psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G42	L:L:K41	1.74	No	No	0	8	6
2	L:L:C46	L:L:K41	12.93	No	No	2	9	6
3	L:L:C52	L:L:K41	6.47	Yes	No	2	9	6
4	L:L:C43	L:L:C46	3.64	Yes	No	2	9	9
5	L:L:C43	L:L:C52	7.28	Yes	Yes	2	9	9
6	L:L:C43	L:L:C55	1.82	Yes	No	2	9	9
7	L:L:C43	L:L:C74	7.28	Yes	Yes	2	9	9
8	L:L:L44	L:L:R54	6.07	No	No	0	5	6
9	L:L:S45	L:L:S53	4.89	No	Yes	2	5	6
10	E:E:L131	L:L:S45	6.01	Yes	No	2	9	5
11	L:L:C46	L:L:C52	7.28	No	Yes	2	9	9
12	L:L:N50	L:L:S47	5.96	Yes	No	2	9	9
13	L:L:G51	L:L:S47	1.86	No	No	0	9	9
14	E:E:E127	L:L:S47	4.31	Yes	No	2	9	9
15	E:E:K125	L:L:D49	9.68	No	No	18	9	6
16	E:E:M192	L:L:D49	8.32	No	No	18	9	6
17	E:E:N196	L:L:D49	6.73	No	No	0	9	6
18	E:E:H102	L:L:N50	11.48	Yes	Yes	2	9	9
19	E:E:P103	L:L:N50	9.77	No	Yes	2	9	9
20	E:E:E127	L:L:N50	10.52	Yes	Yes	2	9	9
21	L:L:C52	L:L:C74	1.82	Yes	Yes	2	9	9
22	E:E:H102	L:L:S53	2.79	Yes	Yes	2	9	6
23	E:E:E127	L:L:S53	8.62	Yes	Yes	2	9	6
24	E:E:L131	L:L:S53	3	Yes	Yes	2	9	6
25	L:L:M90	L:L:R54	4.96	No	No	0	5	6
26	L:L:C55	L:L:F61	5.59	No	Yes	2	9	7
27	L:L:C55	L:L:C74	7.28	No	Yes	2	9	9
28	L:L:Q56	L:L:Q57	3.84	No	No	0	6	7
29	L:L:L59	L:L:Q56	5.32	No	No	0	7	6
30	L:L:K58	L:L:Q57	2.71	No	No	0	8	7
31	L:L:K58	R:R:N114	5.6	No	Yes	0	8	9
32	L:L:K58	R:R:D162	6.91	No	Yes	0	8	9
33	L:L:C74	L:L:L59	3.17	Yes	No	0	9	7
34	L:L:H76	L:L:L59	11.57	Yes	No	0	7	7
35	L:L:F60	L:L:G84	4.52	No	No	0	9	8
36	L:L:F60	L:L:R86	14.97	No	Yes	3	9	9
37	L:L:F60	L:L:N91	2.42	No	No	3	9	9
38	L:L:F61	L:L:L63	7.31	Yes	Yes	2	7	9
39	L:L:F61	L:L:G72	3.01	Yes	No	2	7	9
40	L:L:F61	L:L:M90	4.98	Yes	No	2	7	5
41	E:E:H102	L:L:F61	3.39	Yes	Yes	2	9	7
42	E:E:L104	L:L:F61	3.65	No	Yes	2	9	7
43	L:L:F62	L:L:R64	12.83	Yes	Yes	12	6	6
44	L:L:E73	L:L:F62	5.83	No	Yes	12	7	6
45	L:L:F62	L:L:L75	3.65	Yes	No	12	6	6
46	L:L:F62	L:L:P79	4.33	Yes	Yes	12	6	9
47	L:L:F62	L:L:Y82	13.41	Yes	Yes	12	6	8
48	L:L:C93	L:L:F62	4.19	Yes	Yes	12	9	6
49	L:L:L63	L:L:Q70	7.99	Yes	No	2	9	8
50	L:L:G72	L:L:L63	1.71	No	Yes	2	9	9
51	E:E:H102	L:L:L63	6.43	Yes	Yes	2	9	9
52	E:E:G105	L:L:L63	1.71	No	Yes	0	9	9
53	L:L:E66	L:L:R64	2.33	No	Yes	12	5	6
54	L:L:R64	L:L:Y71	7.2	Yes	No	12	6	6
55	L:L:E73	L:L:R64	10.47	No	Yes	12	7	6
56	L:L:Q70	L:L:R65	16.35	No	Yes	2	8	9
57	E:E:V99	L:L:R65	3.92	No	Yes	0	7	9
58	E:E:M101	L:L:R65	2.48	Yes	Yes	2	9	9
59	E:E:Y116	L:L:R65	14.4	Yes	Yes	2	9	9
60	L:L:E66	L:L:Y71	11.22	No	No	12	5	6
61	E:E:E97	L:L:M68	2.71	Yes	No	2	7	8
62	E:E:I98	L:L:M68	5.83	Yes	No	2	8	8
63	L:L:R69	L:L:Y71	7.2	No	No	0	8	6
64	E:E:Q100	L:L:R69	2.34	No	No	0	7	8
65	E:E:N196	L:L:R69	3.62	No	No	0	9	8
66	E:E:H102	L:L:Q70	2.47	Yes	No	2	9	8
67	L:L:E73	L:L:L75	6.63	No	No	12	7	6
68	L:L:H76	R:R:M66	13.13	Yes	Yes	3	7	9
69	L:L:H76	R:R:G90	4.77	Yes	No	3	7	9
70	L:L:H76	R:R:N114	10.2	Yes	Yes	3	7	9
71	L:L:S77	R:R:Q113	2.89	No	Yes	0	7	9
72	L:L:C78	L:L:P79	3.77	Yes	Yes	12	9	9
73	L:L:C78	L:L:Y82	2.69	Yes	Yes	12	9	8
74	L:L:C78	L:L:G84	1.96	Yes	No	0	9	8
75	L:L:C78	L:L:C93	7.28	Yes	Yes	12	9	9
76	L:L:P79	L:L:Y82	9.74	Yes	Yes	12	9	8
77	L:L:C93	L:L:P79	1.88	Yes	Yes	12	9	9
78	L:L:G81	L:L:S80	1.86	No	No	0	9	3
79	L:L:C96	L:L:G81	1.96	No	No	0	9	9
80	L:L:C93	L:L:Y82	4.03	Yes	Yes	12	9	8
81	L:L:R95	L:L:Y82	16.46	No	Yes	0	7	8
82	L:L:A94	L:L:Y83	6.67	No	No	0	5	5
83	L:L:C104	L:L:Y83	4.03	No	No	0	9	5
84	L:L:K107	L:L:Y83	4.78	No	No	0	5	5
85	L:L:H85	L:L:R92	4.51	No	No	0	4	6
86	L:L:H85	R:R:H209	5.97	No	Yes	0	4	9
87	L:L:N91	L:L:R86	9.64	No	Yes	3	9	9
88	L:L:R86	R:R:D137	11.91	Yes	Yes	3	9	9
89	L:L:R86	R:R:A138	4.15	Yes	No	3	9	9
90	L:L:R86	R:R:D161	8.34	Yes	Yes	3	9	9
91	L:L:R86	R:R:D162	3.57	Yes	Yes	3	9	9
92	L:L:A87	L:L:P88	1.87	No	No	0	7	5
93	L:L:A87	L:L:D89	3.09	No	No	0	7	6
94	L:L:P88	R:R:L186	3.28	No	No	3	5	9
95	L:L:P88	R:R:N210	4.89	No	Yes	3	5	9
96	E:E:L104	L:L:M90	2.83	No	No	2	9	5
97	L:L:R95	L:L:R97	10.66	No	No	0	7	5
98	L:L:C104	L:L:C96	3.64	No	No	0	9	9
99	E:E:E112	L:L:R97	5.82	No	No	0	9	5
100	L:L:C101	L:L:I98	6.55	No	No	14	9	6
101	L:L:C110	L:L:I98	3.27	No	No	14	9	6
102	L:L:E99	L:L:N100	6.57	No	No	0	4	8
103	L:L:F117	L:L:N100	19.33	Yes	No	14	5	8
104	L:L:C124	L:L:N100	4.72	No	No	14	9	8
105	L:L:C101	L:L:C104	1.82	No	No	0	9	9
106	L:L:C101	L:L:C110	7.28	No	No	14	9	9
107	L:L:D102	L:L:K114	16.59	No	No	0	6	7
108	L:L:K112	L:L:S103	3.06	No	No	0	7	5
109	L:L:F105	L:L:S106	2.64	Yes	No	3	9	8
110	L:L:F105	L:L:F109	6.43	Yes	Yes	3	9	8
111	L:L:F105	R:R:H157	3.39	Yes	Yes	3	9	9
112	L:L:F105	R:R:W159	13.03	Yes	Yes	3	9	9
113	L:L:F105	R:R:A181	8.32	Yes	No	0	9	9
114	L:L:F105	R:R:T183	2.59	Yes	Yes	3	9	9
115	L:L:F105	R:R:H207	2.26	Yes	Yes	3	9	9
116	L:L:S106	R:R:H207	5.58	No	Yes	3	8	9
117	L:L:D108	L:L:K107	9.68	No	No	0	8	5
118	L:L:K107	R:R:E252	8.1	No	Yes	0	5	9
119	L:L:D108	L:L:R123	5.96	No	No	0	8	6
120	L:L:F109	L:L:G122	6.02	Yes	No	0	8	9
121	L:L:F109	R:R:H157	5.66	Yes	Yes	3	8	9
122	L:L:F109	R:R:Q180	2.34	Yes	Yes	3	8	9
123	L:L:F109	R:R:V204	6.55	Yes	Yes	3	8	9
124	L:L:F109	R:R:V205	5.24	Yes	Yes	3	8	9
125	L:L:C110	L:L:C113	1.82	No	Yes	14	9	9
126	L:L:T111	R:R:H157	8.21	No	Yes	0	8	9
127	L:L:C113	L:L:F117	4.19	Yes	Yes	14	9	5
128	L:L:C113	L:L:L119	3.17	Yes	No	0	9	7
129	L:L:C113	L:L:C124	7.28	Yes	No	14	9	9
130	L:L:G116	L:L:V115	3.68	No	No	0	7	4
131	L:L:F117	L:L:G116	4.52	Yes	No	0	5	7
132	L:L:C124	L:L:F117	2.79	No	Yes	14	9	5
133	L:L:D126	L:L:F117	8.36	No	Yes	0	3	5
134	L:L:P134	L:L:Y118	5.56	No	No	0	5	5
135	L:L:L135	L:L:Y118	9.38	No	No	22	5	5
136	L:L:M139	L:L:Y118	3.59	No	No	22	7	5
137	L:L:H120	L:L:R121	5.64	No	No	0	5	5
138	L:L:F125	L:L:H120	5.66	No	No	0	5	5
139	L:L:F132	L:L:H120	6.79	No	No	0	5	5
140	L:L:R121	R:R:N226	4.82	No	No	0	5	8
141	L:L:C128	L:L:F125	2.79	Yes	No	0	9	5
142	L:L:C128	L:L:P129	1.88	Yes	No	0	9	9
143	L:L:C128	L:L:P134	3.77	Yes	No	0	9	5
144	L:L:C128	L:L:C141	7.28	Yes	No	0	9	9
145	L:L:F132	L:L:G131	3.01	No	No	0	5	6
146	L:L:A133	L:L:P134	1.87	No	No	0	3	5
147	L:L:A133	L:L:D136	4.63	No	No	0	3	5
148	L:L:E137	L:L:L135	5.3	No	No	0	4	5
149	L:L:L135	L:L:M139	2.83	No	No	22	5	7
150	L:L:E140	L:L:T138	5.64	No	No	0	8	6
151	L:L:E140	R:R:R156	5.82	No	Yes	0	8	9
152	M:M:C46	M:M:K41	3.23	No	No	4	9	6
153	M:M:C52	M:M:K41	6.47	No	No	4	9	6
154	M:M:G42	M:M:L59	1.71	No	Yes	0	8	7
155	M:M:C43	M:M:S45	1.72	Yes	No	4	9	5
156	M:M:C43	M:M:C46	3.64	Yes	No	4	9	9
157	M:M:C43	M:M:C52	7.28	Yes	No	4	9	9
158	M:M:C43	M:M:C74	1.82	Yes	No	0	9	9
159	M:M:L44	M:M:R54	9.72	No	No	0	5	6
160	M:M:S45	M:M:S53	4.89	No	No	4	5	6
161	M:M:S45	T:T:L131	3	No	Yes	4	5	9
162	M:M:C46	M:M:C52	7.28	No	No	4	9	9
163	M:M:D49	M:M:S47	2.94	Yes	Yes	4	6	9
164	M:M:N50	M:M:S47	5.96	Yes	Yes	4	9	9
165	M:M:G51	M:M:S47	1.86	No	Yes	0	9	9
166	M:M:S47	T:T:K125	3.06	Yes	Yes	4	9	9
167	M:M:D49	T:T:K125	12.44	Yes	Yes	4	6	9
168	M:M:D49	T:T:M192	8.32	Yes	Yes	4	6	9
169	M:M:D49	T:T:N196	4.04	Yes	Yes	4	6	9
170	M:M:N50	T:T:H102	14.03	Yes	Yes	4	9	9
171	M:M:N50	T:T:P103	6.52	Yes	Yes	4	9	9
172	M:M:N50	T:T:K125	2.8	Yes	Yes	4	9	9
173	M:M:S53	T:T:H102	2.79	No	Yes	4	6	9
174	M:M:S53	T:T:L131	4.5	No	Yes	4	6	9
175	M:M:M90	M:M:R54	7.44	Yes	No	0	5	6
176	M:M:R54	T:T:L131	2.43	No	Yes	0	6	9
177	M:M:C55	M:M:F61	6.98	No	Yes	0	9	7
178	M:M:C55	M:M:C74	7.28	No	No	0	9	9
179	M:M:Q56	M:M:Q57	2.56	No	No	0	6	7
180	M:M:K58	M:M:Q56	8.14	No	No	0	8	6
181	M:M:L59	M:M:Q56	2.66	Yes	No	0	7	6
182	M:M:N91	M:M:Q57	9.24	No	No	0	9	7
183	M:M:C74	M:M:L59	3.17	No	Yes	0	9	7
184	M:M:H76	M:M:L59	7.71	No	Yes	0	7	7
185	M:M:F60	M:M:G84	4.52	No	No	0	9	8
186	M:M:F60	M:M:R86	12.83	No	No	23	9	9
187	M:M:F60	M:M:N91	3.62	No	No	23	9	9
188	M:M:F61	M:M:L63	6.09	Yes	Yes	4	7	9
189	M:M:F61	M:M:G72	3.01	Yes	Yes	4	7	9
190	M:M:F61	M:M:M90	8.71	Yes	Yes	4	7	5
191	M:M:F61	T:T:H102	3.39	Yes	Yes	4	7	9
192	M:M:F61	T:T:L104	6.09	Yes	Yes	4	7	9
193	M:M:F62	M:M:R64	8.55	Yes	Yes	4	6	6
194	M:M:E73	M:M:F62	9.33	Yes	Yes	4	7	6
195	M:M:F62	M:M:L75	2.44	Yes	No	4	6	6
196	M:M:F62	M:M:P79	8.67	Yes	Yes	4	6	9
197	M:M:F62	M:M:Y82	14.44	Yes	Yes	4	6	8
198	M:M:C93	M:M:F62	5.59	Yes	Yes	4	9	6
199	M:M:L63	M:M:Q70	5.32	Yes	No	0	9	8
200	M:M:G72	M:M:L63	1.71	Yes	Yes	4	9	9
201	M:M:L63	T:T:H102	5.14	Yes	Yes	4	9	9
202	M:M:L63	T:T:G105	1.71	Yes	No	0	9	9
203	M:M:E66	M:M:R64	5.82	No	Yes	4	5	6
204	M:M:R64	M:M:Y71	10.29	Yes	Yes	4	6	6
205	M:M:E73	M:M:R64	16.28	Yes	Yes	4	7	6
206	M:M:Q70	M:M:R65	22.2	No	No	0	8	9
207	M:M:R65	T:T:V99	3.92	No	No	0	9	7
208	M:M:R65	T:T:Y116	7.2	No	Yes	0	9	9
209	M:M:E66	M:M:R69	2.33	No	No	4	5	8
210	M:M:E66	M:M:Y71	10.1	No	Yes	4	5	6
211	M:M:M68	T:T:I98	5.83	No	No	0	8	8
212	M:M:M68	T:T:V195	4.56	No	No	0	8	9
213	M:M:M68	T:T:A201	3.22	No	No	0	8	9
214	M:M:R69	M:M:Y71	7.2	No	Yes	4	8	6
215	M:M:R69	T:T:N196	3.62	No	Yes	4	8	9
216	M:M:G72	M:M:Y71	2.9	Yes	Yes	4	9	6
217	M:M:E73	M:M:Y71	2.24	Yes	Yes	4	7	6
218	M:M:G72	T:T:H102	3.18	Yes	Yes	4	9	9
219	M:M:E73	M:M:L75	2.65	Yes	No	4	7	6
220	M:M:L75	M:M:P79	3.28	No	Yes	4	6	9
221	M:M:C78	M:M:P79	1.88	Yes	Yes	4	9	9
222	M:M:C78	M:M:Y82	2.69	Yes	Yes	4	9	8
223	M:M:C78	M:M:G84	1.96	Yes	No	0	9	8
224	M:M:C78	M:M:C93	7.28	Yes	Yes	4	9	9
225	M:M:P79	M:M:Y82	8.34	Yes	Yes	4	9	8
226	M:M:C93	M:M:P79	1.88	Yes	Yes	4	9	9
227	M:M:G81	M:M:S80	1.86	No	No	0	9	3
228	M:M:G81	M:M:Y82	2.9	No	Yes	0	9	8
229	M:M:C96	M:M:G81	3.92	No	No	0	9	9
230	M:M:C93	M:M:Y82	2.69	Yes	Yes	4	9	8
231	M:M:R95	M:M:Y82	9.26	No	Yes	0	7	8
232	M:M:H85	M:M:Y83	2.18	No	Yes	0	4	5
233	M:M:A94	M:M:Y83	6.67	No	Yes	0	5	5
234	M:M:C104	M:M:Y83	4.03	Yes	Yes	9	9	5
235	M:M:K107	M:M:Y83	10.75	No	Yes	9	5	5
236	M:M:Y83	T:T:D111	5.75	Yes	No	9	5	9
237	M:M:A87	M:M:H85	2.93	No	No	0	7	4
238	M:M:N91	M:M:R86	15.67	No	No	23	9	9
239	M:M:A87	M:M:P88	1.87	No	No	0	7	5
240	M:M:A87	M:M:D89	3.09	No	No	0	7	6
241	M:M:D89	M:M:M90	2.77	No	Yes	0	6	5
242	M:M:D89	M:M:R92	4.76	No	No	0	6	6
243	M:M:M90	T:T:L104	2.83	Yes	Yes	4	5	9
244	M:M:C96	M:M:R95	6.96	No	No	0	9	7
245	M:M:R95	M:M:R97	7.46	No	No	0	7	5
246	M:M:C104	M:M:C96	1.82	Yes	No	0	9	9
247	M:M:R97	T:T:E112	13.96	No	No	0	5	9
248	M:M:C101	M:M:I98	6.55	No	No	9	9	6
249	M:M:C104	M:M:I98	3.27	Yes	No	9	9	6
250	M:M:C110	M:M:I98	3.27	Yes	No	9	9	6
251	M:M:E99	M:M:N100	11.83	No	No	0	4	8
252	M:M:F117	M:M:N100	18.12	Yes	No	9	5	8
253	M:M:C124	M:M:N100	3.15	Yes	No	9	9	8
254	M:M:C101	M:M:C104	3.64	No	Yes	9	9	9
255	M:M:C101	M:M:C110	7.28	No	Yes	9	9	9
256	M:M:D102	M:M:K112	2.77	No	No	0	6	7
257	M:M:D102	M:M:K114	11.06	No	No	0	6	7
258	M:M:K112	M:M:S103	7.65	No	No	0	7	5
259	M:M:C104	M:M:C110	1.82	Yes	Yes	9	9	9
260	M:M:F105	M:M:S106	2.64	No	No	0	9	8
261	M:M:F105	M:M:F109	4.29	No	No	0	9	8
262	M:M:D108	M:M:K107	8.3	No	No	0	8	5
263	M:M:K107	T:T:D111	6.91	No	No	9	5	9
264	M:M:D108	M:M:R123	5.96	No	No	0	8	6
265	M:M:F109	M:M:T111	2.59	No	No	0	8	8
266	M:M:F109	M:M:G122	3.01	No	No	0	8	9
267	M:M:C110	M:M:C113	1.82	Yes	Yes	9	9	9
268	M:M:C110	M:M:C124	1.82	Yes	Yes	9	9	9
269	M:M:C113	M:M:F117	2.79	Yes	Yes	9	9	5
270	M:M:C113	M:M:C124	7.28	Yes	Yes	9	9	9
271	M:M:G116	M:M:V115	1.84	No	No	0	7	4
272	M:M:F117	M:M:G116	3.01	Yes	No	0	5	7
273	M:M:C124	M:M:F117	4.19	Yes	Yes	9	9	5
274	M:M:D126	M:M:F117	7.17	No	Yes	0	3	5
275	M:M:P134	M:M:Y118	4.17	No	No	0	5	5
276	M:M:L135	M:M:Y118	3.52	No	No	0	5	5
277	M:M:M139	M:M:Y118	5.99	No	No	0	7	5
278	M:M:E140	M:M:L119	18.55	No	No	0	8	7
279	M:M:F125	M:M:H120	2.26	No	No	0	5	5
280	M:M:H120	M:M:P129	3.05	No	No	0	5	9
281	M:M:F132	M:M:H120	2.26	No	No	0	5	5
282	M:M:G122	M:M:R123	3	No	No	0	9	6
283	M:M:F125	M:M:R123	5.34	No	No	0	5	6
284	M:M:C128	M:M:P129	1.88	No	No	0	9	9
285	M:M:C128	M:M:P134	3.77	No	No	0	9	5
286	M:M:C128	M:M:C141	7.28	No	No	0	9	9
287	M:M:F132	M:M:G131	3.01	No	No	0	5	6
288	M:M:A133	M:M:P134	1.87	No	No	0	3	5
289	M:M:A133	M:M:D136	4.63	No	No	0	3	5
290	M:M:E140	M:M:T138	5.64	No	No	0	8	6
291	E:E:K56	E:E:R84	6.19	No	No	0	8	8
292	E:E:K56	E:E:R87	3.71	No	No	0	8	5
293	E:E:E57	E:E:F85	2.33	No	Yes	2	8	8
294	E:E:E57	E:E:H207	9.85	No	No	2	8	9
295	E:E:T58	E:E:T82	4.71	No	No	0	8	8
296	E:E:R84	E:E:T58	5.17	No	No	0	8	8
297	E:E:A59	E:E:F85	8.32	No	Yes	0	9	8
298	E:E:L81	E:E:V61	5.96	No	No	0	8	9
299	E:E:I205	E:E:V61	4.61	No	No	0	9	9
300	E:E:E62	E:E:T78	2.82	No	No	0	9	9
301	E:E:E62	E:E:G80	3.27	No	No	0	9	7
302	E:E:T79	E:E:V63	3.17	No	No	0	9	9
303	E:E:T76	E:E:V64	4.76	No	No	8	9	9
304	E:E:T78	E:E:V64	4.76	No	No	0	9	9
305	E:E:V64	T:T:Y118	2.52	No	Yes	8	9	9
306	E:E:L65	E:E:Y77	7.03	No	No	0	9	6
307	E:E:L65	E:E:Q198	6.65	No	No	0	9	9
308	E:E:F66	E:E:Y74	3.09	Yes	Yes	8	9	9
309	E:E:F66	E:E:V200	5.24	Yes	No	0	9	9
310	E:E:F66	E:E:R202	3.21	Yes	Yes	8	9	9
311	E:E:F66	T:T:Y118	11.35	Yes	Yes	8	9	9
312	E:E:E67	E:E:Y77	2.24	No	No	0	9	6
313	E:E:S68	E:E:Y74	8.9	No	Yes	0	9	9
314	E:E:P70	E:E:S69	3.56	No	No	0	6	9
315	E:E:G72	E:E:S69	1.86	No	No	0	9	9
316	E:E:S71	T:T:E112	8.62	No	No	0	6	9
317	E:E:D73	T:T:Q148	3.92	No	No	0	8	9
318	E:E:Y74	T:T:Y118	9.93	Yes	Yes	8	9	9
319	E:E:Y74	T:T:G150	5.79	Yes	No	8	9	9
320	E:E:T75	E:E:Y77	6.24	No	No	0	8	6
321	E:E:T76	T:T:Y118	6.24	No	Yes	8	9	9
322	E:E:K190	E:E:T79	4.5	No	No	0	9	9
323	E:E:G83	E:E:T82	1.82	No	No	0	8	8
324	E:E:G83	E:E:V181	1.84	No	No	0	8	9
325	E:E:G83	E:E:V183	1.84	No	Yes	0	8	9
326	E:E:R84	E:E:Y182	8.23	No	Yes	0	8	9
327	E:E:F85	E:E:T91	5.19	Yes	No	2	8	8
328	E:E:F85	E:E:P179	2.89	Yes	Yes	2	8	9
329	E:E:F85	E:E:V181	3.93	Yes	No	0	8	9
330	E:E:F85	E:E:I205	2.51	Yes	No	0	8	9
331	E:E:F85	E:E:H207	5.66	Yes	No	2	8	9
332	E:E:A88	E:E:S86	1.71	Yes	Yes	10	9	9
333	E:E:L168	E:E:S86	9.01	No	Yes	0	9	9
334	E:E:S86	E:E:V180	3.23	Yes	Yes	10	9	9
335	E:E:S86	E:E:Y182	2.54	Yes	Yes	10	9	9
336	E:E:R87	E:E:S172	2.64	No	No	0	5	5
337	E:E:A88	E:E:G89	1.95	Yes	No	10	9	9
338	E:E:A88	E:E:V180	3.39	Yes	Yes	10	9	9
339	E:E:G89	E:E:L176	1.71	No	No	0	9	9
340	E:E:G89	E:E:V180	1.84	No	Yes	10	9	9
341	E:E:A90	E:E:L92	3.15	No	No	0	9	7
342	E:E:H207	E:E:T91	6.85	No	No	2	9	8
343	E:E:L92	E:E:R178	3.64	No	Yes	2	7	9
344	E:E:L92	E:E:P179	4.93	No	Yes	2	7	9
345	E:E:S93	T:T:S93	6.52	No	No	0	9	9
346	E:E:A94	E:E:T152	3.36	No	Yes	2	9	9
347	E:E:A153	E:E:A94	1.79	No	No	2	9	9
348	E:E:A94	E:E:P179	1.87	No	Yes	2	9	9
349	E:E:E95	E:E:R202	10.47	No	Yes	0	8	9
350	E:E:E95	E:E:R204	9.3	No	No	0	8	9
351	E:E:E95	T:T:T152	7.06	No	No	0	8	9
352	E:E:G96	E:E:V121	1.84	No	Yes	0	8	9
353	E:E:G96	E:E:R202	4.5	No	Yes	0	8	9
354	E:E:E97	E:E:I98	2.73	Yes	Yes	2	7	8
355	E:E:E97	E:E:V200	2.85	Yes	No	0	7	9
356	E:E:I98	E:E:V121	3.07	Yes	Yes	2	8	9
357	E:E:I98	E:E:V123	3.07	Yes	No	0	8	9
358	E:E:A203	E:E:I98	4.87	No	Yes	2	9	8
359	E:E:V99	E:E:W120	9.81	No	Yes	0	7	9
360	E:E:Q100	E:E:V195	4.3	No	No	0	7	9
361	E:E:L106	E:E:M101	2.83	No	Yes	0	9	9
362	E:E:M101	E:E:Y116	7.18	Yes	Yes	2	9	9
363	E:E:M101	E:E:W120	6.98	Yes	Yes	2	9	9
364	E:E:H102	E:E:P103	12.2	Yes	No	2	9	9
365	E:E:H102	E:E:L104	7.71	Yes	No	2	9	9
366	E:E:P103	E:E:V124	1.77	No	No	0	9	9
367	E:E:K142	E:E:L106	4.23	No	No	0	7	9
368	E:E:C107	E:E:C136	7.28	No	No	0	9	9
369	E:E:N108	E:E:N109	4.09	No	No	0	9	8
370	E:E:L137	E:E:N108	12.36	No	No	0	9	9
371	E:E:D111	E:E:N110	4.04	No	No	0	9	9
372	E:E:E113	E:E:N110	11.83	Yes	No	0	9	9
373	E:E:E112	E:E:E113	2.54	No	Yes	0	9	9
374	E:E:E112	T:T:S71	2.87	No	No	0	9	6
375	E:E:D114	E:E:E113	2.6	No	Yes	0	9	9
376	E:E:E113	E:E:R149	9.3	Yes	Yes	0	9	9
377	E:E:D114	E:E:Y116	11.49	No	Yes	0	9	9
378	E:E:L115	T:T:Y74	4.69	No	Yes	0	8	9
379	E:E:W120	E:E:Y116	1.93	Yes	Yes	2	9	9
380	E:E:R149	E:E:Y116	2.06	Yes	Yes	2	9	9
381	E:E:G119	E:E:Y118	4.35	No	Yes	2	9	9
382	E:E:G150	E:E:Y118	2.9	No	Yes	2	9	9
383	E:E:Y118	T:T:V64	3.79	Yes	No	0	9	9
384	E:E:Y118	T:T:F66	15.47	Yes	Yes	2	9	9
385	E:E:Y118	T:T:Y74	8.94	Yes	Yes	2	9	9
386	E:E:Y118	T:T:T76	6.24	Yes	No	0	9	9
387	E:E:G119	E:E:T152	5.46	No	Yes	2	9	9
388	E:E:G119	T:T:R202	4.5	No	Yes	2	9	9
389	E:E:G122	E:E:W120	4.22	No	Yes	0	9	9
390	E:E:A146	E:E:W120	2.59	No	Yes	0	9	9
391	E:E:R149	E:E:W120	5	Yes	Yes	2	9	9
392	E:E:G150	E:E:W120	2.81	No	Yes	2	9	9
393	E:E:A151	E:E:W120	10.37	No	Yes	0	9	9
394	E:E:A153	E:E:V121	1.7	No	Yes	2	9	9
395	E:E:A203	E:E:V121	5.09	No	Yes	2	9	9
396	E:E:F156	E:E:V124	6.55	Yes	No	0	9	9
397	E:E:D157	E:E:K125	4.15	Yes	No	18	9	9
398	E:E:K125	E:E:M192	5.76	No	No	18	9	9
399	E:E:F156	E:E:L126	3.65	Yes	No	0	9	9
400	E:E:E127	E:E:L131	2.65	Yes	Yes	2	9	9
401	E:E:E130	E:E:Q128	14.02	No	No	0	6	9
402	E:E:E160	E:E:Q128	5.1	No	No	0	9	9
403	E:E:E130	E:E:P129	3.14	No	No	0	6	9
404	E:E:N161	E:E:P129	13.03	Yes	No	0	9	9
405	E:E:D132	E:E:L131	5.43	No	Yes	0	9	9
406	E:E:C136	E:E:L137	3.17	No	No	0	9	9
407	E:E:G141	E:E:T138	1.82	No	No	0	6	9
408	E:E:F156	E:E:V139	3.93	Yes	No	0	9	9
409	E:E:A164	E:E:V139	1.7	No	No	0	9	9
410	E:E:L168	E:E:V139	5.96	No	No	0	9	9
411	E:E:G171	E:E:L140	1.71	No	No	0	5	9
412	E:E:G141	E:E:K144	3.49	No	No	0	6	9
413	E:E:A143	E:E:V154	1.7	No	Yes	10	9	9
414	E:E:A143	E:E:F156	2.77	No	Yes	10	9	9
415	E:E:A143	E:E:V180	1.7	No	Yes	10	9	9
416	E:E:K144	E:E:Q148	2.71	No	No	0	9	9
417	E:E:R145	E:E:R149	5.33	No	Yes	0	9	9
418	E:E:A146	E:E:V154	1.7	No	Yes	0	9	9
419	E:E:L176	E:E:V147	2.98	No	No	0	9	9
420	E:E:Q148	T:T:D73	2.61	No	No	0	9	8
421	E:E:G150	T:T:Y74	4.35	No	Yes	2	9	9
422	E:E:R178	E:E:T152	6.47	Yes	Yes	2	9	9
423	E:E:T152	T:T:E95	5.64	Yes	Yes	2	9	8
424	E:E:T152	T:T:R202	2.59	Yes	Yes	2	9	9
425	E:E:A153	E:E:P179	1.87	No	Yes	2	9	9
426	E:E:F156	E:E:V154	6.55	Yes	Yes	10	9	9
427	E:E:V154	E:E:V180	4.81	Yes	Yes	10	9	9
428	E:E:I155	E:E:V183	3.07	No	Yes	0	9	9
429	E:E:F156	E:E:V180	2.62	Yes	Yes	10	9	9
430	E:E:D157	E:E:S159	4.42	Yes	No	0	9	9
431	E:E:A188	E:E:D157	4.63	No	Yes	0	9	9
432	E:E:D157	E:E:M192	6.93	Yes	No	18	9	9
433	E:E:A164	E:E:V158	1.7	No	Yes	0	9	9
434	E:E:I165	E:E:V158	4.61	Yes	Yes	10	9	9
435	E:E:V158	E:E:Y182	5.05	Yes	Yes	10	9	9
436	E:E:K184	E:E:V158	4.55	No	Yes	10	9	9
437	E:E:N161	E:E:P162	3.26	Yes	No	24	9	7
438	E:E:E163	E:E:N161	6.57	No	Yes	24	8	9
439	E:E:A164	E:E:N161	3.13	No	Yes	0	9	9
440	E:E:E163	E:E:P162	4.72	No	No	24	8	7
441	E:E:I165	E:E:N169	2.83	Yes	No	0	9	9
442	E:E:I165	E:E:Y182	10.88	Yes	Yes	10	9	9
443	E:E:I165	E:E:K184	4.36	Yes	No	10	9	9
444	E:E:E173	E:E:Q170	3.82	No	No	0	9	8
445	E:E:E173	E:E:G171	4.91	No	No	0	9	5
446	E:E:D174	E:E:P175	4.83	No	No	0	9	9
447	E:E:K177	R:R:N417	5.6	No	No	2	9	7
448	E:E:K177	R:R:Q438	14.92	No	Yes	2	9	9
449	E:E:P179	E:E:R178	8.65	Yes	Yes	2	9	9
450	E:E:R178	T:T:E95	2.33	Yes	Yes	2	9	8
451	E:E:R178	T:T:R204	10.66	Yes	Yes	2	9	9
452	E:E:K184	E:E:Y182	2.39	No	Yes	10	9	9
453	E:E:D187	E:E:V183	5.84	No	Yes	0	9	9
454	E:E:A188	E:E:V183	3.39	No	Yes	0	9	9
455	E:E:I189	E:E:N193	4.25	No	No	0	5	9
456	E:E:I194	E:E:K190	2.91	No	No	0	9	9
457	E:E:K197	E:E:N193	2.8	No	No	0	9	9
458	E:E:K199	E:E:V200	3.04	No	No	0	9	9
459	E:E:R202	T:T:Y118	5.14	Yes	Yes	8	9	9
460	E:E:R202	T:T:G119	3	Yes	No	8	9	9
461	E:E:R204	T:T:R178	17.06	No	Yes	0	9	9
462	E:E:Q206	T:T:L92	10.65	No	No	0	9	7
463	R:R:C33	R:R:V41	1.71	Yes	Yes	6	9	7
464	R:R:C33	R:R:C43	7.28	Yes	Yes	6	9	8
465	R:R:C33	R:R:P52	3.77	Yes	Yes	6	9	8
466	R:R:D36	R:R:D38	5.32	No	No	0	5	6
467	R:R:D38	R:R:R40	4.76	No	No	0	6	3
468	R:R:Q60	R:R:R39	12.85	No	No	0	5	7
469	R:R:A61	R:R:R40	8.3	No	No	25	4	3
470	R:R:E85	R:R:R40	2.33	No	No	25	8	3
471	R:R:C43	R:R:V41	1.71	Yes	Yes	6	8	7
472	R:R:L55	R:R:V41	5.96	Yes	Yes	0	6	7
473	R:R:T59	R:R:V41	4.76	No	Yes	0	8	7
474	R:R:L62	R:R:V41	2.98	Yes	Yes	6	5	7
475	R:R:D42	R:R:S44	4.42	No	Yes	3	9	7
476	R:R:D42	R:R:D63	6.65	No	Yes	3	9	9
477	R:R:C43	R:R:P52	3.77	Yes	Yes	6	8	8
478	R:R:C43	R:R:I64	3.27	Yes	Yes	6	8	6
479	R:R:G45	R:R:S44	1.86	No	Yes	3	8	7
480	R:R:D63	R:R:S44	2.94	Yes	Yes	3	9	7
481	R:R:S44	R:R:S65	4.89	Yes	Yes	3	7	9
482	R:R:M66	R:R:S44	4.6	Yes	Yes	3	9	7
483	R:R:G45	R:R:M66	1.75	No	Yes	3	8	9
484	R:R:G47	R:R:N67	1.7	No	Yes	0	7	9
485	R:R:L48	R:R:P52	4.93	No	Yes	0	8	8
486	R:R:L48	R:R:N67	8.24	No	Yes	0	8	9
487	R:R:P52	R:R:V51	3.53	Yes	No	6	8	5
488	R:R:A76	R:R:V51	1.7	No	No	6	4	5
489	R:R:F77	R:R:V51	3.93	Yes	No	6	7	5
490	R:R:L55	R:R:P52	3.28	Yes	Yes	0	6	8
491	R:R:I64	R:R:P52	3.39	Yes	Yes	6	6	8
492	R:R:E53	R:R:N79	11.83	No	No	0	2	4
493	R:R:F80	R:R:L55	7.31	Yes	Yes	0	7	6
494	R:R:A57	R:R:P81	1.87	No	No	0	4	5
495	R:R:F58	R:R:F82	3.22	No	No	0	6	5
496	R:R:F80	R:R:T59	2.59	Yes	No	0	7	8
497	R:R:E84	R:R:Q60	6.37	No	No	0	6	5
498	R:R:A61	R:R:E85	3.02	No	No	25	4	8
499	R:R:I64	R:R:L62	8.56	Yes	Yes	6	6	5
500	R:R:F77	R:R:L62	2.44	Yes	Yes	6	7	5
501	R:R:L62	R:R:L83	5.54	Yes	No	6	5	9
502	R:R:L62	R:R:L86	2.77	Yes	Yes	6	5	8
503	R:R:D63	R:R:S65	8.83	Yes	Yes	3	9	9
504	R:R:D63	R:R:Q87	5.22	Yes	No	0	9	8
505	R:R:I64	R:R:N67	7.08	Yes	Yes	6	6	9
506	R:R:I64	R:R:L88	2.85	Yes	Yes	0	6	9
507	R:R:M66	R:R:S65	9.2	Yes	Yes	3	9	9
508	R:R:A89	R:R:S65	1.71	No	Yes	0	9	9
509	R:R:I69	R:R:N67	4.25	No	Yes	6	7	9
510	R:R:N67	R:R:N91	6.81	Yes	Yes	6	9	9
511	R:R:I69	R:R:N91	8.5	No	Yes	6	7	9
512	R:R:Q71	R:R:T70	2.83	No	No	0	4	8
513	R:R:F95	R:R:Q71	3.51	No	No	0	3	4
514	R:R:L72	R:R:L88	2.77	No	Yes	0	7	9
515	R:R:L72	R:R:L93	2.77	No	No	1	7	9
516	R:R:I96	R:R:L72	4.28	Yes	No	1	9	7
517	R:R:A76	R:R:P73	1.87	No	No	0	4	5
518	R:R:D75	R:R:E74	7.8	No	No	0	4	5
519	R:R:E74	R:R:H97	19.69	No	No	26	5	8
520	R:R:E74	R:R:K99	8.1	No	No	26	5	3
521	R:R:D75	R:R:K78	4.15	No	No	0	4	4
522	R:R:A76	R:R:F77	2.77	No	Yes	6	4	7
523	R:R:F77	R:R:F80	2.14	Yes	Yes	6	7	7
524	R:R:F77	R:R:L83	2.44	Yes	No	6	7	9
525	R:R:F77	R:R:L86	7.31	Yes	Yes	6	7	8
526	R:R:F77	R:R:L104	6.09	Yes	No	0	7	9
527	R:R:K78	R:R:N79	8.39	No	No	0	4	4
528	R:R:F80	R:R:N79	2.42	Yes	No	0	7	4
529	R:R:F80	R:R:L83	4.87	Yes	No	6	7	9
530	R:R:F82	R:R:P81	7.22	No	No	0	5	5
531	R:R:E106	R:R:F82	12.83	No	No	0	7	5
532	R:R:E84	R:R:K108	9.45	No	No	0	6	8
533	R:R:E85	R:R:V109	4.28	No	No	0	8	8
534	R:R:L86	R:R:L88	5.54	Yes	Yes	0	8	9
535	R:R:L110	R:R:L86	4.15	Yes	Yes	0	9	8
536	R:R:Q87	R:R:T111	4.25	No	No	0	8	9
537	R:R:L88	R:R:N91	2.75	Yes	Yes	0	9	9
538	R:R:L112	R:R:L88	4.15	Yes	Yes	0	9	9
539	R:R:A89	R:R:Q113	4.55	No	Yes	0	9	9
540	R:R:G90	R:R:N114	1.7	No	Yes	3	9	9
541	R:R:G90	R:R:N115	1.7	No	Yes	0	9	9
542	R:R:N115	R:R:N91	2.72	Yes	Yes	0	9	9
543	R:R:I96	R:R:L93	2.85	Yes	No	1	9	9
544	R:R:L93	R:R:N115	9.61	No	Yes	0	9	9
545	R:R:Q116	R:R:S94	2.89	No	No	0	6	5
546	R:R:I96	R:R:L117	4.28	Yes	Yes	1	9	8
547	R:R:I96	R:R:P121	3.39	Yes	Yes	1	9	8
548	R:R:A124	R:R:I96	3.25	No	Yes	1	8	9
549	R:R:H97	R:R:P98	12.2	No	No	0	8	4
550	R:R:H97	R:R:K99	5.24	No	No	26	8	3
551	R:R:K99	R:R:S102	6.12	No	No	0	3	5
552	R:R:L101	R:R:L128	2.77	No	No	0	7	9
553	R:R:G103	R:R:K105	1.74	No	No	0	8	3
554	R:R:L104	R:R:L107	2.77	No	No	0	9	9
555	R:R:L107	R:R:L110	2.77	No	Yes	0	9	9
556	R:R:K108	R:R:V109	3.04	No	No	0	8	8
557	R:R:K108	R:R:Q132	16.27	No	No	0	8	8
558	R:R:S133	R:R:V109	6.46	No	No	0	9	8
559	R:R:L110	R:R:L112	9.69	Yes	Yes	0	9	9
560	R:R:L110	R:R:L134	4.15	Yes	Yes	0	9	9
561	R:R:Q113	R:R:T111	7.09	Yes	No	3	9	9
562	R:R:R135	R:R:T111	11.64	Yes	No	3	9	9
563	R:R:L112	R:R:N115	2.75	Yes	Yes	0	9	9
564	R:R:L112	R:R:L117	2.77	Yes	Yes	0	9	8
565	R:R:L112	R:R:L136	4.15	Yes	Yes	0	9	9
566	R:R:Q113	R:R:R135	10.51	Yes	Yes	3	9	9
567	R:R:D137	R:R:Q113	7.83	Yes	Yes	3	9	9
568	R:R:A138	R:R:N114	3.13	No	Yes	3	9	9
569	R:R:N115	R:R:N139	4.09	Yes	Yes	0	9	9
570	R:R:L117	R:R:P121	3.28	Yes	Yes	1	8	8
571	R:R:L117	R:R:N139	10.98	Yes	Yes	1	8	9
572	R:R:S143	R:R:T119	3.2	No	No	0	3	5
573	R:R:P145	R:R:T119	3.5	Yes	No	0	9	5
574	R:R:P121	R:R:V120	3.53	Yes	Yes	1	8	7
575	R:R:I141	R:R:V120	3.07	Yes	Yes	1	9	7
576	R:R:V120	R:R:V144	6.41	Yes	Yes	1	7	9
577	R:R:P145	R:R:V120	1.77	Yes	Yes	1	9	7
578	R:R:F149	R:R:V120	2.62	Yes	Yes	1	9	7
579	R:R:A124	R:R:P121	1.87	No	Yes	1	8	8
580	R:R:E123	R:R:S122	2.87	No	No	0	5	5
581	R:R:P145	R:R:S122	7.13	Yes	No	0	9	5
582	R:R:D147	R:R:S122	2.94	No	No	0	3	5
583	R:R:E123	R:R:R126	5.82	No	No	0	5	4
584	R:R:F149	R:R:I125	2.51	Yes	No	0	9	5
585	R:R:I125	R:R:L152	2.85	No	No	0	5	8
586	R:R:E150	R:R:R126	10.47	No	No	0	4	4
587	R:R:L131	R:R:L152	4.15	No	No	0	9	8
588	R:R:L131	R:R:L155	2.77	No	No	0	9	9
589	R:R:Q132	R:R:R156	17.52	No	Yes	0	8	9
590	R:R:H157	R:R:S133	8.37	Yes	No	0	9	9
591	R:R:L134	R:R:L136	5.54	Yes	Yes	1	9	9
592	R:R:F149	R:R:L134	2.44	Yes	Yes	1	9	9
593	R:R:L134	R:R:L158	4.15	Yes	Yes	1	9	9
594	R:R:D137	R:R:R135	4.76	Yes	Yes	3	9	9
595	R:R:R135	R:R:W159	23.99	Yes	Yes	3	9	9
596	R:R:L136	R:R:N139	2.75	Yes	Yes	1	9	9
597	R:R:I141	R:R:L136	2.85	Yes	Yes	1	9	9
598	R:R:L136	R:R:L160	4.15	Yes	Yes	0	9	9
599	R:R:A138	R:R:D137	3.09	No	Yes	3	9	9
600	R:R:D137	R:R:W159	5.58	Yes	Yes	3	9	9
601	R:R:D137	R:R:D161	11.98	Yes	Yes	3	9	9
602	R:R:I141	R:R:N139	4.25	Yes	Yes	1	9	9
603	R:R:I141	R:R:N163	14.16	Yes	No	0	9	9
604	R:R:S143	R:R:T142	3.2	No	No	0	3	6
605	R:R:P145	R:R:V144	3.53	Yes	Yes	1	9	9
606	R:R:S148	R:R:V144	3.23	Yes	Yes	1	8	9
607	R:R:P169	R:R:V144	10.6	No	Yes	1	9	9
608	R:R:P172	R:R:V144	5.3	Yes	Yes	1	9	9
609	R:R:P145	R:R:S148	3.56	Yes	Yes	1	9	8
610	R:R:F149	R:R:S148	2.64	Yes	Yes	1	9	8
611	R:R:P172	R:R:S148	3.56	Yes	Yes	1	9	8
612	R:R:F149	R:R:L158	3.65	Yes	Yes	1	9	9
613	R:R:F149	R:R:L173	2.44	Yes	No	0	9	9
614	R:R:F149	R:R:L176	7.31	Yes	No	0	9	9
615	R:R:L155	R:R:L176	5.54	No	No	0	9	9
616	R:R:L155	R:R:L179	2.77	No	Yes	0	9	9
617	R:R:H157	R:R:R156	4.51	Yes	Yes	0	9	9
618	R:R:Q180	R:R:R156	9.35	Yes	Yes	0	9	9
619	R:R:H157	R:R:W159	2.12	Yes	Yes	3	9	9
620	R:R:L158	R:R:L160	6.92	Yes	Yes	0	9	9
621	R:R:L158	R:R:L182	4.15	Yes	Yes	1	9	8
622	R:R:T183	R:R:W159	7.28	Yes	Yes	3	9	9
623	R:R:L160	R:R:N163	2.75	Yes	No	0	9	9
624	R:R:L160	R:R:L184	4.15	Yes	Yes	0	9	9
625	R:R:D161	R:R:D162	3.99	Yes	Yes	3	9	9
626	R:R:D161	R:R:T183	4.34	Yes	Yes	3	9	9
627	R:R:D162	R:R:L186	9.5	Yes	No	3	9	9
628	R:R:N163	R:R:N187	4.09	No	No	0	9	9
629	R:R:K188	R:R:S164	4.59	No	No	0	4	5
630	R:R:L165	R:R:N187	12.36	No	No	0	9	9
631	R:R:I189	R:R:L165	2.85	Yes	No	0	9	9
632	R:R:E167	R:R:T166	5.64	No	No	0	6	6
633	R:R:P169	R:R:V168	3.53	No	Yes	1	9	8
634	R:R:I189	R:R:V168	6.14	Yes	Yes	0	9	8
635	R:R:I192	R:R:V168	3.07	Yes	Yes	1	8	8
636	R:R:F197	R:R:V168	2.62	Yes	Yes	1	9	8
637	R:R:P169	R:R:P172	5.84	No	Yes	1	9	9
638	R:R:P193	R:R:V170	1.77	No	No	1	9	6
639	R:R:A196	R:R:V170	1.7	No	No	1	9	6
640	R:R:H171	R:R:P172	4.58	No	Yes	0	1	9
641	R:R:H171	R:R:S174	4.18	No	No	0	1	5
642	R:R:F197	R:R:L173	2.44	Yes	No	0	9	9
643	R:R:N175	R:R:S174	4.47	No	No	0	4	5
644	R:R:P177	R:R:T178	1.75	No	No	0	4	5
645	R:R:L179	R:R:L182	5.54	Yes	Yes	1	9	8
646	R:R:L179	R:R:L200	4.15	Yes	No	1	9	9
647	R:R:L179	R:R:L203	4.15	Yes	Yes	1	9	9
648	R:R:Q180	R:R:S202	2.89	Yes	No	0	9	8
649	R:R:Q180	R:R:V204	2.87	Yes	Yes	3	9	9
650	R:R:L182	R:R:L184	5.54	Yes	Yes	0	8	9
651	R:R:F197	R:R:L182	2.44	Yes	Yes	1	9	8
652	R:R:L182	R:R:L206	4.15	Yes	Yes	1	8	9
653	R:R:H207	R:R:T183	5.48	Yes	Yes	3	9	9
654	R:R:I189	R:R:L184	2.85	Yes	Yes	0	9	9
655	R:R:L184	R:R:L208	4.15	Yes	Yes	0	9	9
656	R:R:A185	R:R:H209	7.32	No	Yes	0	9	9
657	R:R:L186	R:R:N210	10.98	No	Yes	3	9	9
658	R:R:N187	R:R:N211	2.72	No	Yes	0	9	9
659	R:R:I189	R:R:N211	12.74	Yes	Yes	0	9	9
660	R:R:S190	R:R:S191	3.26	No	No	0	3	4
661	R:R:I192	R:R:P193	3.39	Yes	No	1	8	9
662	R:R:F197	R:R:I192	2.51	Yes	Yes	1	9	8
663	R:R:I192	R:R:I213	2.94	Yes	Yes	1	8	9
664	R:R:I192	R:R:L216	4.28	Yes	Yes	1	8	6
665	R:R:C220	R:R:I192	3.27	Yes	Yes	1	5	8
666	R:R:F221	R:R:I192	2.51	Yes	Yes	1	9	8
667	R:R:A196	R:R:P193	1.87	No	No	1	9	9
668	R:R:D194	R:R:F195	2.39	No	Yes	27	8	2
669	R:R:D194	R:R:S217	10.31	No	No	0	8	6
670	R:R:D194	R:R:H219	5.04	No	No	27	8	5
671	R:R:F195	R:R:T198	6.49	Yes	No	0	2	4
672	R:R:F195	R:R:H219	5.66	Yes	No	27	2	5
673	R:R:D222	R:R:F195	13.14	No	Yes	0	4	2
674	R:R:A196	R:R:F197	5.55	No	Yes	1	9	9
675	R:R:F197	R:R:L200	4.87	Yes	No	1	9	9
676	R:R:F197	R:R:L206	2.44	Yes	Yes	1	9	9
677	R:R:F197	R:R:F221	4.29	Yes	Yes	1	9	9
678	R:R:F197	R:R:L224	7.31	Yes	Yes	1	9	9
679	R:R:N199	R:R:T198	2.92	No	No	0	9	4
680	R:R:L200	R:R:L203	5.54	No	Yes	1	9	9
681	R:R:L203	R:R:L206	2.77	Yes	Yes	1	9	9
682	R:R:L203	R:R:L224	4.15	Yes	Yes	1	9	9
683	R:R:L203	R:R:L227	4.15	Yes	No	1	9	9
684	R:R:V204	R:R:V205	3.21	Yes	Yes	3	9	9
685	R:R:E228	R:R:V204	5.7	No	Yes	0	9	9
686	R:R:H207	R:R:V205	6.92	Yes	Yes	3	9	9
687	R:R:T229	R:R:V205	7.93	No	Yes	0	9	9
688	R:R:L206	R:R:L208	9.69	Yes	Yes	0	9	9
689	R:R:F221	R:R:L206	2.44	Yes	Yes	1	9	9
690	R:R:L206	R:R:L230	4.15	Yes	Yes	1	9	9
691	R:R:D231	R:R:H207	13.87	No	Yes	3	9	9
692	R:R:I213	R:R:L208	2.85	Yes	Yes	0	9	9
693	R:R:L208	R:R:L232	4.15	Yes	Yes	0	9	9
694	R:R:H209	R:R:N210	8.93	Yes	Yes	3	9	9
695	R:R:D231	R:R:H209	2.52	No	Yes	3	9	9
696	R:R:H209	R:R:N233	5.1	Yes	Yes	3	9	9
697	R:R:N210	R:R:Y234	9.3	Yes	Yes	3	9	6
698	R:R:I213	R:R:N211	8.5	Yes	Yes	1	9	9
699	R:R:N211	R:R:N235	2.72	Yes	Yes	1	9	9
700	R:R:I213	R:R:L216	2.85	Yes	Yes	1	9	6
701	R:R:I213	R:R:N235	18.41	Yes	Yes	1	9	9
702	R:R:C220	R:R:L216	3.17	Yes	Yes	1	5	6
703	R:R:L216	R:R:L237	2.77	Yes	Yes	1	6	8
704	R:R:L216	R:R:P241	4.93	Yes	No	1	6	9
705	R:R:C220	R:R:S217	5.16	Yes	No	0	5	6
706	R:R:C220	R:R:F221	8.38	Yes	Yes	1	5	9
707	R:R:A243	R:R:C220	1.81	No	Yes	1	8	5
708	R:R:F221	R:R:L224	4.87	Yes	Yes	1	9	9
709	R:R:F221	R:R:L230	4.87	Yes	Yes	1	9	9
710	R:R:F221	R:R:L232	2.44	Yes	Yes	1	9	9
711	R:R:A243	R:R:F221	4.16	No	Yes	1	8	9
712	R:R:D222	R:R:G223	3.35	No	No	0	4	9
713	R:R:L224	R:R:L227	2.77	Yes	No	1	9	9
714	R:R:L227	R:R:L247	5.54	No	No	0	9	9
715	R:R:E228	R:R:K251	18.9	No	No	0	9	9
716	R:R:E252	R:R:T229	5.64	Yes	No	0	9	9
717	R:R:L230	R:R:L232	6.92	Yes	Yes	1	9	9
718	R:R:L230	R:R:L253	4.15	Yes	Yes	0	9	9
719	R:R:D231	R:R:N233	4.04	No	Yes	3	9	9
720	R:R:L232	R:R:N235	6.87	Yes	Yes	1	9	9
721	R:R:N233	R:R:Y234	3.49	Yes	Yes	3	9	6
722	R:R:G254	R:R:N233	1.7	No	Yes	0	7	9
723	R:R:H256	R:R:N233	16.58	Yes	Yes	3	9	9
724	R:R:H256	R:R:Y234	5.44	Yes	Yes	3	9	6
725	R:R:S257	R:R:Y234	13.99	No	Yes	3	8	6
726	R:R:N235	R:R:N258	2.72	Yes	Yes	1	9	9
727	R:R:L237	R:R:P241	3.28	Yes	No	1	8	9
728	R:R:L237	R:R:N258	12.36	Yes	Yes	1	8	9
729	R:R:I260	R:R:L237	5.71	Yes	Yes	1	9	8
730	R:R:G238	R:R:S259	1.86	No	No	0	2	6
731	R:R:F240	R:R:P241	5.78	Yes	No	1	9	9
732	R:R:F240	R:R:F255	7.5	Yes	Yes	1	9	9
733	R:R:A267	R:R:F240	4.16	No	Yes	1	9	9
734	R:R:F240	R:R:F268	2.14	Yes	Yes	1	9	9
735	R:R:I244	R:R:L253	2.85	No	Yes	0	8	9
736	R:R:I244	R:R:N271	5.66	No	Yes	0	8	9
737	R:R:L247	R:R:L250	2.77	No	No	0	9	9
738	R:R:P248	R:R:S249	1.78	No	No	0	4	6
739	R:R:L250	R:R:L253	5.54	No	Yes	0	9	9
740	R:R:L250	R:R:N271	2.75	No	Yes	0	9	9
741	R:R:E252	R:R:T276	4.23	Yes	Yes	3	9	8
742	R:R:E252	R:R:H278	2.46	Yes	Yes	3	9	8
743	R:R:F255	R:R:L253	6.09	Yes	Yes	0	9	9
744	R:R:G254	R:R:H278	3.18	No	Yes	0	7	8
745	R:R:F255	R:R:N258	4.83	Yes	Yes	1	9	9
746	R:R:F255	R:R:I260	5.02	Yes	Yes	1	9	9
747	R:R:F255	R:R:I277	2.51	Yes	Yes	1	9	8
748	R:R:F255	R:R:L279	4.87	Yes	Yes	1	9	8
749	R:R:F255	R:R:N282	2.42	Yes	Yes	1	9	9
750	R:R:H256	R:R:S257	4.18	Yes	No	3	9	8
751	R:R:H256	R:R:H278	3.58	Yes	Yes	3	9	8
752	R:R:H256	R:R:Y280	32.67	Yes	No	0	9	7
753	R:R:I260	R:R:N258	8.5	Yes	Yes	1	9	9
754	R:R:I260	R:R:N282	2.83	Yes	Yes	1	9	9
755	R:R:S261	R:R:V262	4.85	No	No	0	4	5
756	R:R:S261	R:R:S285	3.26	No	No	0	4	8
757	R:R:P264	R:R:V262	1.77	No	No	0	9	5
758	R:R:I263	R:R:L284	5.71	No	No	0	9	8
759	R:R:I263	R:R:V287	6.14	No	No	0	9	9
760	R:R:D265	R:R:G288	3.35	No	No	0	8	9
761	R:R:D265	R:R:S290	8.83	No	No	0	8	8
762	R:R:D269	R:R:G266	5.03	No	No	0	3	4
763	R:R:A267	R:R:F268	2.77	No	Yes	1	9	9
764	R:R:F268	R:R:N271	3.62	Yes	Yes	1	9	9
765	R:R:F268	R:R:L274	3.65	Yes	No	1	9	9
766	R:R:F268	R:R:I277	7.54	Yes	Yes	1	9	8
767	R:R:F268	R:R:F292	5.36	Yes	Yes	1	9	9
768	R:R:G270	R:R:N271	3.39	No	Yes	0	6	9
769	R:R:L274	R:R:N271	6.87	No	Yes	1	9	9
770	R:R:I277	R:R:L274	4.28	Yes	No	1	8	9
771	R:R:R275	R:R:T276	2.59	No	Yes	0	5	8
772	R:R:D297	R:R:R275	9.53	No	No	0	5	5
773	R:R:H278	R:R:T276	4.11	Yes	Yes	3	8	8
774	R:R:H299	R:R:T276	2.74	No	Yes	0	7	8
775	R:R:I277	R:R:L279	2.85	Yes	Yes	1	8	8
776	R:R:F292	R:R:I277	2.51	Yes	Yes	1	9	8
777	R:R:L279	R:R:N282	4.12	Yes	Yes	1	8	9
778	R:R:F292	R:R:L279	2.44	Yes	Yes	1	9	8
779	R:R:D281	R:R:Y280	11.49	No	No	0	8	7
780	R:R:L284	R:R:N282	6.87	No	Yes	0	8	9
781	R:R:F286	R:R:G288	6.02	No	No	0	4	9
782	R:R:G288	R:R:V287	1.84	No	No	0	9	9
783	R:R:V287	R:R:V309	3.21	No	No	0	9	7
784	R:R:N289	R:R:Q311	19.81	No	No	0	4	4
785	R:R:N314	R:R:S290	2.98	No	No	0	7	8
786	R:R:A291	R:R:F292	5.55	No	Yes	0	9	9
787	R:R:F292	R:R:L295	2.44	Yes	No	0	9	9
788	R:R:F292	R:R:L301	12.18	Yes	No	1	9	9
789	R:R:F292	R:R:I303	2.51	Yes	No	1	9	8
790	R:R:H293	R:R:N294	7.65	No	No	0	7	6
791	R:R:H293	R:R:N314	8.93	No	No	28	7	7
792	R:R:H293	R:R:T316	8.21	No	No	28	7	5
793	R:R:G317	R:R:N294	1.7	No	No	0	7	6
794	R:R:L295	R:R:L298	2.77	No	No	0	9	9
795	R:R:L295	R:R:T318	2.95	No	No	0	9	8
796	R:R:D297	R:R:S296	2.94	No	No	0	5	9
797	R:R:L298	R:R:L321	2.77	No	No	0	9	8
798	R:R:H299	R:R:S300	4.18	No	No	0	7	9
799	R:R:E322	R:R:H299	2.46	No	No	0	8	7
800	R:R:S300	R:R:S323	3.26	No	No	0	9	7
801	R:R:I303	R:R:L301	7.14	No	No	1	8	9
802	R:R:L301	R:R:L324	4.15	No	Yes	1	9	9
803	R:R:R304	R:R:V302	6.54	Yes	No	15	8	7
804	R:R:T325	R:R:V302	11.11	No	No	15	8	7
805	R:R:I303	R:R:L326	4.28	No	Yes	1	8	7
806	R:R:R304	R:R:T325	3.88	Yes	No	15	8	8
807	R:R:R304	R:R:T327	12.94	Yes	Yes	15	8	9
808	R:R:A306	R:R:V309	3.39	No	No	0	9	7
809	R:R:T329	R:R:V309	6.35	No	No	0	8	7
810	R:R:K330	R:R:Q310	8.14	No	No	0	5	5
811	R:R:F312	R:R:P313	7.22	Yes	No	1	8	9
812	R:R:F312	R:R:L324	2.44	Yes	Yes	1	8	9
813	R:R:F312	R:R:L326	2.44	Yes	Yes	1	8	7
814	R:R:F312	R:R:I331	2.51	Yes	No	1	8	8
815	R:R:F312	R:R:P335	15.89	Yes	No	0	8	8
816	R:R:F312	R:R:L338	2.44	Yes	No	0	8	5
817	R:R:F312	R:R:L350	2.44	Yes	Yes	1	8	9
818	R:R:L326	R:R:P313	3.28	Yes	No	1	7	9
819	R:R:N314	R:R:T316	8.77	No	No	28	7	5
820	R:R:L321	R:R:T318	4.42	No	No	0	8	8
821	R:R:H320	R:R:V319	4.15	No	No	0	7	4
822	R:R:E341	R:R:V319	4.28	Yes	No	0	5	4
823	R:R:L321	R:R:Q342	3.99	No	No	0	8	8
824	R:R:E322	R:R:M344	5.41	No	No	0	8	4
825	R:R:S323	R:R:T347	3.2	No	No	0	7	6
826	R:R:L324	R:R:L326	5.54	Yes	Yes	1	9	7
827	R:R:L324	R:R:L348	2.77	Yes	Yes	1	9	9
828	R:R:D349	R:R:T325	7.23	Yes	No	15	8	8
829	R:R:L326	R:R:L350	4.15	Yes	Yes	1	7	9
830	R:R:G328	R:R:T327	3.64	No	Yes	0	7	9
831	R:R:D349	R:R:T327	4.34	Yes	Yes	15	8	9
832	R:R:S351	R:R:T327	4.8	Yes	Yes	15	9	9
833	R:R:T327	R:R:Y352	4.99	Yes	No	15	9	7
834	R:R:I331	R:R:T329	10.64	No	No	1	8	8
835	R:R:N353	R:R:T329	8.77	Yes	No	1	9	8
836	R:R:I331	R:R:N353	11.33	No	Yes	1	8	9
837	R:R:N354	R:R:S332	2.98	No	No	0	3	4
838	R:R:R356	R:R:S332	6.59	No	No	0	3	4
839	R:R:I334	R:R:P335	3.39	Yes	No	0	7	8
840	R:R:I334	R:R:L338	2.85	Yes	No	0	7	5
841	R:R:I334	R:R:L350	2.85	Yes	Yes	1	7	9
842	R:R:I334	R:R:I355	2.94	Yes	Yes	1	7	8
843	R:R:I334	R:R:P359	5.08	Yes	Yes	0	7	9
844	R:R:N337	R:R:P335	3.26	No	No	0	3	8
845	R:R:N336	R:R:P359	4.89	No	Yes	0	1	9
846	R:R:E341	R:R:N337	5.26	Yes	No	0	5	3
847	R:R:L338	R:R:L348	2.77	No	Yes	0	5	9
848	R:R:C339	R:R:G363	1.96	No	Yes	1	9	4
849	R:R:C339	R:R:C364	7.28	No	No	1	9	9
850	R:R:E341	R:R:Q340	2.55	Yes	No	0	5	4
851	R:R:E341	R:R:Q342	8.92	Yes	No	0	5	8
852	R:R:R346	R:R:T347	2.59	No	No	0	7	6
853	R:R:E368	R:R:R346	5.82	No	No	0	7	7
854	R:R:L348	R:R:L350	6.92	Yes	Yes	1	9	9
855	R:R:F361	R:R:L348	2.44	Yes	Yes	1	6	9
856	R:R:D349	R:R:S351	4.42	Yes	Yes	15	8	9
857	R:R:D349	R:R:S371	2.94	Yes	No	0	8	6
858	R:R:L350	R:R:N353	2.75	Yes	Yes	1	9	9
859	R:R:I355	R:R:L350	2.85	Yes	Yes	1	8	9
860	R:R:S351	R:R:Y352	6.36	Yes	No	15	9	7
861	R:R:Q373	R:R:S351	2.89	Yes	Yes	0	8	9
862	R:R:R374	R:R:Y352	18.52	No	No	0	8	7
863	R:R:I355	R:R:N353	2.83	Yes	Yes	1	8	9
864	R:R:N354	R:R:Q376	6.6	No	No	0	3	4
865	R:R:I355	R:R:N375	9.91	Yes	No	1	8	9
866	R:R:Q376	R:R:R356	5.84	No	No	0	4	3
867	R:R:D357	R:R:Y378	2.3	No	No	0	3	1
868	R:R:L358	R:R:P359	3.28	Yes	Yes	0	8	9
869	R:R:L358	R:R:L372	4.15	Yes	No	0	8	8
870	R:R:I377	R:R:L358	2.85	Yes	Yes	0	7	8
871	R:R:L358	R:R:T384	2.95	Yes	No	0	8	8
872	R:R:F361	R:R:P359	2.89	Yes	Yes	0	6	9
873	R:R:F361	R:R:L367	2.44	Yes	Yes	1	6	7
874	R:R:F361	R:R:I370	2.51	Yes	Yes	1	6	7
875	R:R:F361	R:R:L388	3.65	Yes	Yes	1	6	8
876	R:R:G363	R:R:N362	1.7	Yes	No	0	4	4
877	R:R:C364	R:R:G363	1.96	No	Yes	1	9	4
878	R:R:G363	R:R:H365	3.18	Yes	No	0	4	3
879	R:R:C364	R:R:L367	3.17	No	Yes	1	9	7
880	R:R:I370	R:R:L367	7.14	Yes	Yes	1	7	7
881	R:R:L367	R:R:L388	5.54	Yes	Yes	1	7	8
882	R:R:E368	R:R:E369	8.88	No	No	0	7	7
883	R:R:E368	R:R:R392	8.14	No	Yes	0	7	6
884	R:R:E369	R:R:I393	4.1	No	No	0	7	4
885	R:R:I370	R:R:L372	4.28	Yes	No	0	7	8
886	R:R:I370	R:R:L391	5.71	Yes	Yes	0	7	9
887	R:R:I370	R:R:L394	2.85	Yes	Yes	0	7	7
888	R:R:Q373	R:R:S371	2.89	Yes	No	0	8	6
889	R:R:L372	R:R:L396	2.77	No	No	0	8	9
890	R:R:Q373	R:R:R374	11.68	Yes	No	0	8	8
891	R:R:Q373	R:R:S397	5.78	Yes	No	0	8	8
892	R:R:R374	R:R:R398	8.53	No	No	0	8	5
893	R:R:I377	R:R:N375	2.83	Yes	No	1	7	9
894	R:R:N375	R:R:N399	5.45	No	No	1	9	9
895	R:R:I377	R:R:N399	14.16	Yes	No	1	7	9
896	R:R:I377	R:R:I401	5.89	Yes	Yes	1	7	8
897	R:R:Q379	R:R:Y378	5.64	No	No	29	5	1
898	R:R:K381	R:R:Y378	4.78	No	No	29	1	1
899	R:R:K381	R:R:Q379	2.71	No	No	29	1	5
900	R:R:E403	R:R:Q379	16.57	No	No	0	2	5
901	R:R:I380	R:R:I401	4.42	No	Yes	1	7	8
902	R:R:I380	R:R:I404	5.89	No	Yes	1	7	7
903	R:R:K381	R:R:T384	4.5	No	No	0	1	8
904	R:R:E382	R:R:H405	25.85	No	No	0	4	6
905	R:R:G383	R:R:Q386	3.29	No	No	0	4	4
906	R:R:F385	R:R:T384	5.19	No	No	0	9	8
907	R:R:F385	R:R:L391	2.44	No	Yes	0	9	9
908	R:R:F385	R:R:L394	9.74	No	Yes	0	9	7
909	R:R:Q386	R:R:T411	12.76	No	No	0	4	4
910	R:R:G387	R:R:L388	1.71	No	Yes	0	5	8
911	R:R:G387	R:R:T411	1.82	No	No	0	5	4
912	R:R:L388	R:R:L391	5.54	Yes	Yes	0	8	9
913	R:R:L391	R:R:L412	5.54	Yes	No	0	9	8
914	R:R:I393	R:R:R392	6.26	No	Yes	0	4	6
915	R:R:R392	R:R:T416	2.59	Yes	No	0	6	4
916	R:R:R392	T:T:T75	16.82	Yes	No	0	6	8
917	R:R:L394	R:R:L396	6.92	Yes	No	0	7	9
918	R:R:L394	R:R:L418	4.15	Yes	Yes	0	7	9
919	R:R:D395	R:R:D419	2.66	No	Yes	0	9	9
920	R:R:R398	R:R:S397	6.59	No	No	0	5	8
921	R:R:D419	R:R:S397	2.94	Yes	No	0	9	8
922	R:R:F422	R:R:R398	4.28	No	No	0	4	5
923	R:R:I401	R:R:N399	2.83	Yes	No	1	8	9
924	R:R:I401	R:R:I404	2.94	Yes	Yes	1	8	7
925	R:R:I401	R:R:N423	4.25	Yes	No	1	8	9
926	R:R:E403	R:R:H402	11.08	No	No	0	2	3
927	R:R:I404	R:R:L425	4.28	Yes	Yes	1	7	9
928	R:R:I404	R:R:P429	5.08	Yes	No	0	7	9
929	R:R:H405	R:R:S406	6.97	No	No	30	6	3
930	R:R:H405	R:R:R407	2.26	No	No	30	6	4
931	R:R:R407	R:R:S406	3.95	No	No	30	4	3
932	R:R:A410	R:R:R407	4.15	No	No	0	3	4
933	R:R:A408	R:R:F409	2.77	No	No	0	8	8
934	R:R:F409	R:R:P429	2.89	No	No	0	8	9
935	R:R:F409	R:R:L433	4.87	No	Yes	0	8	9
936	R:R:I415	R:R:L412	7.14	No	No	0	7	8
937	R:R:G413	R:R:P414	4.06	No	No	0	3	5
938	R:R:I415	R:R:L418	2.85	No	Yes	1	7	9
939	R:R:I415	R:R:L436	5.71	No	No	1	7	8
940	R:R:N417	R:R:T416	4.39	No	No	0	7	4
941	R:R:N437	R:R:T416	4.39	Yes	No	0	5	4
942	R:R:N417	R:R:Q438	9.24	No	Yes	2	7	9
943	R:R:L418	R:R:L436	5.54	Yes	No	1	9	8
944	R:R:L418	R:R:L439	4.15	Yes	Yes	1	9	8
945	R:R:D419	R:R:S421	5.89	Yes	Yes	0	9	7
946	R:R:D419	R:R:K440	22.12	Yes	No	0	9	8
947	R:R:N423	R:R:V420	8.87	No	Yes	1	9	6
948	R:R:L425	R:R:V420	4.47	Yes	Yes	1	9	6
949	R:R:L441	R:R:V420	2.98	Yes	Yes	1	8	6
950	R:R:N444	R:R:V420	2.96	Yes	Yes	1	9	6
951	R:R:F422	R:R:S421	13.21	No	Yes	19	4	7
952	R:R:S421	R:R:V442	6.46	Yes	No	19	7	4
953	R:R:G443	R:R:S421	1.86	No	Yes	19	8	7
954	R:R:F422	R:R:G443	6.02	No	No	19	4	8
955	R:R:N423	R:R:N444	4.09	No	Yes	1	9	9
956	R:R:E424	R:R:K446	10.8	No	No	0	3	3
957	R:R:L425	R:R:N444	13.73	Yes	Yes	1	9	9
958	R:R:L425	R:R:L447	2.77	Yes	Yes	1	9	7
959	R:R:E449	R:R:S427	8.62	No	No	0	4	4
960	R:R:F428	R:R:P429	7.22	Yes	No	0	4	9
961	R:R:F428	R:R:L433	3.65	Yes	Yes	1	4	9
962	R:R:F428	R:R:L439	3.65	Yes	Yes	1	4	8
963	R:R:F428	R:R:L441	3.65	Yes	Yes	1	4	8
964	R:R:E449	R:R:F428	2.33	No	Yes	0	4	4
965	R:R:F428	R:R:L451	2.44	Yes	No	0	4	7
966	R:R:F428	R:R:F456	3.22	Yes	Yes	1	4	5
967	R:R:D455	R:R:T430	11.56	Yes	No	0	4	5
968	R:R:E431	R:R:G432	4.91	No	No	0	3	8
969	R:R:G432	R:R:N434	1.7	No	No	0	8	3
970	R:R:L433	R:R:L436	8.3	Yes	No	1	9	8
971	R:R:F456	R:R:L433	7.31	Yes	Yes	1	5	9
972	R:R:G435	R:R:N434	3.39	No	No	0	4	3
973	R:R:G435	R:R:N458	1.7	No	No	0	4	4
974	R:R:N437	R:R:R460	4.82	Yes	Yes	2	5	9
975	R:R:N437	T:T:Y77	4.65	Yes	No	0	5	6
976	R:R:N437	T:T:T78	4.39	Yes	No	2	5	9
977	R:R:Q438	R:R:R460	2.34	Yes	Yes	2	9	9
978	R:R:Q438	R:R:S461	10.11	Yes	No	2	9	6
979	R:R:L439	R:R:L441	6.92	Yes	Yes	1	8	8
980	R:R:F456	R:R:L439	3.65	Yes	Yes	1	5	8
981	R:R:L439	R:R:L462	4.15	Yes	Yes	0	8	7
982	R:R:K440	R:R:S463	7.65	No	No	0	8	8
983	R:R:L441	R:R:N444	4.12	Yes	Yes	1	8	9
984	R:R:G443	R:R:V442	1.84	No	No	19	8	4
985	R:R:S463	R:R:V442	3.23	No	No	0	8	4
986	R:R:L447	R:R:N444	2.75	Yes	Yes	1	7	9
987	R:R:F445	R:R:Y466	11.35	No	No	0	1	6
988	R:R:E449	R:R:L447	5.3	No	Yes	0	4	7
989	R:R:L447	R:R:P465	3.28	Yes	No	1	7	9
990	R:R:I610	R:R:K448	2.91	Yes	No	1	7	7
991	R:R:K448	R:R:T614	7.51	No	No	1	7	4
992	R:R:F473	R:R:L451	2.44	Yes	No	0	8	7
993	R:R:A453	R:R:A472	1.79	No	No	0	4	7
994	R:R:A453	R:R:F473	5.55	No	Yes	0	4	8
995	R:R:D455	R:R:F456	2.39	Yes	Yes	0	4	5
996	R:R:F456	R:R:L459	6.09	Yes	No	0	5	7
997	R:R:F456	R:R:F473	3.22	Yes	Yes	0	5	8
998	R:R:N458	R:R:V457	7.39	No	No	0	4	4
999	R:R:N458	T:T:G80	1.7	No	Yes	0	4	7
1000	R:R:L459	R:R:L462	6.92	No	Yes	0	7	7
1001	R:R:R460	R:R:S461	2.64	Yes	No	2	9	6
1002	R:R:R460	T:T:T78	7.76	Yes	No	2	9	9
1003	R:R:L462	R:R:V464	4.47	Yes	Yes	0	7	7
1004	R:R:F473	R:R:L462	7.31	Yes	Yes	0	8	7
1005	R:R:S463	R:R:T523	7.99	No	No	0	8	6
1006	R:R:P465	R:R:V464	3.53	No	Yes	1	9	7
1007	R:R:Q469	R:R:V464	7.16	Yes	Yes	1	9	7
1008	R:R:C470	R:R:V464	5.12	No	Yes	0	9	7
1009	R:R:P524	R:R:V464	1.77	No	Yes	0	9	7
1010	R:R:P465	R:R:Q469	11.05	No	Yes	1	9	9
1011	R:R:Q469	R:R:Y466	6.76	Yes	No	1	9	6
1012	R:R:I610	R:R:Y466	7.25	Yes	No	1	7	6
1013	R:R:A467	R:R:P524	1.87	No	No	0	9	9
1014	R:R:K530	R:R:Y468	17.91	No	Yes	1	8	9
1015	R:R:G609	R:R:Y468	8.69	No	Yes	0	9	9
1016	R:R:I610	R:R:Y468	6.04	Yes	Yes	1	7	9
1017	R:R:E613	R:R:Y468	8.98	Yes	Yes	1	9	9
1018	R:R:P691	R:R:Y468	5.56	Yes	Yes	1	9	9
1019	R:R:I610	R:R:Q469	4.12	Yes	Yes	1	7	9
1020	R:R:C470	R:R:C522	7.28	No	No	0	9	9
1021	R:R:C470	R:R:T526	3.38	No	No	0	9	8
1022	R:R:A606	R:R:C471	3.61	No	No	0	6	9
1023	R:R:F473	R:R:I520	2.51	Yes	No	0	8	5
1024	R:R:S516	R:R:W474	3.71	No	No	0	3	4
1025	R:R:C476	R:R:G475	1.96	No	No	0	8	3
1026	R:R:C522	R:R:G475	1.96	No	No	0	9	3
1027	R:R:Q517	R:R:S516	7.22	No	No	0	5	3
1028	R:R:Q517	T:T:T82	4.25	No	No	0	5	8
1029	R:R:I518	T:T:G80	1.76	No	Yes	0	4	7
1030	R:R:I519	T:T:F60	2.51	No	No	0	4	8
1031	R:R:I519	T:T:Q206	9.61	No	Yes	0	4	9
1032	R:R:P524	R:R:T523	6.99	No	No	0	9	6
1033	R:R:G527	R:R:T526	1.82	No	No	0	9	8
1034	R:R:A528	R:R:P779	3.74	No	No	20	9	8
1035	R:R:A528	R:R:E780	6.03	No	No	20	9	8
1036	R:R:F529	R:R:S690	3.96	Yes	Yes	1	8	8
1037	R:R:F529	R:R:L692	2.44	Yes	No	1	8	7
1038	R:R:F529	R:R:T698	15.56	Yes	No	1	8	4
1039	R:R:F529	R:R:M782	3.73	Yes	No	0	8	5
1040	R:R:E613	R:R:K530	4.05	Yes	No	1	9	8
1041	R:R:K530	R:R:P691	3.35	No	Yes	1	8	9
1042	R:R:L535	R:R:P531	3.28	No	No	1	9	8
1043	R:R:F605	R:R:P531	8.67	Yes	No	1	9	8
1044	R:R:P531	R:R:P691	5.84	No	Yes	1	8	9
1045	R:R:E533	R:R:Y534	11.22	No	No	16	4	4
1046	R:R:E533	R:R:G603	3.27	No	No	16	4	9
1047	R:R:W602	R:R:Y534	22.19	Yes	No	16	4	4
1048	R:R:G603	R:R:Y534	5.79	No	No	16	9	4
1049	R:R:F605	R:R:L535	13.4	Yes	No	1	9	9
1050	R:R:L535	R:R:P691	3.28	No	Yes	1	9	9
1051	R:R:G537	R:R:L536	1.71	No	Yes	0	6	5
1052	R:R:L536	R:R:R542	3.64	Yes	No	0	5	9
1053	R:R:L536	R:R:V545	4.47	Yes	No	0	5	8
1054	R:R:D598	R:R:L536	14.93	No	Yes	0	9	5
1055	R:R:G537	R:R:K783	1.74	No	No	0	6	9
1056	R:R:M540	R:R:S538	4.6	No	No	0	5	9
1057	R:R:I541	R:R:S538	4.64	No	No	0	7	9
1058	R:R:S538	T:T:D218	7.36	No	No	0	9	9
1059	R:R:R542	R:R:W539	13.99	No	No	16	9	9
1060	R:R:W539	R:R:W602	5.62	No	Yes	16	9	4
1061	R:R:M540	T:T:M219	2.89	No	No	31	5	9
1062	R:R:M540	T:T:F222	8.71	No	No	31	5	9
1063	R:R:I541	R:R:S784	4.64	No	No	0	7	7
1064	R:R:I541	T:T:I221	2.94	No	No	0	7	9
1065	R:R:R542	R:R:W602	8	No	Yes	16	9	4
1066	R:R:F547	R:R:L543	3.65	No	No	0	4	5
1067	R:R:I548	R:R:T544	3.04	No	No	0	7	9
1068	R:R:T544	T:T:I221	3.04	No	No	0	9	9
1069	R:R:T595	R:R:V545	3.17	Yes	No	0	7	8
1070	R:R:L787	R:R:V545	2.98	No	No	0	9	8
1071	R:R:F547	R:R:W546	6.01	No	No	0	4	9
1072	R:R:L550	R:R:W546	5.69	No	No	0	3	9
1073	R:R:F547	T:T:F225	4.29	No	No	0	4	9
1074	R:R:C795	R:R:I548	11.46	No	No	0	9	7
1075	R:R:I548	T:T:F225	3.77	No	No	0	7	9
1076	R:R:F549	R:R:L550	4.87	Yes	No	0	5	3
1077	R:R:F549	R:R:L553	6.09	Yes	No	0	5	5
1078	R:R:F549	R:R:T591	2.59	Yes	Yes	0	5	7
1079	R:R:F549	R:R:G592	10.54	Yes	No	21	5	5
1080	R:R:F549	R:R:T595	3.89	Yes	Yes	21	5	7
1081	R:R:F549	R:R:F596	2.14	Yes	No	21	5	4
1082	R:R:F555	R:R:V551	2.62	Yes	No	0	5	6
1083	R:R:C795	R:R:V551	3.42	No	No	0	9	6
1084	R:R:A552	R:R:G588	1.95	No	No	0	8	9
1085	R:R:A552	R:R:A794	1.79	No	No	0	8	8
1086	R:R:A552	R:R:C795	1.81	No	No	0	8	9
1087	R:R:L553	R:R:L557	4.15	No	No	0	5	3
1088	R:R:F554	R:R:F555	4.29	No	Yes	0	3	5
1089	R:R:F555	R:R:P798	2.89	Yes	No	0	5	9
1090	R:R:F555	R:R:V799	6.55	Yes	No	0	5	9
1091	R:R:N556	R:R:S581	10.43	No	Yes	0	9	7
1092	R:R:L585	R:R:N556	6.87	No	No	0	4	9
1093	R:R:N556	R:R:P798	8.15	No	No	0	9	9
1094	R:R:L557	R:R:L585	4.15	No	No	0	3	4
1095	R:R:S581	R:R:V559	4.85	Yes	Yes	0	7	8
1096	R:R:P798	R:R:V559	1.77	No	Yes	0	9	8
1097	R:R:V559	R:R:Y801	6.31	Yes	Yes	0	8	9
1098	R:R:F564	R:R:I560	3.77	No	No	0	8	4
1099	R:R:I560	R:R:S581	3.1	No	Yes	0	4	7
1100	R:R:I560	R:R:V582	3.07	No	No	0	4	3
1101	R:R:F564	R:R:T563	5.19	No	No	0	8	4
1102	R:R:K574	R:R:T563	10.51	Yes	No	0	7	4
1103	R:R:S566	R:R:T568	3.2	No	No	0	5	2
1104	R:R:S569	R:R:T568	3.2	No	No	0	3	2
1105	R:R:P571	R:R:S569	3.56	Yes	No	0	7	3
1106	R:R:L570	R:R:R663	2.43	No	No	0	4	4
1107	R:R:P571	R:R:S573	1.78	Yes	No	0	7	5
1108	R:R:K574	R:R:P571	6.69	Yes	Yes	0	7	7
1109	R:R:F576	R:R:S572	5.28	Yes	No	7	6	6
1110	R:R:E642	R:R:S572	12.94	Yes	No	7	8	6
1111	R:R:F662	R:R:S572	5.28	Yes	No	7	4	6
1112	R:R:R643	R:R:S573	3.95	Yes	No	7	8	5
1113	R:R:M745	R:R:S573	10.73	Yes	No	7	7	5
1114	R:R:K574	R:R:Y801	3.58	Yes	Yes	0	7	9
1115	R:R:D811	R:R:K574	2.77	No	Yes	0	9	7
1116	R:R:L575	R:R:L579	6.92	No	No	0	6	7
1117	R:R:F576	R:R:L638	2.44	Yes	Yes	0	6	7
1118	R:R:A639	R:R:F576	9.71	No	Yes	0	9	6
1119	R:R:E642	R:R:F576	8.16	Yes	Yes	7	8	6
1120	R:R:G578	R:R:I577	1.76	No	No	0	8	5
1121	R:R:I577	R:R:Y801	8.46	No	Yes	0	5	9
1122	R:R:G578	R:R:S581	1.86	No	Yes	0	8	7
1123	R:R:L579	R:R:L635	6.92	No	Yes	0	7	5
1124	R:R:I580	R:R:S583	3.1	No	Yes	5	7	5
1125	R:R:I580	R:R:L635	4.28	No	Yes	5	7	5
1126	R:R:N584	R:R:S583	2.98	Yes	Yes	5	9	5
1127	R:R:S583	R:R:S631	3.26	Yes	Yes	5	5	5
1128	R:R:A632	R:R:S583	3.42	No	Yes	0	5	5
1129	R:R:L635	R:R:S583	3	Yes	Yes	5	5	5
1130	R:R:M587	R:R:N584	2.8	Yes	Yes	5	6	9
1131	R:R:N584	R:R:P793	3.26	Yes	Yes	5	9	9
1132	R:R:A794	R:R:N584	4.69	No	Yes	5	8	9
1133	R:R:N584	R:R:N797	5.45	Yes	Yes	5	9	9
1134	R:R:F586	R:R:I589	2.51	Yes	No	0	6	2
1135	R:R:F586	R:R:L624	4.87	Yes	No	0	6	5
1136	R:R:F586	R:R:F627	4.29	Yes	Yes	0	6	5
1137	R:R:F586	R:R:S628	2.64	Yes	No	0	6	8
1138	R:R:M587	R:R:Y590	3.59	Yes	Yes	5	6	5
1139	R:R:M587	R:R:S628	4.6	Yes	No	0	6	8
1140	R:R:F790	R:R:M587	3.73	Yes	Yes	5	5	6
1141	R:R:M587	R:R:P791	3.35	Yes	No	0	6	9
1142	R:R:A794	R:R:M587	4.83	No	Yes	5	8	6
1143	R:R:G588	R:R:T591	1.82	No	Yes	0	9	7
1144	R:R:I589	R:R:I593	2.94	No	No	0	2	5
1145	R:R:T591	R:R:Y590	6.24	Yes	Yes	0	7	5
1146	R:R:L594	R:R:Y590	8.21	No	Yes	0	9	5
1147	R:R:L624	R:R:Y590	2.34	No	Yes	0	5	5
1148	R:R:A625	R:R:Y590	8.01	No	Yes	0	7	5
1149	R:R:L694	R:R:Y590	8.21	No	Yes	5	7	5
1150	R:R:F790	R:R:Y590	5.16	Yes	Yes	5	5	5
1151	R:R:P791	R:R:T591	6.99	No	Yes	0	9	7
1152	R:R:G592	R:R:T595	5.46	No	Yes	21	5	7
1153	R:R:I593	R:R:W612	2.35	No	Yes	0	5	9
1154	R:R:F596	R:R:T595	2.59	No	Yes	21	4	7
1155	R:R:L597	R:R:W612	14.81	No	Yes	0	8	9
1156	R:R:D598	R:R:W602	2.23	No	Yes	0	9	4
1157	R:R:F605	R:R:S601	7.93	Yes	No	0	9	9
1158	R:R:F608	R:R:S601	3.96	No	No	0	4	9
1159	R:R:E607	R:R:R604	15.12	No	No	0	1	4
1160	R:R:F605	R:R:P691	5.78	Yes	Yes	1	9	9
1161	R:R:E607	R:R:F608	2.33	No	No	0	1	4
1162	R:R:F608	R:R:W611	6.01	No	No	0	4	4
1163	R:R:I610	R:R:T614	3.04	Yes	No	1	7	4
1164	R:R:G617	R:R:W612	4.22	No	Yes	0	7	9
1165	R:R:C693	R:R:W612	2.61	Yes	Yes	0	9	9
1166	R:R:C618	R:R:E613	3.04	No	Yes	0	9	9
1167	R:R:G615	R:R:T614	1.82	No	No	0	7	4
1168	R:R:G617	R:R:V620	1.84	No	No	0	7	3
1169	R:R:C618	R:R:C693	7.28	No	Yes	0	9	9
1170	R:R:K619	R:R:L681	4.23	No	No	0	4	6
1171	R:R:A621	R:R:G622	1.95	No	No	11	5	8
1172	R:R:A621	R:R:C693	1.81	No	Yes	11	5	9
1173	R:R:G622	R:R:Y687	10.14	No	Yes	11	8	5
1174	R:R:C693	R:R:G622	1.96	Yes	No	11	9	8
1175	R:R:F623	R:R:F627	3.22	Yes	Yes	32	4	5
1176	R:R:F623	R:R:T674	2.59	Yes	No	32	4	3
1177	R:R:F623	R:R:G677	3.01	Yes	No	0	4	8
1178	R:R:G677	R:R:V626	3.68	No	No	0	8	6
1179	R:R:V626	R:R:Y687	2.52	No	Yes	11	6	5
1180	R:R:P695	R:R:V626	3.53	No	No	11	9	6
1181	R:R:F627	R:R:F670	6.43	Yes	No	0	5	3
1182	R:R:A673	R:R:F627	2.77	No	Yes	0	8	5
1183	R:R:F627	R:R:T674	6.49	Yes	No	32	5	3
1184	R:R:E630	R:R:S629	7.19	No	No	0	8	8
1185	R:R:F790	R:R:S629	3.96	Yes	No	0	5	8
1186	R:R:E630	R:R:N714	7.89	No	Yes	0	8	9
1187	R:R:L635	R:R:S631	3	Yes	Yes	5	5	5
1188	R:R:F670	R:R:S631	5.28	No	Yes	0	3	5
1189	R:R:A673	R:R:S631	1.71	No	Yes	0	8	5
1190	R:R:I633	R:R:N714	2.83	No	Yes	0	6	9
1191	R:R:F718	R:R:I633	5.02	Yes	No	0	6	6
1192	R:R:A669	R:R:F634	4.16	No	No	0	7	7
1193	R:R:F634	R:R:L713	2.44	No	No	0	7	5
1194	R:R:L636	R:R:M721	8.48	Yes	Yes	5	9	7
1195	R:R:L636	R:R:L752	2.77	Yes	No	5	9	9
1196	R:R:I753	R:R:L636	5.71	Yes	Yes	5	9	9
1197	R:R:L636	R:R:N756	5.49	Yes	Yes	5	9	9
1198	R:R:L638	R:R:M637	2.83	Yes	No	0	7	5
1199	R:R:A665	R:R:L638	3.15	No	Yes	0	5	7
1200	R:R:M721	R:R:T640	4.52	Yes	No	0	7	7
1201	R:R:S644	R:R:V641	3.23	No	No	0	6	6
1202	R:R:E642	R:R:R643	13.96	Yes	Yes	7	8	8
1203	R:R:E642	R:R:S646	5.75	Yes	No	7	8	6
1204	R:R:E642	R:R:F662	5.83	Yes	Yes	7	8	4
1205	R:R:R643	R:R:S646	5.27	Yes	No	7	8	6
1206	R:R:Q742	R:R:R643	10.51	No	Yes	7	7	8
1207	R:R:M745	R:R:R643	3.72	Yes	Yes	7	7	8
1208	R:R:R643	R:R:V749	2.62	Yes	No	0	8	7
1209	R:R:I724	R:R:S644	3.1	Yes	No	33	6	6
1210	R:R:L728	R:R:S644	4.5	Yes	No	33	9	6
1211	R:R:D649	R:R:L645	2.71	No	No	0	1	2
1212	R:R:H658	R:R:L645	9	Yes	No	7	4	2
1213	R:R:F662	R:R:L645	3.65	Yes	No	7	4	2
1214	R:R:A647	R:R:L728	3.15	No	Yes	0	4	9
1215	R:R:H658	R:R:N657	8.93	Yes	No	0	4	3
1216	R:R:H658	R:R:Q661	17.31	Yes	No	7	4	5
1217	R:R:F662	R:R:H658	5.66	Yes	Yes	7	4	4
1218	R:R:L659	R:R:R663	6.07	No	No	0	1	4
1219	R:R:F662	R:R:Q661	7.03	Yes	No	7	4	5
1220	R:R:L668	R:R:V664	2.98	No	No	0	2	2
1221	R:R:G672	R:R:L671	3.42	No	No	0	5	1
1222	R:R:G672	R:R:V675	1.84	No	No	0	5	3
1223	R:R:A676	R:R:G677	1.95	No	No	0	5	8
1224	R:R:C678	R:R:L681	6.35	No	No	0	4	6
1225	R:R:F679	R:R:P680	5.78	No	No	11	5	7
1226	R:R:E686	R:R:F679	8.16	Yes	No	11	4	5
1227	R:R:F679	R:R:F706	19.29	No	Yes	11	5	5
1228	R:R:E686	R:R:P680	9.43	Yes	No	11	4	7
1229	R:R:P680	R:R:Y687	19.47	No	Yes	11	7	5
1230	R:R:E686	R:R:H683	19.69	Yes	No	0	4	4
1231	R:R:G685	R:R:S688	3.71	No	No	0	5	5
1232	R:R:E686	R:R:S703	11.5	Yes	No	11	4	5
1233	R:R:E686	R:R:F706	7	Yes	Yes	11	4	5
1234	R:R:P695	R:R:Y687	8.34	No	Yes	11	9	5
1235	R:R:A689	R:R:T698	3.36	No	No	0	4	4
1236	R:R:A689	R:R:G699	1.95	No	No	0	4	4
1237	R:R:P691	R:R:S690	3.56	Yes	Yes	1	9	8
1238	R:R:L692	R:R:S690	6.01	No	Yes	1	7	8
1239	R:R:S690	R:R:T698	9.59	Yes	No	1	8	4
1240	R:R:L692	R:R:L787	2.77	No	No	0	7	9
1241	R:R:L694	R:R:P697	6.57	No	No	0	7	7
1242	R:R:F790	R:R:L694	2.44	Yes	No	5	5	7
1243	R:R:F696	R:R:P697	10.11	Yes	No	0	7	7
1244	R:R:F696	R:R:T707	2.59	Yes	No	0	7	5
1245	R:R:F696	R:R:L710	12.18	Yes	Yes	0	7	9
1246	R:R:F696	R:R:V763	2.62	Yes	No	5	7	9
1247	R:R:F696	R:R:S767	6.61	Yes	No	0	7	8
1248	R:R:F696	R:R:F790	2.14	Yes	Yes	5	7	5
1249	R:R:P697	R:R:T786	5.25	No	No	0	7	6
1250	R:R:E700	R:R:T701	5.64	No	No	0	3	4
1251	R:R:E700	R:R:P770	14.15	No	No	0	3	9
1252	R:R:E700	R:R:L771	7.95	No	No	0	3	7
1253	R:R:P702	R:R:T701	5.25	No	No	0	5	4
1254	R:R:F706	R:R:S703	5.28	Yes	No	11	5	5
1255	R:R:G705	R:R:L704	1.71	No	No	0	6	6
1256	R:R:G705	R:R:V708	1.84	No	No	0	6	9
1257	R:R:F706	R:R:T709	2.59	Yes	No	0	5	7
1258	R:R:F706	R:R:L710	7.31	Yes	Yes	0	5	9
1259	R:R:L712	R:R:V708	2.98	No	No	0	8	9
1260	R:R:F768	R:R:V708	3.93	Yes	No	0	5	9
1261	R:R:L710	R:R:V711	2.98	Yes	No	0	9	9
1262	R:R:L710	R:R:N714	2.75	Yes	Yes	0	9	9
1263	R:R:F768	R:R:V711	5.24	Yes	No	0	5	9
1264	R:R:F760	R:R:N714	10.87	No	Yes	0	8	9
1265	R:R:F718	R:R:M721	2.49	Yes	Yes	0	6	7
1266	R:R:F718	R:R:N756	2.42	Yes	Yes	0	6	9
1267	R:R:C757	R:R:F718	2.79	No	Yes	0	9	6
1268	R:R:F718	R:R:F760	7.5	Yes	No	0	6	8
1269	R:R:I724	R:R:L720	4.28	Yes	No	0	6	5
1270	R:R:I753	R:R:M721	2.92	Yes	Yes	5	9	7
1271	R:R:I724	R:R:L728	2.85	Yes	Yes	33	6	9
1272	R:R:Y725	R:R:Y729	16.88	Yes	No	0	8	9
1273	R:R:A750	R:R:Y725	2.67	No	Yes	0	9	8
1274	R:R:I753	R:R:Y725	4.84	Yes	Yes	5	9	8
1275	R:R:F754	R:R:Y725	5.16	No	Yes	5	8	8
1276	R:R:K727	R:R:N731	2.8	No	No	0	4	3
1277	R:R:I746	R:R:Y729	3.63	No	No	0	7	9
1278	R:R:M745	R:R:Q742	2.72	Yes	No	7	7	7
1279	R:R:M745	R:R:S744	6.13	Yes	No	0	7	5
1280	R:R:N805	R:R:S744	8.94	Yes	No	0	8	5
1281	R:R:K807	R:R:M745	4.32	Yes	Yes	7	6	7
1282	R:R:H748	R:R:K747	6.55	Yes	No	0	9	7
1283	R:R:H748	R:R:Y801	6.53	Yes	Yes	0	9	9
1284	R:R:F804	R:R:H748	2.26	No	Yes	0	9	9
1285	R:R:H748	R:R:N805	7.65	Yes	Yes	0	9	8
1286	R:R:L800	R:R:W751	6.83	No	No	5	9	8
1287	R:R:F804	R:R:W751	11.02	No	No	5	9	8
1288	R:R:L752	R:R:N756	2.75	No	Yes	5	9	9
1289	R:R:L752	R:R:N797	5.49	No	Yes	5	9	9
1290	R:R:F754	R:R:I753	6.28	No	Yes	5	8	9
1291	R:R:F759	R:R:T755	5.19	Yes	No	5	9	7
1292	R:R:L796	R:R:T755	5.9	Yes	No	5	8	7
1293	R:R:N756	R:R:P793	3.26	Yes	Yes	5	9	9
1294	R:R:N756	R:R:N797	2.72	Yes	Yes	5	9	9
1295	R:R:F759	R:R:I758	5.02	Yes	No	0	9	7
1296	R:R:F759	R:R:F789	2.14	Yes	Yes	0	9	7
1297	R:R:F759	R:R:L792	19.49	Yes	No	0	9	9
1298	R:R:F759	R:R:P793	10.11	Yes	Yes	5	9	9
1299	R:R:F759	R:R:L796	6.09	Yes	Yes	5	9	8
1300	R:R:C761	R:R:P762	3.77	No	No	0	7	9
1301	R:R:F789	R:R:P762	15.89	Yes	No	0	7	9
1302	R:R:F790	R:R:V763	3.93	Yes	No	5	5	9
1303	R:R:A764	R:R:S767	1.71	No	No	0	9	8
1304	R:R:F765	R:R:F766	2.14	No	Yes	0	8	9
1305	R:R:F766	R:R:I781	2.51	Yes	Yes	0	9	8
1306	R:R:F766	R:R:M782	4.98	Yes	No	0	9	5
1307	R:R:F766	R:R:V785	18.35	Yes	No	0	9	7
1308	R:R:F768	R:R:S767	3.96	Yes	No	0	5	8
1309	R:R:F768	R:R:L771	13.4	Yes	No	0	5	7
1310	R:R:A769	R:R:P770	1.87	No	No	0	8	9
1311	R:R:I772	R:R:I775	4.42	No	No	0	8	4
1312	R:R:I775	R:R:I777	5.89	No	No	0	4	6
1313	R:R:I777	R:R:I781	2.94	No	Yes	0	6	8
1314	R:R:I777	R:R:M782	4.37	No	No	0	6	5
1315	R:R:P779	R:R:S778	1.78	No	No	20	8	6
1316	R:R:E780	R:R:S778	2.87	No	No	20	8	6
1317	R:R:I781	R:R:S778	7.74	Yes	No	0	8	6
1318	R:R:E780	R:R:P779	9.43	No	No	20	8	8
1319	R:R:I781	T:T:F217	5.02	Yes	No	0	8	9
1320	R:R:F789	R:R:V785	3.93	Yes	No	0	7	7
1321	R:R:F789	R:R:I788	2.51	Yes	No	0	7	7
1322	R:R:I788	T:T:I221	2.94	No	No	0	7	9
1323	R:R:N797	R:R:P793	4.89	Yes	Yes	5	9	9
1324	R:R:L796	R:R:N797	5.49	Yes	Yes	5	8	9
1325	R:R:L796	R:R:L800	5.54	Yes	No	5	8	9
1326	R:R:F804	R:R:L800	3.65	No	No	5	9	9
1327	R:R:F803	R:R:V802	7.87	No	No	0	7	5
1328	R:R:F808	R:R:V802	9.18	No	No	0	7	5
1329	R:R:F803	T:T:I235	7.54	No	No	0	7	6
1330	R:R:N805	R:R:P806	6.52	Yes	No	0	8	9
1331	R:R:K807	R:R:N805	15.39	Yes	Yes	0	6	8
1332	R:R:E810	R:R:K807	4.05	No	Yes	7	5	6
1333	R:R:D811	R:R:K807	2.77	No	Yes	7	9	6
1334	R:R:D811	R:R:E810	12.99	No	No	7	9	5
1335	R:R:K813	R:R:W812	2.32	No	No	0	4	5
1336	R:R:K813	R:R:R817	3.71	No	No	0	4	3
1337	R:R:L814	R:R:R817	6.07	No	No	0	4	3
1338	R:R:L814	R:R:R818	3.64	No	No	0	4	3
1339	R:R:L815	R:R:V819	2.98	No	No	0	7	1
1340	R:R:K816	R:R:T820	4.5	No	No	0	4	1
1341	T:T:K56	T:T:R84	4.95	No	No	0	8	8
1342	T:T:K56	T:T:R87	11.14	No	No	0	8	5
1343	T:T:E57	T:T:F85	5.83	No	Yes	17	8	8
1344	T:T:E57	T:T:T91	11.29	No	No	17	8	8
1345	T:T:F60	T:T:T58	5.19	No	No	0	8	8
1346	T:T:A59	T:T:F85	5.55	No	Yes	17	9	8
1347	T:T:A59	T:T:V181	3.39	No	Yes	17	9	9
1348	T:T:F60	T:T:T82	3.89	No	No	0	8	8
1349	T:T:L81	T:T:V61	5.96	Yes	No	0	8	9
1350	T:T:I205	T:T:V61	3.07	Yes	No	0	9	9
1351	T:T:E62	T:T:T78	2.82	No	No	2	9	9
1352	T:T:E62	T:T:R204	13.96	No	Yes	2	9	9
1353	T:T:E62	T:T:Q206	6.37	No	Yes	2	9	9
1354	T:T:T79	T:T:V63	3.17	Yes	No	34	9	9
1355	T:T:I194	T:T:V63	3.07	No	No	34	9	9
1356	T:T:R204	T:T:V64	7.85	Yes	No	0	9	9
1357	T:T:L65	T:T:Q198	6.65	No	No	0	9	9
1358	T:T:F66	T:T:Y74	6.19	Yes	Yes	2	9	9
1359	T:T:F66	T:T:V200	2.62	Yes	No	0	9	9
1360	T:T:F66	T:T:R202	3.21	Yes	Yes	2	9	9
1361	T:T:E67	T:T:S69	4.31	No	No	0	9	9
1362	T:T:E67	T:T:T75	7.06	No	No	0	9	8
1363	T:T:S68	T:T:Y74	2.54	No	Yes	0	9	9
1364	T:T:P70	T:T:S69	5.34	No	No	0	6	9
1365	T:T:G72	T:T:S71	1.86	No	No	0	9	6
1366	T:T:T79	T:T:Y77	4.99	Yes	No	0	9	6
1367	T:T:G80	T:T:T79	1.82	Yes	Yes	0	7	9
1368	T:T:K190	T:T:T79	3	No	Yes	0	9	9
1369	T:T:I194	T:T:T79	3.04	No	Yes	34	9	9
1370	T:T:G80	T:T:L81	1.71	Yes	Yes	0	7	8
1371	T:T:D187	T:T:L81	6.79	No	Yes	0	9	8
1372	T:T:L191	T:T:L81	4.15	No	Yes	0	9	8
1373	T:T:G83	T:T:T82	1.82	No	No	0	8	8
1374	T:T:G83	T:T:V181	1.84	No	Yes	0	8	9
1375	T:T:G83	T:T:V183	5.52	No	No	0	8	9
1376	T:T:R84	T:T:Y182	16.46	No	Yes	0	8	9
1377	T:T:F85	T:T:T91	10.38	Yes	No	17	8	8
1378	T:T:F85	T:T:P179	2.89	Yes	Yes	0	8	9
1379	T:T:F85	T:T:V181	2.62	Yes	Yes	17	8	9
1380	T:T:F85	T:T:I205	2.51	Yes	Yes	17	8	9
1381	T:T:F85	T:T:H207	4.53	Yes	No	0	8	9
1382	T:T:A88	T:T:S86	1.71	No	Yes	13	9	9
1383	T:T:L168	T:T:S86	7.51	No	Yes	13	9	9
1384	T:T:S86	T:T:V180	3.23	Yes	Yes	13	9	9
1385	T:T:S86	T:T:Y182	2.54	Yes	Yes	13	9	9
1386	T:T:N169	T:T:R87	3.62	No	No	0	9	5
1387	T:T:R87	T:T:S172	2.64	No	No	0	5	5
1388	T:T:A88	T:T:L168	3.15	No	No	13	9	9
1389	T:T:G89	T:T:L176	1.71	No	No	0	9	9
1390	T:T:G89	T:T:V180	1.84	No	Yes	0	9	9
1391	T:T:L92	T:T:P179	6.57	No	Yes	0	7	9
1392	T:T:Q206	T:T:S93	7.22	Yes	No	0	9	9
1393	T:T:H207	T:T:S93	2.79	No	No	0	9	9
1394	T:T:A94	T:T:P179	1.87	No	Yes	0	9	9
1395	T:T:E95	T:T:R202	11.63	Yes	Yes	2	8	9
1396	T:T:E95	T:T:R204	18.61	Yes	Yes	2	8	9
1397	T:T:G96	T:T:V121	1.84	No	Yes	0	8	9
1398	T:T:G96	T:T:R202	4.5	No	Yes	0	8	9
1399	T:T:E97	T:T:V200	5.7	No	No	0	7	9
1400	T:T:E97	T:T:R202	2.33	No	Yes	0	7	9
1401	T:T:I98	T:T:V123	3.07	No	No	0	8	9
1402	T:T:A203	T:T:I98	3.25	No	No	0	9	8
1403	T:T:V99	T:T:W120	4.9	No	Yes	0	7	9
1404	T:T:L106	T:T:M101	9.9	No	Yes	0	9	9
1405	T:T:M101	T:T:Y116	5.99	Yes	Yes	8	9	9
1406	T:T:M101	T:T:W120	4.65	Yes	Yes	8	9	9
1407	T:T:M101	T:T:R149	3.72	Yes	Yes	8	9	9
1408	T:T:H102	T:T:P103	9.15	Yes	Yes	4	9	9
1409	T:T:H102	T:T:L104	7.71	Yes	Yes	4	9	9
1410	T:T:P103	T:T:V124	1.77	Yes	No	0	9	9
1411	T:T:E127	T:T:P103	11	Yes	Yes	4	9	9
1412	T:T:E127	T:T:L104	5.3	Yes	Yes	4	9	9
1413	T:T:D132	T:T:L104	4.07	Yes	Yes	4	9	9
1414	T:T:K142	T:T:L106	4.23	No	No	0	7	9
1415	T:T:A146	T:T:L106	3.15	No	No	0	9	9
1416	T:T:C107	T:T:C136	7.28	No	No	0	9	9
1417	T:T:L137	T:T:N108	9.61	No	No	0	9	9
1418	T:T:N108	T:T:R145	8.44	No	Yes	0	9	9
1419	T:T:C136	T:T:N109	3.15	No	No	0	9	8
1420	T:T:D111	T:T:N110	4.04	No	No	0	9	9
1421	T:T:E113	T:T:N110	17.09	No	No	0	9	9
1422	T:T:E113	T:T:R145	3.49	No	Yes	8	9	9
1423	T:T:E113	T:T:R149	8.14	No	Yes	8	9	9
1424	T:T:D114	T:T:L115	2.71	No	No	0	9	8
1425	T:T:W120	T:T:Y116	4.82	Yes	Yes	8	9	9
1426	T:T:R149	T:T:Y116	6.17	Yes	Yes	8	9	9
1427	T:T:G119	T:T:Y118	4.35	No	Yes	8	9	9
1428	T:T:G150	T:T:Y118	2.9	No	Yes	8	9	9
1429	T:T:G119	T:T:T152	3.64	No	No	0	9	9
1430	T:T:G122	T:T:W120	2.81	No	Yes	0	9	9
1431	T:T:G150	T:T:W120	4.22	No	Yes	8	9	9
1432	T:T:A151	T:T:W120	7.78	No	Yes	0	9	9
1433	T:T:A153	T:T:V121	1.7	No	Yes	0	9	9
1434	T:T:I155	T:T:V121	3.07	No	Yes	0	9	9
1435	T:T:A203	T:T:V121	5.09	No	Yes	0	9	9
1436	T:T:L191	T:T:V123	2.98	No	No	0	9	9
1437	T:T:F156	T:T:V124	7.87	Yes	No	0	9	9
1438	T:T:D157	T:T:K125	4.15	No	Yes	4	9	9
1439	T:T:K125	T:T:M192	4.32	Yes	Yes	4	9	9
1440	T:T:F156	T:T:L126	4.87	Yes	No	0	9	9
1441	T:T:L126	T:T:N161	5.49	No	No	0	9	9
1442	T:T:E127	T:T:L131	2.65	Yes	Yes	4	9	9
1443	T:T:D132	T:T:E127	7.8	Yes	Yes	4	9	9
1444	T:T:E130	T:T:Q128	11.47	No	No	0	6	9
1445	T:T:L131	T:T:Q128	9.32	Yes	No	0	9	9
1446	T:T:E130	T:T:P129	6.29	No	No	0	6	9
1447	T:T:D132	T:T:L131	2.71	Yes	Yes	4	9	9
1448	T:T:K134	T:T:P133	3.35	No	No	0	9	9
1449	T:T:C136	T:T:L137	3.17	No	No	0	9	9
1450	T:T:G141	T:T:L137	3.42	Yes	No	0	6	9
1451	T:T:L140	T:T:T138	7.37	No	No	35	9	9
1452	T:T:G141	T:T:T138	1.82	Yes	No	35	6	9
1453	T:T:F156	T:T:V139	2.62	Yes	Yes	0	9	9
1454	T:T:A164	T:T:V139	3.39	No	Yes	0	9	9
1455	T:T:Q167	T:T:V139	4.3	No	Yes	0	9	9
1456	T:T:L168	T:T:V139	2.98	No	Yes	0	9	9
1457	T:T:G141	T:T:L140	1.71	Yes	No	35	6	9
1458	T:T:G141	T:T:K144	5.23	Yes	No	0	6	9
1459	T:T:A143	T:T:F156	2.77	No	Yes	0	9	9
1460	T:T:Q148	T:T:R145	8.18	No	Yes	0	9	9
1461	T:T:R145	T:T:R149	11.73	Yes	Yes	8	9	9
1462	T:T:A146	T:T:V154	1.7	No	No	0	9	9
1463	T:T:L176	T:T:V147	4.47	No	No	0	9	9
1464	T:T:R178	T:T:T152	9.06	Yes	No	0	9	9
1465	T:T:A153	T:T:P179	1.87	No	Yes	0	9	9
1466	T:T:F156	T:T:V154	10.49	Yes	No	13	9	9
1467	T:T:V154	T:T:V180	4.81	No	Yes	13	9	9
1468	T:T:I155	T:T:I205	4.42	No	Yes	0	9	9
1469	T:T:F156	T:T:V180	2.62	Yes	Yes	13	9	9
1470	T:T:A188	T:T:D157	6.18	No	No	0	9	9
1471	T:T:D157	T:T:M192	4.16	No	Yes	4	9	9
1472	T:T:A164	T:T:V158	1.7	No	Yes	0	9	9
1473	T:T:I165	T:T:V158	6.14	No	Yes	13	9	9
1474	T:T:V158	T:T:Y182	2.52	Yes	Yes	13	9	9
1475	T:T:E160	T:T:S159	8.62	No	No	0	9	9
1476	T:T:E163	T:T:N161	2.63	No	No	0	8	9
1477	T:T:A164	T:T:N161	4.69	No	No	0	9	9
1478	T:T:E163	T:T:P162	7.86	No	No	0	8	7
1479	T:T:I165	T:T:N169	4.25	No	No	0	9	9
1480	T:T:I165	T:T:Y182	13.3	No	Yes	13	9	9
1481	T:T:G171	T:T:Q170	3.29	No	No	36	5	8
1482	T:T:E173	T:T:Q170	3.82	No	No	36	9	8
1483	T:T:E173	T:T:G171	4.91	No	No	36	9	5
1484	T:T:D174	T:T:E173	3.9	No	No	0	9	9
1485	T:T:K177	T:T:R178	4.95	No	Yes	0	9	9
1486	T:T:P179	T:T:R178	7.21	Yes	Yes	0	9	9
1487	T:T:I205	T:T:V181	4.61	Yes	Yes	17	9	9
1488	T:T:A188	T:T:V183	3.39	No	No	0	9	9
1489	T:T:G185	T:T:K184	1.74	No	No	0	9	9
1490	T:T:I189	T:T:N193	2.83	No	No	0	5	9
1491	T:T:M192	T:T:V195	3.04	Yes	No	4	9	9
1492	T:T:M192	T:T:N196	2.8	Yes	Yes	4	9	9
1493	T:T:I194	T:T:K197	2.91	No	No	0	9	9
1494	T:T:N196	T:T:V195	2.96	Yes	No	4	9	9
1495	T:T:K197	T:T:Q198	10.85	No	No	0	9	9
1496	T:T:Q206	T:T:R204	2.34	Yes	Yes	2	9	9
1497	T:T:Q212	T:T:T214	14.17	No	No	0	8	9
1498	T:T:D218	T:T:E215	3.9	No	No	0	9	9
1499	T:T:F217	T:T:Y216	3.09	No	No	0	9	9
1500	T:T:F222	T:T:M219	4.98	No	No	31	9	9
1501	T:T:F222	T:T:F226	11.79	No	No	0	9	9
1502	T:T:L223	T:T:V227	2.98	No	No	0	9	9
1503	T:T:F226	T:T:V229	2.62	No	No	0	9	9
1504	T:T:L231	T:T:V228	4.47	No	No	0	9	9
1505	T:T:I235	T:T:K239	2.91	No	No	0	6	9
1506	R:R:I263	R:R:P264	1.69	No	No	0	9	9
1507	R:R:C532	R:R:T526	1.69	No	No	0	9	8
1508	R:R:C730	R:R:T726	1.69	No	No	0	8	7
1509	E:E:D73	E:E:G72	1.68	No	No	0	8	9
1510	E:E:D187	E:E:G185	1.68	No	No	0	9	9
1511	R:R:D38	R:R:G37	1.68	No	No	0	6	4
1512	R:R:D225	R:R:G223	1.68	No	No	0	4	9
1513	R:R:D269	R:R:G270	1.68	No	No	0	3	6
1514	E:E:K134	E:E:P135	1.67	No	No	0	9	9
1515	T:T:K134	T:T:P135	1.67	No	No	0	9	9
1516	R:R:E53	R:R:G54	1.64	No	No	0	2	4
1517	R:R:L176	R:R:P177	1.64	No	No	0	9	4
1518	R:R:L247	R:R:P248	1.64	No	No	0	9	4
1519	R:R:L315	R:R:P313	1.64	No	No	0	9	9
1520	R:R:E382	R:R:G383	1.64	No	No	0	4	4
1521	R:R:L570	R:R:P571	1.64	No	Yes	0	4	7
1522	R:R:N271	R:R:P272	1.63	Yes	No	0	9	8
1523	R:R:N282	R:R:P283	1.63	Yes	No	0	9	9
1524	L:L:C113	L:L:K114	1.62	Yes	No	0	9	7
1525	M:M:C113	M:M:K114	1.62	Yes	No	0	9	7
1526	R:R:C33	R:R:K46	1.62	Yes	No	6	9	4
1527	R:R:C43	R:R:K46	1.62	Yes	No	6	8	4
1528	R:R:A100	R:R:I96	1.62	No	Yes	0	8	9
1529	R:R:S601	R:R:V600	1.62	No	No	0	9	4
1530	R:R:A717	R:R:I633	1.62	No	No	0	9	6
1531	R:R:S715	R:R:V711	1.62	No	No	0	7	9
1532	R:R:A774	R:R:I772	1.62	No	No	0	8	8
1533	E:E:A201	L:L:M68	1.61	No	No	0	9	8
1534	E:E:D132	E:E:P133	1.61	No	No	0	9	9
1535	T:T:D132	T:T:P133	1.61	Yes	No	0	9	9
1536	T:T:D174	T:T:P175	1.61	No	No	0	9	9
1537	L:L:S103	L:L:T111	1.6	No	No	0	5	8
1538	R:R:S56	R:R:T59	1.6	No	No	0	6	8
1539	R:R:S427	R:R:T426	1.6	No	No	0	4	4
1540	R:R:V559	R:R:V802	1.6	Yes	No	0	8	5
1541	R:R:C35	R:R:L55	1.59	No	Yes	0	9	6
1542	R:R:T640	R:R:V641	1.59	No	No	0	7	6
1543	R:R:T820	R:R:V819	1.59	No	No	0	1	1
1544	E:E:A88	E:E:L140	1.58	Yes	No	0	9	9
1545	R:R:A100	R:R:L101	1.58	No	No	0	8	7
1546	R:R:A565	R:R:L815	1.58	No	No	0	4	7
1547	R:R:A666	R:R:L579	1.58	No	No	0	5	7
1548	R:R:A669	R:R:L638	1.58	No	Yes	0	7	7
1549	R:R:A647	R:R:L732	1.58	No	No	0	4	7
1550	T:T:P213	T:T:Q212	1.58	No	No	0	9	8
1551	R:R:T562	R:R:T563	1.57	No	No	0	5	4
1552	R:R:A452	R:R:D455	1.54	No	Yes	0	3	4
1553	R:R:I724	R:R:V723	1.54	Yes	No	0	6	3
1554	R:R:K46	R:R:S34	1.53	No	No	0	4	4
1555	R:R:M308	R:R:S307	1.53	No	No	0	4	7
1556	T:T:K184	T:T:V158	1.52	No	Yes	0	9	9
1557	T:T:K199	T:T:V200	1.52	No	No	0	9	9
1558	T:T:K239	T:T:V238	1.52	No	No	0	9	8
1559	L:L:G122	L:L:R121	1.5	No	No	0	9	5
1560	M:M:G122	M:M:R121	1.5	No	No	0	9	5
1561	R:R:G305	R:R:R304	1.5	No	Yes	0	8	8
1562	R:R:K446	R:R:T426	1.5	No	No	0	3	4
1563	R:R:L814	R:R:S566	1.5	No	No	0	4	5
1564	E:E:L191	E:E:V63	1.49	No	No	0	9	9
1565	E:E:L191	E:E:V123	1.49	No	No	0	9	9
1566	R:R:N289	R:R:S290	1.49	No	No	0	4	8
1567	R:R:L719	R:R:V723	1.49	No	No	0	9	3
1568	T:T:L237	T:T:V238	1.49	No	No	0	9	8
1569	E:E:L140	E:E:T138	1.47	No	No	0	9	9
1570	R:R:L561	R:R:T562	1.47	No	No	0	4	5
1571	R:R:L815	R:R:T562	1.47	No	No	0	7	5
1572	T:T:D73	T:T:S69	1.47	No	No	0	8	9
1573	M:M:D136	M:M:T138	1.45	No	No	0	5	6
1574	T:T:I240	T:T:K239	1.45	No	No	0	9	9
1575	R:R:F80	R:R:P81	1.44	Yes	No	0	7	5
1576	R:R:E613	R:R:S688	1.44	Yes	No	0	9	5
1577	R:R:Q154	R:R:V153	1.43	No	No	0	8	3
1578	E:E:K142	E:E:L137	1.41	No	No	0	7	9
1579	R:R:K660	R:R:L659	1.41	No	No	0	1	1
1580	E:E:K197	E:E:N196	1.4	No	No	0	9	9
1581	R:R:K212	R:R:N211	1.4	No	Yes	0	5	9
1582	R:R:K212	R:R:N236	1.4	No	No	0	5	5
1583	R:R:K330	R:R:N354	1.4	No	No	0	5	3
1584	R:R:C567	R:R:F564	1.4	No	No	0	3	8
1585	R:R:C678	R:R:F623	1.4	No	Yes	0	4	4
1586	R:R:L324	R:R:L345	1.38	Yes	No	1	9	9
1587	R:R:L345	R:R:L348	1.38	No	Yes	1	9	9
1588	R:R:L345	R:R:L367	1.38	No	Yes	1	9	7
1589	R:R:D455	R:R:K454	1.38	Yes	No	0	4	5
1590	R:R:L558	R:R:L561	1.38	No	No	0	7	4
1591	R:R:D649	R:R:K648	1.38	No	No	0	1	4
1592	T:T:L231	T:T:L234	1.38	No	No	0	9	9
1593	T:T:L234	T:T:L237	1.38	No	No	0	9	9
1594	E:E:I194	E:E:Q198	1.37	No	No	0	9	9
1595	R:R:H521	R:R:T523	1.37	No	No	0	8	6
1596	R:R:L728	R:R:N731	1.37	Yes	No	0	9	3
1597	R:R:L732	R:R:N731	1.37	No	No	0	7	3
1598	R:R:D297	R:R:L273	1.36	No	No	0	5	6
1599	T:T:M192	T:T:Q100	1.36	Yes	No	0	9	7
1600	R:R:D92	R:R:N68	1.35	No	No	0	5	9
1601	R:R:L400	R:R:Q376	1.33	No	No	0	3	4
1602	R:R:E424	R:R:L400	1.33	No	No	0	3	3
1603	R:R:D92	R:R:Q116	1.31	No	No	0	5	6
1604	R:R:H140	R:R:K118	1.31	No	No	0	8	4
1605	T:T:D166	T:T:Q170	1.31	No	No	0	9	8
1606	E:E:F60	E:E:T82	1.3	No	No	0	8	8
1607	E:E:D174	E:E:E173	1.3	No	No	0	9	9
1608	R:R:Q132	R:R:Q154	1.28	No	No	0	8	8
1609	R:R:Q218	R:R:Q242	1.28	No	No	0	3	4
1610	E:E:E117	E:E:E97	1.27	No	Yes	0	9	7
1611	R:R:T726	R:R:Y725	1.25	No	Yes	0	7	8
1612	R:R:H140	R:R:Q116	1.24	No	No	0	8	6
1613	R:R:H219	R:R:Q218	1.24	No	No	0	5	3
1614	R:R:F808	R:R:K809	1.24	No	No	0	7	6
1615	E:E:Y74	T:T:L115	1.17	Yes	No	0	9	8
1616	T:T:E117	T:T:Y116	1.12	No	Yes	0	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:C43	5.005	4	2	9
2	L:L:N50	9.4325	4	2	9
3	L:L:C52	5.7125	4	2	9
4	L:L:S53	4.825	4	2	6
5	L:L:F61	4.655	6	2	7
6	L:L:F62	7.37333	6	12	6
7	L:L:L63	5.03	5	2	9
8	L:L:R64	8.2075	4	12	6
9	L:L:R65	9.2875	4	2	9
10	L:L:C74	4.8875	4	2	9
11	L:L:H76	9.9175	4	3	7
12	L:L:C78	3.925	4	12	9
13	L:L:P79	4.93	4	12	9
14	L:L:Y82	9.266	5	12	8
15	L:L:R86	8.76333	6	3	9
16	L:L:C93	4.345	4	12	9
17	L:L:F105	5.52286	7	3	9
18	L:L:F109	5.37333	6	3	8
19	L:L:C113	3.616	5	14	9
20	L:L:F117	7.838	5	14	5
21	L:L:C128	3.93	4	0	9
22	M:M:C43	3.615	4	4	9
23	M:M:S47	3.455	4	4	9
24	M:M:D49	6.935	4	4	6
25	M:M:N50	7.3275	4	4	9
26	M:M:L59	3.8125	4	0	7
27	M:M:F61	5.71167	6	4	7
28	M:M:F62	8.17	6	4	6
29	M:M:L63	3.994	5	4	9
30	M:M:R64	10.235	4	4	6
31	M:M:Y71	6.546	5	4	6
32	M:M:G72	2.7	4	4	9
33	M:M:E73	7.625	4	4	7
34	M:M:C78	3.4525	4	4	9
35	M:M:P79	4.81	5	4	9
36	M:M:Y82	6.72	6	4	8
37	M:M:Y83	5.876	5	9	5
38	M:M:M90	5.4375	4	4	5
39	M:M:C93	4.36	4	4	9
40	M:M:C104	2.916	5	9	9
41	M:M:C110	3.202	5	9	9
42	M:M:C113	3.3775	4	9	9
43	M:M:F117	7.056	5	9	5
44	M:M:C124	4.11	4	9	9
45	E:E:F66	5.7225	4	8	9
46	E:E:Y74	5.776	5	8	9
47	E:E:F85	4.40429	7	2	8
48	E:E:S86	4.1225	4	10	9
49	E:E:A88	2.1575	4	10	9
50	E:E:E97	2.39	4	2	7
51	E:E:I98	3.914	5	2	8
52	E:E:M101	4.8675	4	2	9
53	E:E:H102	6.63857	7	2	9
54	E:E:E113	6.5675	4	0	9
55	E:E:Y116	7.412	5	2	9
56	E:E:Y118	6.94833	6	2	9
57	E:E:W120	5.46375	8	2	9
58	E:E:V121	2.925	4	2	9
59	E:E:E127	6.525	4	2	9
60	E:E:L131	4.2725	4	2	9
61	E:E:R149	5.4225	4	2	9
62	E:E:T152	4.704	5	2	9
63	E:E:V154	3.69	4	10	9
64	E:E:F156	4.345	6	10	9
65	E:E:D157	5.0325	4	18	9
66	E:E:V158	3.9775	4	10	9
67	E:E:N161	6.4975	4	24	9
68	E:E:I165	5.67	4	10	9
69	E:E:R178	6.35	5	2	9
70	E:E:P179	4.042	5	2	9
71	E:E:V180	2.93167	6	10	9
72	E:E:Y182	5.818	5	10	9
73	E:E:V183	3.535	4	0	9
74	E:E:R202	5.264	5	8	9
75	R:R:C33	3.595	4	6	9
76	R:R:V41	3.424	5	6	7
77	R:R:C43	3.53	5	6	8
78	R:R:S44	3.742	5	3	7
79	R:R:P52	3.77833	6	6	8
80	R:R:L55	4.535	4	0	6
81	R:R:L62	4.458	5	6	5
82	R:R:D63	5.91	4	3	9
83	R:R:I64	5.03	5	6	6
84	R:R:S65	6.1575	4	3	9
85	R:R:M66	7.17	4	3	9
86	R:R:N67	5.616	5	6	9
87	R:R:F77	3.87429	7	6	7
88	R:R:F80	3.46167	6	6	7
89	R:R:L86	4.9425	4	6	8
90	R:R:L88	3.612	5	0	9
91	R:R:N91	5.195	4	6	9
92	R:R:I96	3.27833	6	1	9
93	R:R:L110	5.19	4	0	9
94	R:R:L112	4.702	5	0	9
95	R:R:Q113	6.574	5	3	9
96	R:R:N114	5.1575	4	3	9
97	R:R:N115	4.174	5	0	9
98	R:R:L117	5.3275	4	1	8
99	R:R:V120	3.48	5	1	7
100	R:R:P121	3.0175	4	1	8
101	R:R:L134	4.07	4	1	9
102	R:R:R135	12.725	4	3	9
103	R:R:L136	3.888	5	1	9
104	R:R:D137	7.525	6	3	9
105	R:R:N139	5.5175	4	1	9
106	R:R:I141	6.0825	4	1	9
107	R:R:V144	5.814	5	1	9
108	R:R:P145	3.898	5	1	9
109	R:R:S148	3.2475	4	1	8
110	R:R:F149	3.37286	7	1	9
111	R:R:R156	9.3	4	0	9
112	R:R:H157	5.37667	6	3	9
113	R:R:L158	4.7175	4	1	9
114	R:R:W159	10.4	5	3	9
115	R:R:L160	4.4925	4	0	9
116	R:R:D161	7.1625	4	3	9
117	R:R:D162	5.9925	4	3	9
118	R:R:V168	3.84	4	1	8
119	R:R:P172	4.82	4	1	9
120	R:R:L179	4.1525	4	1	9
121	R:R:Q180	4.3625	4	3	9
122	R:R:L182	4.364	5	1	8
123	R:R:T183	4.9225	4	3	9
124	R:R:L184	4.1725	4	0	9
125	R:R:I189	6.145	4	0	9
126	R:R:I192	3.13857	7	1	8
127	R:R:F195	6.92	4	27	2
128	R:R:F197	3.83	9	1	9
129	R:R:L203	4.152	5	1	9
130	R:R:V204	4.5825	4	3	9
131	R:R:V205	5.825	4	3	9
132	R:R:L206	4.27333	6	1	9
133	R:R:H207	6.822	5	3	9
134	R:R:L208	5.21	4	0	9
135	R:R:H209	5.968	5	3	9
136	R:R:N210	8.525	4	3	9
137	R:R:N211	5.616	5	1	9
138	R:R:I213	7.11	5	1	9
139	R:R:L216	3.6	5	1	6
140	R:R:C220	4.358	5	1	5
141	R:R:F221	4.245	8	1	9
142	R:R:L224	4.775	4	1	9
143	R:R:L230	5.0225	4	1	9
144	R:R:L232	5.095	4	1	9
145	R:R:N233	6.182	5	3	9
146	R:R:Y234	8.055	4	3	6
147	R:R:N235	7.68	4	1	9
148	R:R:L237	6.03	4	1	8
149	R:R:F240	4.895	4	1	9
150	R:R:E252	5.1075	4	3	9
151	R:R:L253	4.6575	4	0	9
152	R:R:F255	4.74857	7	1	9
153	R:R:H256	12.49	5	3	9
154	R:R:N258	7.1025	4	1	9
155	R:R:I260	5.515	4	1	9
156	R:R:F268	4.18	6	1	9
157	R:R:N271	3.98667	6	1	9
158	R:R:T276	3.4175	4	3	8
159	R:R:I277	3.938	5	1	8
160	R:R:H278	3.3325	4	3	8
161	R:R:L279	3.57	4	1	8
162	R:R:N282	3.574	5	1	9
163	R:R:F292	4.71286	7	1	9
164	R:R:R304	6.215	4	15	8
165	R:R:F312	5.05429	7	1	8
166	R:R:L324	3.256	5	1	9
167	R:R:L326	3.938	5	1	7
168	R:R:T327	6.142	5	15	9
169	R:R:I334	3.422	5	1	7
170	R:R:E341	5.2525	4	0	5
171	R:R:L348	3.256	5	1	9
172	R:R:D349	4.7325	4	15	8
173	R:R:L350	3.66	6	1	9
174	R:R:S351	4.6175	4	15	9
175	R:R:N353	6.42	4	1	9
176	R:R:I355	4.6325	4	1	8
177	R:R:L358	3.3075	4	0	8
178	R:R:P359	4.035	4	0	9
179	R:R:F361	2.786	5	1	6
180	R:R:G363	2.2	4	1	4
181	R:R:L367	3.934	5	1	7
182	R:R:I370	4.498	5	1	7
183	R:R:Q373	5.81	4	0	8
184	R:R:I377	6.4325	4	1	7
185	R:R:L388	4.11	4	1	8
186	R:R:L391	4.8075	4	0	9
187	R:R:R392	8.4525	4	0	6
188	R:R:L394	5.915	4	0	7
189	R:R:I401	4.066	5	1	8
190	R:R:I404	4.5475	4	1	7
191	R:R:L418	4.1725	4	1	9
192	R:R:D419	8.4025	4	0	9
193	R:R:V420	4.82	4	1	6
194	R:R:S421	6.855	4	19	7
195	R:R:L425	6.3125	4	1	9
196	R:R:F428	3.73714	7	1	4
197	R:R:L433	6.0325	4	1	9
198	R:R:N437	4.5625	4	2	5
199	R:R:Q438	9.1525	4	2	9
200	R:R:L439	4.504	5	1	8
201	R:R:L441	4.4175	4	1	8
202	R:R:N444	5.53	5	1	9
203	R:R:L447	3.525	4	1	7
204	R:R:D455	4.2175	4	0	4
205	R:R:F456	4.31333	6	1	5
206	R:R:R460	4.39	4	2	9
207	R:R:L462	5.7125	4	0	7
208	R:R:V464	4.41	5	1	7
209	R:R:Y468	9.436	5	1	9
210	R:R:Q469	7.2725	4	1	9
211	R:R:F473	4.206	5	0	8
212	R:R:F529	6.4225	4	1	8
213	R:R:L536	6.1875	4	0	5
214	R:R:F549	5.02	6	21	5
215	R:R:F555	4.0875	4	0	5
216	R:R:V559	3.6325	4	0	8
217	R:R:P571	3.4175	4	0	7
218	R:R:K574	5.8875	4	0	7
219	R:R:F576	6.3975	4	7	6
220	R:R:S581	5.06	4	0	7
221	R:R:S583	3.152	5	5	5
222	R:R:N584	3.836	5	5	9
223	R:R:F586	3.5775	4	0	6
224	R:R:M587	3.81667	6	5	6
225	R:R:Y590	5.96571	7	5	5
226	R:R:T591	4.41	4	0	7
227	R:R:T595	3.7775	4	21	7
228	R:R:W602	9.51	4	16	4
229	R:R:F605	8.945	4	1	9
230	R:R:I610	4.672	5	1	7
231	R:R:W612	5.9975	4	0	9
232	R:R:E613	4.3775	4	1	9
233	R:R:F623	2.555	4	32	4
234	R:R:F627	4.64	5	32	5
235	R:R:S631	3.3125	4	5	5
236	R:R:L635	4.3	4	5	5
237	R:R:L636	5.6125	4	5	9
238	R:R:L638	2.5	4	0	7
239	R:R:E642	9.328	5	7	8
240	R:R:R643	6.67167	6	7	8
241	R:R:H658	10.225	4	7	4
242	R:R:F662	5.49	5	7	4
243	R:R:E686	11.156	5	11	4
244	R:R:Y687	10.1175	4	11	5
245	R:R:S690	5.78	4	1	8
246	R:R:P691	4.56167	6	1	9
247	R:R:C693	3.415	4	11	9
248	R:R:F696	6.04167	6	5	7
249	R:R:F706	8.294	5	11	5
250	R:R:L710	6.305	4	0	9
251	R:R:N714	6.085	4	0	9
252	R:R:F718	4.044	5	0	6
253	R:R:M721	4.6025	4	5	7
254	R:R:I724	2.9425	4	33	6
255	R:R:Y725	6.16	5	5	8
256	R:R:L728	2.9675	4	33	9
257	R:R:M745	5.524	5	7	7
258	R:R:H748	5.7475	4	0	9
259	R:R:I753	4.9375	4	5	9
260	R:R:N756	3.328	5	5	9
261	R:R:F759	8.00667	6	5	9
262	R:R:F766	6.995	4	0	9
263	R:R:F768	6.6325	4	0	5
264	R:R:I781	4.5525	4	0	8
265	R:R:F789	6.1175	4	0	7
266	R:R:F790	3.56	6	5	5
267	R:R:P793	5.38	4	5	9
268	R:R:L796	5.755	4	5	8
269	R:R:N797	4.808	5	5	9
270	R:R:Y801	6.22	4	0	9
271	R:R:N805	9.625	4	0	8
272	R:R:K807	6.6325	4	7	6
273	T:T:F66	6.8725	4	2	9
274	T:T:Y74	5.342	5	2	9
275	T:T:T79	3.204	5	34	9
276	T:T:G80	1.7475	4	0	7
277	T:T:L81	4.6525	4	0	8
278	T:T:F85	4.90143	7	17	8
279	T:T:S86	3.7475	4	13	9
280	T:T:E95	9.5525	4	2	8
281	T:T:M101	6.065	4	8	9
282	T:T:H102	6.48429	7	4	9
283	T:T:P103	7.11	4	4	9
284	T:T:L104	5.2	5	4	9
285	T:T:Y116	5.06	5	8	9
286	T:T:Y118	6.06143	7	8	9
287	T:T:W120	4.86333	6	8	9
288	T:T:V121	2.925	4	0	9
289	T:T:K125	5.354	5	4	9
290	T:T:E127	6.6875	4	4	9
291	T:T:L131	4.10167	6	4	9
292	T:T:D132	4.0475	4	4	9
293	T:T:V139	3.3225	4	0	9
294	T:T:G141	3.045	4	35	6
295	T:T:R145	7.96	4	8	9
296	T:T:R149	7.44	4	8	9
297	T:T:F156	5.20667	6	13	9
298	T:T:V158	2.97	4	13	9
299	T:T:R178	9.57	4	0	9
300	T:T:P179	4.082	5	0	9
301	T:T:V180	3.125	4	13	9
302	T:T:V181	3.115	4	17	9
303	T:T:Y182	8.705	4	13	9
304	T:T:M192	4	6	4	9
305	T:T:N196	3.355	4	4	9
306	T:T:R202	4.79333	6	2	9
307	T:T:R204	10.684	5	2	9
308	T:T:I205	3.6525	4	17	9
309	T:T:Q206	6.385	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C55	L:L:C74	100	7.28	No	Yes	2	9	9
2	L:L:C55	L:L:F61	100	5.59	No	Yes	2	9	7
3	E:E:H102	L:L:F61	94.7222	3.39	Yes	Yes	2	9	7
4	L:L:H76	L:L:L59	100	11.57	Yes	No	0	7	7
5	L:L:C74	L:L:L59	100	3.17	Yes	No	0	9	7
6	L:L:F61	L:L:L63	93.1524	7.31	Yes	Yes	2	7	9
7	L:L:L63	L:L:Q70	93.1805	7.99	Yes	No	2	9	8
8	E:E:H102	L:L:Q70	93.5151	2.47	Yes	No	2	9	8
9	L:L:Q70	L:L:R65	100	16.35	No	Yes	2	8	9
10	E:E:V99	L:L:R65	61.968	3.92	No	Yes	0	7	9
11	E:E:M101	L:L:R65	62.3128	2.48	Yes	Yes	2	9	9
12	E:E:Y116	L:L:R65	62.3691	14.4	Yes	Yes	2	9	9
13	E:E:A153	E:E:V121	27.3354	1.7	No	Yes	2	9	9
14	E:E:A153	E:E:A94	27.2163	1.79	No	No	2	9	9
15	E:E:A94	E:E:T152	28.5761	3.36	No	Yes	2	9	9
16	E:E:G119	E:E:T152	30.3881	5.46	No	Yes	2	9	9
17	E:E:G119	E:E:Y118	79.2223	4.35	No	Yes	2	9	9
18	E:E:G150	E:E:Y118	100	2.9	No	Yes	2	9	9
19	E:E:G150	E:E:W120	100	2.81	No	Yes	2	9	9
20	E:E:V99	E:E:W120	61.9283	9.81	No	Yes	0	7	9
21	E:E:M101	E:E:W120	61.9944	6.98	Yes	Yes	2	9	9
22	E:E:W120	E:E:Y116	61.9367	1.93	Yes	Yes	2	9	9
23	L:L:H76	R:R:G90	100	4.77	Yes	No	3	7	9
24	E:E:G119	T:T:R202	48.706	4.5	No	Yes	2	9	9
25	T:T:G96	T:T:R202	100	4.5	No	Yes	0	8	9
26	T:T:G96	T:T:V121	100	1.84	No	Yes	0	8	9
27	T:T:A203	T:T:V121	100	5.09	No	Yes	0	9	9
28	T:T:A203	T:T:I98	100	3.25	No	No	0	9	8
29	M:M:M68	T:T:I98	100	5.83	No	No	0	8	8
30	M:M:M68	T:T:V195	100	4.56	No	No	0	8	9
31	T:T:M192	T:T:V195	40.7501	3.04	Yes	No	4	9	9
32	T:T:K125	T:T:M192	38.3534	4.32	Yes	Yes	4	9	9
33	M:M:N50	T:T:K125	37.2753	2.8	Yes	Yes	4	9	9
34	M:M:N50	T:T:H102	18.4581	14.03	Yes	Yes	4	9	9
35	E:E:Y118	T:T:F66	49.238	15.47	Yes	Yes	2	9	9
36	T:T:F66	T:T:R202	97.4255	3.21	Yes	Yes	2	9	9
37	E:E:G150	T:T:Y74	49.6315	4.35	No	Yes	2	9	9
38	T:T:F66	T:T:Y74	49.2424	6.19	Yes	Yes	2	9	9
39	T:T:N196	T:T:V195	95.1333	2.96	Yes	No	4	9	9
40	M:M:R69	T:T:N196	93.5629	3.62	No	Yes	4	8	9
41	M:M:R69	M:M:Y71	65.5765	7.2	No	Yes	4	8	6
42	M:M:N50	T:T:P103	18.4247	6.52	Yes	Yes	4	9	9
43	M:M:E66	M:M:R69	27.5896	2.33	No	No	4	5	8
44	M:M:E66	M:M:R64	27.1898	5.82	No	Yes	4	5	6
45	M:M:F62	M:M:R64	53.6004	8.55	Yes	Yes	4	6	6
46	M:M:C78	M:M:G84	16.036	1.96	Yes	No	0	9	8
47	M:M:F60	M:M:G84	12.0201	4.52	No	No	0	9	8
48	M:M:R64	M:M:Y71	27.2125	10.29	Yes	Yes	4	6	6
49	M:M:E73	M:M:Y71	30.0224	2.24	Yes	Yes	4	7	6
50	M:M:E73	M:M:F62	26.8112	9.33	Yes	Yes	4	7	6
51	M:M:F62	M:M:Y82	64.7725	14.44	Yes	Yes	4	6	8
52	E:E:G96	E:E:V121	24.6905	1.84	No	Yes	0	8	9
53	E:E:G96	E:E:R202	24.5597	4.5	No	Yes	0	8	9
54	E:E:R202	T:T:Y118	23.4847	5.14	Yes	Yes	8	9	9
55	T:T:G150	T:T:Y118	22.242	2.9	No	Yes	8	9	9
56	T:T:G150	T:T:W120	22.1636	4.22	No	Yes	8	9	9
57	M:M:G81	M:M:Y82	27.5791	2.9	No	Yes	0	9	8
58	M:M:C96	M:M:G81	25.1774	3.92	No	No	0	9	9
59	M:M:R95	M:M:Y82	29.9847	9.26	No	Yes	0	7	8
60	M:M:C96	M:M:R95	25.1811	6.96	No	No	0	9	7
61	T:T:M101	T:T:W120	11.7008	4.65	Yes	Yes	8	9	9
62	T:T:E113	T:T:R149	13.72	8.14	No	Yes	8	9	9
63	T:T:E113	T:T:N110	13.4574	17.09	No	No	0	9	9
64	T:T:D111	T:T:N110	13.1881	4.04	No	No	0	9	9
65	M:M:C104	M:M:C96	47.9613	1.82	Yes	No	0	9	9
66	M:M:C104	M:M:C110	45.2951	1.82	Yes	Yes	9	9	9
67	M:M:C110	M:M:C124	18.651	1.82	Yes	Yes	9	9	9
68	M:M:C110	M:M:C113	23.9799	1.82	Yes	Yes	9	9	9
69	M:M:C113	M:M:F117	10.6579	2.79	Yes	Yes	9	9	5
70	M:M:C124	M:M:F117	10.6578	4.19	Yes	Yes	9	9	5
71	M:M:C113	M:M:K114	10.658	1.62	Yes	No	0	9	7
72	M:M:F117	M:M:G116	10.6579	3.01	Yes	No	0	5	7
73	R:R:G90	R:R:N115	100	1.7	No	Yes	0	9	9
74	R:R:L112	R:R:N115	33.6029	2.75	Yes	Yes	0	9	9
75	R:R:N115	R:R:N139	100	4.09	Yes	Yes	0	9	9
76	R:R:L112	R:R:L136	23.2975	4.15	Yes	Yes	0	9	9
77	R:R:L134	R:R:L136	14.3041	5.54	Yes	Yes	1	9	9
78	R:R:L136	R:R:N139	22.0471	2.75	Yes	Yes	1	9	9
79	R:R:I141	R:R:N139	100	4.25	Yes	Yes	1	9	9
80	R:R:L134	R:R:L158	14.2286	4.15	Yes	Yes	1	9	9
81	R:R:L136	R:R:L160	30.9609	4.15	Yes	Yes	0	9	9
82	R:R:I141	R:R:N163	100	14.16	Yes	No	0	9	9
83	R:R:L158	R:R:L182	23.0893	4.15	Yes	Yes	1	9	8
84	R:R:L160	R:R:L184	21.927	4.15	Yes	Yes	0	9	9
85	R:R:N163	R:R:N187	100	4.09	No	No	0	9	9
86	R:R:F197	R:R:L182	14.4079	2.44	Yes	Yes	1	9	8
87	R:R:L184	R:R:L208	11.2083	4.15	Yes	Yes	0	9	9
88	R:R:N187	R:R:N211	100	2.72	No	Yes	0	9	9
89	R:R:L182	R:R:L206	14.5706	4.15	Yes	Yes	1	8	9
90	R:R:C220	R:R:I192	11.0473	3.27	Yes	Yes	1	5	8
91	R:R:C220	R:R:F221	14.2987	8.38	Yes	Yes	1	5	9
92	R:R:C220	R:R:S217	25.0985	5.16	Yes	No	0	5	6
93	R:R:D194	R:R:S217	22.8169	10.31	No	No	0	8	6
94	R:R:D194	R:R:F195	13.6902	2.39	No	Yes	27	8	2
95	R:R:N211	R:R:N235	100	2.72	Yes	Yes	1	9	9
96	R:R:N235	R:R:N258	100	2.72	Yes	Yes	1	9	9
97	R:R:L230	R:R:L253	10.5256	4.15	Yes	Yes	0	9	9
98	R:R:F255	R:R:N258	100	4.83	Yes	Yes	1	9	9
99	R:R:F255	R:R:I277	65.5831	2.51	Yes	Yes	1	9	8
100	R:R:F255	R:R:L279	65.4707	4.87	Yes	Yes	1	9	8
101	R:R:F292	R:R:I277	65.4275	2.51	Yes	Yes	1	9	8
102	R:R:F292	R:R:L279	65.4573	2.44	Yes	Yes	1	9	8
103	R:R:F292	R:R:L301	100	12.18	Yes	No	1	9	9
104	R:R:L301	R:R:L324	100	4.15	No	Yes	1	9	9
105	R:R:L324	R:R:L348	61.8223	2.77	Yes	Yes	1	9	9
106	R:R:F361	R:R:L348	61.654	2.44	Yes	Yes	1	6	9
107	R:R:F361	R:R:I370	58.9127	2.51	Yes	Yes	1	6	7
108	R:R:I370	R:R:L394	100	2.85	Yes	Yes	0	7	7
109	R:R:L394	R:R:L418	100	4.15	Yes	Yes	0	7	9
110	R:R:L418	R:R:L439	100	4.15	Yes	Yes	1	9	8
111	R:R:L439	R:R:L462	100	4.15	Yes	Yes	0	8	7
112	R:R:L462	R:R:V464	100	4.47	Yes	Yes	0	7	7
113	R:R:L324	R:R:L345	61.1506	1.38	Yes	No	1	9	9
114	R:R:L345	R:R:L367	61.0427	1.38	No	Yes	1	9	7
115	R:R:I370	R:R:L367	58.8473	7.14	Yes	Yes	1	7	7
116	R:R:Q469	R:R:V464	96.0767	7.16	Yes	Yes	1	9	7
117	R:R:I610	R:R:Q469	95.985	4.12	Yes	Yes	1	7	9
118	R:R:I610	R:R:Y468	95.0923	6.04	Yes	Yes	1	7	9
119	R:R:E613	R:R:Y468	28.837	8.98	Yes	Yes	1	9	9
120	R:R:P691	R:R:Y468	65.6049	5.56	Yes	Yes	1	9	9
121	R:R:P691	R:R:S690	63.3598	3.56	Yes	Yes	1	9	8
122	R:R:F529	R:R:S690	41.1041	3.96	Yes	Yes	1	8	8
123	R:R:F529	R:R:M782	40.8893	3.73	Yes	No	0	8	5
124	R:R:F766	R:R:M782	37.9403	4.98	Yes	No	0	9	5
125	R:R:L692	R:R:S690	21.3498	6.01	No	Yes	1	7	8
126	R:R:L692	R:R:L787	21.1327	2.77	No	No	0	7	9
127	R:R:L787	R:R:V545	20.9078	2.98	No	No	0	9	8
128	R:R:F766	R:R:V785	35.6903	18.35	Yes	No	0	9	7
129	R:R:F789	R:R:V785	35.4647	3.93	Yes	No	0	7	7
130	R:R:T595	R:R:V545	17.5419	3.17	Yes	No	0	7	8
131	R:R:F549	R:R:T595	16.8629	3.89	Yes	Yes	21	5	7
132	R:R:F549	R:R:L553	11.3889	6.09	Yes	No	0	5	5
133	R:R:L553	R:R:L557	11.1602	4.15	No	No	0	5	3
134	R:R:L557	R:R:L585	10.9317	4.15	No	No	0	3	4
135	R:R:L585	R:R:N556	10.7035	6.87	No	No	0	4	9
136	R:R:C618	R:R:E613	28.166	3.04	No	Yes	0	9	9
137	R:R:C618	R:R:C693	27.9402	7.28	No	Yes	0	9	9
138	R:R:C693	R:R:W612	11.134	2.61	Yes	Yes	0	9	9
139	R:R:I593	R:R:W612	10.2308	2.35	No	Yes	0	5	9
140	R:R:I589	R:R:I593	10.0056	2.94	No	No	0	2	5
141	R:R:F759	R:R:F789	31.6241	2.14	Yes	Yes	0	9	7
142	R:R:F759	R:R:L796	19.7819	6.09	Yes	Yes	5	9	8
143	R:R:L796	R:R:L800	19.2146	5.54	Yes	No	5	8	9
144	R:R:F804	R:R:L800	18.7575	3.65	No	No	5	9	9
145	R:R:F804	R:R:H748	18.53	2.26	No	Yes	0	9	9
146	R:R:H748	R:R:N805	11.8912	7.65	Yes	Yes	0	9	8
147	R:R:F759	R:R:P793	10.9412	10.11	Yes	Yes	5	9	9
148	R:R:C693	R:R:G622	16.3589	1.96	Yes	No	11	9	8
149	R:R:G622	R:R:Y687	16.1325	10.14	No	Yes	11	8	5
150	R:R:P680	R:R:Y687	13.869	19.47	No	Yes	11	7	5
151	R:R:F706	R:R:L710	11.848	7.31	Yes	Yes	0	5	9
152	T:T:P103	T:T:V124	13.6452	1.77	Yes	No	0	9	9
153	T:T:F156	T:T:V124	13.244	7.87	Yes	No	0	9	9
154	R:R:G90	R:R:N114	10.3472	1.7	No	Yes	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:S45	T:T:L131	3	4	No	Yes	5	9	0	1
M:M:S47	T:T:K125	3.06	4	Yes	Yes	9	9	0	1
M:M:D49	T:T:K125	12.44	4	Yes	Yes	6	9	0	1
M:M:D49	T:T:M192	8.32	4	Yes	Yes	6	9	0	1
M:M:D49	T:T:N196	4.04	4	Yes	Yes	6	9	0	1
M:M:N50	T:T:H102	14.03	4	Yes	Yes	9	9	0	1
M:M:N50	T:T:P103	6.52	4	Yes	Yes	9	9	0	1
M:M:N50	T:T:K125	2.8	4	Yes	Yes	9	9	0	1
M:M:S53	T:T:H102	2.79	4	No	Yes	6	9	0	1
M:M:S53	T:T:L131	4.5	4	No	Yes	6	9	0	1
M:M:R54	T:T:L131	2.43	0	No	Yes	6	9	0	1
M:M:F61	T:T:H102	3.39	4	Yes	Yes	7	9	0	1
M:M:F61	T:T:L104	6.09	4	Yes	Yes	7	9	0	1
M:M:L63	T:T:H102	5.14	4	Yes	Yes	9	9	0	1
M:M:L63	T:T:G105	1.71	4	Yes	No	9	9	0	1
M:M:R65	T:T:V99	3.92	0	No	No	9	7	0	1
M:M:R65	T:T:Y116	7.2	0	No	Yes	9	9	0	1
M:M:M68	T:T:I98	5.83	0	No	No	8	8	0	1
M:M:M68	T:T:V195	4.56	0	No	No	8	9	0	1
M:M:M68	T:T:A201	3.22	0	No	No	8	9	0	1
M:M:R69	T:T:N196	3.62	4	No	Yes	8	9	0	1
M:M:G72	T:T:H102	3.18	4	Yes	Yes	9	9	0	1
M:M:Y83	T:T:D111	5.75	9	Yes	No	5	9	0	1
M:M:M90	T:T:L104	2.83	4	Yes	Yes	5	9	0	1
M:M:R97	T:T:E112	13.96	0	No	No	5	9	0	1
M:M:K107	T:T:D111	6.91	9	No	No	5	9	0	1
E:E:S71	T:T:E112	8.62	0	No	No	6	9	2	1
T:T:I98	T:T:V123	3.07	0	No	No	8	9	1	2
T:T:A203	T:T:I98	3.25	0	No	No	9	8	2	1
T:T:V99	T:T:W120	4.9	0	No	Yes	7	9	1	2
T:T:M101	T:T:Y116	5.99	8	Yes	Yes	9	9	2	1
T:T:M101	T:T:W120	4.65	8	Yes	Yes	9	9	2	2
T:T:M101	T:T:R149	3.72	8	Yes	Yes	9	9	2	2
T:T:H102	T:T:P103	9.15	4	Yes	Yes	9	9	1	1
T:T:H102	T:T:L104	7.71	4	Yes	Yes	9	9	1	1
T:T:P103	T:T:V124	1.77	4	Yes	No	9	9	1	2
T:T:E127	T:T:P103	11	4	Yes	Yes	9	9	2	1
T:T:E127	T:T:L104	5.3	4	Yes	Yes	9	9	2	1
T:T:D132	T:T:L104	4.07	4	Yes	Yes	9	9	2	1
T:T:D111	T:T:N110	4.04	9	No	No	9	9	1	2
T:T:W120	T:T:Y116	4.82	8	Yes	Yes	9	9	2	1
T:T:R149	T:T:Y116	6.17	8	Yes	Yes	9	9	2	1
T:T:D157	T:T:K125	4.15	4	No	Yes	9	9	2	1
T:T:K125	T:T:M192	4.32	4	Yes	Yes	9	9	1	1
T:T:E127	T:T:L131	2.65	4	Yes	Yes	9	9	2	1
T:T:D132	T:T:E127	7.8	4	Yes	Yes	9	9	2	2
T:T:L131	T:T:Q128	9.32	4	Yes	No	9	9	1	2
T:T:D132	T:T:L131	2.71	4	Yes	Yes	9	9	2	1
T:T:D157	T:T:M192	4.16	4	No	Yes	9	9	2	1
T:T:M192	T:T:V195	3.04	4	Yes	No	9	9	1	1
T:T:M192	T:T:N196	2.8	4	Yes	Yes	9	9	1	1
T:T:N196	T:T:V195	2.96	4	Yes	No	9	9	1	1
T:T:M192	T:T:Q100	1.36	4	Yes	No	9	7	1	2
T:T:E117	T:T:Y116	1.12	0	No	Yes	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
78.95	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
68.42	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
68.42	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
68.42	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
65.00	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
61.90	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
59.09	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
57.14	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
50.00	Single	9KB8	R-spondin-2	9KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
E:E:L131	L:L:S45	6.01	2	Yes	No	9	5	1	0
E:E:E127	L:L:S47	4.31	2	Yes	No	9	9	1	0
E:E:K125	L:L:D49	9.68	18	No	No	9	6	1	0
E:E:M192	L:L:D49	8.32	18	No	No	9	6	1	0
E:E:N196	L:L:D49	6.73	0	No	No	9	6	1	0
E:E:H102	L:L:N50	11.48	2	Yes	Yes	9	9	1	0
E:E:P103	L:L:N50	9.77	2	No	Yes	9	9	1	0
E:E:E127	L:L:N50	10.52	2	Yes	Yes	9	9	1	0
E:E:H102	L:L:S53	2.79	2	Yes	Yes	9	6	1	0
E:E:E127	L:L:S53	8.62	2	Yes	Yes	9	6	1	0
E:E:L131	L:L:S53	3	2	Yes	Yes	9	6	1	0
L:L:K58	R:R:N114	5.6	0	No	Yes	8	9	0	1
L:L:K58	R:R:D162	6.91	0	No	Yes	8	9	0	1
E:E:H102	L:L:F61	3.39	2	Yes	Yes	9	7	1	0
E:E:L104	L:L:F61	3.65	2	No	Yes	9	7	1	0
E:E:H102	L:L:L63	6.43	2	Yes	Yes	9	9	1	0
E:E:G105	L:L:L63	1.71	0	No	Yes	9	9	1	0
E:E:V99	L:L:R65	3.92	0	No	Yes	7	9	1	0
E:E:M101	L:L:R65	2.48	2	Yes	Yes	9	9	1	0
E:E:Y116	L:L:R65	14.4	2	Yes	Yes	9	9	1	0
E:E:E97	L:L:M68	2.71	2	Yes	No	7	8	1	0
E:E:I98	L:L:M68	5.83	2	Yes	No	8	8	1	0
E:E:Q100	L:L:R69	2.34	0	No	No	7	8	1	0
E:E:N196	L:L:R69	3.62	0	No	No	9	8	1	0
E:E:H102	L:L:Q70	2.47	2	Yes	No	9	8	1	0
L:L:H76	R:R:M66	13.13	3	Yes	Yes	7	9	0	1
L:L:H76	R:R:G90	4.77	3	Yes	No	7	9	0	1
L:L:H76	R:R:N114	10.2	3	Yes	Yes	7	9	0	1
L:L:S77	R:R:Q113	2.89	0	No	Yes	7	9	0	1
L:L:H85	R:R:H209	5.97	0	No	Yes	4	9	0	1
L:L:R86	R:R:D137	11.91	3	Yes	Yes	9	9	0	1
L:L:R86	R:R:A138	4.15	3	Yes	No	9	9	0	1
L:L:R86	R:R:D161	8.34	3	Yes	Yes	9	9	0	1
L:L:R86	R:R:D162	3.57	3	Yes	Yes	9	9	0	1
L:L:P88	R:R:L186	3.28	3	No	No	5	9	0	1
L:L:P88	R:R:N210	4.89	3	No	Yes	5	9	0	1
E:E:L104	L:L:M90	2.83	2	No	No	9	5	1	0
E:E:E112	L:L:R97	5.82	0	No	No	9	5	1	0
L:L:F105	R:R:H157	3.39	3	Yes	Yes	9	9	0	1
L:L:F105	R:R:W159	13.03	3	Yes	Yes	9	9	0	1
L:L:F105	R:R:A181	8.32	3	Yes	No	9	9	0	1
L:L:F105	R:R:T183	2.59	3	Yes	Yes	9	9	0	1
L:L:F105	R:R:H207	2.26	3	Yes	Yes	9	9	0	1
L:L:S106	R:R:H207	5.58	3	No	Yes	8	9	0	1
L:L:K107	R:R:E252	8.1	0	No	Yes	5	9	0	1
L:L:F109	R:R:H157	5.66	3	Yes	Yes	8	9	0	1
L:L:F109	R:R:Q180	2.34	3	Yes	Yes	8	9	0	1
L:L:F109	R:R:V204	6.55	3	Yes	Yes	8	9	0	1
L:L:F109	R:R:V205	5.24	3	Yes	Yes	8	9	0	1
L:L:T111	R:R:H157	8.21	0	No	Yes	8	9	0	1
L:L:R121	R:R:N226	4.82	0	No	No	5	8	0	1
L:L:E140	R:R:R156	5.82	0	No	Yes	8	9	0	1
E:E:E97	E:E:I98	2.73	2	Yes	Yes	7	8	1	1
E:E:E97	E:E:V200	2.85	2	Yes	No	7	9	1	2
E:E:I98	E:E:V121	3.07	2	Yes	Yes	8	9	1	2
E:E:I98	E:E:V123	3.07	2	Yes	No	8	9	1	2
E:E:A203	E:E:I98	4.87	2	No	Yes	9	8	2	1
E:E:V99	E:E:W120	9.81	0	No	Yes	7	9	1	2
E:E:Q100	E:E:V195	4.3	0	No	No	7	9	1	2
E:E:L106	E:E:M101	2.83	0	No	Yes	9	9	2	1
E:E:M101	E:E:Y116	7.18	2	Yes	Yes	9	9	1	1
E:E:M101	E:E:W120	6.98	2	Yes	Yes	9	9	1	2
E:E:H102	E:E:P103	12.2	2	Yes	No	9	9	1	1
E:E:H102	E:E:L104	7.71	2	Yes	No	9	9	1	1
E:E:P103	E:E:V124	1.77	2	No	No	9	9	1	2
E:E:E112	E:E:E113	2.54	0	No	Yes	9	9	1	2
E:E:E112	T:T:S71	2.87	0	No	No	9	6	1	2
E:E:D114	E:E:E113	2.6	0	No	Yes	9	9	2	2
E:E:E113	E:E:R149	9.3	0	Yes	Yes	9	9	2	2
E:E:D114	E:E:Y116	11.49	0	No	Yes	9	9	2	1
E:E:W120	E:E:Y116	1.93	2	Yes	Yes	9	9	2	1
E:E:R149	E:E:Y116	2.06	2	Yes	Yes	9	9	2	1
E:E:R149	E:E:W120	5	2	Yes	Yes	9	9	2	2
E:E:A203	E:E:V121	5.09	2	No	Yes	9	9	2	2
E:E:D157	E:E:K125	4.15	18	Yes	No	9	9	2	1
E:E:K125	E:E:M192	5.76	18	No	No	9	9	1	1
E:E:E127	E:E:L131	2.65	2	Yes	Yes	9	9	1	1
E:E:D132	E:E:L131	5.43	0	No	Yes	9	9	2	1
E:E:D157	E:E:M192	6.93	18	Yes	No	9	9	2	1
R:R:G45	R:R:S44	1.86	3	No	Yes	8	7	2	2
R:R:S44	R:R:S65	4.89	3	Yes	Yes	7	9	2	2
R:R:M66	R:R:S44	4.6	3	Yes	Yes	9	7	1	2
R:R:G45	R:R:M66	1.75	3	No	Yes	8	9	2	1
R:R:M66	R:R:S65	9.2	3	Yes	Yes	9	9	1	2
R:R:A89	R:R:S65	1.71	0	No	Yes	9	9	2	2
R:R:A89	R:R:Q113	4.55	0	No	Yes	9	9	2	1
R:R:G90	R:R:N114	1.7	3	No	Yes	9	9	1	1
R:R:G90	R:R:N115	1.7	3	No	Yes	9	9	1	2
R:R:Q113	R:R:T111	7.09	3	Yes	No	9	9	1	2
R:R:R135	R:R:T111	11.64	3	Yes	No	9	9	2	2
R:R:Q113	R:R:R135	10.51	3	Yes	Yes	9	9	1	2
R:R:D137	R:R:Q113	7.83	3	Yes	Yes	9	9	1	1
R:R:A138	R:R:N114	3.13	3	No	Yes	9	9	1	1
R:R:Q132	R:R:R156	17.52	0	No	Yes	8	9	2	1
R:R:H157	R:R:S133	8.37	3	Yes	No	9	9	1	2
R:R:D137	R:R:R135	4.76	3	Yes	Yes	9	9	1	2
R:R:R135	R:R:W159	23.99	3	Yes	Yes	9	9	2	1
R:R:A138	R:R:D137	3.09	3	No	Yes	9	9	1	1
R:R:D137	R:R:W159	5.58	3	Yes	Yes	9	9	1	1
R:R:D137	R:R:D161	11.98	3	Yes	Yes	9	9	1	1
R:R:H157	R:R:R156	4.51	3	Yes	Yes	9	9	1	1
R:R:Q180	R:R:R156	9.35	3	Yes	Yes	9	9	1	1
R:R:H157	R:R:W159	2.12	3	Yes	Yes	9	9	1	1
R:R:T183	R:R:W159	7.28	3	Yes	Yes	9	9	1	1
R:R:D161	R:R:D162	3.99	3	Yes	Yes	9	9	1	1
R:R:D161	R:R:T183	4.34	3	Yes	Yes	9	9	1	1
R:R:D162	R:R:L186	9.5	3	Yes	No	9	9	1	1
R:R:Q180	R:R:S202	2.89	3	Yes	No	9	8	1	2
R:R:Q180	R:R:V204	2.87	3	Yes	Yes	9	9	1	1
R:R:H207	R:R:T183	5.48	3	Yes	Yes	9	9	1	1
R:R:A185	R:R:H209	7.32	0	No	Yes	9	9	2	1
R:R:L186	R:R:N210	10.98	3	No	Yes	9	9	1	1
R:R:V204	R:R:V205	3.21	3	Yes	Yes	9	9	1	1
R:R:E228	R:R:V204	5.7	0	No	Yes	9	9	2	1
R:R:H207	R:R:V205	6.92	3	Yes	Yes	9	9	1	1
R:R:T229	R:R:V205	7.93	0	No	Yes	9	9	2	1
R:R:D231	R:R:H207	13.87	3	No	Yes	9	9	2	1
R:R:H209	R:R:N210	8.93	3	Yes	Yes	9	9	1	1
R:R:D231	R:R:H209	2.52	3	No	Yes	9	9	2	1
R:R:H209	R:R:N233	5.1	3	Yes	Yes	9	9	1	2
R:R:N210	R:R:Y234	9.3	3	Yes	Yes	9	6	1	2
R:R:E252	R:R:T229	5.64	3	Yes	No	9	9	1	2
R:R:D231	R:R:N233	4.04	3	No	Yes	9	9	2	2
R:R:N233	R:R:Y234	3.49	3	Yes	Yes	9	6	2	2
R:R:E252	R:R:T276	4.23	3	Yes	Yes	9	8	1	2
R:R:E252	R:R:H278	2.46	3	Yes	Yes	9	8	1	2
R:R:H278	R:R:T276	4.11	3	Yes	Yes	8	8	2	2
E:E:A201	L:L:M68	1.61	0	No	No	9	8	1	0
E:E:K197	E:E:N196	1.4	0	No	No	9	9	2	1
E:E:E117	E:E:E97	1.27	0	No	Yes	9	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
84.21	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
76.19	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
76.19	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
71.43	Single	9KB8	R-spondin-2	9KB8-LGR4-R-spondin-2-ZNRF3; ZNRF3
66.67	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
66.67	Single	8Y69	R-spondin-2	8Y69-LGR4; LGR4-R-spondin-2-ZNRF3
65.22	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3; ZNRF3
65.00	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3; ZNRF3
63.64	Single	9KB9	R-spondin-2	9KB9-LGR4; LGR4-R-spondin-2-ZNRF3; ZNRF3
5.56	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
5.56	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
5.56	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
5.56	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
5.56	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
5.56	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
5.56	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042
5.56	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
5.56	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042
5.56	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
5.56	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
5.56	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626
5.56	Single	7DD5	Ca	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DD5	Ca	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
5.56	Single	7DTT	Ca	7DTT-CaS; CaS-Ca-Ca
5.56	Single	7DTT	Ca	7DTT-CaS; CaS-Ca-Ca
5.56	Single	7DTU	Tryptophan	7DTU-CaS; CaS-Tryptophan
5.56	Single	7DTU	Tryptophan	7DTU-CaS; CaS-Tryptophan
5.56	Single	7DTV	Ca	7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56	Single	7DTV	Ca; Tryptophan	7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56	Single	7DTV	Ca	7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56	Single	7DTV	Ca; Tryptophan	7DTV-CaS; CaS-Ca-Ca; Tryptophan
5.56	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7E6T	Ca	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7E6T	Ca	7E6T-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.56	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.56	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.56	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
5.56	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
5.56	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
5.56	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
5.56	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
5.56	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
5.56	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.56	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.56	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet	7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.56	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
5.56	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
5.56	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.56	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.56	Single	7SIL	Ca	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56	Single	7SIL	Ca	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	7SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
5.56	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7SIM	Ca	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7SIM	Ca	7SIM-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.56	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
5.56	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
5.56	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
5.56	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
5.56	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
5.56	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
5.56	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
5.56	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.56	Single	7XW7	K1-70	7XW7-TSH-K1-70
5.56	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
5.56	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
5.56	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
5.56	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
5.56	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
5.56	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
5.56	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
5.56	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
5.56	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
5.56	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
5.56	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
5.56	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
5.56	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.56	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
5.56	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
5.56	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
5.56	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
5.56	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
5.56	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
5.56	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
5.56	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
5.56	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.56	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
5.56	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
5.56	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
5.56	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
5.56	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.56	Single	8TQB	Ca; LY379268	8TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56	Single	8TQB	Ca; LY379268	8TQB-mGlu3; mGlu3-Ca; LY379268-Ca
5.56	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
5.56	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
5.56	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.56	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
5.56	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
5.56	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
5.56	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
5.56	Single	8WG9	PubChem 179394	8WG9-mGlu4; mGlu2-PubChem 179394
5.56	Single	8WGB	Glutamate	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56	Single	8WGB	Glutamate	8WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
5.56	Single	8WGC	LY379268	8WGC-mGlu2; mGlu4-LY379268
5.56	Single	8WGD	LY341495; CPPG	8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56	Single	8WGD	LY341495; CPPG	8WGD-mGlu4; mGlu2-LY341495; CPPG
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
5.56	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8WVX	Norrin	8WVX-LGR4-Norrin
5.56	Single	8WVY	Norrin	8WVY-LGR4-Norrin
5.56	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.56	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
5.56	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
5.56	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU29
5.56	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
5.56	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
5.56	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
5.56	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
5.56	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
5.56	Single	9ASB	Ca	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AVG	Ca	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9AVL	Ca	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56	Single	9AVL	Ca	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
5.56	Single	9AXF	Ca	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AXF	Ca	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AYF	Ca	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.56	Single	9C1P	Ca	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C1P	Ca	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
5.56	Single	9C2F	Ca	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56	Single	9C2F	Ca	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56	Single	9C2F	Ca; Ca; Tryptophan; '54149; PO4	9C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
5.56	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2; Arrestin2
5.56	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.56	Single	9KB7	R-spondin-2	9KB7-LGR4-R-spondin-2
5.56	Single	9KGK	NB18	9KGK-LGR4-NB18
5.56	Single	9KHH	Norrin	9KHH-LGR4-Norrin
5.56	Single	9MBA	Glutamate	9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56	Single	9MBA	Glutamate	9MBA-mGlu8; mGlu8-Glutamate-Arrestin2 ; Arrestin2
5.56	Single	9MBB	LY341495	9MBB-mGlu8; mGlu8-LY341495
5.56	Single	9MBB	LY341495	9MBB-mGlu8; mGlu8-LY341495
5.56	Single	9MBC	DCPG	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56	Single	9MBC	DCPG	9MBC-mGlu8; mGlu8-DCPG-AZ12216052
5.56	Single	9S37	NB21	9S37-LGR4-NB21
5.56	Single	9S38	NB21	9S38-LGR4-NB21
5.56	Single	9UTB	Sucralose	9UTB-TAS1R2; TAS1R3-Sucralose
5.26	Single	7DD6	Ca	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26	Single	7DD6	Ca	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS; CaS-Ca-Ca; Ca; Tryptophan
5.26	Single	7DD7	Ca	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7DD7	Ca	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine	8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.26	Single	9ASB	Ca	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26	Single	9AVG	Ca	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9AYF	Ca	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.26	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4	9AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
5.00	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.00	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
4.76	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
4.76	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.76	Single	7UTZ	TSH	7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
4.76	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.76	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
4.55	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
4.55	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
4.55	Single	8I2G	FSH	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
4.55	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.35	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
4.35	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.35	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
4.17	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
4.17	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
4.17	Single	8JEF	PubChem 11367166	8JEF-HCA₃-PubChem 11367166-Gi1/β1/γ2
4.17	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
4.17	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
4.17	Single	9IJR	C17	9IJR-GPR52-C17-Arrestin2
4.17	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
4.00	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
4.00	Single	6LI0	C17	6LI0-GPR52-C17
4.00	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.00	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab
4.00	Single	9B9Y	Taranabant	9B9Y-CB₁-Taranabant
4.00	Single	9E7R	GB88	9E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.00	Single	9MNI	dC2_05	9MNI-CTLike-dC2_05-RAMP1
3.85	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
3.85	Single	4BWB	Neurotensin-(8-12)	4BWB-NTS₁-Neurotensin-(8-12)
3.85	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
3.85	Single	5U09	Taranabant	5U09-CB₁-Taranabant
3.85	Single	6LFO	CXCL8	6LFO-CXCR2-CXCL8-Gi1/β1/γ2
3.85	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
3.85	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
3.85	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
3.85	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
3.85	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
3.85	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
3.85	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
3.85	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
3.85	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
3.85	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
3.85	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
3.85	Single	8YNF	CXCL8	8YNF-ACKR1-CXCL8
3.85	Single	8YYW	Alpha-ketoglutarate	8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
3.85	Single	9KO2	CCL19	9KO2-CCR7-CCL19-Gi1/β1
3.85	Single	9KO6	CCL19	9KO6-CCR7-CCL19
3.85	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
3.85	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
3.85	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.85	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
3.85	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.85	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
3.70	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
3.70	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.70	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
3.70	Single	7UTZ	DPPC	7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
3.70	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
3.70	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.70	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
3.70	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	9BA0	MRI-1891	9BA0-CB₁-MRI-1891
3.70	Single	9K0K	UTP	9K0K-P2Y₄-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	9K0X	ATP	9K0X-P2Y₂-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70	Single	9K20	ATP	9K20-P2Y₂-ATP-chim(NtGi1-Go)/β1/γ2
3.70	Single	9M2F	Neuropeptide-FF	9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
3.70	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
3.70	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.70	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
3.70	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
3.70	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
3.57	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
3.57	Single	5T04	Neurotensin-(8-13)	5T04-NTS₁-Neurotensin-(8-13)
3.57	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
3.57	Single	6D27	CAY10471	6D27-DP₂-CAY10471
3.57	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
3.57	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
3.57	Single	6Z4V	Neurotensin-(9-13)	6Z4V-NTS₁-Neurotensin-(9-13)
3.57	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.57	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
3.57	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
3.57	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
3.57	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
3.57	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
3.57	Single	7VIF	FTY720-P	7VIF-S1P₁-FTY720-P-Gi1/β1/γ2
3.57	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
3.57	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
3.57	Single	8IC0	CXCL8	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.57	Single	9MET	Gp120; CD4	9MET-CXCR4-Gp120; CD4
3.57	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-CXCL8-Gi1/β1/γ2
3.57	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
3.57	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
3.57	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
3.45	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
3.45	Single	5C1M	BU72	5C1M-μ-BU72
3.45	Single	6LFM	CXCL8	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
3.45	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
3.45	Single	7C4S	S1P	7C4S-S1P₃-S1P
3.45	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
3.45	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
3.45	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
3.45	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
3.45	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
3.45	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
3.45	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	8ZYT	Neurotensin-(8-13)	8ZYT-NTS₁-Neurotensin-(8-13)-SBI-553-Arrestin2
3.45	Single	9B9Z	MRI-1867	9B9Z-CB₁-MRI-1867
3.45	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
3.45	Single	9KO4	CCL21	9KO4-CCR7-CCL21-Gi1/β1/γ2
3.45	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-CXCL8-Gi1/β1/γ2
3.45	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
3.45	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
3.45	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
3.45	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
3.33	Single	3ZEV	Neurotensin-(7-13)	3ZEV-NTS₁-Neurotensin-(7-13)
3.33	Single	4BV0	Neurotensin-(7-13)	4BV0-NTS₁-Neurotensin-(7-13)
3.33	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
3.33	Single	5V56	TC114	5V56-SMO-TC114
3.33	Single	5V57	TC114	5V57-SMO-TC114
3.33	Single	6OS1	TRV026	6OS1-AT₁-TRV026
3.33	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
3.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
3.33	Single	7F1T	CCL3	7F1T-CCR5-CCL3
3.33	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
3.33	Single	7L0P	Neurotensin-(8-13)	7L0P-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.33	Single	7L0Q	Neurotensin-(8-13)	7L0Q-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.33	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
3.33	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
3.33	Single	7T9N	DPPC	7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
3.33	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
3.33	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
3.33	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
3.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
3.33	Single	8FMZ	Neurotensin-(8-13)	8FMZ-NTS₁-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33	Single	8FN1	Neurotensin-(8-13)	8FN1-NTS₁-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
3.33	Single	8HQC	C5a	8HQC-C5a₁-C5a-Go/β1/γ2
3.33	Single	8I2G	PubChem 67530240	8I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
3.33	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
3.33	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
3.33	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8JZP	C5a	8JZP-C5a₁-C5a-Go/β1/γ2
3.33	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
3.33	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
3.33	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
3.33	Single	9IZG	LPA	9IZG-LPA₁-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	9JCL	ADP	9JCL-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
3.33	Single	9L16	CCL21	9L16-CCR7-CCL21
3.33	Single	9MEN	Gp120 (V3 loop)	9MEN-CXCR4-Gp120 (V3 loop)
3.33	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
3.33	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
3.33	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
3.33	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
3.33	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
3.33	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.33	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
3.33	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
3.33	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
3.23	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
3.23	Single	4XEE	Neurotensin-(8-13)	4XEE-NTS₁-Neurotensin-(8-13)
3.23	Single	4XES	Neurotensin-(8-13)	4XES-NTS₁-Neurotensin-(8-13)
3.23	Single	6OS0	Angiotensin II	6OS0-AT₁-Angiotensin II
3.23	Single	6OS2	TRV026	6OS2-AT₁-TRV026
3.23	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
3.23	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
3.23	Single	6YVR	Neurotensin-(6-13)	6YVR-NTS₁-Neurotensin-(6-13)
3.23	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
3.23	Single	7EW2	FTY720-P	7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
3.23	Single	7L0S	Neurotensin-(8-13)	7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.23	Single	7W0N	Elabela	7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
3.23	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.23	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
3.23	Single	8T3Q	Doconexent	8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23	Single	8U26	Substance-P	8U26-NK₁-Substance-P-Gs/β1/γ2
3.23	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
3.23	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
3.23	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
3.23	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
3.23	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
3.23	Single	9ECJ	S-geranylgeranyl-L-glutathione	9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
3.23	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
3.23	Single	9VIF	Neuropeptide-VF	9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
3.23	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
3.23	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
3.23	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
3.23	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
3.23	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.23	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
3.23	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
3.23	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
3.23	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
3.23	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
3.23	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
3.23	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
3.23	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
3.23	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.23	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.23	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
3.12	Single	4BUO	Neurotensin-(8-13)	4BUO-NTS₁-Neurotensin-(8-13)
3.12	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
3.12	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
3.12	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
3.12	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
3.12	Single	6UP7	Neurotensin-(8-13)	6UP7-NTS₁-Neurotensin-(8-13)-Arrestin2
3.12	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
3.12	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
3.12	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
3.12	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
3.12	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
3.12	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
3.12	Single	8E0G	BU72	8E0G-μ-BU72
3.12	Single	8FN0	Neurotensin-(8-13)	8FN0-NTS₁-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
3.12	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
3.12	Single	8JPF	Neurotensin-(8-13)	8JPF-NTS₁-Neurotensin-(8-13)-SBI-553
3.12	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
3.12	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
3.12	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
3.12	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
3.12	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
3.12	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12	Single	9C0K	Exendin-4	9C0K-GLP-1-Exendin-4-Gs/β1/γ2
3.12	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.12	Single	9IZF	LPA	9IZF-LPA₁-LPA-Gi1/β1/γ2
3.12	Single	9KWX	C5a-des-Arg	9KWX-C5a₁-C5a-des-Arg-Go/β1/γ2
3.12	Single	9UYM	Chemerin-9	9UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
3.12	Single	9WP9	S1P	9WP9-S1P₃-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
3.12	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.12	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03	Single	5VBL	AMG3054	5VBL-Apelin-AMG3054
3.03	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
3.03	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
3.03	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.03	Single	7RKF	CX3CL1	7RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
3.03	Single	7RKN	CX3CL1	7RKN-US28-CX3CL1-Gi1/β1/γ2
3.03	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
3.03	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
3.03	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
3.03	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
3.03	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.03	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs/β1/γ2
3.03	Single	8XQJ	JN241	8XQJ-Apelin; Apelin-JN241
3.03	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
3.03	Single	9KX6	C5a-des-Arg	9KX6-C5a₁-C5a-des-Arg-Go/β1/γ2
3.03	Single	9UMJ	EP54	9UMJ-C3a_B-EP54-Go/β1/γ2
3.03	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
3.03	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
3.03	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
3.03	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
3.03	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
2.94	Single	4XT1	CX3CL1	4XT1-US28-CX3CL1
2.94	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
2.94	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
2.94	Single	7L0R	Neurotensin-(8-13)	7L0R-NTS₁-Neurotensin-(8-13)-Gi1/β1/γ1
2.94	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
2.94	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
2.94	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
2.94	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
2.94	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
2.94	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Gi1/β1/γ2
2.94	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
2.94	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
2.94	Single	8YWF	Retatrutide	8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.94	Single	9BUE	Cagrilintide	9BUE-CT-Cagrilintide-Gs/β1/γ2
2.94	Single	9KWG	C5a	9KWG-C5a₁-C5a-Go/β1/γ2
2.94	Single	9L3Y	Chemerin	9L3Y-CML2-Chemerin-Gi1/β1/γ2
2.94	Single	9MEJ	Gp120	9MEJ-CXCR4-Gp120
2.94	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
2.94	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
2.94	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
2.94	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.94	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
2.94	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
2.94	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
2.94	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
2.94	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
2.86	Single	6DO1	(Sar1,Ile8)-Angiotensin II	6DO1-AT₁-(Sar1,Ile8)-Angiotensin II
2.86	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
2.86	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
2.86	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
2.86	Single	7F1Q	CCL3	7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.86	Single	7PIV	Afamelanotide	7PIV-MC₄-Afamelanotide-Gs/β1/γ2
2.86	Single	7RKM	CX3CL1	7RKM-US28-CX3CL1-Gi1/β1/γ2
2.86	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
2.86	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
2.86	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
2.86	Single	7VBI	Tirzepatide (non-acylated)	7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.86	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
2.86	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.86	Single	8JZZ	C5a-des-Arg	8JZZ-C5a₁-C5a-des-Arg-Go/β1/γ2
2.86	Single	8Z7J	JN241-9	8Z7J-Apelin-JN241-9-Gi1/β1/γ2
2.86	Single	9ME1	CXCL12	9ME1-CXCR4-CXCL12
2.86	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
2.86	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
2.86	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
2.86	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM-5541-Gi1/β1/γ2 7EW2-S1P₃-FTY720-P-Gi1/β1/γ2
2.86	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
2.78	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
2.78	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
2.78	Single	6MEO	Gp160; CD4	6MEO-CCR5-Gp160; CD4
2.78	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
2.78	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
2.78	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.78	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
2.78	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
2.78	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78	Single	8K6N	Neuropeptide-Y	8K6N-Y₂-Neuropeptide-Y-Gi2/β1/γ1
2.78	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
2.78	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
2.78	Single	8XZH	MM07	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
2.78	Single	8YFO	Ac-LA-PTH Analog	8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.78	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
2.78	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
2.78	Single	9LXR	LA-PTH Analog	9LXR-PTH1-LA-PTH Analog-Arrestin2
2.78	Single	9M1O	Neuropeptide-FF	9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
2.78	Single	9MEU	CXCL12	9MEU-CXCR4-CXCL12
2.78	Single	9U4W	Gonadoliberin-1	9U4W-GnRH₁-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
2.78	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
2.78	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
2.78	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
2.78	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
2.78	Consensus	class-b1_class-b2_cons_on	Orthosteric Ligand	class-b1_on class-b2_on
2.78	Consensus	class-b1_class-b2_cons_on_gp	Orthosteric Ligand	class-b1_on_gp class-b2_on_gp
2.78	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
2.78	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
2.78	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.78	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.70	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
2.70	Single	6M1I	PACAP27	6M1I-PAC₁-PACAP27-Gs/β1/γ2
2.70	Single	6MET	Gp160; CD4	6MET-CCR5-Gp160; CD4
2.70	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
2.70	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
2.70	Single	7F6G	(Sar1)-Angiotensin II	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
2.70	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
2.70	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
2.70	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
2.70	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.70	Single	8XZJ	WN353	8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
2.70	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
2.70	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
2.70	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
2.70	Single	9BLC	Cagrilintide (non-acylated)	9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.70	Single	9BUD	Cagrilintide	9BUD-CT-Cagrilintide-Gs/β1/γ2
2.70	Single	9EBO	GLP-1 (ACPC18)	9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
2.70	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
2.70	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
2.70	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.70	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
2.70	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
2.70	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-(Sar1)-Angiotensin II-Gq/β1/γ2
2.70	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
2.70	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
2.70	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
2.70	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
2.70	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
2.70	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
2.70	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
2.70	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
2.70	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
2.70	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
2.63	Single	5YQZ	NNC1702	5YQZ-Glucagon-NNC1702
2.63	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
2.63	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
2.63	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
2.63	Single	7F9Y	Ghrelin	7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
2.63	Single	7P02	Substance-P	7P02-NK₁-Substance-P-chim(NtGi1-Gs)/β1/γ2
2.63	Single	7TYH	Calcitonin	7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
2.63	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
2.63	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
2.63	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
2.63	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.63	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.63	Single	7Y64	C5a	7Y64-C5a₁-C5a-Gi1/β1/γ2
2.63	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
2.63	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
2.63	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63	Single	8HK5	C5a	8HK5-C5a₁-C5a-Gi1/β1/γ2
2.63	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
2.63	Single	8IA2	C5a	8IA2-C5a₁-C5a-Go/β1/γ2
2.63	Single	8XQE	Apelin-13	8XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
2.63	Single	8YG4	LA-PTH Analog	8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
2.63	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
2.63	Single	9E2A	GLP-1	9E2A-GLP-1-GLP-1-Gs/β1/γ2
2.63	Single	9JFY	Neuropeptide-SF	9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
2.63	Consensus	calcitonin_on	Orthosteric Ligand	ctlike_on
2.63	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
2.63	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
2.63	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
2.63	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
2.63	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
2.63	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
2.63	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
2.63	Consensus	pac_on	Orthosteric Ligand	pac1_on
2.63	Consensus	vpac1_on	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
2.63	Consensus	vpac_on	Orthosteric Ligand	vpac1_on vpac2_on
2.56	Single	4XT3	CX3CL1	4XT3-US28-CX3CL1
2.56	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
2.56	Single	6FJ3	PTH	6FJ3-PTH1-PTH
2.56	Single	6NBF	LA-PTH Analog	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56	Single	6NBI	LA-PTH Analog	6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
2.56	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
2.56	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
2.56	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
2.56	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
2.56	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
2.56	Single	7VAB	Tirzepatide (non-acylated)	7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
2.56	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
2.56	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.56	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
2.56	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
2.56	Single	9BLB	Cagrilintide (non-acylated)	9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
2.56	Single	9BLW	Cagrilintide (non-acylated)	9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
2.56	Single	9BP3	Cagrilintide	9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
2.56	Single	9BUB	Cagrilintide	9BUB-CT-Cagrilintide-Gs/β1/γ2
2.56	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
2.56	Single	9P92	VIP	9P92-PAC₁-VIP-Gs/β1/γ2
2.56	Consensus	calcitonin_on_gp	Orthosteric Ligand	ctlike_on_gp
2.56	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
2.56	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.56	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
2.56	Consensus	crf2_on_gp	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.56	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.56	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-C5a-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a-Gi1/β1/γ2 7Y64-C5a₁-C5a-Gi1/β1/γ2
2.56	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
2.56	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
2.56	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
2.56	Consensus	pac1_on	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
2.56	Consensus	pac1_on_gp	Orthosteric Ligand	8E3X-PAC₁-PACAP27-Gs/β1/γ2 6M1H-PAC₁-Maxadilan-Gs/β1/γ2
2.56	Consensus	pac_on_gp	Orthosteric Ligand	pac1_on_gp
2.56	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
2.56	Consensus	vpac1_on_gp	Orthosteric Ligand	8E3Z-VPAC₁-VIP-Gs/β1/γ2
2.56	Consensus	vpac_on_gp	Orthosteric Ligand	vpac1_on_gp vpac2_on_gp
2.50	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
2.50	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
2.50	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
2.50	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
2.50	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
2.50	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
2.50	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
2.50	Single	7S1M	Exendin-4-D-Ala	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
2.50	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
2.50	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
2.50	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
2.50	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
2.50	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.50	Single	8FU6	ZP3780	8FU6-Glucagon-ZP3780-Gs/β1/γ2
2.50	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
2.50	Single	8ZH8	QRFP26	8ZH8-QRFP-QRFP26-Gq/β1/γ1
2.50	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
2.50	Single	9BUC	Cagrilintide	9BUC-CT-Cagrilintide-Gs/β1/γ2
2.50	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
2.50	Single	9P94	PACAP27	9P94-PAC₁-PACAP27-Gs/β1/γ2
2.50	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
2.50	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50	Consensus	glp2_on_gp	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/β1/γ2
2.50	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.50	Consensus	glp_on_gp	Orthosteric Ligand	glp1_on_gp glp2_on_gp
2.50	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
2.50	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.50	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.50	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
2.50	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
2.44	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
2.44	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
2.44	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
2.44	Single	6NBH	LA-PTH Analog	6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
2.44	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
2.44	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
2.44	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
2.44	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.44	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
2.44	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
2.44	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
2.44	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
2.44	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.44	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
2.44	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
2.44	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.44	Single	9BQ3	Cagrilintide	9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
2.44	Single	9BTW	Cagrilintide	9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
2.44	Single	9BYO	Exendin-3	9BYO-GLP-1-Exendin-3-Gs/β1/γ2
2.44	Single	9P93	VIP	9P93-PAC₁-VIP-Gs/β1/γ2
2.44	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
2.44	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
2.44	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
2.44	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
2.44	Consensus	ctlike_on_gp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.44	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.44	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
2.44	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
2.44	Consensus	pth1_on	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.44	Consensus	vip-pacap_on	Orthosteric Ligand	vpac_on pac_on
2.44	Consensus	vip-pacap_on_gp	Orthosteric Ligand	vpac_on_gp pac_on_gp
2.44	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
2.44	Consensus	vpac2_on_gp	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
2.38	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.38	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.38	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
2.38	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.38	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
2.38	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
2.38	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
2.38	Consensus	class-a_class-b1_cons_on	Orthosteric Ligand	class-a_on class-b1_on
2.38	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
2.38	Consensus	gip_on	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38	Consensus	gip_on_gp	Orthosteric Ligand	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
2.38	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
2.38	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
2.33	Single	6LPB	PACAP27	6LPB-PAC₁-PACAP27-Gs/β1/γ1
2.33	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
2.33	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
2.33	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
2.33	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.33	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.33	Single	8FLU	LA-PTH Analog	8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
2.33	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.33	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
2.33	Consensus	glp1_on	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.33	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
2.33	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
2.27	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.27	Single	6WPW	ZP3780	6WPW-Glucagon-ZP3780-Gs/β1/γ2
2.27	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.27	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
2.27	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
2.27	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
2.27	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.27	Consensus	crf_on_gp	Orthosteric Ligand	crf2_on_gp crf1_on_gp
2.27	Consensus	glp1_on_gp	Orthosteric Ligand	7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
2.27	Consensus	pth1_on_gp	Orthosteric Ligand	6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
2.22	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
2.22	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
2.22	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
2.22	Single	7Y36	PTH	7Y36-PTH1-PTH-Gs/β1/γ2
2.22	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
2.22	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
2.22	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
2.22	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.22	Consensus	class-a_class-b1_cons_on_gp	Orthosteric Ligand	class-a_on_gp class-b1_on_gp
2.22	Consensus	glucagon_on	Orthosteric Ligand	glp_on gluc_on secretin_on gip_on
2.22	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.17	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
2.17	Consensus	gluc_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.17	Consensus	glucagon_on_gp	Orthosteric Ligand	glp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
2.17	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
2.13	Consensus	gluc_on_gp	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
2.13	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.13	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
2.08	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
2.08	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on vip-pacap_on pth_on crf_on calcitonin_on
2.08	Consensus	pth2_on_gp	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/β1/γ2
2.04	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
2.00	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.00	Consensus	pth_on_gp	Orthosteric Ligand	pth1_on_gp pth2_on_gp
1.92	Consensus	class-b1_on_gp	Orthosteric Ligand	glucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
1.89	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB	8XFP
Class	A
SubFamily	Orphan
Type	Orphan
SubType	LGR4
Species	Homo Sapiens
Ligand	R-spondin-2
Other Ligand(s)	-
Protein Partners	ZNRF3; ZNRF3
PDB Resolution	3.21
Date	2024-12-04
D.O.I.	doi.org/10.1038/s41467-024-55431-3

Net Summary
I_min	1.7
Number of Linked Nodes	1216
Number of Links	1616
Number of Hubs	309
Number of Links mediated by Hubs	1029
Number of Communities	36
Number of Nodes involved in Communities	456
Number of Links involved in Communities	707

Path Summary
Number Of Nodes in MetaPath	155
Number Of Links MetaPath	154
Number of Shortest Paths	35124060
Length Of Smallest Path	3
Average Path Length	86.9214
Length of Longest Path	87
Minimum Path Strength	1.26
Average Path Strength	8.00478
Maximum Path Strength	24.625
Minimum Path Correlation	0.72
Average Path Correlation	1
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	1.75439
Average % Of Corr. Nodes	64.7942
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	128
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• aminoacyltransferase activity • ubiquitin-like protein transferase activity • catalytic activity, acting on a protein • acyltransferase activity • transferase activity • catalytic activity • ubiquitin-protein transferase activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • binding • metal ion binding • small molecule binding • ubiquitin-like protein ligase activity • ubiquitin protein ligase activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • catabolic process • primary metabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • developmental process • multicellular organism development • multicellular organismal process
Gene Ontology	Biological Process	• catabolic process • primary metabolic process • protein catabolic process • macromolecule catabolic process • modification-dependent macromolecule catabolic process • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • metabolic process • cellular process • protein metabolic process • macromolecule metabolic process • developmental process • multicellular organism development • multicellular organismal process • limb development • appendage development • anatomical structure development • stem cell proliferation • cell population proliferation • regulation of Wnt signaling pathway, planar cell polarity pathway • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • regulation of Wnt signaling pathway • cell surface receptor signaling pathway • response to stimulus • signaling • biological regulation • regulation of signal transduction • Wnt signaling pathway, planar cell polarity pathway • regulation of non-canonical Wnt signaling pathway • cell communication • regulation of response to stimulus • regulation of cell communication • non-canonical Wnt signaling pathway • signal transduction • Wnt signaling pathway • receptor catabolic process • negative regulation of signaling • negative regulation of biological process • negative regulation of cell communication • negative regulation of Wnt signaling pathway • receptor metabolic process • negative regulation of cellular process • negative regulation of response to stimulus • negative regulation of signal transduction • Wnt receptor catabolic process • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • negative regulation of canonical Wnt signaling pathway • protein ubiquitination • macromolecule modification • post-translational protein modification • protein modification process • protein modification by small protein conjugation • protein modification by small protein conjugation or removal • negative regulation of non-canonical Wnt signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • signaling receptor binding • BMP receptor binding • receptor serine/threonine kinase binding • transmembrane receptor protein serine/threonine kinase binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • regulation of animal organ morphogenesis • regulation of developmental process • regulation of odontogenesis of dentin-containing tooth • negative regulation of developmental process • regulation of odontogenesis • odontogenesis of dentin-containing tooth • odontogenesis • animal organ development • negative regulation of odontogenesis • anatomical structure morphogenesis • negative regulation of odontogenesis of dentin-containing tooth • animal organ morphogenesis • negative regulation of animal organ morphogenesis • regulation of multicellular organismal process • negative regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • cellular developmental process • ossification • cell differentiation • osteoblast differentiation • lung growth • developmental growth • tube development • growth • respiratory tube development • organ growth • lung development • respiratory system development • system development • trachea cartilage morphogenesis • connective tissue development • trachea cartilage development • trachea morphogenesis • tissue development • tissue morphogenesis • skeletal system development • trachea development • cartilage morphogenesis • cartilage development • embryonic forelimb morphogenesis • embryonic limb morphogenesis • embryonic morphogenesis • embryonic appendage morphogenesis • embryo development • forelimb morphogenesis • appendage morphogenesis • limb morphogenesis • bone mineralization • biomineral tissue development • branching morphogenesis of an epithelial tube • tube morphogenesis • lung morphogenesis • epithelial tube morphogenesis • epithelium development • morphogenesis of an epithelium • morphogenesis of a branching structure • epithelial tube branching involved in lung morphogenesis • morphogenesis of a branching epithelium • embryonic hindlimb morphogenesis • hindlimb morphogenesis • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • positive regulation of response to stimulus • positive regulation of Wnt signaling pathway • positive regulation of cellular process • positive regulation of signaling • positive regulation of canonical Wnt signaling pathway • dopaminergic neuron differentiation • nervous system development • generation of neurons • neurogenesis • neuron differentiation • cell surface • extracellular region • extracellular space • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • protein-hormone receptor activity • tissue remodeling • bone remodeling • renal system development • epithelial cell proliferation involved in renal tubule morphogenesis • renal tubule development • epithelial cell proliferation • renal tubule morphogenesis • positive regulation of response to biotic stimulus • pattern recognition receptor signaling pathway • toll-like receptor signaling pathway • response to biotic stimulus • immune response-activating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • innate immune response-activating signaling pathway • immune response • response to other organism • regulation of innate immune response • response to external stimulus • defense response to other organism • regulation of pattern recognition receptor signaling pathway • positive regulation of defense response • activation of innate immune response • regulation of immune response • regulation of toll-like receptor signaling pathway • activation of immune response • regulation of defense response • regulation of response to biotic stimulus • biological process involved in interspecies interaction between organisms • regulation of response to external stimulus • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of response to stress • response to stress • innate immune response • response to external biotic stimulus • positive regulation of innate immune response • defense response • defense response to symbiont • negative regulation of toll-like receptor signaling pathway • negative regulation of immune system process • immune system process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • mesonephric epithelium development • kidney epithelium development • nephron tubule morphogenesis • regulation of kidney development • regulation of branching involved in ureteric bud morphogenesis • positive regulation of developmental process • nephron development • regulation of morphogenesis of a branching structure • positive regulation of multicellular organismal process • mesonephric tubule development • nephron morphogenesis • nephron epithelium morphogenesis • nephron tubule development • ureteric bud morphogenesis • positive regulation of morphogenesis of an epithelium • branching involved in ureteric bud morphogenesis • regulation of morphogenesis of an epithelium • nephron epithelium development • ureteric bud development • mesonephros development • kidney morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis • mesonephric tubule morphogenesis • kidney development • digestive system development • digestive tract development • epidermis development • molting cycle process • hair cycle • skin development • skin epidermis development • hair follicle development • molting cycle • hair cycle process • genitalia development • reproductive system development • sex differentiation • male sex differentiation • male genitalia development • reproductive structure development • multicellular organismal-level homeostasis • homeostatic process • homeostasis of number of cells • intestinal stem cell homeostasis • regulation of biosynthetic process • rhythmic process • circadian regulation of gene expression • circadian rhythm • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • regulation of metabolic process • cytokine production • regulation of cytokine production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • metanephric tubule morphogenesis • metanephric epithelium development • metanephros development • metanephros morphogenesis • metanephric nephron tubule morphogenesis • metanephric nephron development • metanephric nephron epithelium development • metanephric nephron tubule development • metanephric nephron morphogenesis • metanephric tubule development • negative regulation of cold-induced thermogenesis • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • metanephric glomerulus development • glomerulus development
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	R-spondin-2
UniProt	Q6UXX9
Sequence	>8XFP_Chain_L K G C L S C S K D N G C S R C Q Q K L F F F L R R E G M R Q Y G E C L H S C P S G Y Y G H R A P D M N R C A R C R I E N C D S C F S K D F C T K C K V G F Y L H R G R C F D E C P G F A P L D E T M E C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	M
Protein	R-spondin-2
UniProt	Q6UXX9
Sequence	>8XFP_Chain_M K G C L S C S K D N G C S R C Q Q K L F F F L R R E G M R Q Y G E C L H S C P S G Y Y G H R A P D M N R C A R C R I E N C D S C F S K D F C T K C K V G F Y L H R G R C F D E C P G F A P L D E T M E C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	E
Protein	ZNRF3
UniProt	Q9ULT6
Sequence	>8XFP_Chain_E K E T A F V E V V L F E S S P S G D Y T T Y T T G L T G R F S R A G A T L S A E G E I V Q M H P L G L C N N N D E E D L Y E Y G W V G V V K L E Q P E L D P K P C L T V L G K A K R A V Q R G A T A V I F D V S E N P E A I D Q L N Q G S E D P L K R P V V Y V K G A D A I K L M N I V N K Q K V A R A R I Q H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q9BXB1
Sequence	>8XFP_Chain_R C S C D G D R R V D C S G K G L T A V P E G L S A F T Q A L D I S M N N I T Q L P E D A F K N F P F L E E L Q L A G N D L S F I H P K A L S G L K E L K V L T L Q N N Q L K T V P S E A I R G L S A L Q S L R L D A N H I T S V P E D S F E G L V Q L R H L W L D D N S L T E V P V H P L S N L P T L Q A L T L A L N K I S S I P D F A F T N L S S L V V L H L H N N K I R S L S Q H C F D G L D N L E T L D L N Y N N L G E F P Q A I K A L P S L K E L G F H S N S I S V I P D G A F D G N P L L R T I H L Y D N P L S F V G N S A F H N L S D L H S L V I R G A S M V Q Q F P N L T G T V H L E S L T L T G T K I S S I P N N L C Q E Q K M L R T L D L S Y N N I R D L P S F N G C H A L E E I S L Q R N Q I Y Q I K E G T F Q G L I S L R I L D L S R N L I H E I H S R A F A T L G P I T N L D V S F N E L T S F P T E G L N G L N Q L K L V G N F K L K E A L A A K D F V N L R S L S V P Y A Y Q C C A F W G C S Q I I I H C T P S T G A F K P C E Y L L G S W M I R L T V W F I F L V A L F F N L L V I L T T F A S C T S L P S S K L F I G L I S V S N L F M G I Y T G I L T F L D A V S W G R F A E F G I W W E T G S G C K V A G F L A V F S S E S A I F L L M L A T V E R S L S A K D N H L K Q F R V A A L L A F L G A T V A G C F P L F H R G E Y S A S P L C L P F P T G E T P S L G F T V T L V L L N S L A F L L M A V I Y T K L Y C N L E Q S S M I K H V A W L I F T N C I F F C P V A F F S F A P L I T A I S I S P E I M K S V T L I F F P L P A C L N P V L Y V F F N P K F K E D W K L L K R R V T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	T
Protein	ZNRF3
UniProt	Q9ULT6
Sequence	>8XFP_Chain_T K E T A F V E V V L F E S S P S G D Y T T Y T T G L T G R F S R A G A T L S A E G E I V Q M H P L G L C N N N D E E D L Y E Y G W V G V V K L E Q P E L D P K P C L T V L G K A K R A V Q R G A T A V I F D V S E N P E A I D Q L N Q G S E D P L K R P V V Y V K G A D A I K L M N I V N K Q K V A R A R I Q H Q P T E Y F D M G I F L A F F V V V S L V C L I L L V K I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9KB6	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.53	2025-10-15	doi.org/10.1038/s41467-025-64129-z
	9KB7	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	-	3.97	2025-10-15	doi.org/10.1038/s41467-025-64129-z
	9KB8	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3; ZNRF3	3.25	2025-10-15	doi.org/10.1038/s41467-025-64129-z
	9KB9	A	Orphan	Orphan	LGR4; LGR4	Homo sapiens	R-spondin-2	-	ZNRF3; ZNRF3	3.59	2025-10-15	doi.org/10.1038/s41467-025-64129-z
	8WVU	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-1	-	RNF43	3.61	2024-10-30	To be published
	8WVV	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.35	2024-10-30	To be published
	8WVW	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.53	2024-10-30	To be published
	8WVX	A	Orphan	Orphan	LGR4	Homo sapiens	Norrin	-	-	3.32	2024-10-30	To be published
	8WVY	A	Orphan	Orphan	LGR4	Homo sapiens	Norrin	-	-	3.29	2024-10-30	To be published
	8XFP	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3; ZNRF3	3.21	2024-12-04	doi.org/10.1038/s41467-024-55431-3
	8XFS	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3; ZNRF3	3.2	2024-12-04	doi.org/10.1038/s41467-024-55431-3
	8XFT	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	ZNRF3	3.24	2024-12-04	doi.org/10.1038/s41467-024-55431-3
	8Y69	A	Orphan	Orphan	LGR4; LGR4	Homo sapiens	R-spondin-2	-	ZNRF3	3.38	2024-12-04	doi.org/10.1038/s41467-024-55431-3
	8XT9	A	Orphan	Orphan	LGR4	Homo sapiens	-	-	-	3.1	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XUM	A	Orphan	Orphan	LGR4	Homo sapiens	R-spondin-2	-	-	2.9	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	9KGK	A	Orphan	Orphan	LGR4	Homo sapiens	NB18	-	-	2.63	2025-07-16	To be published
	9KHH	A	Orphan	Orphan	LGR4	Homo sapiens	Norrin	-	-	3.65	2025-07-16	To be published
	9S37	A	Orphan	Orphan	LGR4	Homo sapiens	NB21	-	-	3.94	2025-07-30	To be published
	9S38	A	Orphan	Orphan	LGR4	Homo sapiens	NB21	-	-	3.94	2025-09-03	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XFP.zip

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