Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 4.996105
2A:A:L38 5.26408
3A:A:S44 4.5475469
4A:A:K46 5.7375469
5A:A:I49 4.228567
6A:A:H188 10.6075423
7A:A:F191 8.524105
8A:A:F196 8.86754107
9A:A:F199 7.33525
10A:A:K210 5.908589
11A:A:W211 6.0325429
12A:A:H213 5.825428
13A:A:F215 6.04667629
14A:A:I221 4.76254198
15A:A:F223 6.4025409
16A:A:C224 3.2725467
17A:A:M247 4.554206
18A:A:F250 6.81509
19A:A:C254 4.7954215
20A:A:W258 7.665625
21A:A:F267 4.73333669
22A:A:N269 4.775469
23A:A:F274 4.19409
24A:A:Y287 5.491437207
25A:A:Y290 8.4125407
26A:A:Y296 6.694504
27A:A:F307 5.3575408
28A:A:N311 4.5165218
29A:A:Y320 6.888336227
30A:A:T324 5.198569
31A:A:F336 5.99254108
32A:A:I343 4.6525407
33A:A:L348 3.93254279
34A:A:F354 9.1454265
35B:B:L7 3.1575408
36B:B:L14 3.515408
37B:B:L30 4.755405
38B:B:I37 4.54754112
39B:B:V40 3.785113
40B:B:L51 7.3459
41B:B:H54 8.78559
42B:B:I58 5.325459
43B:B:Y59 8.054528
44B:B:W63 6.9875497
45B:B:L69 3.32405
46B:B:V71 4.3875408
47B:B:S72 6.015459
48B:B:K78 4.315408
49B:B:L79 5.5385127
50B:B:I81 3.9525407
51B:B:W82 8.48167659
52B:B:N88 4.978507
53B:B:K89 7.51167659
54B:B:H91 4.6125405
55B:B:I93 5.174507
56B:B:L95 5.5125128
57B:B:W99 8.0075829
58B:B:Y105 3.771437126
59B:B:N110 7.2525434
60B:B:Y111 6.125434
61B:B:V112 4.50254128
62B:B:C114 4.61254128
63B:B:N119 4.23409
64B:B:I123 4.28636
65B:B:Y124 5.198506
66B:B:L126 4.934125
67B:B:L139 5.156539
68B:B:H142 8.13439
69B:B:Y145 5.95333688
70B:B:F151 4.19333639
71B:B:D154 6.135436
72B:B:I157 4.055437
73B:B:V158 3.545405
74B:B:T159 5.722539
75B:B:L168 5.0225446
76B:B:W169 8.79638
77B:B:I171 4.8275436
78B:B:F180 8.018547
79B:B:H183 8.22833649
80B:B:D186 6.3525489
81B:B:V187 6.125449
82B:B:V200 5.048516
83B:B:S201 5.2625449
84B:B:C204 5.108587
85B:B:D205 4.945449
86B:B:K209 10.5225446
87B:B:L210 4.57515
88B:B:W211 8.84333648
89B:B:F222 7.5325418
90B:B:H225 8.16625819
91B:B:D228 6.53489
92B:B:I232 3.832518
93B:B:F234 5.5725415
94B:B:F235 7.89754186
95B:B:P236 5.66754187
96B:B:F241 6.906516
97B:B:T243 6.24418
98B:B:D247 7.29619
99B:B:T249 7.52516
100B:B:R251 9.99833618
101B:B:F253 6.255616
102B:B:D258 7.958517
103B:B:Q259 4.525406
104B:B:M262 5.844154
105B:B:T263 5.4775411
106B:B:Y264 6.743336155
107B:B:H266 5.7125404
108B:B:C271 4.6075405
109B:B:F278 5.491676187
110B:B:R283 8.085119
111B:B:L284 5.4475405
112B:B:Y289 7.243336157
113B:B:W297 5.49754158
114B:B:H311 8.386676169
115B:B:W332 10.1386729
116B:B:D333 7.83254169
117B:B:F335 6.255404
118B:B:L336 5.386557
119B:B:K337 7.72754166
120B:B:W339 9.71754169
121G:G:D48 6.632509
122G:G:L51 5.1125116
123G:G:P60 6.765499
124G:G:F61 5.14857798
125R:R:Y60 5.2775478
126R:R:N71 7.535409
127R:R:V74 4.07754139
128R:R:V77 5.5425407
129R:R:L78 4.565137
130R:R:D89 5.32254138
131R:R:F91 5.93607
132R:R:V103 4.64406
133R:R:L106 6.108578
134R:R:W117 8.4456299
135R:R:F135 7.356577
136R:R:Y136 5.96506
137R:R:D148 6.512508
138R:R:R149 5.975149
139R:R:Y150 6.776308
140R:R:L151 5.5675405
141R:R:V168 3.965408
142R:R:F182 5.0525405
143R:R:F187 5.554504
144R:R:H193 12.54754313
145R:R:F207 4.5875404
146R:R:F224 10.8825408
147R:R:P227 4.06409
148R:R:Y235 6.616148
149R:R:R249 8.1554264
150R:R:W268 8.36679
151R:R:T269 4.74405
152R:R:Y271 6.44506
153R:R:H272 8.592578
154R:R:V275 5.014325
155R:R:I279 4.874325
156R:R:M281 3.566173
157R:R:D282 4.325172
158R:R:Y308 8.395476
159R:R:Y318 5.1085149
160R:R:F325 7.15138
161R:R:R328 3.43254135
162L:L:?1 11.0771070
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:V135 B:B:Y124 14.4166.31NoYes046
2B:B:R96 B:B:V135 14.51443.92NoNo064
3B:B:E138 B:B:R96 14.61453.49NoNo066
4B:B:E138 B:B:I120 14.7159.56NoNo066
5A:A:T181 B:B:I120 15.01876.08NoNo096
6A:A:T181 B:B:D118 15.2254.34NoNo099
7B:B:D118 B:B:S97 15.330411.78NoNo098
8B:B:S97 B:B:W99 15.43713.71NoYes089
9A:A:F215 B:B:W99 39.627315.03YesYes299
10A:A:F215 A:A:L37 60.42646.09YesNo299
11A:A:L37 A:A:L39 60.59836.92NoNo099
12A:A:I253 A:A:L39 59.02217.14NoNo089
13A:A:I253 A:A:L249 59.09864.28NoNo089
14A:A:F223 A:A:L249 59.3296.09YesNo099
15A:A:F223 A:A:G40 1003.01YesNo099
16A:A:G40 A:A:S44 49.90373.71NoYes699
17A:A:C224 A:A:S44 49.92413.44YesYes679
18A:A:C224 A:A:I49 99.85653.27YesYes677
19A:A:F267 A:A:I49 99.70687.54YesYes697
20A:A:F267 A:A:I265 97.4093.77YesNo098
21A:A:I222 A:A:I265 96.47852.94NoNo078
22A:A:I222 A:A:L36 96.44865.71NoNo077
23A:A:L36 A:A:V34 96.38862.98NoYes075
24A:A:V339 A:A:V34 47.82734.81NoYes1085
25A:A:I343 A:A:V339 48.02883.07YesNo078
26A:A:I343 A:A:N347 95.65884.25YesNo078
27A:A:N347 R:R:N152 95.5324.09NoNo088
28R:R:D148 R:R:N152 17.78474.04YesNo088
29A:A:G40 A:A:K46 50.15253.49NoYes699
30A:A:C224 A:A:K46 50.24413.23YesYes679
31A:A:V34 R:R:Y160 47.82745.05YesNo055
32A:A:I343 R:R:Y160 47.77519.67YesNo075
33A:A:I221 A:A:I264 25.72212.94YesNo086
34A:A:F250 A:A:I264 25.93985.02YesNo096
35A:A:M247 A:A:Y287 13.10684.79YesYes2067
36A:A:F215 A:A:W211 25.75663.01YesYes299
37A:A:Q204 A:A:W211 49.09956.57NoYes099
38A:A:Q204 B:B:Y145 47.93867.89NoYes098
39A:A:K210 B:B:Y145 35.20644.78YesYes898
40A:A:I212 A:A:W211 23.6563.52NoYes089
41A:A:F259 A:A:I212 23.73165.02NoNo098
42B:B:W332 B:B:Y59 22.57116.75YesYes298
43B:B:Q75 B:B:Y59 23.418214.65NoYes298
44B:B:R314 B:B:W332 15.287518.99NoYes289
45A:A:C351 R:R:N152 77.68924.72NoNo048
46A:A:C351 R:R:R149 77.45584.18NoYes049
47R:R:L85 R:R:T90 11.08572.95NoNo066
48R:R:T90 R:R:V168 11.39243.17NoYes068
49R:R:R149 R:R:Y235 38.49878.23YesYes1498
50A:A:K210 B:B:D228 33.99755.53YesYes899
51B:B:D228 B:B:D246 33.84923.99YesNo099
52B:B:D246 B:B:S227 33.45212.94NoNo096
53B:B:D247 B:B:S227 33.25342.94YesNo096
54B:B:D247 B:B:H225 19.18296.3YesYes199
55B:B:F253 B:B:H225 12.25674.53YesYes169
56B:B:F222 B:B:F253 16.34955.36YesYes186
57B:B:D258 B:B:F222 12.68794.78YesYes178
58B:B:D258 B:B:R22 10.667810.72YesNo076
59B:B:D247 B:B:R251 12.85673.57YesYes198
60B:B:F253 B:B:R251 12.25473.21YesYes168
61B:B:G162 B:B:Y145 12.2258.69NoYes898
62B:B:G162 B:B:S161 12.0333.71NoNo099
63B:B:H142 B:B:S161 10.592313.95YesNo099
64B:B:D290 B:B:R314 15.217615.48NoNo068
65B:B:C271 B:B:D290 15.11186.22YesNo056
66R:R:M231 R:R:Y235 37.12343.59NoYes1488
67R:R:F264 R:R:M231 36.98629.95NoNo098
68R:R:F264 R:R:W268 35.466715.03NoYes099
69L:L:?1 R:R:W268 38.79545.41YesYes709
70R:R:R149 R:R:Y318 36.63555.14YesYes1499
71R:R:N314 R:R:Y318 36.61044.65NoYes099
72R:R:H310 R:R:N314 36.466911.48NoNo099
73R:R:H310 R:R:W268 36.03719.52NoYes099
74R:R:L106 R:R:V103 11.58194.47YesYes086
75R:R:F135 R:R:W268 20.432711.02YesYes779
76R:R:F131 R:R:N132 16.32614.83NoNo054
77R:R:D186 R:R:N132 23.55888.08NoNo044
78R:R:D186 R:R:F187 21.75125.97NoYes044
79R:R:F135 R:R:Y136 11.77244.13YesYes076
80R:R:H272 R:R:W268 10.27425.29YesYes789
81R:R:F187 R:R:I188 14.50495.02YesNo044
82R:R:F189 R:R:I188 13.59896.28NoNo054
83R:R:F189 R:R:F207 12.69278.57NoYes054
84R:R:K300 R:R:Y271 10.30022.39NoYes056
85B:B:Q75 B:B:W99 24.05577.67NoYes299
86A:A:F223 A:A:F250 34.572412.86YesYes099
87A:A:F259 A:A:I221 23.74468.79NoYes1998
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L106 R:R:Y60 7.03 7 Yes Yes 8 8 2 1
R:R:A110 R:R:Y60 5.34 0 No Yes 7 8 2 1
R:R:Y308 R:R:Y60 3.97 7 Yes Yes 6 8 1 1
L:L:?1 R:R:Y60 4.77 7 Yes Yes 0 8 0 1
R:R:L106 R:R:Y308 3.52 7 Yes Yes 8 6 2 1
R:R:L108 R:R:W109 5.69 0 No No 6 5 2 1
L:L:?1 R:R:W109 11.59 7 Yes No 0 5 0 1
R:R:F131 R:R:N132 4.83 7 No No 5 4 1 2
R:R:F131 R:R:F135 7.5 7 No Yes 5 7 1 1
L:L:?1 R:R:F131 10.74 7 Yes No 0 5 0 1
R:R:N132 R:R:Y136 4.65 0 No Yes 4 6 2 2
R:R:F135 R:R:Y136 4.13 7 Yes Yes 7 6 1 2
R:R:F135 R:R:W268 11.02 7 Yes Yes 7 9 1 1
R:R:F135 R:R:H272 3.39 7 Yes Yes 7 8 1 2
L:L:?1 R:R:F135 10.74 7 Yes Yes 0 7 0 1
R:R:A139 R:R:W268 3.89 0 No Yes 8 9 2 1
R:R:F264 R:R:W268 15.03 0 No Yes 9 9 2 1
R:R:H272 R:R:W268 5.29 7 Yes Yes 8 9 2 1
R:R:H310 R:R:W268 9.52 0 No Yes 9 9 2 1
L:L:?1 R:R:W268 5.41 7 Yes Yes 0 9 0 1
R:R:H272 R:R:Y271 3.27 7 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 8.83 32 Yes Yes 5 6 2 1
R:R:T303 R:R:Y271 4.99 0 No Yes 7 6 2 1
L:L:?1 R:R:Y271 12.72 7 Yes Yes 0 6 0 1
R:R:S304 R:R:Y308 3.82 7 No Yes 5 6 1 1
L:L:?1 R:R:S304 23.43 7 Yes No 0 5 0 1
L:L:?1 R:R:G307 6.96 7 Yes No 0 8 0 1
L:L:?1 R:R:Y308 22.27 7 Yes Yes 0 6 0 1
R:R:K300 R:R:Y271 2.39 0 No Yes 5 6 2 1
L:L:?1 R:R:A113 2.14 7 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
72.73Single8Y0HVUF114188Y0H-CXCR3-VUF11418
63.64Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
62.50Single7SK9CCX6627SK9-ACKR3-CCX662
60.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
60.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
58.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
58.33Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
58.33Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
58.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
58.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
57.14Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
57.14Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
57.14Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
54.55Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
54.55Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
54.55Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
54.55Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
53.85Single2YDOAdenosine2YDO-A2A-Adenosine
53.85Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
53.85Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
53.85Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
53.85Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
53.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
53.33Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
53.33Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
50.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
50.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
50.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
50.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
50.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
50.00Single7K15MKD0467K15-BLT1-MKD046-Na
50.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
50.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
50.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
50.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
50.00Single8K5BNiacin8K5B-HCA2-Niacin
50.00Single8T1WCVN4248T1W-GPR6-CVN424
50.00Single8XYIVUF106618XYI-CXCR3-VUF10661
50.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
50.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
50.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
50.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
50.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
50.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
50.00Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
50.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
50.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
47.06Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.06Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.06Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.06Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
46.67Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
46.67Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
46.67Single6TP6Filorexant6TP6-OX1-Filorexant
46.67Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
46.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
46.67Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
46.67Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
46.67Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
46.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single4S0VSuvorexant4S0V-OX2-Suvorexant
46.15Single6AKXA4R6AKX-CCR5-A4R
46.15Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.15Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
46.15Single6TPJSuvorexant6TPJ-OX2-Suvorexant
46.15Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.15Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.15Single8IWESpermidine8IWE-TA9-Spermidine
46.15Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
46.15Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
46.15Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
46.15Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
46.15Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
46.15Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
46.15Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.15Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.15Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
46.15Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
45.45Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
44.44Single4UG2CGS216804UG2-A2A-CGS21680
44.44Single5ZTYAM102575ZTY-CB2-AM10257
44.44Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
43.75Single2YDVNECA2YDV-A2A-NECA
43.75Single4U15Tiotropium4U15-M3-Tiotropium
43.75Single4UHRCGS216804UHR-A2A-CGS21680
43.75Single5G53NECA5G53-A2A-NECA-Gs
43.75Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
43.75Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
43.75Single6OL9Tiotropium6OL9-M5-Tiotropium
43.75Single6TQ7SB-3348676TQ7-OX1-SB-334867
43.75Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
43.75Single8EA0Iperoxo8EA0-M3-Iperoxo
43.75Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
43.75Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
43.75Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
43.75Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
43.75Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
43.75Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
43.75Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
43.75Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
42.86Single4MBSMaraviroc4MBS-CCR5-Maraviroc
42.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
42.86Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
42.86Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
42.86Single6TP3Nemorexant6TP3-OX1-Nemorexant
42.86Single6TPGEMPA6TPG-OX2-EMPA
42.86Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
42.86Single6ZG9GSK10347026ZG9-M1-GSK1034702
42.86Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
42.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
42.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
42.86Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
42.86Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
42.86Single8K5CAcipimox8K5C-HCA2-Acipimox
42.86Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
42.86Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
42.86Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
42.86Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Consensusalpha1_onOrthosteric Ligandalpha1a_on
42.86Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
42.86Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
42.86Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
42.86Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
42.86Consensushca_onOrthosteric Ligandhca2_on
42.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
41.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
41.67Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
41.67Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
41.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
41.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single5CXVTiotropium5CXV-M1-Tiotropium
41.18Single6A93Risperidone6A93-5-HT2A-Risperidone
41.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7YITNalfurafine7YIT-κ-Nalfurafine
41.18Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
41.18Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
41.18Consensusalpha1_offOrthosteric Ligandalpha1a_off
41.18Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
41.18Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
41.18Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
41.18Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
41.18Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
41.18Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
41.18Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
41.18Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
41.18Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.18Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.00Single3NY8ICI118-5513NY8-β2-ICI118-551
40.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
40.00Single4DAJTiotropium4DAJ-M3-Tiotropium
40.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
40.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
40.00Single4MQSIperoxo4MQS-M2-Iperoxo
40.00Single4U14Tiotropium4U14-M3-Tiotropium
40.00Single4YAYZD-71554YAY-AT1-ZD-7155
40.00Single5DSGTiotropium5DSG-M4-Tiotropium
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single5TGZAM65385TGZ-CB1-AM6538
40.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
40.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
40.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
40.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
40.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8JJOAlprenolol8JJO-β2-Alprenolol
40.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
40.00Single8JXRLSD8JXR-D1-LSD
40.00Single8K5DGSK2560738K5D-HCA2-GSK256073
40.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
40.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
40.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
40.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
40.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
40.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
40.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
40.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
40.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
40.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
40.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
40.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
40.00Consensusblt_onOrthosteric Ligandblt1_on
40.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
40.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
40.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
40.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
40.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
40.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
40.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
40.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
40.00Consensusleukotriene_onOrthosteric Ligandblt_on
40.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
40.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
40.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
38.89Single5X93K-87945X93-ETB-K-8794
38.89Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
38.89Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
38.89Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.89Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
38.89Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
38.89Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
38.89Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.89Consensusendothelin_offOrthosteric Ligandetb_off
38.89Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
38.89Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.46Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
38.46Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
38.46Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
38.46Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
38.46Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
38.46Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
38.46Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
38.10Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
37.50Single2RH1S-Carazolol2RH1-β2-S-Carazolol
37.50Single2YCWS-Carazolol2YCW-β1-S-Carazolol
37.50Single5C1MBU725C1M-μ-BU72
37.50Single5CGCHTL142425CGC-mGlu5-HTL14242
37.50Single5D6LS-Carazolol5D6L-β2-S-Carazolol
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single5WQCEMPA5WQC-OX2-EMPA
37.50Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
37.50Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
37.50Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
37.50Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
37.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
37.50Single6PS6Timolol6PS6-β2-Timolol
37.50Single7C4SS1P7C4S-S1P3-S1P
37.50Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
37.50Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
37.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
37.50Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
37.50Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
37.50Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
37.50Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
37.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
37.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
37.50Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
37.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
37.50Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
37.50Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
37.50Consensusamine_offonOrthosteric Ligandamine_off amine_on
37.50Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
37.50Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
37.50Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
37.50Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
37.50Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
37.50Consensusblt_offOrthosteric Ligandblt1_off
37.50Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
37.50Consensusep_offOrthosteric Ligandep4_off
37.50Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
37.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Consensustrace-amine_onOrthosteric Ligandta1_on
36.84Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single8X5YAstemizole8X5Y-H1-Astemizole
36.84Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.84Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
36.84Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
36.36Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
36.36Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
36.36Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
35.71Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
35.71Single5WS3EMPA5WS3-OX2-EMPA
35.71Single5ZKQABT-4915ZKQ-PAF-ABT-491
35.71Single6B73MP11046B73-κ-MP1104
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
35.71Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
35.71Single6TODEMPA6TOD-OX1-EMPA-Na
35.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
35.71Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
35.71Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
35.71Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
35.71Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
35.71Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
35.71Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
35.71Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
35.71Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
35.71Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
35.71Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
35.71Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.71Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
35.71Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.71Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
35.71Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
35.71Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
35.71Consensusalpha2_offOrthosteric Ligandalpha2c_off
35.71Consensusangiotensin_offOrthosteric Ligandat1_off
35.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
35.71Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
35.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.71Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
35.71Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
35.71Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
35.71Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
35.29Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
35.29Single4DJHJDTic4DJH-κ-JDTic
35.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
35.29Single5D5AS-Carazolol5D5A-β2-S-Carazolol
35.29Single5D5BS-Carazolol5D5B-β2-S-Carazolol
35.29Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.29Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
35.29Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
35.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
35.29Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
35.29Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
35.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
35.29Single8E0GBU728E0G-μ-BU72
35.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
35.29Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
35.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
35.29Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
35.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
35.29Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
35.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
35.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
35.29Consensusa2_onOrthosteric Liganda2b_on
35.29Consensusa2_on_gpOrthosteric Liganda2b_on_gp
35.29Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.29Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.29Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
35.29Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.29Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
35.29Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.29Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.29Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
35.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
35.29Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.29Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
35.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
35.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
35.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
35.00Single8WDTphotoNECA8WDT-A2A-photoNECA
35.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
35.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
35.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
35.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
35.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single3D4STimolol3D4S-β2-Timolol
33.33Single3QAKUK-4320973QAK-A2A-UK-432097
33.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
33.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
33.33Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
33.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
33.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
33.33Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
33.33Single5X33BIIL2605X33-BLT1-BIIL260
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6FFIMMPEP6FFI-mGlu5-MMPEP
33.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
33.33Single6PS4ICI118-5516PS4-β2-ICI118-551
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
33.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
33.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
33.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
33.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
33.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
33.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
33.33Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
33.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
33.33Single8JWZAB9288JWZ-A2A-AB928-Na
33.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
33.33Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
33.33Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
33.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
33.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
33.33Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
33.33Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
33.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
33.33Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
33.33Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
33.33Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
33.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
33.33Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
33.33Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensussensory_onOrthosteric Ligandopsins_on
31.82Single5WF5UK-4320975WF5-A2A-UK-432097
31.82Single6PT2KGCHM076PT2-δ-KGCHM07
31.82Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
31.58Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.58Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.58Single5CGDHTL142425CGD-mGlu5-HTL14242
31.58Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
31.58Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
31.58Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
31.58Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
31.58Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
31.58Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
31.58Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
31.58Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.58Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.58Consensusprostanoid_offOrthosteric Ligandep_off dp_off
31.58Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
31.58Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
31.58Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single2Y04Salbutamol2Y04-β1-Salbutamol
31.25Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.25Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
31.25Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.25Single4QKX35V4QKX-β2-35V
31.25Single5DHHSB-6121115DHH-NOP-SB-612111
31.25Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.25Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
31.25Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
31.25Single6FFHFenobam6FFH-mGlu5-Fenobam
31.25Single6H7MSalbutamol6H7M-β1-Salbutamol
31.25Single6PS1Timolol6PS1-β2-Timolol
31.25Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
31.25Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.25Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.25Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
31.25Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.25Single7F83PF-051904577F83-Ghrelin-PF-05190457
31.25Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
31.25Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
31.25Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
31.25Single7WC7Lisuride7WC7-5-HT2A-Lisuride
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
31.25Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.25Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
31.25Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
31.25Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
31.25Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
31.25Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.25Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.25Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.25Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.25Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.25Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
31.25Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.25Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
31.25Single8RLNLUF58348RLN-A2A-LUF5834
31.25Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
31.25Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
31.25Single8X63Mepyramine8X63-H1-Mepyramine
31.25Single8X64Desloratadine8X64-H1-Desloratadine
31.25Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
31.25Single9CHXS-Carazolol9CHX-β2-S-Carazolol
31.25Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
31.25Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.25Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.25Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
31.25Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.25Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.25Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
31.25Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.25Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.25Consensushistamine_offOrthosteric Ligandh1_off
30.77Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.77Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
30.77Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
30.77Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
30.77Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
30.77Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.77Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
30.77Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
30.77Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.77Consensus5ht2_onOrthosteric Ligand5ht2b_on
30.77Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77Consensusgi_sensoryOrthosteric Ligandgi_opsins
30.77Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
30.77Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
30.77Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
30.77Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.77Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
30.43Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
30.00Single3NY9ICI118-5513NY9-β2-ICI118-551
30.00Single5EE7MK08935EE7-Glucagon-MK0893
30.00Single5WF6UK-4320975WF6-A2A-UK-432097
30.00Single6PT3DPI-2876PT3-δ-DPI-287
30.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
30.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
30.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
30.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
30.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
29.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.63Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.63Consensusbombesin_onOrthosteric Ligandbb2_on
29.63Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
29.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
29.41Single2Y03Isoprenaline2Y03-β1-Isoprenaline
29.41Single5JQHS-Carazolol5JQH-β2-S-Carazolol
29.41Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
29.41Single5WIUNemonapride5WIU-D4-Nemonapride
29.41Single5WIVNemonapride5WIV-D4-Nemonapride-Na
29.41Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
29.41Single6LUQHaloperidol6LUQ-D2-Haloperidol
29.41Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
29.41Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
29.41Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
29.41Single7C61Ergotamine7C61-5-HT1B-Ergotamine
29.41Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
29.41Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
29.41Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
29.41Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
29.41Single7WC6LSD7WC6-5-HT2A-LSD
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
29.41Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
29.41Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
29.41Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
29.41Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
29.41Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
29.41Single8S4DCMF-0198S4D-Apelin-CMF-019
29.41Single8TF5Oleic acid8TF5-GPR6-Oleic acid
29.41Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
29.41Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
29.41Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
29.41Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
29.41Single8ZMFA1L108ZMF-5-HT2C-A1L10
29.41Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
29.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
29.41Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
29.41Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
29.41Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
29.41Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
29.41Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
29.41Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
29.41Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
29.41Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
29.41Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
29.41Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.41Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
29.41Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
29.41Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
29.41Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
29.41Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
29.17Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
29.17Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.17Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.17Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
29.17Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
28.57Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
28.57Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
28.57Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
28.57Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
28.57Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
28.57Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
28.57Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7QA8Peptide7QA8-STE2-Peptide
28.57Single7SRQLSD7SRQ-5-HT2B-LSD
28.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
28.57Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
28.57Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
28.57Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
28.57Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
28.57Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
28.57Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Single8KIGSHU91198KIG-MC3-SHU9119-Ca
28.57Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
28.57Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
28.57Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
28.57Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
28.57Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
28.57Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
28.57Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.78Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
27.78Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
27.78Single5V54Methiothepin5V54-5-HT1B-Methiothepin
27.78Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
27.78Single6H7JIsoprenaline6H7J-β1-Isoprenaline
27.78Single6J21Aprepitant6J21-NK1-Aprepitant
27.78Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
27.78Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
27.78Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
27.78Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
27.78Single7P2L4YI7P2L-mGlu5-4YI
27.78Single7TUYGSK682753A7TUY-GPR183-GSK682753A
27.78Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
27.78Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
27.78Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
27.78Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
27.78Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
27.78Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
27.78Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
27.78Single8XVLZibotentan8XVL-ETA-Zibotentan
27.78Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
27.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
27.78Single9BJKNAM9BJK-μ-Naloxone-NAM
27.78Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
27.78Consensus5ht1_offOrthosteric Ligand5ht1b_off
27.78Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
27.78Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.78Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.78Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
27.78Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
27.78Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
27.78Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
27.78Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
27.78Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
27.78Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
27.78Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.78Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
27.27Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
27.27Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.27Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
27.27Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.27Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
27.27Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
26.92Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
26.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
26.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
26.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
26.67Single5U09Taranabant5U09-CB1-Taranabant
26.67Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
26.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
26.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
26.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.67Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
26.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
26.67Single7XRRLemborexant7XRR-OX2-Lemborexant
26.67Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
26.67Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
26.67Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
26.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
26.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
26.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
26.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
26.67Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
26.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
26.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
26.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
26.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
26.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
26.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
26.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
26.32Single4LDEBI1671074LDE-β2-BI167107
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4RWADIPP-NH24RWA-δ-DIPP-NH2
26.32Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
26.32Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
26.32Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
26.32Single6IIURamatroban6IIU-TP-Ramatroban
26.32Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
26.32Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
26.32Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.32Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
26.32Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
26.32Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.32Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.32Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.32Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.32Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
26.32Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
26.32Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
26.32Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.32Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
26.32Single8JJ8Formoterol8JJ8-β2-Formoterol
26.32Single8JWY2-1188JWY-A2A-2-118
26.32Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
26.32Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.32Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.32Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
26.32Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.32Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.32Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.32Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
26.32Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
26.32Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
26.32Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
26.32Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
26.32Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.32Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuslpl_offOrthosteric Ligands1p_off lpa_off
26.32Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
26.32Consensusorexin_onOrthosteric Ligandox2_on
26.32Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.09Single6W25SHU91196W25-MC4-SHU9119-Ca
26.09Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
26.09Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.09Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.09Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.09Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
26.09Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
26.09Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
25.93Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
25.00Single3RZECidoxepin3RZE-H1-Cidoxepin
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6A94Zotepine6A94-5-HT2A-Zotepine
25.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
25.00Single6H7LDobutamine6H7L-β1-Dobutamine
25.00Single6IBLArformoterol6IBL-β1-Arformoterol
25.00Single6IQLL7458706IQL-D4-L745870
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6TPNHTL66416TPN-OX2-HTL6641
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
25.00Single7EZCUKA7EZC-A2A-UKA
25.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
25.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
25.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
25.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
25.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
25.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
25.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
25.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
25.00Single8K2WAMG4878K2W-CXCR3-AMG487
25.00Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
25.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
25.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
25.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
25.00Single8XVJMacitentan8XVJ-ETA-Macitentan
25.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
25.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
25.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
25.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
25.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
25.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
25.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
25.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
25.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
25.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensussensory_offOrthosteric Ligandopsins_off
25.00Consensusvasop-oxy_offOrthosteric Ligandot_off
24.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
24.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
24.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
24.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
23.81Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
23.81Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7XN9L-054,5227XN9-SST2-L-054,522
23.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
23.81Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
23.81Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
23.81Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.81Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
23.81Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
23.81Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.53Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
23.53Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
23.53Single2Y01Dobutamine2Y01-β1-Dobutamine
23.53Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.53Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
23.53Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
23.53Single5DHGC-355DHG-NOP-C-35
23.53Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.53Single6GPSMK08126GPS-CCR2-MK0812
23.53Single6IIVDaltroban6IIV-TP-Daltroban
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
23.53Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.53Single7BU7BI1671077BU7-β1-BI167107
23.53Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
23.53Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
23.53Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
23.53Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
23.53Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
23.53Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.53Single7V3ZCP559407V3Z-CB1-CP55940
23.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.53Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
23.53Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.53Single7YXAONO-54306087YXA-S1P5-ONO-5430608
23.53Single8CU6LJ-45178CU6-A2A-LJ-4517
23.53Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
23.53Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
23.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.53Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
23.53Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
23.53Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
23.53Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
23.53Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
23.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
23.53Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
23.53Single9B9ZA1AKO9B9Z-CB1-A1AKO
23.53Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.53Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.53Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.53Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.53Consensusa3_onOrthosteric Liganda3a_on
23.53Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
23.53Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
23.53Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
23.08Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
23.08Single3OE8IT1t3OE8-CXCR4-IT1t
23.08Single6FJ3PTH6FJ3-PTH1-PTH
23.08Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.08Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
23.08Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.08Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.08Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.08Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
23.08Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.08Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
23.08Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
22.73Single4IARErgotamine4IAR-5-HT1B-Ergotamine
22.73Single4XT1Fractalkine4XT1-US28-Fractalkine
22.73Single7F8XNN90567F8X-CCKA-NN9056
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.73Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
22.73Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
22.73Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
22.73Single8WKYPG-9348WKY-MC4-PG-934
22.73Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.73Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.22Single2Y00Dobutamine2Y00-β1-Dobutamine
22.22Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
22.22Single5N2RPSB-365N2R-A2A-PSB-36-Na
22.22Single5N2SPSB365N2S-A1-PSB36
22.22Single5TVNLSD5TVN-5-HT2B-LSD
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single6D26Fevipiprant6D26-DP2-Fevipiprant
22.22Single6E67BI1671076E67-β2-BI167107-Gs (fused)
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6HLPNetupitant6HLP-NK1-Netupitant
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
22.22Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
22.22Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.22Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
22.22Single7W41PD1762527W41-BB2-PD176252
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
22.22Single8JXSPF-61428JXS-D1-PF-6142
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.22Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
22.22Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
22.22Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.22Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
22.22Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
22.22Consensusa3_on_gpOrthosteric Liganda3a_on_gp
22.22Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.22Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.22Consensusbombesin_offOrthosteric Ligandbb2_off
22.22Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.22Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
22.22Consensusdp_offOrthosteric Liganddp2_off
22.22Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.22Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.22Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
22.22Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
22.22Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
21.74Single6HLOAprepitant6HLO-NK1-Aprepitant
21.74Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
21.74Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
21.74Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
21.74Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
21.74Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
21.74Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.74Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.74Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.74Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.74Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.43Single3OE6IT1t3OE6-CXCR4-IT1t
21.43Single3UZAGTPL92363UZA-A2A-GTPL9236
21.43Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
21.43Single6IGLIRL16206IGL-ETB-IRL1620
21.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
21.43Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
21.43Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
21.43Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
21.43Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.43Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.43Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
21.43Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
21.43Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.43Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.43Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusbradykinin_onOrthosteric Ligandbk2_on
21.43Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
21.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.05Single3P0GBI1671073P0G-β2-BI167107
21.05Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
21.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.05Single5XR8AM8415XR8-CB1-AM841
21.05Single5XRAAM115425XRA-CB1-AM11542
21.05Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
21.05Single6E59L-7607356E59-NK1-L-760735
21.05Single6J20Aprepitant6J20-NK1-Aprepitant
21.05Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single6WGTLSD6WGT-5-HT2A-LSD
21.05Single7B6WCyclazosin7B6W-α1b-Cyclazosin
21.05Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
21.05Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
21.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
21.05Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.05Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
21.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
21.05Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
21.05Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
21.05Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
21.05Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.05Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
21.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
21.05Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
21.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
21.05Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
21.05Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.05Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
21.05Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
21.05Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
21.05Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.05Consensustachykinin_offOrthosteric Ligandnk1_off
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
20.83Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.83Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.83Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.83Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Consensusangiotensin_onOrthosteric Ligandat1_on
20.83Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.83Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.83Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.83Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
20.69Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
20.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3PBLEticlopride3PBL-D3-Eticlopride
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
20.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
20.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6MXTSalmeterol6MXT-β2-Salmeterol
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
20.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
20.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
20.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
20.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
20.00Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
20.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
20.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.00Single8JJLOlodaterol8JJL-β2-Olodaterol
20.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
20.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.00Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
20.00Single9B9Y7DY9B9Y-CB1-7DY
20.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
20.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
20.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
20.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
20.00Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
20.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
20.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
19.23Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
19.23Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
19.23Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
19.23Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
19.23Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
19.23Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
19.23Single8ZRTET-18ZRT-ETB-ET-1
19.23Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
19.23Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.23Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
19.23Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
19.05Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
19.05Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.05Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
19.05Single6K1QIRL25006K1Q-ETB-IRL2500
19.05Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
19.05Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
19.05Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
19.05Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
19.05Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
19.05Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
19.05Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
19.05Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
19.05Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
19.05Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Consensuscck_onOrthosteric Ligandccka_on cckb_on
19.05Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
18.75Single3ODUIT1t3ODU-CXCR4-IT1t
18.75Single3PWHZM-2413853PWH-A2A-ZM-241385
18.75Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.75Single6DS0Ly2660976DS0-5-HT2B-Ly266097
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.75Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
18.75Single7F8ULintitript7F8U-CCKA-Lintitript
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
18.75Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
18.75Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
18.75Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
18.75Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
18.75Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
18.75Single8GNGIstradefylline8GNG-A2A-Istradefylline
18.75Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
18.75Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
18.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
18.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.75Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
18.75Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.75Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
18.52Single4XT3Fractalkine4XT3-US28-Fractalkine
18.52Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
18.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
18.52Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
18.52Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
18.52Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
18.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
18.52Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
18.52Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
18.18Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.18Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
18.18Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
18.18Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
18.18Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
18.18Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
18.18Single8QJ2pN1628QJ2-MC4-pN162-Gs
18.18Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.86Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
17.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.86Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.86Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
17.86Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.86Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
17.86Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
17.86Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.65Single3REYXAC3REY-A2A-XAC
17.65Single5IU7Q274563465IU7-A2A-Q27456346-Na
17.65Single5JTBZM-2413855JTB-A2A-ZM-241385
17.65Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
17.65Single6AQFZM-2413856AQF-A2A-ZM-241385
17.65Single6MH8ZM-2413856MH8-A2A-ZM-241385
17.65Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
17.65Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
17.65Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
17.65Single7AROLUF58337ARO-A2A-LUF5833-Na
17.65Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
17.65Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
17.65Single7T32ZM-2413857T32-A2A-ZM-241385
17.65Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
17.65Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.65Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
17.65Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
17.65Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
17.65Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
17.65Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
17.65Consensusa2_offOrthosteric Liganda2a_off
17.65Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
17.65Consensusgrh_offOrthosteric Ligandgnrh1_off
17.65Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.65Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.39Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
17.39Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
17.39Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
17.39Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
17.39Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.39Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
17.39Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
17.39Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
17.39Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.39Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.39Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
17.39Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.24Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
17.24Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
17.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
17.24Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
17.24Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.24Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.24Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.67Single2Y02Carmoterol2Y02-β1-Carmoterol
16.67Single3EMLZM-2413853EML-A2A-ZM-241385
16.67Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
16.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
16.67Single5IU8Q274563475IU8-A2A-Q27456347-Na
16.67Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
16.67Single5UENDU1725UEN-A1-DU172
16.67Single5UIGCmpd-15UIG-A2A-Cmpd-1
16.67Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
16.67Single6D27CAY104716D27-DP2-CAY10471
16.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
16.67Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.67Single6S0LZM-2413856S0L-A2A-ZM-241385
16.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
16.67Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.67Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
16.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67Single7PYRPSB-21157PYR-A2A-PSB-2115
16.67Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
16.67Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
16.67Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
16.67Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
16.67Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
16.67Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.67Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
16.67Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.67Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
16.67Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.67Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
16.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
16.67Consensuscck_offOrthosteric Ligandccka_off
16.67Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
16.67Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.67Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.67Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
16.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
16.22Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
16.13Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
16.13Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
16.13Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
16.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
16.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
16.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
16.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
16.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
16.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
16.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
16.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
16.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.79Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
15.79Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.79Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.79Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.79Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.79Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
15.79Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.79Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.79Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.79Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
15.79Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
15.79Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
15.79Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.62Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
15.62Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
15.38Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
15.38Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.38Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
15.38Single7WC4Serotonin7WC4-5-HT2A-Serotonin
15.38Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
15.38Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8PWNTheophylline8PWN-A2A-Theophylline
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.38Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.38Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
15.38Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
15.38Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
15.38Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
15.15Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
15.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
15.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
15.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
15.00Single7PX4PSB-21137PX4-A2A-PSB-2113
15.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
15.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
15.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
15.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
15.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
15.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
15.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
15.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
14.81Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
14.81Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.81Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Single3RFMCaffeine3RFM-A2A-Caffeine
14.29Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6TQ9SB-4081246TQ9-OX1-SB-408124
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
14.29Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
14.29Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.29Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
14.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
14.29Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
14.29Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
14.29Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
14.29Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.29Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
14.29Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.89Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
13.79Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.79Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.79Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
13.79Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
13.64Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
13.64Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.64Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
13.64Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
13.64Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.64Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.64Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.64Consensuschemerin_onOrthosteric Ligandcml1_on
13.64Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
13.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
13.33Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
13.33Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
13.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.33Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.33Single7WC5Psilocin7WC5-5-HT2A-Psilocin
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
13.33Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.33Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.04Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.04Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
13.04Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
13.04Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.04Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.04Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
13.04Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.04Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
13.04Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.90Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.90Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.90Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.50Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.50Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single6HLLCP999946HLL-NK1-CP99994
12.50Single6LI0C176LI0-GPR52-C17
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
12.50Single6TP4ACT-4622066TP4-OX1-ACT-462206
12.50Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
12.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.50Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
12.50Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
12.50Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
12.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.50Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
12.50Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
12.50Single8IEBA1LYA8IEB-GPR156-A1LYA
12.50Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.50Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
12.50Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
12.50Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
12.50Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
12.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.50Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.50Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
12.50Consensussomatostatin_offOrthosteric Ligandsst2_off
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.00Single7SK5CXCL127SK5-ACKR3-CXCL12
12.00Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
12.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
12.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.76Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
11.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
11.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
11.76Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
11.76Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.76Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
11.76Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
11.76Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
11.76Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
11.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.76Single6ME2Ramelteon6ME2-MT1-Ramelteon
11.76Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.76Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.76Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
11.76Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.76Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.76Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
11.76Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
11.76Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
11.76Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
11.76Single9BA0A1AKN9BA0-CB1-A1AKN
11.76Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
11.54Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
11.54Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
11.54Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
11.54Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
11.54Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
11.54Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
11.11Single5IUBQ274563445IUB-A2A-Q27456344-Na
11.11Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
11.11Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
11.11Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
11.11Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.11Single5UVIZM-2413855UVI-A2A-ZM-241385
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.11Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.11Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
11.11Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
11.11Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
11.11Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
11.11Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.11Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
11.11Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.11Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.71Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.71Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.71Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
10.71Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
10.53Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
10.53Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.53Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.53Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.53Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
10.53Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.53Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.53Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
10.53Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.53Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
10.53Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
10.34Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.34Single7SK3CXCL127SK3-ACKR3-CXCL12
10.34Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.34Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
10.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
10.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
10.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.00Single8QOTNanobody-E8QOT-μ-Nanobody-E
10.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.68Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.68Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
9.52Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.52Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
9.52Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
9.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
9.52Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.52Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
9.52Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
9.52Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.52Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.52Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.38Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
9.09Single6OS2TRV0266OS2-AT1-TRV026
9.09Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.09Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
9.09Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
9.09Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.09Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
8.70Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.70Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.70Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.33Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.33Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.33Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.00Single8IEIA1LYA8IEI-GPR156-A1LYA
8.00Single8IEPA1LYA8IEP-GPR156-A1LYA
8.00Single8IEPA1LYA8IEP-GPR156-A1LYA
8.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.00Single8XWNCXCL88XWN-CXCR2-CXCL8
8.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.69Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.69Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8IEBA1LYA8IEB-GPR156-A1LYA
7.69Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
7.69Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.69Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.41Single3OE0CVX153OE0-CXCR4-CVX15
7.41Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
7.41Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.41Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.41Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.14Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
7.14Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
7.14Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
7.14Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.14Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
6.90Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
6.90Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.90Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
6.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
6.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.25Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.25Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.25Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
6.25Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.25Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
5.88Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.88Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.88Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.88Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.88Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.56Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.56Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.56Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.56Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.56Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
5.56Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.56Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.56Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.56Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.26Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
5.26Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.26Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.26Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Single4QIMANTA XV4QIM-SMO-ANTA XV
5.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.00Single5T04Neurotensin5T04-NTS1-Neurotensin
5.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
5.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
5.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.76Single4JKVTaladegib4JKV-SMO-Taladegib
4.76Single4NTJAZD12834NTJ-P2Y12-AZD1283
4.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
4.76Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
4.76Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
4.76Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.76Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.76Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.76Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.55Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.55Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.55Single5TZRMK86665TZR-FFA1-MK8666
4.55Single5V56TC1145V56-SMO-TC114
4.55Single5V57TC1145V57-SMO-TC114
4.55Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
4.55Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.55Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.55Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.55Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
4.55Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
4.55Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
4.55Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
4.55Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
4.55Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.55Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
4.55Consensuslpa_onOrthosteric Ligandlpa1_on
4.55Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
4.55Consensusneurotensin_onOrthosteric Ligandnts1_on
4.55Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.35Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.35Single4XESNeurotensin4XES-NTS1-Neurotensin
4.35Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
4.35Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.35Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
4.35Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.35Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
4.35Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.35Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.35Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.17Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
4.17Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.17Single8XVUCXCL28XVU-CXCR2-CXCL2
4.17Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
4.17Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
4.17Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
4.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
4.00Single8XQJJN2418XQJ-Apelin-JN241
4.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
4.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
3.85Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.85Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
3.85Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.85Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 8HNM
Class A
SubFamily Protein
Type Chemokine
SubType CXCR3
Species Homo Sapiens
Ligand VUF11222
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.94
Date 2023-11-29
D.O.I. 10.1038/s41594-023-01175-5
Net Summary
Imin 2.94
Number of Linked Nodes 823
Number of Links 1016
Number of Hubs 162
Number of Links mediated by Hubs 603
Number of Communities 32
Number of Nodes involved in Communities 223
Number of Links involved in Communities 314
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 3552563
Length Of Smallest Path 3
Average Path Length 37.0477
Length of Longest Path 62
Minimum Path Strength 1.435
Average Path Strength 5.72473
Maximum Path Strength 22.26
Minimum Path Correlation 0.71
Average Path Correlation 0.991071
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 33.8583
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.4383
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • chemokine binding   • cytokine binding   • C-X-C chemokine receptor activity   • C-C chemokine binding   • C-X-C chemokine binding   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • oxidoreductase activity   • monooxygenase activity   • Oplophorus-luciferin 2-monooxygenase activity   • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)   • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen   • luciferin monooxygenase activity   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell adhesion   • regulation of cell adhesion   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • blood vessel development   • immune response   • immune system process   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of biological process   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • taxis   • regulation of response to stimulus   • regulation of locomotion   • locomotion   • apoptotic process   • cell death   • programmed cell death   • calcium-mediated signaling   • positive regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • positive regulation of apoptotic process   • regulation of execution phase of apoptosis   • positive regulation of execution phase of apoptosis   • execution phase of apoptosis   • positive regulation of cellular process   • negative regulation of programmed cell death   • negative regulation of biological process   • negative regulation of execution phase of apoptosis   • negative regulation of apoptotic process   • negative regulation of cellular process   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • cell chemotaxis   • cell migration   • cell motility   • cell surface receptor signaling pathway   • regulation of developmental process   • regulation of vasculature development   • positive regulation of developmental process   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • positive regulation of angiogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • positive regulation of multicellular organismal process   • regulation of calcium ion transport   • regulation of localization   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • intracellular calcium ion homeostasis   • calcium ion transport   • localization   • positive regulation of monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation homeostasis   • monoatomic cation transport   • intracellular monoatomic ion homeostasis   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • establishment of localization   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • chemical homeostasis   • cellular localization   • inorganic ion homeostasis   • transport   • homeostatic process   • monoatomic ion transmembrane transport   • calcium ion homeostasis   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • maintenance of location in cell   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • intracellular chemical homeostasis   • positive regulation of release of sequestered calcium ion into cytosol   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • calcium ion transmembrane import into cytosol   • regulation of transport   • sequestering of calcium ion   • cellular homeostasis   • positive regulation of transport   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • defense response   • response to stress   • inflammatory response   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • negative regulation of multicellular organismal process   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • regulation of cell motility   • regulation of leukocyte migration   • leukocyte migration   • regulation of cell migration   • regulation of immune system process   • negative regulation of cell population proliferation   • endothelial cell proliferation   • negative regulation of endothelial cell proliferation   • regulation of endothelial cell proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • negative regulation of epithelial cell proliferation   • electron transport chain   • generation of precursor metabolites and energy   • bioluminescence   • cell surface   • external side of plasma membrane   • periplasmic space
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code4IE
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code4IE
Name[4-(2-bromophenyl)phenyl]methyl-[[(1R,5S)-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl]-dimethyl-azanium
SynonymsVUF11222
Identifier
FormulaC25 H31 Br N
Molecular Weight425.424
SMILES
PubChem71459295
Formal Charge1
Total Atoms58
Total Chiral Atoms2
Total Bonds61
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HNM_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKIVKT TGIVETHFT FKDLHFKMF DVGAQRSER KKWIHCFEG 
VTAIIFCVA LSDEMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC STDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HNM_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HNM_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49682
Sequence
>8HNM_Chain_R
YSLLFLLGL LGNGAVAAV LLSRRTALS STDTFLLHL AVADTLLVL 
TLPLWAVDA AVQWVFGSG LCKVAGALF NINFYAGAL LLACISFDR 
YLNIVHATQ LYRRGPPAR VTLTCLAVW GLCLLFALP DFIFLSAHH 
DERLNATHC QYNFPQVGR TALRVLQLV AGFLLPLLV MAYCYAHIL 
AVLLVSRGQ RRLRAMRLV VVVVVAFAL CWTPYHLVV LVDILMDLG 
ALARNCGRE SRVDVAKSV TSGLGYMHC CLNPLLYAF VGVKFRERM 
WMLLLRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K2WAProteinChemokineCXCR3Homo sapiensAMG487--32023-11-2910.1038/s41594-023-01175-5
8HNNAProteinChemokineCXCR3Homo sapiensSCH546738--3.62023-11-2910.1038/s41594-023-01175-5
8K2XAProteinChemokineCXCR3Homo sapiensCXCL10-Gi1/β1/γ23.22023-11-2910.1038/s41594-023-01175-5
8K2X (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL10-3.22023-11-2910.1038/s41594-023-01175-5
8HNMAProteinChemokineCXCR3Homo sapiensVUF11222-Gi1/β1/γ22.942023-11-2910.1038/s41594-023-01175-5
8HNM (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11222-2.942023-11-2910.1038/s41594-023-01175-5
8HNLAProteinChemokineCXCR3Homo sapiensPS372424-Gi1/β1/γ22.982023-11-2910.1038/s41594-023-01175-5
8HNL (No Gprot) AProteinChemokineCXCR3Homo sapiensPS372424-2.982023-11-2910.1038/s41594-023-01175-5
8HNKAProteinChemokineCXCR3Homo sapiensCXCL11-Gi1/β1/γ23.012023-11-2910.1038/s41594-023-01175-5
8HNK (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL11-3.012023-11-2910.1038/s41594-023-01175-5
8Y0HAProteinChemokineCXCR3Homo sapiensVUF11418--3.532025-02-26To be published
8XYIAProteinChemokineCXCR3Homo sapiensVUF10661--3.162025-02-26To be published
8XXYAProteinChemokineCXCR3Homo sapiens---3.682025-02-26To be published
8Y0NAProteinChemokineCXCR3Homo sapiensVUF11418-Go1/β1/γ23.072025-02-26To be published
8Y0N (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11418-3.072025-02-26To be published
8XYKAProteinChemokineCXCR3Homo sapiensVUF10661-Go1/β1/γ23.032025-02-26To be published
8XYK (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF10661-3.032025-02-26To be published
8XXZAProteinChemokineCXCR3Homo sapiens--Go1/β1/γ23.32025-02-26To be published
8XXZ (No Gprot) AProteinChemokineCXCR3Homo sapiens--3.32025-02-26To be published




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Download 8HNM.zip



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