psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P41	R:R:S40	5.34	No	No	0	3	4
2	L:L:R52	R:R:S40	9.22	No	No	0	0	4
3	L:L:I42	R:R:P42	6.77	Yes	Yes	0	0	7
4	L:L:Q51	R:R:P42	4.74	No	Yes	2	0	7
5	R:R:C290	R:R:C43	5.46	No	No	0	8	9
6	L:L:I12	R:R:C43	3.27	No	No	0	0	9
7	R:R:D46	R:R:P44	3.22	No	No	0	4	2
8	R:R:F47	R:R:F51	3.22	No	Yes	0	1	5
9	R:R:F47	R:R:S294	5.28	No	No	0	1	3
10	R:R:L49	R:R:S48	6.01	Yes	No	0	3	4
11	R:R:D297	R:R:S48	7.36	No	No	0	4	4
12	R:R:L49	R:R:R53	3.64	Yes	No	0	3	3
13	R:R:F51	R:R:F55	18.22	Yes	No	0	5	4
14	R:R:D52	R:R:L56	10.86	No	Yes	4	5	5
15	R:R:A113	R:R:D52	4.63	No	No	4	5	5
16	L:L:K5	R:R:D52	4.15	No	No	0	0	5
17	R:R:L56	R:R:Y60	10.55	Yes	Yes	0	5	8
18	R:R:A113	R:R:L56	3.15	No	Yes	4	5	5
19	R:R:L56	R:R:S301	6.01	Yes	No	0	5	4
20	R:R:L59	R:R:L63	4.15	No	No	0	6	7
21	R:R:L106	R:R:Y60	11.72	No	Yes	0	8	8
22	R:R:A110	R:R:Y60	4	No	Yes	0	7	8
23	R:R:Y308	R:R:Y60	4.96	No	Yes	0	6	8
24	R:R:C312	R:R:L63	3.17	No	No	0	8	7
25	R:R:F64	R:R:L68	8.53	No	No	0	7	6
26	R:R:F64	R:R:P107	11.56	No	No	0	7	9
27	R:R:G67	R:R:V103	5.52	No	No	0	8	6
28	R:R:C312	R:R:G67	3.92	No	No	0	8	8
29	R:R:G70	R:R:L69	3.42	No	No	0	7	5
30	R:R:D99	R:R:N71	6.73	Yes	No	0	9	9
31	R:R:N71	R:R:T100	5.85	No	No	0	9	7
32	R:R:N71	R:R:P315	9.77	No	No	0	9	9
33	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
34	R:R:P315	R:R:V74	3.53	No	Yes	0	9	9
35	R:R:A319	R:R:V74	3.39	No	Yes	5	7	9
36	R:R:F325	R:R:V74	6.55	Yes	Yes	5	8	9
37	R:R:F325	R:R:V77	9.18	Yes	No	0	8	7
38	R:R:M329	R:R:V77	4.56	No	No	0	6	7
39	R:R:D89	R:R:L78	5.43	Yes	No	0	8	7
40	R:R:F325	R:R:L78	6.09	Yes	No	0	8	7
41	R:R:L332	R:R:S80	4.5	No	No	0	5	5
42	R:R:R81	R:R:T83	9.06	Yes	No	0	5	6
43	R:R:D89	R:R:L85	5.43	Yes	No	6	8	6
44	R:R:L85	R:R:R328	3.64	No	No	6	6	5
45	R:R:D89	R:R:S86	8.83	Yes	No	0	8	7
46	R:R:D148	R:R:S87	8.83	Yes	No	0	8	6
47	R:R:S87	R:R:V168	3.23	No	No	0	6	8
48	R:R:D148	R:R:T88	7.23	Yes	No	0	8	8
49	R:R:D89	R:R:R328	4.76	Yes	No	6	8	5
50	R:R:T90	R:R:V168	4.76	No	No	0	6	8
51	R:R:C144	R:R:F91	4.19	No	Yes	0	7	7
52	R:R:F91	R:R:I145	3.77	Yes	No	0	7	9
53	R:R:D148	R:R:F91	4.78	Yes	Yes	0	8	7
54	R:R:F91	R:R:V168	5.24	Yes	No	0	7	8
55	R:R:F91	R:R:T171	6.49	Yes	No	0	7	5
56	R:R:C172	R:R:F91	4.19	No	Yes	0	7	7
57	R:R:A319	R:R:L92	3.15	No	No	0	7	8
58	R:R:C172	R:R:H94	13.27	No	No	0	7	9
59	R:R:H94	R:R:W176	7.41	No	No	0	9	9
60	R:R:D99	R:R:L95	6.79	Yes	Yes	1	9	9
61	R:R:L141	R:R:L95	4.15	No	Yes	0	8	9
62	R:R:L142	R:R:L95	4.15	No	Yes	0	8	9
63	R:R:L95	R:R:N314	4.12	Yes	No	1	9	9
64	R:R:C311	R:R:D99	4.67	No	Yes	0	8	9
65	R:R:D99	R:R:N314	5.39	Yes	No	1	9	9
66	R:R:L101	R:R:N134	8.24	No	No	0	5	8
67	R:R:F131	R:R:L102	8.53	Yes	No	0	5	6
68	R:R:L102	R:R:N134	8.24	No	No	0	6	8
69	R:R:C311	R:R:L102	3.17	No	No	0	8	6
70	R:R:T105	R:R:W109	6.06	No	Yes	0	7	5
71	R:R:L130	R:R:T105	4.42	No	No	0	5	7
72	R:R:L106	R:R:P107	3.28	No	No	0	8	9
73	R:R:A127	R:R:W109	3.89	No	Yes	0	5	5
74	L:L:P2	R:R:W109	13.51	No	Yes	1	0	5
75	L:L:M3	R:R:W109	9.31	Yes	Yes	1	0	5
76	R:R:F119	R:R:V111	6.55	Yes	No	0	7	4
77	R:R:D112	R:R:W117	10.05	No	Yes	0	5	9
78	R:R:D112	R:R:H202	10.08	No	No	0	5	3
79	R:R:Q116	R:R:V115	7.16	No	No	0	3	4
80	R:R:F119	R:R:W117	14.03	Yes	Yes	0	7	9
81	R:R:C124	R:R:W117	3.92	No	Yes	1	9	9
82	R:R:C203	R:R:W117	5.22	No	Yes	1	9	9
83	R:R:F119	R:R:V118	3.93	Yes	No	0	7	3
84	R:R:F119	R:R:L123	6.09	Yes	No	0	7	6
85	R:R:C124	R:R:L190	3.17	No	No	1	9	5
86	R:R:C124	R:R:C203	7.28	No	No	1	9	9
87	R:R:D186	R:R:G128	5.03	Yes	No	0	4	6
88	L:L:M3	R:R:G128	5.24	Yes	No	0	0	6
89	R:R:A129	R:R:F187	5.55	No	No	0	5	4
90	R:R:F131	R:R:Y308	7.22	Yes	No	0	5	6
91	L:L:F1	R:R:F131	12.86	Yes	Yes	1	0	5
92	L:L:P2	R:R:F131	4.33	No	Yes	1	0	5
93	L:L:M3	R:R:F131	4.98	Yes	Yes	1	0	5
94	R:R:D186	R:R:N132	8.08	Yes	No	1	4	4
95	R:R:N132	R:R:Y205	3.49	No	Yes	1	4	3
96	R:R:N132	R:R:Q219	3.96	No	Yes	1	4	5
97	R:R:I133	R:R:L180	4.28	No	No	0	6	4
98	R:R:A183	R:R:I133	3.25	No	No	0	7	6
99	R:R:F135	R:R:G223	3.01	No	No	0	7	5
100	R:R:F135	R:R:W268	6.01	No	Yes	0	7	9
101	L:L:F1	R:R:F135	11.79	Yes	No	0	0	7
102	R:R:F182	R:R:Y136	10.32	Yes	No	0	5	6
103	R:R:Q219	R:R:Y136	4.51	Yes	No	0	5	6
104	R:R:A137	R:R:W176	5.19	No	No	0	7	9
105	R:R:L140	R:R:V175	4.47	No	No	0	6	7
106	R:R:L142	R:R:Y318	5.86	No	Yes	0	8	9
107	R:R:A143	R:R:V230	3.39	No	No	0	7	7
108	R:R:I145	R:R:R149	3.76	No	No	1	9	9
109	R:R:I145	R:R:Y318	6.04	No	Yes	1	9	9
110	R:R:M231	R:R:S146	6.13	No	No	1	8	9
111	R:R:C234	R:R:S146	3.44	No	No	0	7	9
112	R:R:S146	R:R:Y235	10.17	No	Yes	1	9	8
113	R:R:F147	R:R:L151	6.09	No	No	0	6	5
114	R:R:D148	R:R:N152	5.39	Yes	No	0	8	8
115	R:R:D148	R:R:R167	4.76	Yes	No	0	8	4
116	R:R:R149	R:R:Y235	8.23	No	Yes	1	9	8
117	R:R:R149	R:R:Y318	5.14	No	Yes	1	9	9
118	R:R:V154	R:R:Y150	11.36	No	No	0	7	8
119	R:R:C234	R:R:Y150	8.06	No	No	0	7	8
120	R:R:H237	R:R:Y150	5.44	No	No	0	4	8
121	R:R:L151	R:R:R167	4.86	No	No	0	5	4
122	R:R:H155	R:R:V154	4.15	No	No	0	6	7
123	R:R:V154	R:R:V241	3.21	No	No	0	7	5
124	R:R:Q158	R:R:R162	4.67	No	No	0	4	4
125	R:R:G163	R:R:L159	3.42	No	No	0	6	6
126	R:R:L159	R:R:R167	3.64	No	No	0	6	4
127	R:R:R161	R:R:R162	8.53	No	No	0	4	4
128	R:R:G163	R:R:P164	4.06	No	No	0	6	6
129	R:R:F182	R:R:L178	9.74	Yes	No	0	5	4
130	R:R:F182	R:R:L218	3.65	Yes	No	0	5	3
131	R:R:L184	R:R:P185	3.28	No	No	0	4	7
132	R:R:D186	R:R:L190	9.5	Yes	No	1	4	5
133	R:R:D186	R:R:Y205	13.79	Yes	Yes	1	4	3
134	R:R:F189	R:R:I188	7.54	No	No	0	5	4
135	R:R:F189	R:R:F207	10.72	No	Yes	0	5	4
136	R:R:L190	R:R:Y205	8.21	No	Yes	1	5	3
137	R:R:N206	R:R:S191	8.94	No	No	0	4	4
138	R:R:H193	R:R:Q204	6.18	No	No	0	3	3
139	R:R:E196	R:R:H194	9.85	No	No	0	1	2
140	R:R:H194	R:R:T201	5.48	No	No	0	2	5
141	R:R:D195	R:R:L198	4.07	No	No	0	2	1
142	R:R:D195	R:R:Q204	14.36	No	No	0	2	3
143	L:L:G7	R:R:R197	3	No	Yes	0	0	4
144	L:L:L10	R:R:R197	3.64	No	Yes	3	0	4
145	L:L:M30	R:R:R197	11.17	No	Yes	3	0	4
146	L:L:S33	R:R:R197	3.95	No	Yes	0	0	4
147	L:L:C36	R:R:R197	6.96	No	Yes	0	0	4
148	L:L:E40	R:R:R197	17.45	Yes	Yes	3	0	4
149	L:L:K5	R:R:H202	5.24	No	No	0	0	3
150	R:R:F207	R:R:Y205	11.35	Yes	Yes	1	4	3
151	R:R:L215	R:R:Y205	4.69	No	Yes	1	5	3
152	L:L:M3	R:R:Y205	5.99	Yes	Yes	1	0	3
153	L:L:F4	R:R:Y205	3.09	Yes	Yes	1	0	3
154	R:R:F207	R:R:G211	4.52	Yes	No	0	4	4
155	R:R:F207	R:R:L215	3.65	Yes	No	1	4	5
156	L:L:N34	R:R:P208	3.26	No	No	0	0	4
157	R:R:D282	R:R:Q209	6.53	No	No	1	2	2
158	L:L:R6	R:R:Q209	5.84	Yes	No	1	0	2
159	L:L:F4	R:R:R212	4.28	Yes	No	1	0	4
160	L:L:R6	R:R:R212	17.06	Yes	No	1	0	4
161	L:L:N35	R:R:R212	10.85	No	No	1	0	4
162	L:L:F4	R:R:L215	4.87	Yes	No	1	0	5
163	R:R:R216	R:R:V275	3.92	Yes	No	1	3	5
164	R:R:D278	R:R:R216	3.57	No	Yes	0	5	3
165	R:R:I279	R:R:R216	7.52	No	Yes	1	5	3
166	L:L:F4	R:R:R216	11.76	Yes	Yes	1	0	3
167	L:L:F1	R:R:Q219	11.71	Yes	Yes	1	0	5
168	L:L:F4	R:R:Q219	8.2	Yes	Yes	1	0	5
169	R:R:H272	R:R:L220	5.14	Yes	No	0	8	4
170	R:R:F224	R:R:L225	3.65	Yes	No	0	8	4
171	R:R:F224	R:R:L228	3.65	Yes	No	0	8	7
172	R:R:F224	R:R:T269	5.19	Yes	No	0	8	5
173	R:R:F224	R:R:H272	16.97	Yes	Yes	0	8	8
174	R:R:L226	R:R:P227	4.93	No	No	0	6	9
175	R:R:F264	R:R:L228	3.65	Yes	No	0	9	7
176	R:R:M231	R:R:Y235	3.59	No	Yes	1	8	8
177	R:R:F264	R:R:M231	6.22	Yes	No	1	9	8
178	R:R:H237	R:R:Y233	13.07	No	No	0	4	4
179	R:R:I238	R:R:Y235	3.63	No	Yes	0	8	8
180	R:R:V257	R:R:Y235	8.83	No	Yes	0	7	8
181	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
182	R:R:L239	R:R:V257	5.96	No	No	0	5	7
183	R:R:L242	R:R:M254	4.24	No	Yes	0	8	6
184	R:R:L251	R:R:R250	4.86	No	No	7	5	6
185	R:R:M254	R:R:R250	3.72	Yes	No	7	6	6
186	R:R:L251	R:R:M254	4.24	No	Yes	7	5	6
187	R:R:L251	R:R:R255	4.86	No	No	0	5	5
188	R:R:L256	R:R:V321	7.45	No	No	0	8	7
189	R:R:L317	R:R:V260	4.47	No	No	1	8	8
190	R:R:V260	R:R:Y318	3.79	No	Yes	1	8	9
191	R:R:F264	R:R:W268	7.02	Yes	Yes	1	9	9
192	R:R:F264	R:R:H310	7.92	Yes	Yes	1	9	9
193	R:R:C267	R:R:H310	10.32	No	Yes	0	9	9
194	R:R:W268	R:R:Y271	5.79	Yes	Yes	1	9	6
195	R:R:H272	R:R:W268	4.23	Yes	Yes	1	8	9
196	R:R:G307	R:R:W268	8.44	No	Yes	0	8	9
197	R:R:H310	R:R:W268	7.41	Yes	Yes	1	9	9
198	R:R:P270	R:R:T269	8.74	No	No	0	9	5
199	R:R:P270	R:R:T303	3.5	No	No	0	9	7
200	R:R:H272	R:R:Y271	3.27	Yes	Yes	1	8	6
201	R:R:V275	R:R:Y271	6.31	No	Yes	1	5	6
202	R:R:T303	R:R:Y271	6.24	No	Yes	0	7	6
203	L:L:F1	R:R:Y271	12.38	Yes	Yes	1	0	6
204	R:R:A299	R:R:V274	3.39	No	No	0	5	4
205	R:R:K300	R:R:V274	4.55	No	No	0	5	4
206	R:R:T303	R:R:V274	4.76	No	No	0	7	4
207	R:R:I279	R:R:V275	3.07	No	No	1	5	5
208	R:R:L276	R:R:L280	5.54	No	No	0	5	4
209	R:R:D278	R:R:V296	5.84	No	No	0	5	4
210	R:R:D278	R:R:K300	9.68	No	No	0	5	5
211	R:R:M281	R:R:R292	4.96	No	No	0	3	3
212	R:R:E293	R:R:M281	5.41	No	No	0	1	3
213	R:R:D282	R:R:L283	5.43	No	No	0	2	1
214	L:L:R6	R:R:D282	3.57	Yes	No	1	0	2
215	R:R:A287	R:R:R292	6.91	No	No	0	1	3
216	R:R:E293	R:R:R288	10.47	No	No	0	1	4
217	L:L:I12	R:R:R288	6.26	No	No	0	0	4
218	R:R:N289	R:R:R292	3.62	No	No	0	5	3
219	R:R:G291	R:R:R295	4.5	No	No	0	2	3
220	L:L:R8	R:R:E293	12.79	No	No	0	0	1
221	R:R:S304	R:R:Y308	11.45	No	No	0	5	6
222	R:R:H310	R:R:N314	15.31	Yes	No	1	9	9
223	R:R:L317	R:R:Y318	4.69	No	Yes	1	8	9
224	R:R:A319	R:R:F325	8.32	No	Yes	5	7	8
225	R:R:F320	R:R:F325	6.43	No	Yes	0	7	8
226	R:R:E327	R:R:W330	6.54	No	No	0	5	2
227	R:R:M329	R:R:W330	6.98	No	No	0	6	2
228	R:R:L334	R:R:W330	4.56	No	No	0	3	2
229	R:R:L333	R:R:L334	4.15	No	No	0	6	3
230	R:R:L336	R:R:R335	7.29	No	No	0	4	4
231	L:L:F1	L:L:F4	3.22	Yes	Yes	1	0	0
232	L:L:M3	L:L:P2	6.71	Yes	No	1	0	0
233	L:L:G7	L:L:R6	3	No	Yes	0	0	0
234	L:L:N35	L:L:R6	21.69	No	Yes	1	0	0
235	L:L:C36	L:L:C9	7.28	No	No	0	0	0
236	L:L:E40	L:L:L10	6.63	Yes	No	3	0	0
237	L:L:C11	L:L:E40	4.56	No	Yes	0	0	0
238	L:L:C11	L:L:C53	7.28	No	No	0	0	0
239	L:L:G13	L:L:P14	4.06	No	No	0	0	0
240	L:L:G15	L:L:N55	5.09	No	Yes	0	0	0
241	L:L:R52	L:L:V16	15.69	No	No	0	0	0
242	L:L:K17	L:L:S58	6.12	No	No	8	0	0
243	L:L:K17	L:L:Q60	5.42	No	No	8	0	0
244	L:L:A18	L:L:R52	4.15	No	No	0	0	0
245	L:L:D23	L:L:K20	15.21	No	No	0	0	0
246	L:L:D23	L:L:L45	5.43	No	No	0	0	0
247	L:L:E25	L:L:T44	5.64	No	Yes	0	0	0
248	L:L:I42	L:L:K26	4.36	Yes	No	0	0	0
249	L:L:K26	L:L:T44	12.01	No	Yes	2	0	0
250	L:L:K26	L:L:Q51	13.56	No	No	2	0	0
251	L:L:A27	L:L:I43	3.25	No	No	0	0	0
252	L:L:I42	L:L:S28	3.1	Yes	No	0	0	0
253	L:L:I29	L:L:V41	4.61	Yes	No	0	0	0
254	L:L:I29	L:L:I64	4.42	Yes	No	0	0	0
255	L:L:I29	L:L:I65	4.42	Yes	No	0	0	0
256	L:L:I29	L:L:V68	12.29	Yes	No	0	0	0
257	L:L:E40	L:L:M30	8.12	Yes	No	3	0	0
258	L:L:P32	L:L:Y31	4.17	No	No	0	0	0
259	L:L:I39	L:L:P32	6.77	No	No	0	0	0
260	L:L:K38	L:L:P56	5.02	No	No	0	0	0
261	L:L:I39	L:L:I65	4.42	No	No	0	0	0
262	L:L:I43	L:L:V41	3.07	No	No	0	0	0
263	L:L:L54	L:L:V41	4.47	No	No	0	0	0
264	L:L:C53	L:L:I42	3.27	No	Yes	0	0	0
265	L:L:N48	L:L:T44	5.85	No	Yes	0	0	0
266	L:L:Q51	L:L:T44	4.25	No	Yes	2	0	0
267	L:L:E47	L:L:K49	10.8	No	No	0	0	0
268	L:L:L54	L:L:Q60	7.99	No	No	0	0	0
269	L:L:A61	L:L:L54	3.15	No	No	0	0	0
270	L:L:K57	L:L:N55	6.99	No	Yes	0	0	0
271	L:L:Q60	L:L:S58	10.11	No	No	8	0	0
272	L:L:K59	L:L:R62	8.66	No	No	0	0	0
273	L:L:K66	L:L:L63	4.23	No	No	0	0	0
274	L:L:K67	L:L:L63	7.05	No	No	0	0	0
275	L:L:I64	L:L:K67	5.82	No	No	0	0	0
276	L:L:K67	L:L:K71	5.75	No	No	0	0	0
277	L:L:E69	L:L:R70	10.47	No	No	0	0	0
278	R:R:L68	R:R:V103	2.98	No	No	0	6	6
279	R:R:L141	R:R:V175	2.98	No	No	0	8	7
280	R:R:L239	R:R:V258	2.98	No	No	0	5	5
281	R:R:L266	R:R:V262	2.98	No	No	0	5	5
282	R:R:L273	R:R:T269	2.95	No	No	0	6	5
283	R:R:I153	R:R:I238	2.94	No	No	0	8	8
284	R:R:A200	R:R:H202	2.93	No	No	0	1	3
285	R:R:Q45	R:R:S48	2.89	No	No	0	4	4
286	R:R:I238	R:R:L242	2.85	No	No	0	8	8
287	R:R:L63	R:R:M309	2.83	No	No	0	7	5
288	R:R:I133	R:R:N134	2.83	No	No	0	6	8
289	R:R:Q209	R:R:T213	2.83	No	No	0	2	1
290	R:R:L243	R:R:M254	2.83	No	Yes	0	4	6
291	R:R:L313	R:R:M309	2.83	No	No	0	6	5
292	L:L:K49	L:L:L45	2.82	No	No	0	0	0
293	R:R:L198	R:R:L49	2.77	No	Yes	0	1	3
294	R:R:A54	R:R:F55	2.77	No	No	0	4	4
295	R:R:L62	R:R:L66	2.77	No	No	0	5	6
296	R:R:L78	R:R:L93	2.77	No	No	0	7	6
297	R:R:L79	R:R:L93	2.77	No	No	0	4	6
298	R:R:A222	R:R:F182	2.77	No	Yes	0	5	5
299	L:L:E25	L:L:K46	2.7	No	No	0	0	0
300	L:L:E69	L:L:K66	2.7	No	No	0	0	0
301	R:R:C179	R:R:Y136	2.69	No	No	0	8	6
302	L:L:L10	R:R:Q45	2.66	No	No	0	0	4
303	R:R:F51	R:R:S301	2.64	Yes	No	0	5	4
304	R:R:R81	R:R:S80	2.64	Yes	No	0	5	5
305	R:R:F51	R:R:V298	2.62	Yes	No	0	5	2
306	R:R:F51	R:R:V302	2.62	Yes	No	0	5	6
307	R:R:R82	R:R:T83	2.59	No	No	0	5	6
308	R:R:A98	R:R:W176	2.59	No	No	0	8	9
309	R:R:A192	R:R:W117	2.59	No	Yes	0	5	9
310	R:R:M331	R:R:R335	2.48	No	No	0	4	4
311	R:R:F119	R:R:L108	2.44	Yes	No	0	7	6
312	R:R:F187	R:R:L184	2.44	No	No	0	4	4
313	R:R:L256	R:R:R252	2.43	No	No	0	8	7
314	L:L:R8	R:R:D297	2.38	No	No	0	0	4
315	R:R:R328	R:R:R81	2.13	No	Yes	0	5	5
316	R:R:G223	R:R:P227	2.03	No	No	0	5	9
317	R:R:C290	R:R:G291	1.96	No	No	0	8	2
318	R:R:P41	R:R:P42	1.95	No	Yes	2	3	7
319	R:R:P41	R:R:P44	1.95	No	No	2	3	2
320	R:R:P42	R:R:P44	1.95	Yes	No	2	7	2
321	R:R:A139	R:R:G223	1.95	No	No	0	8	5
322	R:R:P164	R:R:P165	1.95	No	No	0	6	2
323	R:R:A214	R:R:G211	1.95	No	No	0	3	4
324	R:R:A114	R:R:P57	1.87	No	No	0	5	4
325	R:R:A143	R:R:P227	1.87	No	No	0	7	9
326	R:R:G211	R:R:V210	1.84	No	No	0	4	1
327	R:R:P208	R:R:V210	1.77	No	No	0	4	1
328	R:R:A58	R:R:S61	1.71	No	No	0	5	6
329	R:R:G305	R:R:L59	1.71	No	No	0	5	6
330	R:R:G67	R:R:L66	1.71	No	No	0	8	6
331	R:R:G138	R:R:L95	1.71	No	Yes	0	9	9
332	R:R:A192	R:R:S121	1.71	No	No	0	5	3
333	R:R:G177	R:R:L180	1.71	No	No	0	4	4
334	R:R:G284	R:R:L283	1.71	No	No	0	1	1
335	R:R:G307	R:R:L306	1.71	No	No	0	8	8
336	R:R:A114	R:R:V115	1.7	No	No	0	5	4
337	R:R:L56	R:R:P57	1.64	Yes	No	0	5	4
338	R:R:G247	R:R:Q248	1.64	No	No	0	3	3
339	L:L:N55	L:L:P56	1.63	Yes	No	0	0	0
340	R:R:V217	R:R:V221	1.6	No	No	0	4	5
341	R:R:V258	R:R:V262	1.6	No	No	0	5	5
342	R:R:A253	R:R:L242	1.58	No	No	0	7	8
343	R:R:A263	R:R:L317	1.58	No	No	0	6	8
344	R:R:A129	R:R:D186	1.54	No	Yes	0	5	4
345	R:R:K125	R:R:S121	1.53	No	No	0	7	3
346	L:L:K17	L:L:V19	1.52	No	No	0	0	0
347	R:R:G247	R:R:R246	1.5	No	No	0	3	4
348	R:R:L93	R:R:V97	1.49	No	No	0	6	6
349	R:R:L101	R:R:V97	1.49	No	No	0	5	6
350	R:R:L220	R:R:V221	1.49	No	No	0	4	5
351	L:L:N55	L:L:S58	1.49	Yes	No	0	0	0
352	R:R:L170	R:R:T169	1.47	No	No	0	2	4
353	R:R:G120	R:R:W117	1.41	No	Yes	0	8	9
354	L:L:K59	L:L:L63	1.41	No	No	0	0	0
355	R:R:H193	R:R:S191	1.39	No	No	0	3	4
356	R:R:L65	R:R:L66	1.38	No	No	0	5	6
357	R:R:A84	R:R:R81	1.38	No	Yes	0	7	5
358	R:R:L220	R:R:L276	1.38	No	No	0	4	5
359	R:R:L49	R:R:N50	1.37	Yes	No	0	3	4
360	L:L:M30	R:R:E196	1.35	No	No	0	0	1
361	L:L:E47	L:L:K46	1.35	No	No	0	0	0
362	R:R:R250	R:R:S245	1.32	No	No	0	6	4
363	R:R:R326	R:R:V323	1.31	No	No	0	8	5
364	R:R:R161	R:R:T157	1.29	No	No	0	4	5
365	R:R:H155	R:R:Q158	1.24	No	No	0	6	4
366	R:R:E327	R:R:R326	1.16	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P42	3.8525	4	2	7
2	R:R:L49	3.4475	4	0	3
3	R:R:F51	5.864	5	0	5
4	R:R:L56	6.442	5	4	5
5	R:R:Y60	7.8075	4	0	8
6	R:R:V74	4.215	4	5	9
7	R:R:R81	3.8025	4	0	5
8	R:R:D89	6.1125	4	6	8
9	R:R:F91	4.77667	6	0	7
10	R:R:L95	4.184	5	1	9
11	R:R:D99	5.895	4	1	9
12	R:R:W109	8.1925	4	1	5
13	R:R:W117	6.20333	6	1	9
14	R:R:F119	6.608	5	0	7
15	R:R:F131	7.584	5	1	5
16	R:R:D148	6.198	5	0	8
17	R:R:F182	6.62	4	0	5
18	R:R:D186	7.588	5	1	4
19	R:R:R197	7.695	6	3	4
20	R:R:Y205	7.23	7	1	3
21	R:R:F207	7.56	4	1	4
22	R:R:R216	6.6925	4	1	3
23	R:R:Q219	7.095	4	1	5
24	R:R:F224	7.365	4	0	8
25	R:R:Y235	6.58333	6	1	8
26	R:R:M254	3.7575	4	7	6
27	R:R:F264	6.2025	4	1	9
28	R:R:W268	6.48333	6	1	9
29	R:R:Y271	6.798	5	1	6
30	R:R:H272	7.4025	4	1	8
31	R:R:H310	10.24	4	1	9
32	R:R:Y318	5.104	5	1	9
33	R:R:F325	7.314	5	5	8
34	L:L:F1	10.392	5	1	0
35	L:L:M3	6.446	5	1	0
36	L:L:F4	5.90333	6	1	0
37	L:L:R6	10.232	5	1	0
38	L:L:I29	6.435	4	0	0
39	L:L:E40	9.19	4	3	0
40	L:L:I42	4.375	4	0	0
41	L:L:T44	6.9375	4	2	0
42	L:L:N55	3.8	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I42	R:R:P42	14.0059	6.77	Yes	Yes	0	0	7
2	L:L:R8	R:R:E293	17.6626	12.79	No	No	0	0	1
3	L:L:R8	R:R:D297	19.2206	2.38	No	No	0	0	4
4	R:R:D297	R:R:S48	20.7706	7.36	No	No	0	4	4
5	R:R:Q45	R:R:S48	35.8299	2.89	No	No	0	4	4
6	L:L:L10	R:R:Q45	37.2917	2.66	No	No	0	0	4
7	L:L:C11	L:L:E40	36.8472	4.56	No	Yes	0	0	0
8	L:L:C11	L:L:C53	35.4454	7.28	No	No	0	0	0
9	L:L:C53	L:L:I42	34.0035	3.27	No	Yes	0	0	0
10	R:R:L56	R:R:S301	11.1463	6.01	Yes	No	0	5	4
11	R:R:L56	R:R:Y60	23.2137	10.55	Yes	Yes	0	5	8
12	R:R:Y308	R:R:Y60	42.2781	4.96	No	Yes	0	6	8
13	R:R:F131	R:R:Y308	44.537	7.22	Yes	No	0	5	6
14	L:L:F1	R:R:F131	57.5937	12.86	Yes	Yes	1	0	5
15	L:L:F1	L:L:F4	100	3.22	Yes	Yes	1	0	0
16	L:L:F4	R:R:R212	91.393	4.28	Yes	No	1	0	4
17	L:L:R6	R:R:R212	88.9218	17.06	Yes	No	1	0	4
18	L:L:G7	L:L:R6	82.3574	3	No	Yes	0	0	0
19	L:L:G7	R:R:R197	81.1919	3	No	Yes	0	0	4
20	L:L:E40	R:R:R197	35.3773	17.45	Yes	Yes	3	0	4
21	R:R:L49	R:R:S48	14.5226	6.01	Yes	No	0	3	4
22	R:R:C124	R:R:W117	18.1112	3.92	No	Yes	1	9	9
23	R:R:C124	R:R:L190	21.0069	3.17	No	No	1	9	5
24	R:R:L190	R:R:Y205	21.5476	8.21	No	Yes	1	5	3
25	L:L:F4	R:R:Y205	30.5631	3.09	Yes	Yes	1	0	3
26	R:R:G67	R:R:V103	13.8938	5.52	No	No	0	8	6
27	R:R:L68	R:R:V103	15.2395	2.98	No	No	0	6	6
28	R:R:F64	R:R:L68	16.5772	8.53	No	No	0	7	6
29	R:R:F64	R:R:P107	17.9069	11.56	No	No	0	7	9
30	R:R:L106	R:R:P107	19.2286	3.28	No	No	0	8	9
31	R:R:L106	R:R:Y60	20.5423	11.72	No	Yes	0	8	8
32	R:R:C311	R:R:D99	30.6312	4.67	No	Yes	0	8	9
33	R:R:C311	R:R:L102	30.9636	3.17	No	No	0	8	6
34	R:R:F131	R:R:L102	52.9678	8.53	Yes	No	0	5	6
35	R:R:D99	R:R:N71	25.0801	6.73	Yes	No	0	9	9
36	R:R:N71	R:R:P315	22.9414	9.77	No	No	0	9	9
37	R:R:P315	R:R:V74	21.868	3.53	No	Yes	0	9	9
38	R:R:F325	R:R:V74	17.3863	6.55	Yes	Yes	5	8	9
39	R:R:F325	R:R:L78	13.245	6.09	Yes	No	0	8	7
40	R:R:L78	R:R:L93	16.9096	2.77	No	No	0	7	6
41	R:R:L93	R:R:V97	18.8802	1.49	No	No	0	6	6
42	R:R:L101	R:R:V97	20.2099	1.49	No	No	0	5	6
43	R:R:L101	R:R:N134	21.5436	8.24	No	No	0	5	8
44	R:R:L102	R:R:N134	28.152	8.24	No	No	0	6	8
45	R:R:F325	R:R:V77	15.5038	9.18	Yes	No	0	8	7
46	R:R:M329	R:R:V77	13.5934	4.56	No	No	0	6	7
47	R:R:D89	R:R:L78	13.1248	5.43	Yes	No	0	8	7
48	R:R:D148	R:R:F91	19.8574	4.78	Yes	Yes	0	8	7
49	R:R:F91	R:R:I145	38.9579	3.77	Yes	No	0	7	9
50	R:R:I145	R:R:R149	28.0519	3.76	No	No	1	9	9
51	R:R:R149	R:R:Y235	36.6309	8.23	No	Yes	1	9	8
52	R:R:M231	R:R:Y235	59.8046	3.59	No	Yes	1	8	8
53	R:R:F264	R:R:M231	82.7139	6.22	Yes	No	1	9	8
54	R:R:F264	R:R:W268	78.3242	7.02	Yes	Yes	1	9	9
55	R:R:F135	R:R:W268	46.1951	6.01	No	Yes	0	7	9
56	L:L:F1	R:R:F135	48.8025	11.79	Yes	No	0	0	7
57	R:R:W268	R:R:Y271	47.4007	5.79	Yes	Yes	1	9	6
58	L:L:F1	R:R:Y271	57.8501	12.38	Yes	Yes	1	0	6
59	R:R:D99	R:R:L95	22.7772	6.79	Yes	Yes	1	9	9
60	R:R:H310	R:R:N314	18.3595	15.31	Yes	No	1	9	9
61	R:R:H310	R:R:W268	14.3143	7.41	Yes	Yes	1	9	9
62	R:R:L142	R:R:L95	23.8826	4.15	No	Yes	0	8	9
63	L:L:M3	R:R:Y205	15.7201	5.99	Yes	Yes	1	0	3
64	R:R:A129	R:R:D186	10.6336	1.54	No	Yes	0	5	4
65	R:R:Q219	R:R:Y136	10.8579	4.51	Yes	No	0	5	6
66	R:R:L142	R:R:Y318	22.4728	5.86	No	Yes	0	8	9
67	R:R:M231	R:R:S146	21.3834	6.13	No	No	1	8	9
68	R:R:C234	R:R:S146	21.892	3.44	No	No	0	7	9
69	R:R:D148	R:R:R167	12.7643	4.76	Yes	No	0	8	4
70	R:R:C234	R:R:Y150	19.9415	8.06	No	No	0	7	8
71	R:R:V154	R:R:Y150	14.042	11.36	No	No	0	7	8
72	R:R:H155	R:R:V154	10.0689	4.15	No	No	0	6	7
73	R:R:F207	R:R:Y205	12.524	11.35	Yes	Yes	1	4	3
74	R:R:F207	R:R:G211	12.5721	4.52	Yes	No	0	4	4
75	R:R:I238	R:R:Y235	21.4234	3.63	No	Yes	0	8	8
76	R:R:V257	R:R:Y235	10.8098	8.83	No	Yes	0	7	8
77	R:R:I238	R:R:L242	17.202	2.85	No	No	0	8	8
78	R:R:L242	R:R:M254	12.9486	4.24	No	Yes	0	8	6
79	R:R:M329	R:R:W330	11.6749	6.98	No	No	0	6	2
80	L:L:E25	L:L:T44	11.2103	5.64	No	Yes	0	0	0
81	L:L:I42	L:L:K26	17.1219	4.36	Yes	No	0	0	0
82	L:L:K26	L:L:T44	14.0179	12.01	No	Yes	2	0	0
83	L:L:L10	R:R:R197	35.8419	3.64	No	Yes	3	0	4
84	R:R:I145	R:R:Y318	12.5721	6.04	No	Yes	1	9	9
85	L:L:M3	R:R:F131	20.4662	4.98	Yes	Yes	1	0	5
86	L:L:F1	R:R:Q219	12.0875	11.71	Yes	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:P41	R:R:S40	5.34	2	No	No	3	4	2	1
L:L:R52	R:R:S40	9.22	0	No	No	0	4	0	1
L:L:I42	R:R:P42	6.77	0	Yes	Yes	0	7	0	1
L:L:Q51	R:R:P42	4.74	2	No	Yes	0	7	0	1
R:R:C290	R:R:C43	5.46	0	No	No	8	9	2	1
L:L:I12	R:R:C43	3.27	0	No	No	0	9	0	1
R:R:D297	R:R:S48	7.36	0	No	No	4	4	1	2
R:R:D52	R:R:L56	10.86	4	No	Yes	5	5	1	2
R:R:A113	R:R:D52	4.63	4	No	No	5	5	2	1
L:L:K5	R:R:D52	4.15	0	No	No	0	5	0	1
R:R:A113	R:R:L56	3.15	4	No	Yes	5	5	2	2
R:R:F131	R:R:L102	8.53	1	Yes	No	5	6	1	2
R:R:T105	R:R:W109	6.06	0	No	Yes	7	5	2	1
R:R:A127	R:R:W109	3.89	0	No	Yes	5	5	2	1
L:L:P2	R:R:W109	13.51	1	No	Yes	0	5	0	1
L:L:M3	R:R:W109	9.31	1	Yes	Yes	0	5	0	1
R:R:D112	R:R:H202	10.08	0	No	No	5	3	2	1
R:R:D186	R:R:G128	5.03	1	Yes	No	4	6	2	1
L:L:M3	R:R:G128	5.24	1	Yes	No	0	6	0	1
R:R:F131	R:R:Y308	7.22	1	Yes	No	5	6	1	2
L:L:F1	R:R:F131	12.86	1	Yes	Yes	0	5	0	1
L:L:P2	R:R:F131	4.33	1	No	Yes	0	5	0	1
L:L:M3	R:R:F131	4.98	1	Yes	Yes	0	5	0	1
R:R:D186	R:R:N132	8.08	1	Yes	No	4	4	2	2
R:R:N132	R:R:Y205	3.49	1	No	Yes	4	3	2	1
R:R:N132	R:R:Q219	3.96	1	No	Yes	4	5	2	1
R:R:F135	R:R:G223	3.01	0	No	No	7	5	1	2
R:R:F135	R:R:W268	6.01	0	No	Yes	7	9	1	2
L:L:F1	R:R:F135	11.79	1	Yes	No	0	7	0	1
R:R:Q219	R:R:Y136	4.51	1	Yes	No	5	6	1	2
R:R:D186	R:R:L190	9.5	1	Yes	No	4	5	2	2
R:R:D186	R:R:Y205	13.79	1	Yes	Yes	4	3	2	1
R:R:L190	R:R:Y205	8.21	1	No	Yes	5	3	2	1
R:R:E196	R:R:H194	9.85	0	No	No	1	2	1	2
L:L:G7	R:R:R197	3	0	No	Yes	0	4	0	1
L:L:L10	R:R:R197	3.64	3	No	Yes	0	4	0	1
L:L:M30	R:R:R197	11.17	3	No	Yes	0	4	0	1
L:L:S33	R:R:R197	3.95	0	No	Yes	0	4	0	1
L:L:C36	R:R:R197	6.96	0	No	Yes	0	4	0	1
L:L:E40	R:R:R197	17.45	3	Yes	Yes	0	4	0	1
L:L:K5	R:R:H202	5.24	0	No	No	0	3	0	1
R:R:F207	R:R:Y205	11.35	1	Yes	Yes	4	3	2	1
R:R:L215	R:R:Y205	4.69	1	No	Yes	5	3	1	1
L:L:M3	R:R:Y205	5.99	1	Yes	Yes	0	3	0	1
L:L:F4	R:R:Y205	3.09	1	Yes	Yes	0	3	0	1
R:R:F207	R:R:L215	3.65	1	Yes	No	4	5	2	1
L:L:N34	R:R:P208	3.26	0	No	No	0	4	0	1
R:R:D282	R:R:Q209	6.53	1	No	No	2	2	1	1
L:L:R6	R:R:Q209	5.84	1	Yes	No	0	2	0	1
L:L:F4	R:R:R212	4.28	1	Yes	No	0	4	0	1
L:L:R6	R:R:R212	17.06	1	Yes	No	0	4	0	1
L:L:N35	R:R:R212	10.85	1	No	No	0	4	0	1
L:L:F4	R:R:L215	4.87	1	Yes	No	0	5	0	1
R:R:R216	R:R:V275	3.92	1	Yes	No	3	5	1	2
R:R:D278	R:R:R216	3.57	0	No	Yes	5	3	2	1
R:R:I279	R:R:R216	7.52	1	No	Yes	5	3	2	1
L:L:F4	R:R:R216	11.76	1	Yes	Yes	0	3	0	1
L:L:F1	R:R:Q219	11.71	1	Yes	Yes	0	5	0	1
L:L:F4	R:R:Q219	8.2	1	Yes	Yes	0	5	0	1
R:R:W268	R:R:Y271	5.79	1	Yes	Yes	9	6	2	1
R:R:H272	R:R:W268	4.23	1	Yes	Yes	8	9	2	2
R:R:H272	R:R:Y271	3.27	1	Yes	Yes	8	6	2	1
R:R:V275	R:R:Y271	6.31	1	No	Yes	5	6	2	1
R:R:T303	R:R:Y271	6.24	0	No	Yes	7	6	2	1
L:L:F1	R:R:Y271	12.38	1	Yes	Yes	0	6	0	1
R:R:I279	R:R:V275	3.07	1	No	No	5	5	2	2
R:R:E293	R:R:M281	5.41	0	No	No	1	3	1	2
R:R:D282	R:R:L283	5.43	1	No	No	2	1	1	2
L:L:R6	R:R:D282	3.57	1	Yes	No	0	2	0	1
R:R:E293	R:R:R288	10.47	0	No	No	1	4	1	1
L:L:I12	R:R:R288	6.26	0	No	No	0	4	0	1
L:L:R8	R:R:E293	12.79	0	No	No	0	1	0	1
R:R:A200	R:R:H202	2.93	0	No	No	1	3	2	1
R:R:Q45	R:R:S48	2.89	0	No	No	4	4	1	2
R:R:Q209	R:R:T213	2.83	1	No	No	2	1	1	2
L:L:L10	R:R:Q45	2.66	3	No	No	0	4	0	1
L:L:R8	R:R:D297	2.38	0	No	No	0	4	0	1
R:R:P41	R:R:P42	1.95	2	No	Yes	3	7	2	1
R:R:P41	R:R:P44	1.95	2	No	No	3	2	2	2
R:R:P42	R:R:P44	1.95	2	Yes	No	7	2	1	2
R:R:P208	R:R:V210	1.77	0	No	No	4	1	1	2
L:L:M30	R:R:E196	1.35	3	No	No	0	1	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HNK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	335
Number of Links	366
Number of Hubs	42
Number of Links mediated by Hubs	170
Number of Communities	8
Number of Nodes involved in Communities	65
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	63352
Length Of Smallest Path	3
Average Path Length	14.0916
Length of Longest Path	33
Minimum Path Strength	1.235
Average Path Strength	6.23688
Maximum Path Strength	13.765
Minimum Path Correlation	0.7
Average Path Correlation	0.953255
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	66.0372
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6067
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • oxidoreductase activity • monooxygenase activity • Oplophorus-luciferin 2-monooxygenase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen • luciferin monooxygenase activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell adhesion • regulation of cell adhesion • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • calcium-mediated signaling • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • electron transport chain • generation of precursor metabolites and energy • bioluminescence • cell surface • external side of plasma membrane • periplasmic space • molecular function activator activity • signaling receptor binding • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • CXCR chemokine receptor binding • CXCR3 chemokine receptor binding • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8HNK_nogp_Chain_R S P P C P Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	10.1038/s41594-023-01175-5
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	To be published
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	To be published
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	To be published
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go1/β1/γ2	3.07	2025-02-26	To be published
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	To be published
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go1/β1/γ2	3.03	2025-02-26	To be published
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	To be published
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go1/β1/γ2	3.3	2025-02-26	To be published
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	To be published

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