Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 4.7825134
2A:A:L36 3.94754137
3A:A:L37 5.348519
4A:A:I49 4.2407
5A:A:H196 3.9525413
6A:A:F197 7.175407
7A:A:R198 9.375416
8A:A:F200 9.656516
9A:A:V202 4.335419
10A:A:K211 8.37469
11A:A:W212 5.728519
12A:A:H214 4.8325498
13A:A:F216 5.85429719
14A:A:T220 3.68254137
15A:A:I222 3.8875417
16A:A:I223 3.9675407
17A:A:F224 4.955409
18A:A:Y231 4.7475408
19A:A:R243 2.868509
20A:A:F251 6.278519
21A:A:F259 5.97404
22A:A:F268 4.1965189
23A:A:L269 4.36408
24A:A:F275 6.195408
25A:A:I279 3.3425407
26A:A:F288 4.2175408
27A:A:F308 5.352508
28A:A:Y320 6.5985228
29A:A:T324 5.65754189
30A:A:C325 3.538507
31A:A:F336 4.235128
32A:A:I343 3.745408
33A:A:L353 4.914236
34A:A:Y354 10.97254215
35B:B:Q13 7.47401
36B:B:L14 5.1325408
37B:B:L30 3.5925405
38B:B:I37 4.284502
39B:B:V40 4.9954143
40B:B:H54 8.071676159
41B:B:Y59 7.8475498
42B:B:W63 6.696537
43B:B:V71 4.665408
44B:B:D76 5.0365159
45B:B:K78 3.97408
46B:B:L79 4.4154107
47B:B:W82 8.382509
48B:B:K89 5.406509
49B:B:H91 5.49405
50B:B:I93 5.43254107
51B:B:L95 4.844108
52B:B:W99 9.172519
53B:B:Y105 5.06506
54B:B:N110 6.8654164
55B:B:Y111 5.24254164
56B:B:C121 3.34478
57B:B:I123 4.0975406
58B:B:Y124 5.351676106
59B:B:V133 5.40754104
60B:B:H142 5.82679
61B:B:Y145 4.798568
62B:B:L146 4.126577
63B:B:F151 4.49667609
64B:B:L152 3.64503
65B:B:T159 5.745479
66B:B:W169 6.76667678
67B:B:F180 5.2425447
68B:B:H183 7.81649
69B:B:D186 3.8925469
70B:B:V187 5.0875449
71B:B:F199 6.94449
72B:B:V200 6.5325426
73B:B:S201 4.6075449
74B:B:C204 4.385467
75B:B:D205 4.884549
76B:B:K209 9.4925446
77B:B:W211 7.17667648
78B:B:C218 4.7725445
79B:B:F222 7.5075428
80B:B:H225 8.69509
81B:B:D228 7.758569
82B:B:I232 4.6425428
83B:B:F235 6.148336116
84B:B:P236 6.0154117
85B:B:N237 7.77254115
86B:B:F241 7.29526
87B:B:T249 4.3625426
88B:B:R251 10.402528
89B:B:F253 7.16526
90B:B:D258 9.22427
91B:B:Q259 4.12506
92B:B:M262 4.8375404
93B:B:T263 5.905421
94B:B:Y264 6.512505
95B:B:R283 6.385149
96B:B:L285 3.56406
97B:B:Y289 8.464177
98B:B:C294 3.8975485
99B:B:N295 8.334176
100B:B:W297 7.96254178
101B:B:L308 5.5825407
102B:B:H311 9.994589
103B:B:T329 5.7975408
104B:B:W332 11.6129799
105B:B:K337 6.71486
106B:B:I338 5.5425435
107B:B:W339 8.2625489
108B:B:N340 6.455439
109G:G:Y40 7.44754116
110G:G:D48 4.956509
111G:G:L51 3.5585146
112G:G:N59 5.895439
113G:G:P60 7.16439
114G:G:F61 5.29125838
115R:R:V74 4.2154259
116R:R:R81 8.22754245
117R:R:F91 6.3575407
118R:R:L95 6.116559
119R:R:D99 7.005459
120R:R:L102 6.79254266
121R:R:L106 4.15608
122R:R:F131 5.3554265
123R:R:I133 3.395406
124R:R:R149 6.816509
125R:R:Y150 6.9865278
126R:R:F182 8.87405
127R:R:P227 4.06409
128R:R:Y235 8.1275408
129R:R:L242 2.9175408
130R:R:F264 8.82459
131R:R:W268 11.135659
132R:R:Y271 7.92167656
133R:R:H272 10.568558
134R:R:M281 4403
135R:R:D282 6.61754282
136R:R:R292 5.076503
137R:R:Y308 6.53254266
138R:R:H310 6.236559
139R:R:F325 6.164258
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I93 B:B:P94 42.98633.39YesNo075
2B:B:K78 B:B:P94 43.92743.35YesNo085
3B:B:D76 B:B:K78 46.75495.53YesYes098
4B:B:D76 B:B:H54 50.76596.3YesYes1599
5B:B:H54 B:B:S72 30.70828.37YesNo099
6B:B:S72 B:B:W82 24.59874.94NoYes099
7B:B:H54 B:B:I80 24.194811.93YesNo098
8B:B:I80 B:B:W82 25.047912.92NoYes089
9A:A:Q205 A:A:S207 15.37362.89NoNo098
10A:A:S207 B:B:Y145 15.31213.82NoYes088
11B:B:D186 B:B:Y145 14.02735.75YesYes698
12B:B:D186 B:B:G185 13.75611.68YesNo095
13B:B:D205 B:B:G185 13.64111.68YesNo095
14B:B:D205 B:B:H183 13.29135.04YesYes499
15B:B:H183 B:B:W211 12.4546.35YesYes498
16B:B:F199 B:B:W211 12.16839.02YesYes498
17B:B:F199 B:B:L190 11.98937.31YesNo095
18B:B:C148 B:B:L190 11.99793.17NoNo065
19B:B:C148 B:B:R150 12.13544.18NoNo066
20B:B:H62 B:B:R150 12.324311.28NoNo066
21B:B:H62 B:B:Y105 12.32163.27NoYes066
22B:B:V71 B:B:Y105 12.32516.31YesYes086
23A:A:Q205 B:B:L117 11.28573.99NoNo099
24A:A:L36 A:A:V34 10.11112.98YesYes1374
25A:A:V34 R:R:Y160 10.71625.05YesNo1345
26A:A:I343 R:R:Y160 21.42636.04YesNo085
27A:A:I343 A:A:N347 31.29344.25YesNo088
28A:A:N347 R:R:N152 31.49226.81NoNo088
29A:A:C351 R:R:N152 31.69084.72NoNo048
30A:A:C351 R:R:T88 88.66123.38NoNo048
31R:R:D89 R:R:T88 89.65672.89NoNo088
32R:R:D89 R:R:L85 89.98818.14NoNo086
33R:R:L85 R:R:R81 1003.64NoYes065
34R:R:R81 R:R:T83 91.67697.76YesNo2456
35B:B:F335 R:R:T83 91.97543.89NoNo046
36B:B:F335 B:B:R52 18.45896.41NoNo047
37B:B:R52 B:B:T50 18.44839.06NoNo073
38B:B:K337 B:B:T50 18.58056.01YesNo063
39B:B:K337 B:B:W339 37.11656.96YesYes869
40B:B:L308 B:B:W339 59.76549.11YesYes079
41B:B:L308 B:B:M45 56.18197.07YesNo074
42B:B:M45 B:B:N340 56.06234.21NoYes049
43B:B:N340 G:G:F61 54.55976.04YesYes398
44B:B:R49 G:G:F61 21.54966.41NoYes378
45B:B:R49 B:B:T87 21.43513.88NoNo075
46B:B:L51 B:B:T87 21.32042.95NoNo095
47B:B:L51 B:B:W82 14.373713.67NoYes099
48A:A:L36 A:A:T220 10.10212.95YesYes1377
49A:A:T220 R:R:Y160 10.50963.75YesNo1375
50B:B:D333 B:B:F335 73.64645.97NoNo094
51B:B:D333 B:B:H311 55.33512.61NoYes899
52B:B:H311 B:B:K337 18.56937.86YesYes896
53B:B:H311 B:B:T329 37.17389.58YesYes098
54B:B:T329 B:B:W339 22.6247.28YesYes089
55B:B:C294 B:B:T329 22.60283.38YesYes058
56B:B:C294 B:B:L308 41.23743.17YesYes057
57B:B:D333 B:B:S331 18.44675.89NoNo899
58B:B:S331 B:B:V315 18.45664.85NoNo897
59B:B:C294 B:B:V315 18.54065.12YesNo857
60B:B:S84 G:G:F61 15.76916.61NoYes358
61B:B:S84 B:B:W63 15.63884.94NoYes357
62B:B:L70 B:B:W63 37.727310.25NoYes057
63B:B:L70 B:B:W82 37.45013.42NoYes059
64B:B:I338 G:G:F61 15.76895.02YesYes358
65B:B:I338 B:B:W63 15.63954.7YesYes357
66A:A:I223 A:A:L36 19.3925.71YesYes077
67A:A:N270 A:A:T324 16.10754.39NoYes099
68A:A:F268 A:A:T324 14.45143.89YesYes1899
69A:A:I223 A:A:I266 11.14282.94YesNo078
70B:B:C149 B:B:L146 11.33433.17NoYes787
71B:B:C149 B:B:T102 21.59476.76NoNo088
72B:B:C148 B:B:T102 21.67183.38NoNo068
73A:A:C215 B:B:L117 11.03763.17NoNo069
74A:A:C215 A:A:H214 11.05882.95NoYes068
75A:A:H214 B:B:W332 11.19164.23YesYes989
76R:R:R328 R:R:R81 15.24949.6NoYes055
77A:A:C351 R:R:R149 61.80985.57NoYes049
78R:R:R149 R:R:Y235 27.59857.2YesYes098
79B:B:R283 G:G:L51 49.97223.64YesYes1496
80B:B:I37 B:B:R283 24.85023.76YesYes029
81B:B:I37 B:B:T34 23.9747.6YesNo025
82B:B:L30 B:B:T34 47.57172.95YesNo055
83B:B:L261 B:B:L30 28.36132.77NoYes055
84B:B:D254 B:B:L261 27.79355.43NoNo095
85B:B:A257 B:B:D254 27.0694.63NoNo079
86B:B:A257 B:B:Q259 26.70663.03NoYes076
87B:B:Q259 B:B:R22 24.53035.84YesNo066
88B:B:L300 B:B:R283 24.3064.86NoYes069
89B:B:L300 B:B:T34 23.95554.42NoNo065
90B:B:D258 B:B:R22 15.79144.76YesNo076
91B:B:L30 B:B:M262 16.73037.07YesYes054
92B:B:L79 B:B:V71 13.59224.47YesYes078
93B:B:I93 B:B:L79 21.97344.28YesYes1077
94B:B:C121 B:B:C149 10.18323.64YesNo788
95B:B:I157 B:B:W169 18.82443.52NoYes078
96B:B:D258 B:B:F222 13.59654.78YesYes278
97B:B:M262 B:B:Y264 15.63535.99YesYes045
98B:B:L285 B:B:Y264 10.30235.86YesYes065
99B:B:L308 B:B:V296 46.56072.98YesNo075
100B:B:L284 B:B:V296 44.89745.96NoNo055
101B:B:L284 G:G:L51 43.6584.15NoYes056
102B:B:N313 B:B:W332 11.94599.04NoYes079
103R:R:L78 R:R:L85 10.11922.77NoNo076
104R:R:R149 R:R:Y318 27.5164.12YesNo099
105R:R:L142 R:R:Y318 26.572914.07NoNo089
106R:R:S146 R:R:Y235 26.34618.9NoYes098
107R:R:M231 R:R:S146 24.26586.13NoNo089
108R:R:F264 R:R:M231 47.88018.71YesNo098
109R:R:F264 R:R:W268 45.911216.04YesYes599
110R:R:F135 R:R:W268 16.385325.05NoYes579
111R:R:F135 R:R:Y271 15.98853.09NoYes576
112R:R:Q219 R:R:Y271 12.82067.89NoYes056
113R:R:Q219 R:R:Y136 12.020715.78NoNo056
114R:R:F182 R:R:Y136 16.811212.38YesNo056
115R:R:L142 R:R:M231 24.12195.65NoNo088
116R:R:H272 R:R:W268 18.38534.23YesYes589
117R:R:H272 R:R:Y271 16.004613.07YesYes586
118R:R:V275 R:R:Y271 16.82787.57NoYes556
119R:R:I279 R:R:V275 16.02843.07NoNo055
120R:R:I279 R:R:R216 14.42723.76NoNo053
121R:R:D282 R:R:R216 12.82494.76YesNo2823
122R:R:D282 R:R:M281 11.22371.39YesYes023
123B:B:F292 B:B:N313 11.9032.42NoNo047
124B:B:F292 R:R:M331 11.86031.24NoNo044
125B:B:I93 B:B:Y124 13.45784.84YesYes1076
126R:R:M331 R:R:R328 11.99531.24NoNo045
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XXZ
Class A
SubFamily Protein
Type Chemokine
SubType CXCR3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.3
Date 2025-02-26
D.O.I. doi.org/10.1038/s41467-025-58264-w
Net Summary
Imin 2.89
Number of Linked Nodes 779
Number of Links 908
Number of Hubs 139
Number of Links mediated by Hubs 502
Number of Communities 28
Number of Nodes involved in Communities 171
Number of Links involved in Communities 230
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 3004620
Length Of Smallest Path 3
Average Path Length 33.2528
Length of Longest Path 60
Minimum Path Strength 1.24
Average Path Strength 5.81762
Maximum Path Strength 25.7333
Minimum Path Correlation 0.7
Average Path Correlation 0.989891
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 45.0431
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6927
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • adenylate cyclase regulator activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • signaling receptor activity   • G protein-coupled chemoattractant receptor activity   • C-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • chemokine binding   • cytokine binding   • C-X-C chemokine receptor activity   • C-C chemokine binding   • C-X-C chemokine binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • cell adhesion   • regulation of cell adhesion   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • blood vessel development   • immune response   • immune system process   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of biological process   • response to external stimulus   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • taxis   • regulation of response to stimulus   • regulation of locomotion   • locomotion   • apoptotic process   • cell death   • programmed cell death   • calcium-mediated signaling   • positive regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • positive regulation of apoptotic process   • regulation of execution phase of apoptosis   • positive regulation of execution phase of apoptosis   • execution phase of apoptosis   • positive regulation of cellular process   • negative regulation of programmed cell death   • negative regulation of biological process   • negative regulation of execution phase of apoptosis   • negative regulation of apoptotic process   • negative regulation of cellular process   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • cell chemotaxis   • cell migration   • cell motility   • cell surface receptor signaling pathway   • regulation of developmental process   • regulation of vasculature development   • positive regulation of developmental process   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • positive regulation of angiogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • positive regulation of multicellular organismal process   • regulation of calcium ion transport   • regulation of localization   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • intracellular calcium ion homeostasis   • calcium ion transport   • localization   • positive regulation of monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation homeostasis   • monoatomic cation transport   • intracellular monoatomic ion homeostasis   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • establishment of localization   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • chemical homeostasis   • cellular localization   • inorganic ion homeostasis   • transport   • homeostatic process   • monoatomic ion transmembrane transport   • calcium ion homeostasis   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • maintenance of location in cell   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • intracellular chemical homeostasis   • positive regulation of release of sequestered calcium ion into cytosol   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • calcium ion transmembrane import into cytosol   • regulation of transport   • sequestering of calcium ion   • cellular homeostasis   • positive regulation of transport   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • defense response   • response to stress   • inflammatory response   • negative regulation of blood vessel morphogenesis   • negative regulation of developmental process   • negative regulation of angiogenesis   • negative regulation of vasculature development   • negative regulation of multicellular organismal process   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • regulation of transcription by RNA polymerase II   • primary metabolic process   • regulation of macromolecule metabolic process   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • regulation of gene expression   • biosynthetic process   • positive regulation of RNA biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of DNA-templated transcription   • regulation of metabolic process   • regulation of cell motility   • regulation of leukocyte migration   • leukocyte migration   • regulation of cell migration   • regulation of immune system process   • lymphocyte chemotaxis   • lymphocyte migration   • mononuclear cell migration   • T cell chemotaxis   • T cell migration   • leukocyte chemotaxis   • negative regulation of cell population proliferation   • endothelial cell proliferation   • negative regulation of endothelial cell proliferation   • regulation of endothelial cell proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • negative regulation of epithelial cell proliferation   • cell surface   • external side of plasma membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8XXZ_Chain_A
TLSAEERAA LERSKAIEK NLKEDGISA AKDVKLLLL GASGKSTIV 
KQMKIITGI VETHFTFKN LHFRLFDVG GQRSERKKW IHCFEDVTA 
IIFCVLSYN RMHESLMLF DSICNNKFF IDTSIILFL NKKDLFGEK 
IKKSPLTIC FPEYTGPNT YEDAAAYIQ AQFESKNRS PNKEIYCHM 
TCATDTNNQ VFDAVTDII IANNLRGCG LYDNDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XXZ_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XXZ_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49682
Sequence
>8XXZ_Chain_R
LYSLLFLLG LLGNGAVAA VLLSRRTAL SSTDTFLLH LAVADTLLV 
LTLPLWAVA GALFNINFY AGALLLACI SFDRYLNIV HATQLYRPA 
RVTLTCLAV WGLCLLFAL PDFIPQVGR TALRVLQLV AGFLLPLLV 
MAYCYAHIL AVLLVSRGQ RRLRAMRLV VVVVVAFAL CWTPYHLVV 
LVDILMDLG ALARNCGRE SRVDVAKSV TSGLGYMHC CLNPLLYAF 
VGVKFRERM WML


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HNKAProteinChemokineCXCR3Homo sapiensCXCL11-Gi1/β1/γ23.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNK (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL11-3.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNLAProteinChemokineCXCR3Homo sapiensPS372424-Gi1/β1/γ22.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNL (No Gprot) AProteinChemokineCXCR3Homo sapiensPS372424-2.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNMAProteinChemokineCXCR3Homo sapiensVUF11222-Gi1/β1/γ22.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNM (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11222-2.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNNAProteinChemokineCXCR3Homo sapiensSCH546738--3.62023-11-29doi.org/10.1038/s41594-023-01175-5
8K2WAProteinChemokineCXCR3Homo sapiensAMG487--32023-11-29doi.org/10.1038/s41594-023-01175-5
8K2XAProteinChemokineCXCR3Homo sapiensCXCL10-Gi1/β1/γ23.22023-11-29doi.org/10.1038/s41594-023-01175-5
8K2X (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL10-3.22023-11-29doi.org/10.1038/s41594-023-01175-5
8XXYAProteinChemokineCXCR3Homo sapiens---3.682025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZAProteinChemokineCXCR3Homo sapiens--Go/β1/γ23.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZ (No Gprot) AProteinChemokineCXCR3Homo sapiens--3.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XYIAProteinChemokineCXCR3Homo sapiensVUF10661--3.162025-02-26doi.org/10.1038/s41467-025-58264-w
8XYKAProteinChemokineCXCR3Homo sapiensVUF10661-Go/β1/γ23.032025-02-26doi.org/10.1038/s41467-025-58264-w
8XYK (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF10661-3.032025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0HAProteinChemokineCXCR3Homo sapiensVUF11418--3.532025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0NAProteinChemokineCXCR3Homo sapiensVUF11418-Go/β1/γ23.072025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0N (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11418-3.072025-02-26doi.org/10.1038/s41467-025-58264-w




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