Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1NT.Y34 4.43438826
2NT.N46 2.92502
31x40 2.8754184
41x50 5.44375409
5I1x50 10.4215208
62x46 5.005409
72x50 6.268509
82x51 4.306254197
92x52 2.83125407
102x57 8.43667607
113x25 6.73833629
123x28 5.57571726
133x29 9.41875424
143x33 6.0675425
153x34 2.655406
163x40 3.88375428
173x42 7.83375408
183x43 4.80625408
193x49 4.3775408
203x50 6.1575139
213x51 8.433754217
223x55 11.234216
233x56 5.635225
244x42 3.19625407
25E2.I189 5.21625403
26E2.Y202 5.96286724
275x39 9.0425427
285x43 6.45625426
295x47 7.81625427
305x58 5.38625409
315x62 4.735406
326x44 9.58429
336x48 7.63929728
346x58 8.38125404
357x30 3.1875404
367x37 5.9275405
377x53 4.968336139
388x50 5.575408
398x54 3.5975406
40b.1x11 1.88125408
41b.1x12 2.47875406
42b.1x16 4.085404
43b.lh12x2 4.8575408
44b.lhb1x6 2.955503
45b.b1x6 8.36469
46b.l1x3 7.9575669
47b.b2x1 8.502588
48b.b2x5 8.11125407
49b.b3x3 3.7625408
50b.l3x2 6.1569
51b.b4x2 6.74125408
52b.b4x4 8.2025468
53b.b4x6 8.74143769
54b.b5x3 5.935669
55b.b5x7 6.048754147
56b.l5x1 4.0455148
57b.l5x5 7.78583619
58b.b6x5 4.89125406
59b.l6x5 5.13254114
60b.b7x1 6.460836114
61b.b8x1 3.93625418
62b.b8x3 3.66125406
63b.b8x4 5.435717146
64b.l8x5 2.45403
65b.l8x8 4.3615144
66b.l9x3 7.34667619
67b.l9x6 5.50563818
68b.b10x5 4.38509
69b.l10x1 3.61375403
70b.b11x4 5.73375419
71b.l11x2 8.33375419
72b.b12x6 8.47167618
73b.l12x1 3.175406
74b.b13x7 7.075547
75b.l13x3 7.83333649
76b.l13x6 5.525419
77b.b14x3 4.94625445
78b.b15x1 7.88125449
79b.b15x2 7.05436
80b.l15x2 5.849549
81b.b16x4 11.4975446
82b.b16x5 4.645405
83b.b16x6 8.35833648
84b.b17x4 5.39754295
85b.b17x7 7.9475438
86b.l17x3 9.795539
87b.l17x6 6.48419
88b.l17x7 4.8375437
89b.b18x3 4.51625438
90b.l18x1 6.5757156
91b.b19x2 6.37667636
92b.b19x4 6.27875438
93b.l19x1 5.925409
94b.l19x2 4.98409
95b.b20x2 5.58875436
96b.b20x4 11.492538
97b.b20x6 7.426536
98b.b20x7 3.6475409
99b.l20x2 6.625409
100b.b21x1 10.71437
101b.b21x7 7.015605
102b.l21x5 3.289594
103b.b22x5 6.00875407
104b.b23x2 5.1125406
105b.b23x6 6.98697
106b.b24x2 4.94125495
107b.b24x4 6.778596
108b.l24x3 5.51125405
109b.b25x3 6.91495
110b.l25x3 8.9445109
111b.b26x3 3.30375406
112b.l27x1 11.5671789
113b.l27x2 8.8954109
114b.b28x3 5.055467
115b.b28x4 8.181254106
116b.b28x6 9.5655109
117G.S1.02 4.76083655
118G.H1.01 4.1625409
119G.H1.04 3.786577
120G.H1.07 3.694509
121G.H1.08 4.80125408
122G.S2.08 8.93455
123G.S3.03 9.31125457
124G.S3.06 7.677516
125G.s3h2.03 5.529519
126G.H2.04 4.295419
127G.H2.06 5.475619
128G.H2.07 5.839519
129G.H2.09 5.86375488
130G.h2s4.01 6.754519
131G.S4.04 6.215419
132G.s4h3.04 6.9155168
133G.s4h3.08 5.08625408
134G.H3.01 8.65254319
135G.H3.09 5.22583619
136G.H3.13 4.22375415
137G.H3.14 7.2425418
138G.H3.17 7.22833684
139G.H3.18 6.473754329
140G.S5.03 2.94125478
141G.S5.05 3.87357779
142G.S5.07 4.484579
143G.HG.04 5.4765168
144G.HG.07 5.418754169
145G.HG.14 2.79125405
146G.hgh4.02 5.266878127
147G.hgh4.05 8.3325406
148G.H4.03 6.785604
149G.h4s6.02 4.8475417
150G.S6.02 6.616676247
151G.S6.03 7.54125415
152G.S6.04 8.6425479
153G.s6h5.01 5.9225479
154G.H5.03 5.95375478
155G.H5.08 5.894558
156G.H5.25 4.914137
157g.h2x11 8.46754156
158g.ctx3 5.5165309
159g.ctx6 3.58406
160g.ctx16 4.721437268
161Lig 8.029231320
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
13x25 E2.L201 12.85947.97YesNo091
25x43 6x48 39.2195.155YesYes268
35x43 Lig 38.033110.54YesYes260
43x40 6x48 42.49883.065YesYes288
53x40 5x50 46.68194.76YesNo087
63x44 5x50 45.25156.635NoNo077
73x44 5x53 45.54192.98NoNo075
85x53 5x57 45.69662.98NoNo056
93x51 5x57 45.86316.43YesNo076
103x51 3x55 45.993114.71YesYes2176
113x55 5x64 63.580613.925YesNo066
125x64 5x68 63.862614.92NoNo067
135x68 G.H5.12 64.16116.47NoNo076
14G.H5.08 G.H5.12 64.3175.835YesNo086
15G.H5.08 G.S2.08 61.59885.895YesYes585
16G.H5.04 G.S2.08 62.383310.49NoYes075
17G.H1.08 G.H5.04 62.52333.04YesNo087
18G.H1.04 G.H1.08 76.86432.92YesYes078
19G.H1.04 G.S5.07 82.84064.955YesYes779
20G.S5.07 G.s5hg.01 92.88432.1YesNo099
21G.s4h3.02 G.s5hg.01 91.39624.59NoNo099
22G.HG.07 G.s4h3.02 91.55614.59YesNo099
23G.HG.07 G.s4h3.04 91.66755.97YesYes1698
24G.HG.04 G.s4h3.04 95.01955.675YesYes1688
25G.HG.04 G.s4h3.01 95.34188.525YesNo086
26G.S5.06 G.s4h3.01 92.28918.995NoNo086
27G.S5.06 G.S6.03 93.52052.95NoYes085
28G.S5.04 G.S6.03 93.6928.11NoYes195
29G.S4.04 G.S5.04 91.69263.65YesNo199
30G.H3.08 G.S4.04 99.9726.09NoYes189
31G.H2.04 G.H3.08 99.66074.25YesNo198
32G.H2.04 G.H2.07 1006.5YesYes199
33G.H2.07 G.h2s4.01 57.10094.01YesYes199
34G.h2s4.01 b.l5x5 55.218410.02YesYes199
35b.l3x1 b.l5x5 67.19434.93NoYes099
36b.b2x1 b.l3x1 67.103714.09YesNo089
37b.b2x1 b.l27x1 65.07778.2YesYes889
38b.b26x1 b.l27x1 74.27276.175NoYes099
39b.b26x1 b.b26x2 74.12053.44NoNo097
40b.b26x2 b.b2x3 73.8156.48NoNo076
41b.b26x4 b.b2x3 73.66163.49NoNo056
42b.b26x3 b.b26x4 73.50792.565YesNo065
433x49 4x41 11.6772.91YesNo086
443x50 G.H5.25 12.02386.68YesYes1397
453x56 I2x56 11.96863.72YesNo056
464x41 I2x56 11.8627.445NoNo066
473x54 3x55 17.6083.275NoYes086
483x54 G.H5.20 17.35562.98NoNo088
49G.H5.20 G.H5.25 14.28974.15NoYes087
503x56 G.H5.19 12.29536.03YesNo058
51G.H2.07 b.l9x6 66.40544.825YesYes198
52G.H2.06 b.l9x6 45.57593.58YesYes198
53G.H2.06 b.l17x6 22.88796.22YesYes199
54b.l17x6 b.l19x1 23.11964.655YesYes099
55b.l17x5 b.l19x1 52.73374.415NoYes069
56b.l17x5 b.l19x2 52.3783.68NoYes069
57b.b20x2 b.l19x2 33.67699.395YesYes069
58b.b20x2 b.b20x4 32.18165.82YesYes368
59b.b20x4 b.b20x6 31.4785.34YesYes386
60b.b17x7 b.b20x6 19.68088.04YesYes386
61b.b17x7 b.b21x1 18.82854.78YesYes387
62b.1x19 b.b21x1 17.309913.1NoYes067
63b.1x15 b.1x19 12.66114.385NoNo076
64b.1x12 b.1x15 11.88093.635YesNo067
65G.H2.06 b.b18x1 22.76285.6YesNo099
66b.b18x1 b.l19x1 22.704112.115NoYes099
67b.b22x4 b.b26x3 68.72673NoYes056
68b.b22x4 b.b26x5 68.5614.04NoNo057
69b.b26x5 b.b27x1 68.39493.21NoNo076
70b.b27x1 g.ctx5 67.38573.725NoNo069
71g.ctx3 g.ctx5 66.76654.75YesNo3099
72g.ctx3 g.ctx6 44.34384.75YesYes096
73b.lhb1x6 g.ctx6 22.22422.98YesYes036
74b.b24x7 b.lhb1x6 21.2915.11NoYes093
75b.b24x7 b.l24x3 42.047312.445NoYes095
76b.l24x3 b.lhb1x3 40.10683.635YesNo052
77b.lhb1x3 g.h2x9 39.11923.645NoNo2524
78b.l24x2 g.h2x9 38.64742.83NoNo064
79b.h2x5 b.l24x2 37.67253.685NoNo056
80b.h2x1 b.h2x5 37.18453.685NoNo055
81b.l22x5 g.ctx6 21.4753.645NoYes096
82b.b24x7 b.l22x5 21.241814.885NoNo099
83b.b21x5 b.h2x1 35.71825.65NoNo045
84g.ctx3 g.ctx4 30.04824.83YesNo097
85b.l26x5 g.ctx4 28.847910.9NoNo057
86b.l26x3 b.l26x5 28.60676.235NoNo075
87b.l26x1 b.l26x3 28.10254.34NoNo2777
88b.b2x5 b.l26x1 27.880811.525YesNo077
89b.b2x5 b.b3x2 20.828710.82YesNo075
90b.b3x2 b.b4x6 20.57635.695NoYes059
91b.b4x6 b.l1x3 15.47173.7YesYes699
92b.l1x3 b.l3x2 14.89168.19YesYes699
93b.b4x2 b.l3x2 13.56958.3YesYes089
94b.b4x2 b.b5x8 12.76543.345YesNo085
95b.b5x7 b.b5x8 12.49653.39YesNo075
96b.l11x1 b.l9x6 49.07787.24NoYes198
97b.b11x6 b.l11x1 48.89762.785NoNo199
98b.b11x6 b.l9x3 46.643315.34NoYes199
99b.l9x3 b.l9x7 17.6983.215YesNo197
100b.b8x1 b.l9x7 17.38463.17YesNo187
101b.b10x3 b.b8x1 34.48473.64NoYes088
102b.b10x3 b.b6x2 33.83145.07NoNo088
103b.b10x2 b.b6x2 33.17773.38NoNo068
104b.b11x4 b.l9x3 17.69696.165YesYes199
105b.b11x4 b.b8x1 17.43583.38YesYes198
106b.b12x6 b.l9x3 10.1546.345YesYes189
107G.s3h2.03 b.l7x2 11.94173.99YesNo199
108b.b10x2 b.b14x3 26.56417.145NoYes065
109b.b14x3 b.b15x1 16.61133.655YesYes459
110b.b15x1 b.b16x6 11.32112.03YesYes498
111b.b19x6 b.l19x2 17.9912.945NoYes099
112b.b18x3 b.b19x4 15.34563.8YesYes388
113b.b15x2 b.b18x3 13.81055.375YesYes368
114b.b19x2 b.b20x6 11.531710.72YesYes366
115b.b15x2 b.b16x5 10.47174.47YesYes065
116b.b21x5 b.b21x7 35.228610.18NoYes045
117b.b20x5 b.b21x7 13.23296.445NoYes075
118b.b22x5 b.l18x1 10.20048.035YesYes076
119b.b21x7 b.b24x6 11.263713.985YesNo058
120b.l19x1 b.l21x8 12.32812.515YesNo094
121b.l21x8 b.l23x1 12.06422.515NoNo046
122b.l25x6 b.l27x1 10.671223.99NoYes889
123G.H5.11 G.S3.03 12.16594.585NoYes587
124G.S2.06 G.S3.03 14.017615NoYes087
125G.H5.11 G.H5.15 12.62843.07NoNo088
126G.H5.15 G.H5.19 12.41234.25NoNo088
127G.H1.08 G.S2.06 14.25017.465YesNo088
128b.l23x1 b.l25x6 11.290723.225NoNo068
129b.l5x5 b.l7x2 11.72045.695YesNo199
130G.s3h2.03 b.l9x6 11.74846.2YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NT.K39NT.Y348.362NoYes0011
NT.L41NT.Y345.8650NoYes0021
E1x50NT.Y344.372NoYes5011
3x25NT.Y342.8952YesYes9021
E2.P200NT.Y347.652NoYes0021
LigNT.Y343.3352YesYes0001
7x34NT.K394.7252NoNo4011
LigNT.K3910.032YesNo0001
1x357x358.350NoNo5421
2x572x602.930YesNo7622
2x577x389.9650YesNo7621
2x603x286.680NoYes6621
2x633x284.820NoYes5621
E1.T109E1x473.642NoNo0512
7x35E1.T1094.5052NoNo4011
E1.T109Lig6.292NoYes0010
3x28E1x504.5252YesNo6511
E1x50Lig6.842NoYes5010
3x28E1x524.862YesNo6612
3x253x2872YesYes9621
3x253x2915.332YesYes9421
3x25E2.P2003.3752YesNo9022
3x25E2.Y2023.862YesYes9022
3x28Lig6.472YesYes6010
3x29E2.Y2026.7652YesYes4012
3x29Lig10.9052YesYes4010
3x303x334.190NoYes6521
3x33E2.Y2026.92YesYes5012
3x335x396.92YesYes5712
3x33Lig6.282YesYes5010
3x374x566.0252NoNo6522
3x375x436.062NoYes6621
4x565x434.072NoYes5621
7x34E2.M19811.5052NoNo4012
5x39E2.Y2025.462YesYes7022
5x406x554.8452NoNo6611
5x40Lig3.9352NoYes6010
5x436x485.1552YesYes6812
5x43Lig10.542YesYes6010
6x55Lig3.9252NoYes6010
7x34Lig14.5352NoYes4010
7x35Lig8.532NoYes4010
7x38Lig12.7650NoYes6010
3x283x294.6752YesYes6411
NT.I30NT.Y342.420NoYes0021
NT.N35NT.Y340.580NoYes0021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
92.31Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
92.31Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
92.31Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
92.31Consensuslpa_onOrthosteric Ligandlpa1_on
92.31Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
84.62Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
80.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
80.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
78.57Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
78.57Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
76.92Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
73.33Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
71.43Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
68.75Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
63.16Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
61.11Consensuslpl_onOrthosteric Ligands1p_on lpa_on
61.11Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
56.25Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
55.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
52.94Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
52.94Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
52.94Consensuslpa_offOrthosteric Ligandlpa1_off
50.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
50.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
47.37Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
47.06Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
44.44Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
44.44Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
44.44Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
44.44Consensuslpl_offOrthosteric Ligands1p_off lpa_off
42.86Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.11Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
42.11Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
41.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
41.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
41.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
41.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
41.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
40.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
40.00Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
40.00Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
40.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
39.13Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
38.89Single3P0GBI1671073P0G-β2-BI167107
38.89Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
38.89Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
38.89Single8E0GBU728E0G-μ-BU72
38.89Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
38.10Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
37.50Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
37.50Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
37.50Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
37.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
37.50Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
37.50Single8ZRTET-18ZRT-ETB-ET-1
37.50Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
36.84Single4LDEBI1671074LDE-β2-BI167107
36.84Single4RWADIPP-NH24RWA-δ-DIPP-NH2
36.84Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
36.84Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.84Single7YITNalfurafine7YIT-κ-Nalfurafine
36.84Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single8JJ8Formoterol8JJ8-β2-Formoterol
36.84Single8JJLOlodaterol8JJL-β2-Olodaterol
36.84Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
36.84Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
36.84Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
36.36Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
36.36Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
36.36Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
36.36Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
35.71Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
35.71Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
35.71Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
35.71Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
35.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
35.29Single7BU7BI1671077BU7-β1-BI167107
35.29Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
35.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
35.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
35.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
35.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
35.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
35.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
34.78Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
34.62Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
34.62Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
34.62Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
34.62Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
34.62Single9KDFRES-701-39KDF-ETB-RES-701-3
34.48Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
33.33Single5C1MBU725C1M-μ-BU72
33.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
33.33Single6E67BI1671076E67-β2-BI167107-Gs(CT)
33.33Single7C4SS1P7C4S-S1P3-S1P
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7WC6LSD7WC6-5-HT2A-LSD
33.33Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
33.33Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8QJ2pN1628QJ2-MC4-pN162-Gs
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
33.33Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
33.33Single9HAPTolvaptan9HAP-V2-Tolvaptan
33.33Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
33.33Single9IPYJR14a9IPY-C3aB-JR14a
33.33Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
33.33Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
33.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
33.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
32.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
32.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
32.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
32.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
31.82Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
31.82Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
31.82Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
31.82Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
31.82Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.82Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
31.82Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
31.82Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
31.82Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
31.82Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
31.58Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
31.58Single4DJHJDTic4DJH-κ-JDTic
31.58Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
31.58Single5XRAAM115425XRA-CB1-AM11542
31.58Single6H7JIsoprenaline6H7J-β1-Isoprenaline
31.58Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
31.58Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
31.58Single7FEECP559407FEE-CB1-CP55940-ZCZ011
31.58Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
31.58Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
31.58Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
31.58Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
31.58Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
31.58Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
31.58Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
31.58Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
31.58Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
31.58Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
31.58Single8XVLZibotentan8XVL-ETA-Zibotentan
31.58Single8ZWFJR14a8ZWF-C3aB-JR14a
31.58Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
31.58Single9BJKNaloxone9BJK-μ-Naloxone-NAM
31.58Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
31.58Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
31.58Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.25Single3PWHZM-2413853PWH-A2A-ZM-241385
31.25Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
31.25Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single6DS0Ly2660976DS0-5-HT2B-Ly266097
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.25Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
31.25Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
31.25Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
31.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
31.25Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
31.25Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
31.03Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
31.03Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
31.03Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
31.03Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
30.77Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
30.77Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
30.43Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
30.43Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.43Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
30.43Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
30.43Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
30.43Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
30.43Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.43Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
30.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
30.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
30.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
30.00Single6KQICP559406KQI-CB1-CP55940-Org27569
30.00Single6MXTSalmeterol6MXT-β2-Salmeterol
30.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
30.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
30.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
30.00Single9DGIZ85267113509DGI-CB1-Z8526711350
30.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
30.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.00Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
30.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
30.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
29.63Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.63Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
29.63Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
29.63Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
29.41Single3REYXAC3REY-A2A-XAC
29.41Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
29.41Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
29.41Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.41Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
29.41Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
29.41Single6AQFZM-2413856AQF-A2A-ZM-241385
29.41Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
29.41Single6VI4JDTic6VI4-κ-JDTic
29.41Single7AROLUF58337ARO-A2A-LUF5833-Na
29.41Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
29.41Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.41Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
29.41Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
29.41Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
29.41Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
29.41Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
29.41Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
29.41Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.17Single3OE0CVX153OE0-CXCR4-CVX15
29.17Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.17Single6PT2KGCHM076PT2-δ-KGCHM07
29.17Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.17Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
29.17Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
29.17Consensusangiotensin_onOrthosteric Ligandat1_on
29.17Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.17Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
29.17Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
29.17Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
28.57Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
28.57Single5X93K-87945X93-ETB-K-8794
28.57Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
28.57Single6H7LDobutamine6H7L-β1-Dobutamine
28.57Single6IBLArformoterol6IBL-β1-Arformoterol
28.57Single6IGLIRL16206IGL-ETB-IRL1620
28.57Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
28.57Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.57Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
28.57Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
28.57Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
28.57Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
28.57Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
28.57Single8IY6Endothelin-18IY6-ETB-Endothelin-1
28.57Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
28.57Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
28.57Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
28.57Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
28.57Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensusbradykinin_onOrthosteric Ligandbk2_on
28.57Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
28.57Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
28.57Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
28.57Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
28.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
28.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
28.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
28.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
27.78Single2Y01Dobutamine2Y01-β1-Dobutamine
27.78Single2Y02Carmoterol2Y02-β1-Carmoterol
27.78Single2Y04Salbutamol2Y04-β1-Salbutamol
27.78Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
27.78Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
27.78Single4EJ4Naltrindole4EJ4-δ-Naltrindole
27.78Single4QIMANTA XV4QIM-SMO-ANTA XV
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
27.78Single5UENDU1725UEN-A1-DU172
27.78Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
27.78Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
27.78Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
27.78Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
27.78Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
27.78Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
27.78Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
27.78Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
27.78Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
27.78Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
27.78Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
27.78Single7UL4Alvimopan7UL4-μ-Alvimopan
27.78Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
27.78Single7V3ZCP559407V3Z-CB1-CP55940
27.78Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
27.78Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
27.78Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
27.78Single7YXAONO-54306087YXA-S1P5-ONO-5430608
27.78Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
27.78Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.78Single8JXRLSD8JXR-D1-LSD
27.78Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
27.78Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
27.78Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
27.78Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
27.78Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
27.78Consensus5ht5_onOrthosteric Ligand5ht5a_on
27.78Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Consensusa3_onOrthosteric Liganda3a_on
27.78Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
27.78Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
27.78Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
27.78Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
27.78Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
27.78Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
27.78Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
27.59Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
27.59Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.59Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single3NY9ICI118-5513NY9-β2-ICI118-551
27.27Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
27.27Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.27Single6PT3DPI-2876PT3-δ-DPI-287
27.27Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
27.27Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
27.27Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
27.27Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
27.27Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
27.27Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8X5YAstemizole8X5Y-H1-Astemizole
27.27Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
27.27Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
26.92Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
26.92Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.92Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
26.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
26.92Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.92Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
26.92Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
26.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
26.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
26.67Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.32Single2Y00Dobutamine2Y00-β1-Dobutamine
26.32Single2Y03Isoprenaline2Y03-β1-Isoprenaline
26.32Single4NTJAZD12834NTJ-P2Y12-AZD1283
26.32Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5JQHS-Carazolol5JQH-β2-S-Carazolol
26.32Single5TVNLSD5TVN-5-HT2B-LSD
26.32Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
26.32Single5XPRBosentan5XPR-ETB-Bosentan
26.32Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
26.32Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.32Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
26.32Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.32Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.32Single6TP6Filorexant6TP6-OX1-Filorexant
26.32Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.32Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
26.32Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
26.32Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.32Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
26.32Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
26.32Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
26.32Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
26.32Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.32Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.32Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
26.32Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
26.32Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.32Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.32Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.32Single8JXSPF-61428JXS-D1-PF-6142
26.32Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
26.32Single8TF5Oleic acid8TF5-GPR6-Oleic acid
26.32Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
26.32Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9EHSLUF76029EHS-A3A-LUF7602
26.32Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
26.32Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
26.32Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.32Consensusa3_on_gpOrthosteric Liganda3a_on_gp
26.32Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.32Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
26.32Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
26.32Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
26.32Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
26.32Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.32Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.32Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
26.32Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.32Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.32Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
26.09Single4IARErgotamine4IAR-5-HT1B-Ergotamine
26.09Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
26.09Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
26.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.09Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
26.09Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.09Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.09Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
26.09Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.09Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
26.09Single8WDTphotoNECA8WDT-A2A-photoNECA
26.09Single8WKYPG-9348WKY-MC4-PG-934
26.09Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
26.09Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
26.09Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
26.09Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.09Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
25.93Single4XT3Fractalkine4XT3-US28-Fractalkine
25.93Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
25.93Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.93Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
25.93Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
25.81Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Single3QAKUK-4320973QAK-A2A-UK-432097
25.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
25.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
25.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
25.00Single5V56TC1145V56-SMO-TC114
25.00Single5XR8AM8415XR8-CB1-AM841
25.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
25.00Single6HLLCP999946HLL-NK1-CP99994
25.00Single6LI0C176LI0-GPR52-C17
25.00Single6OS1TRV0266OS1-AT1-TRV026
25.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
25.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single6WGTLSD6WGT-5-HT2A-LSD
25.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
25.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
25.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
25.00Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
25.00Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
25.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
25.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
25.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
25.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
25.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
25.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
25.00Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
25.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
25.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
25.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
25.00Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
25.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusa2_onOrthosteric Liganda2b_on
25.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
25.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.00Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
25.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
25.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
25.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
25.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
25.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
25.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
25.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
25.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusneurotensin_onOrthosteric Ligandnts1_on
25.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
24.14Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.00Single6W25SHU91196W25-MC4-SHU9119-Ca
24.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
24.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
24.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
24.00Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
24.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
24.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
23.81Single4AMIBucindolol4AMI-β1-Bucindolol
23.81Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single4PY02MeSATP4PY0-P2Y12-2MeSATP
23.81Single4XEENeurotensin4XEE-NTS1-Neurotensin
23.81Single4XESNeurotensin4XES-NTS1-Neurotensin
23.81Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
23.81Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
23.81Single6CM4Risperidone6CM4-D2-Risperidone
23.81Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
23.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.81Single6OS2TRV0266OS2-AT1-TRV026
23.81Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
23.81Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.81Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
23.81Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
23.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
23.81Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
23.81Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
23.81Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.81Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.81Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
23.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
23.81Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
23.81Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
23.81Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
23.81Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
23.81Single8JWY2-1188JWY-A2A-2-118
23.81Single8JWZAB9288JWZ-A2A-AB928-Na
23.81Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.81Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
23.81Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
23.81Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.81Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
23.81Consensusalpha1_offOrthosteric Ligandalpha1a_off
23.81Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
23.81Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
23.81Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
23.81Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
23.81Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
23.81Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
23.81Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.81Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.81Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.81Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
23.81Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
23.81Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
23.81Consensusorexin_onOrthosteric Ligandox2_on
23.81Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
23.81Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.53Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
23.53Single5WS3EMPA5WS3-OX2-EMPA
23.53Single6AKXA4R6AKX-CCR5-A4R
23.53Single6B73MP11046B73-κ-MP1104
23.53Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
23.53Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
23.53Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
23.53Single6TODEMPA6TOD-OX1-EMPA-Na
23.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
23.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
23.53Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
23.53Single7XRRLemborexant7XRR-OX2-Lemborexant
23.53Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
23.53Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
23.53Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
23.53Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
23.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.53Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
23.53Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
23.53Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
23.53Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
23.53Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
23.53Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
23.53Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
23.53Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
23.53Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
23.53Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.53Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.53Consensusorexin_offOrthosteric Ligandox2_off ox1_off
23.53Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
23.53Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
23.33Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
23.08Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
23.08Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.08Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
23.08Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
23.08Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
23.08Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
23.08Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
23.08Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
23.08Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.08Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
23.08Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
23.08Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
23.08Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
23.08Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
23.08Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
22.73Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
22.73Single4BUONeurotensin4BUO-NTS1-Neurotensin
22.73Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.73Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
22.73Single6K1QIRL25006K1Q-ETB-IRL2500
22.73Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
22.73Single7EZCUKA7EZC-A2A-UKA
22.73Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
22.73Single7UM4AS26747237UM4-5-HT5A-AS2674723
22.73Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
22.73Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
22.73Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
22.73Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
22.73Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
22.73Single8ZPLHF511168ZPL-CXCR4-HF51116
22.73Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
22.73Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
22.73Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.73Consensusendothelin_offOrthosteric Ligandetb_off
22.73Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
22.73Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
22.22Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
22.22Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
22.22Single4MBSMaraviroc4MBS-CCR5-Maraviroc
22.22Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
22.22Single4ZJCSB-6740424ZJC-OX1-SB-674042
22.22Single5IU7Q274563465IU7-A2A-Q27456346-Na
22.22Single5JTBZM-2413855JTB-A2A-ZM-241385
22.22Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
22.22Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.22Single6IQLL7458706IQL-D4-L745870
22.22Single6KUXRS-799486KUX-α2a-RS-79948
22.22Single6MH8ZM-2413856MH8-A2A-ZM-241385
22.22Single6PS0S-Carazolol6PS0-β2-S-Carazolol
22.22Single6PS4ICI118-5516PS4-β2-ICI118-551
22.22Single6PS5S-Propranolol6PS5-β2-S-Propranolol
22.22Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
22.22Single6TP3Nemorexant6TP3-OX1-Nemorexant
22.22Single6TPGEMPA6TPG-OX2-EMPA
22.22Single6TPNHTL66416TPN-OX2-HTL6641
22.22Single6V9SGTPL114036V9S-OX1-GTPL11403
22.22Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
22.22Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
22.22Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
22.22Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7T32ZM-2413857T32-A2A-ZM-241385
22.22Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.22Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
22.22Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
22.22Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
22.22Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
22.22Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
22.22Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
22.22Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
22.22Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single8K2WAMG4878K2W-CXCR3-AMG487
22.22Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
22.22Single8RLNLUF58348RLN-A2A-LUF5834
22.22Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
22.22Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
22.22Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
22.22Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
22.22Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
22.22Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
22.22Single9ARXSerotonin9ARX-5-HT2A-Serotonin
22.22Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
22.22Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
22.22Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
22.22Consensusa2_offOrthosteric Liganda2a_off
22.22Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
22.22Consensusalpha1_onOrthosteric Ligandalpha1a_on
22.22Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
22.22Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
22.22Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
22.22Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
22.22Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
22.22Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
22.22Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.22Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
21.74Single4UG2CGS216804UG2-A2A-CGS21680
21.74Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
21.74Single5WF6UK-4320975WF6-A2A-UK-432097
21.74Single5ZTYAM102575ZTY-CB2-AM10257
21.74Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
21.74Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
21.74Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
21.74Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
21.74Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single7SK9CCX6627SK9-ACKR3-CCX662
21.74Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
21.74Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
21.74Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
21.74Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
21.74Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
21.74Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
21.74Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.74Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
21.74Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
21.74Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_onOrthosteric Ligandkiss1_on
21.74Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.43Single7SK3CXCL127SK3-ACKR3-CXCL12
21.43Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.43Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
21.43Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.43Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
21.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.43Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.21Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
21.05Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
21.05Single3EMLZM-2413853EML-A2A-ZM-241385
21.05Single3NY8ICI118-5513NY8-β2-ICI118-551
21.05Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
21.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
21.05Single4GBRS-Carazolol4GBR-β2-S-Carazolol
21.05Single4QKX35V4QKX-β2-35V
21.05Single5DHGC-355DHG-NOP-C-35
21.05Single5DHHSB-6121115DHH-NOP-SB-612111
21.05Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
21.05Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6DRXLisuride6DRX-5-HT2B-Lisuride
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6H7MSalbutamol6H7M-β1-Salbutamol
21.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
21.05Single6PS1Timolol6PS1-β2-Timolol
21.05Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
21.05Single6S0LZM-2413856S0L-A2A-ZM-241385
21.05Single6TOTLemborexant6TOT-OX1-Lemborexant
21.05Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
21.05Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
21.05Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
21.05Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
21.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
21.05Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
21.05Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
21.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.05Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
21.05Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
21.05Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
21.05Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
21.05Single7WC7Lisuride7WC7-5-HT2A-Lisuride
21.05Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.05Single8CU6LJ-45178CU6-A2A-LJ-4517
21.05Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
21.05Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
21.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
21.05Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
21.05Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
21.05Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
21.05Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
21.05Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
21.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
21.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
21.05Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
21.05Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
21.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
21.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
21.05Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
21.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
21.05Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
21.05Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
21.05Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
21.05Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
21.05Single9CHXS-Carazolol9CHX-β2-S-Carazolol
21.05Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.05Single9H37A1IR09H37-A2A-A1IR0-Na
21.05Single9IYAONO-97105319IYA-GPR55-ONO-9710531
21.05Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
21.05Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
21.05Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
21.05Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
21.05Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
21.05Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
21.05Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
21.05Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.05Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.05Consensusblt_onOrthosteric Ligandblt1_on
21.05Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
21.05Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
21.05Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.05Consensusdopamine_offOrthosteric Ligandd2_off d3_off
21.05Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
21.05Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
21.05Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.05Consensusleukotriene_onOrthosteric Ligandblt_on
21.05Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
20.83Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.83Single4XT1Fractalkine4XT1-US28-Fractalkine
20.83Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.83Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.83Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
20.83Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.83Single8XWNCXCL88XWN-CXCR2-CXCL8
20.83Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
20.83Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.83Single9M4TSilodosin9M4T-Alpha1A-Silodosin
20.83Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
20.83Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.83Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.83Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.83Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.83Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.83Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
20.69Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
20.69Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.69Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
20.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
20.00Single3OE8IT1t3OE8-CXCR4-IT1t
20.00Single4JKVTaladegib4JKV-SMO-Taladegib
20.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
20.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
20.00Single5N2SPSB365N2S-A1-PSB36
20.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
20.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
20.00Single5WQCEMPA5WQC-OX2-EMPA
20.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6HLOAprepitant6HLO-NK1-Aprepitant
20.00Single6HLPNetupitant6HLP-NK1-Netupitant
20.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6Z4SSR486926Z4S-NTS1-SR48692
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7SINNPS-21437SIN-CaS-NPS-2143
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
20.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GNEKW-63568GNE-A2A-KW-6356-Na
20.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
20.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
20.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
20.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
20.00Single8S4DCMF-0198S4D-Apelin-CMF-019
20.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
20.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
20.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
20.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
20.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
20.00Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
20.00Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
20.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
20.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
20.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
20.00Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
20.00Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
20.00Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
20.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
20.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
20.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
20.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
20.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
20.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
20.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
20.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
20.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.00Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
20.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
20.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
19.44Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
19.44Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
19.35Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
19.35Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.35Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.35Consensusbombesin_onOrthosteric Ligandbb2_on
19.35Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
19.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.23Single5WF5UK-4320975WF5-A2A-UK-432097
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
19.23Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
19.23Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
19.23Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.23Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
19.23Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
19.23Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
19.23Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
19.23Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
19.23Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.23Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
19.23Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
19.05Single2YDVNECA2YDV-A2A-NECA
19.05Single4UHRCGS216804UHR-A2A-CGS21680
19.05Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
19.05Single5D5AS-Carazolol5D5A-β2-S-Carazolol
19.05Single5D5BS-Carazolol5D5B-β2-S-Carazolol
19.05Single5G53NECA5G53-A2A-NECA-Gs
19.05Single5TZRMK86665TZR-FFA1-MK8666
19.05Single5V57TC1145V57-SMO-TC114
19.05Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
19.05Single6E59L-7607356E59-NK1-L-760735
19.05Single6J20Aprepitant6J20-NK1-Aprepitant
19.05Single6J21Aprepitant6J21-NK1-Aprepitant
19.05Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
19.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
19.05Single6TQ7SB-3348676TQ7-OX1-SB-334867
19.05Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
19.05Single7B6WCyclazosin7B6W-α1b-Cyclazosin
19.05Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
19.05Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
19.05Single7F1TMIP-1a7F1T-CCR5-MIP-1a
19.05Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.05Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
19.05Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
19.05Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
19.05Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
19.05Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
19.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
19.05Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
19.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
19.05Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
19.05Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
19.05Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
19.05Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
19.05Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
19.05Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
19.05Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
19.05Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
19.05Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.05Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
19.05Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.05Consensustachykinin_offOrthosteric Ligandnk1_off
18.75Single3UZAGTPL92363UZA-A2A-GTPL9236
18.75Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
18.75Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.75Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
18.75Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
18.75Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.75Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.75Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.75Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
18.52Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.52Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
18.18Single3D4STimolol3D4S-β2-Timolol
18.18Single6A93Risperidone6A93-5-HT2A-Risperidone
18.18Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.18Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
18.18Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
18.18Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
18.18Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.18Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
18.18Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.18Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
18.18Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
18.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
18.18Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
18.18Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
18.18Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.18Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
18.18Single8XQJJN2418XQJ-Apelin-JN241
18.18Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.18Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
18.18Single8XYIVUF106618XYI-CXCR3-VUF10661
18.18Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
18.18Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
18.18Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.18Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
18.18Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
18.18Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
18.18Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
18.18Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.86Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.86Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
17.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.86Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.86Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
17.86Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.86Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.86Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.86Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
17.86Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.86Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
17.65Single3PBLEticlopride3PBL-D3-Eticlopride
17.65Single4O9RCyclopamine4O9R-SMO-Cyclopamine
17.65Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
17.65Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single7SRQLSD7SRQ-5-HT2B-LSD
17.65Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
17.65Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.65Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.65Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.65Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.65Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
17.65Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
17.65Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
17.65Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
17.65Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.65Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.65Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
17.65Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
17.65Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
17.65Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.65Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
17.65Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.65Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
17.39Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
17.39Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
17.39Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.39Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
17.39Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
17.39Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
17.39Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.39Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.39Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
17.39Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
17.39Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.39Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XVJMacitentan8XVJ-ETA-Macitentan
17.39Single8XVUCXCL28XVU-CXCR2-CXCL2
17.39Single8XWFCXCL38XWF-CXCR2-CXCL3
17.39Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
17.39Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
17.39Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
17.39Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
17.39Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
17.39Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.39Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.24Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
17.24Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
17.24Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.24Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.24Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.24Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.24Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
17.24Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
17.14Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single4QINSAG1.54QIN-SMO-SAG1.5
16.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
16.67Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
16.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
16.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7F8ULintitript7F8U-CCKA-Lintitript
16.67Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
16.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
16.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
16.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
16.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.67Single7XN9L-054,5227XN9-SST2-L-054,522
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
16.67Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
16.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.67Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
16.67Single8XQJJN2418XQJ-Apelin-JN241
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.67Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
16.67Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
16.67Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
16.67Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
16.67Single9H2XA1IR19H2X-A2A-A1IR1-Na
16.67Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
16.67Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
16.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
16.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
16.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.67Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.67Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.13Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.13Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.13Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.13Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
16.13Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.13Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
16.13Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
16.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
16.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.00Single7F8XNN90567F8X-CCKA-NN9056
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.00Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
16.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
16.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
16.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensussomatostatin_offOrthosteric Ligandsst2_off
16.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.79Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
15.79Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.79Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
15.79Single5UVIZM-2413855UVI-A2A-ZM-241385
15.79Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
15.79Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
15.79Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
15.79Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
15.79Single6TPKRetosiban6TPK-OT-Retosiban
15.79Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
15.79Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
15.79Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.79Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.79Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.79Single6ZINSR486926ZIN-NTS1-SR48692
15.79Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.79Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
15.79Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
15.79Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
15.79Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.79Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
15.79Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
15.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7F61PF-036547467F61-H3-PF-03654746
15.79Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
15.79Single7UL3Famotidine7UL3-H2-Famotidine
15.79Single7VV6C48/807VV6-MRGPRX2-C48/80
15.79Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.79Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.79Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.79Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.79Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
15.79Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.79Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.79Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
15.79Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
15.79Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
15.79Single8K5CAcipimox8K5C-HCA2-Acipimox
15.79Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
15.79Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.79Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
15.79Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
15.79Single8ZPMAMD0708ZPM-CXCR4-AMD070
15.79Single8ZPNAMD31008ZPN-CXCR4-AMD3100
15.79Single9AS3LSD9AS3-5-HT2A-LSD
15.79Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AS5Mescaline9AS5-5-HT2A-Mescaline
15.79Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9BA0A1AKN9BA0-CB1-A1AKN
15.79Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.79Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
15.79Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
15.79Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
15.79Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
15.79Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.79Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.79Consensusgrh_offOrthosteric Ligandgnrh1_off
15.79Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.79Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.79Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensusvasop-oxy_offOrthosteric Ligandot_off
15.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.62Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.38Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
15.38Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Single7SK5CXCL127SK5-ACKR3-CXCL12
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.38Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7XNACYN1548067XNA-SST2-CYN154806
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
15.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.38Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
15.38Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.15Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.15Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
15.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
15.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.00Single4YAYZD-71554YAY-AT1-ZD-7155
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
15.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
15.00Single5T04Neurotensin5T04-NTS1-Neurotensin
15.00Single5TGZAM65385TGZ-CB1-AM6538
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
15.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
15.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.00Single8JJOAlprenolol8JJO-β2-Alprenolol
15.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
15.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
15.00Single8K5DGSK2560738K5D-HCA2-GSK256073
15.00Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
15.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.00Single8X63Mepyramine8X63-H1-Mepyramine
15.00Single8X64Desloratadine8X64-H1-Desloratadine
15.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
15.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
15.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
15.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
15.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
15.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
15.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.00Consensuscck_offOrthosteric Ligandccka_off
15.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
15.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.00Consensushistamine_offOrthosteric Ligandh1_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
14.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
14.81Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
14.81Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
14.81Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.71Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.71Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.71Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.71Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
14.71Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single5MZPCaffeine5MZP-A2A-Caffeine-Na
14.29Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
14.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6PS6Timolol6PS6-β2-Timolol
14.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.29Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
14.29Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
14.29Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7W41PD1762527W41-BB2-PD176252
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.29Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
14.29Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
14.29Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
14.29Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
14.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
14.29Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
14.29Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
14.29Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
14.29Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
14.29Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
14.29Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
14.29Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.29Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
14.29Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
14.29Consensusblt_offOrthosteric Ligandblt1_off
14.29Consensusbombesin_offOrthosteric Ligandbb2_off
14.29Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
14.29Consensusdp_offOrthosteric Liganddp2_off
14.29Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
14.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensustrace-amine_onOrthosteric Ligandta1_on
13.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.89Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.89Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
13.79Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
13.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.79Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
13.79Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.79Consensuspac_onOrthosteric Ligandpac1_on
13.79Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
13.64Single4U15Tiotropium4U15-M3-Tiotropium
13.64Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.64Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.64Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
13.64Single6OL9Tiotropium6OL9-M5-Tiotropium
13.64Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
13.64Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.64Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
13.64Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.64Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
13.64Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.64Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
13.64Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
13.64Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
13.64Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.64Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
13.64Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.64Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.64Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
13.64Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.64Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
13.64Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.64Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
13.64Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.64Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
13.51Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
13.33Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
13.33Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
13.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
13.33Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
13.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
13.33Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single8HS2Fab0468HS2-GPR20-Fab046
13.33Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
13.33Single8PWNTheophylline8PWN-A2A-Theophylline
13.33Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.33Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
13.33Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.33Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
13.16Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4N4WSANT-14N4W-SMO-SANT-1
13.04Single5CXVTiotropium5CXV-M1-Tiotropium
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.04Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.04Single7DFPSpiperone7DFP-D2-Spiperone
13.04Single7K15MKD0467K15-BLT1-MKD046-Na
13.04Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.04Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
13.04Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.04Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
13.04Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
13.04Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
13.04Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.04Single8XWACXCL18XWA-CXCR2-CXCL1
13.04Single8XWMCXCL68XWM-CXCR2-CXCL6
13.04Single8XWSCXCL58XWS-CXCR2-CXCL5
13.04Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.04Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.04Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
13.04Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.90Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.90Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.90Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.90Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.90Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.50Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50Single6TQ9SB-4081246TQ9-OX1-SB-408124
12.50Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.50Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
12.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.50Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.50Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
12.50Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.50Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
12.50Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.50Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.50Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
12.50Single9CHUNoradrenaline9CHU-β2-Noradrenaline
12.50Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
12.50Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuscck_onOrthosteric Ligandccka_on cckb_on
12.50Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
12.50Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.50Consensuschemerin_onOrthosteric Ligandcml1_on
12.50Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.50Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
12.50Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusp2y_offOrthosteric Ligandp2y1_off
12.50Consensusprostanoid_offOrthosteric Ligandep_off dp_off
12.50Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.50Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.12Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
12.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.12Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.12Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.00Single6KNMJN241-96KNM-Apelin-JN241-9
12.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single9JF4PD1683689JF4-BB1-PD168368
12.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.90Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
11.76Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.76Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.76Single3OE6IT1t3OE6-CXCR4-IT1t
11.76Single4XNWMRS25004XNW-P2Y1-MRS2500
11.76Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.76Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.76Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
11.76Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.76Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.76Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
11.76Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.76Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.76Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.76Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.76Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
11.76Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.76Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
11.76Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.76Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.76Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.76Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.76Single9LRCHistamine9LRC-H4-Histamine
11.76Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
11.76Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
11.76Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.76Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.76Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.54Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.54Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.54Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
11.54Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
11.54Single8IEIA1LYA8IEI-GPR156-A1LYA
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.54Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
11.54Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.54Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.54Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.43Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.43Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
11.11Single3OE9IT1t3OE9-CXCR4-IT1t
11.11Single5L7IVismodegib5L7I-SMO-Vismodegib
11.11Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.11Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
11.11Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
11.11Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.11Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.11Single7UL2SR486927UL2-NTS1-SR48692-Na
11.11Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
11.11Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.11Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.11Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.11Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
11.11Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.11Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.11Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
11.11Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.11Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.11Single9B9Y7DY9B9Y-CB1-7DY
11.11Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.11Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
11.11Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
11.11Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
11.11Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
11.11Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
11.11Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.11Consensusneurotensin_offOrthosteric Ligandnts1_off
11.11Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.71Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
10.71Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.71Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
10.71Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.53Single5U09Taranabant5U09-CB1-Taranabant
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.53Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.53Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.53Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.53Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.53Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.53Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.53Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.53Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.53Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.53Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.53Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.53Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.53Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.53Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
10.53Single8IWESpermidine8IWE-TA9-Spermidine
10.53Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
10.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.53Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.53Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
10.53Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.53Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
10.53Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
10.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.53Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
10.53Consensusangiotensin_offOrthosteric Ligandat1_off
10.53Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.53Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.53Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.53Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.53Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.53Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.53Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.53Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.53Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.53Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.53Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.34Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
10.34Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.34Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.34Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
10.34Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
10.00Single2YDOAdenosine2YDO-A2A-Adenosine
10.00Single3RZECidoxepin3RZE-H1-Cidoxepin
10.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.00Single6A94Zotepine6A94-5-HT2A-Zotepine
10.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
10.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
10.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
10.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
10.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
10.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
10.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
10.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
10.00Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
10.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.00Consensuscalcitonin_onOrthosteric Ligandctlike_on
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensushca_onOrthosteric Ligandhca2_on
10.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
10.00Consensussensory_offOrthosteric Ligandopsins_off
9.68Single6FJ3PTH6FJ3-PTH1-PTH
9.68Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
9.68Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.68Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
9.68Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
9.68Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
9.68Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.68Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
9.52Single4DAJTiotropium4DAJ-M3-Tiotropium
9.52Single4MQSIperoxo4MQS-M2-Iperoxo
9.52Single4U14Tiotropium4U14-M3-Tiotropium
9.52Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.52Single5DSGTiotropium5DSG-M4-Tiotropium
9.52Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.52Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.52Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.52Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.52Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
9.52Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.52Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.52Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.52Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
9.52Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.52Single8T1WCVN4248T1W-GPR6-CVN424
9.52Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.52Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.52Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
9.52Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
9.52Single9AS1DMT9AS1-5-HT2A-DMT
9.52Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.52Single9JEAAtropine9JEA-M1-Atropine
9.52Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
9.52Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.52Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.52Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.52Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.52Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.52Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
9.38Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.38Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
9.38Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.38Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.38Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.38Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
9.09Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
9.09Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.09Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.09Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.09Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
9.09Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.09Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.09Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
9.09Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.09Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.09Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.09Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
9.09Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
9.09Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.09Single9HC04YI9HC0-mGlu5-4YI
9.09Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.09Consensusep_offOrthosteric Ligandep4_off
9.09Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.09Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
8.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
8.70Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.70Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
8.70Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.70Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8EA0Iperoxo8EA0-M3-Iperoxo
8.70Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.70Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.70Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.70Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.57Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single6D35Cholesterol6D35-SMO-Cholesterol
8.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
8.33Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
8.33Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
8.33Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
8.33Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
8.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
8.33Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
8.33Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
8.33Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
8.33Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
8.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
8.33Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
8.33Single7DTTCa7DTT-CaS-Ca-Ca
8.33Single7DTTCa7DTT-CaS-Ca-Ca
8.33Single7DTUTryptophan7DTU-CaS-Tryptophan
8.33Single7DTUTryptophan7DTU-CaS-Tryptophan
8.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
8.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
8.33Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
8.33Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
8.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
8.33Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
8.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
8.33Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
8.33Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
8.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
8.33Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
8.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
8.33Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
8.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
8.33Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
8.33Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
8.33Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
8.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
8.33Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
8.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.33Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
8.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
8.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
8.33Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
8.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
8.33Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
8.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
8.33Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
8.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
8.33Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
8.33Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.33Single7XW7K1-707XW7-TSH-K1-70
8.33Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
8.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
8.33Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
8.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
8.33Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
8.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
8.33Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
8.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
8.33Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
8.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
8.33Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
8.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
8.33Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
8.33Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
8.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
8.33Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
8.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
8.33Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
8.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
8.33Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
8.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
8.33Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
8.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.33Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
8.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
8.33Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
8.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
8.33Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
8.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
8.33Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
8.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.33Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
8.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
8.33Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
8.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
8.33Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
8.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
8.33Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
8.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
8.33Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
8.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
8.33Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
8.33Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
8.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
8.33Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
8.33Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
8.33Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
8.33Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
8.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8WVXNorrin8WVX-LGR4-Norrin
8.33Single8WVYNorrin8WVY-LGR4-Norrin
8.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
8.33Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
8.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
8.33Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
8.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
8.33Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
8.33Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
8.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
8.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
8.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
8.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
8.33Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
8.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
8.33Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
8.33Single9KHHNorrin9KHH-LGR4-Norrin
8.33Single9S37NB219S37-LGR4-NB21
8.33Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
8.33Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.33Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
8.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.69Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.69Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.69Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
7.69Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.69Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
7.69Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
7.69Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
7.69Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
7.69Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.69Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
7.41Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
7.32Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.14Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.14Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
7.14Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
7.14Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.14Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
6.67Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
6.67Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
6.67Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
6.67Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
6.67Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
6.67Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.67Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
6.25Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
6.25Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
6.25Single5L7DCholesterol5L7D-SMO-Cholesterol
6.25Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
6.25Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
6.25Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.25Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.88Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.88Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.88Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.88Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
5.88Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
5.88Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
5.88Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
5.88Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
5.88Consensussensory_onOrthosteric Ligandopsins_on
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.56Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.56Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.56Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Single8JPSCCL78JPS-ACKR1-CCL7
5.56Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.56Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.56Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
5.56Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
5.26Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.26Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
5.26Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.26Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.26Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.26Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
5.26Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.26Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
5.26Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
5.26Single8K5BNiacin8K5B-HCA2-Niacin
5.26Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.26Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
5.26Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9AS7Psilocin9AS7-5-HT2A-Psilocin
5.26Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
5.26Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.26Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.00Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
4.76Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
4.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
4.76Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
4.55Single6IIVDaltroban6IIV-TXA2-Daltroban
4.55Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.35Single5CGCHTL142425CGC-mGlu5-HTL14242
4.35Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
4.35Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.35Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.35Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.17Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
4.17Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.17Single9AS9RS130-1809AS9-5-HT2A-RS130-180
4.17Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single6IIURamatroban6IIU-TXA2-Ramatroban
4.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
4.00Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single5CGDHTL142425CGD-mGlu5-HTL14242
3.85Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.85Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
3.85Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
3.85Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.57Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.57Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.33Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.33Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.23Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.23Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.94Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
7TD1 7TD1-LPA1-LPA-Gi1/β1/γ2
7YU3 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
Net Summary
Imin 2.875
Number of Linked Nodes 893
Number of Links 1080
Number of Hubs 161
Number of Links mediated by Hubs 621
Number of Communities 33
Number of Nodes involved in Communities 224
Number of Links involved in Communities 309
Path Summary
Number Of Nodes in MetaPath 131
Number Of Links MetaPath 130
Number of Shortest Paths 989486
Length Of Smallest Path 3
Average Path Length 34.6264
Length of Longest Path 76
Minimum Path Strength 0.655
Average Path Strength 5.98566
Maximum Path Strength 25.34
Minimum Path Correlation 0.7
Average Path Correlation 0.980236
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 46.1248
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.2567
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
lpa1_off_on_gplpa1_on_gplpa1_off
This network is also present in following consensuses:
IdComponents
lpa_on_gplpa1_on_gp



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