psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D20	R:R:L22	4.07	No	Yes	3	3	4
2	L:L:C77	R:R:D20	6.22	No	No	0	9	3
3	L:L:R96	R:R:D20	10.72	Yes	No	3	7	3
4	L:L:I119	R:R:Y21	16.92	Yes	No	0	4	7
5	L:L:L34	R:R:L22	2.77	No	Yes	0	8	4
6	L:L:F37	R:R:L22	6.09	Yes	Yes	3	8	4
7	L:L:R96	R:R:L22	7.29	Yes	Yes	3	7	4
8	L:L:C117	R:R:L22	3.17	Yes	Yes	3	9	4
9	L:L:L114	R:R:S24	3	No	No	0	7	4
10	L:L:H116	R:R:S24	9.76	No	No	0	8	4
11	R:R:I25	R:R:V27	3.07	No	No	3	5	3
12	L:L:F37	R:R:I25	8.79	Yes	No	3	8	5
13	L:L:R113	R:R:I25	2.51	Yes	No	3	7	5
14	R:R:E29	R:R:V26	14.26	No	No	0	7	7
15	L:L:R113	R:R:V27	18.31	Yes	No	3	7	3
16	R:R:D30	R:R:L28	2.71	No	No	0	2	4
17	R:R:E29	R:R:L31	9.28	No	No	0	7	4
18	R:R:E35	R:R:S32	2.87	No	No	0	3	4
19	R:R:E35	R:R:L34	3.98	No	No	0	3	3
20	R:R:R37	R:R:R40	11.73	No	No	0	3	4
21	R:R:L43	R:R:T39	2.95	No	No	0	6	4
22	R:R:D102	R:R:R40	10.72	No	No	0	4	4
23	R:R:F42	R:R:V46	2.62	No	No	0	5	5
24	R:R:L43	R:R:Y47	4.69	No	Yes	0	6	8
25	R:R:L300	R:R:L43	2.77	No	No	0	5	6
26	R:R:I49	R:R:V45	3.07	No	No	0	4	5
27	R:R:V46	R:R:Y47	2.52	No	Yes	0	5	8
28	R:R:I96	R:R:Y47	3.63	No	Yes	0	7	8
29	R:R:T302	R:R:Y47	4.99	No	Yes	0	6	8
30	R:R:A303	R:R:Y47	5.34	No	Yes	0	5	8
31	R:R:I306	R:R:Y47	3.63	Yes	Yes	0	7	8
32	R:R:I306	R:R:V50	3.07	Yes	No	0	7	7
33	R:R:C51	R:R:L92	3.17	No	Yes	0	6	8
34	R:R:G54	R:R:N89	3.39	No	Yes	0	8	6
35	R:R:F86	R:R:I55	5.02	Yes	No	0	8	5
36	R:R:G57	R:R:L56	3.42	No	No	0	7	5
37	R:R:L56	R:R:L60	2.77	No	No	0	5	6
38	R:R:D85	R:R:N58	8.08	Yes	Yes	0	9	9
39	R:R:F86	R:R:N58	3.62	Yes	Yes	0	8	9
40	R:R:N58	R:R:N89	4.09	Yes	Yes	0	9	6
41	R:R:N58	R:R:P313	4.89	Yes	No	0	9	9
42	R:R:I63	R:R:L60	2.85	No	No	0	3	6
43	R:R:A82	R:R:V61	3.39	No	No	0	8	9
44	R:R:V317	R:R:V61	6.41	Yes	No	5	7	9
45	R:R:F318	R:R:V61	3.93	Yes	No	5	6	9
46	R:R:A82	R:R:I62	3.25	No	No	0	8	7
47	R:R:F86	R:R:I62	3.77	Yes	No	0	8	7
48	R:R:F67	R:R:T66	3.89	No	No	0	5	4
49	R:R:F67	R:R:K68	2.48	No	No	0	5	4
50	R:R:F326	R:R:K68	3.72	No	No	0	4	4
51	R:R:M69	R:R:M75	2.89	Yes	No	5	5	8
52	R:R:D322	R:R:M69	5.54	No	Yes	0	6	5
53	R:R:K71	R:R:M75	7.2	No	No	0	6	8
54	R:R:R151	R:R:V73	10.46	No	No	0	6	6
55	R:R:F78	R:R:N74	3.62	Yes	No	0	8	8
56	R:R:A156	R:R:V76	5.09	No	No	0	7	6
57	R:R:V76	R:R:Y157	11.36	No	Yes	0	6	3
58	R:R:C160	R:R:V76	3.42	No	No	0	7	6
59	R:R:I132	R:R:W77	9.4	No	Yes	0	6	7
60	R:R:I133	R:R:W77	3.52	No	Yes	0	9	7
61	R:R:D136	R:R:W77	6.7	No	Yes	0	8	7
62	R:R:A156	R:R:W77	5.19	No	Yes	0	7	7
63	R:R:A159	R:R:W77	2.59	No	Yes	0	5	7
64	R:R:C160	R:R:W77	2.61	No	Yes	0	7	7
65	R:R:F78	R:R:I133	2.51	Yes	No	0	8	9
66	R:R:F78	R:R:Y316	3.09	Yes	Yes	0	8	9
67	R:R:F78	R:R:V317	2.62	Yes	Yes	0	8	7
68	R:R:L129	R:R:N80	4.12	No	No	0	8	9
69	R:R:C160	R:R:N80	11.02	No	No	0	7	9
70	R:R:N80	R:R:W164	5.65	No	Yes	0	9	9
71	R:R:D85	R:R:L81	2.71	Yes	Yes	2	9	9
72	R:R:L81	R:R:S126	3	Yes	No	2	9	9
73	R:R:L129	R:R:L81	4.15	No	Yes	0	8	9
74	R:R:L130	R:R:L81	5.54	Yes	Yes	2	8	9
75	R:R:L81	R:R:N312	5.49	Yes	Yes	2	9	9
76	R:R:V83	R:R:W164	2.45	No	Yes	0	6	9
77	R:R:A84	R:R:T125	3.36	No	Yes	7	8	7
78	R:R:A84	R:R:W164	2.59	No	Yes	7	8	9
79	R:R:D85	R:R:S126	5.89	Yes	No	2	9	9
80	R:R:D85	R:R:S309	4.42	Yes	No	0	9	9
81	R:R:D85	R:R:N312	6.73	Yes	Yes	2	9	9
82	R:R:F86	R:R:V90	7.87	Yes	No	0	8	5
83	R:R:L87	R:R:N122	6.87	No	No	0	7	8
84	R:R:F88	R:R:N89	3.62	Yes	Yes	0	8	6
85	R:R:F88	R:R:L119	3.65	Yes	No	0	8	6
86	R:R:F88	R:R:N122	6.04	Yes	No	0	8	8
87	R:R:F88	R:R:M123	3.73	Yes	No	0	8	8
88	R:R:N89	R:R:S309	2.98	Yes	No	0	6	9
89	R:R:F91	R:R:V90	2.62	No	No	0	6	5
90	R:R:F91	R:R:L118	13.4	No	No	0	6	5
91	R:R:I96	R:R:L92	5.71	No	Yes	0	7	8
92	R:R:I306	R:R:L92	2.85	Yes	Yes	9	7	8
93	L:L:F156	R:R:L92	3.65	Yes	Yes	9	9	8
94	R:R:I96	R:R:P93	3.39	No	No	0	7	8
95	R:R:F107	R:R:I94	2.51	Yes	No	1	8	6
96	R:R:I94	R:R:M111	4.37	No	No	1	6	6
97	R:R:I94	R:R:S115	3.1	No	No	0	6	5
98	R:R:F107	R:R:T97	2.59	Yes	No	0	8	4
99	R:R:Y103	R:R:Y98	7.94	Yes	No	0	4	5
100	R:R:W105	R:R:Y98	10.61	Yes	No	0	9	5
101	R:R:A99	R:R:Y103	5.34	No	Yes	0	5	4
102	R:R:M101	R:R:V106	3.04	No	No	0	4	3
103	R:R:P299	R:R:Y103	2.78	No	Yes	0	3	4
104	L:L:F154	R:R:Y103	11.35	Yes	Yes	0	6	4
105	R:R:H104	R:R:V106	2.77	No	No	0	5	3
106	R:R:H104	R:R:K186	3.93	No	No	0	5	2
107	R:R:H104	R:R:I187	5.3	No	No	0	5	5
108	R:R:F107	R:R:W105	19.04	Yes	Yes	1	8	9
109	R:R:G108	R:R:W105	2.81	No	Yes	0	8	9
110	R:R:C112	R:R:W105	18.28	No	Yes	1	9	9
111	R:R:C189	R:R:W105	3.92	No	Yes	1	9	9
112	R:R:F107	R:R:V106	3.93	Yes	No	0	8	3
113	R:R:F107	R:R:M111	6.22	Yes	No	1	8	6
114	R:R:K113	R:R:T109	6.01	No	No	0	7	3
115	R:R:C112	R:R:C189	7.28	No	No	1	9	9
116	R:R:K113	R:R:L175	7.05	No	No	0	7	4
117	R:R:K113	R:R:R178	2.48	No	Yes	0	7	5
118	R:R:I114	R:R:L118	2.85	No	No	0	4	5
119	R:R:N116	R:R:S115	4.47	No	No	0	6	5
120	R:R:N116	R:R:R178	9.64	No	Yes	0	6	5
121	R:R:F117	R:R:L118	3.65	Yes	No	0	5	5
122	R:R:F117	R:R:F168	6.43	Yes	No	0	5	3
123	R:R:F117	R:R:S171	7.93	Yes	No	0	5	7
124	R:R:F117	R:R:S174	2.64	Yes	No	11	5	5
125	R:R:F117	R:R:L175	12.18	Yes	No	11	5	4
126	L:L:F156	R:R:L119	4.87	Yes	No	0	9	6
127	R:R:I120	R:R:M123	2.92	Yes	No	0	4	8
128	R:R:F124	R:R:I120	2.51	Yes	Yes	1	7	4
129	R:R:I120	R:R:S171	6.19	Yes	No	0	4	7
130	R:R:I120	R:R:R224	6.26	Yes	Yes	1	4	5
131	L:L:S157	R:R:I120	3.1	Yes	Yes	1	5	4
132	R:R:H121	R:R:T125	5.48	Yes	Yes	7	5	7
133	R:R:H121	R:R:W164	8.46	Yes	Yes	7	5	9
134	R:R:A167	R:R:H121	2.93	No	Yes	0	8	5
135	R:R:F168	R:R:H121	3.39	No	Yes	0	3	5
136	R:R:H121	R:R:S171	4.18	Yes	No	0	5	7
137	R:R:M123	R:R:W273	8.14	No	Yes	0	8	9
138	R:R:F124	R:R:L170	14.61	Yes	Yes	0	7	5
139	R:R:F124	R:R:R224	4.28	Yes	Yes	1	7	5
140	R:R:F124	R:R:G228	3.01	Yes	No	0	7	6
141	R:R:L129	R:R:T125	2.95	No	Yes	0	8	7
142	R:R:T125	R:R:W164	15.77	Yes	Yes	7	7	9
143	R:R:P232	R:R:V127	3.53	Yes	No	0	9	7
144	R:R:V127	R:R:W273	3.68	No	Yes	0	7	9
145	R:R:F128	R:R:I163	5.02	No	No	0	6	7
146	R:R:L130	R:R:N308	2.75	Yes	Yes	2	8	9
147	R:R:L130	R:R:N312	12.36	Yes	Yes	2	8	9
148	R:R:L130	R:R:Y316	4.69	Yes	Yes	0	8	9
149	R:R:P232	R:R:T131	3.5	Yes	No	0	9	7
150	R:R:I235	R:R:T131	4.56	No	No	0	7	7
151	R:R:I133	R:R:R137	3.76	No	No	0	9	9
152	R:R:S134	R:R:S135	3.26	Yes	No	0	9	6
153	R:R:I236	R:R:S134	4.64	No	Yes	0	8	9
154	R:R:C239	R:R:S134	3.44	No	Yes	0	7	9
155	R:R:S134	R:R:Y240	3.82	Yes	Yes	0	9	9
156	R:R:D136	R:R:R151	7.15	No	No	0	8	6
157	R:R:R137	R:R:Y240	7.2	No	Yes	0	9	9
158	R:R:R137	R:R:Y316	8.23	No	Yes	0	9	9
159	R:R:C138	R:R:C239	7.28	No	No	0	8	7
160	R:R:C138	R:R:I243	3.27	No	No	0	8	8
161	R:R:I139	R:R:L143	2.85	No	No	0	5	6
162	R:R:I243	R:R:V141	6.14	No	No	0	8	8
163	R:R:L142	R:R:L143	2.77	No	No	0	7	6
164	R:R:L142	R:R:T242	2.95	No	No	0	7	4
165	R:R:H150	R:R:W146	16.93	No	No	0	4	4
166	R:R:R151	R:R:S147	3.95	No	No	0	6	4
167	R:R:H150	R:R:N149	6.38	No	No	0	4	4
168	R:R:L155	R:R:S152	4.5	No	No	0	3	6
169	R:R:V153	R:R:Y157	3.79	No	Yes	0	2	3
170	R:R:M158	R:R:R154	3.72	No	No	0	3	5
171	R:R:F169	R:R:L166	3.65	No	No	0	3	4
172	R:R:P173	R:R:S172	3.56	No	No	0	8	4
173	R:R:P173	R:R:V220	7.07	No	Yes	1	8	5
174	R:R:P173	R:R:R224	11.53	No	Yes	1	8	5
175	R:R:L175	R:R:S174	6.01	No	No	11	4	5
176	R:R:F177	R:R:V176	9.18	Yes	No	0	4	4
177	R:R:F177	R:R:F193	23.58	Yes	Yes	1	4	5
178	R:R:F177	R:R:R216	4.28	Yes	Yes	1	4	4
179	R:R:F177	R:R:V220	2.62	Yes	Yes	1	4	5
180	R:R:C189	R:R:R178	6.96	No	Yes	1	9	5
181	R:R:N191	R:R:R178	6.03	Yes	Yes	1	5	5
182	L:L:S157	R:R:R178	6.59	Yes	Yes	1	5	5
183	R:R:D179	R:R:N192	12.12	No	Yes	4	4	2
184	R:R:D179	R:R:P198	3.22	No	Yes	4	4	4
185	R:R:I187	R:R:T180	6.08	No	No	0	5	4
186	R:R:H184	R:R:L183	10.29	No	No	0	2	1
187	L:L:F150	R:R:L183	3.65	Yes	No	0	4	1
188	L:L:F60	R:R:H184	4.53	Yes	No	6	4	2
189	L:L:Q139	R:R:H184	27.2	Yes	No	6	5	2
190	L:L:R137	R:R:K186	13.61	No	No	10	5	2
191	L:L:R140	R:R:K186	8.66	No	No	10	4	2
192	R:R:F190	R:R:S188	2.64	Yes	No	4	3	4
193	L:L:F150	R:R:S188	2.64	Yes	No	4	4	4
194	L:L:Q153	R:R:S188	7.22	Yes	No	4	6	4
195	R:R:F190	R:R:N192	6.04	Yes	Yes	4	3	2
196	L:L:F150	R:R:F190	17.15	Yes	Yes	4	4	3
197	R:R:F193	R:R:N191	12.08	Yes	Yes	1	5	5
198	L:L:G152	R:R:N191	5.09	No	Yes	0	9	5
199	L:L:S157	R:R:N191	4.47	Yes	Yes	1	5	5
200	R:R:N192	R:R:T197	8.77	Yes	No	4	2	3
201	R:R:N192	R:R:P198	4.89	Yes	Yes	4	2	4
202	R:R:F193	R:R:R216	3.21	Yes	Yes	1	5	4
203	R:R:F193	R:R:H217	16.97	Yes	Yes	1	5	4
204	R:R:F193	R:R:V220	6.55	Yes	Yes	1	5	5
205	R:R:S194	R:R:S196	3.26	Yes	No	0	3	2
206	R:R:M209	R:R:S194	6.13	No	Yes	0	5	3
207	R:R:S194	R:R:V212	3.23	Yes	No	0	3	3
208	R:R:L195	R:R:P198	4.93	No	Yes	0	4	4
209	R:R:L195	R:R:R216	4.86	No	Yes	0	4	4
210	R:R:S196	R:R:S201	4.89	No	No	0	2	7
211	R:R:P198	R:R:T197	3.5	Yes	No	4	4	3
212	R:R:G199	R:R:S200	3.71	No	No	0	3	6
213	R:R:T205	R:R:W203	7.28	No	Yes	0	5	7
214	R:R:M209	R:R:W203	3.49	No	Yes	0	5	7
215	L:L:F150	R:R:W203	3.01	Yes	Yes	0	4	7
216	R:R:H206	R:R:P204	4.58	No	No	0	5	5
217	R:R:Q208	R:R:S207	4.33	No	No	13	7	5
218	R:R:S207	R:R:Y214	2.54	No	No	13	5	1
219	R:R:S207	R:R:T287	4.8	No	No	0	5	1
220	R:R:Q208	R:R:Y214	4.51	No	No	13	7	1
221	R:R:D210	R:R:P211	4.83	No	No	0	4	2
222	R:R:P211	R:R:V212	3.53	No	No	0	2	3
223	R:R:R216	R:R:V212	7.85	Yes	No	0	4	3
224	R:R:H217	R:R:T221	6.85	Yes	No	1	4	6
225	R:R:H217	R:R:L284	3.86	Yes	No	1	4	5
226	L:L:P151	R:R:H217	4.58	No	Yes	0	9	4
227	R:R:R224	R:R:V220	6.54	Yes	Yes	1	5	5
228	R:R:L284	R:R:T221	7.37	No	No	1	5	6
229	L:L:S157	R:R:R224	3.95	Yes	Yes	1	5	5
230	R:R:F225	R:R:F229	4.29	No	Yes	2	5	9
231	R:R:F225	R:R:H277	6.79	No	No	2	5	8
232	R:R:L226	R:R:L230	2.77	No	No	0	4	4
233	R:R:F229	R:R:F270	5.36	Yes	No	2	9	6
234	R:R:C274	R:R:F229	4.19	No	Yes	2	6	9
235	R:R:F229	R:R:H277	4.53	Yes	No	2	9	8
236	R:R:P232	R:R:V231	3.53	Yes	No	0	9	6
237	R:R:I235	R:R:V231	3.07	No	No	0	7	6
238	R:R:F269	R:R:P232	2.89	Yes	Yes	0	9	9
239	R:R:L234	R:R:V233	2.98	No	No	0	4	5
240	R:R:F269	R:R:V233	5.24	Yes	No	0	9	5
241	R:R:F269	R:R:I236	2.51	Yes	No	0	9	8
242	R:R:L241	R:R:T237	2.95	No	No	0	3	4
243	R:R:I262	R:R:Y240	10.88	No	Yes	12	8	9
244	R:R:I265	R:R:Y240	7.25	Yes	Yes	0	8	9
245	R:R:I266	R:R:Y240	4.84	No	Yes	12	8	9
246	R:R:F259	R:R:V244	6.55	No	No	0	7	5
247	R:R:I262	R:R:V244	4.61	No	No	0	8	5
248	R:R:K246	R:R:N250	2.8	No	No	0	5	5
249	R:R:L247	R:R:L252	2.77	No	No	0	8	3
250	R:R:L247	R:R:P258	3.28	No	No	0	8	7
251	R:R:N250	R:R:R249	10.85	No	No	0	5	5
252	R:R:L252	R:R:N250	2.75	No	No	0	3	5
253	R:R:A253	R:R:F259	2.77	No	No	0	5	7
254	R:R:K256	R:R:K260	2.87	No	No	0	5	5
255	R:R:K257	R:R:P258	3.35	No	No	0	7	7
256	R:R:I261	R:R:I265	2.94	No	Yes	0	8	8
257	R:R:I261	R:R:M319	2.92	No	No	0	8	6
258	R:R:I262	R:R:I266	2.94	No	No	12	8	8
259	R:R:I265	R:R:L315	4.28	Yes	No	0	8	7
260	R:R:I265	R:R:Y316	6.04	Yes	Yes	0	8	9
261	R:R:M311	R:R:T268	6.02	No	No	0	6	7
262	R:R:F269	R:R:W273	8.02	Yes	Yes	2	9	9
263	R:R:F269	R:R:N308	3.62	Yes	Yes	2	9	9
264	R:R:C274	R:R:F270	5.59	No	No	2	6	6
265	R:R:W273	R:R:Y276	2.89	Yes	No	0	9	6
266	R:R:A305	R:R:W273	3.89	No	Yes	0	8	9
267	R:R:N308	R:R:W273	10.17	Yes	Yes	2	9	9
268	R:R:N280	R:R:Y276	15.12	No	No	0	5	6
269	L:L:F156	R:R:Y276	3.09	Yes	No	0	9	6
270	R:R:L279	R:R:L298	5.54	No	No	0	4	4
271	R:R:E283	R:R:N280	3.94	Yes	No	0	4	5
272	R:R:L282	R:R:M289	9.9	No	No	0	5	3
273	R:R:E283	R:R:F294	4.66	Yes	Yes	0	4	5
274	R:R:E283	R:R:L298	3.98	Yes	No	0	4	4
275	L:L:Y149	R:R:E283	5.61	Yes	Yes	0	5	4
276	L:L:G152	R:R:E283	3.27	No	Yes	0	9	4
277	R:R:H285	R:R:T287	6.85	No	No	0	5	1
278	R:R:A288	R:R:H285	2.93	No	No	0	1	5
279	L:L:Y149	R:R:H286	4.36	Yes	No	0	5	2
280	R:R:F294	R:R:M289	2.49	Yes	No	0	5	3
281	R:R:P290	R:R:V293	5.3	No	No	0	1	1
282	L:L:H146	R:R:G291	7.94	No	No	0	5	2
283	R:R:F294	R:R:V293	3.93	Yes	No	0	5	1
284	L:L:H146	R:R:F294	9.05	No	Yes	0	5	5
285	L:L:F154	R:R:S295	2.64	Yes	No	0	6	4
286	L:L:F156	R:R:T302	10.38	Yes	No	0	9	6
287	L:L:F156	R:R:I306	5.02	Yes	Yes	9	9	7
288	R:R:N308	R:R:N312	5.45	Yes	Yes	2	9	9
289	R:R:F318	R:R:I314	3.77	Yes	No	0	6	6
290	R:R:F318	R:R:V317	3.93	Yes	Yes	5	6	7
291	R:R:F318	R:R:F323	26.79	Yes	No	5	6	8
292	R:R:K324	R:R:Q321	2.71	No	No	0	8	5
293	R:R:F323	R:R:K327	2.48	No	No	0	8	6
294	R:R:F326	R:R:L330	19.49	No	No	0	4	4
295	R:R:F331	R:R:V335	3.93	No	No	0	5	3
296	L:L:E21	L:L:K71	5.4	No	Yes	0	4	4
297	L:L:E24	L:L:L22	7.95	No	No	0	3	6
298	L:L:L22	L:L:R27	10.93	No	Yes	14	6	4
299	L:L:K71	L:L:L22	9.87	Yes	No	14	4	6
300	L:L:Q26	L:L:T23	8.5	No	No	0	8	6
301	L:L:Q26	L:L:R27	4.67	No	Yes	0	8	4
302	L:L:Q26	L:L:V66	7.16	No	Yes	0	8	9
303	L:L:Q31	L:L:R27	15.19	No	Yes	0	4	4
304	L:L:K71	L:L:R27	13.61	Yes	Yes	14	4	4
305	L:L:G29	L:L:V32	3.68	No	No	0	6	6
306	L:L:I102	L:L:L30	7.14	Yes	No	0	5	8
307	L:L:L104	L:L:L30	8.3	Yes	No	0	9	8
308	L:L:V32	L:L:W82	6.13	No	Yes	0	6	5
309	L:L:L34	L:L:V115	2.98	No	No	0	8	3
310	L:L:E35	L:L:H38	6.15	No	No	0	6	9
311	L:L:E35	L:L:R78	3.49	No	No	0	6	2
312	L:L:E35	L:L:W82	31.62	No	Yes	0	6	5
313	L:L:E36	L:L:R113	10.47	No	Yes	0	5	7
314	L:L:F37	L:L:R113	8.55	Yes	Yes	3	8	7
315	L:L:K39	L:L:R80	21.04	No	No	0	4	5
316	L:L:R67	L:L:S54	5.27	No	No	0	6	4
317	L:L:F70	L:L:S54	10.57	No	No	0	6	4
318	L:L:A55	L:L:L68	4.73	No	No	0	6	8
319	L:L:R67	L:L:V56	9.15	No	No	0	6	1
320	L:L:D57	L:L:P59	3.22	No	No	0	6	2
321	L:L:D57	L:L:I64	15.39	No	No	8	6	8
322	L:L:D57	L:L:V66	7.3	No	Yes	8	6	9
323	L:L:F60	L:L:T58	3.89	Yes	No	6	4	3
324	L:L:F65	L:L:T58	3.89	Yes	No	6	8	3
325	L:L:F60	L:L:F65	3.22	Yes	Yes	6	4	8
326	L:L:F60	L:L:Q139	10.54	Yes	Yes	6	4	5
327	L:L:A62	L:L:E143	4.53	No	No	0	7	6
328	L:L:I64	L:L:V66	3.07	No	Yes	8	8	9
329	L:L:I64	L:L:L104	9.99	No	Yes	8	8	9
330	L:L:C101	L:L:F65	5.59	No	Yes	0	9	8
331	L:L:F65	L:L:V138	2.62	Yes	No	0	8	8
332	L:L:F65	L:L:Q139	7.03	Yes	Yes	6	8	5
333	L:L:I102	L:L:V66	3.07	Yes	Yes	0	5	9
334	L:L:L104	L:L:V66	2.98	Yes	Yes	8	9	9
335	L:L:E69	L:L:R67	16.28	No	No	0	7	6
336	L:L:K71	L:L:L68	2.82	Yes	No	0	4	8
337	L:L:E69	L:L:F70	4.66	No	No	0	7	6
338	L:L:F70	L:L:K97	2.48	No	Yes	0	6	4
339	L:L:K71	L:L:L72	9.87	Yes	No	0	4	8
340	L:L:K97	L:L:Q74	14.92	Yes	No	0	4	9
341	L:L:R78	L:L:T75	14.23	No	No	0	2	9
342	L:L:D81	L:L:K79	4.15	No	No	0	5	9
343	L:L:R80	L:L:W82	8	No	Yes	0	5	5
344	L:L:D81	L:L:K84	8.3	No	No	0	5	4
345	L:L:K84	L:L:P85	3.35	No	No	0	4	4
346	L:L:K97	L:L:R96	2.48	Yes	Yes	3	4	7
347	L:L:C98	L:L:R96	2.79	Yes	Yes	3	8	7
348	L:L:C117	L:L:R96	2.79	Yes	Yes	3	9	7
349	L:L:I119	L:L:R96	2.51	Yes	Yes	3	4	7
350	L:L:I119	L:L:K97	5.82	Yes	Yes	3	4	4
351	L:L:C117	L:L:C98	7.28	Yes	Yes	3	9	8
352	L:L:C98	L:L:I119	6.55	Yes	Yes	3	8	4
353	L:L:C135	L:L:L99	4.76	No	No	0	9	7
354	L:L:A100	L:L:V115	5.09	No	No	0	8	3
355	L:L:C101	L:L:C135	7.28	No	No	0	9	9
356	L:L:I102	L:L:R113	3.76	Yes	Yes	0	5	7
357	L:L:K103	L:L:L111	8.46	No	No	0	9	8
358	L:L:E143	L:L:K103	8.1	No	No	0	6	9
359	L:L:G105	L:L:L104	3.42	No	Yes	0	5	9
360	L:L:K109	L:L:S106	7.65	No	No	0	4	1
361	L:L:D108	L:L:E107	6.5	No	No	0	4	1
362	L:L:R113	L:L:V115	2.62	Yes	No	0	7	3
363	L:L:H116	L:L:P118	10.68	No	No	0	8	7
364	L:L:E129	L:L:H130	8.62	No	No	0	3	4
365	L:L:E129	L:L:T133	9.88	No	No	0	3	4
366	L:L:Q134	L:L:R137	12.85	No	No	0	6	5
367	L:L:L136	L:L:Q139	5.32	No	Yes	0	3	5
368	L:L:R137	L:L:R140	4.26	No	No	10	5	4
369	L:L:D144	L:L:S147	4.42	No	No	0	4	3
370	L:L:H146	L:L:Y149	3.27	No	Yes	0	5	5
371	L:L:Q153	L:L:Y149	5.64	Yes	Yes	4	6	5
372	L:L:F154	L:L:Y149	6.19	Yes	Yes	4	6	5
373	L:L:F150	L:L:Q153	8.2	Yes	Yes	4	4	6
374	L:L:F154	L:L:Q153	8.2	Yes	Yes	4	6	6
375	R:R:F318	R:R:L60	2.44	Yes	No	0	6	6
376	R:R:F128	R:R:L170	2.44	No	Yes	0	6	5
377	R:R:F169	R:R:L170	2.44	No	Yes	0	3	5
378	R:R:F225	R:R:L226	2.44	No	No	0	5	4
379	R:R:F229	R:R:L230	2.44	Yes	No	0	9	4
380	L:L:D81	L:L:R80	2.38	No	No	0	5	5
381	R:R:I139	R:R:W146	2.35	No	No	0	5	4
382	L:L:E24	L:L:R28	2.33	No	No	0	3	7
383	L:L:K83	L:L:W82	2.32	No	Yes	0	4	5
384	R:R:H95	R:R:Y98	2.18	No	No	0	6	5
385	L:L:E36	L:L:W82	2.18	No	Yes	0	5	5
386	L:L:G105	L:L:G63	2.11	No	No	0	5	9
387	R:R:F229	R:R:W273	2	Yes	Yes	2	9	9
388	R:R:C310	R:R:G54	1.96	No	No	0	8	8
389	R:R:C274	R:R:P275	1.88	No	No	0	6	9
390	L:L:C98	L:L:P118	1.88	Yes	No	3	8	7
391	L:L:C117	L:L:P118	1.88	Yes	No	3	9	7
392	R:R:A301	R:R:P275	1.87	No	No	0	7	9
393	R:R:G213	R:R:S194	1.86	No	Yes	0	3	3
394	L:L:G112	L:L:V138	1.84	No	No	0	5	8
395	L:L:T133	R:R:G185	1.82	No	No	0	4	6
396	R:R:P33	R:R:S32	1.78	No	No	0	3	4
397	L:L:P59	L:L:T58	1.75	No	No	0	2	3
398	L:L:G63	L:L:K103	1.74	No	No	0	9	9
399	L:L:C77	L:L:S76	1.72	No	No	0	9	3
400	R:R:G54	R:R:L53	1.71	No	No	0	8	5
401	R:R:G297	R:R:L279	1.71	No	No	0	5	4
402	L:L:G142	L:L:L111	1.71	No	No	0	6	8
403	R:R:A99	R:R:V44	1.7	No	No	0	5	5
404	L:L:A141	L:L:V138	1.7	No	No	0	6	8
405	R:R:C272	R:R:T268	1.69	No	No	0	9	7
406	R:R:A100	R:R:T97	1.68	No	No	0	5	4
407	R:R:L143	R:R:P144	1.64	No	No	0	6	8
408	R:R:L304	R:R:P275	1.64	No	No	0	7	9
409	L:L:A33	L:L:I102	1.62	No	Yes	0	7	5
410	R:R:A65	R:R:M69	1.61	No	Yes	0	6	5
411	L:L:D144	L:L:P145	1.61	No	No	0	4	1
412	L:L:S147	R:R:T205	1.6	No	No	0	3	5
413	R:R:C138	R:R:L142	1.59	No	No	0	8	7
414	R:R:C227	R:R:L170	1.59	No	Yes	0	4	5
415	R:R:T223	R:R:V219	1.59	No	No	0	4	3
416	R:R:T223	R:R:V222	1.59	No	No	0	4	4
417	R:R:A65	R:R:L79	1.58	No	No	0	6	5
418	L:L:A155	R:R:L298	1.58	No	No	0	9	4
419	R:R:A329	R:R:L330	1.58	No	No	0	3	4
420	R:R:A337	R:R:L334	1.58	No	No	0	3	5
421	R:R:C272	R:R:N308	1.57	No	Yes	0	9	9
422	R:R:I49	R:R:S48	1.55	No	No	0	4	4
423	R:R:I41	R:R:V45	1.54	No	No	0	5	5
424	R:R:I267	R:R:V263	1.54	No	No	0	5	4
425	R:R:I62	R:R:T66	1.52	No	No	0	7	4
426	R:R:M69	R:R:V317	1.52	Yes	Yes	5	5	7
427	R:R:K246	R:R:V141	1.52	No	No	0	5	8
428	R:R:M218	R:R:V222	1.52	No	No	0	1	4
429	R:R:I266	R:R:T237	1.52	No	No	0	8	4
430	R:R:I265	R:R:T264	1.52	Yes	No	0	8	5
431	R:R:K327	R:R:V328	1.52	No	No	0	6	3
432	R:R:A36	R:R:E35	1.51	No	No	0	4	3
433	R:R:M69	R:R:T72	1.51	Yes	No	5	5	7
434	R:R:M75	R:R:T72	1.51	No	No	5	8	7
435	R:R:K70	R:R:T72	1.5	No	No	0	6	7
436	R:R:K254	R:R:T255	1.5	No	No	0	5	6
437	R:R:K257	R:R:T255	1.5	No	No	0	7	6
438	R:R:L296	R:R:S292	1.5	No	No	0	1	4
439	R:R:L296	R:R:S295	1.5	No	No	0	1	4
440	R:R:L28	R:R:V27	1.49	No	No	0	4	3
441	R:R:L226	R:R:V222	1.49	No	No	0	4	4
442	R:R:N336	R:R:S339	1.49	No	No	0	2	5
443	L:L:L30	L:L:V110	1.49	No	No	0	8	8
444	R:R:N149	R:R:V145	1.48	No	No	0	4	5
445	R:R:D30	R:R:S32	1.47	No	No	0	2	4
446	R:R:K324	R:R:K327	1.44	No	No	0	8	6
447	L:L:F60	L:L:P61	1.44	Yes	No	0	4	4
448	R:R:I187	R:R:N182	1.42	No	No	0	5	1
449	L:L:Q134	L:L:T133	1.42	No	No	0	6	4
450	R:R:A181	R:R:F190	1.39	No	Yes	0	2	3
451	R:R:A36	R:R:R37	1.38	No	No	0	4	3
452	R:R:P204	R:R:W203	1.35	No	Yes	0	5	7
453	L:L:L72	L:L:Q73	1.33	No	No	0	8	7
454	L:L:E132	L:L:L136	1.33	No	No	0	5	3
455	R:R:R154	R:R:S152	1.32	No	No	0	5	6
456	R:R:D210	R:R:Q208	1.31	No	No	0	4	7
457	R:R:F52	R:R:I55	1.26	No	No	0	5	5
458	R:R:F318	R:R:I64	1.26	Yes	No	5	6	7
459	R:R:F323	R:R:I64	1.26	No	No	5	8	7
460	R:R:I41	R:R:R40	1.25	No	No	0	5	4
461	L:L:H130	L:L:Q131	1.24	No	No	0	4	5
462	R:R:M158	R:R:Y157	1.2	No	Yes	0	3	3
463	R:R:M161	R:R:Y157	1.2	No	Yes	0	4	3
464	L:L:F37	R:R:D23	1.19	Yes	No	0	8	6
465	L:L:F37	L:L:H40	1.13	Yes	No	0	8	8
466	L:L:F148	L:L:R140	1.07	No	No	0	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L22	4.678	5	3	4
2	R:R:Y47	4.13333	6	0	8
3	R:R:N58	5.17	4	0	9
4	R:R:M69	2.614	5	5	5
5	R:R:W77	5.00167	6	0	7
6	R:R:F78	2.96	4	0	8
7	R:R:L81	4.178	5	2	9
8	R:R:D85	5.566	5	2	9
9	R:R:F86	5.07	4	0	8
10	R:R:F88	4.26	4	0	8
11	R:R:N89	3.52	4	0	6
12	R:R:L92	3.845	4	9	8
13	R:R:Y103	6.8525	4	0	4
14	R:R:W105	10.932	5	1	9
15	R:R:F107	6.858	5	1	8
16	R:R:F117	6.566	5	11	5
17	R:R:I120	4.196	5	1	4
18	R:R:H121	4.888	5	7	5
19	R:R:F124	6.1025	4	1	7
20	R:R:T125	6.89	4	7	7
21	R:R:L130	6.335	4	2	8
22	R:R:S134	3.79	4	0	9
23	R:R:Y157	4.3875	4	0	3
24	R:R:W164	6.984	5	7	9
25	R:R:L170	5.27	4	0	5
26	R:R:F177	9.915	4	1	4
27	R:R:R178	6.34	5	1	5
28	R:R:F190	6.805	4	4	3
29	R:R:N191	6.9175	4	1	5
30	R:R:N192	7.955	4	4	2
31	R:R:F193	12.478	5	1	5
32	R:R:S194	3.62	4	0	3
33	R:R:P198	4.135	4	4	4
34	R:R:W203	3.7825	4	0	7
35	R:R:R216	5.05	4	1	4
36	R:R:H217	8.065	4	1	4
37	R:R:V220	5.695	4	1	5
38	R:R:R224	6.512	5	1	5
39	R:R:F229	3.80167	6	2	9
40	R:R:P232	3.3625	4	0	9
41	R:R:Y240	6.798	5	12	9
42	R:R:I265	4.406	5	0	8
43	R:R:F269	4.456	5	2	9
44	R:R:W273	5.54143	7	2	9
45	R:R:E283	4.292	5	0	4
46	R:R:F294	5.0325	4	0	5
47	R:R:I306	3.6425	4	9	7
48	R:R:N308	4.712	5	2	9
49	R:R:N312	7.5075	4	2	9
50	R:R:Y316	5.5125	4	0	9
51	R:R:V317	3.62	4	5	7
52	R:R:F318	7.02	6	5	6
53	L:L:R27	11.1	4	14	4
54	L:L:F37	5.15	5	3	8
55	L:L:F60	4.724	5	6	4
56	L:L:F65	4.47	5	6	8
57	L:L:V66	4.716	5	8	9
58	L:L:K71	8.314	5	14	4
59	L:L:W82	10.05	5	0	5
60	L:L:R96	4.76333	6	3	7
61	L:L:K97	6.425	4	3	4
62	L:L:C98	4.625	4	3	8
63	L:L:I102	3.8975	4	0	5
64	L:L:L104	6.1725	4	8	9
65	L:L:R113	7.70333	6	3	7
66	L:L:C117	3.78	4	3	9
67	L:L:I119	7.95	4	3	4
68	L:L:Q139	12.5225	4	6	5
69	L:L:Y149	5.014	5	4	5
70	L:L:F150	6.93	5	4	4
71	L:L:Q153	7.315	4	4	6
72	L:L:F154	7.095	4	4	6
73	L:L:F156	5.402	5	9	9
74	L:L:S157	4.5275	4	1	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F37	R:R:L22	23.2131	6.09	Yes	Yes	3	8	4
2	L:L:F37	L:L:R113	25.2945	8.55	Yes	Yes	3	8	7
3	L:L:R113	R:R:V27	14.9891	18.31	Yes	No	3	7	3
4	R:R:L28	R:R:V27	14.7431	1.49	No	No	0	4	3
5	R:R:D30	R:R:L28	13.7149	2.71	No	No	0	2	4
6	R:R:D30	R:R:S32	12.6828	1.47	No	No	0	2	4
7	R:R:E35	R:R:S32	10.6071	2.87	No	No	0	3	4
8	L:L:I102	L:L:R113	55.6418	3.76	Yes	Yes	0	5	7
9	L:L:I102	L:L:V66	57.7233	3.07	Yes	Yes	0	5	9
10	L:L:D57	L:L:V66	75.1706	7.3	No	Yes	8	6	9
11	L:L:D57	L:L:P59	85.1146	3.22	No	No	0	6	2
12	L:L:P59	L:L:T58	85.7623	1.75	No	No	0	2	3
13	L:L:F60	L:L:T58	84.4535	3.89	Yes	No	6	4	3
14	L:L:F60	R:R:H184	90.7497	4.53	Yes	No	6	4	2
15	R:R:H184	R:R:L183	99.4292	10.29	No	No	0	2	1
16	L:L:F150	R:R:L183	100	3.65	Yes	No	0	4	1
17	L:L:F150	L:L:Q153	94.9127	8.2	Yes	Yes	4	4	6
18	L:L:Q153	L:L:Y149	88.2378	5.64	Yes	Yes	4	6	5
19	L:L:Y149	R:R:E283	94.3207	5.61	Yes	Yes	0	5	4
20	R:R:E283	R:R:N280	80.0177	3.94	Yes	No	0	4	5
21	R:R:N280	R:R:Y276	80.0235	15.12	No	No	0	5	6
22	L:L:F156	R:R:Y276	27.5547	3.09	Yes	No	0	9	6
23	R:R:W273	R:R:Y276	71.4132	2.89	Yes	No	0	9	6
24	R:R:M123	R:R:W273	38.9018	8.14	No	Yes	0	8	9
25	R:R:F88	R:R:M123	18.3314	3.73	Yes	No	0	8	8
26	R:R:F88	R:R:N89	20.3975	3.62	Yes	Yes	0	8	6
27	L:L:F156	R:R:L119	11.3605	4.87	Yes	No	0	9	6
28	R:R:F88	R:R:L119	11.4489	3.65	Yes	No	0	8	6
29	R:R:N58	R:R:N89	15.4466	4.09	Yes	Yes	0	9	6
30	R:R:F86	R:R:N58	18.6562	3.62	Yes	Yes	0	8	9
31	R:R:N308	R:R:W273	50.4641	10.17	Yes	Yes	2	9	9
32	R:R:N308	R:R:N312	15.1352	5.45	Yes	Yes	2	9	9
33	R:R:L130	R:R:N308	36.7954	2.75	Yes	Yes	2	8	9
34	R:R:L130	R:R:Y316	33.3128	4.69	Yes	Yes	0	8	9
35	R:R:F78	R:R:Y316	26.2209	3.09	Yes	Yes	0	8	9
36	R:R:F78	R:R:V317	23.8934	2.62	Yes	Yes	0	8	7
37	R:R:F318	R:R:V317	11.8064	3.93	Yes	Yes	5	6	7
38	R:R:F86	R:R:I62	13.8437	3.77	Yes	No	0	8	7
39	R:R:I62	R:R:T66	11.1261	1.52	No	No	0	7	4
40	R:R:I133	R:R:W77	12.2139	3.52	No	Yes	0	9	7
41	R:R:L129	R:R:L81	13.3766	4.15	No	Yes	0	8	9
42	R:R:C160	R:R:N80	18.0892	11.02	No	No	0	7	9
43	R:R:C160	R:R:V76	14.1723	3.42	No	No	0	7	6
44	L:L:G152	R:R:E283	24.322	3.27	No	Yes	0	9	4
45	L:L:G152	R:R:N191	24.0241	5.09	No	Yes	0	9	5
46	L:L:S157	R:R:N191	22.8056	4.47	Yes	Yes	1	5	5
47	L:L:S157	R:R:I120	34.0854	3.1	Yes	Yes	1	5	4
48	R:R:I120	R:R:S171	20.9971	6.19	Yes	No	0	4	7
49	R:R:H121	R:R:S171	16.0385	4.18	Yes	No	0	5	7
50	R:R:H121	R:R:W164	11.8775	8.46	Yes	Yes	7	5	9
51	R:R:N80	R:R:W164	10.2016	5.65	No	Yes	0	9	9
52	R:R:V76	R:R:Y157	13.344	11.36	No	Yes	0	6	3
53	L:L:F154	L:L:Q153	10.2727	8.2	Yes	Yes	4	6	6
54	L:L:F154	R:R:Y103	13.6899	11.35	Yes	Yes	0	6	4
55	R:R:Y103	R:R:Y98	11.5604	7.94	Yes	No	0	4	5
56	R:R:W105	R:R:Y98	11.3605	10.61	Yes	No	0	9	5
57	R:R:F107	R:R:W105	20.8126	19.04	Yes	Yes	1	8	9
58	R:R:F107	R:R:V106	16.3883	3.93	Yes	No	0	8	3
59	R:R:H104	R:R:V106	14.3933	2.77	No	No	0	5	3
60	R:R:H104	R:R:K186	10.3573	3.93	No	No	0	5	2
61	R:R:C189	R:R:W105	15.8559	3.92	No	Yes	1	9	9
62	R:R:F269	R:R:W273	27.7315	8.02	Yes	Yes	2	9	9
63	R:R:F269	R:R:I236	24.8141	2.51	Yes	No	0	9	8
64	R:R:I236	R:R:S134	24.2701	4.64	No	Yes	0	8	9
65	R:R:C239	R:R:S134	23.338	3.44	No	Yes	0	7	9
66	R:R:S134	R:R:Y240	13.1076	3.82	Yes	Yes	0	9	9
67	R:R:C138	R:R:C239	22.3175	7.28	No	No	0	8	7
68	R:R:C138	R:R:I243	11.9006	3.27	No	No	0	8	8
69	R:R:I243	R:R:V141	10.8378	6.14	No	No	0	8	8
70	R:R:F177	R:R:R216	10.0901	4.28	Yes	Yes	1	4	4
71	L:L:F150	R:R:W203	14.13	3.01	Yes	Yes	0	4	7
72	R:R:S194	R:R:V212	13.1614	3.23	Yes	No	0	3	3
73	R:R:R216	R:R:V212	21.983	7.85	Yes	No	0	4	3
74	R:R:F193	R:R:R216	21.6294	3.21	Yes	Yes	1	5	4
75	R:R:F193	R:R:V220	11.8045	6.55	Yes	Yes	1	5	5
76	R:R:F193	R:R:N191	15.091	12.08	Yes	Yes	1	5	5
77	R:R:P211	R:R:V212	12.5598	3.53	No	No	0	2	3
78	R:R:D210	R:R:P211	11.0031	4.83	No	No	0	4	2
79	R:R:F229	R:R:W273	18.366	2	Yes	Yes	2	9	9
80	L:L:Q26	L:L:R27	10.9704	4.67	No	Yes	0	8	4
81	L:L:Q26	L:L:V66	12.9154	7.16	No	Yes	0	8	9
82	L:L:E36	L:L:W82	14.0436	2.18	No	Yes	0	5	5
83	L:L:E36	L:L:R113	14.993	10.47	No	Yes	0	5	7
84	L:L:G105	L:L:G63	11.818	2.11	No	No	0	5	9
85	L:L:G105	L:L:L104	13.7745	3.42	No	Yes	0	5	9
86	L:L:R96	R:R:L22	13.2152	7.29	Yes	Yes	3	7	4
87	R:R:I120	R:R:M123	38.9191	2.92	Yes	No	0	4	8
88	R:R:C189	R:R:R178	16.7919	6.96	No	Yes	1	9	5
89	L:L:S157	R:R:R178	15.2986	6.59	Yes	Yes	1	5	5
90	R:R:I120	R:R:R224	18.1469	6.26	Yes	Yes	1	4	5
91	R:R:R224	R:R:V220	18.0527	6.54	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D20	R:R:L22	4.07	3	No	Yes	3	4	1	1
L:L:C77	R:R:D20	6.22	0	No	No	9	3	0	1
L:L:R96	R:R:D20	10.72	3	Yes	No	7	3	0	1
L:L:I119	R:R:Y21	16.92	3	Yes	No	4	7	0	1
L:L:L34	R:R:L22	2.77	0	No	Yes	8	4	0	1
L:L:F37	R:R:L22	6.09	3	Yes	Yes	8	4	0	1
L:L:R96	R:R:L22	7.29	3	Yes	Yes	7	4	0	1
L:L:C117	R:R:L22	3.17	3	Yes	Yes	9	4	0	1
L:L:L114	R:R:S24	3	0	No	No	7	4	0	1
L:L:H116	R:R:S24	9.76	0	No	No	8	4	0	1
R:R:I25	R:R:V27	3.07	3	No	No	5	3	1	1
L:L:F37	R:R:I25	8.79	3	Yes	No	8	5	0	1
L:L:R113	R:R:I25	2.51	3	Yes	No	7	5	0	1
L:L:R113	R:R:V27	18.31	3	Yes	No	7	3	0	1
R:R:I96	R:R:Y47	3.63	0	No	Yes	7	8	2	2
R:R:T302	R:R:Y47	4.99	0	No	Yes	6	8	1	2
R:R:I306	R:R:Y47	3.63	9	Yes	Yes	7	8	1	2
R:R:I306	R:R:V50	3.07	9	Yes	No	7	7	1	2
R:R:C51	R:R:L92	3.17	0	No	Yes	6	8	2	1
R:R:F88	R:R:L119	3.65	0	Yes	No	8	6	2	1
R:R:F88	R:R:M123	3.73	0	Yes	No	8	8	2	2
R:R:I96	R:R:L92	5.71	0	No	Yes	7	8	2	1
R:R:I306	R:R:L92	2.85	9	Yes	Yes	7	8	1	1
L:L:F156	R:R:L92	3.65	9	Yes	Yes	9	8	0	1
R:R:Y103	R:R:Y98	7.94	0	Yes	No	4	5	1	2
R:R:A99	R:R:Y103	5.34	0	No	Yes	5	4	2	1
R:R:P299	R:R:Y103	2.78	0	No	Yes	3	4	2	1
L:L:F154	R:R:Y103	11.35	4	Yes	Yes	6	4	0	1
R:R:H104	R:R:K186	3.93	0	No	No	5	2	2	1
R:R:K113	R:R:R178	2.48	0	No	Yes	7	5	2	1
R:R:N116	R:R:R178	9.64	0	No	Yes	6	5	2	1
L:L:F156	R:R:L119	4.87	9	Yes	No	9	6	0	1
R:R:I120	R:R:M123	2.92	1	Yes	No	4	8	1	2
R:R:F124	R:R:I120	2.51	1	Yes	Yes	7	4	2	1
R:R:I120	R:R:S171	6.19	1	Yes	No	4	7	1	2
R:R:I120	R:R:R224	6.26	1	Yes	Yes	4	5	1	1
L:L:S157	R:R:I120	3.1	1	Yes	Yes	5	4	0	1
R:R:M123	R:R:W273	8.14	0	No	Yes	8	9	2	2
R:R:F124	R:R:R224	4.28	1	Yes	Yes	7	5	2	1
R:R:P173	R:R:V220	7.07	1	No	Yes	8	5	2	2
R:R:P173	R:R:R224	11.53	1	No	Yes	8	5	2	1
R:R:C189	R:R:R178	6.96	1	No	Yes	9	5	2	1
R:R:N191	R:R:R178	6.03	1	Yes	Yes	5	5	1	1
L:L:S157	R:R:R178	6.59	1	Yes	Yes	5	5	0	1
R:R:H184	R:R:L183	10.29	6	No	No	2	1	1	1
L:L:F150	R:R:L183	3.65	4	Yes	No	4	1	0	1
L:L:F60	R:R:H184	4.53	6	Yes	No	4	2	0	1
L:L:Q139	R:R:H184	27.2	6	Yes	No	5	2	0	1
L:L:R137	R:R:K186	13.61	10	No	No	5	2	0	1
L:L:R140	R:R:K186	8.66	10	No	No	4	2	0	1
R:R:F190	R:R:S188	2.64	4	Yes	No	3	4	1	1
L:L:F150	R:R:S188	2.64	4	Yes	No	4	4	0	1
L:L:Q153	R:R:S188	7.22	4	Yes	No	6	4	0	1
R:R:F190	R:R:N192	6.04	4	Yes	Yes	3	2	1	2
L:L:F150	R:R:F190	17.15	4	Yes	Yes	4	3	0	1
R:R:F193	R:R:N191	12.08	1	Yes	Yes	5	5	2	1
L:L:G152	R:R:N191	5.09	0	No	Yes	9	5	0	1
L:L:S157	R:R:N191	4.47	1	Yes	Yes	5	5	0	1
R:R:F193	R:R:H217	16.97	1	Yes	Yes	5	4	2	1
R:R:F193	R:R:V220	6.55	1	Yes	Yes	5	5	2	2
R:R:T205	R:R:W203	7.28	0	No	Yes	5	7	1	1
R:R:M209	R:R:W203	3.49	0	No	Yes	5	7	2	1
L:L:F150	R:R:W203	3.01	4	Yes	Yes	4	7	0	1
R:R:H217	R:R:T221	6.85	1	Yes	No	4	6	1	2
R:R:H217	R:R:L284	3.86	1	Yes	No	4	5	1	2
L:L:P151	R:R:H217	4.58	0	No	Yes	9	4	0	1
R:R:R224	R:R:V220	6.54	1	Yes	Yes	5	5	1	2
R:R:L284	R:R:T221	7.37	1	No	No	5	6	2	2
L:L:S157	R:R:R224	3.95	1	Yes	Yes	5	5	0	1
R:R:W273	R:R:Y276	2.89	2	Yes	No	9	6	2	1
R:R:N280	R:R:Y276	15.12	0	No	No	5	6	2	1
L:L:F156	R:R:Y276	3.09	9	Yes	No	9	6	0	1
R:R:L279	R:R:L298	5.54	0	No	No	4	4	2	1
R:R:E283	R:R:N280	3.94	0	Yes	No	4	5	1	2
R:R:E283	R:R:F294	4.66	0	Yes	Yes	4	5	1	1
R:R:E283	R:R:L298	3.98	0	Yes	No	4	4	1	1
L:L:Y149	R:R:E283	5.61	4	Yes	Yes	5	4	0	1
L:L:G152	R:R:E283	3.27	0	No	Yes	9	4	0	1
L:L:Y149	R:R:H286	4.36	4	Yes	No	5	2	0	1
R:R:F294	R:R:M289	2.49	0	Yes	No	5	3	1	2
L:L:H146	R:R:G291	7.94	0	No	No	5	2	0	1
R:R:F294	R:R:V293	3.93	0	Yes	No	5	1	1	2
L:L:H146	R:R:F294	9.05	0	No	Yes	5	5	0	1
L:L:F154	R:R:S295	2.64	4	Yes	No	6	4	0	1
L:L:F156	R:R:T302	10.38	9	Yes	No	9	6	0	1
L:L:F156	R:R:I306	5.02	9	Yes	Yes	9	7	0	1
L:L:T133	R:R:G185	1.82	0	No	No	4	6	0	1
L:L:S147	R:R:T205	1.6	0	No	No	3	5	0	1
L:L:A155	R:R:L298	1.58	0	No	No	9	4	0	1
R:R:L296	R:R:S295	1.5	0	No	No	1	4	2	1
R:R:L28	R:R:V27	1.49	0	No	No	4	3	2	1
R:R:A181	R:R:F190	1.39	0	No	Yes	2	3	2	1
R:R:P204	R:R:W203	1.35	0	No	Yes	5	7	2	1
L:L:F37	R:R:D23	1.19	3	Yes	No	8	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZJG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	402
Number of Links	466
Number of Hubs	74
Number of Links mediated by Hubs	260
Number of Communities	14
Number of Nodes involved in Communities	94
Number of Links involved in Communities	126

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	131109
Length Of Smallest Path	3
Average Path Length	15.7844
Length of Longest Path	43
Minimum Path Strength	1.16
Average Path Strength	5.50905
Maximum Path Strength	20.275
Minimum Path Correlation	0.71
Average Path Correlation	0.959553
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	61.6955
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.5561
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• humoral immune response • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • developmental process • cellular developmental process • cell differentiation • cellular process • chemotaxis • positive regulation of locomotion • regulation of biological process • regulation of response to external stimulus • biological regulation • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • response to activity • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • innate immune response • lipid catabolic process • catabolic process • regulation of cellular process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • cellular response to stimulus • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle • organelle lumen • platelet dense granule • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • cell periphery • extracellular matrix • external encapsulating structure • extracellular region • extracellular space • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • adipokinetic hormone binding • peptide hormone binding • hormone binding • molecular transducer activity • signaling receptor activity • protein-hormone receptor activity • adipokinetic hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled chemoattractant receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • complement receptor activity • positive regulation of cytosolic calcium ion concentration • immune response • skeletal system development • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • immune response-activating cell surface receptor signaling pathway • regulation of response to stimulus • regulation of immune response • activation of immune response • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • regulation of mononuclear cell migration • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • locomotion • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • granulocyte chemotaxis • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of signal transduction • regulation of intracellular signal transduction • calcium-mediated signaling • regulation of calcium-mediated signaling • defense response • response to stress • inflammatory response • regulation of interleukin-12 production • negative regulation of interleukin-12 production • cytokine production • regulation of cytokine production • interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99788
Sequence	>8ZJG_nogp_Chain_R D Y L D S I V V L E D L S P L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K M K K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D Y H W V F G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L P V W S Q N H R S V R L A Y M A C M V I W V L A F F L S S P S L V F R D T A N L H G K I S C F N N F S L S T P G S S S W P T H S Q M D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R L A K T K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H T A M P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D F K K F K V A L F S R L V N A L S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Chemerin
UniProt	Q99969
Sequence	>8ZJG_nogp_Chain_L E L T E A Q R R G L Q V A L E E F H K H S A V D T P F P A G I F V R L E F K L Q Q T S C R K R D W K K P R K C L A C I K L G S E D K V L G R L V H C P I E H Q E T Q C L R V Q R A G E D P H S F Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YKD	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	7YKD (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	8SG1	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8SG1 (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8ZJG	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	8ZJG (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	9L3W	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3W (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Z	A	Protein	Chemerin	CML1	Homo sapiens	LRH7-C2	-	-	3.9	2025-03-12	doi.org/10.1093/procel/pwae073

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