Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:P42 3.8525427
2R:R:L49 3.4475403
3R:R:F51 5.864505
4R:R:L56 6.442545
5R:R:Y60 7.8075408
6R:R:V74 4.215459
7R:R:R81 3.8025405
8R:R:D89 6.1125468
9R:R:F91 4.77667607
10R:R:L95 4.184519
11R:R:D99 5.895419
12R:R:W109 8.1925415
13R:R:W117 6.20333619
14R:R:F119 6.608507
15R:R:F131 7.584515
16R:R:D148 6.198508
17R:R:F182 6.62405
18R:R:D186 7.588514
19R:R:R197 7.695634
20R:R:Y205 7.23713
21R:R:F207 7.56414
22R:R:R216 6.6925413
23R:R:Q219 7.095415
24R:R:F224 7.365408
25R:R:Y235 6.58333618
26R:R:M254 3.7575476
27R:R:F264 6.2025419
28R:R:W268 6.48333619
29R:R:Y271 6.798516
30R:R:H272 7.4025418
31R:R:H310 10.24419
32R:R:Y318 5.104519
33R:R:F325 7.314558
34L:L:F22 10.392514
35L:L:M24 6.446514
36L:L:F25 5.90333611
37L:L:R27 10.232513
38L:L:I50 6.435406
39L:L:E61 9.19439
40L:L:I63 4.375409
41L:L:T65 6.9375429
42L:L:N76 3.8408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:I63 R:R:P42 14.00596.77YesYes097
2L:L:R29 R:R:E293 17.662612.79NoNo091
3L:L:R29 R:R:D297 19.22062.38NoNo094
4R:R:D297 R:R:S48 20.77067.36NoNo044
5R:R:Q45 R:R:S48 35.82992.89NoNo044
6L:L:L31 R:R:Q45 37.29172.66NoNo054
7L:L:C32 L:L:E61 36.84724.56NoYes099
8L:L:C32 L:L:C74 35.44547.28NoNo099
9L:L:C74 L:L:I63 34.00353.27NoYes099
10R:R:L56 R:R:S301 11.14636.01YesNo054
11R:R:L56 R:R:Y60 23.213710.55YesYes058
12R:R:Y308 R:R:Y60 42.27814.96NoYes068
13R:R:F131 R:R:Y308 44.5377.22YesNo056
14L:L:F22 R:R:F131 57.593712.86YesYes145
15L:L:F22 L:L:F25 1003.22YesYes141
16L:L:F25 R:R:R212 91.3934.28YesNo114
17L:L:R27 R:R:R212 88.921817.06YesNo134
18L:L:G28 L:L:R27 82.35743NoYes043
19L:L:G28 R:R:R197 81.19193NoYes044
20L:L:E61 R:R:R197 35.377317.45YesYes394
21R:R:L49 R:R:S48 14.52266.01YesNo034
22R:R:C124 R:R:W117 18.11123.92NoYes199
23R:R:C124 R:R:L190 21.00693.17NoNo195
24R:R:L190 R:R:Y205 21.54768.21NoYes153
25L:L:F25 R:R:Y205 30.56313.09YesYes113
26R:R:G67 R:R:V103 13.89385.52NoNo086
27R:R:L68 R:R:V103 15.23952.98NoNo066
28R:R:F64 R:R:L68 16.57728.53NoNo076
29R:R:F64 R:R:P107 17.906911.56NoNo079
30R:R:L106 R:R:P107 19.22863.28NoNo089
31R:R:L106 R:R:Y60 20.542311.72NoYes088
32R:R:C311 R:R:D99 30.63124.67NoYes089
33R:R:C311 R:R:L102 30.96363.17NoNo086
34R:R:F131 R:R:L102 52.96788.53YesNo056
35R:R:D99 R:R:N71 25.08016.73YesNo099
36R:R:N71 R:R:P315 22.94149.77NoNo099
37R:R:P315 R:R:V74 21.8683.53NoYes099
38R:R:F325 R:R:V74 17.38636.55YesYes589
39R:R:F325 R:R:L78 13.2456.09YesNo087
40R:R:L78 R:R:L93 16.90962.77NoNo076
41R:R:L93 R:R:V97 18.88021.49NoNo066
42R:R:L101 R:R:V97 20.20991.49NoNo056
43R:R:L101 R:R:N134 21.54368.24NoNo058
44R:R:L102 R:R:N134 28.1528.24NoNo068
45R:R:F325 R:R:V77 15.50389.18YesNo087
46R:R:M329 R:R:V77 13.59344.56NoNo067
47R:R:D89 R:R:L78 13.12485.43YesNo087
48R:R:D148 R:R:F91 19.85744.78YesYes087
49R:R:F91 R:R:I145 38.95793.77YesNo079
50R:R:I145 R:R:R149 28.05193.76NoNo199
51R:R:R149 R:R:Y235 36.63098.23NoYes198
52R:R:M231 R:R:Y235 59.80463.59NoYes188
53R:R:F264 R:R:M231 82.71396.22YesNo198
54R:R:F264 R:R:W268 78.32427.02YesYes199
55R:R:F135 R:R:W268 46.19516.01NoYes079
56L:L:F22 R:R:F135 48.802511.79YesNo047
57R:R:W268 R:R:Y271 47.40075.79YesYes196
58L:L:F22 R:R:Y271 57.850112.38YesYes146
59R:R:D99 R:R:L95 22.77726.79YesYes199
60R:R:H310 R:R:N314 18.359515.31YesNo199
61R:R:H310 R:R:W268 14.31437.41YesYes199
62R:R:L142 R:R:L95 23.88264.15NoYes089
63L:L:M24 R:R:Y205 15.72015.99YesYes143
64R:R:A129 R:R:D186 10.63361.54NoYes054
65R:R:Q219 R:R:Y136 10.85794.51YesNo056
66R:R:L142 R:R:Y318 22.47285.86NoYes089
67R:R:M231 R:R:S146 21.38346.13NoNo189
68R:R:C234 R:R:S146 21.8923.44NoNo079
69R:R:D148 R:R:R167 12.76434.76YesNo084
70R:R:C234 R:R:Y150 19.94158.06NoNo078
71R:R:V154 R:R:Y150 14.04211.36NoNo078
72R:R:H155 R:R:V154 10.06894.15NoNo067
73R:R:F207 R:R:Y205 12.52411.35YesYes143
74R:R:F207 R:R:G211 12.57214.52YesNo044
75R:R:I238 R:R:Y235 21.42343.63NoYes088
76R:R:V257 R:R:Y235 10.80988.83NoYes078
77R:R:I238 R:R:L242 17.2022.85NoNo088
78R:R:L242 R:R:M254 12.94864.24NoYes086
79R:R:M329 R:R:W330 11.67496.98NoNo062
80L:L:E46 L:L:T65 11.21035.64NoYes059
81L:L:I63 L:L:K47 17.12194.36YesNo097
82L:L:K47 L:L:T65 14.017912.01NoYes279
83L:L:L31 R:R:R197 35.84193.64NoYes354
84R:R:I145 R:R:Y318 12.57216.04NoYes199
85L:L:M24 R:R:F131 20.46624.98YesYes145
86L:L:F22 R:R:Q219 12.087511.71YesYes145
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:P41 R:R:S40 5.34 2 No No 3 4 2 1
L:L:R73 R:R:S40 9.22 0 No No 5 4 0 1
L:L:I63 R:R:P42 6.77 0 Yes Yes 9 7 0 1
L:L:Q72 R:R:P42 4.74 2 No Yes 5 7 0 1
R:R:C290 R:R:C43 5.46 0 No No 8 9 2 1
L:L:I33 R:R:C43 3.27 0 No No 4 9 0 1
R:R:D297 R:R:S48 7.36 0 No No 4 4 1 2
R:R:D52 R:R:L56 10.86 4 No Yes 5 5 1 2
R:R:A113 R:R:D52 4.63 4 No No 5 5 2 1
L:L:K26 R:R:D52 4.15 0 No No 4 5 0 1
R:R:A113 R:R:L56 3.15 4 No Yes 5 5 2 2
R:R:F131 R:R:L102 8.53 1 Yes No 5 6 1 2
R:R:T105 R:R:W109 6.06 0 No Yes 7 5 2 1
R:R:A127 R:R:W109 3.89 0 No Yes 5 5 2 1
L:L:P23 R:R:W109 13.51 1 No Yes 3 5 0 1
L:L:M24 R:R:W109 9.31 1 Yes Yes 4 5 0 1
R:R:D112 R:R:H202 10.08 0 No No 5 3 2 1
R:R:D186 R:R:G128 5.03 1 Yes No 4 6 2 1
L:L:M24 R:R:G128 5.24 1 Yes No 4 6 0 1
R:R:F131 R:R:Y308 7.22 1 Yes No 5 6 1 2
L:L:F22 R:R:F131 12.86 1 Yes Yes 4 5 0 1
L:L:P23 R:R:F131 4.33 1 No Yes 3 5 0 1
L:L:M24 R:R:F131 4.98 1 Yes Yes 4 5 0 1
R:R:D186 R:R:N132 8.08 1 Yes No 4 4 2 2
R:R:N132 R:R:Y205 3.49 1 No Yes 4 3 2 1
R:R:N132 R:R:Q219 3.96 1 No Yes 4 5 2 1
R:R:F135 R:R:G223 3.01 0 No No 7 5 1 2
R:R:F135 R:R:W268 6.01 0 No Yes 7 9 1 2
L:L:F22 R:R:F135 11.79 1 Yes No 4 7 0 1
R:R:Q219 R:R:Y136 4.51 1 Yes No 5 6 1 2
R:R:D186 R:R:L190 9.5 1 Yes No 4 5 2 2
R:R:D186 R:R:Y205 13.79 1 Yes Yes 4 3 2 1
R:R:L190 R:R:Y205 8.21 1 No Yes 5 3 2 1
R:R:E196 R:R:H194 9.85 0 No No 1 2 1 2
L:L:G28 R:R:R197 3 0 No Yes 4 4 0 1
L:L:L31 R:R:R197 3.64 3 No Yes 5 4 0 1
L:L:M51 R:R:R197 11.17 3 No Yes 3 4 0 1
L:L:S54 R:R:R197 3.95 0 No Yes 9 4 0 1
L:L:C57 R:R:R197 6.96 0 No Yes 9 4 0 1
L:L:E61 R:R:R197 17.45 3 Yes Yes 9 4 0 1
L:L:K26 R:R:H202 5.24 0 No No 4 3 0 1
R:R:F207 R:R:Y205 11.35 1 Yes Yes 4 3 2 1
R:R:L215 R:R:Y205 4.69 1 No Yes 5 3 1 1
L:L:M24 R:R:Y205 5.99 1 Yes Yes 4 3 0 1
L:L:F25 R:R:Y205 3.09 1 Yes Yes 1 3 0 1
R:R:F207 R:R:L215 3.65 1 Yes No 4 5 2 1
L:L:N55 R:R:P208 3.26 0 No No 4 4 0 1
R:R:D282 R:R:Q209 6.53 1 No No 2 2 1 1
L:L:R27 R:R:Q209 5.84 1 Yes No 3 2 0 1
L:L:F25 R:R:R212 4.28 1 Yes No 1 4 0 1
L:L:R27 R:R:R212 17.06 1 Yes No 3 4 0 1
L:L:N56 R:R:R212 10.85 1 No No 7 4 0 1
L:L:F25 R:R:L215 4.87 1 Yes No 1 5 0 1
R:R:R216 R:R:V275 3.92 1 Yes No 3 5 1 2
R:R:D278 R:R:R216 3.57 0 No Yes 5 3 2 1
R:R:I279 R:R:R216 7.52 1 No Yes 5 3 2 1
L:L:F25 R:R:R216 11.76 1 Yes Yes 1 3 0 1
L:L:F22 R:R:Q219 11.71 1 Yes Yes 4 5 0 1
L:L:F25 R:R:Q219 8.2 1 Yes Yes 1 5 0 1
R:R:W268 R:R:Y271 5.79 1 Yes Yes 9 6 2 1
R:R:H272 R:R:W268 4.23 1 Yes Yes 8 9 2 2
R:R:H272 R:R:Y271 3.27 1 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 6.31 1 No Yes 5 6 2 1
R:R:T303 R:R:Y271 6.24 0 No Yes 7 6 2 1
L:L:F22 R:R:Y271 12.38 1 Yes Yes 4 6 0 1
R:R:I279 R:R:V275 3.07 1 No No 5 5 2 2
R:R:E293 R:R:M281 5.41 0 No No 1 3 1 2
R:R:D282 R:R:L283 5.43 1 No No 2 1 1 2
L:L:R27 R:R:D282 3.57 1 Yes No 3 2 0 1
R:R:E293 R:R:R288 10.47 0 No No 1 4 1 1
L:L:I33 R:R:R288 6.26 0 No No 4 4 0 1
L:L:R29 R:R:E293 12.79 0 No No 9 1 0 1
R:R:A200 R:R:H202 2.93 0 No No 1 3 2 1
R:R:Q45 R:R:S48 2.89 0 No No 4 4 1 2
R:R:Q209 R:R:T213 2.83 1 No No 2 1 1 2
L:L:L31 R:R:Q45 2.66 3 No No 5 4 0 1
L:L:R29 R:R:D297 2.38 0 No No 9 4 0 1
R:R:P41 R:R:P42 1.95 2 No Yes 3 7 2 1
R:R:P41 R:R:P44 1.95 2 No No 3 2 2 2
R:R:P42 R:R:P44 1.95 2 Yes No 7 2 1 2
R:R:P208 R:R:V210 1.77 0 No No 4 1 1 2
L:L:M51 R:R:E196 1.35 3 No No 3 1 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8HNK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3
Number of Linked Nodes 335
Number of Links 366
Number of Hubs 42
Number of Links mediated by Hubs 170
Number of Communities 8
Number of Nodes involved in Communities 65
Number of Links involved in Communities 86
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 63352
Length Of Smallest Path 3
Average Path Length 14.0916
Length of Longest Path 33
Minimum Path Strength 1.235
Average Path Strength 6.23688
Maximum Path Strength 13.765
Minimum Path Correlation 0.7
Average Path Correlation 0.953254
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5
Average % Of Corr. Nodes 66.0302
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.6067
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP49682
Sequence
>8HNK_nogp_Chain_R
SPPCPQDFS LNFDRAFLP ALYSLLFLL GLLGNGAVA AVLLSRRTA 
LSSTDTFLL HLAVADTLL VLTLPLWAV DAAVQWVFG SGLCKVAGA 
LFNINFYAG ALLLACISF DRYLNIVHA TQLYRRGPP ARVTLTCLA 
VWGLCLLFA LPDFIFLSA HHDERLNAT HCQYNFPQV GRTALRVLQ 
LVAGFLLPL LVMAYCYAH ILAVLLVSR GQRRLRAMR LVVVVVVAF 
ALCWTPYHL VVLVDILMD LGALARNCG RESRVDVAK SVTSGLGYM 
HCCLNPLLY AFVGVKFRE RMWMLLLRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainL
ProteinCXCL11
UniProtO14625
Sequence
>8HNK_nogp_Chain_L
FPMFKRGRC LCIGPGVKA VKVADIEKA SIMYPSNNC DKIEVIITL 
KENKGQRCL NPKSKQARL IIKKVERKN F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HNKAProteinChemokineCXCR3Homo sapiensCXCL11-Gi1/β1/γ23.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNK (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL11-3.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNLAProteinChemokineCXCR3Homo sapiensPS372424-Gi1/β1/γ22.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNL (No Gprot) AProteinChemokineCXCR3Homo sapiensPS372424-2.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNMAProteinChemokineCXCR3Homo sapiensVUF11222-Gi1/β1/γ22.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNM (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11222-2.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNNAProteinChemokineCXCR3Homo sapiens-SCH546738-3.62023-11-29doi.org/10.1038/s41594-023-01175-5
8K2WAProteinChemokineCXCR3Homo sapiensAMG487--32023-11-29doi.org/10.1038/s41594-023-01175-5
8K2XAProteinChemokineCXCR3Homo sapiensCXCL10-Gi1/β1/γ23.22023-11-29doi.org/10.1038/s41594-023-01175-5
8K2X (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL10-3.22023-11-29doi.org/10.1038/s41594-023-01175-5
8XXYAProteinChemokineCXCR3Homo sapiens---3.682025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZAProteinChemokineCXCR3Homo sapiens--Go/β1/γ23.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZ (No Gprot) AProteinChemokineCXCR3Homo sapiens--3.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XYIAProteinChemokineCXCR3Homo sapiensVUF10661--3.162025-02-26doi.org/10.1038/s41467-025-58264-w
8XYKAProteinChemokineCXCR3Homo sapiensVUF10661-Go/β1/γ23.032025-02-26doi.org/10.1038/s41467-025-58264-w
8XYK (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF10661-3.032025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0HAProteinChemokineCXCR3Homo sapiensVUF11418--3.532025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0NAProteinChemokineCXCR3Homo sapiensVUF11418-Go/β1/γ23.072025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0N (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11418-3.072025-02-26doi.org/10.1038/s41467-025-58264-w




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Download 8HNK_nogp.zip



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