psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L59	R:R:Y60	5.86	No	No	0	6	8
2	R:R:G305	R:R:Y60	2.9	No	No	0	5	8
3	R:R:L62	R:R:L66	8.3	No	No	0	5	6
4	R:R:L106	R:R:L63	4.15	Yes	No	0	8	7
5	R:R:C312	R:R:L63	3.17	No	No	0	8	7
6	R:R:F64	R:R:L65	7.31	No	No	0	7	5
7	R:R:F64	R:R:L68	4.87	No	No	0	7	6
8	R:R:F64	R:R:L106	4.87	No	Yes	0	7	8
9	R:R:G67	R:R:V103	5.52	No	No	0	8	6
10	R:R:L68	R:R:V103	5.96	No	No	0	6	6
11	R:R:D99	R:R:N71	5.39	Yes	No	0	9	9
12	R:R:N71	R:R:T100	7.31	No	No	0	9	7
13	R:R:N71	R:R:P315	6.52	No	No	0	9	9
14	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
15	R:R:P315	R:R:V74	3.53	No	Yes	0	9	9
16	R:R:A319	R:R:V74	3.39	No	Yes	2	7	9
17	R:R:F325	R:R:V74	6.55	Yes	Yes	2	8	9
18	R:R:F325	R:R:V77	6.55	Yes	No	0	8	7
19	R:R:M329	R:R:V77	3.04	No	No	0	6	7
20	R:R:L78	R:R:L85	2.77	No	No	0	7	6
21	R:R:L78	R:R:L92	2.77	No	No	0	7	8
22	R:R:L79	R:R:L93	4.15	No	No	0	4	6
23	R:R:L332	R:R:S80	4.5	No	No	0	5	5
24	R:R:R81	R:R:T83	7.76	No	No	0	5	6
25	R:R:L85	R:R:R81	3.64	No	No	0	6	5
26	R:R:R328	R:R:R81	9.6	No	No	0	5	5
27	R:R:D89	R:R:L85	8.14	No	No	0	8	6
28	R:R:D89	R:R:S86	5.89	No	No	0	8	7
29	R:R:D148	R:R:S87	5.89	No	No	0	8	6
30	R:R:D89	R:R:T88	2.89	No	No	0	8	8
31	R:R:D148	R:R:T88	4.34	No	No	0	8	8
32	R:R:T90	R:R:V168	3.17	No	No	0	6	8
33	R:R:C144	R:R:F91	6.98	No	Yes	0	7	7
34	R:R:F91	R:R:I145	3.77	Yes	No	0	7	9
35	R:R:F91	R:R:V168	10.49	Yes	No	0	7	8
36	R:R:C172	R:R:F91	4.19	No	Yes	0	7	7
37	R:R:A319	R:R:L92	3.15	No	No	0	7	8
38	R:R:H94	R:R:L141	3.86	No	No	0	9	8
39	R:R:C172	R:R:H94	11.79	No	No	0	7	9
40	R:R:H94	R:R:W176	7.41	No	No	0	9	9
41	R:R:D99	R:R:L95	5.43	Yes	Yes	1	9	9
42	R:R:L141	R:R:L95	5.54	No	Yes	0	8	9
43	R:R:L142	R:R:L95	6.92	No	Yes	0	8	9
44	R:R:L95	R:R:N314	10.98	Yes	No	1	9	9
45	R:R:L101	R:R:V97	2.98	No	No	0	5	6
46	R:R:C311	R:R:D99	7.78	No	Yes	0	8	9
47	R:R:D99	R:R:N314	9.42	Yes	No	1	9	9
48	R:R:L101	R:R:N134	9.61	No	No	0	5	8
49	R:R:F131	R:R:L102	8.53	Yes	Yes	3	5	6
50	R:R:L102	R:R:N134	9.61	Yes	No	0	6	8
51	R:R:L102	R:R:Y308	5.86	Yes	Yes	3	6	6
52	R:R:C311	R:R:L102	3.17	No	Yes	0	8	6
53	R:R:T105	R:R:Y308	4.99	No	Yes	0	7	6
54	R:R:L106	R:R:P107	4.93	Yes	No	0	8	9
55	R:R:L106	R:R:Y308	7.03	Yes	Yes	0	8	6
56	R:R:L108	R:R:P107	3.28	No	No	0	6	9
57	R:R:F187	R:R:V126	6.55	No	No	0	4	5
58	R:R:A129	R:R:D186	4.63	No	No	0	5	4
59	R:R:A129	R:R:F187	8.32	No	No	0	5	4
60	R:R:F131	R:R:Y308	8.25	Yes	Yes	3	5	6
61	R:R:F182	R:R:N132	4.83	Yes	No	0	5	4
62	R:R:D186	R:R:N132	10.77	No	No	0	4	4
63	R:R:C179	R:R:I133	6.55	No	Yes	0	8	6
64	R:R:A183	R:R:I133	3.25	No	Yes	0	7	6
65	R:R:F135	R:R:W268	25.05	No	Yes	1	7	9
66	R:R:F135	R:R:Y271	3.09	No	Yes	1	7	6
67	R:R:F135	R:R:H272	5.66	No	Yes	1	7	8
68	R:R:F182	R:R:Y136	12.38	Yes	No	0	5	6
69	R:R:Q219	R:R:Y136	15.78	No	No	0	5	6
70	R:R:G223	R:R:Y136	2.9	No	No	0	5	6
71	R:R:A139	R:R:P227	3.74	No	Yes	0	8	9
72	R:R:A139	R:R:W268	3.89	No	Yes	0	8	9
73	R:R:L140	R:R:V175	10.43	No	No	0	6	7
74	R:R:L140	R:R:L178	2.77	No	No	0	6	4
75	R:R:L141	R:R:V175	2.98	No	No	0	8	7
76	R:R:L142	R:R:M231	5.65	No	No	0	8	8
77	R:R:L142	R:R:Y318	14.07	No	No	0	8	9
78	R:R:I145	R:R:R149	6.26	No	No	0	9	9
79	R:R:M231	R:R:S146	6.13	No	No	0	8	9
80	R:R:S146	R:R:Y235	8.9	No	Yes	0	9	8
81	R:R:F147	R:R:L151	7.31	No	No	0	6	5
82	R:R:R149	R:R:Y235	7.2	No	Yes	0	9	8
83	R:R:R149	R:R:Y318	4.12	No	No	0	9	9
84	R:R:L151	R:R:Y150	3.52	No	Yes	0	5	8
85	R:R:V154	R:R:Y150	15.14	No	Yes	4	7	8
86	R:R:H155	R:R:Y150	7.62	No	Yes	4	6	8
87	R:R:C234	R:R:Y150	5.38	No	Yes	0	7	8
88	R:R:H237	R:R:Y150	3.27	No	Yes	0	4	8
89	R:R:L151	R:R:L159	4.15	No	No	0	5	6
90	R:R:I153	R:R:I238	5.89	No	No	0	8	8
91	R:R:H155	R:R:V154	8.3	No	No	4	6	7
92	R:R:R167	R:R:T169	6.47	No	No	0	4	4
93	R:R:T171	R:R:V168	4.76	No	No	0	5	8
94	R:R:L173	R:R:T169	2.95	No	No	0	5	4
95	R:R:G177	R:R:L180	5.13	No	No	0	4	4
96	R:R:F182	R:R:L215	8.53	Yes	No	0	5	5
97	R:R:F182	R:R:L218	9.74	Yes	No	0	5	3
98	R:R:L215	R:R:P185	9.85	No	No	0	5	7
99	R:R:G211	R:R:P208	4.06	No	No	0	4	4
100	R:R:D278	R:R:R216	7.15	No	No	5	5	3
101	R:R:I279	R:R:R216	3.76	No	No	0	5	3
102	R:R:D282	R:R:R216	4.76	Yes	No	5	2	3
103	R:R:Q219	R:R:Y271	7.89	No	Yes	0	5	6
104	R:R:L220	R:R:L225	2.77	No	No	0	4	4
105	R:R:H272	R:R:L220	3.86	Yes	No	0	8	4
106	R:R:L220	R:R:L276	4.15	No	No	0	4	5
107	R:R:G223	R:R:P227	4.06	No	Yes	0	5	9
108	R:R:F224	R:R:W268	7.02	No	Yes	1	8	9
109	R:R:F224	R:R:T269	6.49	No	No	0	8	5
110	R:R:F224	R:R:H272	26.02	No	Yes	1	8	8
111	R:R:L226	R:R:P227	6.57	No	Yes	0	6	9
112	R:R:L226	R:R:V230	2.98	No	No	0	6	7
113	R:R:F264	R:R:L228	4.87	Yes	No	0	9	7
114	R:R:F264	R:R:M231	8.71	Yes	No	0	9	8
115	R:R:H237	R:R:Y233	16.33	No	No	0	4	4
116	R:R:V257	R:R:Y235	11.36	No	Yes	0	7	8
117	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
118	R:R:I238	R:R:L242	2.85	No	Yes	0	8	8
119	R:R:L239	R:R:V257	4.47	No	No	0	5	7
120	R:R:L242	R:R:S245	3	Yes	No	0	8	4
121	R:R:L242	R:R:M254	4.24	Yes	No	0	8	6
122	R:R:L243	R:R:M254	7.07	No	No	0	4	6
123	R:R:R250	R:R:S245	10.54	Yes	No	0	6	4
124	R:R:L251	R:R:R250	3.64	No	Yes	0	5	6
125	R:R:M254	R:R:R250	3.72	No	Yes	0	6	6
126	R:R:R252	R:R:V321	3.92	No	No	0	7	7
127	R:R:L256	R:R:V321	4.47	No	No	0	8	7
128	R:R:L317	R:R:V260	2.98	No	No	0	8	8
129	R:R:V260	R:R:Y318	6.31	No	No	0	8	9
130	R:R:L266	R:R:V262	2.98	No	No	0	5	5
131	R:R:F264	R:R:W268	16.04	Yes	Yes	1	9	9
132	R:R:F264	R:R:H310	5.66	Yes	Yes	1	9	9
133	R:R:C267	R:R:H310	4.42	No	Yes	0	9	9
134	R:R:H272	R:R:W268	4.23	Yes	Yes	1	8	9
135	R:R:H310	R:R:W268	10.58	Yes	Yes	1	9	9
136	R:R:P270	R:R:T269	3.5	No	No	0	9	5
137	R:R:P270	R:R:T303	3.5	No	No	0	9	7
138	R:R:L306	R:R:P270	4.93	No	No	0	8	9
139	R:R:H272	R:R:Y271	13.07	Yes	Yes	1	8	6
140	R:R:V275	R:R:Y271	7.57	No	Yes	1	5	6
141	R:R:K300	R:R:Y271	7.17	No	Yes	1	5	6
142	R:R:T303	R:R:Y271	8.74	No	Yes	0	7	6
143	R:R:A299	R:R:V274	3.39	No	No	0	5	4
144	R:R:I279	R:R:V275	3.07	No	No	0	5	5
145	R:R:K300	R:R:V275	3.04	No	No	1	5	5
146	R:R:L276	R:R:L280	6.92	No	No	0	5	4
147	R:R:D278	R:R:D282	11.98	No	Yes	5	5	2
148	R:R:I279	R:R:L283	2.85	No	No	0	5	1
149	R:R:L286	R:R:M281	5.65	No	Yes	0	1	3
150	R:R:M281	R:R:R292	7.44	Yes	Yes	0	3	3
151	R:R:D282	R:R:R288	8.34	Yes	No	0	2	4
152	R:R:N289	R:R:R292	12.05	No	Yes	0	5	3
153	R:R:R292	R:R:R295	3.2	Yes	No	0	3	3
154	R:R:L306	R:R:M309	2.83	No	No	0	8	5
155	R:R:L313	R:R:M309	2.83	No	No	0	6	5
156	R:R:H310	R:R:N314	8.93	Yes	No	1	9	9
157	R:R:F320	R:R:P315	2.89	No	No	0	7	9
158	R:R:A319	R:R:F325	8.32	No	Yes	2	7	8
159	R:R:F320	R:R:F325	3.22	No	Yes	0	7	8
160	R:R:R326	R:R:V323	9.15	No	No	0	8	5
161	R:R:K324	R:R:R328	7.43	No	No	0	6	5
162	R:R:M329	R:R:W330	4.65	No	No	0	6	2
163	R:R:L130	R:R:N134	2.75	No	No	0	5	8
164	R:R:F131	R:R:S304	2.64	Yes	No	0	5	5
165	R:R:A98	R:R:W176	2.59	No	No	0	8	9
166	R:R:I238	R:R:Y235	2.42	No	Yes	0	8	8
167	R:R:I133	R:R:W176	2.35	Yes	No	0	6	9
168	R:R:L106	R:R:Y60	2.34	Yes	No	0	8	8
169	R:R:F131	R:R:W109	2	Yes	No	0	5	5
170	R:R:C290	R:R:G291	1.96	No	No	0	8	2
171	R:R:A75	R:R:G72	1.95	No	No	0	7	4
172	R:R:A127	R:R:G128	1.95	No	No	0	5	6
173	R:R:A84	R:R:P165	1.87	No	No	0	7	2
174	R:R:A143	R:R:P227	1.87	No	Yes	0	7	9
175	R:R:G291	R:R:S294	1.86	No	No	0	2	3
176	R:R:A137	R:R:C179	1.81	No	No	0	7	8
177	R:R:A75	R:R:A96	1.79	No	No	0	7	9
178	R:R:C234	R:R:S146	1.72	No	No	0	7	9
179	R:R:G70	R:R:L69	1.71	No	No	0	7	5
180	R:R:A166	R:R:S87	1.71	No	No	0	4	6
181	R:R:G138	R:R:L95	1.71	No	Yes	0	9	9
182	R:R:A222	R:R:V221	1.7	No	No	0	5	5
183	R:R:G291	R:R:N289	1.7	No	No	0	2	5
184	R:R:A265	R:R:T269	1.68	No	No	0	5	5
185	R:R:L184	R:R:P185	1.64	No	No	0	4	7
186	R:R:A73	R:R:M329	1.61	No	No	0	7	6
187	R:R:V154	R:R:V241	1.6	No	No	0	7	5
188	R:R:V217	R:R:V221	1.6	No	No	0	4	5
189	R:R:V258	R:R:V262	1.6	No	No	0	5	5
190	R:R:V274	R:R:V296	1.6	No	No	0	4	4
191	R:R:C312	R:R:L66	1.59	No	No	0	8	6
192	R:R:G307	R:R:H310	1.59	No	Yes	0	8	9
193	R:R:A75	R:R:L79	1.58	No	No	0	7	4
194	R:R:A110	R:R:L106	1.58	No	Yes	0	7	8
195	R:R:A127	R:R:L108	1.58	No	No	0	5	6
196	R:R:A222	R:R:L218	1.58	No	No	0	5	3
197	R:R:A253	R:R:L242	1.58	No	Yes	0	7	8
198	R:R:A263	R:R:L317	1.58	No	No	0	6	8
199	R:R:A285	R:R:L280	1.58	No	No	0	1	4
200	R:R:M281	R:R:V277	1.52	Yes	No	0	3	5
201	R:R:G247	R:R:R250	1.5	No	Yes	0	3	6
202	R:R:G322	R:R:R326	1.5	No	No	0	8	8
203	R:R:L239	R:R:V258	1.49	No	No	0	5	5
204	R:R:L256	R:R:V260	1.49	No	No	0	8	8
205	R:R:L317	R:R:V259	1.49	No	No	0	8	5
206	R:R:L273	R:R:V277	1.49	No	No	0	6	5
207	R:R:I133	R:R:L180	1.43	Yes	No	0	6	4
208	R:R:I188	R:R:L184	1.43	No	No	0	4	4
209	R:R:E327	R:R:V323	1.43	No	No	0	5	5
210	R:R:I153	R:R:N152	1.42	No	No	0	8	8
211	R:R:Q209	R:R:T213	1.42	No	No	0	2	1
212	R:R:D282	R:R:M281	1.39	Yes	Yes	0	2	3
213	R:R:A166	R:R:R161	1.38	No	No	0	4	4
214	R:R:A287	R:R:R292	1.38	No	Yes	0	1	3
215	R:R:R292	R:R:V296	1.31	Yes	No	0	3	4
216	R:R:R82	R:R:T83	1.29	No	No	0	5	6
217	R:R:M331	R:R:R328	1.24	No	No	0	4	5
218	R:R:F320	R:R:L316	1.22	No	No	0	7	6
219	R:R:R252	R:R:R326	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V74	4.215	4	2	9
2	R:R:F91	6.3575	4	0	7
3	R:R:L95	6.116	5	1	9
4	R:R:D99	7.005	4	1	9
5	R:R:L102	6.7925	4	3	6
6	R:R:L106	4.15	6	0	8
7	R:R:F131	5.355	4	3	5
8	R:R:I133	3.395	4	0	6
9	R:R:Y150	6.986	5	4	8
10	R:R:F182	8.87	4	0	5
11	R:R:P227	4.06	4	0	9
12	R:R:Y235	6.986	5	0	8
13	R:R:L242	2.9175	4	0	8
14	R:R:R250	4.85	4	0	6
15	R:R:F264	8.82	4	1	9
16	R:R:W268	11.135	6	1	9
17	R:R:Y271	7.92167	6	1	6
18	R:R:H272	10.568	5	1	8
19	R:R:M281	4	4	0	3
20	R:R:D282	6.6175	4	5	2
21	R:R:R292	5.076	5	0	3
22	R:R:Y308	6.5325	4	3	6
23	R:R:H310	6.236	5	1	9
24	R:R:F325	6.16	4	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L106	R:R:L63	10.1453	4.15	Yes	No	0	8	7
2	R:R:F64	R:R:L106	12.638	4.87	No	Yes	0	7	8
3	R:R:C311	R:R:D99	66.9426	7.78	No	Yes	0	8	9
4	R:R:C311	R:R:L102	64.8915	3.17	No	Yes	0	8	6
5	R:R:L102	R:R:Y308	47.2682	5.86	Yes	Yes	3	6	6
6	R:R:L106	R:R:Y308	43.3683	7.03	Yes	Yes	0	8	6
7	R:R:D99	R:R:N71	83.3885	5.39	Yes	No	0	9	9
8	R:R:N71	R:R:P315	79.599	6.52	No	No	0	9	9
9	R:R:A96	R:R:V74	12.5	3.39	No	Yes	0	9	9
10	R:R:P315	R:R:V74	62.0125	3.53	No	Yes	0	9	9
11	R:R:A319	R:R:V74	38.3002	3.39	No	Yes	2	7	9
12	R:R:F325	R:R:V74	11.3962	6.55	Yes	Yes	2	8	9
13	R:R:F320	R:R:F325	11.7734	3.22	No	Yes	0	7	8
14	R:R:F320	R:R:P315	15.8756	2.89	No	No	0	7	9
15	R:R:F325	R:R:V77	18.9753	6.55	Yes	No	0	8	7
16	R:R:M329	R:R:V77	14.2568	3.04	No	No	0	6	7
17	R:R:A319	R:R:L92	37.1321	3.15	No	No	0	7	8
18	R:R:L78	R:R:L92	34.8786	2.77	No	No	0	7	8
19	R:R:L78	R:R:L85	32.8458	2.77	No	No	0	7	6
20	R:R:A75	R:R:A96	10.035	1.79	No	No	0	7	9
21	R:R:L85	R:R:R81	14.7811	3.64	No	No	0	6	5
22	R:R:D89	R:R:L85	16.7311	8.14	No	No	0	8	6
23	R:R:D89	R:R:T88	11.8929	2.89	No	No	0	8	8
24	R:R:D99	R:R:L95	55.7855	5.43	Yes	Yes	1	9	9
25	R:R:L141	R:R:L95	38.1347	5.54	No	Yes	0	8	9
26	R:R:H94	R:R:L141	29.0839	3.86	No	No	0	9	8
27	R:R:C172	R:R:H94	13.1898	11.79	No	No	0	7	9
28	R:R:C172	R:R:F91	11.7366	4.19	No	Yes	0	7	7
29	R:R:F91	R:R:V168	13.5394	10.49	Yes	No	0	7	8
30	R:R:I145	R:R:R149	18.5614	6.26	No	No	0	9	9
31	R:R:R149	R:R:Y318	27.741	4.12	No	No	0	9	9
32	R:R:L142	R:R:Y318	47.6269	14.07	No	No	0	8	9
33	R:R:L142	R:R:L95	49.8712	6.92	No	Yes	0	8	9
34	R:R:H94	R:R:W176	18.4419	7.41	No	No	0	9	9
35	R:R:D99	R:R:N314	75.6071	9.42	Yes	No	1	9	9
36	R:R:L102	R:R:N134	10.1453	9.61	Yes	No	0	6	8
37	R:R:L106	R:R:P107	10.1453	4.93	Yes	No	0	8	9
38	R:R:A129	R:R:D186	14.5327	4.63	No	No	0	5	4
39	R:R:D186	R:R:N132	19.3433	10.77	No	No	0	4	4
40	R:R:F182	R:R:N132	24.1354	4.83	Yes	No	0	5	4
41	R:R:F182	R:R:Y136	65.7561	12.38	Yes	No	0	5	6
42	R:R:Q219	R:R:Y136	49.5953	15.78	No	No	0	5	6
43	R:R:Q219	R:R:Y271	52.3915	7.89	No	Yes	0	5	6
44	R:R:F135	R:R:Y271	58.085	3.09	No	Yes	1	7	6
45	R:R:F135	R:R:W268	59.2531	25.05	No	Yes	1	7	9
46	R:R:H310	R:R:W268	98.4363	10.58	Yes	Yes	1	9	9
47	R:R:H310	R:R:N314	100	8.93	Yes	No	1	9	9
48	R:R:H272	R:R:Y271	61.3043	13.07	Yes	Yes	1	8	6
49	R:R:H272	R:R:W268	66.6759	4.23	Yes	Yes	1	8	9
50	R:R:G223	R:R:Y136	23.2432	2.9	No	No	0	5	6
51	R:R:G223	R:R:P227	24.3469	4.06	No	Yes	0	5	9
52	R:R:A139	R:R:P227	30.8959	3.74	No	Yes	0	8	9
53	R:R:A139	R:R:W268	32.7263	3.89	No	Yes	0	8	9
54	R:R:I133	R:R:W176	14.0637	2.35	Yes	No	0	6	9
55	R:R:L142	R:R:M231	47.3418	5.65	No	No	0	8	8
56	R:R:M231	R:R:S146	67.3289	6.13	No	No	0	8	9
57	R:R:S146	R:R:Y235	49.3837	8.9	No	Yes	0	9	8
58	R:R:R149	R:R:Y235	29.4794	7.2	No	Yes	0	9	8
59	R:R:C234	R:R:Y150	21.5232	5.38	No	Yes	0	7	8
60	R:R:C234	R:R:S146	23.8503	1.72	No	No	0	7	9
61	R:R:I238	R:R:Y235	40.6733	2.42	No	Yes	0	8	8
62	R:R:F182	R:R:L215	19.1869	8.53	Yes	No	0	5	5
63	R:R:F182	R:R:L218	19.1961	9.74	Yes	No	0	5	3
64	R:R:L215	R:R:P185	14.5235	9.85	No	No	0	5	7
65	R:R:I279	R:R:R216	59.6394	3.76	No	No	0	5	3
66	R:R:I279	R:R:V275	66.0044	3.07	No	No	0	5	5
67	R:R:V275	R:R:Y271	68.819	7.57	No	Yes	1	5	6
68	R:R:D282	R:R:R216	53.3481	4.76	Yes	No	5	2	3
69	R:R:F224	R:R:W268	10.4121	7.02	No	Yes	1	8	9
70	R:R:F224	R:R:T269	10.0442	6.49	No	No	0	8	5
71	R:R:V257	R:R:Y235	14.8915	11.36	No	Yes	0	7	8
72	R:R:I238	R:R:L242	32.2848	2.85	No	Yes	0	8	8
73	R:R:L239	R:R:V257	12.1873	4.47	No	No	0	5	7
74	R:R:L242	R:R:S245	12.0401	3	Yes	No	0	8	4
75	R:R:L242	R:R:M254	14.7351	4.24	Yes	No	0	8	6
76	R:R:V260	R:R:Y318	26.3337	6.31	No	No	0	8	9
77	R:R:L256	R:R:V260	17.099	1.49	No	No	0	8	8
78	R:R:L256	R:R:V321	14.6983	4.47	No	No	0	8	7
79	R:R:R252	R:R:V321	12.2976	3.92	No	No	0	7	7
80	R:R:R292	R:R:V296	10.4489	1.31	Yes	No	0	3	4
81	R:R:M281	R:R:R292	33.9588	7.44	Yes	Yes	0	3	3
82	R:R:D282	R:R:M281	47.1854	1.39	Yes	Yes	0	2	3
83	R:R:N289	R:R:R292	13.9349	12.05	No	Yes	0	5	3
84	R:R:G291	R:R:N289	10.4765	1.7	No	No	0	2	5
85	R:R:A222	R:R:L218	14.5327	1.58	No	No	0	5	3
86	R:R:F91	R:R:I145	15.4617	3.77	Yes	No	0	7	9
87	R:R:L95	R:R:N314	24.4205	10.98	Yes	No	1	9	9
88	R:R:F264	R:R:W268	65.0386	16.04	Yes	Yes	1	9	9
89	R:R:F264	R:R:M231	65.986	8.71	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XXZ_nogp

PDB Summary
PDB	8XXZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	209
Number of Links	219
Number of Hubs	24
Number of Links mediated by Hubs	95
Number of Communities	5
Number of Nodes involved in Communities	24
Number of Links involved in Communities	29

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	31459
Length Of Smallest Path	3
Average Path Length	13.2201
Length of Longest Path	28
Minimum Path Strength	1.285
Average Path Strength	6.5568
Maximum Path Strength	20.545
Minimum Path Correlation	0.7
Average Path Correlation	0.919058
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.3734
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.4045
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • protein binding • binding • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • cellular process • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • response to stimulus • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • cellular response to stimulus • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cellular response to chemical stimulus • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • transport • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • localization • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8XXZ_nogp_Chain_R L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R P A R V T L T C L A V W G L C L L F A L P D F I P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	-	SCH546738	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

there is no ligand in network 8XXZ_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.