Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 3.155402
2G.S1.02 5.76464455
3G.H1.01 5.1525459
4G.S2.05 5.10643403
5G.S2.08 7.21754205
6G.S3.03 8.05571457
7G.S3.04 7.99929426
8G.S3.05 3.43143557
9G.S3.06 7.34429625
10G.S3.07 3.79786459
11G.s3h2.03 4.33571429
12G.H2.04 3.63143429
13G.H2.06 4.96286529
14G.H2.07 4.36408729
15G.h2s4.01 5.186529
16G.s4h3.04 6.84878738
17G.s4h3.05 9.76857439
18G.H3.01 6.57571439
19G.H3.09 5.13095639
20G.H3.17 7.65571595
21G.H3.18 5.2499
22G.S5.03 3.52343558
23G.S5.04 3.11571439
24G.S5.05 3.53214659
25G.S5.07 3.61036459
26G.HG.04 6.22886539
27G.HG.07 4.63914539
28G.hgh4.01 4.47714406
29G.hgh4.02 6.785956117
30G.hgh4.05 7.844644117
31G.H4.03 5.925634
32G.H4.05 4.111434114
33G.H4.10 9.592144116
34G.H4.12 7.01607435
35G.H4.15 4.69143538
36G.h4s6.02 5.090364158
37G.h4s6.11 4.998214157
38G.S6.02 5.0558167
39G.S6.05 4.58643434
40G.s6h5.01 4.85643459
41G.s6h5.02 2.35679437
42G.H5.03 5.02457558
43G.H5.08 5.838575208
44G.H5.13 5.72254168
45G.H5.17 4.589644225
46G.H5.20 3.54357409
47G.H5.25 4.75254107
48b.1x1 2.87229504
49b.h2x5 3.72143405
50b.lhb1x3 2.94786402
51b.lhb1x6 3.252864143
52b.lhb1x11 3.45286404
53b.b1x3 5.35643467
54b.b1x6 5.68857569
55b.l1x3 7.4231669
56b.b2x1 7.94829598
57b.b2x5 6.92657507
58b.b3x3 3.770364188
59b.l3x2 4.02543569
60b.b4x3 3.466865187
61b.b4x6 8.99071669
62b.b5x2 5.64393407
63b.b5x3 5.76952669
64b.b5x5 3.94679405
65b.b5x7 5.7475407
66b.l5x1 3.820295188
67b.l5x5 7.13357629
68b.b6x5 4.07893406
69b.l6x5 5.710714214
70b.b7x1 5.825435214
71b.l7x2 3.35786429
72b.b8x4 5.2745186
73b.l8x5 3.073435243
74b.l9x3 6.95405689
75b.l9x6 4.11079928
76b.b10x5 3.85381689
77b.l10x1 3.12214403
78b.b11x4 5.16543589
79b.l11x2 6.15686589
80b.b12x6 8.02788
81b.b12x7 5.218214259
82b.b13x7 7.14577
83b.l13x3 7.57857679
84b.l13x6 3.79964429
85b.b14x3 3.69964475
86b.b15x1 6.86107479
87b.b15x2 6.18393446
88b.l15x2 4.14629579
89b.b16x4 9.92476
90b.b16x5 4.09971545
91b.b16x6 8.45809678
92b.b17x4 5.00286445
93b.b17x5 5.735447
94b.b17x7 6.98429448
95b.l17x3 7.10551749
96b.l17x6 5.68971529
97b.b18x3 4.46607448
98b.l18x1 6.412657196
99b.l18x2 5.815364197
100b.b19x2 5.83333646
101b.b19x4 6.35071448
102b.l19x2 5.93143449
103b.b20x4 8.86343548
104b.b20x6 5.68167646
105b.b20x7 4.0925409
106b.l20x2 6.94643409
107b.b21x1 7.75571547
108b.b21x2 4.57321406
109b.b21x5 5.492144124
110b.b21x7 5.049296125
111b.l21x7 3.993574125
112b.b22x5 5.10696197
113b.l22x5 5.687435149
114b.b23x6 6.429187127
115b.l23x1 7.575406
116b.l24x3 5.12429405
117b.b25x7 5.70036407
118b.l25x3 7.973145179
119b.l27x1 9.14405699
120b.l27x2 7.136074179
121b.b28x4 6.438214176
122b.b28x6 7.044575179
123b.b28x7 4.88571569
124g.h1x1 2.59943502
125g.h1x5 2.07914506
126g.h1x10 3.14214479
127g.h1x11 2.57086579
128g.l1x2 3.82643442
129g.l1x4 6.87536448
130g.h2x11 7.796434196
131g.ctx3 6.377866149
132g.ctx6 4.139435146
133g.ctx16 4.62482868
134Lig 6.752761510
135NT.H28 3.5851718
136NT.Y29 5.02653717
1371x39 4.49238616
1381x40 2.17821403
1391x50 4.413435109
140I1x50 9.099145138
1412x39 4.31393408
1422x40 10.26745139
1432x42 5.698508
1442x46 4.023435109
1452x47 2.20607409
1462x50 5.095246109
1472x57 5.78776716
1482x61 5.25643415
149E1x501 2.74886515
1503x25 6.63735719
1513x26 5.592516
1523x28 5.70476616
1533x29 7.842515
1543x33 8.14415
1553x44 4.28429407
1563x46 4.424294108
1573x49 6.55286409
1583x50 5.564766109
1593x51 5.25643408
1604x42 4.83393407
1614x60 7.07321415
162E2.W182 4.20393415
163E2.L195 4.79857513
164E2.Y198 4.66232814
1655x39 6.40429617
1665x48 1.49143404
1675x58 4.21214409
1685x62 6.21821406
1696x28 0.915405
1706x33 3.72286408
1716x44 4.69429419
1726x48 6.28718
1736x52 4.74571406
1746x58 4.008576274
1756x59 3.8075404
1767x31 4.37254273
1777x45 6.78571419
1787x53 4.368214109
1798x50 6.456434138
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b28x5 g.ctx16 18.26354.84571NoYes658
2b.b1x6 b.b28x5 17.67732.85571YesNo695
3b.b1x6 b.b4x6 14.955212.5271YesYes699
4b.b28x7 g.ctx16 28.15715.86857YesYes698
5b.b28x7 b.lhb1x11 36.19222.80429YesYes094
6b.b25x7 b.lhb1x11 32.23014.24YesYes074
7b.b25x7 b.b28x6 46.419311.7114YesYes079
8b.b27x3 b.b28x6 27.57858.83714NoYes089
9b.b26x3 b.b27x3 68.10293.79143NoNo068
10b.b22x2 b.b26x3 67.76465.14857NoNo086
11b.b22x1 b.b22x2 67.71113.2NoNo088
12b.b22x1 b.l23x1 67.6722.68714NoYes086
13b.l23x1 b.l25x6 51.250617.5243YesNo068
14b.l25x6 b.l27x1 32.212217.1343NoYes089
15b.b2x1 b.l27x1 31.11885.65YesYes989
16b.b2x1 b.l3x1 31.220813.6857YesNo089
17b.l3x1 b.l5x5 31.15115.16429NoYes099
18b.b27x3 b.l25x3 80.11487.62714NoYes089
19b.l25x3 b.l27x2 99.77024.86YesYes1799
20b.l25x4 b.l27x2 1005.13NoYes059
21I1x48 b.l25x4 99.9768.29571NoNo065
22I1x48 I1x51 99.95774.67857NoNo067
232x41 I1x51 99.93654.66857NoNo047
242x41 4x42 99.91584.69NoYes047
252x42 4x42 63.13626.78714YesYes087
262x42 3x46 59.34492.87286YesYes088
273x46 3x50 24.03534.83286YesYes1089
283x50 G.H5.25 33.39898.15571YesYes1097
29G.H5.20 G.H5.25 30.53142.96571YesYes097
30b.b28x4 b.b28x6 20.21715.8YesYes1769
31b.b28x4 b.l25x3 20.47837.29857YesYes1769
326x29 G.H5.20 23.55162.82NoYes069
336x29 G.H5.13 22.80997.11286NoYes068
34G.H5.13 G.S6.02 21.66948.04571YesYes1687
35G.H5.10 G.S6.02 21.33274.00286NoYes067
36G.H5.10 G.S5.03 21.17863.25NoYes068
37G.S4.03 G.S5.03 15.26374.83857NoYes578
38G.S1.04 G.S4.03 15.71064.07571NoNo077
39G.S1.04 G.S3.05 15.62343.63571NoYes077
40G.H2.04 G.H2.07 11.43914.42857YesYes299
41b.l5x5 b.l7x2 27.96153.74143YesYes299
42G.H1.08 G.S3.05 13.413.09286NoYes587
43G.H1.08 G.H5.04 13.43143.04143NoNo087
44G.H3.17 b.l25x6 19.21173.57143YesNo058
45G.H3.15 G.H3.17 18.80967.91NoYes985
46G.H3.15 G.H3.18 18.65933.45143NoYes989
47G.H3.18 G.S4.02 17.98968.25286YesNo998
48G.S4.02 G.S5.02 18.03473.36429NoNo086
49G.H3.09 G.S5.02 16.56093.40714YesNo096
50G.H4.03 G.HG.01 14.64124.77714YesNo345
51G.HG.01 G.s6h5.02 14.53092.76857NoYes357
52G.H5.02 G.s6h5.02 14.7242.77143NoYes047
53G.H5.02 I3.R238 14.78343.53571NoNo040
54G.H5.09 I3.R238 14.81952.89143NoNo040
55G.H5.05 G.H5.09 14.74739.13714NoNo054
56G.H5.05 G.S2.08 12.58654.01571NoYes2055
57b.l7x2 b.l9x6 25.93693.01429YesYes298
58G.H2.04 G.H3.08 10.33692.95YesNo299
59G.H3.08 G.S4.04 10.28313.83NoNo099
60G.H3.09 G.S4.04 10.436113.0157YesNo099
61g.ctx3 g.ctx6 12.35528.53YesYes1496
62b.l22x5 g.ctx6 26.32384.33857YesYes1496
63b.l22x5 b.lhb1x3 13.47253.57857YesYes092
64b.h2x5 b.lhb1x3 12.23272.82286YesYes052
65b.h2x1 b.h2x5 22.2744.63286NoYes055
66b.b21x5 b.h2x1 18.97636.05857YesNo045
67b.b21x5 b.b21x7 19.53068.72571YesYes1245
68b.b20x5 b.b21x7 36.61374.85429NoYes075
69b.b20x5 b.b21x4 36.38313.75571NoNo075
70b.b20x7 b.b21x4 36.15716.01143YesNo095
71b.b20x7 b.l20x2 35.48623.74143YesYes099
72b.l20x2 g.l1x5 35.2415.37143YesNo094
73g.l1x3 g.l1x5 35.0240.6NoNo014
74g.l1x2 g.l1x3 34.80690.6YesNo021
75b.b21x1 g.l1x2 16.14733.2YesYes472
76b.1x19 b.b21x1 10.57169.01857NoYes067
77b.l22x5 b.l24x2 11.92516.42YesNo096
78b.h2x5 b.l24x2 11.53574.63286YesNo056
79b.l11x1 b.l9x6 32.98444.76143NoYes098
80b.b11x6 b.l11x1 32.82732.65286NoNo099
81b.b11x6 b.l9x3 31.410814.9443NoYes899
82b.b11x4 b.l9x3 24.46435.87143YesYes899
83b.b10x3 b.b11x4 25.46083.13857NoYes889
84b.b10x3 b.b6x2 25.43565.31143NoNo088
85b.b10x2 b.b6x2 24.9443.38NoNo068
86b.b10x2 b.b10x4 14.21995.37143NoNo066
87b.b10x4 b.b2x4 13.971410.9629NoNo066
88b.b2x4 b.b6x5 13.72383.11429NoYes066
89b.b3x3 b.b6x5 12.97514.50714YesYes086
90b.b3x3 b.b4x3 10.14013.61857YesYes1887
91b.b10x2 b.b14x3 15.60894.53286NoYes065
92b.b17x5 g.l1x2 16.92754.70571YesYes472
93b.b16x5 b.b17x5 11.57543.04YesYes457
94b.b14x3 b.b15x1 12.63842.78286YesYes759
95b.l21x7 b.l23x1 32.55465.77857YesYes056
96b.b23x6 b.l21x7 31.35543.07143YesYes1275
97b.b21x7 b.b24x6 29.7014.82286YesNo1258
98b.b24x5 b.b25x7 13.4992.76714NoYes057
992x46 3x46 59.60163.25857YesYes1098
1002x46 3x43 62.01793.36YesNo099
1013x43 6x44 61.11783.65429NoYes099
1026x44 6x48 60.03118.01714YesYes198
1036x48 Lig 56.45355.19571YesYes180
1044x42 4x46 36.36743.87143YesNo077
1052x45 4x46 36.23246.06857NoNo097
1062x45 4x50 36.53697.10286NoNo099
1073x38 4x50 35.9544.26NoNo079
1083x38 4x53 35.56843.42NoNo078
1093x37 4x53 35.01083.26NoNo068
1103x37 Lig 34.97385.04429NoYes060
111Lig NT.Y29 14.74983.16286YesYes107
1123x29 Lig 12.50058.36714YesYes150
1133x32 Lig 11.35254.12143NoYes160
1143x33 Lig 11.784321.7043YesYes150
1157x38 Lig 11.35519.01857NoYes050
116E2.L195 Lig 18.8595.89714YesYes130
1172x57 3x32 11.01394.61714YesNo166
1182x57 7x38 10.92034.68857YesNo065
1191x39 2x57 11.40663.39YesYes166
1203x26 E2.Y198 10.15763.24286YesYes164
1213x25 3x26 10.14712.72YesYes196
1223x26 E2.N183 10.14259.14857YesNo065
1236x58 7x31 10.28915.42714YesYes2743
124b.b23x1 g.ctx6 17.09173.16143NoYes056
125b.b23x6 b.b24x6 29.50676.89YesNo1278
126G.H5.04 G.S2.08 13.34919.36571NoYes075
127b.b23x1 b.b24x5 12.97444.47NoNo055
1283x50 7x53 12.88666.17143YesYes1099
1292x46 7x53 12.97683.01286YesYes1099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
LigNT.Y293.162861YesYes0001
LigNT.K343.317141YesNo0001
2x60Lig6.041431NoYes5010
2x64Lig3.798570NoYes4010
3x29Lig8.367141YesYes5010
3x32Lig4.121431NoYes6010
3x33Lig21.70431YesYes5010
3x36Lig8.202861NoYes6010
3x37Lig5.044290NoYes6010
5x47Lig6.105711NoYes7010
6x48Lig5.195711YesYes8010
6x51Lig6.062860NoYes6010
6x55Lig5.251430NoYes6010
7x38Lig9.018570NoYes5010
NT.K34NT.Y295.972861NoYes0011
E1x50NT.Y292.855711NoYes5021
E1x501NT.Y294.395711YesYes5021
3x25NT.Y294.682861YesYes9021
E2.P196NT.Y2911.52290NoYes0021
2x573x324.617141YesNo6621
2x577x384.688571YesNo6521
2x603x2810.50431NoYes5612
2x603x326.211431NoNo5611
E1x50E1x5015.174291NoYes5522
3x28E1x504.618571YesNo6522
3x253x286.857141YesYes9622
3x253x2915.57711YesYes9521
3x25E2.L1953.092861YesYes9021
3x25E2.Y1983.444291YesYes9022
3x283x295.485711YesYes6521
3x29E2.L1954.168571YesYes5011
3x29E2.Y1985.611431YesYes5012
3x33E2.Y1982.947141YesYes5012
3x335x394.717141YesYes5712
3x335x433.191431YesNo5612
3x366x485.042861NoYes6811
3x374x533.260NoNo6812
3x406x484.027140NoYes7821
E2.L195E2.V1944.471YesNo0012
E2.L195E2.Y1986.364281YesYes0012
5x39E2.Y1984.112861YesYes7022
5x395x437.681YesNo7622
5x406x554.280NoNo6621
5x446x523.705710NoYes5622
5x446x552.947140NoNo5621
5x476x4811.45431NoYes7811
5x476x526.735711NoYes7612
6x446x488.017141YesYes9821
6x447x453.452861YesYes9922
6x487x458.555711YesYes8912
E2.L195Lig5.897141YesYes0010
NT.I25NT.Y292.592860NoYes0021
2x64E1x472.122860NoNo4412
6x487x411.667141YesNo8712

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
93.33Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
87.50Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
87.50Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
80.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
78.57Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
77.78Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
75.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
73.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
70.59Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
70.59Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
68.75Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
66.67Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
66.67Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
64.71Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
64.71Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
64.71Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
64.29Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
63.16Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
62.50Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
58.82Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
58.82Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
58.82Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
58.82Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
57.89Single5ZTYAM102575ZTY-CB2-AM10257
57.89Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
56.25Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
56.25Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
55.56Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
55.56Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
55.56Consensuslpl_offOrthosteric Ligands1p_off lpa_off
55.56Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
55.56Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
55.56Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
55.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
55.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
55.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
55.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
53.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
53.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
52.94Single7C4SS1P7C4S-S1P3-S1P
52.63Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
52.63Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
52.63Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
52.63Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
52.38Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
50.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
50.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
50.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
50.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
50.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
47.83Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
47.37Single6ZG4HTL00099366ZG4-M1-HTL0009936
47.37Single7DFPSpiperone7DFP-D2-Spiperone
47.37Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
47.37Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
47.37Single7YITNalfurafine7YIT-κ-Nalfurafine
47.37Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
47.37Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
47.37Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
47.37Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
47.37Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
47.37Consensuslpa_offOrthosteric Ligandlpa1_off
47.06Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
47.06Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
47.06Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
47.06Single9CHXS-Carazolol9CHX-β2-S-Carazolol
47.06Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
47.06Consensusalpha2_onOrthosteric Ligandalpha2b_on
47.06Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
47.06Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
46.67Single7SRQLSD7SRQ-5-HT2B-LSD
46.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
46.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
45.83Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
45.00Single5X93K-87945X93-ETB-K-8794
45.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
45.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
45.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
45.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
45.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
45.00Consensusendothelin_offOrthosteric Ligandetb_off
45.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
45.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
45.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
44.44Single5C1MBU725C1M-μ-BU72
44.44Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
44.44Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
44.44Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
44.44Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
44.44Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
44.44Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
44.44Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
44.44Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
44.44Single8TF5Oleic acid8TF5-GPR6-Oleic acid
44.44Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
44.44Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
44.44Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
44.44Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
44.44Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
44.44Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
44.44Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
44.44Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
44.44Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
44.44Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
44.44Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
44.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
43.75Single6AKXA4R6AKX-CCR5-A4R
43.75Single6B73MP11046B73-κ-MP1104
43.75Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
43.75Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
43.75Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
43.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
43.75Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
43.75Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
43.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
43.75Single8Y0HVUF114188Y0H-CXCR3-VUF11418
43.75Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
43.75Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
43.75Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
43.75Consensusorexin_offOrthosteric Ligandox2_off ox1_off
43.75Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
43.48Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
43.48Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
43.48Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.86Single4UG2CGS216804UG2-A2A-CGS21680
42.86Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
42.86Single7SK9CCX6627SK9-ACKR3-CCX662
42.86Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
42.86Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.86Single8QJ2pN1628QJ2-MC4-pN162-Gs
42.86Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
42.86Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
42.86Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
42.31Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
42.31Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
42.31Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
42.11Single2YDVNECA2YDV-A2A-NECA
42.11Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
42.11Single4DJHJDTic4DJH-κ-JDTic
42.11Single4UHRCGS216804UHR-A2A-CGS21680
42.11Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
42.11Single5G53NECA5G53-A2A-NECA-Gs
42.11Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
42.11Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
42.11Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
42.11Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
42.11Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
42.11Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
42.11Single7FEECP559407FEE-CB1-CP55940-ZCZ011
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
42.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
42.11Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
42.11Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
42.11Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
42.11Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
42.11Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
42.11Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
42.11Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
42.11Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
42.11Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
42.11Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
42.11Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
42.11Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
42.11Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
42.11Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
42.11Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
42.11Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
41.67Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
41.18Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
41.18Single2YDOAdenosine2YDO-A2A-Adenosine
41.18Single3RZECidoxepin3RZE-H1-Cidoxepin
41.18Single4MBSMaraviroc4MBS-CCR5-Maraviroc
41.18Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
41.18Single4ZJCSB-6740424ZJC-OX1-SB-674042
41.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
41.18Single6TPGEMPA6TPG-OX2-EMPA
41.18Single6TPNHTL66416TPN-OX2-HTL6641
41.18Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
41.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
41.18Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
41.18Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
41.18Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
41.18Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
41.18Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
41.18Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
41.18Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
41.18Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
41.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
41.18Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
41.18Single8K5CAcipimox8K5C-HCA2-Acipimox
41.18Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
41.18Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
41.18Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
41.18Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
41.18Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
41.18Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
41.18Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
41.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
41.18Consensusalpha1_onOrthosteric Ligandalpha1a_on
41.18Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
41.18Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
41.18Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
41.18Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
41.18Consensushca_onOrthosteric Ligandhca2_on
41.18Consensusopsins_offOrthosteric Ligandrhodopsin_off
41.18Consensussensory_offOrthosteric Ligandopsins_off
40.91Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
40.91Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.91Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
40.91Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.91Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
40.91Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.91Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.91Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.91Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.91Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
40.00Single3D4STimolol3D4S-β2-Timolol
40.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
40.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
40.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
40.00Single6KQICP559406KQI-CB1-CP55940-Org27569
40.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
40.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
40.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
40.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
40.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
40.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
40.00Single8JWY2-1188JWY-A2A-2-118
40.00Single8JWZAB9288JWZ-A2A-AB928-Na
40.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
40.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
40.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
40.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
40.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
40.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
40.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
40.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
40.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
40.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
40.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
40.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
40.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
40.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
40.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
40.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
40.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
40.00Consensusorexin_onOrthosteric Ligandox2_on
39.29Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.29Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.29Consensusbombesin_onOrthosteric Ligandbb2_on
39.29Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
39.29Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
39.13Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
39.13Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
38.89Single3NY8ICI118-5513NY8-β2-ICI118-551
38.89Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.89Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
38.89Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
38.89Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.89Single4GBRS-Carazolol4GBR-β2-S-Carazolol
38.89Single4MQSIperoxo4MQS-M2-Iperoxo
38.89Single4U14Tiotropium4U14-M3-Tiotropium
38.89Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
38.89Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
38.89Single5TGZAM65385TGZ-CB1-AM6538
38.89Single6DRXLisuride6DRX-5-HT2B-Lisuride
38.89Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
38.89Single6TOTLemborexant6TOT-OX1-Lemborexant
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
38.89Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
38.89Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
38.89Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
38.89Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
38.89Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
38.89Single7V3ZCP559407V3Z-CB1-CP55940
38.89Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
38.89Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
38.89Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.89Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
38.89Single8JJOAlprenolol8JJO-β2-Alprenolol
38.89Single8RLNLUF58348RLN-A2A-LUF5834
38.89Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
38.89Single8T1WCVN4248T1W-GPR6-CVN424
38.89Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
38.89Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
38.89Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.89Single8X63Mepyramine8X63-H1-Mepyramine
38.89Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
38.89Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
38.89Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
38.89Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
38.89Consensus5ht5_onOrthosteric Ligand5ht5a_on
38.89Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
38.89Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
38.89Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.89Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusblt_onOrthosteric Ligandblt1_on
38.89Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
38.89Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Consensusdopamine_offOrthosteric Ligandd2_off d3_off
38.89Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.89Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
38.89Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
38.89Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
38.89Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
38.89Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.89Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
38.89Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
38.89Consensushca_on_gpOrthosteric Ligandhca2_on_gp
38.89Consensushistamine_offOrthosteric Ligandh1_off
38.89Consensusleukotriene_onOrthosteric Ligandblt_on
38.89Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
38.89Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
38.89Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
38.46Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
38.10Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
38.10Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
38.10Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.10Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
38.10Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
38.10Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
38.10Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
38.10Single7UM4AS26747237UM4-5-HT5A-AS2674723
38.10Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
38.10Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
38.10Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
38.10Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
38.10Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
38.10Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.10Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
38.10Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
38.10Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
38.10Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
38.10Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.10Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
38.10Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
37.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
37.50Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
37.50Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
37.50Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
37.50Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
37.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
37.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
37.50Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
37.50Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
37.50Single8K5BNiacin8K5B-HCA2-Niacin
37.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
37.50Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
37.50Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
37.50Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
37.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
37.50Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
37.50Consensusangiotensin_onOrthosteric Ligandat1_on
37.50Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.50Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
37.50Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
37.50Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
37.04Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
37.04Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
36.84Single2RH1S-Carazolol2RH1-β2-S-Carazolol
36.84Single2YCWS-Carazolol2YCW-β1-S-Carazolol
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
36.84Single5D6LS-Carazolol5D6L-β2-S-Carazolol
36.84Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
36.84Single5WQCEMPA5WQC-OX2-EMPA
36.84Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
36.84Single5XPRBosentan5XPR-ETB-Bosentan
36.84Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
36.84Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.84Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
36.84Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
36.84Single6PS6Timolol6PS6-β2-Timolol
36.84Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
36.84Single6TP6Filorexant6TP6-OX1-Filorexant
36.84Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.84Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
36.84Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
36.84Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
36.84Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
36.84Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
36.84Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
36.84Single7W41PD1762527W41-BB2-PD176252
36.84Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
36.84Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
36.84Single8JXSPF-61428JXS-D1-PF-6142
36.84Single8S4DCMF-0198S4D-Apelin-CMF-019
36.84Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
36.84Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
36.84Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
36.84Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
36.84Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
36.84Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
36.84Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
36.84Consensusa3_on_gpOrthosteric Liganda3a_on_gp
36.84Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
36.84Consensusamine_offonOrthosteric Ligandamine_off amine_on
36.84Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
36.84Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
36.84Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
36.84Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
36.84Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.84Consensusbombesin_offOrthosteric Ligandbb2_off
36.84Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.84Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
36.84Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
36.84Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
36.84Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
36.84Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Consensustrace-amine_onOrthosteric Ligandta1_on
36.36Single3NY9ICI118-5513NY9-β2-ICI118-551
36.36Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.36Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.36Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
36.36Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
36.36Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
36.36Single8X5YAstemizole8X5Y-H1-Astemizole
36.36Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
36.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
36.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
36.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
36.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
36.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
35.71Single6IGLIRL16206IGL-ETB-IRL1620
35.29Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
35.29Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
35.29Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
35.29Single4S0VSuvorexant4S0V-OX2-Suvorexant
35.29Single5WS3EMPA5WS3-OX2-EMPA
35.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.29Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
35.29Single6TODEMPA6TOD-OX1-EMPA-Na
35.29Single6TPJSuvorexant6TPJ-OX2-Suvorexant
35.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.29Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
35.29Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
35.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
35.29Single7XRRLemborexant7XRR-OX2-Lemborexant
35.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
35.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
35.29Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
35.29Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
35.29Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
35.29Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
35.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
35.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
35.29Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.29Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
35.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
35.29Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
35.29Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
35.29Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
35.29Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
35.29Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
35.29Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Consensusalpha2_offOrthosteric Ligandalpha2c_off
35.29Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
35.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
35.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.29Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
35.29Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
35.29Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
35.29Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
35.29Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
35.00Single4U15Tiotropium4U15-M3-Tiotropium
35.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
35.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
35.00Single5XR8AM8415XR8-CB1-AM841
35.00Single5XRAAM115425XRA-CB1-AM11542
35.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
35.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.00Single6E59L-7607356E59-NK1-L-760735
35.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
35.00Single6J20Aprepitant6J20-NK1-Aprepitant
35.00Single6J21Aprepitant6J21-NK1-Aprepitant
35.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
35.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
35.00Single6OL9Tiotropium6OL9-M5-Tiotropium
35.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
35.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
35.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
35.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
35.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
35.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8EA0Iperoxo8EA0-M3-Iperoxo
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
35.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
35.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
35.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
35.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
35.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
35.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
35.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
35.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
35.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
35.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
35.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Single8XVLZibotentan8XVL-ETA-Zibotentan
35.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
35.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
35.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
35.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
35.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
35.00Consensusa2_onOrthosteric Liganda2b_on
35.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
35.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
35.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
35.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
35.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
35.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
35.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single4XT1Fractalkine4XT1-US28-Fractalkine
34.78Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
34.78Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
34.78Single8IEBA1LYA8IEB-GPR156-A1LYA
34.78Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
34.78Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
34.78Single8WDTphotoNECA8WDT-A2A-photoNECA
34.78Single8WKYPG-9348WKY-MC4-PG-934
34.78Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.78Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
34.78Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
34.62Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
34.62Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
34.62Single8ZRTET-18ZRT-ETB-ET-1
34.48Single5GLHEndothelin-15GLH-ETB-Endothelin-1
34.48Single6IGKEndothelin-36IGK-ETB-Endothelin-3
33.33Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
33.33Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
33.33Single4LDEBI1671074LDE-β2-BI167107
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single5CXVTiotropium5CXV-M1-Tiotropium
33.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
33.33Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6TP3Nemorexant6TP3-OX1-Nemorexant
33.33Single6TPKRetosiban6TPK-OT-Retosiban
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
33.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
33.33Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
33.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7K15MKD0467K15-BLT1-MKD046-Na
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
33.33Single7UL3Famotidine7UL3-H2-Famotidine
33.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
33.33Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
33.33Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
33.33Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
33.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
33.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
33.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
33.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
33.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
33.33Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
33.33Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
33.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
33.33Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
33.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
33.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
33.33Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
33.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
33.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
33.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
33.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
33.33Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
33.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
33.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
33.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
33.33Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
33.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
33.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
33.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
33.33Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
33.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensusvasop-oxy_offOrthosteric Ligandot_off
32.26Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
32.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
32.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
32.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
32.00Single6PT2KGCHM076PT2-δ-KGCHM07
32.00Single6W25SHU91196W25-MC4-SHU9119-Ca
32.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
32.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
32.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
32.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
32.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
31.82Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
31.82Single6K1QIRL25006K1Q-ETB-IRL2500
31.82Single7EZCUKA7EZC-A2A-UKA
31.82Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
31.82Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
31.82Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
31.82Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.58Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
31.58Single2Y04Salbutamol2Y04-β1-Salbutamol
31.58Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.58Single4DAJTiotropium4DAJ-M3-Tiotropium
31.58Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
31.58Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
31.58Single4YAYZD-71554YAY-AT1-ZD-7155
31.58Single5DHGC-355DHG-NOP-C-35
31.58Single5DHHSB-6121115DHH-NOP-SB-612111
31.58Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
31.58Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
31.58Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
31.58Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
31.58Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
31.58Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
31.58Single6PS1Timolol6PS1-β2-Timolol
31.58Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
31.58Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
31.58Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.58Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.58Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
31.58Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.58Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
31.58Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
31.58Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
31.58Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.58Single7WC7Lisuride7WC7-5-HT2A-Lisuride
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
31.58Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
31.58Single8CU6LJ-45178CU6-A2A-LJ-4517
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
31.58Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
31.58Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.58Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.58Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.58Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.58Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.58Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.58Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.58Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.58Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
31.58Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Single8JXRLSD8JXR-D1-LSD
31.58Single8K5DGSK2560738K5D-HCA2-GSK256073
31.58Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
31.58Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
31.58Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
31.58Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
31.58Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
31.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
31.58Single8X64Desloratadine8X64-H1-Desloratadine
31.58Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
31.58Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.58Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
31.58Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensusa3_onOrthosteric Liganda3a_on
31.58Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.58Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.58Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.58Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.58Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
31.25Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
31.25Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
31.25Single3OE6IT1t3OE6-CXCR4-IT1t
31.25Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
31.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
31.25Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
31.25Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
31.25Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
31.25Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
31.25Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
31.25Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
31.25Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
31.25Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
31.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
31.25Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
31.25Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.25Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.25Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
31.25Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
31.03Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
31.03Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
31.03Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
31.03Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
30.77Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
30.77Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.77Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
30.77Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.77Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
30.77Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.77Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.77Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.77Consensusvasop-oxy_onOrthosteric Ligandv2_on
30.77Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
30.43Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
30.43Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.43Single6PT3DPI-2876PT3-δ-DPI-287
30.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.43Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.43Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.43Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
30.43Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
30.43Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
30.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.00Single5TVNLSD5TVN-5-HT2B-LSD
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
30.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
30.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
30.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
30.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
30.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
30.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
30.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
30.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
30.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7WC6LSD7WC6-5-HT2A-LSD
30.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
30.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
30.00Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
30.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
30.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
30.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
30.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
30.00Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
30.00Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
30.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
30.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
30.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
30.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
30.00Consensusblt_offOrthosteric Ligandblt1_off
30.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
30.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
29.63Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
29.63Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.63Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
29.63Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.63Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
29.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Single3OE9IT1t3OE9-CXCR4-IT1t
29.41Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
29.41Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
29.41Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
29.41Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
29.41Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
29.41Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
29.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
29.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
29.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
29.41Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
29.41Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
29.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
29.41Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
29.41Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
29.41Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
29.41Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
29.41Single9B9Y7DY9B9Y-CB1-7DY
29.41Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
29.41Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
29.41Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
29.41Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
29.41Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.41Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
29.17Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
29.17Single4IARErgotamine4IAR-5-HT1B-Ergotamine
29.17Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
29.17Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.17Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
29.17Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
29.17Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
29.17Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
29.17Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
29.17Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
29.17Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
29.03Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
28.57Single3P0GBI1671073P0G-β2-BI167107
28.57Single4XT3Fractalkine4XT3-US28-Fractalkine
28.57Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.57Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
28.57Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
28.57Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
28.57Single6WGTLSD6WGT-5-HT2A-LSD
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
28.57Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
28.57Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
28.57Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.57Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
28.57Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
28.57Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
28.57Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
28.57Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
28.57Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
28.57Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
28.57Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
28.57Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
28.57Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
28.57Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
28.57Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
28.57Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
28.57Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
28.57Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.57Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
28.57Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.57Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
28.57Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.57Consensuslpa_onOrthosteric Ligandlpa1_on
28.57Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
28.57Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
28.57Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
28.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.12Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.00Single6HLOAprepitant6HLO-NK1-Aprepitant
28.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
28.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
28.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
28.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
27.78Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.78Single3ODUIT1t3ODU-CXCR4-IT1t
27.78Single3PWHZM-2413853PWH-A2A-ZM-241385
27.78Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.78Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
27.78Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.78Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
27.78Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.78Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
27.78Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
27.78Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.78Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
27.78Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
27.78Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
27.78Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
27.78Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.78Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
27.78Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
27.78Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
27.78Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
27.78Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
27.78Single8IWESpermidine8IWE-TA9-Spermidine
27.78Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
27.78Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
27.78Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
27.78Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.78Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.78Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.78Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.78Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
27.78Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
27.78Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.78Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
27.59Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
27.59Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
27.59Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.59Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
27.27Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.27Single4N4WSANT-14N4W-SMO-SANT-1
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single5X33BIIL2605X33-BLT1-BIIL260
27.27Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
27.27Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
27.27Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
27.27Single6MXTSalmeterol6MXT-β2-Salmeterol
27.27Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
27.27Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.27Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
27.27Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
27.27Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
27.27Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
27.27Single8JJ8Formoterol8JJ8-β2-Formoterol
27.27Single8JJLOlodaterol8JJL-β2-Olodaterol
27.27Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
27.27Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
27.27Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
27.27Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
27.27Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.92Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
26.92Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
26.92Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
26.92Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.92Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
26.67Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
26.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
26.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
26.67Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
26.67Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.67Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.67Consensusbradykinin_onOrthosteric Ligandbk2_on
26.67Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
26.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.32Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.32Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.32Single5JTBZM-2413855JTB-A2A-ZM-241385
26.32Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.32Single6A94Zotepine6A94-5-HT2A-Zotepine
26.32Single6AQFZM-2413856AQF-A2A-ZM-241385
26.32Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6VI4JDTic6VI4-κ-JDTic
26.32Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
26.32Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
26.32Single7T32ZM-2413857T32-A2A-ZM-241385
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.32Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
26.32Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
26.32Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
26.32Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
26.32Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
26.32Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.32Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.32Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.32Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
26.32Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.32Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
26.32Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
26.32Single9BJKNaloxone9BJK-μ-Naloxone-NAM
26.32Consensusa2_offOrthosteric Liganda2a_off
26.32Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
26.32Consensusgrh_offOrthosteric Ligandgnrh1_off
26.32Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
26.32Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.09Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
26.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.09Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.09Single6H7LDobutamine6H7L-β1-Dobutamine
26.09Single6IBLArformoterol6IBL-β1-Arformoterol
26.09Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
26.09Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
26.09Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
26.09Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
26.09Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
26.09Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8XVJMacitentan8XVJ-ETA-Macitentan
26.09Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
26.09Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
26.09Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.09Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.93Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.93Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
25.93Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
25.93Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.93Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.93Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
25.93Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
25.93Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.93Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
25.81Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
25.81Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.81Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
25.81Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3EMLZM-2413853EML-A2A-ZM-241385
25.00Single3OE8IT1t3OE8-CXCR4-IT1t
25.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
25.00Single4QKX35V4QKX-β2-35V
25.00Single5DSGTiotropium5DSG-M4-Tiotropium
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
25.00Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
25.00Single5WF6UK-4320975WF6-A2A-UK-432097
25.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
25.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6GPSMK08126GPS-CCR2-MK0812
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
25.00Single6S0LZM-2413856S0L-A2A-ZM-241385
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
25.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00Single7BU7BI1671077BU7-β1-BI167107
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
25.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
25.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
25.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
25.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
25.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
25.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
24.24Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.24Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
24.14Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
24.14Single6FJ3PTH6FJ3-PTH1-PTH
24.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
24.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.14Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
24.14Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
24.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.14Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
24.14Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
24.14Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7QA8Peptide7QA8-STE2-Peptide
24.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
24.00Single8IEIA1LYA8IEI-GPR156-A1LYA
24.00Single8IEPA1LYA8IEP-GPR156-A1LYA
24.00Single8IEPA1LYA8IEP-GPR156-A1LYA
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
24.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
24.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
24.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
24.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
24.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
23.81Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
23.81Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
23.81Single5CGCHTL142425CGC-mGlu5-HTL14242
23.81Single5IUAQ274563485IUA-A2A-Q27456348-Na
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.81Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.81Single6GPXMK08126GPX-CCR2-MK0812
23.81Single6HLPNetupitant6HLP-NK1-Netupitant
23.81Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
23.81Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.81Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
23.81Single6S0QZM-2413856S0Q-A2A-ZM-241385
23.81Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
23.81Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
23.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
23.81Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
23.81Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
23.81Single8ZMFA1L108ZMF-5-HT2C-A1L10
23.81Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.81Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.81Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.81Consensusep_offOrthosteric Ligandep4_off
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.81Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
23.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
23.53Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
23.53Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusgi_sensoryOrthosteric Ligandgi_opsins
23.53Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
23.53Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
23.53Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.53Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
23.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
23.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
23.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
23.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
23.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.08Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
23.08Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
23.08Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.08Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
23.08Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
23.08Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
23.08Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.08Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.73Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.73Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
22.73Single4BV0Neurotensin4BV0-NTS1-Neurotensin
22.73Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
22.73Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.73Single5TZRMK86665TZR-FFA1-MK8666
22.73Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.73Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
22.73Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
22.73Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.73Single7PX4PSB-21137PX4-A2A-PSB-2113
22.73Single7R0CAVP7R0C-V2-AVP-Arrestin2
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.73Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
22.73Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
22.73Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
22.73Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
22.73Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
22.73Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
22.73Consensusneurotensin_onOrthosteric Ligandnts1_on
22.73Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
22.73Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
22.58Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.58Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
22.58Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
22.58Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
22.58Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.58Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.58Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
22.58Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
22.58Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.58Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.22Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3PBLEticlopride3PBL-D3-Eticlopride
22.22Single6HLLCP999946HLL-NK1-CP99994
22.22Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
22.22Single6TP4ACT-4622066TP4-OX1-ACT-462206
22.22Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
22.22Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
22.22Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
22.22Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
22.22Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
22.22Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
22.22Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
22.22Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.22Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
22.22Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
22.22Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
22.22Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
22.22Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
22.22Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
22.22Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
21.88Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.88Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
21.88Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
21.74Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
21.74Single4XEENeurotensin4XEE-NTS1-Neurotensin
21.74Single4XESNeurotensin4XES-NTS1-Neurotensin
21.74Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
21.74Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
21.74Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
21.74Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
21.74Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.74Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.74Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.74Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.74Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.74Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
21.74Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
21.43Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
21.43Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.43Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.43Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.21Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.21Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
21.21Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.05Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
21.05Single5U09Taranabant5U09-CB1-Taranabant
21.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.05Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7F8YDevazepide7F8Y-CCKA-Devazepide
21.05Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
21.05Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
21.05Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.05Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.05Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
21.05Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
21.05Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
21.05Single9BA0A1AKN9BA0-CB1-A1AKN
21.05Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
21.05Consensusangiotensin_offOrthosteric Ligandat1_off
21.05Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.83Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
20.83Single5CGDHTL142425CGD-mGlu5-HTL14242
20.83Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.83Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
20.83Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensuschemerin_onOrthosteric Ligandcml1_on
20.83Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.83Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.83Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.69Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
20.69Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
20.69Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
20.69Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
20.69Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.69Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
20.69Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.69Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.69Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.51Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
20.00Single3REYXAC3REY-A2A-XAC
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single5UVIZM-2413855UVI-A2A-ZM-241385
20.00Single6KUXRS-799486KUX-α2a-RS-79948
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
20.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.44Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
19.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
19.35Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
19.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
19.23Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
19.23Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
19.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
19.23Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
19.23Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
19.23Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.23Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single2Y01Dobutamine2Y01-β1-Dobutamine
19.05Single4QIMANTA XV4QIM-SMO-ANTA XV
19.05Single5T04Neurotensin5T04-NTS1-Neurotensin
19.05Single6D27CAY104716D27-DP2-CAY10471
19.05Single6IIVDaltroban6IIV-TP-Daltroban
19.05Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
19.05Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
19.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
19.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
19.05Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.05Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
19.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
19.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.75Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
18.75Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
18.75Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.52Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
18.52Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.52Single7XNACYN1548067XNA-SST2-CYN154806
18.52Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.52Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
18.18Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.18Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.18Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
18.18Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.18Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.65Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
17.65Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
17.65Consensussensory_onOrthosteric Ligandopsins_on
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single5V56TC1145V56-SMO-TC114
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.39Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
17.39Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.39Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.39Single9BJKNAM9BJK-μ-Naloxone-NAM
17.39Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
17.39Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
17.39Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.39Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.39Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.39Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
17.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.24Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.24Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.24Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.14Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
17.14Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
16.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
16.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
16.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
16.67Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.67Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
16.13Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
16.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6LI0C176LI0-GPR52-C17
15.79Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
15.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
15.79Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.79Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.79Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
15.79Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Consensusgq_nucleotideOrthosteric Ligandgq_p2y
15.79Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.62Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.38Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.38Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8XQJJN2418XQJ-Apelin-JN241
15.38Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.38Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
15.38Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
15.38Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
15.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
15.38Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
15.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
15.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.81Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
14.81Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Single8XWNCXCL88XWN-CXCR2-CXCL8
14.81Consensussomatostatin_offOrthosteric Ligandsst2_off
14.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
14.29Single6FFIMMPEP6FFI-mGlu5-MMPEP
14.29Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
14.29Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.29Single7VV6C48/807VV6-MRGPRX2-C48/80
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
14.29Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.29Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
14.29Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
14.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
14.29Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
14.29Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
13.79Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.79Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.79Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
13.64Single6FFHFenobam6FFH-mGlu5-Fenobam
13.64Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.64Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
13.64Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.51Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.51Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.33Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.04Single4JKVTaladegib4JKV-SMO-Taladegib
13.04Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
13.04Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.04Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5V57TC1145V57-SMO-TC114
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
12.50Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.00Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.00Single4PY02MeSATP4PY0-P2Y12-2MeSATP
12.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
12.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.00Single8XQJJN2418XQJ-Apelin-JN241
12.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.54Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
11.54Single8XVUCXCL28XVU-CXCR2-CXCL2
11.54Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.11Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
11.11Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
10.53Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.53Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.34Single7SHEPI; PE7SHE-GPR158-PI; PE
10.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.68Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.52Single4QINSAG1.54QIN-SMO-SAG1.5
9.52Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.52Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.52Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.52Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.52Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.52Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.09Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.09Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.09Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.70Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.70Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.69Single8XWACXCL18XWA-CXCR2-CXCL1
7.69Single8XWMCXCL68XWM-CXCR2-CXCL6
7.69Single8XWSCXCL58XWS-CXCR2-CXCL5
7.69Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.41Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.41Single8XWFCXCL38XWF-CXCR2-CXCL3
7.41Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6D35Cholesterol6D35-SMO-Cholesterol
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
7.14Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
7.14Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
7.14Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
7.14Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
7.14Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
7.14Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTTCa7DTT-CaS-Ca-Ca
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTUTryptophan7DTU-CaS-Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
7.14Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
7.14Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
7.14Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
7.14Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
7.14Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
7.14Single7XW7K1-707XW7-TSH-K1-70
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
7.14Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
7.14Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.14Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8WVXNorrin8WVX-LGR4-Norrin
7.14Single8WVYNorrin8WVY-LGR4-Norrin
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
7.14Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
7.14Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
7.14Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
6.90Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.67Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
6.67Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
6.25Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
6.25Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
6.25Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
5.88Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
5.88Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.88Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
5.88Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.88Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.56Single5L7DCholesterol5L7D-SMO-Cholesterol
5.56Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
5.56Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.56Single8HS2Fab0468HS2-GPR20-Fab046
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.56Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
5.56Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.00Single8JPSCCL78JPS-ACKR1-CCL7
5.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.00Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
5.00Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
4.76Single8HNNSCH5467388HNN-CXCR3-SCH546738
4.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.17Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.00Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.33Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.12Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.12Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.03Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.78Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7VIE 7VIE-S1P1-S1P-Gi1/β1/γ2
7VIF 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
7VIG 7VIG-S1P1-CBP-307-Gi1/β1/γ2
7EVY 7EVY-S1P1-Siponimod-Gi1/β1/γ2
7EVZ 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
7EW0 7EW0-S1P1-Ozanimod-Gi1/β1/γ2
7EW7 7EW7-S1P1-SEW2871-Gi1/β1/γ2
Net Summary
Imin 2.64143
Number of Linked Nodes 909
Number of Links 1128
Number of Hubs 179
Number of Links mediated by Hubs 702
Number of Communities 27
Number of Nodes involved in Communities 269
Number of Links involved in Communities 386
Path Summary
Number Of Nodes in MetaPath 130
Number Of Links MetaPath 129
Number of Shortest Paths 1088110
Length Of Smallest Path 3
Average Path Length 26.3266
Length of Longest Path 59
Minimum Path Strength 0.370714
Average Path Strength 5.29415
Maximum Path Strength 18.4907
Minimum Path Correlation 0.712857
Average Path Correlation 0.979333
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 49.7871
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.7692
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
s1p1_off_on_gps1p1_on_gps1p1_off
This network is also present in following consensuses:
IdComponents
s1p_on_gps1p1_on_gp
s1p3_on_gp
s1p5_on_gp



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