psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q26	L:L:Y22	6.76	No	Yes	3	0	0
2	L:L:F27	L:L:Y22	10.32	Yes	Yes	3	0	0
3	L:L:Y22	R:R:E283	11.22	Yes	Yes	3	0	4
4	L:L:Y22	R:R:H286	14.16	Yes	No	0	0	2
5	L:L:Y22	R:R:F294	12.38	Yes	Yes	3	0	5
6	L:L:F23	R:R:L183	3.65	No	No	0	0	1
7	L:L:F23	R:R:F190	15	No	Yes	0	0	3
8	L:L:F27	L:L:Q26	9.37	Yes	No	3	0	0
9	L:L:Q26	R:R:F190	12.88	No	Yes	0	0	3
10	L:L:F27	R:R:Y103	9.28	Yes	Yes	0	0	4
11	L:L:F29	R:R:L119	7.31	Yes	No	0	0	6
12	L:L:F29	R:R:I120	3.77	Yes	Yes	1	0	4
13	L:L:F29	R:R:M123	6.22	Yes	Yes	1	0	8
14	L:L:F29	R:R:Y276	5.16	Yes	Yes	1	0	6
15	L:L:F29	R:R:T302	3.89	Yes	No	0	0	6
16	L:L:S30	R:R:I120	4.64	Yes	Yes	1	0	4
17	L:L:S30	R:R:S174	6.52	Yes	No	0	0	5
18	L:L:S30	R:R:N191	4.47	Yes	Yes	1	0	5
19	L:L:S30	R:R:R224	9.22	Yes	Yes	1	0	5
20	R:R:R37	R:R:R40	8.53	No	No	0	3	4
21	R:R:D102	R:R:R40	14.29	No	No	0	4	4
22	R:R:F42	R:R:V46	3.93	No	No	0	5	5
23	R:R:L300	R:R:L43	6.92	No	No	0	5	6
24	R:R:I96	R:R:Y47	6.04	No	Yes	0	7	8
25	R:R:T302	R:R:Y47	4.99	No	Yes	0	6	8
26	R:R:A303	R:R:Y47	4	No	Yes	0	5	8
27	R:R:I306	R:R:Y47	4.84	Yes	Yes	0	7	8
28	R:R:I306	R:R:V50	4.61	Yes	No	0	7	7
29	R:R:C51	R:R:L92	4.76	No	Yes	0	6	8
30	R:R:G54	R:R:N89	6.79	No	No	0	8	6
31	R:R:F86	R:R:I55	3.77	No	No	0	8	5
32	R:R:L56	R:R:L60	4.15	No	No	0	5	6
33	R:R:G57	R:R:L60	5.13	No	No	0	7	6
34	R:R:D85	R:R:N58	6.73	Yes	No	0	9	9
35	R:R:N58	R:R:P313	8.15	No	No	0	9	9
36	R:R:G59	R:R:I62	5.29	No	No	0	3	7
37	R:R:F86	R:R:I62	5.02	No	No	0	8	7
38	R:R:I64	R:R:K325	8.72	No	No	0	7	5
39	R:R:A65	R:R:L79	6.3	No	No	0	6	5
40	R:R:F67	R:R:T66	10.38	No	No	0	5	4
41	R:R:K325	R:R:K68	11.49	No	No	0	5	4
42	R:R:M69	R:R:Q321	16.31	No	Yes	0	5	5
43	R:R:K70	R:R:T72	4.5	No	No	0	6	7
44	R:R:K71	R:R:Y157	3.58	No	No	0	6	3
45	R:R:V73	R:R:W77	3.68	No	Yes	0	6	7
46	R:R:R151	R:R:V73	14.38	Yes	No	0	6	6
47	R:R:D136	R:R:N74	5.39	Yes	No	4	8	8
48	R:R:N74	R:R:R151	10.85	No	Yes	4	8	6
49	R:R:M75	R:R:Q321	4.08	No	Yes	0	8	5
50	R:R:A156	R:R:V76	5.09	No	No	0	7	6
51	R:R:V76	R:R:Y157	10.09	No	No	0	6	3
52	R:R:I132	R:R:W77	9.4	No	Yes	0	6	7
53	R:R:I133	R:R:W77	4.7	Yes	Yes	0	9	7
54	R:R:D136	R:R:W77	11.17	Yes	Yes	0	8	7
55	R:R:A156	R:R:W77	5.19	No	Yes	0	7	7
56	R:R:F78	R:R:I133	3.77	No	Yes	2	8	9
57	R:R:F78	R:R:Y316	4.13	No	Yes	2	8	9
58	R:R:F78	R:R:V317	5.24	No	No	0	8	7
59	R:R:C160	R:R:N80	7.87	No	No	0	7	9
60	R:R:D85	R:R:L81	6.79	Yes	Yes	2	9	9
61	R:R:L129	R:R:L81	4.15	No	Yes	0	8	9
62	R:R:L130	R:R:L81	4.15	No	Yes	2	8	9
63	R:R:L81	R:R:N312	10.98	Yes	Yes	2	9	9
64	R:R:D85	R:R:S126	8.83	Yes	No	0	9	9
65	R:R:D85	R:R:N312	10.77	Yes	Yes	2	9	9
66	R:R:F86	R:R:V90	7.87	No	No	0	8	5
67	R:R:L87	R:R:N122	6.87	No	No	0	7	8
68	R:R:F88	R:R:N89	3.62	Yes	No	1	8	6
69	R:R:F88	R:R:L92	3.65	Yes	Yes	1	8	8
70	R:R:F88	R:R:L119	7.31	Yes	No	0	8	6
71	R:R:F88	R:R:N122	6.04	Yes	No	0	8	8
72	R:R:F88	R:R:M123	4.98	Yes	Yes	1	8	8
73	R:R:F88	R:R:I306	5.02	Yes	Yes	1	8	7
74	R:R:F88	R:R:S309	5.28	Yes	No	1	8	9
75	R:R:N89	R:R:S309	4.47	No	No	1	6	9
76	R:R:F91	R:R:V90	3.93	No	No	0	6	5
77	R:R:F91	R:R:L118	9.74	No	No	0	6	5
78	R:R:I96	R:R:L92	7.14	No	Yes	0	7	8
79	R:R:I306	R:R:L92	5.71	Yes	Yes	1	7	8
80	R:R:F107	R:R:I94	3.77	Yes	No	0	8	6
81	R:R:I94	R:R:S115	6.19	No	No	0	6	5
82	R:R:H95	R:R:Y98	4.36	No	Yes	0	6	5
83	R:R:Y103	R:R:Y98	4.96	Yes	Yes	0	4	5
84	R:R:W105	R:R:Y98	10.61	Yes	Yes	0	9	5
85	R:R:S188	R:R:Y98	3.82	No	Yes	0	4	5
86	R:R:A99	R:R:Y103	4	No	Yes	0	5	4
87	R:R:D102	R:R:K186	5.53	No	No	0	4	2
88	R:R:P299	R:R:Y103	4.17	No	Yes	0	3	4
89	R:R:H104	R:R:I187	6.63	No	No	0	5	5
90	R:R:F107	R:R:W105	15.03	Yes	Yes	0	8	9
91	R:R:C112	R:R:W105	13.06	No	Yes	5	9	9
92	R:R:C189	R:R:W105	10.45	No	Yes	5	9	9
93	R:R:F107	R:R:V106	7.87	Yes	No	0	8	3
94	R:R:F107	R:R:M111	6.22	Yes	No	0	8	6
95	R:R:C112	R:R:C189	7.28	No	No	5	9	9
96	R:R:N116	R:R:S115	4.47	No	No	0	6	5
97	R:R:N116	R:R:R178	16.87	No	No	0	6	5
98	R:R:F117	R:R:L118	3.65	No	No	0	5	5
99	R:R:F117	R:R:F168	6.43	No	Yes	0	5	3
100	R:R:F117	R:R:L175	13.4	No	No	0	5	4
101	R:R:I120	R:R:S171	6.19	Yes	No	0	4	7
102	R:R:I120	R:R:R224	6.26	Yes	Yes	1	4	5
103	R:R:H121	R:R:N122	3.83	Yes	No	0	5	8
104	R:R:H121	R:R:T125	5.48	Yes	Yes	6	5	7
105	R:R:H121	R:R:W164	5.29	Yes	No	6	5	9
106	R:R:H121	R:R:S171	5.58	Yes	No	0	5	7
107	R:R:M123	R:R:W273	5.82	Yes	Yes	1	8	9
108	R:R:M123	R:R:Y276	5.99	Yes	Yes	1	8	6
109	R:R:F124	R:R:L170	7.31	No	No	0	7	5
110	R:R:F124	R:R:S171	5.28	No	No	0	7	7
111	R:R:F124	R:R:R224	6.41	No	Yes	0	7	5
112	R:R:T125	R:R:W164	15.77	Yes	No	6	7	9
113	R:R:P232	R:R:V127	3.53	Yes	No	0	9	7
114	R:R:F269	R:R:V127	5.24	Yes	No	1	9	7
115	R:R:V127	R:R:W273	4.9	No	Yes	1	7	9
116	R:R:I163	R:R:L129	5.71	No	No	0	7	8
117	R:R:L130	R:R:N312	4.12	No	Yes	2	8	9
118	R:R:L130	R:R:Y316	7.03	No	Yes	2	8	9
119	R:R:I235	R:R:T131	4.56	No	No	0	7	7
120	R:R:I132	R:R:I163	4.42	No	No	0	6	7
121	R:R:I133	R:R:R137	3.76	Yes	No	2	9	9
122	R:R:I133	R:R:Y316	7.25	Yes	Yes	2	9	9
123	R:R:I236	R:R:S134	7.74	No	No	0	8	9
124	R:R:S134	R:R:Y240	15.26	No	Yes	0	9	9
125	R:R:D136	R:R:S140	4.42	Yes	No	4	8	7
126	R:R:D136	R:R:R151	10.72	Yes	Yes	4	8	6
127	R:R:R137	R:R:Y240	10.29	No	Yes	2	9	9
128	R:R:R137	R:R:Y316	8.23	No	Yes	2	9	9
129	R:R:C138	R:R:C239	7.28	No	No	0	8	7
130	R:R:I139	R:R:L143	4.28	No	No	0	5	6
131	R:R:S140	R:R:S147	4.89	No	No	0	7	4
132	R:R:R151	R:R:S140	5.27	Yes	No	4	6	7
133	R:R:K246	R:R:V141	6.07	Yes	No	0	5	8
134	R:R:L142	R:R:T242	4.42	No	No	0	7	4
135	R:R:K246	R:R:L142	4.23	Yes	No	0	5	7
136	R:R:L143	R:R:W146	5.69	No	No	0	6	4
137	R:R:H150	R:R:W146	19.04	No	No	0	4	4
138	R:R:H150	R:R:N149	3.83	No	No	0	4	4
139	R:R:V153	R:R:Y157	5.05	No	No	0	2	3
140	R:R:M158	R:R:R154	3.72	No	No	0	3	5
141	R:R:F168	R:R:S172	7.93	Yes	No	0	3	4
142	R:R:P173	R:R:V220	5.3	No	Yes	0	8	5
143	R:R:R178	R:R:S174	3.95	No	No	0	5	5
144	R:R:F177	R:R:V176	13.11	Yes	No	0	4	4
145	R:R:F177	R:R:N191	4.83	Yes	Yes	1	4	5
146	R:R:F177	R:R:F193	15	Yes	Yes	1	4	5
147	R:R:F177	R:R:L195	4.87	Yes	No	0	4	4
148	R:R:N191	R:R:R178	8.44	Yes	No	0	5	5
149	R:R:D179	R:R:N192	5.39	No	No	0	4	2
150	R:R:G185	R:R:N182	5.09	No	No	0	6	1
151	R:R:I187	R:R:N182	7.08	No	No	0	5	1
152	R:R:H184	R:R:L183	6.43	No	No	0	2	1
153	R:R:H184	R:R:K186	10.48	No	No	0	2	2
154	R:R:F190	R:R:S188	9.25	Yes	No	0	3	4
155	R:R:F193	R:R:N191	12.08	Yes	Yes	1	5	5
156	R:R:N192	R:R:S196	7.45	No	No	0	2	2
157	R:R:F193	R:R:H217	18.1	Yes	No	0	5	4
158	R:R:F193	R:R:V220	7.87	Yes	Yes	0	5	5
159	R:R:D210	R:R:S194	5.89	Yes	No	0	4	3
160	R:R:D210	R:R:P211	4.83	Yes	No	0	4	2
161	R:R:D210	R:R:V212	7.3	Yes	No	0	4	3
162	R:R:R216	R:R:V212	6.54	No	No	0	4	3
163	R:R:L284	R:R:Y214	8.21	Yes	No	0	5	1
164	R:R:H217	R:R:L284	6.43	No	Yes	0	4	5
165	R:R:M218	R:R:V222	4.56	No	No	0	1	4
166	R:R:R224	R:R:V220	5.23	Yes	Yes	0	5	5
167	R:R:L284	R:R:T221	5.9	Yes	No	0	5	6
168	R:R:F225	R:R:H277	6.79	No	No	0	5	8
169	R:R:F225	R:R:L281	4.87	No	No	0	5	5
170	R:R:G228	R:R:P232	4.06	No	Yes	0	6	9
171	R:R:F229	R:R:F270	6.43	No	No	7	9	6
172	R:R:C274	R:R:F229	6.98	No	No	7	6	9
173	R:R:F229	R:R:H277	9.05	No	No	0	9	8
174	R:R:P232	R:R:V231	3.53	Yes	No	0	9	6
175	R:R:F269	R:R:V233	5.24	Yes	No	0	9	5
176	R:R:F269	R:R:I236	7.54	Yes	No	0	9	8
177	R:R:I266	R:R:T237	9.12	No	No	0	8	4
178	R:R:I262	R:R:Y240	8.46	No	Yes	0	8	9
179	R:R:I265	R:R:Y240	12.09	Yes	Yes	2	8	9
180	R:R:I266	R:R:Y240	3.63	No	Yes	0	8	9
181	R:R:Y240	R:R:Y316	3.97	Yes	Yes	2	9	9
182	R:R:F259	R:R:V244	7.87	Yes	No	0	7	5
183	R:R:I262	R:R:V244	4.61	No	No	0	8	5
184	R:R:C245	R:R:R249	4.18	No	No	0	4	5
185	R:R:K246	R:R:N250	4.2	Yes	No	0	5	5
186	R:R:F259	R:R:Q248	7.03	Yes	No	0	7	5
187	R:R:A253	R:R:F259	4.16	No	Yes	0	5	7
188	R:R:K256	R:R:K260	8.62	No	No	0	5	5
189	R:R:K257	R:R:P258	5.02	No	No	0	7	7
190	R:R:F318	R:R:I261	6.28	No	Yes	0	6	8
191	R:R:I265	R:R:L315	7.14	Yes	No	0	8	7
192	R:R:I265	R:R:Y316	7.25	Yes	Yes	2	8	9
193	R:R:M311	R:R:T268	4.52	No	No	0	6	7
194	R:R:F269	R:R:W273	10.02	Yes	Yes	1	9	9
195	R:R:C274	R:R:F270	11.17	No	No	7	6	6
196	R:R:C272	R:R:N308	9.45	No	No	0	9	9
197	R:R:A305	R:R:W273	3.89	No	Yes	0	8	9
198	R:R:N308	R:R:W273	12.43	No	Yes	0	9	9
199	R:R:L304	R:R:P275	4.93	No	No	0	7	9
200	R:R:H277	R:R:Y276	6.53	No	Yes	0	8	6
201	R:R:N280	R:R:Y276	10.47	No	Yes	0	5	6
202	R:R:L279	R:R:L298	9.69	No	No	0	4	4
203	R:R:E283	R:R:N280	5.26	Yes	No	0	4	5
204	R:R:L282	R:R:M289	8.48	No	No	0	5	3
205	R:R:E283	R:R:F294	7	Yes	Yes	3	4	5
206	R:R:H285	R:R:T287	8.21	No	No	0	5	1
207	R:R:A288	R:R:H285	4.39	No	No	0	1	5
208	R:R:H286	R:R:T287	5.48	No	No	0	2	1
209	R:R:P290	R:R:S292	3.56	No	No	0	1	4
210	R:R:P290	R:R:V293	3.53	No	No	0	1	1
211	R:R:F294	R:R:L298	4.87	Yes	No	0	5	4
212	R:R:N312	R:R:P313	8.15	Yes	No	0	9	9
213	R:R:Q321	R:R:V317	5.73	Yes	No	0	5	7
214	R:R:G320	R:R:M319	5.24	No	No	0	8	6
215	R:R:M319	R:R:Q321	8.16	No	Yes	0	6	5
216	R:R:F323	R:R:G320	6.02	No	No	0	8	8
217	R:R:K324	R:R:K327	5.75	No	No	0	8	6
218	R:R:L43	R:R:Y47	3.52	No	Yes	0	6	8
219	R:R:P232	R:R:T131	3.5	Yes	No	0	9	7
220	R:R:P258	R:R:T255	3.5	No	No	0	7	6
221	R:R:C310	R:R:V50	3.42	No	No	0	8	7
222	R:R:A82	R:R:V61	3.39	No	No	0	8	9
223	R:R:F168	R:R:H121	3.39	Yes	Yes	0	3	5
224	R:R:C138	R:R:T242	3.38	No	No	0	8	4
225	R:R:A84	R:R:T125	3.36	No	Yes	0	8	7
226	R:R:A167	R:R:T125	3.36	No	Yes	0	8	7
227	R:R:D210	R:R:G213	3.35	Yes	No	0	4	3
228	L:L:G25	R:R:E283	3.27	No	Yes	0	0	4
229	R:R:C138	R:R:I243	3.27	No	No	0	8	8
230	R:R:A65	R:R:M75	3.22	No	No	0	6	8
231	R:R:V317	R:R:V61	3.21	No	No	0	7	9
232	R:R:F177	R:R:R216	3.21	Yes	No	0	4	4
233	R:R:C272	R:R:L304	3.17	No	No	0	9	7
234	R:R:I139	R:R:S147	3.1	No	No	0	5	4
235	R:R:I49	R:R:V45	3.07	No	No	0	4	5
236	L:L:P24	R:R:H217	3.05	No	No	0	0	4
237	R:R:K68	R:R:V328	3.04	No	No	0	4	3
238	R:R:M101	R:R:V106	3.04	No	No	0	4	3
239	R:R:I187	R:R:T180	3.04	No	No	0	5	4
240	R:R:L296	R:R:S295	3	No	No	0	1	4
241	R:R:L226	R:R:V222	2.98	No	No	0	4	4
242	R:R:I243	R:R:I262	2.94	No	No	0	8	8
243	R:R:I261	R:R:I265	2.94	Yes	Yes	0	8	8
244	R:R:I261	R:R:K257	2.91	Yes	No	0	8	7
245	R:R:D179	R:R:T180	2.89	No	No	0	4	4
246	R:R:I114	R:R:L118	2.85	No	No	0	4	5
247	R:R:I243	R:R:L247	2.85	No	No	0	8	8
248	R:R:L284	R:R:M218	2.83	Yes	No	0	5	1
249	R:R:L315	R:R:M311	2.83	No	No	0	7	6
250	R:R:G108	R:R:W105	2.81	No	Yes	0	8	9
251	R:R:H104	R:R:V106	2.77	No	No	0	5	3
252	R:R:A181	R:R:F190	2.77	No	Yes	0	2	3
253	R:R:L226	R:R:L230	2.77	No	No	0	4	4
254	R:R:L271	R:R:L304	2.77	No	No	0	6	7
255	R:R:L79	R:R:N80	2.75	No	No	0	5	9
256	R:R:L129	R:R:N80	2.75	No	No	0	8	9
257	R:R:I64	R:R:Q321	2.74	No	Yes	0	7	5
258	L:L:F27	R:R:S295	2.64	Yes	No	0	0	4
259	R:R:N149	R:R:Q148	2.64	No	No	0	4	4
260	R:R:F169	R:R:V165	2.62	No	No	0	3	4
261	R:R:A159	R:R:W77	2.59	No	Yes	0	5	7
262	R:R:F107	R:R:T97	2.59	Yes	No	0	8	4
263	R:R:F128	R:R:I163	2.51	No	No	0	6	7
264	R:R:F294	R:R:M289	2.49	Yes	No	0	5	3
265	R:R:K246	R:R:R249	2.48	Yes	No	0	5	5
266	R:R:V83	R:R:W164	2.45	No	No	0	6	9
267	R:R:F128	R:R:L166	2.44	No	No	0	6	4
268	R:R:F168	R:R:F169	2.14	Yes	No	0	3	3
269	R:R:G297	R:R:P299	2.03	No	No	0	5	3
270	R:R:C51	R:R:P93	1.88	No	No	0	6	8
271	R:R:A301	R:R:P275	1.87	No	No	0	7	9
272	R:R:G59	R:R:I63	1.76	No	No	0	3	3
273	R:R:C239	R:R:S135	1.72	No	No	0	7	6
274	R:R:A99	R:R:V44	1.7	No	No	0	5	5
275	R:R:A303	R:R:V46	1.7	No	No	0	5	5
276	R:R:A307	R:R:V50	1.7	No	No	0	5	7
277	R:R:M289	R:R:P290	1.68	No	No	0	3	1
278	R:R:C160	R:R:M161	1.62	No	No	0	7	4
279	R:R:A100	R:R:M101	1.61	No	No	0	5	4
280	R:R:V219	R:R:V220	1.6	No	Yes	0	3	5
281	R:R:T39	R:R:V38	1.59	No	No	0	4	4
282	R:R:C310	R:R:L53	1.59	No	No	0	8	5
283	R:R:C227	R:R:L170	1.59	No	No	0	4	5
284	L:L:A28	R:R:L298	1.58	No	No	0	0	4
285	R:R:T109	R:R:T180	1.57	No	No	0	3	4
286	R:R:I49	R:R:S48	1.55	No	No	0	4	4
287	R:R:I267	R:R:V263	1.54	No	No	0	5	4
288	R:R:I62	R:R:T66	1.52	No	No	0	7	4
289	R:R:I261	R:R:T264	1.52	Yes	No	0	8	5
290	R:R:M75	R:R:T72	1.51	No	No	0	8	7
291	R:R:L155	R:R:S152	1.5	No	No	0	3	6
292	R:R:L166	R:R:V162	1.49	No	No	0	4	4
293	R:R:N149	R:R:V145	1.48	No	No	0	4	5
294	R:R:L43	R:R:T39	1.47	No	No	0	6	4
295	R:R:L296	R:R:T39	1.47	No	No	0	1	4
296	R:R:L279	R:R:T278	1.47	No	No	0	4	5
297	R:R:L282	R:R:T278	1.47	No	No	0	5	5
298	R:R:I314	R:R:M311	1.46	No	No	0	6	6
299	R:R:K324	R:R:M69	1.44	No	No	0	8	5
300	R:R:I49	R:R:L53	1.43	No	No	0	4	5
301	R:R:K113	R:R:L175	1.41	No	No	0	7	4
302	R:R:L155	R:R:M158	1.41	No	No	0	3	3
303	R:R:D322	R:R:I64	1.4	No	No	0	6	7
304	R:R:L247	R:R:L252	1.38	No	No	0	8	3
305	R:R:I41	R:R:R37	1.25	No	No	0	5	3
306	R:R:F259	R:R:K256	1.24	Yes	No	0	7	5
307	R:R:F52	R:R:L53	1.22	No	No	0	5	5
308	R:R:L34	R:R:R37	1.21	No	No	0	3	3
309	R:R:D322	R:R:F326	1.19	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y22	10.968	5	3	0
2	L:L:F27	7.9025	4	3	0
3	L:L:F29	5.27	5	1	0
4	L:L:S30	6.2125	4	1	0
5	R:R:Y47	4.678	5	0	8
6	R:R:W77	6.12167	6	0	7
7	R:R:L81	6.5175	4	2	9
8	R:R:D85	8.28	4	2	9
9	R:R:F88	5.12857	7	1	8
10	R:R:L92	5.315	4	1	8
11	R:R:Y98	5.9375	4	0	5
12	R:R:Y103	5.6025	4	0	4
13	R:R:W105	10.392	5	5	9
14	R:R:F107	7.096	5	0	8
15	R:R:I120	5.215	4	1	4
16	R:R:H121	4.714	5	6	5
17	R:R:M123	5.7525	4	1	8
18	R:R:T125	6.9925	4	6	7
19	R:R:I133	4.87	4	2	9
20	R:R:D136	7.925	4	4	8
21	R:R:R151	10.305	4	4	6
22	R:R:F168	4.9725	4	0	3
23	R:R:F177	8.204	5	1	4
24	R:R:F190	9.975	4	0	3
25	R:R:N191	7.455	4	1	5
26	R:R:F193	13.2625	4	1	5
27	R:R:D210	5.3425	4	0	4
28	R:R:V220	5	4	0	5
29	R:R:R224	6.78	4	1	5
30	R:R:P232	3.655	4	0	9
31	R:R:Y240	8.95	6	2	9
32	R:R:K246	4.245	4	0	5
33	R:R:F259	5.075	4	0	7
34	R:R:I261	3.4125	4	0	8
35	R:R:I265	7.355	4	2	8
36	R:R:F269	7.01	4	1	9
37	R:R:W273	7.412	5	1	9
38	R:R:Y276	7.0375	4	1	6
39	R:R:E283	6.6875	4	3	4
40	R:R:L284	5.8425	4	0	5
41	R:R:F294	6.685	4	3	5
42	R:R:I306	5.045	4	1	7
43	R:R:N312	8.505	4	2	9
44	R:R:Y316	6.31	6	2	9
45	R:R:Q321	7.404	5	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q26	L:L:Y22	11.5763	6.76	No	Yes	3	0	0
2	L:L:Y22	R:R:E283	31.7205	11.22	Yes	Yes	3	0	4
3	L:L:F23	R:R:F190	10.2848	15	No	Yes	0	0	3
4	L:L:Q26	R:R:F190	11.7212	12.88	No	Yes	0	0	3
5	L:L:F27	R:R:Y103	19.0166	9.28	Yes	Yes	0	0	4
6	L:L:F29	R:R:Y276	10.7069	5.16	Yes	Yes	1	0	6
7	R:R:N280	R:R:Y276	43.5173	10.47	No	Yes	0	5	6
8	R:R:E283	R:R:N280	42.8148	5.26	Yes	No	0	4	5
9	L:L:F29	R:R:I120	57.9443	3.77	Yes	Yes	1	0	4
10	R:R:M123	R:R:Y276	37.6709	5.99	Yes	Yes	1	8	6
11	L:L:S30	R:R:I120	44.0559	4.64	Yes	Yes	1	0	4
12	L:L:S30	R:R:S174	13.9766	6.52	Yes	No	0	0	5
13	L:L:S30	R:R:N191	30.3156	4.47	Yes	Yes	1	0	5
14	R:R:I120	R:R:R224	13.9136	6.26	Yes	Yes	1	4	5
15	R:R:F88	R:R:M123	34.4327	4.98	Yes	Yes	1	8	8
16	R:R:F88	R:R:I306	14.1467	5.02	Yes	Yes	1	8	7
17	R:R:I306	R:R:V50	10.5809	4.61	Yes	No	0	7	7
18	R:R:I120	R:R:S171	13.356	6.19	Yes	No	0	4	7
19	R:R:H121	R:R:S171	12.096	5.58	Yes	No	0	5	7
20	R:R:F168	R:R:H121	21.5933	3.39	Yes	Yes	0	3	5
21	R:R:F117	R:R:F168	16.9439	6.43	No	Yes	0	5	3
22	R:R:F117	R:R:L118	13.3907	3.65	No	No	0	5	5
23	R:R:F91	R:R:L118	10.9904	9.74	No	No	0	6	5
24	R:R:F88	R:R:N122	18.6165	6.04	Yes	No	0	8	8
25	R:R:H121	R:R:N122	17.8794	3.83	Yes	No	0	5	8
26	R:R:M123	R:R:W273	100	5.82	Yes	Yes	1	8	9
27	R:R:F269	R:R:W273	93.9205	10.02	Yes	Yes	1	9	9
28	R:R:F269	R:R:I236	95.8672	7.54	Yes	No	0	9	8
29	R:R:I236	R:R:S134	95.5553	7.74	No	No	0	8	9
30	R:R:S134	R:R:Y240	95.2372	15.26	No	Yes	0	9	9
31	R:R:Y240	R:R:Y316	55.0589	3.97	Yes	Yes	2	9	9
32	R:R:L130	R:R:Y316	18.3204	7.03	No	Yes	2	8	9
33	R:R:L130	R:R:L81	11.5763	4.15	No	Yes	2	8	9
34	R:R:F78	R:R:Y316	18.1314	4.13	No	Yes	2	8	9
35	R:R:F78	R:R:V317	19.0355	5.24	No	No	0	8	7
36	R:R:Q321	R:R:V317	16.38	5.73	Yes	No	0	5	7
37	R:R:R137	R:R:Y240	22.3398	10.29	No	Yes	2	9	9
38	R:R:I133	R:R:R137	21.7004	3.76	Yes	No	2	9	9
39	R:R:I133	R:R:W77	44.9631	4.7	Yes	Yes	0	9	7
40	R:R:I133	R:R:Y316	23.2628	7.25	Yes	Yes	2	9	9
41	R:R:D136	R:R:W77	21.6752	11.17	Yes	Yes	0	8	7
42	R:R:Y103	R:R:Y98	15.5453	4.96	Yes	Yes	0	4	5
43	R:R:W105	R:R:Y98	15.6398	10.61	Yes	Yes	0	9	5
44	R:R:F107	R:R:W105	14.0585	15.03	Yes	Yes	0	8	9
45	R:R:F107	R:R:I94	23.1746	3.77	Yes	No	0	8	6
46	R:R:I94	R:R:S115	24.5606	6.19	No	No	0	6	5
47	R:R:F107	R:R:V106	25.1717	7.87	Yes	No	0	8	3
48	R:R:H104	R:R:V106	18.963	2.77	No	No	0	5	3
49	R:R:H104	R:R:I187	16.8809	6.63	No	No	0	5	5
50	R:R:N116	R:R:S115	25.9655	4.47	No	No	0	6	5
51	R:R:R178	R:R:S174	13.2237	3.95	No	No	0	5	5
52	R:R:N191	R:R:R178	15.9611	8.44	Yes	No	0	5	5
53	R:R:N116	R:R:R178	27.4554	16.87	No	No	0	6	5
54	R:R:D136	R:R:S140	16.4966	4.42	Yes	No	4	8	7
55	R:R:I262	R:R:Y240	21.5523	8.46	No	Yes	0	8	9
56	R:R:I243	R:R:I262	14.364	2.94	No	No	0	8	8
57	R:R:C138	R:R:I243	11.1479	3.27	No	No	0	8	8
58	R:R:S140	R:R:S147	14.7641	4.89	No	No	0	7	4
59	R:R:I139	R:R:S147	12.9402	3.1	No	No	0	5	4
60	R:R:I139	R:R:L143	11.1101	4.28	No	No	0	5	6
61	R:R:R224	R:R:V220	12.4079	5.23	Yes	Yes	0	5	5
62	R:R:F193	R:R:N191	10.2942	12.08	Yes	Yes	1	5	5
63	R:R:I187	R:R:T180	10.5966	3.04	No	No	0	5	4
64	R:R:F193	R:R:H217	17.9582	18.1	Yes	No	0	5	4
65	R:R:H217	R:R:L284	14.0648	6.43	No	Yes	0	4	5
66	L:L:F27	L:L:Y22	18.2984	10.32	Yes	Yes	3	0	0
67	L:L:F29	R:R:M123	47.0957	6.22	Yes	Yes	1	0	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y22	R:R:E283	11.22	3	Yes	Yes	0	4	0	1
L:L:Y22	R:R:H286	14.16	3	Yes	No	0	2	0	1
L:L:Y22	R:R:F294	12.38	3	Yes	Yes	0	5	0	1
L:L:F23	R:R:L183	3.65	0	No	No	0	1	0	1
L:L:F23	R:R:F190	15	0	No	Yes	0	3	0	1
L:L:Q26	R:R:F190	12.88	3	No	Yes	0	3	0	1
L:L:F27	R:R:Y103	9.28	3	Yes	Yes	0	4	0	1
L:L:F29	R:R:L119	7.31	1	Yes	No	0	6	0	1
L:L:F29	R:R:I120	3.77	1	Yes	Yes	0	4	0	1
L:L:F29	R:R:M123	6.22	1	Yes	Yes	0	8	0	1
L:L:F29	R:R:Y276	5.16	1	Yes	Yes	0	6	0	1
L:L:F29	R:R:T302	3.89	1	Yes	No	0	6	0	1
L:L:S30	R:R:I120	4.64	1	Yes	Yes	0	4	0	1
L:L:S30	R:R:S174	6.52	1	Yes	No	0	5	0	1
L:L:S30	R:R:N191	4.47	1	Yes	Yes	0	5	0	1
L:L:S30	R:R:R224	9.22	1	Yes	Yes	0	5	0	1
R:R:T302	R:R:Y47	4.99	0	No	Yes	6	8	1	2
R:R:F88	R:R:L119	7.31	1	Yes	No	8	6	2	1
R:R:F88	R:R:M123	4.98	1	Yes	Yes	8	8	2	1
R:R:Y103	R:R:Y98	4.96	0	Yes	Yes	4	5	1	2
R:R:S188	R:R:Y98	3.82	0	No	Yes	4	5	2	2
R:R:A99	R:R:Y103	4	0	No	Yes	5	4	2	1
R:R:P299	R:R:Y103	4.17	0	No	Yes	3	4	2	1
R:R:I120	R:R:S171	6.19	1	Yes	No	4	7	1	2
R:R:I120	R:R:R224	6.26	1	Yes	Yes	4	5	1	1
R:R:M123	R:R:W273	5.82	1	Yes	Yes	8	9	1	2
R:R:M123	R:R:Y276	5.99	1	Yes	Yes	8	6	1	1
R:R:F124	R:R:S171	5.28	0	No	No	7	7	2	2
R:R:F124	R:R:R224	6.41	0	No	Yes	7	5	2	1
R:R:R178	R:R:S174	3.95	0	No	No	5	5	2	1
R:R:F177	R:R:N191	4.83	1	Yes	Yes	4	5	2	1
R:R:F177	R:R:F193	15	1	Yes	Yes	4	5	2	2
R:R:N191	R:R:R178	8.44	1	Yes	No	5	5	1	2
R:R:H184	R:R:L183	6.43	0	No	No	2	1	2	1
R:R:F190	R:R:S188	9.25	0	Yes	No	3	4	1	2
R:R:F193	R:R:N191	12.08	1	Yes	Yes	5	5	2	1
R:R:F193	R:R:H217	18.1	1	Yes	No	5	4	2	1
R:R:F193	R:R:V220	7.87	1	Yes	Yes	5	5	2	2
R:R:H217	R:R:L284	6.43	0	No	Yes	4	5	1	2
R:R:R224	R:R:V220	5.23	1	Yes	Yes	5	5	1	2
R:R:H277	R:R:Y276	6.53	0	No	Yes	8	6	2	1
R:R:N280	R:R:Y276	10.47	0	No	Yes	5	6	2	1
R:R:L279	R:R:L298	9.69	0	No	No	4	4	2	1
R:R:E283	R:R:N280	5.26	3	Yes	No	4	5	1	2
R:R:E283	R:R:F294	7	3	Yes	Yes	4	5	1	1
R:R:H286	R:R:T287	5.48	0	No	No	2	1	1	2
R:R:F294	R:R:L298	4.87	3	Yes	No	5	4	1	1
L:L:G25	R:R:E283	3.27	0	No	Yes	0	4	0	1
L:L:P24	R:R:H217	3.05	0	No	No	0	4	0	1
R:R:L296	R:R:S295	3	0	No	No	1	4	2	1
R:R:A181	R:R:F190	2.77	0	No	Yes	2	3	2	1
L:L:F27	R:R:S295	2.64	3	Yes	No	0	4	0	1
R:R:F294	R:R:M289	2.49	3	Yes	No	5	3	1	2
L:L:A28	R:R:L298	1.58	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YKD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	279
Number of Links	309
Number of Hubs	45
Number of Links mediated by Hubs	157
Number of Communities	7
Number of Nodes involved in Communities	45
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	58066
Length Of Smallest Path	3
Average Path Length	14.6779
Length of Longest Path	34
Minimum Path Strength	1.23
Average Path Strength	6.63474
Maximum Path Strength	16.55
Minimum Path Correlation	0.7
Average Path Correlation	0.925956
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	44.7731
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3258
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99788
Sequence	>7YKD_nogp_Chain_R L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K M K K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D Y H W V F G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L P V W S Q N H R S V R L A Y M A C M V I W V L A F F L S S P S L V F R D T A N L H G K I S C F N N F S L S D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R L A K T K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H T A M P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D F K K F K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YKD	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	7YKD (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	8SG1	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8SG1 (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8ZJG	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	8ZJG (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	9L3W	A	Protein	Chemerin	CML1	Homo sapiens	Retinoic acid receptor responder protein 2	-	Gi1/β1/γ2	3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3W (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Retinoic acid receptor responder protein 2	-		3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Z	A	Protein	Chemerin	CML1	Homo sapiens	LRH7-C2	-	-	3.9	2025-03-12	doi.org/10.1093/procel/pwae073

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