Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.hns1.01 8.451514
2G.S1.02 9.4775416
3G.S2.06 8.18333419
4G.S3.03 6.36472618
5G.S3.05 7.10583418
6G.S3.06 9.04067517
7G.S3.07 4.9675409
8G.s3h2.03 6.41625439
9G.H2.01 6.57439
10G.H2.05 9.00458438
11G.H2.06 8.98067539
12G.H2.07 10.0371439
13G.S4.03 5.36333457
14G.H3.09 6.713336149
15G.H3.13 9.341946146
16G.H3.17 10.1711635
17G.S5.03 7.12958459
18G.S5.04 7.25542409
19G.S5.05 8.49472659
20G.S5.07 4.94233509
21G.hgh4.02 7.35833488
22G.hgh4.05 12.6946406
23G.hgh4.20 5.02458403
24G.hgh4.21 8.86404
25G.H4.03 4.57208404
26G.H4.08 10.54794103
27G.H4.10 10.1383587
28G.H4.14 7.20972685
29G.H4.15 10.7417408
30G.h4s6.12 6.85917402
31G.h4s6.20 8.292504
32G.S6.02 9.059558
33G.S6.04 11.6596459
34G.S6.05 9.482675105
35G.s6h5.01 7.51875459
36G.s6h5.05 8.30208459
37G.H5.03 6.98367559
38G.H5.06 9.52389654
39G.H5.08 6.45472618
40G.H5.17 10.6212405
41G.H5.19 5.39792408
42G.H5.20 4.90333418
43G.H5.23 10.1363514
44G.H5.25 4.12625418
45b.1x3 1.33708408
46b.h2x1 5.14333405
47b.lhb1x6 4.25417403
48b.b1x4 5.65417447
49b.l1x3 10.629549
50b.l1x6 12.6033439
51b.b2x5 8.001507
52b.l3x1 10.7146409
53b.l3x2 8.05042419
54b.b4x4 8.64792448
55b.b4x5 5.200424137
56b.b4x6 10.3374749
57b.b4x7 9.053334128
58b.b5x2 7.4935127
59b.b5x3 7.37278649
60b.b5x5 6.3745135
61b.b5x7 6.44625407
62b.l5x1 5.205335158
63b.l5x5 10.4322619
64b.b6x5 5.49406
65b.b7x1 7.58404
66b.b8x4 7.4035156
67b.l8x5 3.28403
68b.b9x2 8.164535
69b.b9x3 5.35125406
70b.l9x3 7.42083639
71b.l9x6 8.50528638
72b.b10x5 5.61429709
73b.l10x1 7.51458403
74b.b11x1 6.85405
75b.b11x4 5.96333439
76b.l11x2 7.14375439
77b.b12x6 9.14524738
78b.b13x7 9.57042477
79b.l13x3 8.68367579
80b.l13x6 6.94867539
81b.b16x4 9.59576
82b.b16x5 6.48375405
83b.b16x6 8.32429778
84b.b17x5 7.17542407
85b.l17x3 10.6787569
86b.b18x3 5.91833468
87b.b18x5 4.93267505
88b.l18x1 6.0957116
89b.b19x2 8.776566
90b.b19x4 8.29542468
91b.l19x2 8.09583409
92b.b20x4 7.90639608
93b.b20x6 9.37125466
94b.b21x1 4.68958407
95b.b21x2 4.70958406
96b.b21x5 6.54417404
97b.b21x7 7.36667505
98b.b22x5 7.739174117
99b.l22x5 5.69778609
100b.b23x6 8.65695607
101b.l23x1 7.79833436
102b.b24x3 4.94125405
103b.l24x3 4.19792405
104b.l25x3 11.0621499
105b.l25x6 15.7497538
106b.l27x1 13.4129739
107b.l27x2 9.61042499
108b.b28x2 8.71458404
109b.b28x3 5.58875447
110b.b28x4 10.2375496
111b.b28x6 10.7147599
112g.h1x5 1.94875406
113g.l1x4 3.19875408
114g.h2x11 9.024584116
115g.h2x15 7.45375406
116g.ctx6 5.49125406
117g.ctx16 6.73071748
1181x31 4.35833427
1191x49 8.77409
1201x50 4.38042409
1211x57 5.666335169
122I1x50 5.429584168
1232x38 10.9807518
1242x39 10.5208419
1252x42 6.35625419
1262x57 7.60042429
1272x63 2.732508
1283x33 8.20056629
1293x34 7.09333419
1303x35 7.84208409
1313x42 9.49933519
1323x49 8.13067519
133I2 8.904821918
1344x42 11.3403518
1354x46 7.827518
1364x50 7.5175619
137E2 9.112781827
138E2x51 6.62629
139E2x52 7.33267528
1405x40 7.59167529
1415x47 9.85625429
1425x51 6.13333429
143I3 5.22083408
1446x42 9.44917426
1456x47 6.9429
1466x48 10.1036729
1477x37 7.65083429
1487x40 5.08208428
1497x45 7.45417429
1507x47 7.35208427
1517x50 7.64667409
1528x53 5.05467509
153Lig 5.62451020
154NT 10.66961520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.40 b.b5x2 10.39749.345NoYes077
2G.HN.40 b.b5x3 10.94535.945NoYes079
3b.b3x6 b.l1x3 25.663715.3433NoYes099
4b.b3x6 b.l3x2 25.93129.57167NoYes099
5G.hns1.01 b.l3x2 15.78574.40833YesYes149
6G.hns1.01 G.hns1.02 75.4266.00167YesNo144
7G.hns1.02 I2 75.46429.08833NoYes148
8G.S3.03 I2 31.61664.28833YesYes188
9G.S1.04 G.S3.03 20.92717.30833NoYes078
10G.S1.04 G.S4.03 20.79256.18333NoYes077
11G.S1.06 G.S4.03 10.48975.47167NoYes087
12G.S1.06 G.S3.07 19.80133.39333NoYes089
13G.S2.02 G.S3.07 18.3057.16667NoYes059
14G.S2.02 G.hfs2.06 17.69173.965NoNo057
15G.hfs2.06 b.l7x3 17.38482.945NoNo079
16b.l7x3 b.l7x5 16.77079.09833NoNo096
17b.b9x3 b.l7x5 16.15615.46833YesNo066
18b.b5x7 b.b8x4 10.57629.875YesYes076
19b.b4x6 b.l1x3 17.20825.28833YesYes499
20b.l1x4 b.l3x2 12.01511.3067NoYes169
21G.HN.51 b.l1x4 12.16317.05NoNo146
22G.HN.51 I2 12.232415.3267NoYes148
23G.S2.06 G.S3.03 10.697710.8983YesYes198
24G.S2.06 G.S3.05 10.26877.46333YesYes198
25G.S1.03 G.hns1.01 67.090522.12NoYes194
26G.S1.03 b.l5x5 66.00735.33333NoYes199
27G.S4.03 G.S5.05 11.23384.605YesYes579
28b.l3x1 b.l5x5 60.00748.58YesYes099
29G.H2.10 b.l3x1 17.38967.37667NoYes089
30G.H2.10 b.b6x1 17.2824.86NoNo089
31b.b6x1 b.l9x6 34.65126.58667NoYes098
32b.b2x1 b.l3x1 29.774412.21NoYes089
33b.b2x1 b.b6x1 17.59739.18167NoNo089
34b.b2x1 b.l27x1 12.71479.64333NoYes089
35b.l25x6 b.l27x1 20.736631.8217YesYes389
36b.l1x6 b.l27x1 12.417720.89YesYes399
37b.l1x6 b.l3x1 12.815814.6917YesYes099
38b.b22x1 b.l25x6 18.94158.19167NoYes388
39b.b18x1 b.b22x1 18.79814.62833NoNo098
404x42 I2 1008.66333YesYes188
412x42 4x46 20.23434.39333YesYes198
424x42 4x46 37.867113.925YesYes188
432x38 2x42 32.43287.255YesYes189
442x38 4x42 58.486522.835YesYes188
456x43 7x53 10.081715.8917NoNo098
463x46 6x43 10.323111.7067NoNo099
47b.l11x1 b.l9x6 31.22769.65667NoYes398
48b.b11x6 b.l11x1 31.03033.71NoNo399
49b.b11x6 b.l9x3 29.431515.575NoYes399
50b.b11x4 b.l9x3 18.38485.70833YesYes399
51b.b10x3 b.b11x4 18.00074.78833NoYes089
52b.b10x3 b.b6x2 17.73135.07NoNo088
53b.b10x2 b.b6x2 17.19213.09833NoNo068
54b.b10x2 b.b10x4 16.92246.03333NoNo066
55b.b10x4 b.b14x5 16.38223.43833NoNo065
56b.b14x5 b.l10x1 16.11218.76333NoYes053
57b.b11x1 b.l10x1 15.300812.6433YesYes053
58b.b11x1 b.b12x5 13.94638.87333YesNo056
59b.b12x5 b.b13x5 13.40366.38667NoNo064
60b.b13x5 b.b13x7 13.1326.05167NoYes047
61b.b13x7 b.b16x6 11.214816.5367YesYes778
62b.b18x1 b.l19x1 20.11374.71167NoNo099
63b.l17x5 b.l19x1 19.84565.64333NoNo069
64b.l17x5 b.l19x2 19.57746.625NoYes069
65b.b20x2 b.l19x2 14.14226.505NoYes069
66b.b20x2 b.b20x4 13.6048.40833NoYes068
67b.b20x4 b.b20x6 12.265.345YesYes086
682x38 4x43 53.43289.67167YesNo088
692x41 4x43 53.381219.385NoNo098
702x41 I1x51 53.329611.5517NoNo099
71I1x48 I1x51 53.27798.72333NoNo069
72I1 I1x48 53.2265.42833NoNo086
73I1 b.l25x4 21.21475.36NoNo085
74b.l25x4 b.l27x2 21.143510.425NoYes059
75b.l25x3 b.l27x2 41.957810.2933YesYes999
76b.b27x3 b.l25x3 20.81435.25167NoYes089
77b.b27x3 b.b28x6 20.64218.49NoYes089
78b.b25x7 b.b28x6 50.732325.0583NoYes079
79b.b24x3 b.b25x7 49.84837.145YesNo057
80b.b24x3 b.b26x3 48.52154.23333YesNo056
81b.b23x3 b.b26x3 47.63635.07167NoNo076
82b.b23x3 b.b24x5 45.42124.47NoNo075
83b.b23x1 b.b24x5 44.53425.46333NoNo055
84b.b23x1 b.l22x1 43.64687.25833NoNo059
85b.l22x1 g.ctx3 43.20296.625NoNo099
86g.ctx3 g.ctx6 42.31469.5NoYes096
87b.l22x5 g.ctx6 36.48665.67YesYes096
88b.l22x5 b.l24x2 30.69636.27667YesNo096
89b.h2x1 b.l24x2 29.8063.92YesNo056
90b.b21x5 b.h2x1 26.65476.125YesYes045
91I1 b.b28x2 31.95955.52333NoYes084
92b.b28x2 b.l27x2 21.158611.3433YesYes049
93b.b28x4 b.l25x3 20.99412.6633YesYes969
94b.b28x4 b.b28x6 30.96676.76667YesYes969
95b.b28x2 b.l1x1 10.66929.62333YesNo047
96b.b1x5 b.l1x1 10.586813.3667NoNo037
97b.b1x5 b.b28x4 10.504710.76NoYes036
98b.b21x5 b.b21x7 22.166410.3783YesYes045
99b.b21x7 b.b23x2 12.25973.32333YesNo056
100b.b22x5 b.b23x2 11.807315.4267YesNo076
1012x57 NT 17.59813.0167YesYes290
1022x57 3x32 27.91327.10833YesNo099
1032x56 3x32 56.99574.40667NoNo069
1042x56 3x35 57.2165.105NoYes069
1053x34 3x35 57.88077.735YesYes099
1063x34 4x50 58.5277.55667YesYes199
1073x42 4x50 63.697513.2767YesYes199
1082x42 3x42 46.96946.26333YesYes199
109E2x51 NT 17.59777.65YesYes290
1103x32 E2x51 28.86567.78NoYes099
1113x42 3x45 17.45427.97167YesNo099
1123x45 4x46 17.74311.3683NoYes098
1137x42 NT 10.7479.51167NoYes280
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x573x327.108332YesNo9912
2x57E24.681672YesYes9711
2x57Lig5.5952YesYes9010
2x60E210.79832NoYes9721
3x25E25.0152NoYes9721
3x26E24.526672NoYes9721
3x30E26.308330NoYes6721
3x32E2x517.780NoYes9921
3x33E212.70672YesYes9721
3x33E2x529.723332YesYes9822
4x60E29.322NoYes8721
4x64E24.653330NoYes6721
E2E220.21832YesYes7711
5x39E216.762NoYes7721
E2E2x528.528332YesYes7812
E2Lig9.2352YesYes7010
E2E2x514.843332YesYes7911
5x40E2x517.016672YesYes9911
E2x51Lig5.192YesYes9010
5x39E2x525.728332NoYes7822
5x40E2x525.443332YesYes9812
5x405x439.182YesNo9912
5x40Lig6.12YesYes9010
6x487x375.512YesYes9921
6x487x4126.36672YesNo9922
7x377x4112.0852YesNo9912
7x37Lig5.066672YesYes9010
NTNT22.79672YesYes0022
2x57NT13.01672YesYes9012
E2NT16.872YesYes7012
6x48NT9.576672YesYes9022
7x37NT7.941672YesYes9012
E2x51NT7.652YesYes9012
5x40NT10.21832YesYes9012
3x334x605.022YesNo9822
E2x51E2x527.242YesYes9812
1x39Lig4.253332NoYes9010
3x29E24.188330NoYes9721
4x61E23.926670NoYes8721
5x37Lig3.6152NoYes6010
6x55E33.156672NoNo8812
5x375x382.9452NoNo6512
6x55Lig2.772NoYes8010
1x397x382.242NoNo9712
4x63E21.231672NoYes5721

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
40.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
40.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
36.36Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
35.71Single4QIMANTA XV4QIM-SMO-ANTA XV
33.33Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
31.25Single5V56TC1145V56-SMO-TC114
30.77Single5ZKQABT-4915ZKQ-PAF-ABT-491
30.77Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
30.77Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
30.77Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
30.77Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
30.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
28.57Single6MH8ZM-2413856MH8-A2A-ZM-241385
28.57Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
28.57Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
28.57Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
26.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
26.67Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.67Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
26.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
26.67Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
26.32Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
25.00Single4JKVTaladegib4JKV-SMO-Taladegib
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
25.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
25.00Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
25.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
25.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
25.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
23.81Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.53Single5V57TC1145V57-SMO-TC114
23.53Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
23.53Single7PX4PSB-21137PX4-A2A-PSB-2113
23.53Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.53Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.53Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
23.53Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
23.08Single6LI0C176LI0-GPR52-C17
23.08Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.08Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
23.08Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
23.08Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
23.08Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
23.08Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.08Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
23.08Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
23.08Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
23.08Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
23.08Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.08Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
22.22Single4N4WSANT-14N4W-SMO-SANT-1
22.22Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
22.22Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.22Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.22Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.22Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
22.22Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.43Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single3PWHZM-2413853PWH-A2A-ZM-241385
21.43Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
21.43Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.43Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.43Single5U09Taranabant5U09-CB1-Taranabant
21.43Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
21.43Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.43Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.43Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.43Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.43Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.43Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
21.43Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
21.43Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.43Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.43Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
21.43Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
21.43Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.43Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
21.43Single9H2XA1IR19H2X-A2A-A1IR1-Na
21.05Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
21.05Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.05Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
21.05Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
21.05Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
21.05Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.05Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.05Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.83Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.83Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM-2413855JTB-A2A-ZM-241385
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6AQFZM-2413856AQF-A2A-ZM-241385
20.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single7AROLUF58337ARO-A2A-LUF5833-Na
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
20.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
20.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
20.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
20.00Consensusa2_offOrthosteric Liganda2a_off
20.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.05Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
19.05Single7QA8Peptide7QA8-STE2-Peptide
19.05Single7QA8Peptide7QA8-STE2-Peptide
19.05Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.05Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IEBA1LYA8IEB-GPR156-A1LYA
19.05Single8IEIA1LYA8IEI-GPR156-A1LYA
19.05Single8IEPA1LYA8IEP-GPR156-A1LYA
19.05Single8IEPA1LYA8IEP-GPR156-A1LYA
19.05Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
19.05Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
19.05Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.05Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single3EMLZM-2413853EML-A2A-ZM-241385
18.75Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
18.75Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
18.75Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.75Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
18.75Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
18.75Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
18.75Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
18.75Single5UENDU1725UEN-A1-DU172
18.75Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
18.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.75Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.75Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.75Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
18.75Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
18.75Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
18.75Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
18.75Single6S0LZM-2413856S0L-A2A-ZM-241385
18.75Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
18.75Single7PYRPSB-21157PYR-A2A-PSB-2115
18.75Single8CU6LJ-45178CU6-A2A-LJ-4517
18.75Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
18.75Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.75Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
18.75Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
18.75Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
18.75Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
18.75Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
18.75Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
18.75Single9H37A1IR09H37-A2A-A1IR0-Na
18.75Consensusa3_onOrthosteric Liganda3a_on
18.75Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
18.75Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.75Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
18.18Single3QAKUK-4320973QAK-A2A-UK-432097
18.18Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.18Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
18.18Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
18.18Single8IEBA1LYA8IEB-GPR156-A1LYA
18.18Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
18.18Single8PWNTheophylline8PWN-A2A-Theophylline
18.18Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.18Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
18.18Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.18Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
18.18Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.65Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.65Single5N2RPSB-365N2R-A2A-PSB-36-Na
17.65Single5N2SPSB365N2S-A1-PSB36
17.65Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
17.65Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
17.65Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
17.65Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
17.65Single6S0QZM-2413856S0Q-A2A-ZM-241385
17.65Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
17.65Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
17.65Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.65Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
17.65Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
17.65Single7SINNPS-21437SIN-CaS-NPS-2143
17.65Single7SINNPS-21437SIN-CaS-NPS-2143
17.65Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
17.65Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
17.65Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.65Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
17.65Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.65Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
17.65Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
17.65Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
17.65Single8QOTNanobody-E8QOT-μ-Nanobody-E
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
17.65Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
17.65Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
17.65Single9B9ZA1AKO9B9Z-CB1-A1AKO
17.65Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
17.65Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
17.65Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.65Consensusa3_on_gpOrthosteric Liganda3a_on_gp
17.65Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.65Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.65Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.65Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.65Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.65Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
17.65Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
17.65Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
17.65Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.65Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.39Single5WF5UK-4320975WF5-A2A-UK-432097
17.39Single6W25SHU91196W25-MC4-SHU9119-Ca
17.39Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.39Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.39Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.39Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.39Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
17.39Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
17.39Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
17.39Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.39Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.39Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.39Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
17.39Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.39Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.39Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
17.39Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
16.67Single3RFMCaffeine3RFM-A2A-Caffeine
16.67Single5TZRMK86665TZR-FFA1-MK8666
16.67Single5XRAAM115425XRA-CB1-AM11542
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6J21Aprepitant6J21-NK1-Aprepitant
16.67Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
16.67Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
16.67Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
16.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.67Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
16.67Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
16.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
16.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.67Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
16.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
16.67Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
16.67Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
16.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
16.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.67Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
16.67Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
16.67Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
16.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
16.67Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
16.67Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
16.67Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
16.67Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
16.67Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.67Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
16.67Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
16.67Consensusa2_onOrthosteric Liganda2b_on
16.67Consensusa2_on_gpOrthosteric Liganda2b_on_gp
16.67Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
16.67Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
16.67Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
16.67Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
16.67Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
16.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
16.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Consensusrelaxin_onOrthosteric Ligandrxfp4_on
16.67Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
16.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
16.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
16.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
16.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
16.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
16.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
16.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
16.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
16.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
15.79Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
15.79Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
15.79Single4RWADIPP-NH24RWA-δ-DIPP-NH2
15.79Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
15.79Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.79Single6IIURamatroban6IIU-TXA2-Ramatroban
15.79Single6KQICP559406KQI-CB1-CP55940-Org27569
15.79Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
15.79Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
15.79Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.79Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
15.79Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.79Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
15.79Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
15.79Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.79Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
15.79Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.79Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
15.79Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
15.79Single8JWY2-1188JWY-A2A-2-118
15.79Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
15.79Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
15.79Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
15.79Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8XQJJN2418XQJ-Apelin-JN241
15.79Single8XWACXCL18XWA-CXCR2-CXCL1
15.79Single8XWMCXCL68XWM-CXCR2-CXCL6
15.79Single8XWSCXCL58XWS-CXCR2-CXCL5
15.79Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
15.79Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
15.79Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
15.79Single9DGIZ85267113509DGI-CB1-Z8526711350
15.79Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
15.79Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
15.79Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.79Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.79Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
15.79Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.79Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.79Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.79Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
15.79Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.79Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
15.79Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
15.79Consensuslpl_offOrthosteric Ligands1p_off lpa_off
15.79Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
15.79Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.79Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
15.38Single3OE6IT1t3OE6-CXCR4-IT1t
15.38Single3UZAGTPL92363UZA-A2A-GTPL9236
15.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.38Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.38Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
15.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.38Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.38Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.38Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
15.38Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
15.38Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
15.38Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.38Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
15.38Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
15.38Single7WC5Psilocin7WC5-5-HT2A-Psilocin
15.38Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
15.38Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.38Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
15.38Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
15.38Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.38Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
15.38Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
15.38Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
15.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.38Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.38Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
15.38Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.38Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
15.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
15.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
15.00Single7EZCUKA7EZC-A2A-UKA
15.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
15.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
15.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
15.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
15.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
15.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
15.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
15.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
15.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8XVUCXCL28XVU-CXCR2-CXCL2
15.00Single8XWFCXCL38XWF-CXCR2-CXCL3
15.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
15.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
15.00Single8ZPLHF511168ZPL-CXCR4-HF51116
15.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
15.00Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
15.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.00Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
15.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
15.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
15.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.00Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
14.81Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
14.81Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.81Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
14.81Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.81Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
14.81Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
14.81Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.81Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.81Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
14.81Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
14.81Single9KDFRES-701-39KDF-ETB-RES-701-3
14.81Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.81Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
14.81Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.81Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
14.29Single3NY9ICI118-5513NY9-β2-ICI118-551
14.29Single3OE9IT1t3OE9-CXCR4-IT1t
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5WF6UK-4320975WF6-A2A-UK-432097
14.29Single5ZTYAM102575ZTY-CB2-AM10257
14.29Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
14.29Single6HLLCP999946HLL-NK1-CP99994
14.29Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
14.29Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
14.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
14.29Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
14.29Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.29Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
14.29Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
14.29Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
14.29Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
14.29Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.29Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.29Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
14.29Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
14.29Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
14.29Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
14.29Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
14.29Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.29Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
14.29Single8QJ2pN1628QJ2-MC4-pN162-Gs
14.29Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.29Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
14.29Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.29Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
14.29Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.29Single9B9Y7DY9B9Y-CB1-7DY
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
14.29Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
14.29Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
14.29Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensusbradykinin_onOrthosteric Ligandbk2_on
14.29Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
14.29Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
14.29Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
14.29Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29Consensusgq_nucleotideOrthosteric Ligandgq_p2y
14.29Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
14.29Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.79Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
13.79Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
13.79Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.79Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
13.79Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
13.79Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
13.64Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.64Single4XT1Fractalkine4XT1-US28-Fractalkine
13.64Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.64Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
13.64Single7F8XNN90567F8X-CCKA-NN9056
13.64Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
13.64Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
13.64Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
13.64Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
13.64Single8IEIA1LYA8IEI-GPR156-A1LYA
13.64Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
13.64Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.64Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.64Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
13.64Single8WDTphotoNECA8WDT-A2A-photoNECA
13.64Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8XWNCXCL88XWN-CXCR2-CXCL8
13.64Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.64Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
13.64Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
13.64Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
13.64Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.64Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
13.64Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.64Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
13.64Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.64Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.64Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
13.64Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Single3ODUIT1t3ODU-CXCR4-IT1t
13.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
13.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
13.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single6AKXA4R6AKX-CCR5-A4R
13.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
13.33Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
13.33Single6ME9Ramelteon6ME9-MT2-Ramelteon
13.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
13.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
13.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.33Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
13.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
13.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
13.33Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
13.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
13.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
13.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
13.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
13.33Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
13.33Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
13.33Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
13.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
13.33Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
13.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
13.33Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
13.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
13.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
13.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.04Single6HLOAprepitant6HLO-NK1-Aprepitant
13.04Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.04Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
13.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
13.04Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.04Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
13.04Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
13.04Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
13.04Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
13.04Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
13.04Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.04Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
13.04Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
13.04Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
13.04Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
13.04Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
13.04Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
13.04Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.04Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.04Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.04Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.04Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
12.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.90Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.90Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.50Single2YDOAdenosine2YDO-A2A-Adenosine
12.50Single3OE0CVX153OE0-CXCR4-CVX15
12.50Single3REYXAC3REY-A2A-XAC
12.50Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
12.50Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
12.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
12.50Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
12.50Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
12.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
12.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.50Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
12.50Single6TPKRetosiban6TPK-OT-Retosiban
12.50Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
12.50Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
12.50Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
12.50Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.50Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
12.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
12.50Single7F61PF-036547467F61-H3-PF-03654746
12.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
12.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
12.50Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
12.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
12.50Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
12.50Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
12.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
12.50Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
12.50Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.50Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
12.50Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
12.50Single8IHKAcifran8IHK-HCA3-Acifran
12.50Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
12.50Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
12.50Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
12.50Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
12.50Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
12.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
12.50Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
12.50Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
12.50Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
12.50Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.50Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
12.50Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
12.50Single8ZPMAMD0708ZPM-CXCR4-AMD070
12.50Single9ARXSerotonin9ARX-5-HT2A-Serotonin
12.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9BA0A1AKN9BA0-CB1-A1AKN
12.50Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
12.50Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
12.50Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
12.50Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
12.50Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
12.50Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.50Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
12.50Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
12.50Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
12.50Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.50Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.50Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
12.50Consensushca_onOrthosteric Ligandhca2_on
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
12.50Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
12.50Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.50Consensusvasop-oxy_offOrthosteric Ligandot_off
12.12Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
12.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
12.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
12.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
12.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
12.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
12.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
12.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
12.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
12.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
12.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
12.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
12.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
12.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
12.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
12.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
12.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
12.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
11.76Single2Y02Carmoterol2Y02-β1-Carmoterol
11.76Single4EJ4Naltrindole4EJ4-δ-Naltrindole
11.76Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
11.76Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
11.76Single5TGZAM65385TGZ-CB1-AM6538
11.76Single5UIGCmpd-15UIG-A2A-Cmpd-1
11.76Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.76Single6IIVDaltroban6IIV-TXA2-Daltroban
11.76Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
11.76Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
11.76Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
11.76Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
11.76Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
11.76Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
11.76Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
11.76Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
11.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
11.76Single7V3ZCP559407V3Z-CB1-CP55940
11.76Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
11.76Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.76Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
11.76Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
11.76Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.76Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
11.76Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.76Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
11.76Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
11.76Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
11.76Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
11.76Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
11.76Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
11.76Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
11.76Single9CHXS-Carazolol9CHX-β2-S-Carazolol
11.76Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
11.76Single9IYAONO-97105319IYA-GPR55-ONO-9710531
11.76Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
11.76Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
11.76Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
11.76Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
11.76Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
11.76Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
11.76Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
11.76Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
11.76Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
11.76Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
11.76Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
11.76Consensushca_on_gpOrthosteric Ligandhca2_on_gp
11.76Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.76Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.76Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
11.76Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
11.54Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
11.54Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
11.54Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
11.54Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
11.54Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
11.54Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
11.54Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
11.54Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
11.54Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
11.54Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
11.54Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
11.54Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
11.54Consensuspac_onOrthosteric Ligandpac1_on
11.54Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
11.54Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
11.43Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
11.11Single4NTJAZD12834NTJ-P2Y12-AZD1283
11.11Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
11.11Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
11.11Single4XT3Fractalkine4XT3-US28-Fractalkine
11.11Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
11.11Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.11Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.11Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
11.11Single6D26Fevipiprant6D26-DP2-Fevipiprant
11.11Single6FJ3PTH6FJ3-PTH1-PTH
11.11Single6HLPNetupitant6HLP-NK1-Netupitant
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.11Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
11.11Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
11.11Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
11.11Single6Z4SSR486926Z4S-NTS1-SR48692
11.11Single7C61Ergotamine7C61-5-HT1B-Ergotamine
11.11Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
11.11Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
11.11Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
11.11Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.11Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
11.11Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
11.11Single7W41PD1762527W41-BB2-PD176252
11.11Single7WC6LSD7WC6-5-HT2A-LSD
11.11Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.11Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
11.11Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
11.11Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
11.11Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
11.11Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
11.11Single8S4DCMF-0198S4D-Apelin-CMF-019
11.11Single8TF5Oleic acid8TF5-GPR6-Oleic acid
11.11Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
11.11Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
11.11Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
11.11Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
11.11Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
11.11Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
11.11Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
11.11Single9EHSLUF76029EHS-A3A-LUF7602
11.11Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
11.11Single9HAPTolvaptan9HAP-V2-Tolvaptan
11.11Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
11.11Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
11.11Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
11.11Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
11.11Consensusbombesin_offOrthosteric Ligandbb2_off
11.11Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
11.11Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
11.11Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
11.11Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
11.11Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
11.11Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
11.11Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
11.11Consensusdp_offOrthosteric Liganddp2_off
11.11Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.11Consensusep_offOrthosteric Ligandep4_off
11.11Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
11.11Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
11.11Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
11.11Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.11Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
11.11Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
11.11Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.11Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
11.11Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
11.11Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
11.11Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
10.71Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.71Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
10.71Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
10.71Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.71Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
10.71Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
10.71Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
10.71Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
10.71Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
10.71Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
10.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
10.71Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
10.71Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
10.71Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
10.53Single2YDVNECA2YDV-A2A-NECA
10.53Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
10.53Single4BV0Neurotensin4BV0-NTS1-Neurotensin
10.53Single4UHRCGS216804UHR-A2A-CGS21680
10.53Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
10.53Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
10.53Single5G53NECA5G53-A2A-NECA-Gs
10.53Single5XR8AM8415XR8-CB1-AM841
10.53Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.53Single6E59L-7607356E59-NK1-L-760735
10.53Single6J20Aprepitant6J20-NK1-Aprepitant
10.53Single6OS1TRV0266OS1-AT1-TRV026
10.53Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
10.53Single6WGTLSD6WGT-5-HT2A-LSD
10.53Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
10.53Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
10.53Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.53Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
10.53Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
10.53Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
10.53Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
10.53Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
10.53Single7R0CAVP7R0C-V2-AVP-Arrestin2
10.53Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.53Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
10.53Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
10.53Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
10.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
10.53Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
10.53Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
10.53Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.53Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
10.53Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
10.53Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
10.53Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
10.53Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
10.53Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
10.53Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
10.53Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
10.53Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
10.53Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
10.53Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.53Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
10.53Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
10.53Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
10.53Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
10.53Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
10.53Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.53Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
10.53Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
10.53Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
10.53Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
10.53Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
10.53Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.53Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
10.53Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.53Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
10.53Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
10.53Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
10.53Consensusneurotensin_onOrthosteric Ligandnts1_on
10.53Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.53Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
10.53Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
10.53Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Consensustachykinin_offOrthosteric Ligandnk1_off
10.34Single6IGLIRL16206IGL-ETB-IRL1620
10.34Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.34Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
10.34Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
10.34Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.34Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.34Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
10.34Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
10.34Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.34Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.34Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
10.34Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.34Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
10.34Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.34Consensusendothelin_onOrthosteric Ligandetb_on eta_on
10.34Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.34Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
10.34Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
10.34Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.34Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
10.26Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
10.00Single4AMIBucindolol4AMI-β1-Bucindolol
10.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
10.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
10.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
10.00Single4XESNeurotensin4XES-NTS1-Neurotensin
10.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
10.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
10.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
10.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
10.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
10.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
10.00Single6MXTSalmeterol6MXT-β2-Salmeterol
10.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
10.00Single6OS2TRV0266OS2-AT1-TRV026
10.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
10.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
10.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
10.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
10.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
10.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
10.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
10.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Single7YITNalfurafine7YIT-κ-Nalfurafine
10.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
10.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
10.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
10.00Single8JJLOlodaterol8JJL-β2-Olodaterol
10.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
10.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
10.00Single8JWZAB9288JWZ-A2A-AB928-Na
10.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
10.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
10.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
10.00Single8XYIVUF106618XYI-CXCR3-VUF10661
10.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
10.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
10.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
10.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
10.00Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
10.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
10.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
10.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
10.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
10.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
10.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.00Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
10.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
10.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
10.00Consensuslpa_offOrthosteric Ligandlpa1_off
10.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
10.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
9.68Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.68Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
9.68Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.68Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
9.68Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
9.68Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
9.68Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
9.68Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.68Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
9.52Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
9.52Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.52Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
9.52Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
9.52Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.52Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
9.52Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
9.52Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
9.52Single6IBLArformoterol6IBL-β1-Arformoterol
9.52Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
9.52Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
9.52Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
9.52Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
9.52Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
9.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
9.52Single7UM4AS26747237UM4-5-HT5A-AS2674723
9.52Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
9.52Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
9.52Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
9.52Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
9.52Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
9.52Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
9.52Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
9.52Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
9.52Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
9.52Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
9.52Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
9.52Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
9.52Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.52Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
9.52Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.52Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
9.52Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
9.52Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
9.52Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
9.52Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuschemerin_onOrthosteric Ligandcml1_on
9.52Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
9.52Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
9.52Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
9.52Consensusprostanoid_offOrthosteric Ligandep_off dp_off
9.38Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
9.38Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
9.38Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
9.38Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
9.38Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
9.38Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
9.09Single4UG2CGS216804UG2-A2A-CGS21680
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
9.09Single6KNMJN241-96KNM-Apelin-JN241-9
9.09Single6PT3DPI-2876PT3-δ-DPI-287
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
9.09Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
9.09Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.09Single7XN9L-054,5227XN9-SST2-L-054,522
9.09Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
9.09Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
9.09Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
9.09Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
9.09Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
9.09Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
9.09Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
9.09Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
9.09Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
9.09Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
9.09Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
9.09Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
9.09Single9IPYJR14a9IPY-C3aB-JR14a
9.09Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
9.09Single9JF4PD1683689JF4-BB1-PD168368
9.09Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
9.09Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
9.09Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
9.09Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
9.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
9.09Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
9.09Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
9.09Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
9.09Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.09Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.82Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.70Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
8.70Single4IARErgotamine4IAR-5-HT1B-Ergotamine
8.70Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
8.70Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.70Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
8.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.70Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
8.70Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.70Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
8.70Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
8.70Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
8.70Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.70Single8KIGSHU91198KIG-MC3-SHU9119-Ca
8.70Single8WKYPG-9348WKY-MC4-PG-934
8.70Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
8.70Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
8.70Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
8.70Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
8.70Single9M4TSilodosin9M4T-Alpha1A-Silodosin
8.70Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.70Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.70Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
8.70Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
8.70Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.70Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
8.70Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
8.70Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.70Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.70Consensuslpl_onOrthosteric Ligands1p_on lpa_on
8.70Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
8.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
8.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
8.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
8.33Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
8.33Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
8.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
8.33Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
8.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
8.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
8.33Single7XNACYN1548067XNA-SST2-CYN154806
8.33Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
8.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
8.33Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
8.33Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
8.33Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
8.33Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.33Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
8.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
8.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
8.33Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
8.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.11Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
8.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
8.00Single6PT2KGCHM076PT2-δ-KGCHM07
8.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
8.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
8.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
8.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
8.00Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
8.00Consensusangiotensin_onOrthosteric Ligandat1_on
8.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
8.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
8.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
8.00Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
8.00Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
8.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
7.89Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
7.69Single6JODAngiotensin II6JOD-AT2-Angiotensin II
7.69Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.69Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
7.69Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
7.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.69Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
7.69Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
7.69Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
7.69Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.69Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.69Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.69Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
7.69Consensusp2y_offOrthosteric Ligandp2y1_off
7.69Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
7.69Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
7.69Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
7.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.41Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.41Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
7.41Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
7.41Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
7.41Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
7.41Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.41Single8ZRTET-18ZRT-ETB-ET-1
7.41Consensuscalcitonin_onOrthosteric Ligandctlike_on
7.41Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
7.41Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
7.41Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
7.41Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.14Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.14Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.14Single4XNWMRS25004XNW-P2Y1-MRS2500
7.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
7.14Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
7.14Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7SK3CXCL127SK3-ACKR3-CXCL12
7.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
7.14Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
7.14Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
7.14Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.14Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.14Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
7.14Consensus5ht2_onOrthosteric Ligand5ht2b_on
7.14Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
7.14Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
7.14Consensusgi_sensoryOrthosteric Ligandgi_opsins
7.14Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.14Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.14Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
6.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.90Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
6.90Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
6.90Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
6.90Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.90Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
6.90Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67Single3PBLEticlopride3PBL-D3-Eticlopride
6.67Single4O9RCyclopamine4O9R-SMO-Cyclopamine
6.67Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
6.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
6.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.67Single7SRQLSD7SRQ-5-HT2B-LSD
6.67Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
6.67Single7UL2SR486927UL2-NTS1-SR48692-Na
6.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
6.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
6.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
6.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
6.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
6.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
6.67Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.67Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.67Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
6.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
6.67Single8K5BNiacin8K5B-HCA2-Niacin
6.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
6.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
6.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.67Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.67Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
6.67Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
6.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.67Consensusneurotensin_offOrthosteric Ligandnts1_off
6.67Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.45Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.45Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.45Consensusbombesin_onOrthosteric Ligandbb2_on
6.45Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
6.45Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
6.45Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.25Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.25Single4BWBNeurotensin4BWB-NTS1-Neurotensin
6.25Single4QINSAG1.54QIN-SMO-SAG1.5
6.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.25Single5WS3EMPA5WS3-OX2-EMPA
6.25Single6AKYMaraviroc6AKY-CCR5-Maraviroc
6.25Single6B73MP11046B73-κ-MP1104
6.25Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.25Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
6.25Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.25Single6TODEMPA6TOD-OX1-EMPA-Na
6.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.25Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
6.25Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.25Single7BR3Elagolix7BR3-GnRH1-Elagolix
6.25Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
6.25Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
6.25Single7F8ULintitript7F8U-CCKA-Lintitript
6.25Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.25Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.25Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
6.25Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
6.25Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.25Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
6.25Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
6.25Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.25Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
6.25Single7XRRLemborexant7XRR-OX2-Lemborexant
6.25Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.25Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
6.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
6.25Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.25Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.25Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
6.25Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.25Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
6.25Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
6.25Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.25Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
6.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.25Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.25Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.25Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.25Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
6.25Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.25Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
6.25Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
6.25Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
6.25Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
6.25Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
6.25Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.25Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
6.25Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.25Consensusalpha2_offOrthosteric Ligandalpha2c_off
6.25Consensusangiotensin_offOrthosteric Ligandat1_off
6.25Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.25Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.25Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.25Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
6.25Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.25Consensusorexin_offOrthosteric Ligandox2_off ox1_off
6.25Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.25Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
6.25Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.25Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.88Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.88Single3RZECidoxepin3RZE-H1-Cidoxepin
5.88Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
5.88Single4ZJCSB-6740424ZJC-OX1-SB-674042
5.88Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.88Single6IQLL7458706IQL-D4-L745870
5.88Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
5.88Single6KUXRS-799486KUX-α2a-RS-79948
5.88Single6PS0S-Carazolol6PS0-β2-S-Carazolol
5.88Single6PS4ICI118-5516PS4-β2-ICI118-551
5.88Single6PS5S-Propranolol6PS5-β2-S-Propranolol
5.88Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
5.88Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
5.88Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.88Single6TPGEMPA6TPG-OX2-EMPA
5.88Single6TPNHTL66416TPN-OX2-HTL6641
5.88Single6V9SGTPL114036V9S-OX1-GTPL11403
5.88Single6VI4JDTic6VI4-κ-JDTic
5.88Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.88Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.88Single6ZINSR486926ZIN-NTS1-SR48692
5.88Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
5.88Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
5.88Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
5.88Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
5.88Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
5.88Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
5.88Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single7T32ZM-2413857T32-A2A-ZM-241385
5.88Single7UL3Famotidine7UL3-H2-Famotidine
5.88Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.88Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.88Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
5.88Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
5.88Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
5.88Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
5.88Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
5.88Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.88Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.88Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.88Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.88Single8K2WAMG4878K2W-CXCR3-AMG487
5.88Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8K5CAcipimox8K5C-HCA2-Acipimox
5.88Single8RLNLUF58348RLN-A2A-LUF5834
5.88Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
5.88Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
5.88Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.88Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.88Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
5.88Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
5.88Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
5.88Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
5.88Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.88Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
5.88Single8ZPNAMD31008ZPN-CXCR4-AMD3100
5.88Single9AS3LSD9AS3-5-HT2A-LSD
5.88Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AS5Mescaline9AS5-5-HT2A-Mescaline
5.88Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
5.88Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
5.88Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
5.88Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
5.88Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.88Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
5.88Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
5.88Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.88Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
5.88Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.88Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.88Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
5.88Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
5.88Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.88Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.88Consensusgrh_offOrthosteric Ligandgnrh1_off
5.88Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.88Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.88Consensussensory_offOrthosteric Ligandopsins_off
5.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
5.56Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
5.56Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
5.56Single3NY8ICI118-5513NY8-β2-ICI118-551
5.56Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
5.56Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
5.56Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.56Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
5.56Single4GBRS-Carazolol4GBR-β2-S-Carazolol
5.56Single4YAYZD-71554YAY-AT1-ZD-7155
5.56Single5DHGC-355DHG-NOP-C-35
5.56Single5DHHSB-6121115DHH-NOP-SB-612111
5.56Single5T04Neurotensin5T04-NTS1-Neurotensin
5.56Single6D27CAY104716D27-DP2-CAY10471
5.56Single6DRXLisuride6DRX-5-HT2B-Lisuride
5.56Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
5.56Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.56Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
5.56Single6PS1Timolol6PS1-β2-Timolol
5.56Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
5.56Single6TOTLemborexant6TOT-OX1-Lemborexant
5.56Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
5.56Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
5.56Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
5.56Single7BU7BI1671077BU7-β1-BI167107
5.56Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Single7F83PF-051904577F83-Ghrelin-PF-05190457
5.56Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.56Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.56Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
5.56Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
5.56Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
5.56Single7UL4Alvimopan7UL4-μ-Alvimopan
5.56Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
5.56Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.56Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
5.56Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
5.56Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
5.56Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.56Single7YXAONO-54306087YXA-S1P5-ONO-5430608
5.56Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.56Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
5.56Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
5.56Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
5.56Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
5.56Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
5.56Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
5.56Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
5.56Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
5.56Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
5.56Single8JJOAlprenolol8JJO-β2-Alprenolol
5.56Single8K5DGSK2560738K5D-HCA2-GSK256073
5.56Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.56Single8T1WCVN4248T1W-GPR6-CVN424
5.56Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.56Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
5.56Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.56Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
5.56Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.56Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56Single8X63Mepyramine8X63-H1-Mepyramine
5.56Single8X64Desloratadine8X64-H1-Desloratadine
5.56Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
5.56Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.56Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
5.56Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
5.56Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
5.56Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
5.56Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
5.56Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
5.56Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
5.56Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
5.56Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
5.56Consensus5ht5_onOrthosteric Ligand5ht5a_on
5.56Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.56Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
5.56Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
5.56Consensusalpha2_onOrthosteric Ligandalpha2b_on
5.56Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
5.56Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.56Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
5.56Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
5.56Consensuscck_offOrthosteric Ligandccka_off
5.56Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
5.56Consensusdopamine_offOrthosteric Ligandd2_off d3_off
5.56Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
5.56Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
5.56Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
5.56Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.56Consensushistamine_offOrthosteric Ligandh1_off
5.56Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
5.26Single2RH1S-Carazolol2RH1-β2-S-Carazolol
5.26Single2YCWS-Carazolol2YCW-β1-S-Carazolol
5.26Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
5.26Single5C1MBU725C1M-μ-BU72
5.26Single5D6LS-Carazolol5D6L-β2-S-Carazolol
5.26Single5JQHS-Carazolol5JQH-β2-S-Carazolol
5.26Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
5.26Single5TVNLSD5TVN-5-HT2B-LSD
5.26Single5WQCEMPA5WQC-OX2-EMPA
5.26Single5XPRBosentan5XPR-ETB-Bosentan
5.26Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
5.26Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.26Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
5.26Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
5.26Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
5.26Single6PS6Timolol6PS6-β2-Timolol
5.26Single6TP6Filorexant6TP6-OX1-Filorexant
5.26Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
5.26Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
5.26Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
5.26Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
5.26Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.26Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
5.26Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
5.26Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.26Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
5.26Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
5.26Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.26Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.26Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
5.26Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
5.26Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
5.26Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
5.26Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.26Single8JXSPF-61428JXS-D1-PF-6142
5.26Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
5.26Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
5.26Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.26Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
5.26Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
5.26Single9HC04YI9HC0-mGlu5-4YI
5.26Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
5.26Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
5.26Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
5.26Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
5.26Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
5.26Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
5.26Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.26Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
5.26Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
5.26Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
5.26Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
5.26Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
5.26Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
5.26Consensusamine_offonOrthosteric Ligandamine_off amine_on
5.26Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
5.26Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
5.26Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
5.26Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
5.26Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
5.26Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.26Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.26Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
5.26Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
5.26Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Consensustrace-amine_onOrthosteric Ligandta1_on
5.00Single3P0GBI1671073P0G-β2-BI167107
5.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
5.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
5.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
5.00Single4DJHJDTic4DJH-κ-JDTic
5.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
5.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
5.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
5.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
5.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
5.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
5.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
5.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
5.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
5.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
5.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
5.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
5.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
5.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
5.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
5.00Single7P2L4YI7P2L-mGlu5-4YI
5.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
5.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
5.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
5.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
5.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
5.00Single8E0GBU728E0G-μ-BU72
5.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
5.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
5.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
5.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.00Single8XVLZibotentan8XVL-ETA-Zibotentan
5.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
5.00Single8ZWFJR14a8ZWF-C3aB-JR14a
5.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
5.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
5.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
5.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
5.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
5.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
5.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
5.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
5.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
4.76Single3D4STimolol3D4S-β2-Timolol
4.76Single4LDEBI1671074LDE-β2-BI167107
4.76Single6A93Risperidone6A93-5-HT2A-Risperidone
4.76Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
4.76Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.76Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.76Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.76Single7DFPSpiperone7DFP-D2-Spiperone
4.76Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.76Single7K15MKD0467K15-BLT1-MKD046-Na
4.76Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
4.76Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
4.76Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.76Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.76Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
4.76Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
4.76Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.76Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.76Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
4.76Single8JJ8Formoterol8JJ8-β2-Formoterol
4.76Single9BJKNAM9BJK-μ-Naloxone-NAM
4.76Consensusalpha1_offOrthosteric Ligandalpha1a_off
4.76Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
4.76Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
4.76Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
4.76Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
4.76Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
4.76Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.76Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
4.76Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.76Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
4.76Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
4.76Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.76Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.76Consensusorexin_onOrthosteric Ligandox2_on
4.76Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
4.76Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
4.55Single5X93K-87945X93-ETB-K-8794
4.55Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
4.55Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
4.55Single6H7LDobutamine6H7L-β1-Dobutamine
4.55Single6K1QIRL25006K1Q-ETB-IRL2500
4.55Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
4.55Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
4.55Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
4.55Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
4.55Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
4.55Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.55Single8XVJMacitentan8XVJ-ETA-Macitentan
4.55Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
4.55Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
4.55Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.55Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.55Consensusendothelin_offOrthosteric Ligandetb_off
4.55Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
4.55Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.55Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
4.35Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
4.35Single7SK9CCX6627SK9-ACKR3-CCX662
4.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
4.35Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
4.35Single8X5YAstemizole8X5Y-H1-Astemizole
4.35Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
4.35Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
4.17Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
4.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
4.17Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
4.17Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.17Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
4.17Consensussomatostatin_offOrthosteric Ligandsst2_off
4.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
4.00Single7SK5CXCL127SK5-ACKR3-CXCL12
4.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
4.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.85Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
3.85Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
3.85Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
3.70Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.70Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
3.45Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
3.45Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
3.45Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
3.33Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
3.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
3.12Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
2.50Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3

Consensus Members
Id Members
adgrg2_on_gp 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7WUQ-ADGRG2-Gs/β1/γ2
7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
adgrg4_on_gp 7WUJ-ADGRG4-chim(NtGi1-Gs)/β1/γ2
Net Summary
Imin 4.26333
Number of Linked Nodes 868
Number of Links 1012
Number of Hubs 154
Number of Links mediated by Hubs 612
Number of Communities 16
Number of Nodes involved in Communities 189
Number of Links involved in Communities 279
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 2304456
Length Of Smallest Path 3
Average Path Length 30.6184
Length of Longest Path 70
Minimum Path Strength 0.441667
Average Path Strength 8.41445
Maximum Path Strength 26.3558
Minimum Path Correlation 0.701667
Average Path Correlation 0.981166
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 41.221
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1008
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
class-b2_on_gpadgrg_on_gp
adgrf_on_gp
adgrl_on_gp
adgre_on_gp
adgrd_on_gp



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