psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L22	L:L:V66	2.98	No	No	0	0	0
2	L:L:R27	L:L:T23	9.06	No	No	0	0	0
3	L:L:L68	L:L:T23	2.95	Yes	No	0	0	0
4	L:L:Q26	L:L:V66	12.89	No	No	6	0	0
5	L:L:L68	L:L:Q26	18.63	Yes	No	6	0	0
6	L:L:I102	L:L:Q26	17.84	No	No	0	0	0
7	L:L:E49	L:L:R27	20.93	No	No	0	0	0
8	L:L:R27	L:L:V52	2.62	No	No	0	0	0
9	L:L:L30	L:L:L34	4.15	No	Yes	0	0	0
10	L:L:F70	L:L:L30	9.74	No	No	0	0	0
11	L:L:L34	L:L:Q31	3.99	Yes	No	5	0	0
12	L:L:Q31	L:L:Q48	6.4	No	No	5	0	0
13	L:L:Q31	L:L:W82	29.57	No	Yes	5	0	0
14	L:L:A33	L:L:R113	4.15	No	No	0	0	0
15	L:L:F47	L:L:L34	6.09	No	Yes	0	0	0
16	L:L:L34	L:L:W82	11.39	Yes	Yes	5	0	0
17	L:L:E35	L:L:K79	4.05	No	No	0	0	0
18	L:L:E35	L:L:W82	29.44	No	Yes	0	0	0
19	L:L:E36	L:L:F37	17.49	No	No	0	0	0
20	L:L:Q74	L:L:W45	3.29	No	No	0	0	0
21	L:L:R78	L:L:W45	18.99	No	No	0	0	0
22	L:L:A46	L:L:K79	3.21	No	No	0	0	0
23	L:L:A46	L:L:W82	5.19	No	Yes	0	0	0
24	L:L:F47	L:L:Q74	11.71	No	No	0	0	0
25	L:L:F47	L:L:R96	3.21	No	Yes	0	0	0
26	L:L:Q48	L:L:T75	7.09	No	No	5	0	0
27	L:L:C77	L:L:Q48	4.58	Yes	No	5	0	0
28	L:L:E49	L:L:F70	7	No	No	0	0	0
29	L:L:E53	L:L:S54	4.31	No	No	0	0	0
30	L:L:E53	L:L:K71	4.05	No	No	7	0	0
31	L:L:E53	L:L:K97	5.4	No	No	7	0	0
32	L:L:E69	L:L:S54	8.62	No	No	0	0	0
33	L:L:I64	L:L:K103	4.36	No	Yes	0	0	0
34	L:L:C101	L:L:F65	4.19	No	Yes	0	0	0
35	L:L:F65	L:L:K103	13.65	Yes	Yes	0	0	0
36	L:L:F65	L:L:V138	3.93	Yes	No	0	0	0
37	L:L:F65	L:L:Q139	3.51	Yes	No	0	0	0
38	L:L:L68	L:L:V66	2.98	Yes	No	6	0	0
39	L:L:E69	L:L:R67	9.3	No	No	0	0	0
40	L:L:Q139	L:L:R67	11.68	No	No	0	0	0
41	L:L:F70	L:L:L68	10.96	No	Yes	0	0	0
42	L:L:E69	L:L:L99	22.53	No	No	0	0	0
43	L:L:K71	L:L:K97	5.75	No	No	7	0	0
44	L:L:L72	L:L:R96	14.58	No	Yes	0	0	0
45	L:L:G93	L:L:Q73	4.93	No	No	0	0	0
46	L:L:C77	L:L:T75	3.38	Yes	No	5	0	0
47	L:L:T75	L:L:V89	3.17	No	No	0	0	0
48	L:L:K88	L:L:S76	4.59	No	No	0	0	0
49	L:L:C77	L:L:C87	7.28	Yes	No	0	0	0
50	L:L:R78	L:L:R80	6.4	No	No	0	0	0
51	L:L:D81	L:L:K84	5.53	No	No	0	0	0
52	L:L:R94	L:L:R96	3.2	No	Yes	0	0	0
53	L:L:K95	L:L:K97	17.24	No	No	0	0	0
54	L:L:C98	L:L:R96	15.32	No	Yes	0	0	0
55	L:L:C117	L:L:C98	7.28	No	No	0	0	0
56	L:L:L114	L:L:L99	5.54	Yes	No	0	0	0
57	L:L:E132	L:L:L99	3.98	No	No	0	0	0
58	L:L:C101	L:L:L114	3.17	No	Yes	8	0	0
59	L:L:C101	L:L:C135	7.28	No	No	8	0	0
60	L:L:I102	L:L:L104	2.85	No	No	0	0	0
61	L:L:K103	L:L:K109	2.87	Yes	No	0	0	0
62	L:L:G105	L:L:K109	3.49	No	No	0	0	0
63	L:L:K109	L:L:L111	2.82	No	No	0	0	0
64	L:L:G112	L:L:V138	5.52	No	No	0	0	0
65	L:L:H116	L:L:L114	10.29	No	Yes	0	0	0
66	L:L:L114	L:L:Q134	2.66	Yes	No	0	0	0
67	L:L:C135	L:L:L114	6.35	No	Yes	8	0	0
68	L:L:Q131	L:L:T133	2.83	No	No	0	0	0
69	L:L:L136	L:L:Q139	3.99	No	No	0	0	0
70	L:L:R137	L:L:V138	2.62	No	No	0	0	0
71	L:L:E143	L:L:S147	7.19	No	No	0	0	0
72	L:L:D144	L:L:P145	8.05	No	No	0	0	0
73	L:L:D144	L:L:H146	3.78	No	No	0	0	0
74	L:L:H146	L:L:Y149	3.27	No	Yes	0	0	0
75	L:L:H146	R:R:G291	9.53	No	No	0	0	2
76	L:L:F148	L:L:S147	6.61	No	No	0	0	0
77	L:L:F148	R:R:L183	4.87	No	No	0	0	1
78	L:L:Q153	L:L:Y149	5.64	No	Yes	1	0	0
79	L:L:F154	L:L:Y149	7.22	Yes	Yes	1	0	0
80	L:L:Y149	R:R:E283	5.61	Yes	Yes	1	0	4
81	L:L:Y149	R:R:F294	3.09	Yes	Yes	1	0	5
82	L:L:F150	L:L:Q153	8.2	Yes	No	1	0	0
83	L:L:F150	R:R:A181	2.77	Yes	No	1	0	2
84	L:L:F150	R:R:L183	10.96	Yes	No	0	0	1
85	L:L:F150	R:R:F190	11.79	Yes	No	1	0	3
86	L:L:P151	R:R:E283	3.14	No	Yes	0	0	4
87	L:L:G152	R:R:N191	3.39	No	No	0	0	5
88	L:L:F154	L:L:Q153	7.03	Yes	No	1	0	0
89	L:L:F154	R:R:Y103	10.32	Yes	Yes	0	0	4
90	L:L:F154	R:R:S295	7.93	Yes	No	0	0	4
91	L:L:F156	R:R:M123	7.46	No	Yes	0	0	8
92	L:L:F156	R:R:Y276	24.76	No	No	0	0	6
93	L:L:F156	R:R:T302	7.78	No	No	0	0	6
94	L:L:S157	R:R:R178	2.64	Yes	Yes	2	0	5
95	L:L:S157	R:R:N191	7.45	Yes	No	2	0	5
96	L:L:S157	R:R:R224	6.59	Yes	Yes	0	0	5
97	L:L:S157	R:R:N280	2.98	Yes	No	0	0	5
98	R:R:E35	R:R:V38	7.13	No	No	0	3	4
99	R:R:R37	R:R:R40	11.73	No	No	0	3	4
100	R:R:D102	R:R:R40	4.76	No	No	0	4	4
101	R:R:R40	R:R:Y103	4.12	No	Yes	0	4	4
102	R:R:L43	R:R:V46	2.98	No	No	0	6	5
103	R:R:L43	R:R:Y47	11.72	No	No	0	6	8
104	R:R:I49	R:R:V45	3.07	No	No	0	4	5
105	R:R:T302	R:R:Y47	8.74	No	No	0	6	8
106	R:R:A303	R:R:Y47	2.67	No	No	0	5	8
107	R:R:F52	R:R:I49	3.77	No	No	0	5	4
108	R:R:I306	R:R:V50	3.07	No	No	0	7	7
109	R:R:C51	R:R:L92	6.35	No	No	9	6	8
110	R:R:C51	R:R:P93	5.65	No	No	0	6	8
111	R:R:C51	R:R:I96	3.27	No	No	9	6	7
112	R:R:G54	R:R:N89	3.39	No	Yes	0	8	6
113	R:R:C310	R:R:G54	3.92	No	No	0	8	8
114	R:R:I55	R:R:N89	5.66	No	Yes	0	5	6
115	R:R:D85	R:R:N58	13.46	No	No	10	9	9
116	R:R:N58	R:R:N89	4.09	No	Yes	10	9	6
117	R:R:V317	R:R:V61	4.81	No	No	0	7	9
118	R:R:A82	R:R:I62	3.25	No	No	0	8	7
119	R:R:I64	R:R:K68	4.36	No	No	11	7	4
120	R:R:F326	R:R:I64	11.3	No	No	11	4	7
121	R:R:F67	R:R:T66	7.78	No	No	0	5	4
122	R:R:L79	R:R:T66	4.42	No	No	0	5	4
123	R:R:F326	R:R:K68	3.72	No	No	11	4	4
124	R:R:M69	R:R:M75	2.89	No	Yes	0	5	8
125	R:R:D322	R:R:M69	5.54	Yes	No	0	6	5
126	R:R:K71	R:R:M75	5.76	No	Yes	0	6	8
127	R:R:V73	R:R:W77	6.13	No	Yes	0	6	7
128	R:R:R151	R:R:V73	9.15	Yes	No	0	6	6
129	R:R:F78	R:R:N74	3.62	No	No	0	8	8
130	R:R:N74	R:R:R151	3.62	No	Yes	0	8	6
131	R:R:L79	R:R:M75	2.83	No	Yes	0	5	8
132	R:R:N80	R:R:V76	4.43	No	No	0	9	6
133	R:R:A156	R:R:V76	5.09	No	No	0	7	6
134	R:R:V76	R:R:Y157	8.83	No	No	0	6	3
135	R:R:I132	R:R:W77	9.4	No	Yes	0	6	7
136	R:R:I133	R:R:W77	7.05	No	Yes	0	9	7
137	R:R:D136	R:R:W77	5.58	No	Yes	0	8	7
138	R:R:C160	R:R:W77	3.92	No	Yes	0	7	7
139	R:R:F78	R:R:V317	7.87	No	No	0	8	7
140	R:R:C160	R:R:N80	6.3	No	No	0	7	9
141	R:R:L130	R:R:L81	2.77	No	No	0	8	9
142	R:R:A84	R:R:T125	3.36	No	No	0	8	7
143	R:R:D85	R:R:N89	8.08	No	Yes	10	9	6
144	R:R:D85	R:R:S309	8.83	No	No	0	9	9
145	R:R:F91	R:R:L87	6.09	No	Yes	0	6	7
146	R:R:L87	R:R:N122	5.49	Yes	No	0	7	8
147	R:R:F88	R:R:N89	4.83	Yes	Yes	0	8	6
148	R:R:F88	R:R:L119	8.53	Yes	No	0	8	6
149	R:R:F88	R:R:N122	6.04	Yes	No	0	8	8
150	R:R:F88	R:R:M123	6.22	Yes	Yes	0	8	8
151	R:R:F88	R:R:I306	5.02	Yes	No	0	8	7
152	R:R:F88	R:R:S309	7.93	Yes	No	0	8	9
153	R:R:F91	R:R:L118	9.74	No	No	0	6	5
154	R:R:I96	R:R:L92	8.56	No	No	9	7	8
155	R:R:I306	R:R:L92	5.71	No	No	0	7	8
156	R:R:I94	R:R:W105	7.05	Yes	Yes	2	6	9
157	R:R:F107	R:R:I94	3.77	No	Yes	0	8	6
158	R:R:I94	R:R:M111	4.37	Yes	No	2	6	6
159	R:R:I94	R:R:S115	9.29	Yes	No	0	6	5
160	R:R:H95	R:R:Y98	5.44	No	Yes	0	6	5
161	R:R:F107	R:R:T97	6.49	No	No	0	8	4
162	R:R:Y103	R:R:Y98	8.94	Yes	Yes	0	4	5
163	R:R:W105	R:R:Y98	10.61	Yes	Yes	0	9	5
164	R:R:S188	R:R:Y98	5.09	No	Yes	0	4	5
165	R:R:A99	R:R:Y103	2.67	No	Yes	0	5	4
166	R:R:P299	R:R:Y103	4.17	No	Yes	0	3	4
167	R:R:H104	R:R:V106	12.45	No	No	0	5	3
168	R:R:H104	R:R:K186	3.93	No	No	0	5	2
169	R:R:H104	R:R:I187	3.98	No	No	0	5	5
170	R:R:M111	R:R:W105	5.82	No	Yes	2	6	9
171	R:R:C112	R:R:W105	9.14	Yes	Yes	2	9	9
172	R:R:F107	R:R:V106	2.62	No	No	0	8	3
173	R:R:T109	R:R:T180	3.14	No	No	0	3	4
174	R:R:A110	R:R:K113	3.21	No	No	0	3	7
175	R:R:C112	R:R:N116	4.72	Yes	No	2	9	6
176	R:R:C112	R:R:R178	9.75	Yes	Yes	2	9	5
177	R:R:C112	R:R:C189	7.28	Yes	No	2	9	9
178	R:R:K113	R:R:R178	3.71	No	Yes	0	7	5
179	R:R:I114	R:R:L118	4.28	No	No	0	4	5
180	R:R:N116	R:R:R178	12.05	No	Yes	2	6	5
181	R:R:F117	R:R:L118	4.87	Yes	No	0	5	5
182	R:R:F117	R:R:F168	5.36	Yes	No	0	5	3
183	R:R:F117	R:R:S171	2.64	Yes	No	0	5	7
184	R:R:F117	R:R:S174	3.96	Yes	No	0	5	5
185	R:R:F117	R:R:L175	6.09	Yes	No	0	5	4
186	R:R:I120	R:R:M123	4.37	No	Yes	0	4	8
187	R:R:I120	R:R:S171	4.64	No	No	0	4	7
188	R:R:I120	R:R:R224	6.26	No	Yes	0	4	5
189	R:R:H121	R:R:T125	4.11	Yes	No	13	5	7
190	R:R:H121	R:R:W164	6.35	Yes	No	13	5	9
191	R:R:A167	R:R:H121	7.32	No	Yes	0	8	5
192	R:R:F168	R:R:H121	5.66	No	Yes	0	3	5
193	R:R:H121	R:R:S171	6.97	Yes	No	0	5	7
194	R:R:F124	R:R:M123	4.98	Yes	Yes	0	7	8
195	R:R:F124	R:R:L170	4.87	Yes	No	0	7	5
196	R:R:F124	R:R:R224	3.21	Yes	Yes	0	7	5
197	R:R:F124	R:R:G228	3.01	Yes	No	0	7	6
198	R:R:T125	R:R:W164	14.55	No	No	13	7	9
199	R:R:P232	R:R:V127	3.53	Yes	Yes	3	9	7
200	R:R:F269	R:R:V127	2.62	Yes	Yes	3	9	7
201	R:R:V127	R:R:W273	3.68	Yes	Yes	3	7	9
202	R:R:F128	R:R:I163	6.28	No	No	0	6	7
203	R:R:A167	R:R:F128	2.77	No	No	0	8	6
204	R:R:I163	R:R:L129	2.85	No	No	0	7	8
205	R:R:L130	R:R:N312	9.61	No	No	4	8	9
206	R:R:L130	R:R:Y316	11.72	No	Yes	4	8	9
207	R:R:P232	R:R:T131	3.5	Yes	No	0	9	7
208	R:R:I235	R:R:T131	4.56	No	No	0	7	7
209	R:R:I236	R:R:T131	3.04	No	No	0	8	7
210	R:R:I132	R:R:I163	2.94	No	No	0	6	7
211	R:R:I133	R:R:R137	6.26	No	No	0	9	9
212	R:R:I236	R:R:S134	7.74	No	No	0	8	9
213	R:R:C239	R:R:S134	5.16	No	No	0	7	9
214	R:R:S134	R:R:Y240	12.72	No	Yes	0	9	9
215	R:R:D136	R:R:R151	9.53	No	Yes	0	8	6
216	R:R:R137	R:R:Y240	4.12	No	Yes	4	9	9
217	R:R:R137	R:R:Y316	6.17	No	Yes	4	9	9
218	R:R:C138	R:R:L142	3.17	No	No	14	8	7
219	R:R:C138	R:R:C239	7.28	No	No	0	8	7
220	R:R:C138	R:R:T242	5.07	No	No	14	8	4
221	R:R:I139	R:R:L143	2.85	No	No	0	5	6
222	R:R:S140	R:R:S147	6.52	No	No	12	7	4
223	R:R:R151	R:R:S140	2.64	Yes	No	12	6	7
224	R:R:L142	R:R:V141	2.98	No	No	0	7	8
225	R:R:I243	R:R:V141	6.14	No	No	0	8	8
226	R:R:K246	R:R:V141	3.04	No	No	0	5	8
227	R:R:L142	R:R:T242	4.42	No	No	14	7	4
228	R:R:H150	R:R:W146	21.16	No	No	0	4	4
229	R:R:R151	R:R:S147	7.91	Yes	No	12	6	4
230	R:R:H150	R:R:N149	3.83	No	No	0	4	4
231	R:R:L155	R:R:S152	4.5	No	No	0	3	6
232	R:R:F169	R:R:V165	2.62	No	No	0	3	4
233	R:R:L170	R:R:T223	2.95	No	No	0	5	4
234	R:R:P173	R:R:S172	3.56	No	No	0	8	4
235	R:R:F177	R:R:P173	2.89	Yes	No	0	4	8
236	R:R:P173	R:R:V220	3.53	No	No	0	8	5
237	R:R:F177	R:R:V176	7.87	Yes	No	0	4	4
238	R:R:F177	R:R:S215	5.28	Yes	No	0	4	1
239	R:R:C189	R:R:R178	5.57	No	Yes	2	9	5
240	R:R:N191	R:R:R178	8.44	No	Yes	2	5	5
241	R:R:C189	R:R:T180	5.07	No	No	0	9	4
242	R:R:A181	R:R:F190	2.77	No	No	1	2	3
243	R:R:A181	R:R:L195	4.73	No	No	0	2	4
244	R:R:G185	R:R:N182	5.09	No	No	0	6	1
245	R:R:I187	R:R:N182	4.25	No	No	0	5	1
246	R:R:F193	R:R:S194	7.93	No	No	0	5	3
247	R:R:F193	R:R:Y214	16.5	No	No	0	5	1
248	R:R:S215	R:R:V220	6.46	No	No	0	1	5
249	R:R:H217	R:R:T221	8.21	No	No	1	4	6
250	R:R:H217	R:R:L284	10.29	No	No	1	4	5
251	R:R:R224	R:R:V220	6.54	Yes	No	0	5	5
252	R:R:L284	R:R:T221	4.42	No	No	1	5	6
253	R:R:L226	R:R:V222	2.98	No	No	0	4	4
254	R:R:F225	R:R:F229	7.5	Yes	Yes	3	5	9
255	R:R:F225	R:R:H277	4.53	Yes	No	3	5	8
256	R:R:F225	R:R:L281	3.65	Yes	No	0	5	5
257	R:R:L226	R:R:L230	2.77	No	No	0	4	4
258	R:R:F229	R:R:F270	3.22	Yes	No	3	9	6
259	R:R:C274	R:R:F229	2.79	No	Yes	3	6	9
260	R:R:F229	R:R:H277	10.18	Yes	No	3	9	8
261	R:R:P232	R:R:V231	3.53	Yes	No	0	9	6
262	R:R:I235	R:R:V231	3.07	No	No	0	7	6
263	R:R:F269	R:R:P232	2.89	Yes	Yes	3	9	9
264	R:R:F269	R:R:V233	5.24	Yes	No	0	9	5
265	R:R:F269	R:R:I236	3.77	Yes	No	0	9	8
266	R:R:L241	R:R:T237	2.95	No	No	0	3	4
267	R:R:I262	R:R:Y240	18.13	No	Yes	4	8	9
268	R:R:I265	R:R:Y240	9.67	Yes	Yes	4	8	9
269	R:R:I266	R:R:Y240	3.63	No	Yes	4	8	9
270	R:R:Y240	R:R:Y316	2.98	Yes	Yes	4	9	9
271	R:R:I243	R:R:L247	2.85	No	Yes	0	8	8
272	R:R:F259	R:R:V244	3.93	No	No	0	7	5
273	R:R:I262	R:R:V244	3.07	No	No	0	8	5
274	R:R:K246	R:R:R249	7.43	No	No	0	5	5
275	R:R:L247	R:R:L252	4.15	Yes	No	0	8	3
276	R:R:L247	R:R:P258	3.28	Yes	No	0	8	7
277	R:R:L252	R:R:N250	13.73	No	No	0	3	5
278	R:R:K256	R:R:K260	2.87	No	No	0	5	5
279	R:R:K257	R:R:P258	3.35	No	No	0	7	7
280	R:R:I261	R:R:K257	4.36	No	No	0	8	7
281	R:R:I261	R:R:I265	2.94	No	Yes	0	8	8
282	R:R:I261	R:R:M319	5.83	No	No	0	8	6
283	R:R:I262	R:R:I266	2.94	No	No	4	8	8
284	R:R:L315	R:R:T264	4.42	No	No	0	7	5
285	R:R:I265	R:R:L315	7.14	Yes	No	0	8	7
286	R:R:I265	R:R:Y316	9.67	Yes	Yes	4	8	9
287	R:R:F269	R:R:W273	14.03	Yes	Yes	3	9	9
288	R:R:C274	R:R:F270	9.78	No	No	3	6	6
289	R:R:L271	R:R:L304	2.77	No	No	0	6	7
290	R:R:C272	R:R:N308	7.87	No	No	0	9	9
291	R:R:H277	R:R:W273	8.46	No	Yes	3	8	9
292	R:R:A305	R:R:W273	3.89	No	Yes	0	8	9
293	R:R:N308	R:R:W273	7.91	No	Yes	0	9	9
294	R:R:A301	R:R:Y276	4	No	No	0	7	6
295	R:R:L279	R:R:L298	8.3	No	No	0	4	4
296	R:R:L282	R:R:M289	8.48	No	No	0	5	3
297	R:R:E283	R:R:F294	3.5	Yes	Yes	1	4	5
298	R:R:H286	R:R:T287	6.85	No	No	0	2	1
299	R:R:P290	R:R:S292	3.56	No	No	0	1	4
300	R:R:F294	R:R:V293	3.93	Yes	No	0	5	1
301	R:R:N308	R:R:N312	10.9	No	No	0	9	9
302	R:R:I314	R:R:M311	2.92	No	No	0	6	6
303	R:R:N312	R:R:Y316	5.81	No	Yes	4	9	9
304	R:R:F318	R:R:P313	2.89	No	No	0	6	9
305	R:R:F318	R:R:I314	3.77	No	No	0	6	6
306	R:R:F318	R:R:F323	18.22	No	No	0	6	8
307	R:R:D322	R:R:Q321	3.92	Yes	No	0	6	5
308	R:R:F326	R:R:L330	13.4	No	No	0	4	4
309	R:R:R37	R:R:T39	2.59	No	No	0	3	4
310	R:R:A159	R:R:W77	2.59	No	Yes	0	5	7
311	R:R:F86	R:R:I62	2.51	No	No	0	8	7
312	R:R:F323	R:R:K327	2.48	No	No	0	8	6
313	R:R:E283	R:R:H217	2.46	Yes	No	1	4	4
314	L:L:F154	R:R:L298	2.44	Yes	No	0	0	4
315	R:R:F86	R:R:L87	2.44	No	Yes	0	8	7
316	R:R:F225	R:R:L226	2.44	Yes	No	0	5	4
317	R:R:F294	R:R:L282	2.44	Yes	No	0	5	5
318	R:R:F294	R:R:L298	2.44	Yes	No	0	5	4
319	R:R:F190	R:R:N192	2.42	No	No	0	3	2
320	R:R:K71	R:R:Y157	2.39	No	No	0	6	3
321	R:R:D322	R:R:F323	2.39	Yes	No	0	6	8
322	R:R:I139	R:R:W146	2.35	No	No	0	5	4
323	R:R:F294	R:R:H286	2.26	Yes	No	0	5	2
324	R:R:G291	R:R:P290	2.03	No	No	0	2	1
325	L:L:A62	L:L:G63	1.95	No	No	0	0	0
326	L:L:A155	L:L:G152	1.95	No	No	0	0	0
327	R:R:C274	R:R:P275	1.88	No	No	0	6	9
328	R:R:G213	R:R:V212	1.84	No	No	0	3	3
329	L:L:P61	L:L:V56	1.77	No	No	0	0	0
330	R:R:P211	R:R:V212	1.77	No	No	0	2	3
331	L:L:G63	L:L:I64	1.76	No	No	0	0	0
332	R:R:G320	R:R:K324	1.74	No	No	0	8	8
333	R:R:C239	R:R:S135	1.72	No	No	0	7	6
334	L:L:G105	L:L:L104	1.71	No	No	0	0	0
335	R:R:G54	R:R:L53	1.71	No	No	0	8	5
336	R:R:G57	R:R:L56	1.71	No	No	0	7	5
337	R:R:G57	R:R:L60	1.71	No	No	0	7	6
338	R:R:G297	R:R:L279	1.71	No	No	0	5	4
339	R:R:G297	R:R:L296	1.71	No	No	0	5	1
340	R:R:G297	R:R:L300	1.71	No	No	0	5	5
341	R:R:A100	R:R:V44	1.7	No	No	0	5	5
342	R:R:C227	R:R:T223	1.69	No	No	0	4	4
343	R:R:C272	R:R:T268	1.69	No	No	0	9	7
344	R:R:D322	R:R:G320	1.68	Yes	No	0	6	8
345	L:L:K84	L:L:P85	1.67	No	No	0	0	0
346	L:L:E143	L:L:G142	1.64	No	No	0	0	0
347	R:R:L143	R:R:P144	1.64	No	No	0	6	8
348	R:R:L304	R:R:P275	1.64	No	No	0	7	9
349	R:R:S126	R:R:V127	1.62	No	Yes	0	9	7
350	R:R:S215	R:R:V219	1.62	No	No	0	1	3
351	R:R:A65	R:R:M69	1.61	No	No	0	6	5
352	L:L:S51	L:L:T50	1.6	No	No	0	0	0
353	R:R:V44	R:R:V45	1.6	No	No	0	5	5
354	R:R:T237	R:R:V233	1.59	No	No	0	4	5
355	L:L:A25	L:L:L104	1.58	No	No	0	0	0
356	L:L:A55	L:L:L68	1.58	No	Yes	0	0	0
357	R:R:A253	R:R:L247	1.58	No	Yes	0	5	8
358	R:R:A329	R:R:L330	1.58	No	No	0	3	4
359	L:L:E86	L:L:P85	1.57	No	No	0	0	0
360	L:L:C77	L:L:D81	1.56	Yes	No	0	0	0
361	R:R:I96	R:R:S48	1.55	No	No	0	7	4
362	R:R:I139	R:R:S135	1.55	No	No	0	5	6
363	R:R:I64	R:R:V61	1.54	No	No	0	7	9
364	R:R:I62	R:R:V83	1.54	No	No	0	7	6
365	R:R:I267	R:R:V263	1.54	No	No	0	5	4
366	L:L:K71	L:L:S51	1.53	No	No	0	0	0
367	R:R:K71	R:R:V153	1.52	No	No	0	6	2
368	R:R:M101	R:R:V106	1.52	No	No	0	4	3
369	R:R:M161	R:R:V165	1.52	No	No	0	4	4
370	R:R:M218	R:R:V222	1.52	No	No	0	1	4
371	R:R:K327	R:R:V328	1.52	No	No	0	6	3
372	R:R:M75	R:R:T72	1.51	Yes	No	0	8	7
373	R:R:F177	R:R:G213	1.51	Yes	No	0	4	3
374	L:L:G29	L:L:R28	1.5	No	No	0	0	0
375	L:L:G142	L:L:R140	1.5	No	No	0	0	0
376	R:R:K254	R:R:T255	1.5	No	No	0	5	6
377	R:R:K257	R:R:T255	1.5	No	No	0	7	6
378	L:L:L22	L:L:V56	1.49	No	No	0	0	0
379	R:R:L87	R:R:V90	1.49	Yes	No	0	7	5
380	R:R:L166	R:R:V162	1.49	No	No	0	4	4
381	R:R:L234	R:R:V233	1.49	No	No	0	4	5
382	R:R:N149	R:R:V145	1.48	No	No	0	4	5
383	R:R:K324	R:R:K325	1.44	No	No	0	8	5
384	L:L:Q74	L:L:V43	1.43	No	No	0	0	0
385	R:R:I49	R:R:L53	1.43	No	No	0	4	5
386	R:R:I55	R:R:L56	1.43	No	No	0	5	5
387	L:L:A141	L:L:F65	1.39	No	Yes	0	0	0
388	L:L:K79	L:L:Q44	1.36	No	No	0	0	0
389	R:R:N149	R:R:Q148	1.32	No	No	0	4	4
390	L:L:L136	R:R:H184	1.29	No	No	0	0	2
391	L:L:Q131	L:L:Q134	1.28	No	No	0	0	0
392	R:R:F42	R:R:I41	1.26	No	No	0	5	5
393	L:L:K103	L:L:R140	1.24	Yes	No	0	0	0
394	R:R:F259	R:R:K256	1.24	No	No	0	7	5
395	R:R:D179	R:R:F193	1.19	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L34	6.405	4	5	0
2	L:L:F65	5.334	5	0	0
3	L:L:L68	7.42	5	6	0
4	L:L:C77	4.2	4	5	0
5	L:L:W82	18.8975	4	5	0
6	L:L:R96	9.0775	4	0	0
7	L:L:K103	5.53	4	0	0
8	L:L:L114	5.602	5	8	0
9	L:L:Y149	4.966	5	1	0
10	L:L:F150	8.43	4	1	0
11	L:L:F154	6.988	5	1	0
12	L:L:S157	4.915	4	2	0
13	R:R:M75	3.2475	4	0	8
14	R:R:W77	5.77833	6	0	7
15	R:R:L87	3.8775	4	0	7
16	R:R:F88	6.42833	6	0	8
17	R:R:N89	5.21	5	10	6
18	R:R:I94	6.12	4	2	6
19	R:R:Y98	7.52	4	0	5
20	R:R:Y103	6.044	5	0	4
21	R:R:W105	8.155	4	2	9
22	R:R:C112	7.7225	4	2	9
23	R:R:F117	4.584	5	0	5
24	R:R:H121	6.082	5	13	5
25	R:R:M123	5.7575	4	0	8
26	R:R:F124	4.0175	4	0	7
27	R:R:V127	2.8625	4	3	7
28	R:R:R151	6.57	5	12	6
29	R:R:F177	4.3875	4	0	4
30	R:R:R178	7.02667	6	2	5
31	R:R:R224	5.65	4	0	5
32	R:R:F225	4.53	4	3	5
33	R:R:F229	5.9225	4	3	9
34	R:R:P232	3.3625	4	3	9
35	R:R:Y240	8.54167	6	4	9
36	R:R:L247	2.965	4	0	8
37	R:R:I265	7.355	4	4	8
38	R:R:F269	5.71	5	3	9
39	R:R:W273	7.594	5	3	9
40	R:R:E283	3.6775	4	1	4
41	R:R:F294	2.94333	6	1	5
42	R:R:Y316	7.27	5	4	9
43	R:R:D322	3.3825	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I102	L:L:Q26	37.4526	17.84	No	No	0	0	0
2	L:L:F70	L:L:L68	29.136	10.96	No	Yes	0	0	0
3	L:L:F70	L:L:L30	27.5969	9.74	No	No	0	0	0
4	L:L:L30	L:L:L34	26.7629	4.15	No	Yes	0	0	0
5	L:L:F47	L:L:L34	10.6124	6.09	No	Yes	0	0	0
6	L:L:F65	L:L:Q139	11.3527	3.51	Yes	No	0	0	0
7	L:L:F65	L:L:K103	24.1601	13.65	Yes	Yes	0	0	0
8	L:L:K103	L:L:K109	42.1403	2.87	Yes	No	0	0	0
9	L:L:G105	L:L:K109	40.5988	3.49	No	No	0	0	0
10	L:L:G105	L:L:L104	39.821	1.71	No	No	0	0	0
11	L:L:I102	L:L:L104	38.2514	2.85	No	No	0	0	0
12	L:L:E143	L:L:G142	64.2412	1.64	No	No	0	0	0
13	L:L:G142	L:L:R140	63.6227	1.5	No	No	0	0	0
14	L:L:K103	L:L:R140	62.9996	1.24	Yes	No	0	0	0
15	L:L:E143	L:L:S147	64.855	7.19	No	No	0	0	0
16	L:L:F150	L:L:Q153	69.5966	8.2	Yes	No	1	0	0
17	L:L:F150	R:R:L183	66.6682	10.96	Yes	No	0	0	1
18	L:L:F148	R:R:L183	66.0685	4.87	No	No	0	0	1
19	L:L:F148	L:L:S147	65.4641	6.61	No	No	0	0	0
20	L:L:F154	L:L:Q153	66.373	7.03	Yes	No	1	0	0
21	R:R:C112	R:R:R178	95.071	9.75	Yes	Yes	2	9	5
22	R:R:C112	R:R:W105	96.1018	9.14	Yes	Yes	2	9	9
23	R:R:W105	R:R:Y98	91.4117	10.61	Yes	Yes	0	9	5
24	R:R:Y103	R:R:Y98	90.2169	8.94	Yes	Yes	0	4	5
25	L:L:F154	R:R:Y103	87.2651	10.32	Yes	Yes	0	0	4
26	L:L:F156	R:R:M123	10.343	7.46	No	Yes	0	0	8
27	R:R:I120	R:R:M123	32.8398	4.37	No	Yes	0	4	8
28	R:R:I120	R:R:R224	86.6068	6.26	No	Yes	0	4	5
29	L:L:S157	R:R:R224	100	6.59	Yes	Yes	0	0	5
30	L:L:S157	R:R:R178	97.5261	2.64	Yes	Yes	2	0	5
31	R:R:F124	R:R:M123	19.4677	4.98	Yes	Yes	0	7	8
32	R:R:F124	R:R:R224	20.9905	3.21	Yes	Yes	0	7	5
33	R:R:F88	R:R:M123	38.2374	6.22	Yes	Yes	0	8	8
34	R:R:F88	R:R:N89	19.1093	4.83	Yes	Yes	0	8	6
35	R:R:G54	R:R:N89	10.343	3.39	No	Yes	0	8	6
36	R:R:I120	R:R:S171	85.2668	4.64	No	No	0	4	7
37	R:R:H121	R:R:S171	86.1711	6.97	Yes	No	0	5	7
38	R:R:A167	R:R:H121	89.5821	7.32	No	Yes	0	8	5
39	R:R:A167	R:R:F128	89.3525	2.77	No	No	0	8	6
40	R:R:F128	R:R:I163	89.1252	6.28	No	No	0	6	7
41	R:R:I132	R:R:I163	88.6426	2.94	No	No	0	6	7
42	R:R:I132	R:R:W77	88.3943	9.4	No	Yes	0	6	7
43	R:R:V73	R:R:W77	11.4815	6.13	No	Yes	0	6	7
44	R:R:R151	R:R:V73	10.6264	9.15	Yes	No	0	6	6
45	R:R:N74	R:R:R151	16.0006	3.62	No	Yes	0	8	6
46	R:R:F78	R:R:N74	14.2412	3.62	No	No	0	8	8
47	R:R:F78	R:R:V317	12.4772	7.87	No	No	0	8	7
48	R:R:D136	R:R:W77	11.4815	5.58	No	Yes	0	8	7
49	R:R:D136	R:R:R151	10.6264	9.53	No	Yes	0	8	6
50	R:R:V317	R:R:V61	10.7084	4.81	No	No	0	7	9
51	R:R:C160	R:R:W77	22.9607	3.92	No	Yes	0	7	7
52	R:R:C160	R:R:N80	22.1361	6.3	No	No	0	7	9
53	R:R:N80	R:R:V76	21.3068	4.43	No	No	0	9	6
54	R:R:V76	R:R:Y157	19.6341	8.83	No	No	0	6	3
55	R:R:K71	R:R:Y157	18.7907	2.39	No	No	0	6	3
56	R:R:K71	R:R:M75	17.0899	5.76	No	Yes	0	6	8
57	R:R:M69	R:R:M75	12.7559	2.89	No	Yes	0	5	8
58	R:R:D322	R:R:M69	10.9896	5.54	Yes	No	0	6	5
59	R:R:I133	R:R:W77	68.027	7.05	No	Yes	0	9	7
60	R:R:I133	R:R:R137	67.521	6.26	No	No	0	9	9
61	R:R:R137	R:R:Y316	27.6789	6.17	No	Yes	4	9	9
62	R:R:I94	R:R:W105	10.7436	7.05	Yes	Yes	2	6	9
63	R:R:R137	R:R:Y240	39.3267	4.12	No	Yes	4	9	9
64	R:R:S134	R:R:Y240	25.9031	12.72	No	Yes	0	9	9
65	R:R:I236	R:R:S134	13.4353	7.74	No	No	0	8	9
66	R:R:N312	R:R:Y316	16.4925	5.81	No	Yes	4	9	9
67	R:R:N308	R:R:N312	15.8834	10.9	No	No	0	9	9
68	R:R:N308	R:R:W273	13.768	7.91	No	Yes	0	9	9
69	R:R:C239	R:R:S134	14.6957	5.16	No	No	0	7	9
70	R:R:I265	R:R:Y240	11.1887	9.67	Yes	Yes	4	8	9
71	R:R:I261	R:R:I265	17.4202	2.94	No	Yes	0	8	8
72	R:R:I261	R:R:K257	14.2717	4.36	No	No	0	8	7
73	R:R:I265	R:R:Y316	10.945	9.67	Yes	Yes	4	8	9
74	R:R:R224	R:R:V220	14.5083	6.54	Yes	No	0	5	5
75	R:R:H277	R:R:W273	11.7228	8.46	No	Yes	3	8	9
76	L:L:L68	L:L:Q26	33.0717	18.63	Yes	No	6	0	0
77	L:L:F154	L:L:Y149	13.1519	7.22	Yes	Yes	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H146	R:R:G291	9.53	0	No	No	0	2	0	1
L:L:F148	R:R:L183	4.87	0	No	No	0	1	0	1
L:L:Y149	R:R:E283	5.61	1	Yes	Yes	0	4	0	1
L:L:Y149	R:R:F294	3.09	1	Yes	Yes	0	5	0	1
L:L:F150	R:R:A181	2.77	1	Yes	No	0	2	0	1
L:L:F150	R:R:L183	10.96	1	Yes	No	0	1	0	1
L:L:F150	R:R:F190	11.79	1	Yes	No	0	3	0	1
L:L:P151	R:R:E283	3.14	0	No	Yes	0	4	0	1
L:L:G152	R:R:N191	3.39	0	No	No	0	5	0	1
L:L:F154	R:R:Y103	10.32	1	Yes	Yes	0	4	0	1
L:L:F154	R:R:S295	7.93	1	Yes	No	0	4	0	1
L:L:F156	R:R:M123	7.46	0	No	Yes	0	8	0	1
L:L:F156	R:R:Y276	24.76	0	No	No	0	6	0	1
L:L:F156	R:R:T302	7.78	0	No	No	0	6	0	1
L:L:S157	R:R:R178	2.64	2	Yes	Yes	0	5	0	1
L:L:S157	R:R:N191	7.45	2	Yes	No	0	5	0	1
L:L:S157	R:R:R224	6.59	2	Yes	Yes	0	5	0	1
L:L:S157	R:R:N280	2.98	2	Yes	No	0	5	0	1
R:R:R40	R:R:Y103	4.12	0	No	Yes	4	4	2	1
R:R:T302	R:R:Y47	8.74	0	No	No	6	8	1	2
R:R:F88	R:R:M123	6.22	0	Yes	Yes	8	8	2	1
R:R:Y103	R:R:Y98	8.94	0	Yes	Yes	4	5	1	2
R:R:A99	R:R:Y103	2.67	0	No	Yes	5	4	2	1
R:R:P299	R:R:Y103	4.17	0	No	Yes	3	4	2	1
R:R:C112	R:R:N116	4.72	2	Yes	No	9	6	2	2
R:R:C112	R:R:R178	9.75	2	Yes	Yes	9	5	2	1
R:R:C112	R:R:C189	7.28	2	Yes	No	9	9	2	2
R:R:K113	R:R:R178	3.71	0	No	Yes	7	5	2	1
R:R:N116	R:R:R178	12.05	2	No	Yes	6	5	2	1
R:R:I120	R:R:M123	4.37	0	No	Yes	4	8	2	1
R:R:I120	R:R:R224	6.26	0	No	Yes	4	5	2	1
R:R:F124	R:R:M123	4.98	0	Yes	Yes	7	8	2	1
R:R:F124	R:R:R224	3.21	0	Yes	Yes	7	5	2	1
R:R:C189	R:R:R178	5.57	2	No	Yes	9	5	2	1
R:R:N191	R:R:R178	8.44	2	No	Yes	5	5	1	1
R:R:A181	R:R:F190	2.77	1	No	No	2	3	1	1
R:R:A181	R:R:L195	4.73	1	No	No	2	4	1	2
R:R:R224	R:R:V220	6.54	0	Yes	No	5	5	1	2
R:R:A301	R:R:Y276	4	0	No	No	7	6	2	1
R:R:L279	R:R:L298	8.3	0	No	No	4	4	2	1
R:R:E283	R:R:F294	3.5	1	Yes	Yes	4	5	1	1
R:R:F294	R:R:V293	3.93	1	Yes	No	5	1	1	2
R:R:E283	R:R:H217	2.46	1	Yes	No	4	4	1	2
L:L:F154	R:R:L298	2.44	1	Yes	No	0	4	0	1
R:R:F294	R:R:L282	2.44	1	Yes	No	5	5	1	2
R:R:F294	R:R:L298	2.44	1	Yes	No	5	4	1	1
R:R:F190	R:R:N192	2.42	1	No	No	3	2	1	2
R:R:F294	R:R:H286	2.26	1	Yes	No	5	2	1	2
R:R:G291	R:R:P290	2.03	0	No	No	2	1	1	2
L:L:L136	R:R:H184	1.29	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9L3W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	367
Number of Links	395
Number of Hubs	43
Number of Links mediated by Hubs	168
Number of Communities	14
Number of Nodes involved in Communities	70
Number of Links involved in Communities	83

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	82083
Length Of Smallest Path	3
Average Path Length	21.1475
Length of Longest Path	53
Minimum Path Strength	1.37
Average Path Strength	6.18913
Maximum Path Strength	29.505
Minimum Path Correlation	0.7
Average Path Correlation	0.968717
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.7027
Average % Of Corr. Nodes	63.7929
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9334
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • regulation of response to stimulus • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • locomotion • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • immune system process • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • antifungal innate immune response • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • innate immune response • response to external biotic stimulus • response to fungus • humoral immune response • antimicrobial humoral response • antifungal humoral response • cellular developmental process • cell differentiation • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • cellular response to peptide hormone stimulus • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • digestive system development • tube development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • metabolic process • regulation of phosphorylation • macromolecule metabolic process • regulation of metabolic process • inflammatory response • lipid catabolic process • catabolic process • regulation of lipid metabolic process • regulation of catabolic process • regulation of lipid catabolic process • lipid metabolic process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • platelet dense granule lumen • cytoplasmic vesicle • platelet dense granule • secretory granule • secretory vesicle • extracellular matrix • external encapsulating structure • collagen-containing extracellular matrix • amide binding • adipokinetic hormone binding • peptide hormone binding • hormone binding • molecular transducer activity • signaling receptor activity • protein-hormone receptor activity • adipokinetic hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled chemoattractant receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • complement receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • skeletal system development • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • negative regulation of DNA-binding transcription factor activity • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • negative regulation of NF-kappaB transcription factor activity • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • negative regulation of molecular function • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of molecular function • regulation of gene expression • biosynthetic process • regulation of DNA-binding transcription factor activity • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of signaling • regulation of signal transduction • regulation of intracellular signal transduction • calcium-mediated signaling • regulation of calcium-mediated signaling • regulation of cell communication • negative regulation of biological process • regulation of interleukin-12 production • negative regulation of interleukin-12 production • cytokine production • negative regulation of cellular process • regulation of cytokine production • interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of multicellular organismal process
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99788
Sequence	>9L3W_nogp_Chain_R E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K M K K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D Y H W V F G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L P V W S Q N H R S V R L A Y M A C M V I W V L A F F L S S P S L V F R D T A N L H G K I S C F N N F S L P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R L A K T K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H T A M P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D F K K F K V A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9L3Z	A	Protein	Chemerin	CML1	Homo sapiens	LRH7-C2	-	-	3.9	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3W	A	Protein	Chemerin	CML1	Homo sapiens	Retinoic acid receptor responder protein 2	-	Gi1/β1/γ2	3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3W (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Retinoic acid receptor responder protein 2	-		3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	8ZJG	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	8ZJG (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	8SG1	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.94	2023-11-01	10.1371/journal.pbio.3002188
	8SG1 (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.94	2023-11-01	10.1371/journal.pbio.3002188
	7YKD	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.81	2023-04-19	10.1073/pnas.2214324120
	7YKD (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.81	2023-04-19	10.1073/pnas.2214324120

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