psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:Y60	7.03	Yes	Yes	1	8	8
2	R:R:A110	R:R:Y60	5.34	No	Yes	0	7	8
3	R:R:Y308	R:R:Y60	3.97	Yes	Yes	1	6	8
4	L:L:?1	R:R:Y60	4.77	Yes	Yes	1	0	8
5	R:R:L62	R:R:L66	6.92	No	No	0	5	6
6	R:R:C312	R:R:L63	3.17	No	No	0	8	7
7	R:R:F64	R:R:L68	6.09	No	No	0	7	6
8	R:R:F64	R:R:L106	7.31	No	Yes	1	7	8
9	R:R:F64	R:R:P107	7.22	No	No	1	7	9
10	R:R:G67	R:R:V103	3.68	No	Yes	0	8	6
11	R:R:C312	R:R:G67	3.92	No	No	0	8	8
12	R:R:L68	R:R:V103	7.45	No	Yes	0	6	6
13	R:R:G70	R:R:L69	3.42	No	No	0	7	5
14	R:R:D99	R:R:N71	14.81	No	Yes	0	9	9
15	R:R:N71	R:R:T100	5.85	Yes	No	0	9	7
16	R:R:N71	R:R:V103	2.96	Yes	Yes	0	9	6
17	R:R:N71	R:R:P315	6.52	Yes	No	0	9	9
18	R:R:L78	R:R:V74	2.98	Yes	Yes	2	7	9
19	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
20	R:R:A319	R:R:V74	3.39	No	Yes	2	7	9
21	R:R:F325	R:R:V74	6.55	Yes	Yes	2	8	9
22	R:R:F325	R:R:V77	9.18	Yes	Yes	0	8	7
23	R:R:R328	R:R:V77	3.92	Yes	Yes	0	5	7
24	R:R:M329	R:R:V77	6.09	No	Yes	0	6	7
25	R:R:L332	R:R:V77	2.98	No	Yes	0	5	7
26	R:R:D89	R:R:L78	5.43	Yes	Yes	2	8	7
27	R:R:L78	R:R:L92	4.15	Yes	No	0	7	8
28	R:R:L78	R:R:L93	4.15	Yes	No	0	7	6
29	R:R:F325	R:R:L78	6.09	Yes	Yes	2	8	7
30	R:R:L79	R:R:R82	3.64	No	No	0	4	5
31	R:R:L79	R:R:L93	5.54	No	No	0	4	6
32	R:R:L332	R:R:S80	10.51	No	No	0	5	5
33	R:R:R81	R:R:T83	15.52	No	No	0	5	6
34	R:R:D89	R:R:L85	8.14	Yes	No	2	8	6
35	R:R:L85	R:R:T90	2.95	No	No	0	6	6
36	R:R:L85	R:R:R328	4.86	No	Yes	2	6	5
37	R:R:D148	R:R:S87	10.31	Yes	No	0	8	6
38	R:R:S87	R:R:V168	3.23	No	Yes	0	6	8
39	R:R:D148	R:R:T88	8.67	Yes	No	0	8	8
40	R:R:D89	R:R:K324	4.15	Yes	No	0	8	6
41	R:R:D89	R:R:R328	3.57	Yes	Yes	2	8	5
42	R:R:T90	R:R:V168	3.17	No	Yes	0	6	8
43	R:R:C144	R:R:F91	9.78	No	Yes	0	7	7
44	R:R:F91	R:R:I145	3.77	Yes	No	0	7	9
45	R:R:D148	R:R:F91	4.78	Yes	Yes	0	8	7
46	R:R:F91	R:R:V168	7.87	Yes	Yes	0	7	8
47	R:R:F91	R:R:T171	5.19	Yes	No	0	7	5
48	R:R:C172	R:R:F91	4.19	No	Yes	0	7	7
49	R:R:C172	R:R:H94	13.27	No	No	0	7	9
50	R:R:H94	R:R:W176	7.41	No	No	0	9	9
51	R:R:L141	R:R:L95	4.15	No	No	0	8	9
52	R:R:C311	R:R:D99	10.89	No	No	0	8	9
53	R:R:L101	R:R:N134	13.73	No	No	0	5	8
54	R:R:C311	R:R:L102	4.76	No	No	0	8	6
55	R:R:L106	R:R:V103	4.47	Yes	Yes	0	8	6
56	R:R:L130	R:R:T105	2.95	No	No	0	5	7
57	R:R:L106	R:R:P107	8.21	Yes	No	1	8	9
58	R:R:L106	R:R:Y308	3.52	Yes	Yes	1	8	6
59	R:R:L108	R:R:W109	5.69	No	No	0	6	5
60	R:R:L108	R:R:W117	4.56	No	Yes	0	6	9
61	L:L:?1	R:R:W109	11.59	Yes	No	0	0	5
62	R:R:D112	R:R:W117	14.52	No	Yes	0	5	9
63	R:R:A200	R:R:Q116	4.55	No	No	0	1	3
64	R:R:Q116	R:R:T201	4.25	No	No	0	3	5
65	R:R:F119	R:R:W117	12.03	No	Yes	0	7	9
66	R:R:C124	R:R:W117	5.22	No	Yes	5	9	9
67	R:R:C203	R:R:W117	11.75	No	Yes	5	9	9
68	R:R:F119	R:R:L123	8.53	No	No	0	7	6
69	R:R:C124	R:R:C203	7.28	No	No	5	9	9
70	R:R:F187	R:R:K125	6.2	Yes	No	0	4	7
71	R:R:A129	R:R:F187	6.93	No	Yes	0	5	4
72	R:R:L130	R:R:N134	8.24	No	No	0	5	8
73	R:R:F131	R:R:N132	4.83	No	No	0	5	4
74	R:R:F131	R:R:F135	7.5	No	Yes	1	5	7
75	L:L:?1	R:R:F131	10.74	Yes	No	1	0	5
76	R:R:N132	R:R:Y136	4.65	No	Yes	0	4	6
77	R:R:D186	R:R:N132	8.08	No	No	0	4	4
78	R:R:C179	R:R:I133	4.91	No	No	0	8	6
79	R:R:I133	R:R:L180	5.71	No	No	0	6	4
80	R:R:A183	R:R:I133	3.25	No	No	0	7	6
81	R:R:F135	R:R:Y136	4.13	Yes	Yes	0	7	6
82	R:R:F135	R:R:W268	11.02	Yes	Yes	1	7	9
83	R:R:F135	R:R:H272	3.39	Yes	Yes	1	7	8
84	L:L:?1	R:R:F135	10.74	Yes	Yes	1	0	7
85	R:R:C179	R:R:Y136	4.03	No	Yes	0	8	6
86	R:R:F182	R:R:Y136	11.35	Yes	Yes	0	5	6
87	R:R:Q219	R:R:Y136	5.64	No	Yes	0	5	6
88	R:R:A137	R:R:W176	5.19	No	No	0	7	9
89	R:R:A139	R:R:P227	3.74	No	Yes	0	8	9
90	R:R:A139	R:R:W268	3.89	No	Yes	0	8	9
91	R:R:L140	R:R:V175	10.43	No	No	0	6	7
92	R:R:L142	R:R:Y318	5.86	No	Yes	0	8	9
93	R:R:A143	R:R:V230	3.39	No	No	0	7	7
94	R:R:I145	R:R:R149	5.01	No	No	3	9	9
95	R:R:I145	R:R:Y318	4.84	No	Yes	3	9	9
96	R:R:M231	R:R:S146	9.2	No	No	3	8	9
97	R:R:S146	R:R:Y235	10.17	No	Yes	3	9	8
98	R:R:F147	R:R:L151	8.53	No	Yes	0	6	5
99	R:R:D148	R:R:N152	4.04	Yes	No	0	8	8
100	R:R:D148	R:R:R167	4.76	Yes	No	0	8	4
101	R:R:R149	R:R:Y235	8.23	No	Yes	3	9	8
102	R:R:R149	R:R:Y318	5.14	No	Yes	3	9	9
103	R:R:L151	R:R:Y150	3.52	Yes	Yes	0	5	8
104	R:R:V154	R:R:Y150	11.36	No	Yes	0	7	8
105	R:R:H155	R:R:Y150	7.62	No	Yes	0	6	8
106	R:R:Y150	R:R:Y233	5.96	Yes	No	6	8	4
107	R:R:C234	R:R:Y150	6.72	No	Yes	0	7	8
108	R:R:H237	R:R:Y150	5.44	No	Yes	6	4	8
109	R:R:L151	R:R:L159	4.15	Yes	No	0	5	6
110	R:R:L151	R:R:R167	6.07	Yes	No	0	5	4
111	R:R:I153	R:R:I238	4.42	No	No	0	8	8
112	R:R:V154	R:R:V241	4.81	No	No	0	7	5
113	R:R:Q158	R:R:R161	12.85	No	No	0	4	4
114	R:R:Q158	R:R:R162	12.85	No	No	0	4	4
115	R:R:G163	R:R:L159	3.42	No	No	0	6	6
116	R:R:G163	R:R:P164	4.06	No	No	0	6	6
117	R:R:P164	R:R:R167	12.97	No	No	0	6	4
118	R:R:F182	R:R:L218	3.65	Yes	No	0	5	3
119	R:R:A183	R:R:D186	3.09	No	No	0	7	4
120	R:R:F187	R:R:L184	3.65	Yes	No	0	4	4
121	R:R:D186	R:R:F187	5.97	No	Yes	0	4	4
122	R:R:F187	R:R:I188	5.02	Yes	No	0	4	4
123	R:R:F189	R:R:I188	6.28	No	No	0	5	4
124	R:R:F189	R:R:F207	8.57	No	Yes	0	5	4
125	R:R:L190	R:R:Y205	10.55	No	No	0	5	3
126	R:R:H193	R:R:H194	19.11	Yes	No	0	3	2
127	R:R:E196	R:R:H193	11.08	No	Yes	7	1	3
128	R:R:H193	R:R:H202	5.97	Yes	No	7	3	3
129	R:R:H193	R:R:N206	14.03	Yes	No	0	3	4
130	R:R:E196	R:R:H202	7.39	No	No	7	1	3
131	R:R:H202	R:R:Q204	6.18	No	No	0	3	3
132	R:R:Q204	R:R:Y205	4.51	No	No	0	3	3
133	R:R:L215	R:R:Y205	4.69	No	No	0	5	3
134	R:R:F207	R:R:P208	4.33	Yes	No	0	4	4
135	R:R:F207	R:R:G211	3.01	Yes	No	0	4	4
136	R:R:Q209	R:R:R212	15.19	No	No	4	2	4
137	R:R:D282	R:R:Q209	3.92	Yes	No	4	2	2
138	R:R:D282	R:R:R212	5.96	Yes	No	4	2	4
139	R:R:L283	R:R:T213	7.37	No	No	0	1	1
140	R:R:Q219	R:R:R216	3.5	No	No	0	5	3
141	R:R:R216	R:R:V275	6.54	No	Yes	8	3	5
142	R:R:I279	R:R:R216	7.52	Yes	No	8	5	3
143	R:R:I279	R:R:V217	4.61	Yes	No	0	5	4
144	R:R:H272	R:R:L220	3.86	Yes	No	0	8	4
145	R:R:L220	R:R:L276	4.15	No	No	0	4	5
146	R:R:G223	R:R:P227	4.06	No	Yes	0	5	9
147	R:R:F224	R:R:L225	3.65	Yes	No	0	8	4
148	R:R:F224	R:R:L228	3.65	Yes	No	0	8	7
149	R:R:F224	R:R:T269	9.08	Yes	Yes	0	8	5
150	R:R:F224	R:R:H272	27.15	Yes	Yes	0	8	8
151	R:R:L226	R:R:P227	6.57	No	Yes	0	6	9
152	R:R:F264	R:R:L228	4.87	No	No	0	9	7
153	R:R:M231	R:R:Y235	3.59	No	Yes	3	8	8
154	R:R:F264	R:R:M231	9.95	No	No	0	9	8
155	R:R:H237	R:R:Y233	18.51	No	No	6	4	4
156	R:R:V257	R:R:Y235	8.83	No	Yes	0	7	8
157	R:R:V260	R:R:Y235	3.79	No	Yes	0	8	8
158	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
159	R:R:L239	R:R:M254	4.24	No	No	0	5	6
160	R:R:L239	R:R:V257	5.96	No	No	0	5	7
161	R:R:L239	R:R:V258	2.98	No	No	0	5	5
162	R:R:A253	R:R:L242	4.73	No	Yes	0	7	8
163	R:R:L243	R:R:M254	5.65	No	No	0	4	6
164	R:R:L251	R:R:R250	8.5	No	No	0	5	6
165	R:R:L256	R:R:R252	4.86	No	No	0	8	7
166	R:R:L256	R:R:V321	4.47	No	No	0	8	7
167	R:R:L317	R:R:V259	4.47	No	No	0	8	5
168	R:R:V260	R:R:Y318	5.05	No	Yes	0	8	9
169	R:R:F264	R:R:W268	15.03	No	Yes	0	9	9
170	R:R:C267	R:R:H310	10.32	No	No	0	9	9
171	R:R:H272	R:R:W268	5.29	Yes	Yes	1	8	9
172	R:R:H310	R:R:W268	9.52	No	Yes	0	9	9
173	L:L:?1	R:R:W268	5.41	Yes	Yes	1	0	9
174	R:R:P270	R:R:T269	5.25	No	Yes	0	9	5
175	R:R:L273	R:R:T269	2.95	No	Yes	0	6	5
176	R:R:P270	R:R:T303	3.5	No	No	0	9	7
177	R:R:L306	R:R:P270	3.28	No	No	0	8	9
178	R:R:H272	R:R:Y271	3.27	Yes	Yes	0	8	6
179	R:R:V275	R:R:Y271	8.83	Yes	Yes	0	5	6
180	R:R:T303	R:R:Y271	4.99	No	Yes	0	7	6
181	L:L:?1	R:R:Y271	12.72	Yes	Yes	0	0	6
182	R:R:I279	R:R:V275	3.07	Yes	Yes	8	5	5
183	R:R:L280	R:R:V277	4.47	No	No	0	4	5
184	R:R:D278	R:R:D282	3.99	No	Yes	0	5	2
185	R:R:I279	R:R:L283	4.28	Yes	No	0	5	1
186	R:R:D282	R:R:M281	4.16	Yes	Yes	4	2	3
187	R:R:L286	R:R:M281	5.65	No	Yes	0	1	3
188	R:R:M281	R:R:R288	6.2	Yes	No	4	3	4
189	R:R:D282	R:R:R288	3.57	Yes	No	4	2	4
190	R:R:N289	R:R:R292	4.82	No	No	0	5	3
191	R:R:G291	R:R:R295	6	No	No	0	2	3
192	R:R:S304	R:R:Y308	3.82	No	Yes	1	5	6
193	L:L:?1	R:R:S304	23.43	Yes	No	1	0	5
194	L:L:?1	R:R:G307	6.96	Yes	No	0	0	8
195	L:L:?1	R:R:Y308	22.27	Yes	Yes	1	0	6
196	R:R:H310	R:R:N314	11.48	No	No	0	9	9
197	R:R:L313	R:R:L317	5.54	No	No	0	6	8
198	R:R:N314	R:R:Y318	4.65	No	Yes	0	9	9
199	R:R:F320	R:R:L316	4.87	No	No	0	7	6
200	R:R:A319	R:R:F325	8.32	No	Yes	2	7	8
201	R:R:F320	R:R:F325	5.36	No	Yes	0	7	8
202	R:R:M329	R:R:W330	3.49	No	No	0	6	2
203	R:R:L332	R:R:R335	3.64	No	No	0	5	4
204	R:R:I238	R:R:L242	2.85	No	Yes	0	8	8
205	R:R:L242	R:R:M254	2.83	Yes	No	0	8	6
206	R:R:L306	R:R:M309	2.83	No	No	0	8	5
207	R:R:L142	R:R:L95	2.77	No	No	0	8	9
208	R:R:A222	R:R:F182	2.77	No	Yes	0	5	5
209	R:R:L276	R:R:L280	2.77	No	No	0	5	4
210	R:R:L102	R:R:N134	2.75	No	No	0	6	8
211	R:R:R250	R:R:S245	2.64	No	No	0	6	4
212	R:R:F119	R:R:V111	2.62	No	No	0	7	4
213	R:R:A192	R:R:W117	2.59	No	Yes	0	5	9
214	R:R:M281	R:R:R292	2.48	Yes	No	0	3	3
215	R:R:H155	R:R:Q158	2.47	No	No	0	6	4
216	R:R:F182	R:R:L178	2.44	Yes	No	0	5	4
217	R:R:F207	R:R:L215	2.44	Yes	No	0	4	5
218	R:R:K300	R:R:Y271	2.39	No	Yes	0	5	6
219	L:L:?1	R:R:A113	2.14	Yes	No	0	0	5
220	R:R:R328	R:R:R81	2.13	Yes	No	0	5	5
221	R:R:R292	R:R:R295	2.13	No	No	0	3	3
222	R:R:G70	R:R:P315	2.03	No	No	0	7	9
223	R:R:C290	R:R:G291	1.96	No	No	0	8	2
224	R:R:A127	R:R:G128	1.95	No	No	0	5	6
225	R:R:A137	R:R:G138	1.95	No	No	0	7	9
226	R:R:P164	R:R:P165	1.95	No	No	0	6	2
227	R:R:A214	R:R:G211	1.95	No	No	0	3	4
228	R:R:A143	R:R:P227	1.87	No	Yes	0	7	9
229	R:R:G122	R:R:S121	1.86	No	No	0	1	3
230	R:R:G291	R:R:S294	1.86	No	No	0	2	3
231	R:R:G211	R:R:V210	1.84	No	No	0	4	1
232	R:R:A137	R:R:A98	1.79	No	No	0	7	8
233	R:R:G122	R:R:K125	1.74	No	No	0	1	7
234	R:R:G67	R:R:L66	1.71	No	No	0	8	6
235	R:R:G120	R:R:L123	1.71	No	No	0	8	6
236	R:R:C144	R:R:V175	1.71	No	No	0	7	7
237	R:R:G177	R:R:L180	1.71	No	No	0	4	4
238	R:R:A114	R:R:V111	1.7	No	No	0	5	4
239	R:R:A299	R:R:V274	1.7	No	No	0	5	4
240	R:R:A192	R:R:T201	1.68	No	No	0	5	5
241	R:R:A265	R:R:T269	1.68	No	Yes	0	5	5
242	R:R:L184	R:R:P185	1.64	No	No	0	4	7
243	R:R:S86	R:R:S87	1.63	No	No	0	7	6
244	R:R:S121	R:R:S191	1.63	No	No	0	3	4
245	R:R:S294	R:R:V298	1.62	No	No	0	3	2
246	R:R:V258	R:R:V262	1.6	No	No	0	5	5
247	R:R:V274	R:R:V275	1.6	No	Yes	0	4	5
248	R:R:V274	R:R:V277	1.6	No	No	0	4	5
249	R:R:T169	R:R:V168	1.59	No	Yes	0	4	8
250	R:R:C267	R:R:L266	1.59	No	No	0	9	5
251	R:R:A127	R:R:L108	1.58	No	No	0	5	6
252	R:R:A263	R:R:L317	1.58	No	No	0	6	8
253	R:R:A285	R:R:L280	1.58	No	No	0	1	4
254	R:R:A200	R:R:N199	1.56	No	No	0	1	5
255	R:R:M281	R:R:V296	1.52	Yes	No	0	3	4
256	R:R:K300	R:R:V296	1.52	No	No	0	5	4
257	R:R:G247	R:R:R246	1.5	No	No	0	3	4
258	R:R:L123	R:R:V126	1.49	No	No	0	6	5
259	R:R:L173	R:R:T169	1.47	No	No	0	5	4
260	R:R:L170	R:R:T171	1.47	No	No	0	2	5
261	R:R:D195	R:R:T201	1.45	No	No	0	2	5
262	R:R:A84	R:R:R328	1.38	No	Yes	0	7	5
263	R:R:L313	R:R:L316	1.38	No	No	0	6	6
264	R:R:E293	R:R:M281	1.35	No	Yes	0	1	3
265	R:R:R326	R:R:V323	1.31	No	No	0	8	5
266	R:R:R161	R:R:T157	1.29	No	No	0	4	5
267	R:R:L198	R:R:R197	1.21	No	No	0	1	4
268	R:R:L242	R:R:R250	1.21	Yes	No	0	8	6
269	R:R:Q248	R:R:R249	1.17	No	No	0	3	4
270	R:R:R252	R:R:R326	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y60	5.2775	4	1	8
2	R:R:N71	7.535	4	0	9
3	R:R:V74	4.0775	4	2	9
4	R:R:V77	5.5425	4	0	7
5	R:R:L78	4.56	5	2	7
6	R:R:D89	5.3225	4	2	8
7	R:R:F91	5.93	6	0	7
8	R:R:V103	4.64	4	0	6
9	R:R:L106	6.108	5	1	8
10	R:R:W117	8.445	6	5	9
11	R:R:F135	7.356	5	1	7
12	R:R:Y136	5.96	5	0	6
13	R:R:D148	6.512	5	0	8
14	R:R:Y150	6.77	6	6	8
15	R:R:L151	5.5675	4	0	5
16	R:R:V168	3.965	4	0	8
17	R:R:F182	5.0525	4	0	5
18	R:R:F187	5.554	5	0	4
19	R:R:H193	12.5475	4	7	3
20	R:R:F207	4.5875	4	0	4
21	R:R:F224	10.8825	4	0	8
22	R:R:P227	4.06	4	0	9
23	R:R:Y235	6.61	6	3	8
24	R:R:L242	2.905	4	0	8
25	R:R:W268	8.36	6	1	9
26	R:R:T269	4.74	4	0	5
27	R:R:Y271	6.44	5	0	6
28	R:R:H272	8.592	5	1	8
29	R:R:V275	5.01	4	8	5
30	R:R:I279	4.87	4	8	5
31	R:R:M281	3.56	6	4	3
32	R:R:D282	4.32	5	4	2
33	R:R:Y308	8.395	4	1	6
34	R:R:Y318	5.108	5	3	9
35	R:R:F325	7.1	5	2	8
36	R:R:R328	3.172	5	2	5
37	L:L:?1	11.077	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:Y60	25.4572	7.03	Yes	Yes	1	8	8
2	L:L:?1	R:R:Y60	27.4561	4.77	Yes	Yes	1	0	8
3	L:L:?1	R:R:Y308	26.3491	22.27	Yes	Yes	1	0	6
4	R:R:L106	R:R:Y308	25.4572	3.52	Yes	Yes	1	8	6
5	R:R:L106	R:R:V103	42.3091	4.47	Yes	Yes	0	8	6
6	R:R:G67	R:R:V103	11.4692	3.68	No	Yes	0	8	6
7	R:R:N71	R:R:V103	27.1558	2.96	Yes	Yes	0	9	6
8	R:R:D99	R:R:N71	15.9959	14.81	No	Yes	0	9	9
9	L:L:?1	R:R:W268	71.1904	5.41	Yes	Yes	1	0	9
10	R:R:H310	R:R:W268	99.1888	9.52	No	Yes	0	9	9
11	R:R:H310	R:R:N314	97.1047	11.48	No	No	0	9	9
12	R:R:N314	R:R:Y318	96.4817	4.65	No	Yes	0	9	9
13	R:R:I145	R:R:Y318	91.0183	4.84	No	Yes	3	9	9
14	R:R:F91	R:R:I145	100	3.77	Yes	No	0	7	9
15	R:R:F91	R:R:V168	61.0389	7.87	Yes	Yes	0	7	8
16	R:R:T90	R:R:V168	58.2915	3.17	No	Yes	0	6	8
17	R:R:L85	R:R:T90	56.8932	2.95	No	No	0	6	6
18	R:R:D89	R:R:L85	27.8236	8.14	Yes	No	2	8	6
19	R:R:D89	R:R:L78	25.0762	5.43	Yes	Yes	2	8	7
20	R:R:F325	R:R:L78	12.5941	6.09	Yes	Yes	2	8	7
21	R:R:F325	R:R:V77	12.9616	9.18	Yes	Yes	0	8	7
22	R:R:R328	R:R:V77	22.0016	3.92	Yes	Yes	0	5	7
23	R:R:L85	R:R:R328	27.6398	4.86	No	Yes	2	6	5
24	R:R:D148	R:R:F91	34.3492	4.78	Yes	Yes	0	8	7
25	R:R:C311	R:R:D99	13.737	10.89	No	No	0	8	9
26	R:R:C311	R:R:L102	11.4692	4.76	No	No	0	8	6
27	L:L:?1	R:R:W109	24.3949	11.59	Yes	No	0	0	5
28	R:R:L108	R:R:W109	23.3731	5.69	No	No	0	6	5
29	R:R:L108	R:R:W117	19.8772	4.56	No	Yes	0	6	9
30	R:R:D186	R:R:F187	53.3076	5.97	No	Yes	0	4	4
31	R:R:D186	R:R:N132	56.8214	8.08	No	No	0	4	4
32	R:R:F131	R:R:N132	41.574	4.83	No	No	0	5	4
33	L:L:?1	R:R:F131	26.9138	10.74	Yes	No	1	0	5
34	R:R:F135	R:R:Y136	27.4516	4.13	Yes	Yes	0	7	6
35	R:R:H272	R:R:W268	25.0762	5.29	Yes	Yes	1	8	9
36	R:R:H272	R:R:Y271	20.9439	3.27	Yes	Yes	0	8	6
37	L:L:?1	R:R:Y271	34.5151	12.72	Yes	Yes	0	0	6
38	R:R:F264	R:R:W268	22.2033	15.03	No	Yes	0	9	9
39	R:R:F264	R:R:M231	24.7445	9.95	No	No	0	9	8
40	R:R:M231	R:R:Y235	22.9652	3.59	No	Yes	3	8	8
41	R:R:R149	R:R:Y235	11.151	8.23	No	Yes	3	9	8
42	R:R:L151	R:R:R167	24.3636	6.07	Yes	No	0	5	4
43	R:R:D148	R:R:R167	30.8265	4.76	Yes	No	0	8	4
44	R:R:L151	R:R:Y150	19.317	3.52	Yes	Yes	0	5	8
45	R:R:L242	R:R:M254	11.1106	2.83	Yes	No	0	8	6
46	R:R:L239	R:R:M254	14.239	4.24	No	No	0	5	6
47	R:R:L239	R:R:V257	18.8598	5.96	No	No	0	5	7
48	R:R:V257	R:R:Y235	20.3881	8.83	No	Yes	0	7	8
49	R:R:F187	R:R:I188	36.0255	5.02	Yes	No	0	4	4
50	R:R:F189	R:R:I188	33.8248	6.28	No	No	0	5	4
51	R:R:F189	R:R:F207	31.6153	8.57	No	Yes	0	5	4
52	R:R:F207	R:R:L215	20.4285	2.44	Yes	No	0	4	5
53	R:R:L215	R:R:Y205	18.4206	4.69	No	No	0	5	3
54	R:R:H202	R:R:Q204	11.5812	6.18	No	No	0	3	3
55	R:R:Q204	R:R:Y205	13.8715	4.51	No	No	0	3	3
56	R:R:K300	R:R:Y271	28.3749	2.39	No	Yes	0	5	6
57	R:R:K300	R:R:V296	26.8869	1.52	No	No	0	5	4
58	R:R:M281	R:R:V296	25.3854	1.52	Yes	No	0	3	4
59	R:R:V275	R:R:Y271	14.853	8.83	Yes	Yes	0	5	6
60	R:R:F224	R:R:H272	11.1778	27.15	Yes	Yes	0	8	8
61	R:R:F320	R:R:F325	19.0839	5.36	No	Yes	0	7	8
62	R:R:F320	R:R:L316	15.8659	4.87	No	No	0	7	6
63	R:R:L313	R:R:L316	12.6389	1.38	No	No	0	6	6
64	R:R:M281	R:R:R292	12.3342	2.48	Yes	No	0	3	3
65	R:R:F131	R:R:F135	16.09	7.5	No	Yes	1	5	7
66	R:R:F135	R:R:W268	35.2904	11.02	Yes	Yes	1	7	9
67	R:R:N132	R:R:Y136	17.4301	4.65	No	Yes	0	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L106	R:R:Y60	7.03	1	Yes	Yes	8	8	2	1
R:R:A110	R:R:Y60	5.34	0	No	Yes	7	8	2	1
R:R:Y308	R:R:Y60	3.97	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:Y60	4.77	1	Yes	Yes	0	8	0	1
R:R:L106	R:R:Y308	3.52	1	Yes	Yes	8	6	2	1
R:R:L108	R:R:W109	5.69	0	No	No	6	5	2	1
L:L:?1	R:R:W109	11.59	1	Yes	No	0	5	0	1
R:R:F131	R:R:N132	4.83	1	No	No	5	4	1	2
R:R:F131	R:R:F135	7.5	1	No	Yes	5	7	1	1
L:L:?1	R:R:F131	10.74	1	Yes	No	0	5	0	1
R:R:N132	R:R:Y136	4.65	0	No	Yes	4	6	2	2
R:R:F135	R:R:Y136	4.13	1	Yes	Yes	7	6	1	2
R:R:F135	R:R:W268	11.02	1	Yes	Yes	7	9	1	1
R:R:F135	R:R:H272	3.39	1	Yes	Yes	7	8	1	2
L:L:?1	R:R:F135	10.74	1	Yes	Yes	0	7	0	1
R:R:A139	R:R:W268	3.89	0	No	Yes	8	9	2	1
R:R:F264	R:R:W268	15.03	0	No	Yes	9	9	2	1
R:R:H272	R:R:W268	5.29	1	Yes	Yes	8	9	2	1
R:R:H310	R:R:W268	9.52	0	No	Yes	9	9	2	1
L:L:?1	R:R:W268	5.41	1	Yes	Yes	0	9	0	1
R:R:H272	R:R:Y271	3.27	1	Yes	Yes	8	6	2	1
R:R:V275	R:R:Y271	8.83	8	Yes	Yes	5	6	2	1
R:R:T303	R:R:Y271	4.99	0	No	Yes	7	6	2	1
L:L:?1	R:R:Y271	12.72	1	Yes	Yes	0	6	0	1
R:R:S304	R:R:Y308	3.82	1	No	Yes	5	6	1	1
L:L:?1	R:R:S304	23.43	1	Yes	No	0	5	0	1
L:L:?1	R:R:G307	6.96	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y308	22.27	1	Yes	Yes	0	6	0	1
R:R:K300	R:R:Y271	2.39	0	No	Yes	5	6	2	1
L:L:?1	R:R:A113	2.14	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HNM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	244
Number of Links	270
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	8
Number of Nodes involved in Communities	41
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	48971
Length Of Smallest Path	3
Average Path Length	13.4119
Length of Longest Path	31
Minimum Path Strength	1.19
Average Path Strength	6.23138
Maximum Path Strength	18.115
Minimum Path Correlation	0.7
Average Path Correlation	0.926575
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	51.0615
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.793
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	4IE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	4IE
Name	[4-(2-bromophenyl)phenyl]methyl-[[(1R,5S)-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl]-dimethyl-azanium
Synonyms	VUF11222
Identifier
Formula	C25 H31 Br N
Molecular Weight	425.424
SMILES
PubChem	71459295
Formal Charge	1
Total Atoms	58
Total Chiral Atoms	2
Total Bonds	61
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8HNM_nogp_Chain_R Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	-	SCH546738	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HNM_nogp.zip

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