Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I306 R:R:V50 4.61 2 Yes No 7 7 1 2
R:R:F88 R:R:N89 3.62 2 Yes Yes 8 6 1 2
R:R:F88 R:R:L92 2.44 2 Yes Yes 8 8 1 1
R:R:F88 R:R:L119 7.31 2 Yes No 8 6 1 1
R:R:F88 R:R:N122 6.04 2 Yes Yes 8 8 1 2
R:R:F88 R:R:I306 3.77 2 Yes Yes 8 7 1 1
R:R:F88 R:R:S309 2.64 2 Yes No 8 9 1 2
L:L:F156 R:R:F88 2.14 2 Yes Yes 0 8 0 1
R:R:N89 R:R:S309 5.96 2 Yes No 6 9 2 2
R:R:L92 R:R:P93 3.28 2 Yes No 8 8 1 2
R:R:I96 R:R:L92 4.28 2 Yes Yes 7 8 2 1
R:R:I306 R:R:L92 4.28 2 Yes Yes 7 8 1 1
L:L:F156 R:R:L92 2.44 2 Yes Yes 0 8 0 1
R:R:I96 R:R:P93 3.39 2 Yes No 7 8 2 2
R:R:H95 R:R:Y98 6.53 0 No No 6 5 1 2
L:L:F156 R:R:H95 9.05 2 Yes No 0 6 0 1
R:R:Y103 R:R:Y98 11.91 0 Yes No 4 5 1 2
R:R:A99 R:R:Y103 5.34 0 No Yes 5 4 2 1
R:R:D102 R:R:Y103 3.45 0 No Yes 4 4 2 1
R:R:P299 R:R:Y103 2.78 0 No Yes 3 4 2 1
L:L:F154 R:R:Y103 12.38 18 Yes Yes 0 4 0 1
L:L:F156 R:R:L119 2.44 2 Yes No 0 6 0 1
R:R:I120 R:R:M123 2.92 2 Yes Yes 4 8 2 1
R:R:F124 R:R:I120 2.51 2 Yes Yes 7 4 2 2
R:R:I120 R:R:R224 6.26 2 Yes Yes 4 5 2 1
R:R:F124 R:R:M123 6.22 2 Yes Yes 7 8 2 1
R:R:M123 R:R:W273 4.65 2 Yes Yes 8 9 1 2
L:L:F156 R:R:M123 2.49 2 Yes Yes 0 8 0 1
R:R:F124 R:R:R224 4.28 2 Yes Yes 7 5 2 1
R:R:F124 R:R:H277 2.26 2 Yes Yes 7 8 2 2
R:R:P173 R:R:R224 2.88 0 No Yes 8 5 2 1
R:R:N191 R:R:R178 8.44 2 Yes Yes 5 5 1 2
R:R:A181 R:R:F190 2.77 0 No Yes 2 3 2 1
R:R:F190 R:R:S188 3.96 0 Yes No 3 4 1 2
R:R:F190 R:R:N192 6.04 0 Yes No 3 2 1 2
L:L:F150 R:R:F190 18.22 0 No Yes 0 3 0 1
R:R:F193 R:R:N191 3.62 0 Yes Yes 5 5 2 1
L:L:G152 R:R:N191 3.39 2 No Yes 0 5 0 1
L:L:S157 R:R:N191 8.94 2 No Yes 0 5 0 1
R:R:F193 R:R:H217 18.1 0 Yes Yes 5 4 2 1
R:R:F193 R:R:V220 2.62 0 Yes No 5 5 2 2
R:R:H217 R:R:T221 6.85 10 Yes No 4 6 1 2
R:R:E283 R:R:H217 7.39 10 No Yes 4 4 1 1
R:R:H217 R:R:L284 7.71 10 Yes No 4 5 1 2
L:L:P151 R:R:H217 7.63 10 No Yes 0 4 0 1
R:R:R224 R:R:V220 2.62 2 Yes No 5 5 1 2
L:L:S157 R:R:R224 3.95 2 No Yes 0 5 0 1
R:R:H277 R:R:W273 6.35 2 Yes Yes 8 9 2 2
R:R:H277 R:R:Y276 2.18 2 Yes Yes 8 6 2 1
R:R:N280 R:R:Y276 10.47 0 No Yes 5 6 2 1
L:L:A155 R:R:Y276 2.67 0 No Yes 0 6 0 1
L:L:F156 R:R:Y276 6.19 2 Yes Yes 0 6 0 1
R:R:L279 R:R:L298 4.15 0 No No 4 4 2 1
R:R:F294 R:R:L282 3.65 0 Yes No 5 5 1 2
R:R:E283 R:R:F294 3.5 10 No Yes 4 5 1 1
L:L:P151 R:R:E283 4.72 10 No No 0 4 0 1
R:R:H286 R:R:T287 4.11 0 No No 2 1 1 2
R:R:F294 R:R:H286 2.26 0 Yes No 5 2 1 1
L:L:P151 R:R:H286 7.63 10 No No 0 2 0 1
R:R:F294 R:R:V293 2.62 0 Yes No 5 1 1 2
R:R:F294 R:R:L298 2.44 0 Yes No 5 4 1 1
L:L:Y149 R:R:F294 7.22 18 No Yes 0 5 0 1
L:L:F154 R:R:S295 5.28 18 Yes No 0 4 0 1
L:L:A155 R:R:L298 3.15 0 No No 0 4 0 1
L:L:F156 R:R:T302 3.89 2 Yes No 0 6 0 1
L:L:F156 R:R:I306 2.51 2 Yes Yes 0 7 0 1
R:R:F294 R:R:G291 1.51 0 Yes No 5 2 1 2
R:R:A305 R:R:Y276 1.33 0 No Yes 8 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8SG1
Class A
SubFamily Protein
Type Chemerin
SubType CML1
Species Homo Sapiens
Ligand Chemerin-9
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.94
Date 2023-11-01
D.O.I. 10.1371/journal.pbio.3002188
Net Summary
Imin 1.82
Number of Linked Nodes 848
Number of Links 1177
Number of Hubs 218
Number of Links mediated by Hubs 814
Number of Communities 19
Number of Nodes involved in Communities 329
Number of Links involved in Communities 544
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 5506311
Length Of Smallest Path 3
Average Path Length 32.9647
Length of Longest Path 53
Minimum Path Strength 1.155
Average Path Strength 4.49232
Maximum Path Strength 20.02
Minimum Path Correlation 0.7
Average Path Correlation 0.992993
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 33.7994
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.5244
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ99788
Sequence
>8SG1_Chain_R
ARVTRIFLV VVYSIVCFL GILGNGLVI IIATFKMKK TVNMVWFLN 
LAVADFLFN VFLPIHITY AAMDYHWVF GTAMCKISN FLLIHNMFT 
SVFLLTIIS SDRCISVLL PVWSQNHRS VRLAYMACM VIWVLAFFL 
SSPSLVFRD TANLHGKIS CFNNFSLSD PVGYSRHMV VTVTRFLCG 
FLVPVLIIT ACYLTIVCK LQRNRLAKT KKPFKIIVT IIITFFLCW 
CPYHTLNLL ELHHTAMPG SVFSLGLPL ATALAIANS CMNPILYVF 
MGQDFKKFK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8SG1_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8SG1_Chain_G
IAQARKLVQ QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASQNPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8SG1_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVNRMH ASMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STTKNVQFV FDAVTDVII KNNLKDCGL F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
cml1_on8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
gi_chemerin8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YKDAProteinChemerinCML1Homo sapiensChemerin-9-Gi1/&β;1/&γ;22.812023-04-1910.1073/pnas.2214324120
8SG1AProteinChemerinCML1Homo sapiensChemerin-9-Gi1/&β;1/&γ;22.942023-11-0110.1371/journal.pbio.3002188




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8SG1.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.