Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L22 4.678534
2R:R:Y47 4.13333608
3R:R:N58 5.17409
4R:R:M69 2.614555
5R:R:W77 5.00167607
6R:R:F78 2.96408
7R:R:L81 4.178529
8R:R:D85 5.566529
9R:R:F86 5.07408
10R:R:F88 4.26408
11R:R:N89 3.52406
12R:R:L92 3.845498
13R:R:Y103 6.8525404
14R:R:W105 10.932519
15R:R:F107 6.858518
16R:R:F117 6.5665115
17R:R:I120 4.196514
18R:R:H121 4.888575
19R:R:F124 6.1025417
20R:R:T125 6.89477
21R:R:L130 6.335428
22R:R:S134 3.79409
23R:R:Y157 4.3875403
24R:R:W164 6.984579
25R:R:L170 5.27405
26R:R:F177 9.915414
27R:R:R178 6.34515
28R:R:F190 6.805443
29R:R:N191 6.9175415
30R:R:N192 7.955442
31R:R:F193 12.478515
32R:R:S194 3.62403
33R:R:P198 4.135444
34R:R:W203 3.7825407
35R:R:R216 5.05414
36R:R:H217 8.065414
37R:R:V220 5.695415
38R:R:R224 6.512515
39R:R:F229 3.80167629
40R:R:P232 3.3625409
41R:R:Y240 6.7985129
42R:R:I265 4.406508
43R:R:F269 4.456529
44R:R:W273 5.54143729
45R:R:E283 4.292504
46R:R:F294 5.0325405
47R:R:I306 3.6425497
48R:R:N308 4.712529
49R:R:N312 7.5075429
50R:R:Y316 5.5125409
51R:R:V317 3.62457
52R:R:F318 7.02656
53L:L:R7 11.14140
54L:L:F17 5.15530
55L:L:F40 4.724560
56L:L:F45 4.47560
57L:L:V46 4.716580
58L:L:K51 8.3145140
59L:L:W62 10.05500
60L:L:R76 4.76333630
61L:L:K77 6.425430
62L:L:C78 4.625430
63L:L:I82 3.8975400
64L:L:L84 6.1725480
65L:L:R93 7.70333630
66L:L:C97 3.78430
67L:L:I99 7.95430
68L:L:Q119 12.5225460
69L:L:Y129 5.014540
70L:L:F130 6.93540
71L:L:Q133 7.315440
72L:L:F134 7.095440
73L:L:F136 5.402590
74L:L:S137 4.5275410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:F17 R:R:L22 23.21316.09YesYes304
2L:L:F17 L:L:R93 25.29458.55YesYes300
3L:L:R93 R:R:V27 14.989118.31YesNo303
4R:R:L28 R:R:V27 14.74311.49NoNo043
5R:R:D30 R:R:L28 13.71492.71NoNo024
6R:R:D30 R:R:S32 12.68281.47NoNo024
7R:R:E35 R:R:S32 10.60712.87NoNo034
8L:L:I82 L:L:R93 55.64183.76YesYes000
9L:L:I82 L:L:V46 57.72333.07YesYes000
10L:L:D37 L:L:V46 75.17067.3NoYes800
11L:L:D37 L:L:P39 85.11463.22NoNo000
12L:L:P39 L:L:T38 85.76231.75NoNo000
13L:L:F40 L:L:T38 84.45353.89YesNo600
14L:L:F40 R:R:H184 90.74974.53YesNo602
15R:R:H184 R:R:L183 99.429210.29NoNo021
16L:L:F130 R:R:L183 1003.65YesNo001
17L:L:F130 L:L:Q133 94.91278.2YesYes400
18L:L:Q133 L:L:Y129 88.23785.64YesYes400
19L:L:Y129 R:R:E283 94.32075.61YesYes004
20R:R:E283 R:R:N280 80.01773.94YesNo045
21R:R:N280 R:R:Y276 80.023515.12NoNo056
22L:L:F136 R:R:Y276 27.55473.09YesNo006
23R:R:W273 R:R:Y276 71.41322.89YesNo096
24R:R:M123 R:R:W273 38.90188.14NoYes089
25R:R:F88 R:R:M123 18.33143.73YesNo088
26R:R:F88 R:R:N89 20.39753.62YesYes086
27L:L:F136 R:R:L119 11.36054.87YesNo006
28R:R:F88 R:R:L119 11.44893.65YesNo086
29R:R:N58 R:R:N89 15.44664.09YesYes096
30R:R:F86 R:R:N58 18.65623.62YesYes089
31R:R:N308 R:R:W273 50.464110.17YesYes299
32R:R:N308 R:R:N312 15.13525.45YesYes299
33R:R:L130 R:R:N308 36.79542.75YesYes289
34R:R:L130 R:R:Y316 33.31284.69YesYes089
35R:R:F78 R:R:Y316 26.22093.09YesYes089
36R:R:F78 R:R:V317 23.89342.62YesYes087
37R:R:F318 R:R:V317 11.80643.93YesYes567
38R:R:F86 R:R:I62 13.84373.77YesNo087
39R:R:I62 R:R:T66 11.12611.52NoNo074
40R:R:I133 R:R:W77 12.21393.52NoYes097
41R:R:L129 R:R:L81 13.37664.15NoYes089
42R:R:C160 R:R:N80 18.089211.02NoNo079
43R:R:C160 R:R:V76 14.17233.42NoNo076
44L:L:G132 R:R:E283 24.3223.27NoYes004
45L:L:G132 R:R:N191 24.02415.09NoYes005
46L:L:S137 R:R:N191 22.80564.47YesYes105
47L:L:S137 R:R:I120 34.08543.1YesYes104
48R:R:I120 R:R:S171 20.99716.19YesNo047
49R:R:H121 R:R:S171 16.03854.18YesNo057
50R:R:H121 R:R:W164 11.87758.46YesYes759
51R:R:N80 R:R:W164 10.20165.65NoYes099
52R:R:V76 R:R:Y157 13.34411.36NoYes063
53L:L:F134 L:L:Q133 10.27278.2YesYes400
54L:L:F134 R:R:Y103 13.689911.35YesYes004
55R:R:Y103 R:R:Y98 11.56047.94YesNo045
56R:R:W105 R:R:Y98 11.360510.61YesNo095
57R:R:F107 R:R:W105 20.812619.04YesYes189
58R:R:F107 R:R:V106 16.38833.93YesNo083
59R:R:H104 R:R:V106 14.39332.77NoNo053
60R:R:H104 R:R:K186 10.35733.93NoNo052
61R:R:C189 R:R:W105 15.85593.92NoYes199
62R:R:F269 R:R:W273 27.73158.02YesYes299
63R:R:F269 R:R:I236 24.81412.51YesNo098
64R:R:I236 R:R:S134 24.27014.64NoYes089
65R:R:C239 R:R:S134 23.3383.44NoYes079
66R:R:S134 R:R:Y240 13.10763.82YesYes099
67R:R:C138 R:R:C239 22.31757.28NoNo087
68R:R:C138 R:R:I243 11.90063.27NoNo088
69R:R:I243 R:R:V141 10.83786.14NoNo088
70R:R:F177 R:R:R216 10.09014.28YesYes144
71L:L:F130 R:R:W203 14.133.01YesYes007
72R:R:S194 R:R:V212 13.16143.23YesNo033
73R:R:R216 R:R:V212 21.9837.85YesNo043
74R:R:F193 R:R:R216 21.62943.21YesYes154
75R:R:F193 R:R:V220 11.80456.55YesYes155
76R:R:F193 R:R:N191 15.09112.08YesYes155
77R:R:P211 R:R:V212 12.55983.53NoNo023
78R:R:D210 R:R:P211 11.00314.83NoNo042
79R:R:F229 R:R:W273 18.3662YesYes299
80L:L:Q6 L:L:R7 10.97044.67NoYes000
81L:L:Q6 L:L:V46 12.91547.16NoYes000
82L:L:E16 L:L:W62 14.04362.18NoYes000
83L:L:E16 L:L:R93 14.99310.47NoYes000
84L:L:G43 L:L:G85 11.8182.11NoNo000
85L:L:G85 L:L:L84 13.77453.42NoYes000
86L:L:R76 R:R:L22 13.21527.29YesYes304
87R:R:I120 R:R:M123 38.91912.92YesNo048
88R:R:C189 R:R:R178 16.79196.96NoYes195
89L:L:S137 R:R:R178 15.29866.59YesYes105
90R:R:I120 R:R:R224 18.14696.26YesYes145
91R:R:R224 R:R:V220 18.05276.54YesYes155
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D20 R:R:L22 4.07 3 No Yes 3 4 1 1
L:L:C57 R:R:D20 6.22 0 No No 0 3 0 1
L:L:R76 R:R:D20 10.72 3 Yes No 0 3 0 1
L:L:I99 R:R:Y21 16.92 3 Yes No 0 7 0 1
L:L:L14 R:R:L22 2.77 0 No Yes 0 4 0 1
L:L:F17 R:R:L22 6.09 3 Yes Yes 0 4 0 1
L:L:R76 R:R:L22 7.29 3 Yes Yes 0 4 0 1
L:L:C97 R:R:L22 3.17 3 Yes Yes 0 4 0 1
L:L:L94 R:R:S24 3 0 No No 0 4 0 1
L:L:H96 R:R:S24 9.76 0 No No 0 4 0 1
R:R:I25 R:R:V27 3.07 3 No No 5 3 1 1
L:L:F17 R:R:I25 8.79 3 Yes No 0 5 0 1
L:L:R93 R:R:I25 2.51 3 Yes No 0 5 0 1
L:L:R93 R:R:V27 18.31 3 Yes No 0 3 0 1
R:R:I96 R:R:Y47 3.63 0 No Yes 7 8 2 2
R:R:T302 R:R:Y47 4.99 0 No Yes 6 8 1 2
R:R:I306 R:R:Y47 3.63 9 Yes Yes 7 8 1 2
R:R:I306 R:R:V50 3.07 9 Yes No 7 7 1 2
R:R:C51 R:R:L92 3.17 0 No Yes 6 8 2 1
R:R:F88 R:R:L119 3.65 0 Yes No 8 6 2 1
R:R:F88 R:R:M123 3.73 0 Yes No 8 8 2 2
R:R:I96 R:R:L92 5.71 0 No Yes 7 8 2 1
R:R:I306 R:R:L92 2.85 9 Yes Yes 7 8 1 1
L:L:F136 R:R:L92 3.65 9 Yes Yes 0 8 0 1
R:R:Y103 R:R:Y98 7.94 0 Yes No 4 5 1 2
R:R:A99 R:R:Y103 5.34 0 No Yes 5 4 2 1
R:R:P299 R:R:Y103 2.78 0 No Yes 3 4 2 1
L:L:F134 R:R:Y103 11.35 4 Yes Yes 0 4 0 1
R:R:H104 R:R:K186 3.93 0 No No 5 2 2 1
R:R:K113 R:R:R178 2.48 0 No Yes 7 5 2 1
R:R:N116 R:R:R178 9.64 0 No Yes 6 5 2 1
L:L:F136 R:R:L119 4.87 9 Yes No 0 6 0 1
R:R:I120 R:R:M123 2.92 1 Yes No 4 8 1 2
R:R:F124 R:R:I120 2.51 1 Yes Yes 7 4 2 1
R:R:I120 R:R:S171 6.19 1 Yes No 4 7 1 2
R:R:I120 R:R:R224 6.26 1 Yes Yes 4 5 1 1
L:L:S137 R:R:I120 3.1 1 Yes Yes 0 4 0 1
R:R:M123 R:R:W273 8.14 0 No Yes 8 9 2 2
R:R:F124 R:R:R224 4.28 1 Yes Yes 7 5 2 1
R:R:P173 R:R:V220 7.07 1 No Yes 8 5 2 2
R:R:P173 R:R:R224 11.53 1 No Yes 8 5 2 1
R:R:C189 R:R:R178 6.96 1 No Yes 9 5 2 1
R:R:N191 R:R:R178 6.03 1 Yes Yes 5 5 1 1
L:L:S137 R:R:R178 6.59 1 Yes Yes 0 5 0 1
R:R:H184 R:R:L183 10.29 6 No No 2 1 1 1
L:L:F130 R:R:L183 3.65 4 Yes No 0 1 0 1
L:L:F40 R:R:H184 4.53 6 Yes No 0 2 0 1
L:L:Q119 R:R:H184 27.2 6 Yes No 0 2 0 1
L:L:R117 R:R:K186 13.61 10 No No 0 2 0 1
L:L:R120 R:R:K186 8.66 10 No No 0 2 0 1
R:R:F190 R:R:S188 2.64 4 Yes No 3 4 1 1
L:L:F130 R:R:S188 2.64 4 Yes No 0 4 0 1
L:L:Q133 R:R:S188 7.22 4 Yes No 0 4 0 1
R:R:F190 R:R:N192 6.04 4 Yes Yes 3 2 1 2
L:L:F130 R:R:F190 17.15 4 Yes Yes 0 3 0 1
R:R:F193 R:R:N191 12.08 1 Yes Yes 5 5 2 1
L:L:G132 R:R:N191 5.09 0 No Yes 0 5 0 1
L:L:S137 R:R:N191 4.47 1 Yes Yes 0 5 0 1
R:R:F193 R:R:H217 16.97 1 Yes Yes 5 4 2 1
R:R:F193 R:R:V220 6.55 1 Yes Yes 5 5 2 2
R:R:T205 R:R:W203 7.28 0 No Yes 5 7 1 1
R:R:M209 R:R:W203 3.49 0 No Yes 5 7 2 1
L:L:F130 R:R:W203 3.01 4 Yes Yes 0 7 0 1
R:R:H217 R:R:T221 6.85 1 Yes No 4 6 1 2
R:R:H217 R:R:L284 3.86 1 Yes No 4 5 1 2
L:L:P131 R:R:H217 4.58 0 No Yes 0 4 0 1
R:R:R224 R:R:V220 6.54 1 Yes Yes 5 5 1 2
R:R:L284 R:R:T221 7.37 1 No No 5 6 2 2
L:L:S137 R:R:R224 3.95 1 Yes Yes 0 5 0 1
R:R:W273 R:R:Y276 2.89 2 Yes No 9 6 2 1
R:R:N280 R:R:Y276 15.12 0 No No 5 6 2 1
L:L:F136 R:R:Y276 3.09 9 Yes No 0 6 0 1
R:R:L279 R:R:L298 5.54 0 No No 4 4 2 1
R:R:E283 R:R:N280 3.94 0 Yes No 4 5 1 2
R:R:E283 R:R:F294 4.66 0 Yes Yes 4 5 1 1
R:R:E283 R:R:L298 3.98 0 Yes No 4 4 1 1
L:L:Y129 R:R:E283 5.61 4 Yes Yes 0 4 0 1
L:L:G132 R:R:E283 3.27 0 No Yes 0 4 0 1
L:L:Y129 R:R:H286 4.36 4 Yes No 0 2 0 1
R:R:F294 R:R:M289 2.49 0 Yes No 5 3 1 2
L:L:H126 R:R:G291 7.94 0 No No 0 2 0 1
R:R:F294 R:R:V293 3.93 0 Yes No 5 1 1 2
L:L:H126 R:R:F294 9.05 0 No Yes 0 5 0 1
L:L:F134 R:R:S295 2.64 4 Yes No 0 4 0 1
L:L:F136 R:R:T302 10.38 9 Yes No 0 6 0 1
L:L:F136 R:R:I306 5.02 9 Yes Yes 0 7 0 1
L:L:T113 R:R:G185 1.82 0 No No 0 6 0 1
L:L:S127 R:R:T205 1.6 0 No No 0 5 0 1
L:L:A135 R:R:L298 1.58 0 No No 0 4 0 1
R:R:L296 R:R:S295 1.5 0 No No 1 4 2 1
R:R:L28 R:R:V27 1.49 0 No No 4 3 2 1
R:R:A181 R:R:F190 1.39 0 No Yes 2 3 2 1
R:R:P204 R:R:W203 1.35 0 No Yes 5 7 2 1
L:L:F17 R:R:D23 1.19 3 Yes No 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8ZJG_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.45
Number of Linked Nodes 402
Number of Links 466
Number of Hubs 74
Number of Links mediated by Hubs 260
Number of Communities 14
Number of Nodes involved in Communities 94
Number of Links involved in Communities 126
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 131109
Length Of Smallest Path 3
Average Path Length 15.7844
Length of Longest Path 43
Minimum Path Strength 1.16
Average Path Strength 5.50905
Maximum Path Strength 20.275
Minimum Path Correlation 0.71
Average Path Correlation 0.9597
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 61.7285
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.5561
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• amide binding   • binding   • adipokinetic hormone binding   • peptide hormone binding   • hormone binding   • molecular transducer activity   • signaling receptor activity   • protein-hormone receptor activity   • adipokinetic hormone receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • chemokine receptor activity   • cytokine receptor activity   • immune receptor activity   • complement receptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • response to stimulus   • immune response   • immune system process   • developmental process   • multicellular organism development   • multicellular organismal process   • skeletal system development   • anatomical structure development   • system development   • cellular response to stimulus   • immune response-regulating cell surface receptor signaling pathway
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • response to stimulus   • immune response   • immune system process   • developmental process   • multicellular organism development   • multicellular organismal process   • skeletal system development   • anatomical structure development   • system development   • cellular response to stimulus   • immune response-regulating cell surface receptor signaling pathway   • regulation of cellular process   • complement receptor mediated signaling pathway   • signaling   • positive regulation of biological process   • cell communication   • positive regulation of response to stimulus   • immune response-activating signaling pathway   • immune response-regulating signaling pathway   • positive regulation of immune response   • regulation of immune system process   • signal transduction   • positive regulation of immune system process   • regulation of biological process   • cell surface receptor signaling pathway   • immune response-activating cell surface receptor signaling pathway   • regulation of response to stimulus   • regulation of immune response   • cellular process   • activation of immune response   • negative regulation of DNA-binding transcription factor activity   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • negative regulation of NF-kappaB transcription factor activity   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • negative regulation of molecular function   • primary metabolic process   • regulation of macromolecule metabolic process   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of molecular function   • regulation of gene expression   • biosynthetic process   • regulation of DNA-binding transcription factor activity   • metabolic process   • regulation of macromolecule biosynthetic process   • regulation of DNA-templated transcription   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of locomotion   • regulation of cell motility   • macrophage migration   • positive regulation of chemotaxis   • positive regulation of cell migration   • taxis   • cell migration   • regulation of mononuclear cell migration   • chemotaxis   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of macrophage migration   • response to external stimulus   • positive regulation of leukocyte chemotaxis   • granulocyte migration   • leukocyte migration   • response to chemical   • regulation of locomotion   • regulation of response to external stimulus   • macrophage chemotaxis   • regulation of granulocyte chemotaxis   • regulation of macrophage migration   • positive regulation of response to external stimulus   • positive regulation of cell motility   • regulation of cell migration   • myeloid leukocyte migration   • positive regulation of mononuclear cell migration   • cell motility   • locomotion   • positive regulation of cellular process   • cell chemotaxis   • regulation of macrophage chemotaxis   • positive regulation of leukocyte migration   • regulation of chemotaxis   • cellular response to chemical stimulus   • granulocyte chemotaxis   • mononuclear cell migration   • positive regulation of macrophage chemotaxis   • leukocyte chemotaxis   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of signaling   • regulation of signal transduction   • intracellular signal transduction   • regulation of intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • regulation of cell communication   • defense response   • response to stress   • inflammatory response   • negative regulation of biological process   • regulation of interleukin-12 production   • negative regulation of interleukin-12 production   • cytokine production   • negative regulation of cellular process   • regulation of cytokine production   • interleukin-12 production   • negative regulation of macromolecule metabolic process   • negative regulation of metabolic process   • negative regulation of cytokine production   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of multicellular organismal process   • fat cell differentiation   • positive regulation of fat cell differentiation   • regulation of developmental process   • cellular developmental process   • regulation of cell differentiation   • positive regulation of developmental process   • positive regulation of cell differentiation   • cell differentiation   • regulation of fat cell differentiation   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • biological process involved in interspecies interaction between organisms   • antifungal innate immune response   • response to other organism   • defense response to symbiont   • response to biotic stimulus   • defense response to fungus   • defense response to other organism   • innate immune response   • response to external biotic stimulus   • response to fungus   • humoral immune response   • antimicrobial humoral response   • antifungal humoral response   • insulin receptor signaling pathway   • cell surface receptor protein tyrosine kinase signaling pathway   • enzyme-linked receptor protein signaling pathway   • cellular response to peptide hormone stimulus   • response to insulin   • cellular response to insulin stimulus   • defense response to Gram-negative bacterium   • defense response to bacterium   • response to bacterium   • digestive system development   • tube development   • embryo development   • digestive tract development   • embryonic organ development   • embryonic digestive tract development   • positive regulation of phosphorylation   • regulation of protein modification process   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of phosphate metabolic process   • positive regulation of protein modification process   • regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • positive regulation of macromolecule metabolic process   • protein metabolic process   • positive regulation of protein phosphorylation   • phosphorus metabolic process   • protein modification process   • protein phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • regulation of protein metabolic process   • macromolecule modification   • regulation of phosphorus metabolic process   • regulation of phosphorylation   • lipid catabolic process   • catabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • diterpenoid metabolic process   • retinoid metabolic process   • terpenoid metabolic process   • isoprenoid metabolic process   • defense response to Gram-positive bacterium   • vesicle lumen   • intracellular vesicle   • cytoplasmic vesicle lumen   • secretory granule lumen   • platelet dense granule lumen   • cytoplasmic vesicle   • platelet dense granule   • secretory granule   • secretory vesicle   • extracellular matrix   • external encapsulating structure   • collagen-containing extracellular matrix
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ99788
Sequence
>8ZJG_nogp_Chain_R
DYLDSIVVL EDLSPLEAR VTRIFLVVV YSIVCFLGI LGNGLVIII 
ATFKMKKTV NMVWFLNLA VADFLFNVF LPIHITYAA MDYHWVFGT 
AMCKISNFL LIHNMFTSV FLLTIISSD RCISVLLPV WSQNHRSVR 
LAYMACMVI WVLAFFLSS PSLVFRDTA NLHGKISCF NNFSLSTPG 
SSSWPTHSQ MDPVGYSRH MVVTVTRFL CGFLVPVLI ITACYLTIV 
CKLQRNRLA KTKKPFKII VTIIITFFL CWCPYHTLN LLELHHTAM 
PGSVFSLGL PLATALAIA NSCMNPILY VFMGQDFKK FKVALFSRL 
VNALS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9L3ZAProteinChemerinCML1Homo sapiensLRH7-C2--3.92025-03-12doi.org/10.1093/procel/pwae073
9L3WAProteinChemerinCML1Homo sapiensRetinoic acid receptor responder protein 2-Gi1/β1/γ23.52025-03-12doi.org/10.1093/procel/pwae073
9L3W (No Gprot) AProteinChemerinCML1Homo sapiensRetinoic acid receptor responder protein 2-3.52025-03-12doi.org/10.1093/procel/pwae073
8ZJGAProteinChemerinCML1Homo sapiensChemerin-Gi1/β1/γ23.182025-01-22doi.org/10.1038/s42003-024-07228-9
8ZJG (No Gprot) AProteinChemerinCML1Homo sapiensChemerin-3.182025-01-22doi.org/10.1038/s42003-024-07228-9
8SG1AProteinChemerinCML1Homo sapiensChemerin-9-Gi1/β1/γ22.942023-11-0110.1371/journal.pbio.3002188
8SG1 (No Gprot) AProteinChemerinCML1Homo sapiensChemerin-9-2.942023-11-0110.1371/journal.pbio.3002188
7YKDAProteinChemerinCML1Homo sapiensChemerin-9-Gi1/β1/γ22.812023-04-1910.1073/pnas.2214324120
7YKD (No Gprot) AProteinChemerinCML1Homo sapiensChemerin-9-2.812023-04-1910.1073/pnas.2214324120




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