psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L59	R:R:Y60	9.38	No	Yes	0	6	8
2	R:R:L106	R:R:Y60	2.34	Yes	Yes	0	8	8
3	R:R:W109	R:R:Y60	4.82	Yes	Yes	0	5	8
4	R:R:A110	R:R:Y60	4	No	Yes	0	7	8
5	R:R:L65	R:R:S61	3	No	No	0	5	6
6	R:R:L62	R:R:L66	4.15	No	No	0	5	6
7	R:R:C312	R:R:L63	3.17	Yes	No	0	8	7
8	R:R:F64	R:R:L68	10.96	No	No	0	7	6
9	R:R:F64	R:R:L106	3.65	No	Yes	1	7	8
10	R:R:F64	R:R:P107	4.33	No	No	1	7	9
11	R:R:L68	R:R:V103	2.98	No	No	0	6	6
12	R:R:G70	R:R:P315	4.06	No	No	0	7	9
13	R:R:D99	R:R:N71	5.39	Yes	Yes	0	9	9
14	R:R:N71	R:R:T100	5.85	Yes	No	0	9	7
15	R:R:N71	R:R:P315	11.4	Yes	No	0	9	9
16	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
17	R:R:A319	R:R:V74	3.39	No	Yes	3	7	9
18	R:R:F320	R:R:V74	2.62	No	Yes	3	7	9
19	R:R:F325	R:R:V74	7.87	Yes	Yes	3	8	9
20	R:R:F325	R:R:V77	7.87	Yes	No	0	8	7
21	R:R:M329	R:R:V77	3.04	No	No	0	6	7
22	R:R:L332	R:R:V77	2.98	No	No	0	5	7
23	R:R:L78	R:R:L85	4.15	No	No	0	7	6
24	R:R:L78	R:R:L92	4.15	No	No	0	7	8
25	R:R:L78	R:R:L93	6.92	No	Yes	0	7	6
26	R:R:L79	R:R:L93	4.15	No	Yes	0	4	6
27	R:R:L332	R:R:S80	9.01	No	No	0	5	5
28	R:R:R81	R:R:T83	12.94	No	No	0	5	6
29	R:R:L85	R:R:R81	2.43	No	No	0	6	5
30	R:R:R328	R:R:R81	17.06	No	No	0	5	5
31	R:R:R335	R:R:R82	9.6	No	No	0	4	5
32	R:R:A84	R:R:P165	3.74	No	No	0	7	2
33	R:R:D89	R:R:L85	8.14	Yes	No	0	8	6
34	R:R:D89	R:R:S86	5.89	Yes	No	0	8	7
35	R:R:D148	R:R:S87	5.89	No	No	0	8	6
36	R:R:D148	R:R:T88	7.23	No	No	0	8	8
37	R:R:R149	R:R:T88	2.59	Yes	No	0	9	8
38	R:R:D89	R:R:K324	5.53	Yes	No	4	8	6
39	R:R:D89	R:R:R328	3.57	Yes	No	4	8	5
40	R:R:H94	R:R:T90	2.74	Yes	No	0	9	6
41	R:R:T90	R:R:V168	4.76	No	No	0	6	8
42	R:R:C144	R:R:F91	5.59	No	Yes	0	7	7
43	R:R:F91	R:R:I145	3.77	Yes	No	1	7	9
44	R:R:F91	R:R:V168	7.87	Yes	No	1	7	8
45	R:R:F91	R:R:T171	3.89	Yes	No	1	7	5
46	R:R:C172	R:R:F91	2.79	No	Yes	0	7	7
47	R:R:A319	R:R:L92	4.73	No	No	0	7	8
48	R:R:H94	R:R:L141	2.57	Yes	No	0	9	8
49	R:R:C172	R:R:H94	11.79	No	Yes	0	7	9
50	R:R:H94	R:R:W176	7.41	Yes	Yes	0	9	9
51	R:R:D99	R:R:L95	9.5	Yes	Yes	1	9	9
52	R:R:L141	R:R:L95	4.15	No	Yes	0	8	9
53	R:R:L142	R:R:L95	5.54	Yes	Yes	1	8	9
54	R:R:L95	R:R:N314	6.87	Yes	Yes	1	9	9
55	R:R:A98	R:R:W176	2.59	No	Yes	0	8	9
56	R:R:C311	R:R:D99	6.22	No	Yes	0	8	9
57	R:R:D99	R:R:N314	6.73	Yes	Yes	1	9	9
58	R:R:L101	R:R:L130	2.77	No	No	1	5	5
59	R:R:L101	R:R:N134	10.98	No	Yes	1	5	8
60	R:R:F131	R:R:L102	9.74	Yes	No	1	5	6
61	R:R:L102	R:R:N134	6.87	No	Yes	1	6	8
62	L:L:?1	R:R:L102	2.18	Yes	No	1	0	6
63	R:R:C311	R:R:V103	3.42	No	No	0	8	6
64	R:R:F131	R:R:T105	2.59	Yes	No	0	5	7
65	R:R:L106	R:R:P107	4.93	Yes	No	1	8	9
66	R:R:L106	R:R:Y308	11.72	Yes	No	1	8	6
67	R:R:A113	R:R:W109	2.59	No	Yes	0	5	5
68	R:R:S304	R:R:W109	8.65	No	Yes	1	5	5
69	L:L:?1	R:R:W109	3.59	Yes	Yes	1	0	5
70	R:R:F119	R:R:V111	3.93	Yes	No	0	7	4
71	R:R:D112	R:R:W117	8.93	No	Yes	0	5	9
72	R:R:D112	R:R:H202	3.78	No	No	0	5	3
73	R:R:Q116	R:R:V115	5.73	No	No	0	3	4
74	R:R:Q116	R:R:V118	4.3	No	No	0	3	3
75	R:R:Q116	R:R:T201	4.25	No	No	0	3	5
76	R:R:F119	R:R:W117	14.03	Yes	Yes	2	7	9
77	R:R:G120	R:R:W117	2.81	No	Yes	0	8	9
78	R:R:L123	R:R:W117	5.69	No	Yes	2	6	9
79	R:R:C124	R:R:W117	13.06	No	Yes	2	9	9
80	R:R:C203	R:R:W117	2.61	No	Yes	2	9	9
81	R:R:F119	R:R:V118	5.24	Yes	No	0	7	3
82	R:R:F119	R:R:L123	8.53	Yes	No	2	7	6
83	R:R:G122	R:R:S121	3.71	No	No	0	1	3
84	R:R:K125	R:R:S121	4.59	No	No	0	7	3
85	R:R:C124	R:R:C203	7.28	No	No	2	9	9
86	L:L:?1	R:R:G128	2.69	Yes	No	0	0	6
87	R:R:A129	R:R:F187	8.32	No	No	0	5	4
88	R:R:L130	R:R:N134	5.49	No	Yes	1	5	8
89	R:R:F131	R:R:F135	4.29	Yes	Yes	1	5	7
90	R:R:F131	R:R:Y308	6.19	Yes	No	1	5	6
91	L:L:?1	R:R:F131	28.77	Yes	Yes	1	0	5
92	R:R:D186	R:R:N132	12.12	No	No	0	4	4
93	R:R:I133	R:R:W176	2.35	Yes	Yes	0	6	9
94	R:R:I133	R:R:L180	4.28	Yes	No	0	6	4
95	R:R:A183	R:R:I133	3.25	No	Yes	0	7	6
96	R:R:N134	R:R:W176	2.26	Yes	Yes	0	8	9
97	R:R:F135	R:R:W268	8.02	Yes	Yes	1	7	9
98	R:R:F135	R:R:H272	2.26	Yes	Yes	1	7	8
99	L:L:?1	R:R:F135	8.63	Yes	Yes	1	0	7
100	R:R:C179	R:R:Y136	2.69	No	No	0	8	6
101	R:R:F182	R:R:Y136	8.25	Yes	No	0	5	6
102	R:R:Q219	R:R:Y136	4.51	No	No	0	5	6
103	R:R:A137	R:R:W176	5.19	No	Yes	0	7	9
104	R:R:A139	R:R:W268	2.59	No	Yes	0	8	9
105	R:R:L140	R:R:V175	4.47	No	No	0	6	7
106	R:R:L142	R:R:M231	4.24	Yes	Yes	1	8	8
107	R:R:F264	R:R:L142	2.44	Yes	Yes	1	9	8
108	R:R:L142	R:R:N314	4.12	Yes	Yes	1	8	9
109	R:R:L142	R:R:Y318	5.86	Yes	Yes	1	8	9
110	R:R:A143	R:R:V230	3.39	No	No	0	7	7
111	R:R:I145	R:R:R149	6.26	No	Yes	1	9	9
112	R:R:I145	R:R:Y318	6.04	No	Yes	1	9	9
113	R:R:M231	R:R:S146	6.13	Yes	No	1	8	9
114	R:R:S146	R:R:Y235	12.72	No	Yes	1	9	8
115	R:R:F147	R:R:Y150	2.06	No	Yes	1	6	8
116	R:R:F147	R:R:L151	8.53	No	No	1	6	5
117	R:R:C234	R:R:F147	2.79	No	No	1	7	6
118	R:R:D148	R:R:N152	5.39	No	No	0	8	8
119	R:R:R149	R:R:Y235	4.12	Yes	Yes	1	9	8
120	R:R:R149	R:R:Y318	7.2	Yes	Yes	1	9	9
121	R:R:L151	R:R:Y150	3.52	No	Yes	1	5	8
122	R:R:V154	R:R:Y150	12.62	No	Yes	1	7	8
123	R:R:H155	R:R:Y150	6.53	No	Yes	1	6	8
124	R:R:C234	R:R:Y150	5.38	No	Yes	1	7	8
125	R:R:H237	R:R:Y150	4.36	No	Yes	0	4	8
126	R:R:L151	R:R:L159	5.54	No	No	0	5	6
127	R:R:I153	R:R:I238	5.89	No	No	0	8	8
128	R:R:H155	R:R:V154	5.54	No	No	1	6	7
129	R:R:V154	R:R:V241	6.41	No	No	0	7	5
130	R:R:H155	R:R:Q158	7.42	No	No	0	6	4
131	R:R:P164	R:R:R161	10.09	No	No	0	6	4
132	R:R:G163	R:R:P164	4.06	No	No	0	6	6
133	R:R:R167	R:R:T169	5.17	No	No	0	4	4
134	R:R:T171	R:R:V168	4.76	No	No	1	5	8
135	R:R:L173	R:R:T169	4.42	No	No	0	5	4
136	R:R:F182	R:R:L178	7.31	Yes	No	0	5	4
137	R:R:F182	R:R:L218	4.87	Yes	No	0	5	3
138	R:R:F189	R:R:P185	2.89	Yes	No	0	5	7
139	R:R:D186	R:R:Y205	2.3	No	Yes	0	4	3
140	R:R:F189	R:R:I188	13.82	Yes	No	0	5	4
141	R:R:F189	R:R:N206	3.62	Yes	No	0	5	4
142	R:R:F189	R:R:F207	24.65	Yes	No	0	5	4
143	R:R:C203	R:R:L190	3.17	No	No	0	9	5
144	R:R:L190	R:R:Y205	7.03	No	Yes	0	5	3
145	R:R:D195	R:R:H193	11.35	No	No	5	2	3
146	R:R:H193	R:R:Q204	12.36	No	No	5	3	3
147	R:R:D195	R:R:Q204	5.22	No	No	5	2	3
148	R:R:L198	R:R:R197	13.36	No	No	0	1	4
149	R:R:E293	R:R:R197	22.1	No	No	0	1	4
150	R:R:H202	R:R:L198	2.57	No	No	0	3	1
151	R:R:A200	R:R:H202	4.39	No	No	0	1	3
152	R:R:Q204	R:R:R212	8.18	No	No	0	3	4
153	R:R:R212	R:R:Y205	2.06	No	Yes	0	4	3
154	R:R:L215	R:R:Y205	4.69	No	Yes	0	5	3
155	R:R:F207	R:R:P208	4.33	No	No	0	4	4
156	R:R:Q209	R:R:R288	4.67	No	No	0	2	4
157	R:R:R212	R:R:R216	2.13	No	No	0	4	3
158	R:R:L283	R:R:T213	2.95	No	No	0	1	1
159	R:R:D278	R:R:R216	4.76	No	No	0	5	3
160	R:R:I279	R:R:R216	3.76	No	No	0	5	3
161	R:R:I279	R:R:V217	3.07	No	No	0	5	4
162	R:R:H272	R:R:L220	3.86	Yes	No	0	8	4
163	R:R:L220	R:R:L276	2.77	No	No	0	4	5
164	R:R:L225	R:R:V221	4.47	No	No	0	4	5
165	R:R:G223	R:R:P227	4.06	No	No	0	5	9
166	R:R:F224	R:R:L228	4.87	Yes	No	0	8	7
167	R:R:F224	R:R:W268	3.01	Yes	Yes	1	8	9
168	R:R:F224	R:R:T269	5.19	Yes	No	0	8	5
169	R:R:F224	R:R:H272	22.63	Yes	Yes	1	8	8
170	R:R:L226	R:R:P227	6.57	No	No	0	6	9
171	R:R:F264	R:R:L228	3.65	Yes	No	0	9	7
172	R:R:M231	R:R:Y235	2.39	Yes	Yes	1	8	8
173	R:R:F264	R:R:M231	11.2	Yes	Yes	1	9	8
174	R:R:H237	R:R:Y233	10.89	No	No	0	4	4
175	R:R:I238	R:R:Y235	2.42	No	Yes	0	8	8
176	R:R:V257	R:R:Y235	10.09	No	Yes	0	7	8
177	R:R:V260	R:R:Y235	3.79	No	Yes	1	8	8
178	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
179	R:R:Y235	R:R:Y318	4.96	Yes	Yes	1	8	9
180	R:R:I238	R:R:L242	2.85	No	No	0	8	8
181	R:R:L239	R:R:V257	4.47	No	No	0	5	7
182	R:R:L239	R:R:V258	4.47	No	No	0	5	5
183	R:R:A253	R:R:L242	3.15	No	No	0	7	8
184	R:R:L242	R:R:M254	4.24	No	No	0	8	6
185	R:R:L243	R:R:M254	7.07	No	No	0	4	6
186	R:R:R250	R:R:S245	9.22	Yes	No	0	6	4
187	R:R:L251	R:R:R250	3.64	No	Yes	0	5	6
188	R:R:M254	R:R:R250	7.44	No	Yes	0	6	6
189	R:R:L256	R:R:V321	8.94	No	No	0	8	7
190	R:R:V260	R:R:Y318	3.79	No	Yes	1	8	9
191	R:R:L266	R:R:V262	2.98	No	No	0	5	5
192	R:R:F264	R:R:W268	21.05	Yes	Yes	1	9	9
193	R:R:C267	R:R:H310	7.37	No	No	0	9	9
194	R:R:H272	R:R:W268	4.23	Yes	Yes	1	8	9
195	R:R:H310	R:R:W268	9.52	No	Yes	0	9	9
196	L:L:?1	R:R:W268	6.28	Yes	Yes	1	0	9
197	R:R:P270	R:R:T269	3.5	No	No	0	9	5
198	R:R:P270	R:R:T303	3.5	No	No	0	9	7
199	R:R:H272	R:R:Y271	7.62	Yes	Yes	1	8	6
200	R:R:V275	R:R:Y271	5.05	No	Yes	0	5	6
201	R:R:T303	R:R:Y271	4.99	No	Yes	0	7	6
202	R:R:S304	R:R:Y271	2.54	No	Yes	1	5	6
203	L:L:?1	R:R:Y271	24.93	Yes	Yes	1	0	6
204	R:R:A299	R:R:V274	3.39	No	Yes	0	5	4
205	R:R:K300	R:R:V274	4.55	No	Yes	0	5	4
206	R:R:T303	R:R:V274	3.17	No	Yes	0	7	4
207	R:R:L276	R:R:L280	2.77	No	No	0	5	4
208	R:R:D278	R:R:D282	11.98	No	No	0	5	2
209	R:R:I279	R:R:L283	2.85	No	No	0	5	1
210	R:R:A285	R:R:L280	3.15	No	No	0	1	4
211	R:R:L280	R:R:L286	2.77	No	No	0	4	1
212	R:R:L286	R:R:M281	5.65	No	No	6	1	3
213	R:R:M281	R:R:R288	2.48	No	No	0	3	4
214	R:R:M281	R:R:R292	3.72	No	Yes	6	3	3
215	R:R:D282	R:R:R288	9.53	No	No	0	2	4
216	R:R:L286	R:R:R292	10.93	No	Yes	6	1	3
217	R:R:N289	R:R:R292	9.64	No	Yes	0	5	3
218	R:R:R292	R:R:R295	4.26	Yes	No	0	3	3
219	L:L:?1	R:R:S304	8.28	Yes	No	1	0	5
220	L:L:?1	R:R:G307	8.08	Yes	No	0	0	8
221	L:L:?1	R:R:Y308	4.62	Yes	No	1	0	6
222	R:R:H310	R:R:N314	2.55	No	Yes	0	9	9
223	R:R:C312	R:R:L313	3.17	Yes	No	0	8	6
224	R:R:N314	R:R:Y318	4.65	Yes	Yes	1	9	9
225	R:R:L316	R:R:L317	2.77	No	Yes	0	6	8
226	R:R:A319	R:R:F325	8.32	No	Yes	3	7	8
227	R:R:F320	R:R:F325	8.57	No	Yes	3	7	8
228	R:R:F320	R:R:M329	4.98	No	No	0	7	6
229	R:R:R326	R:R:V323	7.85	No	No	0	8	5
230	R:R:K324	R:R:R328	11.14	No	No	4	6	5
231	R:R:L333	R:R:W330	2.28	No	No	0	6	2
232	R:R:G211	R:R:P208	2.03	No	No	0	4	4
233	R:R:C312	R:R:G67	1.96	Yes	No	0	8	8
234	R:R:C290	R:R:G291	1.96	No	No	0	8	2
235	R:R:A127	R:R:G128	1.95	No	No	0	5	6
236	R:R:A137	R:R:G138	1.95	No	No	0	7	9
237	R:R:A139	R:R:G223	1.95	No	No	0	8	5
238	R:R:P164	R:R:P165	1.95	No	No	0	6	2
239	R:R:A214	R:R:G211	1.95	No	No	0	3	4
240	R:R:A143	R:R:P227	1.87	No	No	0	7	9
241	R:R:G291	R:R:S294	1.86	No	No	0	2	3
242	R:R:G322	R:R:V321	1.84	No	No	0	8	7
243	R:R:A137	R:R:C179	1.81	No	No	0	7	8
244	R:R:P315	R:R:V74	1.77	No	Yes	0	9	9
245	R:R:C234	R:R:S146	1.72	No	No	1	7	9
246	R:R:G67	R:R:L66	1.71	No	No	0	8	6
247	R:R:G70	R:R:L69	1.71	No	No	0	7	5
248	R:R:C144	R:R:V175	1.71	No	No	0	7	7
249	R:R:C179	R:R:V175	1.71	No	No	0	8	7
250	R:R:G177	R:R:L180	1.71	No	No	0	4	4
251	R:R:A192	R:R:S191	1.71	No	No	0	5	4
252	R:R:G307	R:R:L306	1.71	No	No	0	8	8
253	R:R:G67	R:R:N71	1.7	No	Yes	0	8	9
254	R:R:G72	R:R:N71	1.7	No	Yes	0	4	9
255	R:R:A114	R:R:V115	1.7	No	No	0	5	4
256	R:R:G291	R:R:N289	1.7	No	No	0	2	5
257	R:R:A265	R:R:T269	1.68	No	No	0	5	5
258	R:R:L184	R:R:P185	1.64	No	No	0	4	7
259	R:R:S121	R:R:S191	1.63	No	No	0	3	4
260	R:R:A129	R:R:I133	1.62	No	Yes	0	5	6
261	R:R:C312	R:R:M309	1.62	Yes	No	0	8	5
262	R:R:D186	R:R:P185	1.61	No	No	0	4	7
263	R:R:V217	R:R:V221	1.6	No	No	0	4	5
264	R:R:V258	R:R:V262	1.6	No	No	0	5	5
265	R:R:V274	R:R:V296	1.6	Yes	No	0	4	4
266	R:R:V277	R:R:V296	1.6	No	No	0	5	4
267	R:R:V298	R:R:V302	1.6	No	No	0	2	6
268	R:R:A75	R:R:L93	1.58	No	Yes	0	7	6
269	R:R:A127	R:R:L108	1.58	No	No	0	5	6
270	R:R:A263	R:R:L317	1.58	No	Yes	0	6	8
271	R:R:G247	R:R:R250	1.5	No	Yes	0	3	6
272	R:R:G322	R:R:R326	1.5	No	No	0	8	8
273	R:R:L93	R:R:V97	1.49	Yes	No	0	6	6
274	R:R:N206	R:R:S191	1.49	No	No	0	4	4
275	R:R:L317	R:R:V259	1.49	Yes	No	0	8	5
276	R:R:L306	R:R:V302	1.49	No	No	0	8	6
277	R:R:E327	R:R:V323	1.43	No	No	0	5	5
278	R:R:G305	R:R:W109	1.41	No	Yes	0	5	5
279	R:R:L333	R:R:M329	1.41	No	No	0	6	6
280	R:R:A222	R:R:F182	1.39	No	Yes	0	5	5
281	R:R:L101	R:R:L104	1.38	No	No	0	5	5
282	R:R:A166	R:R:R161	1.38	No	No	0	4	4
283	R:R:L181	R:R:L184	1.38	No	No	0	5	4
284	R:R:A287	R:R:R292	1.38	No	Yes	0	1	3
285	R:R:H194	R:R:T201	1.37	No	No	0	2	5
286	R:R:R82	R:R:T83	1.29	No	No	0	5	6
287	R:R:M331	R:R:R335	1.24	No	No	0	4	4
288	R:R:L317	R:R:Y318	1.17	Yes	Yes	0	8	9
289	R:R:R252	R:R:R326	1.07	No	No	0	7	8
290	R:R:R162	R:R:Y160	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y60	5.135	4	0	8
2	R:R:N71	5.208	5	0	9
3	R:R:V74	3.808	5	3	9
4	R:R:D89	5.7825	4	4	8
5	R:R:F91	4.782	5	1	7
6	R:R:L93	3.535	4	0	6
7	R:R:H94	6.1275	4	0	9
8	R:R:L95	6.515	4	1	9
9	R:R:D99	6.96	4	1	9
10	R:R:L106	5.66	4	1	8
11	R:R:W109	4.212	5	1	5
12	R:R:W117	7.855	6	2	9
13	R:R:F119	7.9325	4	2	7
14	R:R:F131	10.316	5	1	5
15	R:R:I133	2.875	4	0	6
16	R:R:N134	6.4	4	1	8
17	R:R:F135	5.8	4	1	7
18	R:R:L142	4.44	5	1	8
19	R:R:R149	5.0425	4	1	9
20	R:R:Y150	5.745	6	1	8
21	R:R:W176	3.96	5	0	9
22	R:R:F182	5.455	4	0	5
23	R:R:F189	11.245	4	0	5
24	R:R:Y205	4.02	4	0	3
25	R:R:F224	8.925	4	1	8
26	R:R:M231	5.99	4	1	8
27	R:R:Y235	5.6925	8	1	8
28	R:R:R250	5.45	4	0	6
29	R:R:F264	9.585	4	1	9
30	R:R:W268	7.81429	7	1	9
31	R:R:Y271	9.026	5	1	6
32	R:R:H272	8.12	5	1	8
33	R:R:V274	3.1775	4	0	4
34	R:R:R292	5.986	5	6	3
35	R:R:C312	2.48	4	0	8
36	R:R:N314	4.984	5	1	9
37	R:R:L317	1.7525	4	0	8
38	R:R:Y318	4.81	7	1	9
39	R:R:F325	8.1575	4	3	8
40	L:L:?1	9.805	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D99	R:R:N71	43.3147	5.39	Yes	Yes	0	9	9
2	L:L:?1	R:R:W109	10.2615	3.59	Yes	Yes	1	0	5
3	L:L:?1	R:R:W268	32.6706	6.28	Yes	Yes	1	0	9
4	R:R:H310	R:R:W268	35.6552	9.52	No	Yes	0	9	9
5	R:R:H310	R:R:N314	35.4951	2.55	No	Yes	0	9	9
6	R:R:D99	R:R:N314	36.2957	6.73	Yes	Yes	1	9	9
7	R:R:N71	R:R:P315	33.9294	11.4	Yes	No	0	9	9
8	R:R:P315	R:R:V74	30.9403	1.77	No	Yes	0	9	9
9	R:R:A319	R:R:V74	20.3274	3.39	No	Yes	3	7	9
10	R:R:A319	R:R:L92	20.0249	4.73	No	No	0	7	8
11	R:R:L78	R:R:L92	18.8773	4.15	No	No	0	7	8
12	R:R:L78	R:R:L85	13.1083	4.15	No	No	0	7	6
13	R:R:M231	R:R:Y235	14.3893	2.39	Yes	Yes	1	8	8
14	R:R:F264	R:R:M231	21.8086	11.2	Yes	Yes	1	9	8
15	R:R:F264	R:R:W268	33.5735	21.05	Yes	Yes	1	9	9
16	R:R:L142	R:R:Y318	11.5737	5.86	Yes	Yes	1	8	9
17	R:R:F264	R:R:L142	13.5486	2.44	Yes	Yes	1	9	8
18	R:R:N314	R:R:Y318	21.2703	4.65	Yes	Yes	1	9	9
19	R:R:H94	R:R:W176	16.4932	7.41	Yes	Yes	0	9	9
20	R:R:N134	R:R:W176	34.5165	2.26	Yes	Yes	0	8	9
21	R:R:L102	R:R:N134	39.4093	6.87	No	Yes	1	6	8
22	L:L:?1	R:R:L102	31.9055	2.18	Yes	No	1	0	6
23	R:R:F91	R:R:I145	15.5191	3.77	Yes	No	1	7	9
24	R:R:I145	R:R:Y318	13.0415	6.04	No	Yes	1	9	9
25	R:R:A137	R:R:C179	15.8749	1.81	No	No	0	7	8
26	R:R:A137	R:R:W176	20.0027	5.19	No	Yes	0	7	9
27	R:R:H94	R:R:L141	12.1786	2.57	Yes	No	0	9	8
28	R:R:L141	R:R:L95	13.562	4.15	No	Yes	0	8	9
29	R:R:F119	R:R:W117	14.0512	14.03	Yes	Yes	2	7	9
30	R:R:C203	R:R:W117	29.17	2.61	No	Yes	2	9	9
31	R:R:C203	R:R:L190	32.5193	3.17	No	No	0	9	5
32	R:R:L190	R:R:Y205	34.1429	7.03	No	Yes	0	5	3
33	R:R:R212	R:R:Y205	63.1928	2.06	No	Yes	0	4	3
34	R:R:R212	R:R:R216	68.8417	2.13	No	No	0	4	3
35	R:R:D278	R:R:R216	78.5206	4.76	No	No	0	5	3
36	R:R:D278	R:R:D282	79.8817	11.98	No	No	0	5	2
37	R:R:D282	R:R:R288	81.2205	9.53	No	No	0	2	4
38	R:R:M281	R:R:R288	83.7648	2.48	No	No	0	3	4
39	R:R:L286	R:R:M281	83.3645	5.65	No	No	6	1	3
40	R:R:L280	R:R:L286	95.125	2.77	No	No	0	4	1
41	R:R:L276	R:R:L280	97.5803	2.77	No	No	0	5	4
42	R:R:L220	R:R:L276	98.7946	2.77	No	No	0	4	5
43	R:R:H272	R:R:L220	100	3.86	Yes	No	0	8	4
44	R:R:F135	R:R:H272	24.5797	2.26	Yes	Yes	1	7	8
45	L:L:?1	R:R:F135	14.1535	8.63	Yes	Yes	1	0	7
46	R:R:H272	R:R:W268	60.8976	4.23	Yes	Yes	1	8	9
47	R:R:H272	R:R:Y271	23.2942	7.62	Yes	Yes	1	8	6
48	L:L:?1	R:R:Y271	20.5631	24.93	Yes	Yes	1	0	6
49	R:R:D112	R:R:W117	10.604	8.93	No	Yes	0	5	9
50	R:R:F119	R:R:V118	10.6174	5.24	Yes	No	0	7	3
51	R:R:F189	R:R:N206	10.6174	3.62	Yes	No	0	5	4
52	R:R:F189	R:R:P185	20.919	2.89	Yes	No	0	5	7
53	R:R:D186	R:R:P185	25.9496	1.61	No	No	0	4	7
54	R:R:D186	R:R:Y205	29.2412	2.3	No	Yes	0	4	3
55	R:R:I133	R:R:W176	14.1135	2.35	Yes	Yes	0	6	9
56	R:R:C179	R:R:Y136	12.8369	2.69	No	No	0	8	6
57	R:R:M231	R:R:S146	14.7718	6.13	Yes	No	1	8	9
58	R:R:C234	R:R:S146	19.9137	1.72	No	No	1	7	9
59	R:R:C234	R:R:Y150	13.9311	5.38	No	Yes	1	7	8
60	R:R:I238	R:R:Y235	13.7087	2.42	No	Yes	0	8	8
61	R:R:I279	R:R:R216	10.6174	3.76	No	No	0	5	3
62	R:R:I238	R:R:L242	11.1334	2.85	No	No	0	8	8
63	R:R:T303	R:R:Y271	10.822	4.99	No	Yes	0	7	6
64	R:R:L286	R:R:R292	10.5151	10.93	No	Yes	6	1	3
65	R:R:F131	R:R:F135	11.5782	4.29	Yes	Yes	1	5	7
66	R:R:Y235	R:R:Y318	12.4855	4.96	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L106	R:R:Y60	2.34	1	Yes	Yes	8	8	2	2
R:R:W109	R:R:Y60	4.82	1	Yes	Yes	5	8	1	2
R:R:F131	R:R:L102	9.74	1	Yes	No	5	6	1	1
R:R:L102	R:R:N134	6.87	1	No	Yes	6	8	1	2
L:L:?1	R:R:L102	2.18	1	Yes	No	0	6	0	1
R:R:F131	R:R:T105	2.59	1	Yes	No	5	7	1	2
R:R:L106	R:R:Y308	11.72	1	Yes	No	8	6	2	1
R:R:A113	R:R:W109	2.59	0	No	Yes	5	5	2	1
R:R:S304	R:R:W109	8.65	1	No	Yes	5	5	1	1
L:L:?1	R:R:W109	3.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:G128	2.69	1	Yes	No	0	6	0	1
R:R:F131	R:R:F135	4.29	1	Yes	Yes	5	7	1	1
R:R:F131	R:R:Y308	6.19	1	Yes	No	5	6	1	1
L:L:?1	R:R:F131	28.77	1	Yes	Yes	0	5	0	1
R:R:F135	R:R:W268	8.02	1	Yes	Yes	7	9	1	1
R:R:F135	R:R:H272	2.26	1	Yes	Yes	7	8	1	2
L:L:?1	R:R:F135	8.63	1	Yes	Yes	0	7	0	1
R:R:A139	R:R:W268	2.59	0	No	Yes	8	9	2	1
R:R:F224	R:R:W268	3.01	1	Yes	Yes	8	9	2	1
R:R:F224	R:R:H272	22.63	1	Yes	Yes	8	8	2	2
R:R:F264	R:R:W268	21.05	1	Yes	Yes	9	9	2	1
R:R:H272	R:R:W268	4.23	1	Yes	Yes	8	9	2	1
R:R:H310	R:R:W268	9.52	0	No	Yes	9	9	2	1
L:L:?1	R:R:W268	6.28	1	Yes	Yes	0	9	0	1
R:R:H272	R:R:Y271	7.62	1	Yes	Yes	8	6	2	1
R:R:V275	R:R:Y271	5.05	0	No	Yes	5	6	2	1
R:R:T303	R:R:Y271	4.99	0	No	Yes	7	6	2	1
R:R:S304	R:R:Y271	2.54	1	No	Yes	5	6	1	1
L:L:?1	R:R:Y271	24.93	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S304	8.28	1	Yes	No	0	5	0	1
L:L:?1	R:R:G307	8.08	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y308	4.62	1	Yes	No	0	6	0	1
R:R:A127	R:R:G128	1.95	0	No	No	5	6	2	1
R:R:G307	R:R:L306	1.71	0	No	No	8	8	1	2
R:R:G305	R:R:W109	1.41	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Y0N_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.06
Number of Linked Nodes	254
Number of Links	290
Number of Hubs	40
Number of Links mediated by Hubs	155
Number of Communities	6
Number of Nodes involved in Communities	56
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	45532
Length Of Smallest Path	3
Average Path Length	14.633
Length of Longest Path	36
Minimum Path Strength	1.285
Average Path Strength	5.32243
Maximum Path Strength	26.85
Minimum Path Correlation	0.7
Average Path Correlation	0.924025
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	46.8876
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2178
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • protein binding • binding • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • response to stimulus • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cellular response to chemical stimulus • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • localization • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8Y0N_nogp_Chain_R P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	-	SCH546738	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

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