Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F51 4.885405
2R:R:L56 4.114515
3R:R:Y60 5.585418
4R:R:F64 6.1825407
5R:R:V74 4.384549
6R:R:L78 3.5125447
7R:R:F91 5.435627
8R:R:L95 6.1775429
9R:R:D99 7.965429
10R:R:W109 8.58143715
11R:R:W117 8.05167619
12R:R:F119 6.738507
13R:R:F131 8.62515
14R:R:I133 2.4275406
15R:R:Y136 5.142506
16R:R:D148 5.13408
17R:R:Y150 5.39286738
18R:R:V168 6.61428
19R:R:F182 3.865405
20R:R:L190 5.0775415
21R:R:C203 5.295419
22R:R:Y205 7.07667613
23R:R:F207 9.52333614
24R:R:L220 3.26424
25R:R:F224 8.2775428
26R:R:M231 6.405428
27R:R:Y235 5.535828
28R:R:I238 3.395408
29R:R:R250 4.8575406
30R:R:F264 5.9775429
31R:R:W268 6.41529
32R:R:Y271 9.2625406
33R:R:H272 7.915428
34R:R:R292 7.6475463
35R:R:H310 7.11429
36R:R:Y318 6.164529
37R:R:F325 8.675448
38R:R:M329 3.915406
39L:L:?1 9.815831210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D297 R:R:S48 16.52552.94NoNo044
2R:R:D297 R:R:D52 19.29742.66NoNo045
3R:R:D52 R:R:F51 25.29363.58NoYes055
4R:R:F51 R:R:F55 37.064510.72YesNo054
5R:R:F55 R:R:L56 38.36384.87NoYes045
6R:R:L59 R:R:Y60 29.7695.86NoYes068
7L:L:?1 R:R:L56 42.87783.47YesYes105
8R:R:L59 R:R:L63 29.01834.15NoNo067
9R:R:L63 R:R:M309 14.35032.83NoNo075
10R:R:C312 R:R:L63 34.71613.17NoNo087
11R:R:C312 R:R:G67 28.57561.96NoNo088
12R:R:G67 R:R:V103 25.47641.84NoNo086
13R:R:L68 R:R:V103 19.22042.98NoNo066
14R:R:F64 R:R:L68 12.887410.96YesNo076
15L:L:?1 R:R:F131 50.837310.7YesYes105
16R:R:F131 R:R:L102 37.237712.18YesNo056
17R:R:C311 R:R:L102 37.29553.17NoNo086
18R:R:C311 R:R:D99 37.75756.22NoYes089
19R:R:D99 R:R:N71 87.4886.73YesNo099
20R:R:N71 R:R:P315 82.19449.77NoNo099
21L:L:?1 R:R:W109 90.827730.73YesYes105
22R:R:T105 R:R:W109 37.47834.85NoYes175
23R:R:L130 R:R:T105 63.64772.95NoNo157
24R:R:L101 R:R:L130 54.76422.77NoNo155
25R:R:L101 R:R:V97 50.85661.49NoNo056
26R:R:L93 R:R:V97 46.62171.49NoNo066
27R:R:L78 R:R:L93 42.09824.15YesNo076
28R:R:F131 R:R:T105 30.51973.89YesNo157
29R:R:L78 R:R:V74 31.31862.98YesYes479
30R:R:A96 R:R:V74 13.09913.39NoYes099
31R:R:F320 R:R:F325 48.373410.72NoYes078
32R:R:F320 R:R:P315 74.19632.89NoNo079
33R:R:F325 R:R:V77 17.69017.87YesNo087
34R:R:F320 R:R:M329 24.46583.73NoYes076
35R:R:M329 R:R:V77 15.90953.04YesNo067
36R:R:L332 R:R:V77 26.09242.98NoNo057
37R:R:L78 R:R:L85 33.27242.77YesNo076
38R:R:L332 R:R:S80 19.9236.01NoNo055
39R:R:L85 R:R:R81 21.0787.29NoNo065
40R:R:R328 R:R:R81 12.560218.13NoNo055
41R:R:R335 R:R:S80 13.29161.32NoNo045
42R:R:P165 R:R:R167 18.69111.53NoNo024
43R:R:P164 R:R:P165 28.67181.95NoNo062
44R:R:P164 R:R:R161 48.575614.41NoNo064
45R:R:A166 R:R:R161 57.184.15NoNo044
46R:R:A166 R:R:S87 67.08371.71NoNo046
47R:R:D148 R:R:S87 38.49867.36YesNo086
48R:R:D148 R:R:F91 51.91534.78YesYes087
49R:R:C144 R:R:F91 63.53225.59NoYes077
50R:R:C144 R:R:V175 64.40811.71NoNo077
51R:R:C179 R:R:V175 67.68051.71NoNo087
52R:R:C179 R:R:Y136 70.22142.69NoYes086
53R:R:F135 R:R:Y136 47.30517.22NoYes076
54L:L:?1 R:R:F135 94.5149.93YesNo007
55R:R:S87 R:R:V168 38.54674.85NoYes068
56R:R:F91 R:R:V168 48.209810.49YesYes278
57R:R:Q219 R:R:Y136 37.00676.76NoYes056
58L:L:?1 R:R:Q219 38.132810.02YesNo005
59R:R:F91 R:R:I145 59.36483.77YesNo279
60R:R:F135 R:R:W268 69.35516.01NoYes079
61R:R:F264 R:R:W268 65.68827.02YesYes299
62R:R:F264 R:R:M231 90.63528.71YesYes298
63R:R:L142 R:R:M231 30.3085.65NoYes088
64R:R:L142 R:R:Y318 43.04147.03NoYes089
65R:R:I145 R:R:Y318 41.57846.04NoYes299
66R:R:M231 R:R:Y235 97.29553.59YesYes288
67R:R:Y235 R:R:Y318 40.66412.98YesYes289
68R:R:R149 R:R:Y235 22.21376.17NoYes298
69R:R:I145 R:R:R149 21.0016.26NoNo299
70R:R:C172 R:R:F91 27.7192.79NoYes077
71R:R:D99 R:R:L95 69.4618.14YesYes299
72R:R:L141 R:R:L95 48.70075.54NoYes089
73R:R:H94 R:R:L141 45.89033.86NoNo098
74R:R:H310 R:R:W268 23.68627.41YesYes299
75R:R:H310 R:R:N314 31.78067.65YesNo299
76R:R:L95 R:R:N314 16.34265.49YesNo299
77R:R:H94 R:R:W176 42.49286.35NoNo099
78R:R:W109 R:R:W117 73.84996.56YesYes159
79R:R:D112 R:R:W117 29.268510.05NoYes059
80R:R:D112 R:R:H202 26.034616.39NoNo053
81R:R:F119 R:R:W117 48.315721.05YesYes079
82R:R:F119 R:R:V118 35.72673.93YesNo073
83R:R:Q116 R:R:V118 32.53134.3NoNo033
84R:R:Q116 R:R:T201 20.02894.25NoNo035
85R:R:L190 R:R:Y205 14.21569.38YesYes153
86L:L:?1 R:R:Y205 39.31677.36YesYes103
87R:R:I133 R:R:W176 25.47642.35YesNo069
88R:R:A137 R:R:W176 13.1285.19NoNo079
89R:R:A143 R:R:V230 19.19153.39NoNo077
90R:R:C234 R:R:V230 22.9741.71NoNo077
91R:R:C234 R:R:Y150 26.46785.38NoYes378
92R:R:I238 R:R:Y150 62.822.42YesYes088
93R:R:I238 R:R:Y235 1002.42YesYes088
94R:R:L151 R:R:Y150 11.45333.52NoYes358
95R:R:G163 R:R:P164 10.00964.06NoNo066
96R:R:F182 R:R:Y136 20.49092.06YesYes056
97R:R:F207 R:R:Y205 31.08767.22YesYes143
98R:R:F189 R:R:F207 10.558225.72NoYes054
99R:R:D195 R:R:H202 10.09621.26NoNo023
100R:R:A200 R:R:H202 12.90664.39NoNo013
101L:L:?1 R:R:R216 48.21944.57YesNo003
102R:R:K300 R:R:R216 30.96253.71NoNo053
103L:L:?1 R:R:Y271 28.257915.45YesYes006
104R:R:H272 R:R:Y271 17.69016.53YesYes086
105R:R:H272 R:R:L220 23.42643.86YesYes284
106R:R:A143 R:R:P227 15.38981.87NoNo079
107R:R:F264 R:R:L228 19.48993.65YesNo097
108R:R:F224 R:R:L228 17.58424.87YesNo087
109R:R:T303 R:R:Y271 14.98566.24NoYes076
110R:R:V257 R:R:Y235 19.04728.83NoYes078
111R:R:I238 R:R:L242 33.94612.85YesNo088
112R:R:L239 R:R:V257 15.26474.47NoNo057
113R:R:L242 R:R:M254 26.53514.24NoNo086
114R:R:M254 R:R:R250 15.27434.96NoYes066
115R:R:L239 R:R:V258 11.47261.49NoNo055
116R:R:C267 R:R:L306 17.38213.17NoNo098
117R:R:L306 R:R:M309 15.12992.83NoNo085
118R:R:I279 R:R:R216 15.96732.51NoNo053
119R:R:L276 R:R:L280 20.56791.38NoNo054
120R:R:L220 R:R:L276 24.69681.38YesNo045
121R:R:K300 R:R:V296 19.86534.55NoNo054
122R:R:M281 R:R:V296 16.77571.52NoNo034
123R:R:M281 R:R:R292 11.72287.44NoYes633
124R:R:N289 R:R:R292 11.626612.05NoYes053
125R:R:A192 R:R:T201 10.09621.68NoNo055
126R:R:C267 R:R:H310 20.50058.85NoYes099
127L:L:?1 R:R:Y60 34.45626.62YesYes108
128R:R:D99 R:R:N314 15.803710.77YesNo299
129R:R:F325 R:R:V74 30.26959.18YesYes489
130R:R:F264 R:R:H310 13.5134.53YesYes299
131R:R:L142 R:R:L95 55.68825.54NoYes089
132R:R:C172 R:R:H94 26.169410.32NoNo079
133R:R:H272 R:R:W268 25.46683.17YesYes289
134R:R:L280 R:R:L286 12.09821.38NoNo041
135R:R:F131 R:R:W109 13.6676.01YesYes155
136R:R:F224 R:R:L220 10.01923.65YesYes284
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F55 R:R:L56 4.87 0 No Yes 4 5 2 1
R:R:F55 R:R:L59 7.31 0 No No 4 6 2 2
R:R:L56 R:R:Y60 5.86 1 Yes Yes 5 8 1 1
R:R:A113 R:R:L56 4.73 1 No Yes 5 5 1 1
L:L:?1 R:R:L56 3.47 1 Yes Yes 0 5 0 1
R:R:L59 R:R:Y60 5.86 0 No Yes 6 8 2 1
R:R:A110 R:R:Y60 4 0 No Yes 7 8 2 1
L:L:?1 R:R:Y60 6.62 1 Yes Yes 0 8 0 1
R:R:F131 R:R:L102 12.18 1 Yes No 5 6 1 2
R:R:T105 R:R:W109 4.85 1 No Yes 7 5 2 1
R:R:F131 R:R:T105 3.89 1 Yes No 5 7 1 2
R:R:W109 R:R:W117 6.56 1 Yes Yes 5 9 1 2
R:R:A127 R:R:W109 3.89 0 No Yes 5 5 2 1
R:R:G128 R:R:W109 2.81 0 No Yes 6 5 2 1
R:R:F131 R:R:W109 6.01 1 Yes Yes 5 5 1 1
R:R:C203 R:R:W109 5.22 1 Yes Yes 9 5 2 1
L:L:?1 R:R:W109 30.73 1 Yes Yes 0 5 0 1
L:L:?1 R:R:A113 5.93 1 Yes No 0 5 0 1
R:R:C203 R:R:W117 3.92 1 Yes Yes 9 9 2 2
R:R:F131 R:R:Y308 10.32 1 Yes No 5 6 1 1
L:L:?1 R:R:F131 10.7 1 Yes Yes 0 5 0 1
R:R:N132 R:R:Y136 6.98 1 No Yes 4 6 2 2
R:R:D186 R:R:N132 13.46 1 No No 4 4 2 2
R:R:N132 R:R:Y205 3.49 1 No Yes 4 3 2 1
R:R:F135 R:R:Y136 7.22 0 No Yes 7 6 1 2
R:R:F135 R:R:W268 6.01 0 No Yes 7 9 1 2
L:L:?1 R:R:F135 9.93 1 Yes No 0 7 0 1
R:R:Q219 R:R:Y136 6.76 0 No Yes 5 6 1 2
R:R:D186 R:R:Y205 11.49 1 No Yes 4 3 2 1
R:R:C203 R:R:L190 4.76 1 Yes Yes 9 5 2 2
R:R:L190 R:R:Y205 9.38 1 Yes Yes 5 3 2 1
R:R:F207 R:R:Y205 7.22 1 Yes Yes 4 3 2 1
R:R:L215 R:R:Y205 3.52 1 No Yes 5 3 2 1
L:L:?1 R:R:Y205 7.36 1 Yes Yes 0 3 0 1
R:R:F207 R:R:L215 10.96 1 Yes No 4 5 2 2
R:R:K300 R:R:R216 3.71 0 No No 5 3 2 1
L:L:?1 R:R:R216 4.57 1 Yes No 0 3 0 1
L:L:?1 R:R:Q219 10.02 1 Yes No 0 5 0 1
R:R:H272 R:R:W268 3.17 2 Yes Yes 8 9 2 2
R:R:H272 R:R:Y271 6.53 2 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 8.83 0 No Yes 5 6 2 1
R:R:T303 R:R:Y271 6.24 0 No Yes 7 6 2 1
L:L:?1 R:R:Y271 15.45 1 Yes Yes 0 6 0 1
R:R:S304 R:R:Y308 7.63 1 No No 5 6 1 1
L:L:?1 R:R:S304 5.65 1 Yes No 0 5 0 1
L:L:?1 R:R:Y308 7.36 1 Yes No 0 6 0 1
R:R:I279 R:R:R216 2.51 0 No No 5 3 2 1
R:R:G305 R:R:S304 1.86 0 No No 5 5 2 1
R:R:L56 R:R:P57 1.64 1 Yes No 5 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XYK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.77
Number of Linked Nodes 264
Number of Links 303
Number of Hubs 39
Number of Links mediated by Hubs 155
Number of Communities 6
Number of Nodes involved in Communities 58
Number of Links involved in Communities 82
Path Summary
Number Of Nodes in MetaPath 137
Number Of Links MetaPath 136
Number of Shortest Paths 52216
Length Of Smallest Path 3
Average Path Length 11.7724
Length of Longest Path 24
Minimum Path Strength 1.38
Average Path Strength 6.0696
Maximum Path Strength 19.4467
Minimum Path Correlation 0.7
Average Path Correlation 0.9238
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 50.0967
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.7391
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP49682
Sequence
>8XYK_nogp_Chain_R
DFSLNFDRA FLPALYSLL FLLGLLGNG AVAAVLLSR RTALSSTDT 
FLLHLAVAD TLLVLTLPL WAVDAAVQW VFGSGLCKV AGALFNINF 
YAGALLLAC ISFDRYLNI VHATQLYRR GPPARVTLT CLAVWGLCL 
LFALPDFIF LSAHHDERL NATHCQYNF PQVGRTALR VLQLVAGFL 
LPLLVMAYC YAHILAVLL VSRGQRRLR AMRLVVVVV VAFALCWTP 
YHLVVLVDI LMDLGALAR NCGRESRVD VAKSVTSGL GYMHCCLNP 
LLYAFVGVK FRERMWMLL LR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HNKAProteinChemokineCXCR3Homo sapiensCXCL11-Gi1/β1/γ23.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNK (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL11-3.012023-11-29doi.org/10.1038/s41594-023-01175-5
8HNLAProteinChemokineCXCR3Homo sapiensPS372424-Gi1/β1/γ22.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNL (No Gprot) AProteinChemokineCXCR3Homo sapiensPS372424-2.982023-11-29doi.org/10.1038/s41594-023-01175-5
8HNMAProteinChemokineCXCR3Homo sapiensVUF11222-Gi1/β1/γ22.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNM (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11222-2.942023-11-29doi.org/10.1038/s41594-023-01175-5
8HNNAProteinChemokineCXCR3Homo sapiens-SCH546738-3.62023-11-29doi.org/10.1038/s41594-023-01175-5
8K2WAProteinChemokineCXCR3Homo sapiensAMG487--32023-11-29doi.org/10.1038/s41594-023-01175-5
8K2XAProteinChemokineCXCR3Homo sapiensCXCL10-Gi1/β1/γ23.22023-11-29doi.org/10.1038/s41594-023-01175-5
8K2X (No Gprot) AProteinChemokineCXCR3Homo sapiensCXCL10-3.22023-11-29doi.org/10.1038/s41594-023-01175-5
8XXYAProteinChemokineCXCR3Homo sapiens---3.682025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZAProteinChemokineCXCR3Homo sapiens--Go/β1/γ23.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XXZ (No Gprot) AProteinChemokineCXCR3Homo sapiens--3.32025-02-26doi.org/10.1038/s41467-025-58264-w
8XYIAProteinChemokineCXCR3Homo sapiensVUF10661--3.162025-02-26doi.org/10.1038/s41467-025-58264-w
8XYKAProteinChemokineCXCR3Homo sapiensVUF10661-Go/β1/γ23.032025-02-26doi.org/10.1038/s41467-025-58264-w
8XYK (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF10661-3.032025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0HAProteinChemokineCXCR3Homo sapiensVUF11418--3.532025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0NAProteinChemokineCXCR3Homo sapiensVUF11418-Go/β1/γ23.072025-02-26doi.org/10.1038/s41467-025-58264-w
8Y0N (No Gprot) AProteinChemokineCXCR3Homo sapiensVUF11418-3.072025-02-26doi.org/10.1038/s41467-025-58264-w




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Download 8XYK_nogp.zip



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