	6
391	2x41	4x46	beta2_on	0	25	No	No	No	Yes	4	8
392	6x28	6x29	beta2_on	0	25	No	No	No	No	5	6
393	2x42	4x42	beta2_on	0	25	Yes	Yes	No	No	8	7
394	6x60	6x61	beta2_on	0	25	No	No	No	No	4	2
395	5x72	5x76	beta2_on	0	25	No	No	No	Yes	0	0
396	5x76	I3.G238	beta2_on	0	25	No	Yes	No	No	0	0
397	7x47	7x50	beta2_on	0	25	No	No	No	No	7	9
398	5x69	6x30	beta2_on	0	25	No	No	No	No	5	7
399	7x32	7x36	beta2_on	0	25	No	No	No	No	2	5
400	5x63	5x64	beta2_on	0	25	No	No	Yes	Yes	3	5
401	E2.E187	E2.E188	beta2_on	0	25	No	No	No	No	4	3
402	I2x55	I2x56	beta2_on	0	25	No	No	No	No	4	4
403	7x55	8x51	beta2_on	0	50	Yes	No	No	No	7	9
404	4x54	4x57	beta2_on	0	25	No	No	No	No	4	7
405	5x67	5x71	beta2_on	0	25	No	No	No	No	4	0
406	6x57	6x61	beta2_on	0	25	No	No	No	No	4	2
407	5x68	5x71	beta2_on	0	25	No	No	No	No	7	0
408	3x41	4x49	beta2_on	0	0	No	No	No	No	5	7
409	5x55	6x41	beta2_on	0	0	No	No	No	No	5	8
410	1x38	1x39	beta2_on	0	25	No	No	Yes	Yes	5	6
411	3x22	3x23	beta2_on	0	25	No	Yes	No	No	2	1
412	2x65	2x66	beta2_on	0	25	No	No	No	No	6	4
413	5x73	I3.V242	beta2_on	0	25	No	Yes	No	No	0	0
414	5x76	I3.R239	beta2_on	0	25	No	Yes	No	No	0	0
415	5x75	5x76	beta2_on	0	25	No	No	No	Yes	0	0
416	5x62	6x33	beta2_on	0	25	No	Yes	No	No	6	8
417	1x50	2x51	beta2_on	0	25	No	Yes	No	No	9	7
418	6x31	6x34	beta2_on	0	25	Yes	No	No	No	5	7
419	1x30	1x31	beta2_on	0	25	No	No	Yes	No	2	3
420	1x48	8x58	beta2_on	0	0	No	Yes	No	No	4	6
421	2x66	E1x49	beta2_on	0	0	No	No	No	No	4	5
422	3x22	E2.A186	beta2_on	0	25	No	Yes	No	No	2	1
423	4x44	4x45	beta2_on	0	25	No	No	No	No	4	6
424	1x47	2x51	beta2_on	0	0	No	No	No	No	6	7
425	6x39	6x40	beta2_on	0	0	No	No	No	Yes	7	8
426	2x64	2x67	beta2_on	0	25	No	No	No	No	5	4
427	E2.H178	E2.T177	beta2_on	0	25	Yes	Yes	No	No	2	3
428	5x65	6x33	beta2_on	0	0	No	No	No	No	8	8
429	1x40	1x43	beta2_on	0	25	No	No	No	No	4	6
430	6x36	6x39	beta2_on	0	0	No	No	No	No	8	7
431	6x36	6x40	beta2_on	0	25	No	No	No	Yes	8	8
432	6x32	6x35	beta2_on	0	25	No	No	No	No	7	7
433	4x46	4x47	beta2_on	0	25	No	Yes	No	No	8	3
434	6x38	6x42	beta2_on	0	0	No	No	No	No	6	5
435	1x34	1x35	beta2_on	0	0	No	No	No	No	5	5
436	5x55	5x59	beta2_on	0	0	No	No	No	No	5	3
437	8x58	8x59	beta2_on	0	0	No	No	No	No	6	5
438	1x58	I1x51	beta2_on	0	0	No	No	No	No	4	8
439	6x45	6x46	beta2_on	0	0	No	No	No	No	7	5
440	5x71	5x74	beta2_on	0	0	No	No	No	No	0	0
441	5x70	5x73	beta2_on	0	0	No	No	No	Yes	0	0
442	I2x51	I2x52	beta2_on	0	0	No	No	No	No	6	5

Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	beta2_off Avg Int. Strength	beta2_on Avg Int. Strength	beta2_off Num Of Links	beta2_on Num Of Links	ConSurf
1	1x31	beta2_off	0	0	4	3	3
2	2x53	beta2_off	42.8571	25	4	2	7
3	3x24	beta2_off	100	0	5	2	5
4	3x27	beta2_off	42.8571	0	4	2	5
5	3x49	beta2_off	85.7143	25	4	3	8
6	E2.R175	beta2_off	71.4286	0	4	3	2
7	E2x52	beta2_off	71.4286	25	4	3	4
8	E2.F194	beta2_off	71.4286	0	5	3	1
9	6x31	beta2_off	57.1429	0	4	2	5
10	6x47	beta2_off	0	0	4	1	9
11	6x59	beta2_off	0	0	4	3	5
12	E3.I303	beta2_off	0	25	4	3	3
13	7x55	beta2_off	0	0	4	2	7
14	1x39	Shared	0	25	4	4	6
15	1x60	Shared	0	75	5	5	6
16	2x42	Shared	85.7143	50	4	5	8
17	E1x50	Shared	100	100	7	6	7
18	E1x52	Shared	85.7143	25	5	4	5
19	3x28	Shared	71.4286	25	4	5	5
20	4x50	Shared	14.2857	50	4	4	9
21	E2.Y174	Shared	100	75	6	4	5
22	E2.H178	Shared	0	0	4	4	2
23	5x39	Shared	100	100	5	6	6
24	5x47	Shared	14.2857	100	4	6	8
25	5x50	Shared	28.5714	25	4	4	8
26	5x58	Shared	100	100	7	6	9
27	5x60	Shared	0	0	4	4	5
28	5x64	Shared	85.7143	25	4	4	5
29	6x44	Shared	100	75	5	4	9
30	6x48	Shared	85.7143	100	6	6	8
31	6x51	Shared	85.7143	75	6	7	6
32	6x52	Shared	85.7143	100	5	5	7
33	7x42	Shared	100	100	7	6	6
34	7x53	Shared	100	75	5	6	9
35	8x50	Shared	100	100	6	6	9
36	8x54	Shared	0	25	4	4	7
37	Lig	Shared	100	100	12	12	0
38	1x48	beta2_on	0	0	2	4	4
39	1x50	beta2_on	0	0	3	4	9
40	I1x49	beta2_on	0	0	3	4	6
41	I1x50	beta2_on	0	25	2	4	8
42	2x40	beta2_on	42.8571	0	3	4	9
43	2x46	beta2_on	0	25	1	5	9
44	2x50	beta2_on	0	50	2	5	9
45	3x22	beta2_on	0	0	1	4	2
46	3x50	beta2_on	57.1429	25	3	4	9
47	3x51	beta2_on	0	75	3	4	8
48	I2x53	beta2_on	28.5714	25	3	5	7
49	4x46	beta2_on	0	0	2	4	8
50	5x62	beta2_on	0	25	2	4	6
51	5x73	beta2_on	0	0	0	4	0
52	5x76	beta2_on	0	0	0	4	0
53	6x40	beta2_on	0	0	3	5	8
54	6x49	beta2_on	0	50	2	4	6
55	7x37	beta2_on	0	0	3	4	5
56	7x39	beta2_on	42.8571	25	3	4	5

Orange: nodes, hubs and links specific of beta2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of beta2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	beta2_off Recurrence	beta2_on Recurrence	beta2_off Hub1?	beta2_on Hub1?	beta2_off Hub2?	beta2_on Hub2?	ConSurf1	ConSurf2
1	2x53	7x42	beta2_off	99.6802	0	Yes	No	Yes	Yes	7	6
2	1x50	7x50	beta2_off	90.8702	5.73786	No	Yes	No	No	9	9
3	1x53	7x50	beta2_off	88.0023	0	No	No	No	No	9	9
4	1x53	7x53	beta2_off	87.1924	0	No	No	Yes	Yes	9	9
5	7x53	8x50	beta2_off	37.2157	0	Yes	Yes	Yes	Yes	9	9
6	8x50	8x54	beta2_off	10.4297	0.888077	Yes	Yes	Yes	Yes	9	7
7	1x60	I1x50	beta2_off	10.1769	0	Yes	Yes	No	Yes	6	8
8	8x47	8x50	beta2_off	10.538	5.73786	No	No	Yes	Yes	8	9
9	3x49	I2x57	beta2_off	11.3323	0	Yes	No	No	No	8	7
10	4x41	I2x57	beta2_off	10.0583	0	No	No	No	No	5	7
11	6x48	Lig	beta2_off	30.7061	0	Yes	Yes	Yes	Yes	8	0
12	6x44	6x48	beta2_off	32.4289	0	Yes	Yes	Yes	Yes	9	8
13	E2.Y174	E2x52	beta2_off	59.8442	0	Yes	Yes	Yes	No	5	4
14	4x61	E2.Y174	beta2_off	32.0524	3.5901	No	No	Yes	Yes	5	5
15	3x30	4x61	beta2_off	30.8093	7.1739	No	No	No	No	6	5
16	3x30	4x58	beta2_off	28.4211	7.92971	No	No	No	No	6	4
17	3x27	4x58	beta2_off	27.1316	5.48592	Yes	No	No	No	5	4
18	3x24	3x27	beta2_off	21.9477	4.69862	Yes	No	Yes	No	5	5
19	3x40	6x44	beta2_off	12.854	8.08087	No	No	Yes	Yes	7	9
20	6x40	7x52	beta2_off	59.2975	0	No	Yes	No	No	8	8
21	6x39	7x52	beta2_off	58.2246	0	No	No	No	No	7	8
22	6x39	7x55	beta2_off	57.1104	5.90162	No	No	Yes	No	7	7
23	6x35	7x55	beta2_off	53.964	0	No	No	Yes	No	7	7
24	6x26	6x35	beta2_off	53.0355	0	No	No	No	No	4	7
25	5x62	6x26	beta2_off	49.5693	0	No	Yes	No	No	6	4
26	5x58	5x62	beta2_off	48.5944	0	Yes	Yes	No	Yes	9	6
27	5x58	5x61	beta2_off	37.6386	0	Yes	Yes	No	No	9	8
28	3x54	5x61	beta2_off	36.3697	2.58235	No	No	No	No	9	8
29	3x54	5x64	beta2_off	35.0905	5.15841	No	No	Yes	Yes	9	5
30	5x64	5x68	beta2_off	14.6645	0	Yes	Yes	No	No	5	7
31	5x68	I2x52	beta2_off	13.2202	0	No	No	No	No	7	5
32	I2x52	I2x53	beta2_off	11.7656	0	No	No	No	Yes	5	7
33	E2.Y174	E2.Y185	beta2_off	31.8822	4.45928	Yes	Yes	No	No	5	1
34	E2.A181	E2.Y185	beta2_off	31.1549	0	No	No	No	No	4	1
35	E2.A181	E2.F194	beta2_off	25.806	2.20445	No	No	Yes	No	4	1
36	E2.F194	E2x51	beta2_off	13.7205	4.3837	Yes	No	No	No	1	3
37	E2.C190	E2.E187	beta2_off	14.0249	0	No	No	No	No	3	4
38	5x47	5x48	beta2_off	11.5077	6.82119	Yes	Yes	No	No	8	5
39	6x44	7x45	beta2_off	15.5981	0	Yes	Yes	No	No	9	9
40	6x47	7x45	beta2_off	12.854	2.85318	Yes	No	No	No	9	9
41	1x35	2x65	beta2_off	11.7862	0	No	No	No	No	5	6
42	1x35	1x39	Shared	20.034	20.9674	No	No	Yes	Yes	5	6
43	1x39	7x39	Shared	22.3861	27.5619	Yes	Yes	No	Yes	6	5
44	7x39	7x42	Shared	26.5023	44.8951	No	Yes	Yes	Yes	5	6
45	2x53	7x46	Shared	99.0509	14.2596	Yes	No	No	No	7	9
46	2x50	7x46	Shared	96.7195	22.668	No	Yes	No	No	9	9
47	1x50	2x50	Shared	96.1108	100	No	Yes	No	Yes	9	9
48	1x50	2x47	Shared	10.538	82.8494	No	Yes	No	No	9	9
49	8x50	I1x50	Shared	11.6418	27.8957	Yes	Yes	No	Yes	9	8
50	7x42	Lig	Shared	100	53.8074	Yes	Yes	Yes	Yes	6	0
51	3x33	Lig	Shared	41.2544	18.3536	No	No	Yes	Yes	5	0
52	3x33	4x57	Shared	40.1042	16.6089	No	No	No	No	5	7
53	3x34	4x57	Shared	36.5915	16.6971	No	No	No	No	5	7
54	3x34	4x50	Shared	34.1982	27.1966	No	No	Yes	Yes	5	9
55	2x45	4x50	Shared	30.5308	31.9582	No	No	Yes	Yes	9	9
56	2x45	4x46	Shared	28.0342	50.4251	No	No	No	Yes	9	8
57	2x42	4x46	Shared	26.7705	31.0323	Yes	Yes	No	Yes	8	8
58	2x42	3x49	Shared	20.4622	13.4912	Yes	Yes	Yes	No	8	8
59	E2x52	Lig	Shared	62.0364	11.1293	Yes	No	Yes	Yes	4	0
60	3x40	5x50	Shared	11.4664	17.2262	No	No	Yes	Yes	7	8
61	6x40	7x53	Shared	60.0763	39.7493	No	Yes	Yes	Yes	8	9
62	5x60	5x64	Shared	19.1726	20.3943	Yes	Yes	Yes	Yes	5	5
63	3x51	5x60	Shared	13.4575	25.3133	No	Yes	Yes	Yes	8	5
64	3x51	3x52	Shared	10.538	20.4006	No	Yes	No	No	8	5
65	5x43	Lig	Shared	12.3124	64.5903	No	No	Yes	Yes	5	0
66	5x39	5x43	Shared	11.6212	63.1857	Yes	Yes	No	No	6	5
67	4x60	5x39	Shared	10.1408	15.28	No	No	Yes	Yes	5	6
68	6x52	Lig	Shared	18.9766	83.832	Yes	Yes	Yes	Yes	7	0
69	5x47	6x52	Shared	19.7091	56.2323	Yes	Yes	Yes	Yes	8	7
70	6x51	Lig	Shared	15.1906	15.6768	Yes	Yes	Yes	Yes	6	0
71	6x51	7x37	Shared	22.577	30.0183	Yes	Yes	No	Yes	6	5
72	6x54	7x37	Shared	18.564	22.0445	No	No	No	Yes	5	5
73	6x54	E3.I303	Shared	16.542	19.6448	No	No	Yes	No	5	3
74	1x31	1x35	beta2_on	7.22649	11.7717	Yes	No	No	No	3	5
75	3x36	Lig	beta2_on	1.33079	37.1355	No	No	Yes	Yes	6	0
76	3x36	6x48	beta2_on	0.278537	37.6394	No	No	Yes	Yes	6	8
77	6x48	7x45	beta2_on	0	75.8456	Yes	Yes	No	No	8	9
78	7x45	7x49	beta2_on	0	74.9008	No	No	No	No	9	9
79	2x50	7x49	beta2_on	0	68.8732	No	Yes	No	No	9	9
80	6x48	6x52	beta2_on	2.22314	45.103	Yes	Yes	Yes	Yes	8	7
81	1x53	2x47	beta2_on	0	75.3102	No	No	No	No	9	9
82	1x53	7x54	beta2_on	0	72.7719	No	No	No	No	9	7
83	7x54	8x54	beta2_on	1.53195	21.2446	No	No	Yes	Yes	7	7
84	1x52	8x54	beta2_on	6.01434	16.5459	No	No	Yes	Yes	6	7
85	7x54	8x50	beta2_on	0	48.9702	No	No	Yes	Yes	7	9
86	I1x49	I1x50	beta2_on	0	25.4456	No	Yes	No	Yes	6	8
87	1x60	I1x49	beta2_on	0	17.075	Yes	Yes	No	Yes	6	6
88	2x41	4x46	beta2_on	0	20.3439	No	No	No	Yes	4	8
89	2x45	3x42	beta2_on	1.4649	49.6441	No	No	No	No	9	8
90	2x46	3x42	beta2_on	0	51.2061	No	Yes	No	No	9	8
91	5x47	6x44	beta2_on	0	66.2909	Yes	Yes	Yes	Yes	8	9
92	3x43	6x44	beta2_on	2.92464	25.4015	No	No	Yes	Yes	8	9
93	2x46	3x43	beta2_on	1.4649	14.3604	No	Yes	No	No	9	8
94	3x43	7x53	beta2_on	0	11.249	No	No	Yes	Yes	8	9
95	2x53	3x35	beta2_on	3.05875	11.4316	Yes	No	No	No	7	7
96	3x28	Lig	beta2_on	0	29.7096	Yes	Yes	Yes	Yes	5	0
97	3x28	E1x50	beta2_on	0.149585	16.2247	Yes	Yes	Yes	Yes	5	7
98	5x39	E2.Y174	beta2_on	3.37855	28.3303	Yes	Yes	Yes	Yes	6	5
99	3x26	E2.Y174	beta2_on	2.6461	25.2189	No	No	Yes	Yes	5	5
100	3x22	3x26	beta2_on	0	23.2223	No	Yes	No	No	2	5
101	3x22	E2.E188	beta2_on	1.48037	16.3444	No	Yes	No	No	2	3
102	3x34	4x58	beta2_on	0	13.2267	No	No	No	No	5	4
103	3x40	6x48	beta2_on	0	14.4738	No	No	Yes	Yes	7	8
104	3x50	7x53	beta2_on	0	31.4732	No	Yes	Yes	Yes	9	9
105	5x54	6x44	beta2_on	0	52.1446	No	No	Yes	Yes	8	9
106	5x54	6x41	beta2_on	3.05875	50.8534	No	No	No	No	8	8
107	5x58	6x41	beta2_on	4.53397	50.3055	Yes	Yes	No	No	9	8
108	5x57	5x58	beta2_on	0	51.8423	No	No	Yes	Yes	6	9
109	3x51	5x57	beta2_on	0	49.4993	No	Yes	No	No	8	6
110	3x52	3x56	beta2_on	0	15.3744	No	No	No	No	5	6
111	3x56	I2x52	beta2_on	0	10.2979	No	No	No	No	6	5
112	2x41	4x39	beta2_on	1.4649	11.4253	No	No	No	No	4	1
113	5x36	5x39	beta2_on	2.94527	33.6902	No	No	Yes	Yes	4	6
114	5x36	E2.R175	beta2_on	0	29.6215	No	No	Yes	No	4	2
115	E2.I182	E2.R175	beta2_on	0	25.5023	No	No	Yes	No	1	2
116	E2.H178	E2.I182	beta2_on	0	23.4049	Yes	Yes	No	No	2	1
117	E2.E180	E2.H178	beta2_on	1.37205	10.8144	No	No	Yes	Yes	3	2
118	E2.E188	E2.T189	beta2_on	0	11.6962	No	No	No	No	3	4
119	E2.T195	E2x52	beta2_on	1.38753	10.0082	No	No	Yes	No	3	4
120	5x47	6x49	beta2_on	2.93496	20.4636	Yes	Yes	No	Yes	8	6
121	5x58	6x37	beta2_on	1.49069	55.8166	Yes	Yes	No	No	9	8
122	5x62	6x37	beta2_on	0	53.461	No	Yes	No	No	6	8
123	5x62	6x34	beta2_on	0	10.279	No	Yes	No	No	6	7
124	5x64	5x67	beta2_on	1.53195	10.2979	Yes	Yes	No	No	5	4
125	5x62	5x66	beta2_on	0	37.0347	No	Yes	No	No	6	6
126	5x66	6x30	beta2_on	0	34.5972	No	No	No	No	6	7
127	5x69	6x30	beta2_on	0	29.886	No	No	No	No	5	7
128	5x69	6x29	beta2_on	0	27.543	No	No	No	No	5	6
129	7x33	7x37	beta2_on	0	12.3701	No	No	No	Yes	4	5
130	1x48	1x52	beta2_on	0	13.7306	No	Yes	No	No	4	6
131	5x73	6x29	beta2_on	0	22.5861	No	Yes	No	No	0	6
132	5x72	5x73	beta2_on	0	15.217	No	No	No	Yes	0	0
133	5x72	5x76	beta2_on	0	12.685	No	No	No	Yes	0	0
134	1x50	2x51	beta2_on	0	11.4316	No	Yes	No	No	9	7
135	4x46	4x47	beta2_on	0	11.8284	No	Yes	No	No	8	3
136	4x47	4x51	beta2_on	1.47522	10.5813	No	No	No	No	3	4
137	2x46	2x50	beta2_on	0	54.5506	No	Yes	No	Yes	9	9
138	2x46	7x53	beta2_on	0	64.4706	No	Yes	Yes	Yes	9	9
139	3x50	5x58	beta2_on	0	30.5851	No	Yes	Yes	Yes	9	9
140	5x58	6x40	beta2_on	0	31.8007	Yes	Yes	No	Yes	9	8
141	6x51	6x52	beta2_on	1.15026	17.075	Yes	Yes	Yes	Yes	6	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	beta2_off	5.65286	0	1	0	2	2
2x53	7x42	beta2_off	4.27571	0	1	0	2	1
2x56	3x32	Shared	6.88286	10.2225	1	2	2	1
2x56	7x42	Shared	3.97	4.735	1	2	2	1
2x57	7x42	Shared	3.96857	4.1025	0	0	2	1
2x59	3x24	beta2_off	18.0386	0	3	0	2	2
2x59	3x28	Shared	5.86857	7.2675	3	0	2	1
3x24	E1x50	beta2_off	4.68571	0	3	0	2	2
3x28	E1x50	Shared	11.2471	9.84	3	0	1	2
3x24	3x28	beta2_off	4.95571	0	3	0	2	1
3x29	E2x52	beta2_off	5.74571	0	0	0	2	1
3x32	7x42	Shared	9.35857	10.6325	1	2	1	1
3x32	Lig	Shared	18.62	14.775	1	2	1	0
3x33	4x57	Shared	5.99857	4.8475	0	0	1	2
3x33	Lig	Shared	10.7643	5.9625	0	0	1	0
3x36	6x48	Shared	7.70571	7.6625	1	0	1	1
3x36	Lig	Shared	6.17571	6.695	1	0	1	0
3x37	5x461	Shared	8.90571	7.195	0	0	2	1
3x40	6x44	Shared	6.28	5.65	0	0	2	2
E2.Y174	E2x52	beta2_off	3.98	0	2	4	2	1
5x39	E2.Y174	Shared	6.66714	6.9525	0	4	2	2
E2.T195	E2x52	Shared	7.78	6.81	0	0	2	1
E2x52	Lig	Shared	9.22143	14.945	0	0	1	0
5x39	E2.T195	Shared	5.70714	5.93	0	4	2	2
5x39	5x43	Shared	14.3529	9.5375	0	4	2	1
5x43	Lig	Shared	5.26571	7.44	0	0	1	0
5x44	6x52	Shared	3.77143	3.9625	0	0	2	1
5x461	Lig	Shared	3.73143	5.82	0	0	1	0
5x47	6x52	Shared	33.0686	15.54	0	2	2	1
6x44	6x48	beta2_off	11.8829	0	0	0	2	1
6x44	7x45	beta2_off	7.25	0	0	0	2	2
6x48	6x51	beta2_off	5.15143	0	1	2	1	1
6x48	6x52	Shared	5.3	6.0125	1	2	1	1
6x48	7x41	Shared	12.67	11.26	1	2	1	2
6x48	Lig	beta2_off	3.82143	0	1	2	1	0
6x51	6x52	Shared	6.12429	6.4325	1	2	1	1
6x51	7x34	Shared	11.6414	6.19	1	2	1	2
6x51	7x38	Shared	11.5629	16.31	1	2	1	1
6x51	Lig	Shared	8.38714	3.8325	1	2	1	0
6x52	Lig	Shared	12.2943	7.7125	1	2	1	0
6x55	7x34	Shared	5.81286	8.72	0	2	1	2
6x55	Lig	Shared	9.05857	4.035	0	2	1	0
7x38	7x42	Shared	13.2914	6.1075	1	2	1	1
7x38	Lig	Shared	14.2714	10.44	1	2	1	0
7x39	7x42	Shared	14.7429	6.5125	1	0	2	1
7x42	Lig	Shared	5.23429	3.985	1	2	1	0
2x60	3x28	Shared	3.61714	1.76	0	0	2	1
6x51	7x37	Shared	2.09143	6.6975	1	2	1	2
3x28	Lig	beta2_on	0	3.9025	3	0	1	0
3x40	6x48	beta2_on	0	6.7525	0	0	2	1
7x34	E2x52	beta2_on	0	4.125	0	2	2	1
5x47	6x44	beta2_on	0	6.1625	0	2	2	2
5x47	6x48	beta2_on	0	3.26	0	2	2	1
6x48	7x45	beta2_on	0	7.6275	1	2	1	2
6x51	6x55	beta2_on	0	4.2275	1	2	1	1
6x51	7x40	beta2_on	0	3.7675	1	2	1	2
3x28	3x29	beta2_on	0	2.73	3	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	beta2_off	6PS2-β₂-(S)-Alprenolol 6PS3-β₂-(S)-Carvedilol 6PS5-β₂-(S)-Propranolol 6PS6-β₂-Timolol 2RH1-β₂-(S)-Carazolol 6PS4-β₂-ICI 118-551 3NY9-β₂-PubChem 913103
	beta2_on	3SN6-β₂-BI167107-Gs/&β;1/&γ;2 7DHR-β₂-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2 7DHI-β₂-Salbutamol-Gs/&β;1/&γ;2

Network Difference
Value	beta2_off	beta2_on
I_min	3.71286	3.1
Number of Linked Nodes	275	286
Number of Specific Nodes	6 (2.18%)	17 (5.94%)
Number of Shared Nodes	269 (97.82%)	269 (94.06%)
Number of Links	302	322
Number of Specific Links	120 (39.74%)	140 (43.48%)
Number of Shared Links	182 (60.26%)	182 (56.52%)
Number of Hubs	37	43
Number of Specific Hubs	13 (35.14%)	19 (44.19%)
Number of Shared Hubs	24 (64.86%)	24 (55.81%)
Average % Shared Neighbours (Jaccard)	45.29
Average % Shared Neighbours (Otsuka)	53.59
Average % Shared Neighbours (Overlap Coefficient)	61.96
Average % Shared Cliques (k3-6)	53.66
Graphlets Similarity	0.693382

Paths Difference
Value	beta2_off	beta2_on
Number Of Nodes in MetaPath	75	94
Specific Nodes in MetaPath	26 (34.67%)	45 (47.87%)
Shared Nodes in MetaPath	269 (97.82%)	269 (97.82%)
Number Of Links MetaPath	73	100
Specific Links in MetaPath	41 (56.16%)	68 (68.00%)
Shared Links in MetaPath	182 (60.26%)	182 (60.26%)
Number of Shortest Paths	41422	57191
Length Of Smallest Path	3	3
Average Path Length	15.5598	12.3828
Length of Longest Path	42	28
Minimum Path Strength	0.636429	0.601667
Average Path Strength	6.60888	5.20402
Maximum Path Strength	28.08	15.5712
Minimum Path Correlation	0.701429	0.7
Average Path Correlation	0.922852	0.9327
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	2.7027	4.16667
Average % Of Corr. Nodes	44.1547	55.0101
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.7123	46.1811
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download beta2_off_on.zip<

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