psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L59	R:R:Y60	9.38	No	Yes	0	6	8
2	R:R:L106	R:R:Y60	2.34	Yes	Yes	0	8	8
3	R:R:W109	R:R:Y60	4.82	Yes	Yes	0	5	8
4	R:R:A110	R:R:Y60	4	No	Yes	0	7	8
5	R:R:L65	R:R:S61	3	No	No	0	5	6
6	R:R:L62	R:R:L66	4.15	No	No	0	5	6
7	R:R:C312	R:R:L63	3.17	Yes	No	0	8	7
8	R:R:F64	R:R:L68	10.96	No	No	0	7	6
9	R:R:F64	R:R:L106	3.65	No	Yes	1	7	8
10	R:R:F64	R:R:P107	4.33	No	No	1	7	9
11	R:R:L68	R:R:V103	2.98	No	No	0	6	6
12	R:R:G70	R:R:P315	4.06	No	No	0	7	9
13	R:R:D99	R:R:N71	5.39	Yes	Yes	0	9	9
14	R:R:N71	R:R:T100	5.85	Yes	No	0	9	7
15	R:R:N71	R:R:P315	11.4	Yes	No	0	9	9
16	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
17	R:R:A319	R:R:V74	3.39	No	Yes	3	7	9
18	R:R:F320	R:R:V74	2.62	No	Yes	3	7	9
19	R:R:F325	R:R:V74	7.87	Yes	Yes	3	8	9
20	R:R:F325	R:R:V77	7.87	Yes	No	0	8	7
21	R:R:M329	R:R:V77	3.04	No	No	0	6	7
22	R:R:L332	R:R:V77	2.98	No	No	0	5	7
23	R:R:L78	R:R:L85	4.15	No	No	0	7	6
24	R:R:L78	R:R:L92	4.15	No	No	0	7	8
25	R:R:L78	R:R:L93	6.92	No	Yes	0	7	6
26	R:R:L79	R:R:L93	4.15	No	Yes	0	4	6
27	R:R:L332	R:R:S80	9.01	No	No	0	5	5
28	R:R:R81	R:R:T83	12.94	No	No	0	5	6
29	R:R:L85	R:R:R81	2.43	No	No	0	6	5
30	R:R:R328	R:R:R81	17.06	No	No	0	5	5
31	R:R:R335	R:R:R82	9.6	No	No	0	4	5
32	R:R:A84	R:R:P165	3.74	No	No	0	7	2
33	R:R:D89	R:R:L85	8.14	Yes	No	0	8	6
34	R:R:D89	R:R:S86	5.89	Yes	No	0	8	7
35	R:R:D148	R:R:S87	5.89	No	No	0	8	6
36	R:R:D148	R:R:T88	7.23	No	No	0	8	8
37	R:R:R149	R:R:T88	2.59	Yes	No	0	9	8
38	R:R:D89	R:R:K324	5.53	Yes	No	4	8	6
39	R:R:D89	R:R:R328	3.57	Yes	No	4	8	5
40	R:R:H94	R:R:T90	2.74	Yes	No	0	9	6
41	R:R:T90	R:R:V168	4.76	No	No	0	6	8
42	R:R:C144	R:R:F91	5.59	No	Yes	0	7	7
43	R:R:F91	R:R:I145	3.77	Yes	No	1	7	9
44	R:R:F91	R:R:V168	7.87	Yes	No	1	7	8
45	R:R:F91	R:R:T171	3.89	Yes	No	1	7	5
46	R:R:C172	R:R:F91	2.79	No	Yes	0	7	7
47	R:R:A319	R:R:L92	4.73	No	No	0	7	8
48	R:R:H94	R:R:L141	2.57	Yes	No	0	9	8
49	R:R:C172	R:R:H94	11.79	No	Yes	0	7	9
50	R:R:H94	R:R:W176	7.41	Yes	Yes	0	9	9
51	R:R:D99	R:R:L95	9.5	Yes	Yes	1	9	9
52	R:R:L141	R:R:L95	4.15	No	Yes	0	8	9
53	R:R:L142	R:R:L95	5.54	Yes	Yes	1	8	9
54	R:R:L95	R:R:N314	6.87	Yes	Yes	1	9	9
55	R:R:A98	R:R:W176	2.59	No	Yes	0	8	9
56	R:R:C311	R:R:D99	6.22	No	Yes	0	8	9
57	R:R:D99	R:R:N314	6.73	Yes	Yes	1	9	9
58	R:R:L101	R:R:L130	2.77	No	No	5	5	5
59	R:R:L101	R:R:N134	10.98	No	Yes	5	5	8
60	R:R:F131	R:R:L102	9.74	Yes	No	0	5	6
61	R:R:L102	R:R:N134	6.87	No	Yes	0	6	8
62	R:R:C311	R:R:V103	3.42	No	No	0	8	6
63	R:R:F131	R:R:T105	2.59	Yes	No	0	5	7
64	R:R:L106	R:R:P107	4.93	Yes	No	1	8	9
65	R:R:L106	R:R:Y308	11.72	Yes	No	1	8	6
66	R:R:A113	R:R:W109	2.59	No	Yes	0	5	5
67	R:R:S304	R:R:W109	8.65	No	Yes	1	5	5
68	L:L:?1	R:R:W109	2.57	Yes	Yes	1	0	5
69	R:R:F119	R:R:V111	3.93	Yes	No	0	7	4
70	R:R:D112	R:R:W117	8.93	No	Yes	0	5	9
71	R:R:D112	R:R:H202	3.78	No	No	0	5	3
72	R:R:Q116	R:R:V115	5.73	No	No	0	3	4
73	R:R:Q116	R:R:V118	4.3	No	No	0	3	3
74	R:R:Q116	R:R:T201	4.25	No	No	0	3	5
75	R:R:F119	R:R:W117	14.03	Yes	Yes	2	7	9
76	R:R:G120	R:R:W117	2.81	No	Yes	0	8	9
77	R:R:L123	R:R:W117	5.69	No	Yes	2	6	9
78	R:R:C124	R:R:W117	13.06	No	Yes	2	9	9
79	R:R:C203	R:R:W117	2.61	No	Yes	2	9	9
80	R:R:F119	R:R:V118	5.24	Yes	No	0	7	3
81	R:R:F119	R:R:L123	8.53	Yes	No	2	7	6
82	R:R:G122	R:R:S121	3.71	No	No	0	1	3
83	R:R:K125	R:R:S121	4.59	No	No	0	7	3
84	R:R:C124	R:R:C203	7.28	No	No	2	9	9
85	R:R:A129	R:R:F187	8.32	No	No	0	5	4
86	R:R:L130	R:R:N134	5.49	No	Yes	5	5	8
87	R:R:F131	R:R:F135	4.29	Yes	Yes	1	5	7
88	R:R:F131	R:R:Y308	6.19	Yes	No	1	5	6
89	L:L:?1	R:R:F131	20.64	Yes	Yes	1	0	5
90	R:R:D186	R:R:N132	12.12	No	No	0	4	4
91	R:R:I133	R:R:W176	2.35	Yes	Yes	0	6	9
92	R:R:I133	R:R:L180	4.28	Yes	No	0	6	4
93	R:R:A183	R:R:I133	3.25	No	Yes	0	7	6
94	R:R:N134	R:R:W176	2.26	Yes	Yes	0	8	9
95	R:R:F135	R:R:W268	8.02	Yes	Yes	1	7	9
96	R:R:F135	R:R:H272	2.26	Yes	Yes	1	7	8
97	L:L:?1	R:R:F135	6.19	Yes	Yes	1	0	7
98	R:R:C179	R:R:Y136	2.69	No	No	0	8	6
99	R:R:F182	R:R:Y136	8.25	Yes	No	0	5	6
100	R:R:Q219	R:R:Y136	4.51	No	No	0	5	6
101	R:R:A137	R:R:W176	5.19	No	Yes	0	7	9
102	R:R:A139	R:R:W268	2.59	No	Yes	0	8	9
103	R:R:L140	R:R:V175	4.47	No	No	0	6	7
104	R:R:L142	R:R:M231	4.24	Yes	Yes	1	8	8
105	R:R:F264	R:R:L142	2.44	Yes	Yes	1	9	8
106	R:R:L142	R:R:N314	4.12	Yes	Yes	1	8	9
107	R:R:L142	R:R:Y318	5.86	Yes	Yes	1	8	9
108	R:R:A143	R:R:V230	3.39	No	No	0	7	7
109	R:R:I145	R:R:R149	6.26	No	Yes	1	9	9
110	R:R:I145	R:R:Y318	6.04	No	Yes	1	9	9
111	R:R:M231	R:R:S146	6.13	Yes	No	1	8	9
112	R:R:S146	R:R:Y235	12.72	No	Yes	1	9	8
113	R:R:F147	R:R:Y150	2.06	No	Yes	1	6	8
114	R:R:F147	R:R:L151	8.53	No	No	1	6	5
115	R:R:C234	R:R:F147	2.79	No	No	1	7	6
116	R:R:D148	R:R:N152	5.39	No	No	0	8	8
117	R:R:R149	R:R:Y235	4.12	Yes	Yes	1	9	8
118	R:R:R149	R:R:Y318	7.2	Yes	Yes	1	9	9
119	R:R:L151	R:R:Y150	3.52	No	Yes	1	5	8
120	R:R:V154	R:R:Y150	12.62	No	Yes	1	7	8
121	R:R:H155	R:R:Y150	6.53	No	Yes	1	6	8
122	R:R:C234	R:R:Y150	5.38	No	Yes	1	7	8
123	R:R:H237	R:R:Y150	4.36	No	Yes	0	4	8
124	R:R:L151	R:R:L159	5.54	No	No	0	5	6
125	R:R:I153	R:R:I238	5.89	No	No	0	8	8
126	R:R:H155	R:R:V154	5.54	No	No	1	6	7
127	R:R:V154	R:R:V241	6.41	No	No	0	7	5
128	R:R:H155	R:R:Q158	7.42	No	No	0	6	4
129	R:R:P164	R:R:R161	10.09	No	No	0	6	4
130	R:R:G163	R:R:P164	4.06	No	No	0	6	6
131	R:R:R167	R:R:T169	5.17	No	No	0	4	4
132	R:R:T171	R:R:V168	4.76	No	No	1	5	8
133	R:R:L173	R:R:T169	4.42	No	No	0	5	4
134	R:R:F182	R:R:L178	7.31	Yes	No	0	5	4
135	R:R:F182	R:R:L218	4.87	Yes	No	0	5	3
136	R:R:F189	R:R:P185	2.89	Yes	No	0	5	7
137	R:R:D186	R:R:Y205	2.3	No	Yes	0	4	3
138	R:R:F189	R:R:I188	13.82	Yes	No	0	5	4
139	R:R:F189	R:R:N206	3.62	Yes	No	0	5	4
140	R:R:F189	R:R:F207	24.65	Yes	No	0	5	4
141	R:R:C203	R:R:L190	3.17	No	No	0	9	5
142	R:R:L190	R:R:Y205	7.03	No	Yes	0	5	3
143	R:R:D195	R:R:H193	11.35	No	No	6	2	3
144	R:R:H193	R:R:Q204	12.36	No	No	6	3	3
145	R:R:D195	R:R:Q204	5.22	No	No	6	2	3
146	R:R:L198	R:R:R197	13.36	No	No	0	1	4
147	R:R:E293	R:R:R197	22.1	No	No	0	1	4
148	R:R:H202	R:R:L198	2.57	No	No	0	3	1
149	R:R:A200	R:R:H202	4.39	No	No	0	1	3
150	R:R:Q204	R:R:R212	8.18	No	No	0	3	4
151	R:R:R212	R:R:Y205	2.06	No	Yes	0	4	3
152	R:R:L215	R:R:Y205	4.69	No	Yes	0	5	3
153	R:R:F207	R:R:P208	4.33	No	No	0	4	4
154	R:R:Q209	R:R:R288	4.67	No	No	0	2	4
155	R:R:R212	R:R:R216	2.13	No	No	0	4	3
156	R:R:L283	R:R:T213	2.95	No	No	0	1	1
157	R:R:D278	R:R:R216	4.76	No	No	0	5	3
158	R:R:I279	R:R:R216	3.76	No	No	0	5	3
159	R:R:I279	R:R:V217	3.07	No	No	0	5	4
160	R:R:H272	R:R:L220	3.86	Yes	No	0	8	4
161	R:R:L220	R:R:L276	2.77	No	No	0	4	5
162	R:R:L225	R:R:V221	4.47	No	No	0	4	5
163	R:R:G223	R:R:P227	4.06	No	No	0	5	9
164	R:R:F224	R:R:L228	4.87	Yes	No	0	8	7
165	R:R:F224	R:R:W268	3.01	Yes	Yes	1	8	9
166	R:R:F224	R:R:T269	5.19	Yes	No	0	8	5
167	R:R:F224	R:R:H272	22.63	Yes	Yes	1	8	8
168	R:R:L226	R:R:P227	6.57	No	No	0	6	9
169	R:R:F264	R:R:L228	3.65	Yes	No	0	9	7
170	R:R:M231	R:R:Y235	2.39	Yes	Yes	1	8	8
171	R:R:F264	R:R:M231	11.2	Yes	Yes	1	9	8
172	R:R:H237	R:R:Y233	10.89	No	No	0	4	4
173	R:R:I238	R:R:Y235	2.42	No	Yes	0	8	8
174	R:R:V257	R:R:Y235	10.09	No	Yes	0	7	8
175	R:R:V260	R:R:Y235	3.79	No	Yes	1	8	8
176	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
177	R:R:Y235	R:R:Y318	4.96	Yes	Yes	1	8	9
178	R:R:I238	R:R:L242	2.85	No	No	0	8	8
179	R:R:L239	R:R:V257	4.47	No	No	0	5	7
180	R:R:L239	R:R:V258	4.47	No	No	0	5	5
181	R:R:A253	R:R:L242	3.15	No	No	0	7	8
182	R:R:L242	R:R:M254	4.24	No	No	0	8	6
183	R:R:L243	R:R:M254	7.07	No	No	0	4	6
184	R:R:R250	R:R:S245	9.22	Yes	No	0	6	4
185	R:R:L251	R:R:R250	3.64	No	Yes	0	5	6
186	R:R:M254	R:R:R250	7.44	No	Yes	0	6	6
187	R:R:L256	R:R:V321	8.94	No	No	0	8	7
188	R:R:V260	R:R:Y318	3.79	No	Yes	1	8	9
189	R:R:L266	R:R:V262	2.98	No	No	0	5	5
190	R:R:F264	R:R:W268	21.05	Yes	Yes	1	9	9
191	R:R:C267	R:R:H310	7.37	No	No	0	9	9
192	R:R:H272	R:R:W268	4.23	Yes	Yes	1	8	9
193	R:R:H310	R:R:W268	9.52	No	Yes	0	9	9
194	L:L:?1	R:R:W268	4.5	Yes	Yes	1	0	9
195	R:R:P270	R:R:T269	3.5	No	No	0	9	5
196	R:R:P270	R:R:T303	3.5	No	No	0	9	7
197	R:R:H272	R:R:Y271	7.62	Yes	Yes	1	8	6
198	R:R:V275	R:R:Y271	5.05	No	Yes	0	5	6
199	R:R:T303	R:R:Y271	4.99	No	Yes	0	7	6
200	R:R:S304	R:R:Y271	2.54	No	Yes	1	5	6
201	L:L:?1	R:R:Y271	17.88	Yes	Yes	1	0	6
202	R:R:A299	R:R:V274	3.39	No	Yes	0	5	4
203	R:R:K300	R:R:V274	4.55	No	Yes	0	5	4
204	R:R:T303	R:R:V274	3.17	No	Yes	0	7	4
205	R:R:L276	R:R:L280	2.77	No	No	0	5	4
206	R:R:D278	R:R:D282	11.98	No	No	0	5	2
207	R:R:I279	R:R:L283	2.85	No	No	0	5	1
208	R:R:A285	R:R:L280	3.15	No	No	0	1	4
209	R:R:L280	R:R:L286	2.77	No	No	0	4	1
210	R:R:L286	R:R:M281	5.65	No	No	7	1	3
211	R:R:M281	R:R:R288	2.48	No	No	0	3	4
212	R:R:M281	R:R:R292	3.72	No	Yes	7	3	3
213	R:R:D282	R:R:R288	9.53	No	No	0	2	4
214	R:R:L286	R:R:R292	10.93	No	Yes	7	1	3
215	R:R:N289	R:R:R292	9.64	No	Yes	0	5	3
216	R:R:R292	R:R:R295	4.26	Yes	No	0	3	3
217	L:L:?1	R:R:S304	5.94	Yes	No	1	0	5
218	L:L:?1	R:R:G307	5.8	Yes	No	0	0	8
219	L:L:?1	R:R:Y308	3.31	Yes	No	1	0	6
220	R:R:H310	R:R:N314	2.55	No	Yes	0	9	9
221	R:R:C312	R:R:L313	3.17	Yes	No	0	8	6
222	R:R:N314	R:R:Y318	4.65	Yes	Yes	1	9	9
223	R:R:L316	R:R:L317	2.77	No	Yes	0	6	8
224	R:R:A319	R:R:F325	8.32	No	Yes	3	7	8
225	R:R:F320	R:R:F325	8.57	No	Yes	3	7	8
226	R:R:F320	R:R:M329	4.98	No	No	0	7	6
227	R:R:R326	R:R:V323	7.85	No	No	0	8	5
228	R:R:K324	R:R:R328	11.14	No	No	4	6	5
229	R:R:L333	R:R:W330	2.28	No	No	0	6	2
230	R:R:G211	R:R:P208	2.03	No	No	0	4	4
231	R:R:C312	R:R:G67	1.96	Yes	No	0	8	8
232	R:R:C290	R:R:G291	1.96	No	No	0	8	2
233	R:R:A127	R:R:G128	1.95	No	No	0	5	6
234	R:R:A137	R:R:G138	1.95	No	No	0	7	9
235	R:R:A139	R:R:G223	1.95	No	No	0	8	5
236	R:R:P164	R:R:P165	1.95	No	No	0	6	2
237	R:R:A214	R:R:G211	1.95	No	No	0	3	4
238	L:L:?1	R:R:G128	1.93	Yes	No	0	0	6
239	R:R:A143	R:R:P227	1.87	No	No	0	7	9
240	R:R:G291	R:R:S294	1.86	No	No	0	2	3
241	R:R:G322	R:R:V321	1.84	No	No	0	8	7
242	R:R:A137	R:R:C179	1.81	No	No	0	7	8
243	R:R:P315	R:R:V74	1.77	No	Yes	0	9	9
244	R:R:C234	R:R:S146	1.72	No	No	1	7	9
245	R:R:G67	R:R:L66	1.71	No	No	0	8	6
246	R:R:G70	R:R:L69	1.71	No	No	0	7	5
247	R:R:C144	R:R:V175	1.71	No	No	0	7	7
248	R:R:C179	R:R:V175	1.71	No	No	0	8	7
249	R:R:G177	R:R:L180	1.71	No	No	0	4	4
250	R:R:A192	R:R:S191	1.71	No	No	0	5	4
251	R:R:G307	R:R:L306	1.71	No	No	0	8	8
252	R:R:G67	R:R:N71	1.7	No	Yes	0	8	9
253	R:R:G72	R:R:N71	1.7	No	Yes	0	4	9
254	R:R:A114	R:R:V115	1.7	No	No	0	5	4
255	R:R:G291	R:R:N289	1.7	No	No	0	2	5
256	R:R:A265	R:R:T269	1.68	No	No	0	5	5
257	R:R:L184	R:R:P185	1.64	No	No	0	4	7
258	R:R:S121	R:R:S191	1.63	No	No	0	3	4
259	R:R:A129	R:R:I133	1.62	No	Yes	0	5	6
260	R:R:C312	R:R:M309	1.62	Yes	No	0	8	5
261	R:R:D186	R:R:P185	1.61	No	No	0	4	7
262	R:R:V217	R:R:V221	1.6	No	No	0	4	5
263	R:R:V258	R:R:V262	1.6	No	No	0	5	5
264	R:R:V274	R:R:V296	1.6	Yes	No	0	4	4
265	R:R:V277	R:R:V296	1.6	No	No	0	5	4
266	R:R:V298	R:R:V302	1.6	No	No	0	2	6
267	R:R:A75	R:R:L93	1.58	No	Yes	0	7	6
268	R:R:A127	R:R:L108	1.58	No	No	0	5	6
269	R:R:A263	R:R:L317	1.58	No	Yes	0	6	8
270	R:R:G247	R:R:R250	1.5	No	Yes	0	3	6
271	R:R:G322	R:R:R326	1.5	No	No	0	8	8
272	R:R:L93	R:R:V97	1.49	Yes	No	0	6	6
273	R:R:N206	R:R:S191	1.49	No	No	0	4	4
274	R:R:L317	R:R:V259	1.49	Yes	No	0	8	5
275	R:R:L306	R:R:V302	1.49	No	No	0	8	6
276	R:R:E327	R:R:V323	1.43	No	No	0	5	5
277	R:R:G305	R:R:W109	1.41	No	Yes	0	5	5
278	R:R:L333	R:R:M329	1.41	No	No	0	6	6
279	R:R:A222	R:R:F182	1.39	No	Yes	0	5	5
280	R:R:L101	R:R:L104	1.38	No	No	0	5	5
281	R:R:A166	R:R:R161	1.38	No	No	0	4	4
282	R:R:L181	R:R:L184	1.38	No	No	0	5	4
283	R:R:A287	R:R:R292	1.38	No	Yes	0	1	3
284	R:R:H194	R:R:T201	1.37	No	No	0	2	5
285	R:R:R82	R:R:T83	1.29	No	No	0	5	6
286	R:R:M331	R:R:R335	1.24	No	No	0	4	4
287	R:R:L317	R:R:Y318	1.17	Yes	Yes	0	8	9
288	R:R:R252	R:R:R326	1.07	No	No	0	7	8
289	R:R:R162	R:R:Y160	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y60	5.135	4	0	8
2	R:R:N71	5.208	5	0	9
3	R:R:V74	3.808	5	3	9
4	R:R:D89	5.7825	4	4	8
5	R:R:F91	4.782	5	1	7
6	R:R:L93	3.535	4	0	6
7	R:R:H94	6.1275	4	0	9
8	R:R:L95	6.515	4	1	9
9	R:R:D99	6.96	4	1	9
10	R:R:L106	5.66	4	1	8
11	R:R:W109	4.008	5	1	5
12	R:R:W117	7.855	6	2	9
13	R:R:F119	7.9325	4	2	7
14	R:R:F131	8.69	5	1	5
15	R:R:I133	2.875	4	0	6
16	R:R:N134	6.4	4	5	8
17	R:R:F135	5.19	4	1	7
18	R:R:L142	4.44	5	1	8
19	R:R:R149	5.0425	4	1	9
20	R:R:Y150	5.745	6	1	8
21	R:R:W176	3.96	5	0	9
22	R:R:F182	5.455	4	0	5
23	R:R:F189	11.245	4	0	5
24	R:R:Y205	4.02	4	0	3
25	R:R:F224	8.925	4	1	8
26	R:R:M231	5.99	4	1	8
27	R:R:Y235	5.6925	8	1	8
28	R:R:R250	5.45	4	0	6
29	R:R:F264	9.585	4	1	9
30	R:R:W268	7.56	7	1	9
31	R:R:Y271	7.616	5	1	6
32	R:R:H272	8.12	5	1	8
33	R:R:V274	3.1775	4	0	4
34	R:R:R292	5.986	5	7	3
35	R:R:C312	2.48	4	0	8
36	R:R:N314	4.984	5	1	9
37	R:R:L317	1.7525	4	0	8
38	R:R:Y318	4.81	7	1	9
39	R:R:F325	8.1575	4	3	8
40	L:L:?1	7.64	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D99	R:R:N71	57.5784	5.39	Yes	Yes	0	9	9
2	R:R:G67	R:R:N71	11.4043	1.7	No	Yes	0	8	9
3	L:L:?1	R:R:W109	13.3861	2.57	Yes	Yes	1	0	5
4	L:L:?1	R:R:W268	31.4043	4.5	Yes	Yes	1	0	9
5	R:R:H310	R:R:W268	47.2237	9.52	No	Yes	0	9	9
6	R:R:H310	R:R:N314	47.1533	2.55	No	Yes	0	9	9
7	R:R:D99	R:R:N314	48.0973	6.73	Yes	Yes	1	9	9
8	R:R:N71	R:R:P315	45.0894	11.4	Yes	No	0	9	9
9	R:R:P315	R:R:V74	41.114	1.77	No	Yes	0	9	9
10	R:R:A319	R:R:V74	27.0067	3.39	No	Yes	3	7	9
11	R:R:A319	R:R:L92	26.5963	4.73	No	No	0	7	8
12	R:R:L78	R:R:L92	25.0718	4.15	No	No	0	7	8
13	R:R:L78	R:R:L85	17.4084	4.15	No	No	0	7	6
14	R:R:R149	R:R:T88	11.5215	2.59	Yes	No	0	9	8
15	R:R:M231	R:R:Y235	19.8769	2.39	Yes	Yes	1	8	8
16	R:R:F264	R:R:M231	29.698	11.2	Yes	Yes	1	9	8
17	R:R:F264	R:R:W268	45.1774	21.05	Yes	Yes	1	9	9
18	R:R:L142	R:R:Y318	15.7901	5.86	Yes	Yes	1	8	9
19	R:R:F264	R:R:L142	18.0065	2.44	Yes	Yes	1	9	8
20	R:R:N314	R:R:Y318	28.5547	4.65	Yes	Yes	1	9	9
21	R:R:H94	R:R:W176	19.7948	7.41	Yes	Yes	0	9	9
22	R:R:N134	R:R:W176	21.0437	2.26	Yes	Yes	0	8	9
23	R:R:L102	R:R:N134	21.114	6.87	No	Yes	0	6	8
24	R:R:F131	R:R:L102	22.6737	9.74	Yes	No	0	5	6
25	R:R:I145	R:R:Y318	17.9947	6.04	No	Yes	1	9	9
26	R:R:F91	R:R:I145	21.7004	3.77	Yes	No	1	7	9
27	R:R:L141	R:R:L95	19.7303	4.15	No	Yes	0	8	9
28	R:R:L142	R:R:L95	13.6265	5.54	Yes	Yes	1	8	9
29	R:R:F119	R:R:W117	14.723	14.03	Yes	Yes	2	7	9
30	R:R:C203	R:R:W117	30.3782	2.61	No	Yes	2	9	9
31	R:R:C203	R:R:L190	33.8434	3.17	No	No	0	9	5
32	R:R:L190	R:R:Y205	35.5086	7.03	No	Yes	0	5	3
33	R:R:R212	R:R:Y205	64.7787	2.06	No	Yes	0	4	3
34	R:R:R212	R:R:R216	70.3254	2.13	No	No	0	4	3
35	R:R:D278	R:R:R216	79.7596	4.76	No	No	0	5	3
36	R:R:D278	R:R:D282	81.0789	11.98	No	No	0	5	2
37	R:R:D282	R:R:R288	82.3688	9.53	No	No	0	2	4
38	R:R:M281	R:R:R288	84.7728	2.48	No	No	0	3	4
39	R:R:L286	R:R:M281	83.7702	5.65	No	No	7	1	3
40	R:R:L280	R:R:L286	95.4735	2.77	No	No	0	4	1
41	R:R:L276	R:R:L280	97.7602	2.77	No	No	0	5	4
42	R:R:L220	R:R:L276	98.886	2.77	No	No	0	4	5
43	R:R:H272	R:R:L220	100	3.86	Yes	No	0	8	4
44	R:R:F135	R:R:H272	22.0522	2.26	Yes	Yes	1	7	8
45	R:R:H272	R:R:W268	69.6042	4.23	Yes	Yes	1	8	9
46	R:R:H272	R:R:Y271	20.0352	7.62	Yes	Yes	1	8	6
47	L:L:?1	R:R:Y271	16.1478	17.88	Yes	Yes	1	0	6
48	R:R:D112	R:R:W117	11.1287	8.93	No	Yes	0	5	9
49	R:R:F119	R:R:V118	11.1463	5.24	Yes	No	0	7	3
50	R:R:F189	R:R:N206	11.1463	3.62	Yes	No	0	5	4
51	R:R:F189	R:R:P185	21.8763	2.89	Yes	No	0	5	7
52	R:R:D186	R:R:P185	27.083	1.61	No	No	0	4	7
53	R:R:D186	R:R:Y205	30.472	2.3	No	Yes	0	4	3
54	R:R:I133	R:R:W176	11.6036	2.35	Yes	Yes	0	6	9
55	R:R:A137	R:R:C179	10.085	1.81	No	No	0	7	8
56	R:R:A137	R:R:W176	13.1926	5.19	No	Yes	0	7	9
57	R:R:A139	R:R:W268	10.3723	2.59	No	Yes	0	8	9
58	R:R:M231	R:R:S146	20.2111	6.13	Yes	No	1	8	9
59	R:R:C234	R:R:S146	26.9364	1.72	No	No	1	7	9
60	R:R:C234	R:R:Y150	18.8391	5.38	No	Yes	1	7	8
61	R:R:I238	R:R:Y235	19.5368	2.42	No	Yes	0	8	8
62	R:R:I279	R:R:R216	11.1463	3.76	No	No	0	5	3
63	R:R:I238	R:R:L242	15.8487	2.85	No	No	0	8	8
64	R:R:L242	R:R:M254	11.9554	4.24	No	No	0	8	6
65	R:R:T303	R:R:Y271	14.1894	4.99	No	Yes	0	7	6
66	R:R:T303	R:R:V274	11.2811	3.17	No	Yes	0	7	4
67	R:R:L286	R:R:R292	10.5365	10.93	No	Yes	7	1	3
68	R:R:D99	R:R:L95	11.9496	9.5	Yes	Yes	1	9	9
69	R:R:H94	R:R:L141	17.7602	2.57	Yes	No	0	9	8
70	R:R:F131	R:R:F135	18.4814	4.29	Yes	Yes	1	5	7
71	R:R:L142	R:R:M231	11.5919	4.24	Yes	Yes	1	8	8
72	R:R:Y235	R:R:Y318	17.6546	4.96	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L106	R:R:Y60	2.34	1	Yes	Yes	8	8	2	2
R:R:W109	R:R:Y60	4.82	1	Yes	Yes	5	8	1	2
R:R:F131	R:R:L102	9.74	1	Yes	No	5	6	1	2
R:R:F131	R:R:T105	2.59	1	Yes	No	5	7	1	2
R:R:L106	R:R:Y308	11.72	1	Yes	No	8	6	2	1
R:R:A113	R:R:W109	2.59	0	No	Yes	5	5	2	1
R:R:S304	R:R:W109	8.65	1	No	Yes	5	5	1	1
L:L:?1	R:R:W109	2.57	1	Yes	Yes	0	5	0	1
R:R:F131	R:R:F135	4.29	1	Yes	Yes	5	7	1	1
R:R:F131	R:R:Y308	6.19	1	Yes	No	5	6	1	1
L:L:?1	R:R:F131	20.64	1	Yes	Yes	0	5	0	1
R:R:F135	R:R:W268	8.02	1	Yes	Yes	7	9	1	1
R:R:F135	R:R:H272	2.26	1	Yes	Yes	7	8	1	2
L:L:?1	R:R:F135	6.19	1	Yes	Yes	0	7	0	1
R:R:A139	R:R:W268	2.59	0	No	Yes	8	9	2	1
R:R:F224	R:R:W268	3.01	1	Yes	Yes	8	9	2	1
R:R:F224	R:R:H272	22.63	1	Yes	Yes	8	8	2	2
R:R:F264	R:R:W268	21.05	1	Yes	Yes	9	9	2	1
R:R:H272	R:R:W268	4.23	1	Yes	Yes	8	9	2	1
R:R:H310	R:R:W268	9.52	0	No	Yes	9	9	2	1
L:L:?1	R:R:W268	4.5	1	Yes	Yes	0	9	0	1
R:R:H272	R:R:Y271	7.62	1	Yes	Yes	8	6	2	1
R:R:V275	R:R:Y271	5.05	0	No	Yes	5	6	2	1
R:R:T303	R:R:Y271	4.99	0	No	Yes	7	6	2	1
R:R:S304	R:R:Y271	2.54	1	No	Yes	5	6	1	1
L:L:?1	R:R:Y271	17.88	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S304	5.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:G307	5.8	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y308	3.31	1	Yes	No	0	6	0	1
R:R:A127	R:R:G128	1.95	0	No	No	5	6	2	1
L:L:?1	R:R:G128	1.93	1	Yes	No	0	6	0	1
R:R:G307	R:R:L306	1.71	0	No	No	8	8	1	2
R:R:G305	R:R:W109	1.41	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y0N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.06
Number of Linked Nodes	254
Number of Links	289
Number of Hubs	40
Number of Links mediated by Hubs	154
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	40667
Length Of Smallest Path	3
Average Path Length	13.878
Length of Longest Path	36
Minimum Path Strength	1.285
Average Path Strength	5.35309
Maximum Path Strength	19.26
Minimum Path Correlation	0.7
Average Path Correlation	0.922188
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	48.3584
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.5789
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell adhesion • regulation of cell adhesion • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • calcium-mediated signaling • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8Y0N_nogp_Chain_R P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	10.1038/s41594-023-01175-5
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	To be published
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	To be published
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	To be published
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go1/β1/γ2	3.07	2025-02-26	To be published
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	To be published
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go1/β1/γ2	3.03	2025-02-26	To be published
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	To be published
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go1/β1/γ2	3.3	2025-02-26	To be published
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Y0N_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.