psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L59	R:R:Y60	4.69	No	No	0	6	8
2	R:R:L62	R:R:L66	8.3	No	No	0	5	6
3	R:R:L63	R:R:Y308	3.52	No	Yes	0	7	6
4	R:R:C312	R:R:L63	3.17	No	No	0	8	7
5	R:R:F64	R:R:L65	7.31	No	No	0	7	5
6	R:R:F64	R:R:L68	3.65	No	No	0	7	6
7	R:R:F64	R:R:L106	4.87	No	Yes	0	7	8
8	R:R:C312	R:R:G67	3.92	No	No	0	8	8
9	R:R:L68	R:R:V103	5.96	No	No	0	6	6
10	R:R:D99	R:R:N71	5.39	Yes	No	0	9	9
11	R:R:N71	R:R:T100	7.31	No	No	0	9	7
12	R:R:N71	R:R:P315	4.89	No	No	0	9	9
13	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
14	R:R:P315	R:R:V74	3.53	No	Yes	0	9	9
15	R:R:A319	R:R:V74	3.39	No	Yes	4	7	9
16	R:R:F325	R:R:V74	6.55	Yes	Yes	4	8	9
17	R:R:F325	R:R:V77	9.18	Yes	No	0	8	7
18	R:R:M329	R:R:V77	3.04	No	No	0	6	7
19	R:R:L78	R:R:L92	4.15	No	No	0	7	8
20	R:R:L79	R:R:L93	5.54	No	No	0	4	6
21	R:R:L332	R:R:S80	6.01	No	No	0	5	5
22	R:R:R81	R:R:T83	7.76	No	No	0	5	6
23	R:R:L85	R:R:R81	4.86	No	No	0	6	5
24	R:R:R328	R:R:R81	9.6	No	No	0	5	5
25	R:R:A84	R:R:P165	3.74	No	No	0	7	2
26	R:R:D89	R:R:L85	8.14	No	No	0	8	6
27	R:R:D89	R:R:S86	5.89	No	No	0	8	7
28	R:R:D148	R:R:S87	4.42	No	No	0	8	6
29	R:R:S87	R:R:V168	3.23	No	Yes	0	6	8
30	R:R:T90	R:R:V168	3.17	No	Yes	0	6	8
31	R:R:C144	R:R:F91	8.38	No	No	0	7	7
32	R:R:F91	R:R:I145	3.77	No	No	0	7	9
33	R:R:F91	R:R:V168	11.8	No	Yes	0	7	8
34	R:R:A319	R:R:L92	3.15	No	No	0	7	8
35	R:R:H94	R:R:L141	3.86	No	No	0	9	8
36	R:R:C172	R:R:H94	10.32	No	No	0	7	9
37	R:R:H94	R:R:W176	6.35	No	No	0	9	9
38	R:R:D99	R:R:L95	8.14	Yes	Yes	1	9	9
39	R:R:L141	R:R:L95	4.15	No	Yes	0	8	9
40	R:R:L142	R:R:L95	5.54	No	Yes	0	8	9
41	R:R:L95	R:R:N314	6.87	Yes	No	1	9	9
42	R:R:C311	R:R:D99	7.78	No	Yes	0	8	9
43	R:R:D99	R:R:N314	10.77	Yes	No	1	9	9
44	R:R:L101	R:R:N134	9.61	No	No	0	5	8
45	R:R:F131	R:R:L102	8.53	Yes	Yes	3	5	6
46	R:R:L102	R:R:N134	9.61	Yes	No	0	6	8
47	R:R:L102	R:R:Y308	3.52	Yes	Yes	3	6	6
48	R:R:C311	R:R:L102	3.17	No	Yes	0	8	6
49	R:R:T105	R:R:Y308	6.24	No	Yes	0	7	6
50	R:R:L106	R:R:P107	4.93	Yes	No	0	8	9
51	R:R:L106	R:R:Y308	7.03	Yes	Yes	0	8	6
52	R:R:F131	R:R:W109	9.02	Yes	No	0	5	5
53	R:R:F187	R:R:V126	5.24	No	No	0	4	5
54	R:R:A129	R:R:D186	4.63	No	No	0	5	4
55	R:R:A129	R:R:F187	8.32	No	No	0	5	4
56	R:R:F131	R:R:Y308	7.22	Yes	Yes	3	5	6
57	R:R:N132	R:R:Y136	3.49	No	No	1	4	6
58	R:R:F182	R:R:N132	3.62	Yes	No	1	5	4
59	R:R:D186	R:R:N132	10.77	No	No	0	4	4
60	R:R:C179	R:R:I133	4.91	No	No	0	8	6
61	R:R:A183	R:R:I133	3.25	No	No	0	7	6
62	R:R:F135	R:R:W268	28.06	No	Yes	1	7	9
63	R:R:F135	R:R:Y271	4.13	No	Yes	1	7	6
64	R:R:F135	R:R:H272	4.53	No	Yes	1	7	8
65	R:R:F182	R:R:Y136	15.47	Yes	No	1	5	6
66	R:R:Q219	R:R:Y136	14.65	No	No	1	5	6
67	R:R:A139	R:R:P227	3.74	No	Yes	0	8	9
68	R:R:A139	R:R:W268	3.89	No	Yes	0	8	9
69	R:R:L140	R:R:V175	10.43	No	No	0	6	7
70	R:R:L141	R:R:V175	4.47	No	No	0	8	7
71	R:R:L142	R:R:M231	5.65	No	No	0	8	8
72	R:R:L142	R:R:Y318	14.07	No	No	0	8	9
73	R:R:I145	R:R:R149	5.01	No	No	0	9	9
74	R:R:M231	R:R:S146	6.13	No	No	0	8	9
75	R:R:S146	R:R:Y235	11.45	No	Yes	0	9	8
76	R:R:F147	R:R:L151	7.31	No	No	0	6	5
77	R:R:R149	R:R:Y235	7.2	No	Yes	0	9	8
78	R:R:R149	R:R:Y318	6.17	No	No	0	9	9
79	R:R:L151	R:R:Y150	3.52	No	Yes	0	5	8
80	R:R:V154	R:R:Y150	11.36	No	Yes	2	7	8
81	R:R:H155	R:R:Y150	6.53	No	Yes	2	6	8
82	R:R:Y150	R:R:Y233	3.97	Yes	No	2	8	4
83	R:R:C234	R:R:Y150	6.72	No	Yes	0	7	8
84	R:R:H237	R:R:Y150	4.36	No	Yes	2	4	8
85	R:R:L151	R:R:L159	4.15	No	No	0	5	6
86	R:R:I153	R:R:I238	4.42	No	Yes	0	8	8
87	R:R:H155	R:R:V154	8.3	No	No	2	6	7
88	R:R:V154	R:R:V241	4.81	No	No	0	7	5
89	R:R:H155	R:R:Q158	3.71	No	No	0	6	4
90	R:R:R167	R:R:T169	6.47	No	No	0	4	4
91	R:R:T171	R:R:V168	4.76	No	Yes	0	5	8
92	R:R:G177	R:R:L180	5.13	No	No	0	4	4
93	R:R:F182	R:R:L215	6.09	Yes	No	0	5	5
94	R:R:F182	R:R:L218	9.74	Yes	No	0	5	3
95	R:R:F182	R:R:Q219	3.51	Yes	No	1	5	5
96	R:R:L215	R:R:P185	9.85	No	No	0	5	7
97	R:R:G211	R:R:P208	4.06	No	No	0	4	4
98	R:R:D278	R:R:R216	7.15	No	No	5	5	3
99	R:R:I279	R:R:R216	5.01	No	No	0	5	3
100	R:R:D282	R:R:R216	3.57	No	No	5	2	3
101	R:R:Q219	R:R:Y271	6.76	No	Yes	1	5	6
102	R:R:H272	R:R:L220	3.86	Yes	No	0	8	4
103	R:R:L220	R:R:V275	2.98	No	Yes	0	4	5
104	R:R:L220	R:R:L276	5.54	No	No	0	4	5
105	R:R:G223	R:R:P227	4.06	No	Yes	0	5	9
106	R:R:F224	R:R:L228	4.87	Yes	No	1	8	7
107	R:R:F224	R:R:F264	3.22	Yes	Yes	1	8	9
108	R:R:F224	R:R:W268	9.02	Yes	Yes	1	8	9
109	R:R:F224	R:R:T269	7.78	Yes	No	0	8	5
110	R:R:F224	R:R:H272	26.02	Yes	Yes	1	8	8
111	R:R:L226	R:R:P227	6.57	No	Yes	0	6	9
112	R:R:L226	R:R:V230	2.98	No	No	0	6	7
113	R:R:F264	R:R:L228	4.87	Yes	No	1	9	7
114	R:R:F264	R:R:M231	11.2	Yes	No	0	9	8
115	R:R:H237	R:R:Y233	17.42	No	No	2	4	4
116	R:R:V257	R:R:Y235	11.36	No	Yes	0	7	8
117	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
118	R:R:L239	R:R:V257	4.47	No	No	0	5	7
119	R:R:L242	R:R:M254	4.24	No	No	0	8	6
120	R:R:L243	R:R:M254	7.07	No	No	0	4	6
121	R:R:R250	R:R:S245	10.54	Yes	No	0	6	4
122	R:R:L251	R:R:R250	3.64	No	Yes	0	5	6
123	R:R:M254	R:R:R250	4.96	No	Yes	0	6	6
124	R:R:R252	R:R:V321	3.92	No	No	0	7	7
125	R:R:L256	R:R:V321	5.96	No	No	0	8	7
126	R:R:L317	R:R:V260	2.98	No	No	0	8	8
127	R:R:V260	R:R:Y318	6.31	No	No	0	8	9
128	R:R:L266	R:R:V262	2.98	No	No	0	5	5
129	R:R:F264	R:R:W268	18.04	Yes	Yes	1	9	9
130	R:R:F264	R:R:H310	6.79	Yes	Yes	1	9	9
131	R:R:C267	R:R:L306	4.76	No	Yes	0	9	8
132	R:R:C267	R:R:H310	5.9	No	Yes	0	9	9
133	R:R:H272	R:R:W268	10.58	Yes	Yes	1	8	9
134	R:R:H310	R:R:W268	8.46	Yes	Yes	1	9	9
135	R:R:P270	R:R:T269	3.5	No	No	0	9	5
136	R:R:P270	R:R:T303	3.5	No	No	0	9	7
137	R:R:L306	R:R:P270	4.93	Yes	No	0	8	9
138	R:R:H272	R:R:Y271	11.98	Yes	Yes	1	8	6
139	R:R:V275	R:R:Y271	8.83	Yes	Yes	1	5	6
140	R:R:K300	R:R:Y271	5.97	No	Yes	1	5	6
141	R:R:T303	R:R:Y271	7.49	No	Yes	0	7	6
142	R:R:A299	R:R:V274	3.39	No	No	0	5	4
143	R:R:I279	R:R:V275	3.07	No	Yes	0	5	5
144	R:R:K300	R:R:V275	3.04	No	Yes	1	5	5
145	R:R:L276	R:R:L280	6.92	No	No	0	5	4
146	R:R:D278	R:R:D282	11.98	No	No	5	5	2
147	R:R:L286	R:R:M281	5.65	No	Yes	0	1	3
148	R:R:M281	R:R:R292	11.17	Yes	Yes	0	3	3
149	R:R:D282	R:R:R288	8.34	No	No	0	2	4
150	R:R:N289	R:R:R292	13.26	No	Yes	0	5	3
151	R:R:R292	R:R:R295	3.2	Yes	No	0	3	3
152	R:R:L306	R:R:M309	4.24	Yes	No	0	8	5
153	R:R:H310	R:R:N314	10.2	Yes	No	1	9	9
154	R:R:A319	R:R:F325	8.32	No	Yes	4	7	8
155	R:R:F320	R:R:F325	3.22	No	Yes	0	7	8
156	R:R:R326	R:R:V323	7.85	No	No	0	8	5
157	R:R:K324	R:R:R328	12.38	No	No	0	6	5
158	R:R:M329	R:R:W330	4.65	No	No	0	6	2
159	R:R:L173	R:R:T169	2.95	No	No	0	5	4
160	R:R:G305	R:R:Y60	2.9	No	No	0	5	8
161	R:R:I238	R:R:L242	2.85	Yes	No	0	8	8
162	R:R:I279	R:R:L283	2.85	No	No	0	5	1
163	R:R:E327	R:R:V323	2.85	No	No	0	5	5
164	R:R:L313	R:R:M309	2.83	No	No	0	6	5
165	R:R:L78	R:R:L93	2.77	No	No	0	7	6
166	R:R:L130	R:R:N134	2.75	No	No	0	5	8
167	R:R:F131	R:R:S304	2.64	Yes	No	0	5	5
168	R:R:A98	R:R:W176	2.59	No	No	0	8	9
169	R:R:M281	R:R:R288	2.48	Yes	No	0	3	4
170	R:R:M331	R:R:R328	2.48	No	No	0	4	5
171	R:R:F224	R:R:L225	2.44	Yes	No	0	8	4
172	R:R:I238	R:R:Y150	2.42	Yes	Yes	0	8	8
173	R:R:I238	R:R:Y235	2.42	Yes	Yes	0	8	8
174	R:R:I133	R:R:W176	2.35	No	No	0	6	9
175	R:R:C290	R:R:G291	1.96	No	No	0	8	2
176	R:R:A75	R:R:G72	1.95	No	No	0	7	4
177	R:R:A127	R:R:G128	1.95	No	No	0	5	6
178	R:R:A143	R:R:P227	1.87	No	Yes	0	7	9
179	R:R:A75	R:R:A96	1.79	No	No	0	7	9
180	R:R:A137	R:R:A98	1.79	No	No	0	7	8
181	R:R:G67	R:R:L66	1.71	No	No	0	8	6
182	R:R:G70	R:R:L69	1.71	No	No	0	7	5
183	R:R:A166	R:R:S87	1.71	No	No	0	4	6
184	R:R:G138	R:R:L95	1.71	No	Yes	0	9	9
185	R:R:G307	R:R:L306	1.71	No	Yes	0	8	8
186	R:R:G291	R:R:N289	1.7	No	No	0	2	5
187	R:R:A265	R:R:T269	1.68	No	No	0	5	5
188	R:R:L108	R:R:P107	1.64	No	No	0	6	9
189	R:R:L184	R:R:P185	1.64	No	No	0	4	7
190	R:R:A73	R:R:M329	1.61	No	No	0	7	6
191	R:R:V217	R:R:V221	1.6	No	No	0	4	5
192	R:R:V258	R:R:V262	1.6	No	No	0	5	5
193	R:R:V274	R:R:V296	1.6	No	No	0	4	4
194	R:R:A110	R:R:L106	1.58	No	Yes	0	7	8
195	R:R:A127	R:R:L108	1.58	No	No	0	5	6
196	R:R:A222	R:R:L218	1.58	No	No	0	5	3
197	R:R:A253	R:R:L242	1.58	No	No	0	7	8
198	R:R:A263	R:R:L317	1.58	No	No	0	6	8
199	R:R:A285	R:R:L280	1.58	No	No	0	1	4
200	R:R:M281	R:R:V277	1.52	Yes	No	0	3	5
201	R:R:G247	R:R:R250	1.5	No	Yes	0	3	6
202	R:R:G322	R:R:R326	1.5	No	No	0	8	8
203	R:R:L332	R:R:V77	1.49	No	No	0	5	7
204	R:R:L239	R:R:V258	1.49	No	No	0	5	5
205	R:R:L256	R:R:V260	1.49	No	No	0	8	8
206	R:R:L317	R:R:V259	1.49	No	No	0	8	5
207	R:R:L273	R:R:V277	1.49	No	No	0	6	5
208	R:R:L85	R:R:T90	1.47	No	No	0	6	6
209	R:R:D89	R:R:T88	1.45	No	No	0	8	8
210	R:R:G305	R:R:Y308	1.45	No	Yes	0	5	6
211	R:R:P208	R:R:R212	1.44	No	No	0	4	4
212	R:R:I188	R:R:L184	1.43	No	No	0	4	4
213	R:R:I153	R:R:N152	1.42	No	No	0	8	8
214	R:R:Q209	R:R:T213	1.42	No	No	0	2	1
215	R:R:A166	R:R:R161	1.38	No	No	0	4	4
216	R:R:L178	R:R:L181	1.38	No	No	0	4	5
217	R:R:L313	R:R:L316	1.38	No	No	0	6	6
218	R:R:E327	R:R:K324	1.35	No	No	0	5	6
219	R:R:R292	R:R:V296	1.31	Yes	No	0	3	4
220	R:R:R82	R:R:T83	1.29	No	No	0	5	6
221	R:R:R167	R:R:T90	1.29	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V74	4.215	4	4	9
2	R:R:L95	5.282	5	1	9
3	R:R:D99	8.02	4	1	9
4	R:R:L102	6.2075	4	3	6
5	R:R:L106	4.6025	4	0	8
6	R:R:F131	6.8525	4	3	5
7	R:R:Y150	5.55429	7	2	8
8	R:R:V168	5.74	4	0	8
9	R:R:F182	7.686	5	1	5
10	R:R:F224	8.89167	6	1	8
11	R:R:P227	4.06	4	0	9
12	R:R:Y235	7.496	5	0	8
13	R:R:I238	3.0275	4	0	8
14	R:R:R250	5.16	4	0	6
15	R:R:F264	8.824	5	1	9
16	R:R:W268	13.0083	6	1	9
17	R:R:Y271	7.52667	6	1	6
18	R:R:H272	11.394	5	1	8
19	R:R:V275	4.48	4	1	5
20	R:R:M281	5.205	4	0	3
21	R:R:R292	7.235	4	0	3
22	R:R:L306	3.91	4	0	8
23	R:R:Y308	4.83	6	3	6
24	R:R:H310	7.8375	4	1	9
25	R:R:F325	6.8175	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:Y308	15.2721	7.03	Yes	Yes	0	8	6
2	R:R:C311	R:R:D99	40.0507	7.78	No	Yes	0	8	9
3	R:R:C311	R:R:L102	38.7659	3.17	No	Yes	0	8	6
4	R:R:L102	R:R:Y308	29.146	3.52	Yes	Yes	3	6	6
5	R:R:D99	R:R:N71	29.2647	5.39	Yes	No	0	9	9
6	R:R:N71	R:R:P315	26.5116	4.89	No	No	0	9	9
7	R:R:P315	R:R:V74	25.1188	3.53	No	Yes	0	9	9
8	R:R:F325	R:R:V74	11.9467	6.55	Yes	Yes	4	8	9
9	R:R:D99	R:R:L95	29.0164	8.14	Yes	Yes	1	9	9
10	R:R:L142	R:R:L95	34.6577	5.54	No	Yes	0	8	9
11	R:R:L142	R:R:Y318	61.1747	14.07	No	No	0	8	9
12	R:R:R149	R:R:Y318	52.154	6.17	No	No	0	9	9
13	R:R:I145	R:R:R149	72.1442	5.01	No	No	0	9	9
14	R:R:F91	R:R:I145	69.6286	3.77	No	No	0	7	9
15	R:R:F91	R:R:V168	64.4785	11.8	No	Yes	0	7	8
16	R:R:T90	R:R:V168	48.9797	3.17	No	Yes	0	6	8
17	R:R:L85	R:R:T90	38.2909	1.47	No	No	0	6	6
18	R:R:L85	R:R:R81	27.4239	4.86	No	No	0	6	5
19	R:R:R328	R:R:R81	19.4019	9.6	No	No	0	5	5
20	R:R:S87	R:R:V168	11.0343	3.23	No	Yes	0	6	8
21	R:R:H94	R:R:L141	12.4163	3.86	No	No	0	9	8
22	R:R:L141	R:R:L95	16.951	4.15	No	Yes	0	8	9
23	R:R:D99	R:R:N314	35.3109	10.77	Yes	No	1	9	9
24	R:R:A129	R:R:F187	10.5215	8.32	No	No	0	5	4
25	R:R:A129	R:R:D186	15.7687	4.63	No	No	0	5	4
26	R:R:D186	R:R:N132	21.0052	10.77	No	No	0	4	4
27	R:R:N132	R:R:Y136	13.0317	3.49	No	No	1	4	6
28	R:R:Q219	R:R:Y136	15.5798	14.65	No	No	1	5	6
29	R:R:Q219	R:R:Y271	48.8339	6.76	No	Yes	1	5	6
30	R:R:F135	R:R:Y271	37.1788	4.13	No	Yes	1	7	6
31	R:R:F135	R:R:W268	37.9346	28.06	No	Yes	1	7	9
32	R:R:H310	R:R:W268	41.5353	8.46	Yes	Yes	1	9	9
33	R:R:H310	R:R:N314	46.599	10.2	Yes	No	1	9	9
34	R:R:F182	R:R:N132	13.1937	3.62	Yes	No	1	5	4
35	R:R:F182	R:R:Q219	30.9382	3.51	Yes	No	1	5	5
36	R:R:H272	R:R:Y271	60.1544	11.98	Yes	Yes	1	8	6
37	R:R:H272	R:R:W268	58.821	10.58	Yes	Yes	1	8	9
38	R:R:L142	R:R:M231	49.6383	5.65	No	No	0	8	8
39	R:R:M231	R:R:S146	70.8864	6.13	No	No	0	8	9
40	R:R:S146	R:R:Y235	69.7905	11.45	No	Yes	0	9	8
41	R:R:R149	R:R:Y235	44.715	7.2	No	Yes	0	9	8
42	R:R:I238	R:R:Y150	22.4843	2.42	Yes	Yes	0	8	8
43	R:R:I238	R:R:Y235	43.2628	2.42	Yes	Yes	0	8	8
44	R:R:F182	R:R:L215	10.5755	6.09	Yes	No	0	5	5
45	R:R:I279	R:R:R216	64.2896	5.01	No	No	0	5	3
46	R:R:I279	R:R:V275	72.2252	3.07	No	Yes	0	5	5
47	R:R:L220	R:R:V275	28.6277	2.98	No	Yes	0	4	5
48	R:R:H272	R:R:L220	34.3662	3.86	Yes	No	0	8	4
49	R:R:V275	R:R:Y271	48.4992	8.83	Yes	Yes	1	5	6
50	R:R:D282	R:R:R216	56.6616	3.57	No	No	5	2	3
51	R:R:F224	R:R:F264	38.5662	3.22	Yes	Yes	1	8	9
52	R:R:V257	R:R:Y235	10.2084	11.36	No	Yes	0	7	8
53	R:R:I238	R:R:L242	16.1466	2.85	Yes	No	0	8	8
54	R:R:L242	R:R:M254	12.249	4.24	No	No	0	8	6
55	R:R:V260	R:R:Y318	12.2328	6.31	No	No	0	8	9
56	R:R:R292	R:R:V296	12.3731	1.31	Yes	No	0	3	4
57	R:R:M281	R:R:R292	32.8007	11.17	Yes	Yes	0	3	3
58	R:R:M281	R:R:R288	48.9419	2.48	Yes	No	0	3	4
59	R:R:D282	R:R:R288	52.7424	8.34	No	No	0	2	4
60	R:R:N289	R:R:R292	12.3839	13.26	No	Yes	0	5	3
61	R:R:K324	R:R:R328	14.0844	12.38	No	No	0	6	5
62	R:R:E327	R:R:K324	11.2881	1.35	No	No	0	5	6
63	R:R:L95	R:R:N314	11.2557	6.87	Yes	No	1	9	9
64	R:R:F264	R:R:W268	58.8912	18.04	Yes	Yes	1	9	9
65	R:R:F264	R:R:M231	100	11.2	Yes	No	0	9	8
66	R:R:F224	R:R:H272	35.6834	26.02	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XXY

PDB Summary
PDB	8XXY
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR3
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.68
Date	2025-02-26
D.O.I.	doi.org/10.1038/s41467-025-58264-w

Net Summary
I_min	2.98
Number of Linked Nodes	209
Number of Links	221
Number of Hubs	25
Number of Links mediated by Hubs	98
Number of Communities	5
Number of Nodes involved in Communities	31
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	40458
Length Of Smallest Path	3
Average Path Length	14.1525
Length of Longest Path	30
Minimum Path Strength	1.38
Average Path Strength	7.01286
Maximum Path Strength	23.05
Minimum Path Correlation	0.7
Average Path Correlation	0.919057
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	41.2885
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.7322
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • protein binding • binding • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • response to stimulus • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cellular response to chemical stimulus • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • intracellular anatomical structure • cytoplasm
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8XXY_Chain_R L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R P A R V T L T C L A V W G L C L L F A L P D F I P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XXY.zip

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