psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D46	R:R:N50	9.42	No	No	0	4	4
2	R:R:L49	R:R:S48	3	No	No	0	3	4
3	R:R:S294	R:R:S48	4.89	No	No	0	3	4
4	R:R:D297	R:R:S48	2.94	No	No	0	4	4
5	R:R:D52	R:R:F51	3.58	No	Yes	0	5	5
6	R:R:F51	R:R:F55	10.72	Yes	No	0	5	4
7	R:R:D52	R:R:S301	5.89	No	No	0	5	4
8	R:R:F55	R:R:L56	4.87	No	Yes	0	4	5
9	R:R:F55	R:R:L59	7.31	No	No	0	4	6
10	R:R:L56	R:R:Y60	5.86	Yes	Yes	1	5	8
11	R:R:A113	R:R:L56	4.73	No	Yes	1	5	5
12	L:L:?1	R:R:L56	3.13	Yes	Yes	1	0	5
13	R:R:L59	R:R:Y60	5.86	No	Yes	0	6	8
14	R:R:L59	R:R:L63	4.15	No	No	0	6	7
15	R:R:A110	R:R:Y60	4	No	Yes	0	7	8
16	L:L:?1	R:R:Y60	5.96	Yes	Yes	1	0	8
17	R:R:L63	R:R:M309	2.83	No	No	0	7	5
18	R:R:C312	R:R:L63	3.17	No	No	0	8	7
19	R:R:F64	R:R:L68	10.96	Yes	No	0	7	6
20	R:R:F64	R:R:P107	10.11	Yes	No	0	7	9
21	R:R:C312	R:R:L66	6.35	No	No	0	8	6
22	R:R:L68	R:R:V103	2.98	No	No	0	6	6
23	R:R:D99	R:R:N71	6.73	Yes	No	0	9	9
24	R:R:N71	R:R:T100	4.39	No	No	0	9	7
25	R:R:N71	R:R:P315	9.77	No	No	0	9	9
26	R:R:L78	R:R:V74	2.98	Yes	Yes	4	7	9
27	R:R:L92	R:R:V74	2.98	No	Yes	4	8	9
28	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
29	R:R:A319	R:R:V74	3.39	No	Yes	4	7	9
30	R:R:F325	R:R:V74	9.18	Yes	Yes	4	8	9
31	R:R:F325	R:R:V77	7.87	Yes	No	0	8	7
32	R:R:M329	R:R:V77	3.04	Yes	No	0	6	7
33	R:R:L332	R:R:V77	2.98	No	No	0	5	7
34	R:R:L78	R:R:L85	2.77	Yes	No	0	7	6
35	R:R:L78	R:R:L92	4.15	Yes	No	4	7	8
36	R:R:L78	R:R:L93	4.15	Yes	No	0	7	6
37	R:R:L79	R:R:L93	4.15	No	No	0	4	6
38	R:R:L332	R:R:S80	6.01	No	No	0	5	5
39	R:R:R81	R:R:T83	9.06	No	No	0	5	6
40	R:R:L85	R:R:R81	7.29	No	No	0	6	5
41	R:R:R328	R:R:R81	18.13	No	No	0	5	5
42	R:R:R335	R:R:R82	11.73	No	No	0	4	5
43	R:R:A84	R:R:R167	4.15	No	No	0	7	4
44	R:R:D89	R:R:L85	8.14	No	No	0	8	6
45	R:R:D89	R:R:S86	10.31	No	No	0	8	7
46	R:R:D148	R:R:S87	7.36	Yes	No	0	8	6
47	R:R:S87	R:R:V168	4.85	No	Yes	0	6	8
48	R:R:D148	R:R:T88	4.34	Yes	No	0	8	8
49	R:R:T90	R:R:V168	3.17	No	Yes	0	6	8
50	R:R:C144	R:R:F91	5.59	No	Yes	0	7	7
51	R:R:F91	R:R:I145	3.77	Yes	No	2	7	9
52	R:R:D148	R:R:F91	4.78	Yes	Yes	0	8	7
53	R:R:F91	R:R:V168	10.49	Yes	Yes	2	7	8
54	R:R:F91	R:R:T171	5.19	Yes	No	2	7	5
55	R:R:C172	R:R:F91	2.79	No	Yes	0	7	7
56	R:R:A319	R:R:L92	4.73	No	No	4	7	8
57	R:R:H94	R:R:L141	3.86	No	No	0	9	8
58	R:R:C172	R:R:H94	10.32	No	No	0	7	9
59	R:R:H94	R:R:W176	6.35	No	No	0	9	9
60	R:R:D99	R:R:L95	8.14	Yes	Yes	2	9	9
61	R:R:L141	R:R:L95	5.54	No	Yes	0	8	9
62	R:R:L142	R:R:L95	5.54	No	Yes	0	8	9
63	R:R:L95	R:R:N314	5.49	Yes	No	2	9	9
64	R:R:C311	R:R:D99	6.22	No	Yes	0	8	9
65	R:R:D99	R:R:N314	10.77	Yes	No	2	9	9
66	R:R:L101	R:R:L130	2.77	No	No	1	5	5
67	R:R:L101	R:R:N134	12.36	No	No	1	5	8
68	R:R:F131	R:R:L102	12.18	Yes	No	0	5	6
69	R:R:C311	R:R:L102	3.17	No	No	0	8	6
70	R:R:L106	R:R:V103	2.98	No	No	0	8	6
71	R:R:T105	R:R:W109	4.85	No	Yes	1	7	5
72	R:R:L130	R:R:T105	2.95	No	No	1	5	7
73	R:R:F131	R:R:T105	3.89	Yes	No	1	5	7
74	R:R:W109	R:R:W117	6.56	Yes	Yes	1	5	9
75	R:R:A127	R:R:W109	3.89	No	Yes	0	5	5
76	R:R:G128	R:R:W109	2.81	No	Yes	0	6	5
77	R:R:F131	R:R:W109	6.01	Yes	Yes	1	5	5
78	R:R:C203	R:R:W109	5.22	Yes	Yes	1	9	5
79	L:L:?1	R:R:W109	27.67	Yes	Yes	1	0	5
80	R:R:D112	R:R:W117	10.05	No	Yes	0	5	9
81	R:R:D112	R:R:H202	16.39	No	No	0	5	3
82	L:L:?1	R:R:A113	5.34	Yes	No	1	0	5
83	R:R:Q116	R:R:V115	4.3	No	No	0	3	4
84	R:R:Q116	R:R:V118	4.3	No	No	0	3	3
85	R:R:Q116	R:R:T201	4.25	No	No	0	3	5
86	R:R:F119	R:R:W117	21.05	Yes	Yes	0	7	9
87	R:R:G120	R:R:W117	2.81	No	Yes	0	8	9
88	R:R:C124	R:R:W117	3.92	No	Yes	1	9	9
89	R:R:C203	R:R:W117	3.92	Yes	Yes	1	9	9
90	R:R:F119	R:R:V118	3.93	Yes	No	0	7	3
91	R:R:F119	R:R:L123	4.87	Yes	No	0	7	6
92	R:R:C124	R:R:L190	4.76	No	Yes	1	9	5
93	R:R:C124	R:R:C203	7.28	No	Yes	1	9	9
94	R:R:A129	R:R:F187	8.32	No	No	0	5	4
95	R:R:L130	R:R:N134	6.87	No	No	1	5	8
96	R:R:F131	R:R:Y308	10.32	Yes	No	1	5	6
97	L:L:?1	R:R:F131	9.63	Yes	Yes	1	0	5
98	R:R:N132	R:R:Y136	6.98	No	Yes	0	4	6
99	R:R:D186	R:R:N132	13.46	No	No	1	4	4
100	R:R:N132	R:R:Y205	3.49	No	Yes	1	4	3
101	R:R:I133	R:R:L180	2.85	Yes	No	0	6	4
102	R:R:A183	R:R:I133	3.25	No	Yes	0	7	6
103	R:R:F135	R:R:Y136	7.22	No	Yes	0	7	6
104	R:R:F135	R:R:W268	6.01	No	Yes	0	7	9
105	L:L:?1	R:R:F135	8.95	Yes	No	0	0	7
106	R:R:Q219	R:R:Y136	6.76	No	Yes	0	5	6
107	R:R:A137	R:R:W176	5.19	No	No	0	7	9
108	R:R:L140	R:R:V175	5.96	No	No	0	6	7
109	R:R:L142	R:R:M231	5.65	No	Yes	0	8	8
110	R:R:L142	R:R:Y318	7.03	No	Yes	0	8	9
111	R:R:A143	R:R:V230	3.39	No	No	0	7	7
112	R:R:I145	R:R:R149	6.26	No	No	2	9	9
113	R:R:I145	R:R:Y318	6.04	No	Yes	2	9	9
114	R:R:M231	R:R:S146	7.67	Yes	No	2	8	9
115	R:R:S146	R:R:Y235	11.45	No	Yes	2	9	8
116	R:R:F147	R:R:Y150	3.09	No	Yes	3	6	8
117	R:R:F147	R:R:L151	8.53	No	No	3	6	5
118	R:R:C234	R:R:F147	2.79	No	No	3	7	6
119	R:R:D148	R:R:N152	4.04	Yes	No	0	8	8
120	R:R:R149	R:R:Y235	6.17	No	Yes	2	9	8
121	R:R:R149	R:R:Y318	7.2	No	Yes	2	9	9
122	R:R:L151	R:R:Y150	3.52	No	Yes	3	5	8
123	R:R:V154	R:R:Y150	11.36	No	Yes	3	7	8
124	R:R:H155	R:R:Y150	7.62	No	Yes	3	6	8
125	R:R:C234	R:R:Y150	5.38	No	Yes	3	7	8
126	R:R:H237	R:R:Y150	4.36	No	Yes	0	4	8
127	R:R:L151	R:R:L159	5.54	No	No	0	5	6
128	R:R:I153	R:R:I238	5.89	No	Yes	0	8	8
129	R:R:H155	R:R:V154	8.3	No	No	3	6	7
130	R:R:V154	R:R:V241	6.41	No	No	0	7	5
131	R:R:P164	R:R:R161	14.41	No	No	0	6	4
132	R:R:A166	R:R:R161	4.15	No	No	0	4	4
133	R:R:G163	R:R:P164	4.06	No	No	0	6	6
134	R:R:P165	R:R:R167	11.53	No	No	0	2	4
135	R:R:T171	R:R:V168	7.93	No	Yes	2	5	8
136	R:R:F182	R:R:L178	7.31	Yes	No	0	5	4
137	R:R:F182	R:R:L218	4.87	Yes	No	0	5	3
138	R:R:F207	R:R:P185	2.89	Yes	No	1	4	7
139	R:R:L215	R:R:P185	3.28	No	No	1	5	7
140	R:R:D186	R:R:Y205	11.49	No	Yes	1	4	3
141	R:R:F189	R:R:I188	11.3	No	No	0	5	4
142	R:R:F189	R:R:N206	3.62	No	No	0	5	4
143	R:R:F189	R:R:F207	25.72	No	Yes	0	5	4
144	R:R:C203	R:R:L190	4.76	Yes	Yes	1	9	5
145	R:R:L190	R:R:Y205	9.38	Yes	Yes	1	5	3
146	R:R:D195	R:R:H193	10.08	No	No	5	2	3
147	R:R:H193	R:R:Q204	4.95	No	No	5	3	3
148	R:R:H194	R:R:T201	6.85	No	No	0	2	5
149	R:R:D195	R:R:Q204	3.92	No	No	5	2	3
150	R:R:L198	R:R:R197	14.58	No	No	0	1	4
151	R:R:A200	R:R:H202	4.39	No	No	0	1	3
152	R:R:F207	R:R:Y205	7.22	Yes	Yes	1	4	3
153	R:R:L215	R:R:Y205	3.52	No	Yes	1	5	3
154	L:L:?1	R:R:Y205	6.62	Yes	Yes	1	0	3
155	R:R:F207	R:R:P208	4.33	Yes	No	0	4	4
156	R:R:F207	R:R:G211	6.02	Yes	No	0	4	4
157	R:R:F207	R:R:L215	10.96	Yes	No	1	4	5
158	R:R:K300	R:R:R216	3.71	No	No	0	5	3
159	L:L:?1	R:R:R216	4.12	Yes	No	0	0	3
160	L:L:?1	R:R:Q219	9.02	Yes	No	0	0	5
161	R:R:F224	R:R:L220	3.65	Yes	Yes	2	8	4
162	R:R:L220	R:R:L225	4.15	Yes	No	0	4	4
163	R:R:H272	R:R:L220	3.86	Yes	Yes	2	8	4
164	R:R:G223	R:R:P227	4.06	No	No	0	5	9
165	R:R:F224	R:R:L228	4.87	Yes	No	0	8	7
166	R:R:F224	R:R:T269	6.49	Yes	No	0	8	5
167	R:R:F224	R:R:H272	18.1	Yes	Yes	2	8	8
168	R:R:L226	R:R:P227	6.57	No	No	0	6	9
169	R:R:F264	R:R:L228	3.65	Yes	No	0	9	7
170	R:R:M231	R:R:Y235	3.59	Yes	Yes	2	8	8
171	R:R:F264	R:R:M231	8.71	Yes	Yes	2	9	8
172	R:R:H237	R:R:Y233	16.33	No	No	0	4	4
173	R:R:V257	R:R:Y235	8.83	No	Yes	0	7	8
174	R:R:V260	R:R:Y235	3.79	No	Yes	2	8	8
175	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
176	R:R:Y235	R:R:Y318	2.98	Yes	Yes	2	8	9
177	R:R:I238	R:R:L242	2.85	Yes	No	0	8	8
178	R:R:L239	R:R:V257	4.47	No	No	0	5	7
179	R:R:L242	R:R:M254	4.24	No	No	0	8	6
180	R:R:L243	R:R:M254	4.24	No	No	0	4	6
181	R:R:R250	R:R:S245	10.54	Yes	No	0	6	4
182	R:R:M254	R:R:R250	4.96	No	Yes	0	6	6
183	R:R:L256	R:R:V321	8.94	No	No	0	8	7
184	R:R:V260	R:R:Y318	7.57	No	Yes	2	8	9
185	R:R:L266	R:R:V262	2.98	No	No	0	5	5
186	R:R:F264	R:R:W268	7.02	Yes	Yes	2	9	9
187	R:R:F264	R:R:H310	4.53	Yes	Yes	2	9	9
188	R:R:C267	R:R:L306	3.17	No	No	0	9	8
189	R:R:C267	R:R:H310	8.85	No	Yes	0	9	9
190	R:R:H272	R:R:W268	3.17	Yes	Yes	2	8	9
191	R:R:G307	R:R:W268	8.44	No	Yes	0	8	9
192	R:R:H310	R:R:W268	7.41	Yes	Yes	2	9	9
193	R:R:P270	R:R:T269	3.5	No	No	0	9	5
194	R:R:P270	R:R:T303	3.5	No	No	0	9	7
195	R:R:H272	R:R:Y271	6.53	Yes	Yes	0	8	6
196	R:R:V275	R:R:Y271	8.83	No	Yes	0	5	6
197	R:R:T303	R:R:Y271	6.24	No	Yes	0	7	6
198	L:L:?1	R:R:Y271	13.91	Yes	Yes	0	0	6
199	R:R:A299	R:R:V274	3.39	No	No	0	5	4
200	R:R:D278	R:R:D282	11.98	No	No	0	5	2
201	R:R:D278	R:R:K300	9.68	No	No	0	5	5
202	R:R:I279	R:R:L283	2.85	No	No	0	5	1
203	R:R:A285	R:R:L280	3.15	No	No	0	1	4
204	R:R:L286	R:R:M281	4.24	No	No	6	1	3
205	R:R:M281	R:R:R292	7.44	No	Yes	6	3	3
206	R:R:D282	R:R:R288	8.34	No	No	0	2	4
207	R:R:L286	R:R:R292	9.72	No	Yes	6	1	3
208	R:R:N289	R:R:R292	12.05	No	Yes	0	5	3
209	R:R:K300	R:R:V296	4.55	No	No	0	5	4
210	R:R:S304	R:R:Y308	7.63	No	No	1	5	6
211	L:L:?1	R:R:S304	5.09	Yes	No	1	0	5
212	R:R:L306	R:R:M309	2.83	No	No	0	8	5
213	L:L:?1	R:R:Y308	6.62	Yes	No	1	0	6
214	R:R:H310	R:R:N314	7.65	Yes	No	2	9	9
215	R:R:F320	R:R:P315	2.89	No	No	0	7	9
216	R:R:A319	R:R:F325	6.93	No	Yes	4	7	8
217	R:R:F320	R:R:F325	10.72	No	Yes	0	7	8
218	R:R:F320	R:R:M329	3.73	No	Yes	0	7	6
219	R:R:R326	R:R:V323	5.23	No	No	0	8	5
220	R:R:E327	R:R:V323	4.28	No	No	0	5	5
221	R:R:K324	R:R:R328	4.95	No	No	0	6	5
222	R:R:M329	R:R:W330	4.65	Yes	No	0	6	2
223	R:R:L333	R:R:M329	4.24	No	Yes	0	6	6
224	R:R:D46	R:R:L49	2.71	No	No	0	4	3
225	R:R:C179	R:R:Y136	2.69	No	Yes	0	8	6
226	R:R:D297	R:R:D52	2.66	No	No	0	4	5
227	R:R:F51	R:R:V298	2.62	Yes	No	0	5	2
228	R:R:F51	R:R:V302	2.62	Yes	No	0	5	6
229	R:R:R53	R:R:V115	2.62	No	No	0	3	4
230	R:R:F119	R:R:V111	2.62	Yes	No	0	7	4
231	R:R:H194	R:R:N199	2.55	No	No	0	2	5
232	R:R:I279	R:R:R216	2.51	No	No	0	5	3
233	R:R:M331	R:R:R328	2.48	No	No	0	4	5
234	R:R:F64	R:R:L65	2.44	Yes	No	0	7	5
235	R:R:L251	R:R:R250	2.43	No	Yes	0	5	6
236	R:R:I238	R:R:Y150	2.42	Yes	Yes	0	8	8
237	R:R:I238	R:R:Y235	2.42	Yes	Yes	0	8	8
238	R:R:I133	R:R:W176	2.35	Yes	No	0	6	9
239	R:R:Q209	R:R:R212	2.34	No	No	0	2	4
240	R:R:F182	R:R:Y136	2.06	Yes	Yes	0	5	6
241	R:R:G70	R:R:P315	2.03	No	No	0	7	9
242	R:R:C312	R:R:G67	1.96	No	No	0	8	8
243	R:R:C290	R:R:G291	1.96	No	No	0	8	2
244	R:R:A73	R:R:G70	1.95	No	No	0	7	7
245	R:R:A75	R:R:G72	1.95	No	No	0	7	4
246	R:R:A137	R:R:G138	1.95	No	No	0	7	9
247	R:R:A139	R:R:G223	1.95	No	No	0	8	5
248	R:R:P164	R:R:P165	1.95	No	No	0	6	2
249	R:R:A214	R:R:G211	1.95	No	No	0	3	4
250	R:R:A143	R:R:P227	1.87	No	No	0	7	9
251	R:R:G305	R:R:S304	1.86	No	No	0	5	5
252	R:R:G67	R:R:V103	1.84	No	No	0	8	6
253	R:R:A75	R:R:A96	1.79	No	No	0	7	9
254	R:R:A137	R:R:A98	1.79	No	No	0	7	8
255	R:R:A166	R:R:S87	1.71	No	No	0	4	6
256	R:R:A192	R:R:S121	1.71	No	No	0	5	3
257	R:R:C144	R:R:V175	1.71	No	No	0	7	7
258	R:R:C179	R:R:V175	1.71	No	No	0	8	7
259	R:R:G177	R:R:L180	1.71	No	No	0	4	4
260	R:R:C234	R:R:V230	1.71	No	No	0	7	7
261	R:R:A114	R:R:V115	1.7	No	No	0	5	4
262	R:R:G291	R:R:N289	1.7	No	No	0	2	5
263	R:R:A192	R:R:T201	1.68	No	No	0	5	5
264	R:R:A265	R:R:T269	1.68	No	No	0	5	5
265	R:R:L56	R:R:P57	1.64	Yes	No	0	5	4
266	R:R:L184	R:R:P185	1.64	No	No	0	4	7
267	R:R:S121	R:R:S191	1.63	No	No	0	3	4
268	R:R:V217	R:R:V221	1.6	No	No	0	4	5
269	R:R:V258	R:R:V262	1.6	No	No	0	5	5
270	R:R:T213	R:R:V217	1.59	No	No	0	1	4
271	R:R:T303	R:R:V274	1.59	No	No	0	7	4
272	R:R:A200	R:R:L198	1.58	No	No	0	1	1
273	R:R:A222	R:R:L218	1.58	No	No	0	5	3
274	R:R:A253	R:R:L242	1.58	No	No	0	7	8
275	R:R:A263	R:R:L317	1.58	No	No	0	6	8
276	R:R:I279	R:R:V217	1.54	No	No	0	5	4
277	R:R:M281	R:R:V296	1.52	No	No	0	3	4
278	R:R:G247	R:R:R250	1.5	No	Yes	0	3	6
279	R:R:L93	R:R:V97	1.49	No	No	0	6	6
280	R:R:L101	R:R:V97	1.49	No	No	0	5	6
281	R:R:L239	R:R:V258	1.49	No	No	0	5	5
282	R:R:L243	R:R:V244	1.49	No	No	0	4	4
283	R:R:L317	R:R:V259	1.49	No	No	0	8	5
284	R:R:L317	R:R:V260	1.49	No	No	0	8	8
285	R:R:L273	R:R:V277	1.49	No	No	0	6	5
286	R:R:L173	R:R:T169	1.47	No	No	0	5	4
287	R:R:K125	R:R:L190	1.41	No	Yes	0	7	5
288	R:R:L68	R:R:L69	1.38	No	No	0	6	5
289	R:R:L220	R:R:L276	1.38	Yes	No	0	4	5
290	R:R:L276	R:R:L280	1.38	No	No	0	5	4
291	R:R:L280	R:R:L286	1.38	No	No	0	4	1
292	R:R:A287	R:R:R292	1.38	No	Yes	0	1	3
293	R:R:L159	R:R:Q158	1.33	No	No	0	6	4
294	R:R:R335	R:R:S80	1.32	No	No	0	4	5
295	R:R:F47	R:R:V298	1.31	No	No	0	1	2
296	R:R:F187	R:R:I133	1.26	No	Yes	0	4	6
297	R:R:D195	R:R:H202	1.26	No	No	0	2	3
298	R:R:F64	R:R:L104	1.22	Yes	No	0	7	5
299	R:R:F119	R:R:L108	1.22	Yes	No	0	7	6
300	R:R:F182	R:R:L181	1.22	Yes	No	0	5	5
301	R:R:E293	R:R:R197	1.16	No	No	0	1	4
302	R:R:R252	R:R:R326	1.07	No	No	0	7	8
303	R:R:R162	R:R:Y160	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F51	4.885	4	0	5
2	R:R:L56	4.046	5	1	5
3	R:R:Y60	5.42	4	1	8
4	R:R:F64	6.1825	4	0	7
5	R:R:V74	4.384	5	4	9
6	R:R:L78	3.5125	4	4	7
7	R:R:F91	5.435	6	2	7
8	R:R:L95	6.1775	4	2	9
9	R:R:D99	7.965	4	2	9
10	R:R:W109	8.14429	7	1	5
11	R:R:W117	8.05167	6	1	9
12	R:R:F119	6.738	5	0	7
13	R:R:F131	8.406	5	1	5
14	R:R:I133	2.4275	4	0	6
15	R:R:Y136	5.142	5	0	6
16	R:R:D148	5.13	4	0	8
17	R:R:Y150	5.39286	7	3	8
18	R:R:V168	6.61	4	2	8
19	R:R:F182	3.865	4	0	5
20	R:R:L190	5.0775	4	1	5
21	R:R:C203	5.295	4	1	9
22	R:R:Y205	6.95333	6	1	3
23	R:R:F207	9.52333	6	1	4
24	R:R:L220	3.26	4	2	4
25	R:R:F224	8.2775	4	2	8
26	R:R:M231	6.405	4	2	8
27	R:R:Y235	5.535	8	2	8
28	R:R:I238	3.395	4	0	8
29	R:R:R250	4.8575	4	0	6
30	R:R:F264	5.9775	4	2	9
31	R:R:W268	6.41	5	2	9
32	R:R:Y271	8.8775	4	0	6
33	R:R:H272	7.915	4	2	8
34	R:R:R292	7.6475	4	6	3
35	R:R:H310	7.11	4	2	9
36	R:R:Y318	6.164	5	2	9
37	R:R:F325	8.675	4	4	8
38	R:R:M329	3.915	4	0	6
39	L:L:?1	8.83833	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D297	R:R:S48	16.5255	2.94	No	No	0	4	4
2	R:R:D297	R:R:D52	19.2974	2.66	No	No	0	4	5
3	R:R:D52	R:R:F51	25.2936	3.58	No	Yes	0	5	5
4	R:R:F51	R:R:F55	37.0645	10.72	Yes	No	0	5	4
5	R:R:F55	R:R:L56	38.3638	4.87	No	Yes	0	4	5
6	R:R:L59	R:R:Y60	29.769	5.86	No	Yes	0	6	8
7	L:L:?1	R:R:L56	42.8778	3.13	Yes	Yes	1	0	5
8	R:R:L59	R:R:L63	29.0183	4.15	No	No	0	6	7
9	R:R:L63	R:R:M309	14.3503	2.83	No	No	0	7	5
10	R:R:C312	R:R:L63	34.7161	3.17	No	No	0	8	7
11	R:R:C312	R:R:G67	28.5756	1.96	No	No	0	8	8
12	R:R:G67	R:R:V103	25.4764	1.84	No	No	0	8	6
13	R:R:L68	R:R:V103	19.2204	2.98	No	No	0	6	6
14	R:R:F64	R:R:L68	12.8874	10.96	Yes	No	0	7	6
15	L:L:?1	R:R:F131	50.8373	9.63	Yes	Yes	1	0	5
16	R:R:F131	R:R:L102	37.2859	12.18	Yes	No	0	5	6
17	R:R:C311	R:R:L102	37.3436	3.17	No	No	0	8	6
18	R:R:C311	R:R:D99	37.8056	6.22	No	Yes	0	8	9
19	R:R:D99	R:R:N71	87.5361	6.73	Yes	No	0	9	9
20	R:R:N71	R:R:P315	82.2425	9.77	No	No	0	9	9
21	L:L:?1	R:R:W109	90.8277	27.67	Yes	Yes	1	0	5
22	R:R:T105	R:R:W109	37.4783	4.85	No	Yes	1	7	5
23	R:R:L130	R:R:T105	63.6477	2.95	No	No	1	5	7
24	R:R:L101	R:R:L130	54.7642	2.77	No	No	1	5	5
25	R:R:L101	R:R:V97	50.8566	1.49	No	No	0	5	6
26	R:R:L93	R:R:V97	46.6217	1.49	No	No	0	6	6
27	R:R:L78	R:R:L93	42.0982	4.15	Yes	No	0	7	6
28	R:R:F131	R:R:T105	30.5197	3.89	Yes	No	1	5	7
29	R:R:L78	R:R:V74	31.3186	2.98	Yes	Yes	4	7	9
30	R:R:A96	R:R:V74	13.0991	3.39	No	Yes	0	9	9
31	R:R:F320	R:R:F325	48.4216	10.72	No	Yes	0	7	8
32	R:R:F320	R:R:P315	74.2445	2.89	No	No	0	7	9
33	R:R:F325	R:R:V77	17.7382	7.87	Yes	No	0	8	7
34	R:R:F320	R:R:M329	24.4658	3.73	No	Yes	0	7	6
35	R:R:M329	R:R:V77	15.9095	3.04	Yes	No	0	6	7
36	R:R:L332	R:R:V77	26.102	2.98	No	No	0	5	7
37	R:R:L78	R:R:L85	33.2724	2.77	Yes	No	0	7	6
38	R:R:L332	R:R:S80	19.923	6.01	No	No	0	5	5
39	R:R:L85	R:R:R81	21.078	7.29	No	No	0	6	5
40	R:R:R328	R:R:R81	12.5602	18.13	No	No	0	5	5
41	R:R:R335	R:R:S80	13.2916	1.32	No	No	0	4	5
42	R:R:P165	R:R:R167	18.691	11.53	No	No	0	2	4
43	R:R:P164	R:R:P165	28.6718	1.95	No	No	0	6	2
44	R:R:P164	R:R:R161	48.5756	14.41	No	No	0	6	4
45	R:R:A166	R:R:R161	57.18	4.15	No	No	0	4	4
46	R:R:A166	R:R:S87	67.0837	1.71	No	No	0	4	6
47	R:R:D148	R:R:S87	38.4986	7.36	Yes	No	0	8	6
48	R:R:D148	R:R:F91	51.9153	4.78	Yes	Yes	0	8	7
49	R:R:C144	R:R:F91	63.5322	5.59	No	Yes	0	7	7
50	R:R:C144	R:R:V175	64.4081	1.71	No	No	0	7	7
51	R:R:C179	R:R:V175	67.6805	1.71	No	No	0	8	7
52	R:R:C179	R:R:Y136	70.2214	2.69	No	Yes	0	8	6
53	R:R:F135	R:R:Y136	47.3051	7.22	No	Yes	0	7	6
54	L:L:?1	R:R:F135	94.514	8.95	Yes	No	0	0	7
55	R:R:S87	R:R:V168	38.5467	4.85	No	Yes	0	6	8
56	R:R:F91	R:R:V168	48.2098	10.49	Yes	Yes	2	7	8
57	R:R:Q219	R:R:Y136	37.0067	6.76	No	Yes	0	5	6
58	L:L:?1	R:R:Q219	38.1328	9.02	Yes	No	0	0	5
59	R:R:F91	R:R:I145	59.3648	3.77	Yes	No	2	7	9
60	R:R:F135	R:R:W268	69.3551	6.01	No	Yes	0	7	9
61	R:R:F264	R:R:W268	65.6882	7.02	Yes	Yes	2	9	9
62	R:R:F264	R:R:M231	90.6352	8.71	Yes	Yes	2	9	8
63	R:R:L142	R:R:M231	30.308	5.65	No	Yes	0	8	8
64	R:R:L142	R:R:Y318	43.0414	7.03	No	Yes	0	8	9
65	R:R:I145	R:R:Y318	41.5784	6.04	No	Yes	2	9	9
66	R:R:M231	R:R:Y235	97.2955	3.59	Yes	Yes	2	8	8
67	R:R:Y235	R:R:Y318	40.6641	2.98	Yes	Yes	2	8	9
68	R:R:R149	R:R:Y235	22.2137	6.17	No	Yes	2	9	8
69	R:R:I145	R:R:R149	21.001	6.26	No	No	2	9	9
70	R:R:C172	R:R:F91	27.719	2.79	No	Yes	0	7	7
71	R:R:D99	R:R:L95	69.461	8.14	Yes	Yes	2	9	9
72	R:R:L141	R:R:L95	48.7007	5.54	No	Yes	0	8	9
73	R:R:H94	R:R:L141	45.8903	3.86	No	No	0	9	8
74	R:R:H310	R:R:W268	23.6862	7.41	Yes	Yes	2	9	9
75	R:R:H310	R:R:N314	31.7806	7.65	Yes	No	2	9	9
76	R:R:L95	R:R:N314	16.3426	5.49	Yes	No	2	9	9
77	R:R:H94	R:R:W176	42.4928	6.35	No	No	0	9	9
78	R:R:W109	R:R:W117	73.8691	6.56	Yes	Yes	1	5	9
79	R:R:D112	R:R:W117	29.2782	10.05	No	Yes	0	5	9
80	R:R:D112	R:R:H202	26.0443	16.39	No	No	0	5	3
81	R:R:F119	R:R:W117	48.3253	21.05	Yes	Yes	0	7	9
82	R:R:F119	R:R:V118	35.7363	3.93	Yes	No	0	7	3
83	R:R:Q116	R:R:V118	32.5409	4.3	No	No	0	3	3
84	R:R:Q116	R:R:T201	20.0289	4.25	No	No	0	3	5
85	R:R:L190	R:R:Y205	14.2156	9.38	Yes	Yes	1	5	3
86	L:L:?1	R:R:Y205	39.3167	6.62	Yes	Yes	1	0	3
87	R:R:I133	R:R:W176	25.4764	2.35	Yes	No	0	6	9
88	R:R:A137	R:R:W176	13.128	5.19	No	No	0	7	9
89	R:R:A143	R:R:V230	19.1915	3.39	No	No	0	7	7
90	R:R:C234	R:R:V230	22.974	1.71	No	No	0	7	7
91	R:R:C234	R:R:Y150	26.4678	5.38	No	Yes	3	7	8
92	R:R:I238	R:R:Y150	62.82	2.42	Yes	Yes	0	8	8
93	R:R:I238	R:R:Y235	100	2.42	Yes	Yes	0	8	8
94	R:R:L151	R:R:Y150	11.4533	3.52	No	Yes	3	5	8
95	R:R:G163	R:R:P164	10.0096	4.06	No	No	0	6	6
96	R:R:F182	R:R:Y136	20.4909	2.06	Yes	Yes	0	5	6
97	R:R:F207	R:R:Y205	31.0876	7.22	Yes	Yes	1	4	3
98	R:R:F189	R:R:F207	10.5582	25.72	No	Yes	0	5	4
99	R:R:D195	R:R:H202	10.0962	1.26	No	No	0	2	3
100	R:R:A200	R:R:H202	12.9163	4.39	No	No	0	1	3
101	L:L:?1	R:R:R216	48.2194	4.12	Yes	No	0	0	3
102	R:R:K300	R:R:R216	30.9625	3.71	No	No	0	5	3
103	L:L:?1	R:R:Y271	28.2579	13.91	Yes	Yes	0	0	6
104	R:R:H272	R:R:Y271	17.6901	6.53	Yes	Yes	0	8	6
105	R:R:H272	R:R:L220	23.4264	3.86	Yes	Yes	2	8	4
106	R:R:A143	R:R:P227	15.3898	1.87	No	No	0	7	9
107	R:R:F264	R:R:L228	19.4899	3.65	Yes	No	0	9	7
108	R:R:F224	R:R:L228	17.5842	4.87	Yes	No	0	8	7
109	R:R:T303	R:R:Y271	14.9856	6.24	No	Yes	0	7	6
110	R:R:V257	R:R:Y235	19.0472	8.83	No	Yes	0	7	8
111	R:R:I238	R:R:L242	33.9461	2.85	Yes	No	0	8	8
112	R:R:L239	R:R:V257	15.2647	4.47	No	No	0	5	7
113	R:R:L242	R:R:M254	26.5351	4.24	No	No	0	8	6
114	R:R:M254	R:R:R250	15.2743	4.96	No	Yes	0	6	6
115	R:R:L239	R:R:V258	11.4726	1.49	No	No	0	5	5
116	R:R:C267	R:R:L306	17.3821	3.17	No	No	0	9	8
117	R:R:L306	R:R:M309	15.1299	2.83	No	No	0	8	5
118	R:R:I279	R:R:R216	15.9673	2.51	No	No	0	5	3
119	R:R:L276	R:R:L280	20.5679	1.38	No	No	0	5	4
120	R:R:L220	R:R:L276	24.6968	1.38	Yes	No	0	4	5
121	R:R:K300	R:R:V296	19.8653	4.55	No	No	0	5	4
122	R:R:M281	R:R:V296	16.7757	1.52	No	No	0	3	4
123	R:R:M281	R:R:R292	11.7228	7.44	No	Yes	6	3	3
124	R:R:N289	R:R:R292	11.6266	12.05	No	Yes	0	5	3
125	R:R:A192	R:R:T201	10.0962	1.68	No	No	0	5	5
126	R:R:C267	R:R:H310	20.5005	8.85	No	Yes	0	9	9
127	L:L:?1	R:R:Y60	34.4562	5.96	Yes	Yes	1	0	8
128	R:R:D99	R:R:N314	15.8037	10.77	Yes	No	2	9	9
129	R:R:F325	R:R:V74	30.2695	9.18	Yes	Yes	4	8	9
130	R:R:F264	R:R:H310	13.513	4.53	Yes	Yes	2	9	9
131	R:R:L142	R:R:L95	55.6882	5.54	No	Yes	0	8	9
132	R:R:C172	R:R:H94	26.1694	10.32	No	No	0	7	9
133	R:R:H272	R:R:W268	25.4668	3.17	Yes	Yes	2	8	9
134	R:R:L280	R:R:L286	12.0982	1.38	No	No	0	4	1
135	R:R:F131	R:R:W109	13.7151	6.01	Yes	Yes	1	5	5
136	R:R:F224	R:R:L220	10.0192	3.65	Yes	Yes	2	8	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F55	R:R:L56	4.87	0	No	Yes	4	5	2	1
R:R:F55	R:R:L59	7.31	0	No	No	4	6	2	2
R:R:L56	R:R:Y60	5.86	1	Yes	Yes	5	8	1	1
R:R:A113	R:R:L56	4.73	1	No	Yes	5	5	1	1
L:L:?1	R:R:L56	3.13	1	Yes	Yes	0	5	0	1
R:R:L59	R:R:Y60	5.86	0	No	Yes	6	8	2	1
R:R:A110	R:R:Y60	4	0	No	Yes	7	8	2	1
L:L:?1	R:R:Y60	5.96	1	Yes	Yes	0	8	0	1
R:R:F131	R:R:L102	12.18	1	Yes	No	5	6	1	2
R:R:T105	R:R:W109	4.85	1	No	Yes	7	5	2	1
R:R:F131	R:R:T105	3.89	1	Yes	No	5	7	1	2
R:R:W109	R:R:W117	6.56	1	Yes	Yes	5	9	1	2
R:R:A127	R:R:W109	3.89	0	No	Yes	5	5	2	1
R:R:G128	R:R:W109	2.81	0	No	Yes	6	5	2	1
R:R:F131	R:R:W109	6.01	1	Yes	Yes	5	5	1	1
R:R:C203	R:R:W109	5.22	1	Yes	Yes	9	5	2	1
L:L:?1	R:R:W109	27.67	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:A113	5.34	1	Yes	No	0	5	0	1
R:R:C203	R:R:W117	3.92	1	Yes	Yes	9	9	2	2
R:R:F131	R:R:Y308	10.32	1	Yes	No	5	6	1	1
L:L:?1	R:R:F131	9.63	1	Yes	Yes	0	5	0	1
R:R:N132	R:R:Y136	6.98	1	No	Yes	4	6	2	2
R:R:D186	R:R:N132	13.46	1	No	No	4	4	2	2
R:R:N132	R:R:Y205	3.49	1	No	Yes	4	3	2	1
R:R:F135	R:R:Y136	7.22	0	No	Yes	7	6	1	2
R:R:F135	R:R:W268	6.01	0	No	Yes	7	9	1	2
L:L:?1	R:R:F135	8.95	1	Yes	No	0	7	0	1
R:R:Q219	R:R:Y136	6.76	0	No	Yes	5	6	1	2
R:R:D186	R:R:Y205	11.49	1	No	Yes	4	3	2	1
R:R:C203	R:R:L190	4.76	1	Yes	Yes	9	5	2	2
R:R:L190	R:R:Y205	9.38	1	Yes	Yes	5	3	2	1
R:R:F207	R:R:Y205	7.22	1	Yes	Yes	4	3	2	1
R:R:L215	R:R:Y205	3.52	1	No	Yes	5	3	2	1
L:L:?1	R:R:Y205	6.62	1	Yes	Yes	0	3	0	1
R:R:F207	R:R:L215	10.96	1	Yes	No	4	5	2	2
R:R:K300	R:R:R216	3.71	0	No	No	5	3	2	1
L:L:?1	R:R:R216	4.12	1	Yes	No	0	3	0	1
L:L:?1	R:R:Q219	9.02	1	Yes	No	0	5	0	1
R:R:H272	R:R:W268	3.17	2	Yes	Yes	8	9	2	2
R:R:H272	R:R:Y271	6.53	2	Yes	Yes	8	6	2	1
R:R:V275	R:R:Y271	8.83	0	No	Yes	5	6	2	1
R:R:T303	R:R:Y271	6.24	0	No	Yes	7	6	2	1
L:L:?1	R:R:Y271	13.91	1	Yes	Yes	0	6	0	1
R:R:S304	R:R:Y308	7.63	1	No	No	5	6	1	1
L:L:?1	R:R:S304	5.09	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y308	6.62	1	Yes	No	0	6	0	1
R:R:I279	R:R:R216	2.51	0	No	No	5	3	2	1
R:R:G305	R:R:S304	1.86	0	No	No	5	5	2	1
R:R:L56	R:R:P57	1.64	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XYK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	264
Number of Links	303
Number of Hubs	39
Number of Links mediated by Hubs	155
Number of Communities	6
Number of Nodes involved in Communities	58
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	137
Number Of Links MetaPath	136
Number of Shortest Paths	52221
Length Of Smallest Path	3
Average Path Length	11.7725
Length of Longest Path	24
Minimum Path Strength	1.38
Average Path Strength	5.94679
Maximum Path Strength	18.51
Minimum Path Correlation	0.7
Average Path Correlation	0.923756
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	50.0935
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.7386
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • protein binding • binding • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • response to stimulus • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cellular response to chemical stimulus • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • inorganic ion transmembrane transport • establishment of localization • inorganic cation transmembrane transport • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • intracellular anatomical structure • cytoplasm • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • protein localization • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8XYK_nogp_Chain_R D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	10.1038/s41594-023-01175-5
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	10.1038/s41594-023-01175-5
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	To be published
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	To be published
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	To be published
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go1/β1/γ2	3.07	2025-02-26	To be published
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	To be published
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go1/β1/γ2	3.03	2025-02-26	To be published
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	To be published
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go1/β1/γ2	3.3	2025-02-26	To be published
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	To be published

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Download 8XYK_nogp.zip

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