psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q153	L:L:Y149	6.76	No	Yes	3	6	5
2	L:L:F154	L:L:Y149	10.32	Yes	Yes	3	6	5
3	L:L:Y149	R:R:E283	11.22	Yes	Yes	3	5	4
4	L:L:Y149	R:R:H286	14.16	Yes	No	0	5	2
5	L:L:Y149	R:R:F294	12.38	Yes	Yes	3	5	5
6	L:L:F150	R:R:L183	3.65	No	No	0	4	1
7	L:L:F150	R:R:F190	15	No	Yes	0	4	3
8	L:L:F154	L:L:Q153	9.37	Yes	No	3	6	6
9	L:L:Q153	R:R:F190	12.88	No	Yes	0	6	3
10	L:L:F154	R:R:Y103	9.28	Yes	Yes	0	6	4
11	L:L:F156	R:R:L119	7.31	Yes	No	0	9	6
12	L:L:F156	R:R:I120	3.77	Yes	Yes	1	9	4
13	L:L:F156	R:R:M123	6.22	Yes	Yes	1	9	8
14	L:L:F156	R:R:Y276	5.16	Yes	Yes	1	9	6
15	L:L:F156	R:R:T302	3.89	Yes	No	0	9	6
16	L:L:S157	R:R:I120	4.64	Yes	Yes	1	5	4
17	L:L:S157	R:R:S174	6.52	Yes	No	0	5	5
18	L:L:S157	R:R:N191	4.47	Yes	Yes	1	5	5
19	L:L:S157	R:R:R224	9.22	Yes	Yes	1	5	5
20	R:R:R37	R:R:R40	8.53	No	No	0	3	4
21	R:R:D102	R:R:R40	14.29	No	No	0	4	4
22	R:R:F42	R:R:V46	3.93	No	No	0	5	5
23	R:R:L300	R:R:L43	6.92	No	No	0	5	6
24	R:R:I96	R:R:Y47	6.04	No	Yes	0	7	8
25	R:R:T302	R:R:Y47	4.99	No	Yes	0	6	8
26	R:R:A303	R:R:Y47	4	No	Yes	0	5	8
27	R:R:I306	R:R:Y47	4.84	Yes	Yes	0	7	8
28	R:R:I306	R:R:V50	4.61	Yes	No	0	7	7
29	R:R:C51	R:R:L92	4.76	No	Yes	0	6	8
30	R:R:G54	R:R:N89	6.79	No	No	0	8	6
31	R:R:F86	R:R:I55	3.77	No	No	0	8	5
32	R:R:L56	R:R:L60	4.15	No	No	0	5	6
33	R:R:G57	R:R:L60	5.13	No	No	0	7	6
34	R:R:D85	R:R:N58	6.73	Yes	No	0	9	9
35	R:R:N58	R:R:P313	8.15	No	No	0	9	9
36	R:R:G59	R:R:I62	5.29	No	No	0	3	7
37	R:R:F86	R:R:I62	5.02	No	No	0	8	7
38	R:R:I64	R:R:K325	8.72	No	No	0	7	5
39	R:R:A65	R:R:L79	6.3	No	No	0	6	5
40	R:R:F67	R:R:T66	10.38	No	No	0	5	4
41	R:R:K325	R:R:K68	11.49	No	No	0	5	4
42	R:R:M69	R:R:Q321	16.31	No	Yes	0	5	5
43	R:R:K70	R:R:T72	4.5	No	No	0	6	7
44	R:R:K71	R:R:Y157	3.58	No	No	0	6	3
45	R:R:V73	R:R:W77	3.68	No	Yes	0	6	7
46	R:R:R151	R:R:V73	14.38	Yes	No	0	6	6
47	R:R:D136	R:R:N74	5.39	Yes	No	4	8	8
48	R:R:N74	R:R:R151	10.85	No	Yes	4	8	6
49	R:R:M75	R:R:Q321	4.08	No	Yes	0	8	5
50	R:R:A156	R:R:V76	5.09	No	No	0	7	6
51	R:R:V76	R:R:Y157	10.09	No	No	0	6	3
52	R:R:I132	R:R:W77	9.4	No	Yes	0	6	7
53	R:R:I133	R:R:W77	4.7	Yes	Yes	0	9	7
54	R:R:D136	R:R:W77	11.17	Yes	Yes	0	8	7
55	R:R:A156	R:R:W77	5.19	No	Yes	0	7	7
56	R:R:F78	R:R:I133	3.77	No	Yes	2	8	9
57	R:R:F78	R:R:Y316	4.13	No	Yes	2	8	9
58	R:R:F78	R:R:V317	5.24	No	No	0	8	7
59	R:R:C160	R:R:N80	7.87	No	No	0	7	9
60	R:R:D85	R:R:L81	6.79	Yes	Yes	2	9	9
61	R:R:L129	R:R:L81	4.15	No	Yes	0	8	9
62	R:R:L130	R:R:L81	4.15	No	Yes	2	8	9
63	R:R:L81	R:R:N312	10.98	Yes	Yes	2	9	9
64	R:R:D85	R:R:S126	8.83	Yes	No	0	9	9
65	R:R:D85	R:R:N312	10.77	Yes	Yes	2	9	9
66	R:R:F86	R:R:V90	7.87	No	No	0	8	5
67	R:R:L87	R:R:N122	6.87	No	No	0	7	8
68	R:R:F88	R:R:N89	3.62	Yes	No	1	8	6
69	R:R:F88	R:R:L92	3.65	Yes	Yes	1	8	8
70	R:R:F88	R:R:L119	7.31	Yes	No	0	8	6
71	R:R:F88	R:R:N122	6.04	Yes	No	0	8	8
72	R:R:F88	R:R:M123	4.98	Yes	Yes	1	8	8
73	R:R:F88	R:R:I306	5.02	Yes	Yes	1	8	7
74	R:R:F88	R:R:S309	5.28	Yes	No	1	8	9
75	R:R:N89	R:R:S309	4.47	No	No	1	6	9
76	R:R:F91	R:R:V90	3.93	No	No	0	6	5
77	R:R:F91	R:R:L118	9.74	No	No	0	6	5
78	R:R:I96	R:R:L92	7.14	No	Yes	0	7	8
79	R:R:I306	R:R:L92	5.71	Yes	Yes	1	7	8
80	R:R:F107	R:R:I94	3.77	Yes	No	0	8	6
81	R:R:I94	R:R:S115	6.19	No	No	0	6	5
82	R:R:H95	R:R:Y98	4.36	No	Yes	0	6	5
83	R:R:Y103	R:R:Y98	4.96	Yes	Yes	0	4	5
84	R:R:W105	R:R:Y98	10.61	Yes	Yes	0	9	5
85	R:R:S188	R:R:Y98	3.82	No	Yes	0	4	5
86	R:R:A99	R:R:Y103	4	No	Yes	0	5	4
87	R:R:D102	R:R:K186	5.53	No	No	0	4	2
88	R:R:P299	R:R:Y103	4.17	No	Yes	0	3	4
89	R:R:H104	R:R:I187	6.63	No	No	0	5	5
90	R:R:F107	R:R:W105	15.03	Yes	Yes	0	8	9
91	R:R:C112	R:R:W105	13.06	No	Yes	5	9	9
92	R:R:C189	R:R:W105	10.45	No	Yes	5	9	9
93	R:R:F107	R:R:V106	7.87	Yes	No	0	8	3
94	R:R:F107	R:R:M111	6.22	Yes	No	0	8	6
95	R:R:C112	R:R:C189	7.28	No	No	5	9	9
96	R:R:N116	R:R:S115	4.47	No	No	0	6	5
97	R:R:N116	R:R:R178	16.87	No	No	0	6	5
98	R:R:F117	R:R:L118	3.65	No	No	0	5	5
99	R:R:F117	R:R:F168	6.43	No	Yes	0	5	3
100	R:R:F117	R:R:L175	13.4	No	No	0	5	4
101	R:R:I120	R:R:S171	6.19	Yes	No	0	4	7
102	R:R:I120	R:R:R224	6.26	Yes	Yes	1	4	5
103	R:R:H121	R:R:N122	3.83	Yes	No	0	5	8
104	R:R:H121	R:R:T125	5.48	Yes	Yes	6	5	7
105	R:R:H121	R:R:W164	5.29	Yes	No	6	5	9
106	R:R:H121	R:R:S171	5.58	Yes	No	0	5	7
107	R:R:M123	R:R:W273	5.82	Yes	Yes	1	8	9
108	R:R:M123	R:R:Y276	5.99	Yes	Yes	1	8	6
109	R:R:F124	R:R:L170	7.31	No	No	0	7	5
110	R:R:F124	R:R:S171	5.28	No	No	0	7	7
111	R:R:F124	R:R:R224	6.41	No	Yes	0	7	5
112	R:R:T125	R:R:W164	15.77	Yes	No	6	7	9
113	R:R:P232	R:R:V127	3.53	Yes	No	0	9	7
114	R:R:F269	R:R:V127	5.24	Yes	No	1	9	7
115	R:R:V127	R:R:W273	4.9	No	Yes	1	7	9
116	R:R:I163	R:R:L129	5.71	No	No	0	7	8
117	R:R:L130	R:R:N312	4.12	No	Yes	2	8	9
118	R:R:L130	R:R:Y316	7.03	No	Yes	2	8	9
119	R:R:I235	R:R:T131	4.56	No	No	0	7	7
120	R:R:I132	R:R:I163	4.42	No	No	0	6	7
121	R:R:I133	R:R:R137	3.76	Yes	No	2	9	9
122	R:R:I133	R:R:Y316	7.25	Yes	Yes	2	9	9
123	R:R:I236	R:R:S134	7.74	No	No	0	8	9
124	R:R:S134	R:R:Y240	15.26	No	Yes	0	9	9
125	R:R:D136	R:R:S140	4.42	Yes	No	4	8	7
126	R:R:D136	R:R:R151	10.72	Yes	Yes	4	8	6
127	R:R:R137	R:R:Y240	10.29	No	Yes	2	9	9
128	R:R:R137	R:R:Y316	8.23	No	Yes	2	9	9
129	R:R:C138	R:R:C239	7.28	No	No	0	8	7
130	R:R:I139	R:R:L143	4.28	No	No	0	5	6
131	R:R:S140	R:R:S147	4.89	No	No	0	7	4
132	R:R:R151	R:R:S140	5.27	Yes	No	4	6	7
133	R:R:K246	R:R:V141	6.07	Yes	No	0	5	8
134	R:R:L142	R:R:T242	4.42	No	No	0	7	4
135	R:R:K246	R:R:L142	4.23	Yes	No	0	5	7
136	R:R:L143	R:R:W146	5.69	No	No	0	6	4
137	R:R:H150	R:R:W146	19.04	No	No	0	4	4
138	R:R:H150	R:R:N149	3.83	No	No	0	4	4
139	R:R:V153	R:R:Y157	5.05	No	No	0	2	3
140	R:R:M158	R:R:R154	3.72	No	No	0	3	5
141	R:R:F168	R:R:S172	7.93	Yes	No	0	3	4
142	R:R:P173	R:R:V220	5.3	No	Yes	0	8	5
143	R:R:R178	R:R:S174	3.95	No	No	0	5	5
144	R:R:F177	R:R:V176	13.11	Yes	No	0	4	4
145	R:R:F177	R:R:N191	4.83	Yes	Yes	1	4	5
146	R:R:F177	R:R:F193	15	Yes	Yes	1	4	5
147	R:R:F177	R:R:L195	4.87	Yes	No	0	4	4
148	R:R:N191	R:R:R178	8.44	Yes	No	0	5	5
149	R:R:D179	R:R:N192	5.39	No	No	0	4	2
150	R:R:G185	R:R:N182	5.09	No	No	0	6	1
151	R:R:I187	R:R:N182	7.08	No	No	0	5	1
152	R:R:H184	R:R:L183	6.43	No	No	0	2	1
153	R:R:H184	R:R:K186	10.48	No	No	0	2	2
154	R:R:F190	R:R:S188	9.25	Yes	No	0	3	4
155	R:R:F193	R:R:N191	12.08	Yes	Yes	1	5	5
156	R:R:N192	R:R:S196	7.45	No	No	0	2	2
157	R:R:F193	R:R:H217	18.1	Yes	No	0	5	4
158	R:R:F193	R:R:V220	7.87	Yes	Yes	0	5	5
159	R:R:D210	R:R:S194	5.89	Yes	No	0	4	3
160	R:R:D210	R:R:P211	4.83	Yes	No	0	4	2
161	R:R:D210	R:R:V212	7.3	Yes	No	0	4	3
162	R:R:R216	R:R:V212	6.54	No	No	0	4	3
163	R:R:L284	R:R:Y214	8.21	Yes	No	0	5	1
164	R:R:H217	R:R:L284	6.43	No	Yes	0	4	5
165	R:R:M218	R:R:V222	4.56	No	No	0	1	4
166	R:R:R224	R:R:V220	5.23	Yes	Yes	0	5	5
167	R:R:L284	R:R:T221	5.9	Yes	No	0	5	6
168	R:R:F225	R:R:H277	6.79	No	No	0	5	8
169	R:R:F225	R:R:L281	4.87	No	No	0	5	5
170	R:R:G228	R:R:P232	4.06	No	Yes	0	6	9
171	R:R:F229	R:R:F270	6.43	No	No	7	9	6
172	R:R:C274	R:R:F229	6.98	No	No	7	6	9
173	R:R:F229	R:R:H277	9.05	No	No	0	9	8
174	R:R:P232	R:R:V231	3.53	Yes	No	0	9	6
175	R:R:F269	R:R:V233	5.24	Yes	No	0	9	5
176	R:R:F269	R:R:I236	7.54	Yes	No	0	9	8
177	R:R:I266	R:R:T237	9.12	No	No	0	8	4
178	R:R:I262	R:R:Y240	8.46	No	Yes	0	8	9
179	R:R:I265	R:R:Y240	12.09	Yes	Yes	2	8	9
180	R:R:I266	R:R:Y240	3.63	No	Yes	0	8	9
181	R:R:Y240	R:R:Y316	3.97	Yes	Yes	2	9	9
182	R:R:F259	R:R:V244	7.87	Yes	No	0	7	5
183	R:R:I262	R:R:V244	4.61	No	No	0	8	5
184	R:R:C245	R:R:R249	4.18	No	No	0	4	5
185	R:R:K246	R:R:N250	4.2	Yes	No	0	5	5
186	R:R:F259	R:R:Q248	7.03	Yes	No	0	7	5
187	R:R:A253	R:R:F259	4.16	No	Yes	0	5	7
188	R:R:K256	R:R:K260	8.62	No	No	0	5	5
189	R:R:K257	R:R:P258	5.02	No	No	0	7	7
190	R:R:F318	R:R:I261	6.28	No	Yes	0	6	8
191	R:R:I265	R:R:L315	7.14	Yes	No	0	8	7
192	R:R:I265	R:R:Y316	7.25	Yes	Yes	2	8	9
193	R:R:M311	R:R:T268	4.52	No	No	0	6	7
194	R:R:F269	R:R:W273	10.02	Yes	Yes	1	9	9
195	R:R:C274	R:R:F270	11.17	No	No	7	6	6
196	R:R:C272	R:R:N308	9.45	No	No	0	9	9
197	R:R:A305	R:R:W273	3.89	No	Yes	0	8	9
198	R:R:N308	R:R:W273	12.43	No	Yes	0	9	9
199	R:R:L304	R:R:P275	4.93	No	No	0	7	9
200	R:R:H277	R:R:Y276	6.53	No	Yes	0	8	6
201	R:R:N280	R:R:Y276	10.47	No	Yes	0	5	6
202	R:R:L279	R:R:L298	9.69	No	No	0	4	4
203	R:R:E283	R:R:N280	5.26	Yes	No	0	4	5
204	R:R:L282	R:R:M289	8.48	No	No	0	5	3
205	R:R:E283	R:R:F294	7	Yes	Yes	3	4	5
206	R:R:H285	R:R:T287	8.21	No	No	0	5	1
207	R:R:A288	R:R:H285	4.39	No	No	0	1	5
208	R:R:H286	R:R:T287	5.48	No	No	0	2	1
209	R:R:P290	R:R:S292	3.56	No	No	0	1	4
210	R:R:P290	R:R:V293	3.53	No	No	0	1	1
211	R:R:F294	R:R:L298	4.87	Yes	No	0	5	4
212	R:R:N312	R:R:P313	8.15	Yes	No	0	9	9
213	R:R:Q321	R:R:V317	5.73	Yes	No	0	5	7
214	R:R:G320	R:R:M319	5.24	No	No	0	8	6
215	R:R:M319	R:R:Q321	8.16	No	Yes	0	6	5
216	R:R:F323	R:R:G320	6.02	No	No	0	8	8
217	R:R:K324	R:R:K327	5.75	No	No	0	8	6
218	R:R:L43	R:R:Y47	3.52	No	Yes	0	6	8
219	R:R:P232	R:R:T131	3.5	Yes	No	0	9	7
220	R:R:P258	R:R:T255	3.5	No	No	0	7	6
221	R:R:C310	R:R:V50	3.42	No	No	0	8	7
222	R:R:A82	R:R:V61	3.39	No	No	0	8	9
223	R:R:F168	R:R:H121	3.39	Yes	Yes	0	3	5
224	R:R:C138	R:R:T242	3.38	No	No	0	8	4
225	R:R:A84	R:R:T125	3.36	No	Yes	0	8	7
226	R:R:A167	R:R:T125	3.36	No	Yes	0	8	7
227	R:R:D210	R:R:G213	3.35	Yes	No	0	4	3
228	L:L:G152	R:R:E283	3.27	No	Yes	0	9	4
229	R:R:C138	R:R:I243	3.27	No	No	0	8	8
230	R:R:A65	R:R:M75	3.22	No	No	0	6	8
231	R:R:V317	R:R:V61	3.21	No	No	0	7	9
232	R:R:F177	R:R:R216	3.21	Yes	No	0	4	4
233	R:R:C272	R:R:L304	3.17	No	No	0	9	7
234	R:R:I139	R:R:S147	3.1	No	No	0	5	4
235	R:R:I49	R:R:V45	3.07	No	No	0	4	5
236	L:L:P151	R:R:H217	3.05	No	No	0	9	4
237	R:R:K68	R:R:V328	3.04	No	No	0	4	3
238	R:R:M101	R:R:V106	3.04	No	No	0	4	3
239	R:R:I187	R:R:T180	3.04	No	No	0	5	4
240	R:R:L296	R:R:S295	3	No	No	0	1	4
241	R:R:L226	R:R:V222	2.98	No	No	0	4	4
242	R:R:I243	R:R:I262	2.94	No	No	0	8	8
243	R:R:I261	R:R:I265	2.94	Yes	Yes	0	8	8
244	R:R:I261	R:R:K257	2.91	Yes	No	0	8	7
245	R:R:D179	R:R:T180	2.89	No	No	0	4	4
246	R:R:I114	R:R:L118	2.85	No	No	0	4	5
247	R:R:I243	R:R:L247	2.85	No	No	0	8	8
248	R:R:L284	R:R:M218	2.83	Yes	No	0	5	1
249	R:R:L315	R:R:M311	2.83	No	No	0	7	6
250	R:R:G108	R:R:W105	2.81	No	Yes	0	8	9
251	R:R:H104	R:R:V106	2.77	No	No	0	5	3
252	R:R:A181	R:R:F190	2.77	No	Yes	0	2	3
253	R:R:L226	R:R:L230	2.77	No	No	0	4	4
254	R:R:L271	R:R:L304	2.77	No	No	0	6	7
255	R:R:L79	R:R:N80	2.75	No	No	0	5	9
256	R:R:L129	R:R:N80	2.75	No	No	0	8	9
257	R:R:I64	R:R:Q321	2.74	No	Yes	0	7	5
258	L:L:F154	R:R:S295	2.64	Yes	No	0	6	4
259	R:R:N149	R:R:Q148	2.64	No	No	0	4	4
260	R:R:F169	R:R:V165	2.62	No	No	0	3	4
261	R:R:A159	R:R:W77	2.59	No	Yes	0	5	7
262	R:R:F107	R:R:T97	2.59	Yes	No	0	8	4
263	R:R:F128	R:R:I163	2.51	No	No	0	6	7
264	R:R:F294	R:R:M289	2.49	Yes	No	0	5	3
265	R:R:K246	R:R:R249	2.48	Yes	No	0	5	5
266	R:R:V83	R:R:W164	2.45	No	No	0	6	9
267	R:R:F128	R:R:L166	2.44	No	No	0	6	4
268	R:R:F168	R:R:F169	2.14	Yes	No	0	3	3
269	R:R:G297	R:R:P299	2.03	No	No	0	5	3
270	R:R:C51	R:R:P93	1.88	No	No	0	6	8
271	R:R:A301	R:R:P275	1.87	No	No	0	7	9
272	R:R:G59	R:R:I63	1.76	No	No	0	3	3
273	R:R:C239	R:R:S135	1.72	No	No	0	7	6
274	R:R:A99	R:R:V44	1.7	No	No	0	5	5
275	R:R:A303	R:R:V46	1.7	No	No	0	5	5
276	R:R:A307	R:R:V50	1.7	No	No	0	5	7
277	R:R:M289	R:R:P290	1.68	No	No	0	3	1
278	R:R:C160	R:R:M161	1.62	No	No	0	7	4
279	R:R:A100	R:R:M101	1.61	No	No	0	5	4
280	R:R:V219	R:R:V220	1.6	No	Yes	0	3	5
281	R:R:T39	R:R:V38	1.59	No	No	0	4	4
282	R:R:C310	R:R:L53	1.59	No	No	0	8	5
283	R:R:C227	R:R:L170	1.59	No	No	0	4	5
284	L:L:A155	R:R:L298	1.58	No	No	0	9	4
285	R:R:T109	R:R:T180	1.57	No	No	0	3	4
286	R:R:I49	R:R:S48	1.55	No	No	0	4	4
287	R:R:I267	R:R:V263	1.54	No	No	0	5	4
288	R:R:I62	R:R:T66	1.52	No	No	0	7	4
289	R:R:I261	R:R:T264	1.52	Yes	No	0	8	5
290	R:R:M75	R:R:T72	1.51	No	No	0	8	7
291	R:R:L155	R:R:S152	1.5	No	No	0	3	6
292	R:R:L166	R:R:V162	1.49	No	No	0	4	4
293	R:R:N149	R:R:V145	1.48	No	No	0	4	5
294	R:R:L43	R:R:T39	1.47	No	No	0	6	4
295	R:R:L296	R:R:T39	1.47	No	No	0	1	4
296	R:R:L279	R:R:T278	1.47	No	No	0	4	5
297	R:R:L282	R:R:T278	1.47	No	No	0	5	5
298	R:R:I314	R:R:M311	1.46	No	No	0	6	6
299	R:R:K324	R:R:M69	1.44	No	No	0	8	5
300	R:R:I49	R:R:L53	1.43	No	No	0	4	5
301	R:R:K113	R:R:L175	1.41	No	No	0	7	4
302	R:R:L155	R:R:M158	1.41	No	No	0	3	3
303	R:R:D322	R:R:I64	1.4	No	No	0	6	7
304	R:R:L247	R:R:L252	1.38	No	No	0	8	3
305	R:R:I41	R:R:R37	1.25	No	No	0	5	3
306	R:R:F259	R:R:K256	1.24	Yes	No	0	7	5
307	R:R:F52	R:R:L53	1.22	No	No	0	5	5
308	R:R:L34	R:R:R37	1.21	No	No	0	3	3
309	R:R:D322	R:R:F326	1.19	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y149	10.968	5	3	5
2	L:L:F154	7.9025	4	3	6
3	L:L:F156	5.27	5	1	9
4	L:L:S157	6.2125	4	1	5
5	R:R:Y47	4.678	5	0	8
6	R:R:W77	6.12167	6	0	7
7	R:R:L81	6.5175	4	2	9
8	R:R:D85	8.28	4	2	9
9	R:R:F88	5.12857	7	1	8
10	R:R:L92	5.315	4	1	8
11	R:R:Y98	5.9375	4	0	5
12	R:R:Y103	5.6025	4	0	4
13	R:R:W105	10.392	5	5	9
14	R:R:F107	7.096	5	0	8
15	R:R:I120	5.215	4	1	4
16	R:R:H121	4.714	5	6	5
17	R:R:M123	5.7525	4	1	8
18	R:R:T125	6.9925	4	6	7
19	R:R:I133	4.87	4	2	9
20	R:R:D136	7.925	4	4	8
21	R:R:R151	10.305	4	4	6
22	R:R:F168	4.9725	4	0	3
23	R:R:F177	8.204	5	1	4
24	R:R:F190	9.975	4	0	3
25	R:R:N191	7.455	4	1	5
26	R:R:F193	13.2625	4	1	5
27	R:R:D210	5.3425	4	0	4
28	R:R:V220	5	4	0	5
29	R:R:R224	6.78	4	1	5
30	R:R:P232	3.655	4	0	9
31	R:R:Y240	8.95	6	2	9
32	R:R:K246	4.245	4	0	5
33	R:R:F259	5.075	4	0	7
34	R:R:I261	3.4125	4	0	8
35	R:R:I265	7.355	4	2	8
36	R:R:F269	7.01	4	1	9
37	R:R:W273	7.412	5	1	9
38	R:R:Y276	7.0375	4	1	6
39	R:R:E283	6.6875	4	3	4
40	R:R:L284	5.8425	4	0	5
41	R:R:F294	6.685	4	3	5
42	R:R:I306	5.045	4	1	7
43	R:R:N312	8.505	4	2	9
44	R:R:Y316	6.31	6	2	9
45	R:R:Q321	7.404	5	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q153	L:L:Y149	11.5763	6.76	No	Yes	3	6	5
2	L:L:Y149	R:R:E283	31.7205	11.22	Yes	Yes	3	5	4
3	L:L:F150	R:R:F190	10.2848	15	No	Yes	0	4	3
4	L:L:Q153	R:R:F190	11.7212	12.88	No	Yes	0	6	3
5	L:L:F154	R:R:Y103	19.0166	9.28	Yes	Yes	0	6	4
6	L:L:F156	R:R:Y276	10.7069	5.16	Yes	Yes	1	9	6
7	R:R:N280	R:R:Y276	43.5173	10.47	No	Yes	0	5	6
8	R:R:E283	R:R:N280	42.8148	5.26	Yes	No	0	4	5
9	L:L:F156	R:R:I120	57.9443	3.77	Yes	Yes	1	9	4
10	R:R:M123	R:R:Y276	37.6709	5.99	Yes	Yes	1	8	6
11	L:L:S157	R:R:I120	44.0559	4.64	Yes	Yes	1	5	4
12	L:L:S157	R:R:S174	13.9766	6.52	Yes	No	0	5	5
13	L:L:S157	R:R:N191	30.3156	4.47	Yes	Yes	1	5	5
14	R:R:I120	R:R:R224	13.9136	6.26	Yes	Yes	1	4	5
15	R:R:F88	R:R:M123	34.4327	4.98	Yes	Yes	1	8	8
16	R:R:F88	R:R:I306	14.1467	5.02	Yes	Yes	1	8	7
17	R:R:I306	R:R:V50	10.5809	4.61	Yes	No	0	7	7
18	R:R:I120	R:R:S171	13.356	6.19	Yes	No	0	4	7
19	R:R:H121	R:R:S171	12.096	5.58	Yes	No	0	5	7
20	R:R:F168	R:R:H121	21.5933	3.39	Yes	Yes	0	3	5
21	R:R:F117	R:R:F168	16.9439	6.43	No	Yes	0	5	3
22	R:R:F117	R:R:L118	13.3907	3.65	No	No	0	5	5
23	R:R:F91	R:R:L118	10.9904	9.74	No	No	0	6	5
24	R:R:F88	R:R:N122	18.6165	6.04	Yes	No	0	8	8
25	R:R:H121	R:R:N122	17.8794	3.83	Yes	No	0	5	8
26	R:R:M123	R:R:W273	100	5.82	Yes	Yes	1	8	9
27	R:R:F269	R:R:W273	93.9205	10.02	Yes	Yes	1	9	9
28	R:R:F269	R:R:I236	95.8672	7.54	Yes	No	0	9	8
29	R:R:I236	R:R:S134	95.5553	7.74	No	No	0	8	9
30	R:R:S134	R:R:Y240	95.2372	15.26	No	Yes	0	9	9
31	R:R:Y240	R:R:Y316	55.0589	3.97	Yes	Yes	2	9	9
32	R:R:L130	R:R:Y316	18.3204	7.03	No	Yes	2	8	9
33	R:R:L130	R:R:L81	11.5763	4.15	No	Yes	2	8	9
34	R:R:F78	R:R:Y316	18.1314	4.13	No	Yes	2	8	9
35	R:R:F78	R:R:V317	19.0355	5.24	No	No	0	8	7
36	R:R:Q321	R:R:V317	16.38	5.73	Yes	No	0	5	7
37	R:R:R137	R:R:Y240	22.3398	10.29	No	Yes	2	9	9
38	R:R:I133	R:R:R137	21.7004	3.76	Yes	No	2	9	9
39	R:R:I133	R:R:W77	44.9631	4.7	Yes	Yes	0	9	7
40	R:R:I133	R:R:Y316	23.2628	7.25	Yes	Yes	2	9	9
41	R:R:D136	R:R:W77	21.6752	11.17	Yes	Yes	0	8	7
42	R:R:Y103	R:R:Y98	15.5453	4.96	Yes	Yes	0	4	5
43	R:R:W105	R:R:Y98	15.6398	10.61	Yes	Yes	0	9	5
44	R:R:F107	R:R:W105	14.0585	15.03	Yes	Yes	0	8	9
45	R:R:F107	R:R:I94	23.1746	3.77	Yes	No	0	8	6
46	R:R:I94	R:R:S115	24.5606	6.19	No	No	0	6	5
47	R:R:F107	R:R:V106	25.1717	7.87	Yes	No	0	8	3
48	R:R:H104	R:R:V106	18.963	2.77	No	No	0	5	3
49	R:R:H104	R:R:I187	16.8809	6.63	No	No	0	5	5
50	R:R:N116	R:R:S115	25.9655	4.47	No	No	0	6	5
51	R:R:R178	R:R:S174	13.2237	3.95	No	No	0	5	5
52	R:R:N191	R:R:R178	15.9611	8.44	Yes	No	0	5	5
53	R:R:N116	R:R:R178	27.4554	16.87	No	No	0	6	5
54	R:R:D136	R:R:S140	16.4966	4.42	Yes	No	4	8	7
55	R:R:I262	R:R:Y240	21.5523	8.46	No	Yes	0	8	9
56	R:R:I243	R:R:I262	14.364	2.94	No	No	0	8	8
57	R:R:C138	R:R:I243	11.1479	3.27	No	No	0	8	8
58	R:R:S140	R:R:S147	14.7641	4.89	No	No	0	7	4
59	R:R:I139	R:R:S147	12.9402	3.1	No	No	0	5	4
60	R:R:I139	R:R:L143	11.1101	4.28	No	No	0	5	6
61	R:R:R224	R:R:V220	12.4079	5.23	Yes	Yes	0	5	5
62	R:R:F193	R:R:N191	10.2942	12.08	Yes	Yes	1	5	5
63	R:R:I187	R:R:T180	10.5966	3.04	No	No	0	5	4
64	R:R:F193	R:R:H217	17.9582	18.1	Yes	No	0	5	4
65	R:R:H217	R:R:L284	14.0648	6.43	No	Yes	0	4	5
66	L:L:F154	L:L:Y149	18.2984	10.32	Yes	Yes	3	6	5
67	L:L:F156	R:R:M123	47.0957	6.22	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y149	R:R:E283	11.22	3	Yes	Yes	5	4	0	1
L:L:Y149	R:R:H286	14.16	3	Yes	No	5	2	0	1
L:L:Y149	R:R:F294	12.38	3	Yes	Yes	5	5	0	1
L:L:F150	R:R:L183	3.65	0	No	No	4	1	0	1
L:L:F150	R:R:F190	15	0	No	Yes	4	3	0	1
L:L:Q153	R:R:F190	12.88	3	No	Yes	6	3	0	1
L:L:F154	R:R:Y103	9.28	3	Yes	Yes	6	4	0	1
L:L:F156	R:R:L119	7.31	1	Yes	No	9	6	0	1
L:L:F156	R:R:I120	3.77	1	Yes	Yes	9	4	0	1
L:L:F156	R:R:M123	6.22	1	Yes	Yes	9	8	0	1
L:L:F156	R:R:Y276	5.16	1	Yes	Yes	9	6	0	1
L:L:F156	R:R:T302	3.89	1	Yes	No	9	6	0	1
L:L:S157	R:R:I120	4.64	1	Yes	Yes	5	4	0	1
L:L:S157	R:R:S174	6.52	1	Yes	No	5	5	0	1
L:L:S157	R:R:N191	4.47	1	Yes	Yes	5	5	0	1
L:L:S157	R:R:R224	9.22	1	Yes	Yes	5	5	0	1
R:R:T302	R:R:Y47	4.99	0	No	Yes	6	8	1	2
R:R:F88	R:R:L119	7.31	1	Yes	No	8	6	2	1
R:R:F88	R:R:M123	4.98	1	Yes	Yes	8	8	2	1
R:R:Y103	R:R:Y98	4.96	0	Yes	Yes	4	5	1	2
R:R:S188	R:R:Y98	3.82	0	No	Yes	4	5	2	2
R:R:A99	R:R:Y103	4	0	No	Yes	5	4	2	1
R:R:P299	R:R:Y103	4.17	0	No	Yes	3	4	2	1
R:R:I120	R:R:S171	6.19	1	Yes	No	4	7	1	2
R:R:I120	R:R:R224	6.26	1	Yes	Yes	4	5	1	1
R:R:M123	R:R:W273	5.82	1	Yes	Yes	8	9	1	2
R:R:M123	R:R:Y276	5.99	1	Yes	Yes	8	6	1	1
R:R:F124	R:R:S171	5.28	0	No	No	7	7	2	2
R:R:F124	R:R:R224	6.41	0	No	Yes	7	5	2	1
R:R:R178	R:R:S174	3.95	0	No	No	5	5	2	1
R:R:F177	R:R:N191	4.83	1	Yes	Yes	4	5	2	1
R:R:F177	R:R:F193	15	1	Yes	Yes	4	5	2	2
R:R:N191	R:R:R178	8.44	1	Yes	No	5	5	1	2
R:R:H184	R:R:L183	6.43	0	No	No	2	1	2	1
R:R:F190	R:R:S188	9.25	0	Yes	No	3	4	1	2
R:R:F193	R:R:N191	12.08	1	Yes	Yes	5	5	2	1
R:R:F193	R:R:H217	18.1	1	Yes	No	5	4	2	1
R:R:F193	R:R:V220	7.87	1	Yes	Yes	5	5	2	2
R:R:H217	R:R:L284	6.43	0	No	Yes	4	5	1	2
R:R:R224	R:R:V220	5.23	1	Yes	Yes	5	5	1	2
R:R:H277	R:R:Y276	6.53	0	No	Yes	8	6	2	1
R:R:N280	R:R:Y276	10.47	0	No	Yes	5	6	2	1
R:R:L279	R:R:L298	9.69	0	No	No	4	4	2	1
R:R:E283	R:R:N280	5.26	3	Yes	No	4	5	1	2
R:R:E283	R:R:F294	7	3	Yes	Yes	4	5	1	1
R:R:H286	R:R:T287	5.48	0	No	No	2	1	1	2
R:R:F294	R:R:L298	4.87	3	Yes	No	5	4	1	1
L:L:G152	R:R:E283	3.27	0	No	Yes	9	4	0	1
L:L:P151	R:R:H217	3.05	0	No	No	9	4	0	1
R:R:L296	R:R:S295	3	0	No	No	1	4	2	1
R:R:A181	R:R:F190	2.77	0	No	Yes	2	3	2	1
L:L:F154	R:R:S295	2.64	3	Yes	No	6	4	0	1
R:R:F294	R:R:M289	2.49	3	Yes	No	5	3	1	2
L:L:A155	R:R:L298	1.58	0	No	No	9	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YKD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	279
Number of Links	309
Number of Hubs	45
Number of Links mediated by Hubs	157
Number of Communities	7
Number of Nodes involved in Communities	45
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	58066
Length Of Smallest Path	3
Average Path Length	14.6779
Length of Longest Path	34
Minimum Path Strength	1.23
Average Path Strength	6.63474
Maximum Path Strength	16.55
Minimum Path Correlation	0.7
Average Path Correlation	0.925956
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	44.7731
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3258
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• humoral immune response • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • immune response • defense response to symbiont • response to external stimulus • antimicrobial humoral response • response to biotic stimulus • defense response to fungus • defense response to other organism • response to stress • immune system process • antifungal humoral response • response to external biotic stimulus • response to fungus • developmental process • cellular developmental process • cell differentiation • cellular process • chemotaxis • positive regulation of locomotion • regulation of biological process • regulation of response to external stimulus • biological regulation • positive regulation of biological process • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • response to activity • multicellular organismal process • digestive system development • tube development • animal organ development • embryo development • digestive tract development • multicellular organism development • anatomical structure development • embryonic organ development • embryonic digestive tract development • system development • innate immune response • lipid catabolic process • catabolic process • regulation of cellular process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • response to nutrient levels • response to caloric restriction • cellular response to stimulus • regulation of cell motility • macrophage migration • positive regulation of cell migration • cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • positive regulation of leukocyte chemotaxis • granulocyte migration • leukocyte migration • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • cell motility • positive regulation of cellular process • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • antifungal innate immune response • cellular response to nitrogen compound • signaling • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cell communication • cellular response to endogenous stimulus • response to hormone • signal transduction • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • response to insulin • cellular response to insulin stimulus • defense response to Gram-negative bacterium • defense response to bacterium • response to bacterium • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of phosphate metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • phosphate-containing compound metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • regulation of phosphorylation • macromolecule metabolic process • inflammatory response • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • regulation of fat cell differentiation • positive regulation of systemic arterial blood pressure • system process • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • regulation of biological quality • blood circulation • diterpenoid metabolic process • retinoid metabolic process • terpenoid metabolic process • isoprenoid metabolic process • defense response to Gram-positive bacterium • membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • vesicle lumen • intracellular anatomical structure • intracellular vesicle • membrane-enclosed lumen • cytoplasmic vesicle lumen • intracellular membrane-bounded organelle • secretory granule lumen • endomembrane system • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • platelet dense granule lumen • cytoplasmic vesicle • organelle lumen • platelet dense granule • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • cell periphery • extracellular matrix • external encapsulating structure • extracellular region • extracellular space • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • ciliary basal body • adipokinetic hormone binding • peptide hormone binding • hormone binding • molecular transducer activity • signaling receptor activity • protein-hormone receptor activity • adipokinetic hormone receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled chemoattractant receptor activity • chemokine receptor activity • cytokine receptor activity • immune receptor activity • complement receptor activity • positive regulation of cytosolic calcium ion concentration • immune response • skeletal system development • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • immune response-activating cell surface receptor signaling pathway • regulation of response to stimulus • regulation of immune response • activation of immune response • positive regulation of locomotion • regulation of cell motility • macrophage migration • positive regulation of chemotaxis • positive regulation of cell migration • taxis • regulation of mononuclear cell migration • chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of macrophage migration • response to external stimulus • positive regulation of leukocyte chemotaxis • granulocyte migration • regulation of locomotion • regulation of response to external stimulus • macrophage chemotaxis • regulation of granulocyte chemotaxis • regulation of macrophage migration • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • myeloid leukocyte migration • positive regulation of mononuclear cell migration • locomotion • cell chemotaxis • regulation of macrophage chemotaxis • positive regulation of leukocyte migration • regulation of chemotaxis • granulocyte chemotaxis • positive regulation of macrophage chemotaxis • leukocyte chemotaxis • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of signal transduction • regulation of intracellular signal transduction • calcium-mediated signaling • regulation of calcium-mediated signaling • defense response • response to stress • inflammatory response • regulation of interleukin-12 production • negative regulation of interleukin-12 production • cytokine production • regulation of cytokine production • interleukin-12 production • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	Chemerin-9
UniProt	Q99969
Sequence	>7YKD_nogp_Chain_L Y F P G Q F A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q99788
Sequence	>7YKD_nogp_Chain_R L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K M K K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D Y H W V F G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L P V W S Q N H R S V R L A Y M A C M V I W V L A F F L S S P S L V F R D T A N L H G K I S C F N N F S L S D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R L A K T K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H T A M P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D F K K F K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YKD	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	7YKD (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.81	2023-04-19	doi.org/10.1073/pnas.2214324120
	8SG1	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-	Gi1/β1/γ2	2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8SG1 (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin-9	-		2.94	2023-11-01	doi.org/10.1371/journal.pbio.3002188
	8ZJG	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	8ZJG (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.18	2025-01-22	doi.org/10.1038/s42003-024-07228-9
	9L3W	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-	Gi1/β1/γ2	3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3W (No Gprot)	A	Protein	Chemerin	CML1	Homo sapiens	Chemerin	-		3.5	2025-03-12	doi.org/10.1093/procel/pwae073
	9L3Z	A	Protein	Chemerin	CML1	Homo sapiens	LRH7-C2	-	-	3.9	2025-03-12	doi.org/10.1093/procel/pwae073

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