psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C290	R:R:C43	7.28	No	No	0	8	9
2	R:R:Q45	R:R:S48	4.33	No	No	0	4	4
3	R:R:Q45	R:R:R288	3.5	No	No	5	4	4
4	R:R:E293	R:R:Q45	8.92	No	No	5	1	4
5	R:R:D46	R:R:N50	4.04	No	No	0	4	4
6	R:R:F47	R:R:S294	6.61	No	No	0	1	3
7	R:R:S294	R:R:S48	4.89	No	No	0	3	4
8	R:R:L49	R:R:R53	10.93	No	No	0	3	3
9	R:R:F51	R:R:F55	6.43	No	No	0	5	4
10	R:R:F51	R:R:V298	6.55	No	No	0	5	2
11	R:R:D52	R:R:L56	4.07	No	Yes	0	5	5
12	R:R:D297	R:R:D52	6.65	No	No	0	4	5
13	R:R:F55	R:R:L56	4.87	No	Yes	0	4	5
14	R:R:F55	R:R:L59	7.31	No	No	0	4	6
15	R:R:L56	R:R:Y60	8.21	Yes	Yes	1	5	8
16	R:R:A113	R:R:L56	3.15	No	Yes	1	5	5
17	R:R:L56	R:R:S301	4.5	Yes	No	1	5	4
18	L:L:?1	R:R:L56	5.26	Yes	Yes	1	0	5
19	R:R:L59	R:R:Y60	5.86	No	Yes	0	6	8
20	R:R:L59	R:R:L63	8.3	No	No	0	6	7
21	R:R:L106	R:R:Y60	14.07	No	Yes	1	8	8
22	R:R:A110	R:R:Y60	4	No	Yes	0	7	8
23	R:R:Y308	R:R:Y60	7.94	Yes	Yes	1	6	8
24	L:L:?1	R:R:Y60	12.63	Yes	Yes	1	0	8
25	R:R:L62	R:R:L66	4.15	No	No	0	5	6
26	R:R:C312	R:R:L63	3.17	No	No	0	8	7
27	R:R:F64	R:R:L68	10.96	No	No	0	7	6
28	R:R:F64	R:R:P107	5.78	No	No	0	7	9
29	R:R:G67	R:R:V103	3.68	No	No	0	8	6
30	R:R:C312	R:R:G67	3.92	No	No	0	8	8
31	R:R:L68	R:R:V103	2.98	No	No	0	6	6
32	R:R:L104	R:R:L68	6.92	No	No	0	5	6
33	R:R:G70	R:R:L69	3.42	No	No	0	7	5
34	R:R:D99	R:R:N71	6.73	Yes	No	0	9	9
35	R:R:N71	R:R:T100	4.39	No	No	0	9	7
36	R:R:N71	R:R:P315	8.15	No	No	0	9	9
37	R:R:L78	R:R:V74	2.98	Yes	Yes	4	7	9
38	R:R:L92	R:R:V74	2.98	No	Yes	4	8	9
39	R:R:A96	R:R:V74	3.39	No	Yes	0	9	9
40	R:R:A319	R:R:V74	3.39	No	Yes	4	7	9
41	R:R:F325	R:R:V74	6.55	Yes	Yes	4	8	9
42	R:R:F325	R:R:V77	9.18	Yes	No	0	8	7
43	R:R:M329	R:R:V77	4.56	No	No	0	6	7
44	R:R:L78	R:R:L92	4.15	Yes	No	4	7	8
45	R:R:F325	R:R:L78	6.09	Yes	Yes	4	8	7
46	R:R:L78	R:R:R328	3.64	Yes	Yes	4	7	5
47	R:R:L79	R:R:R82	3.64	No	No	0	4	5
48	R:R:R81	R:R:S80	3.95	Yes	No	0	5	5
49	R:R:L332	R:R:S80	3	No	No	0	5	5
50	R:R:A84	R:R:R81	4.15	No	Yes	0	7	5
51	R:R:M331	R:R:R81	4.96	No	Yes	0	4	5
52	R:R:D89	R:R:L85	6.79	No	No	4	8	6
53	R:R:L85	R:R:T90	2.95	No	No	0	6	6
54	R:R:L85	R:R:R328	3.64	No	Yes	4	6	5
55	R:R:D89	R:R:S86	8.83	No	No	0	8	7
56	R:R:K324	R:R:S86	3.06	No	No	0	6	7
57	R:R:D148	R:R:S87	5.89	Yes	No	2	8	6
58	R:R:R167	R:R:S87	3.95	Yes	No	2	4	6
59	R:R:S87	R:R:V168	3.23	No	No	0	6	8
60	R:R:D148	R:R:T88	8.67	Yes	No	0	8	8
61	R:R:R149	R:R:T88	3.88	Yes	No	0	9	8
62	R:R:D89	R:R:R328	8.34	No	Yes	4	8	5
63	R:R:T90	R:R:V168	4.76	No	No	0	6	8
64	R:R:C144	R:R:F91	5.59	No	Yes	3	7	7
65	R:R:F91	R:R:I145	3.77	Yes	No	3	7	9
66	R:R:F91	R:R:T171	5.19	Yes	No	3	7	5
67	R:R:C172	R:R:F91	4.19	No	Yes	0	7	7
68	R:R:H94	R:R:L141	3.86	No	No	0	9	8
69	R:R:C172	R:R:H94	14.74	No	No	0	7	9
70	R:R:H94	R:R:W176	7.41	No	No	0	9	9
71	R:R:D99	R:R:L95	5.43	Yes	No	6	9	9
72	R:R:L95	R:R:N314	6.87	No	No	6	9	9
73	R:R:C311	R:R:D99	3.11	No	Yes	0	8	9
74	R:R:D99	R:R:N314	9.42	Yes	No	6	9	9
75	R:R:L104	R:R:T100	2.95	No	No	0	5	7
76	R:R:L101	R:R:N134	6.87	No	Yes	0	5	8
77	R:R:F131	R:R:L102	6.09	Yes	No	0	5	6
78	R:R:L102	R:R:N134	6.87	No	Yes	0	6	8
79	R:R:T105	R:R:W109	4.85	No	Yes	1	7	5
80	R:R:L130	R:R:T105	4.42	No	No	0	5	7
81	R:R:F131	R:R:T105	3.89	Yes	No	1	5	7
82	R:R:L106	R:R:Y308	7.03	No	Yes	1	8	6
83	R:R:L108	R:R:W117	3.42	No	Yes	1	6	9
84	R:R:F119	R:R:L108	6.09	Yes	No	1	7	6
85	R:R:A127	R:R:W109	3.89	No	Yes	0	5	5
86	R:R:F131	R:R:W109	6.01	Yes	Yes	1	5	5
87	L:L:?1	R:R:W109	28.14	Yes	Yes	1	0	5
88	R:R:D112	R:R:W117	10.05	No	Yes	0	5	9
89	R:R:D112	R:R:H202	8.82	No	No	0	5	3
90	L:L:?1	R:R:A113	5.99	Yes	No	1	0	5
91	R:R:Q116	R:R:V118	5.73	No	No	0	3	3
92	R:R:A200	R:R:Q116	3.03	No	No	0	1	3
93	R:R:F119	R:R:W117	11.02	Yes	Yes	1	7	9
94	R:R:C124	R:R:W117	7.84	No	Yes	1	9	9
95	R:R:F119	R:R:V118	3.93	Yes	No	0	7	3
96	R:R:F119	R:R:L123	4.87	Yes	No	0	7	6
97	R:R:A192	R:R:S121	3.42	No	No	0	5	3
98	R:R:G122	R:R:K125	5.23	No	No	0	1	7
99	R:R:C124	R:R:C203	7.28	No	No	1	9	9
100	R:R:A129	R:R:F187	5.55	No	No	0	5	4
101	R:R:L130	R:R:N134	6.87	No	Yes	0	5	8
102	R:R:F131	R:R:Y308	10.32	Yes	Yes	1	5	6
103	L:L:?1	R:R:F131	16.2	Yes	Yes	1	0	5
104	R:R:D186	R:R:N132	13.46	No	No	1	4	4
105	R:R:N132	R:R:Y205	3.49	No	Yes	1	4	3
106	R:R:A183	R:R:I133	3.25	No	No	0	7	6
107	R:R:F135	R:R:Y136	5.16	No	Yes	0	7	6
108	R:R:F135	R:R:W268	8.02	No	Yes	0	7	9
109	L:L:?1	R:R:F135	4.63	Yes	No	0	0	7
110	R:R:F182	R:R:Y136	4.13	No	Yes	1	5	6
111	R:R:L218	R:R:Y136	3.52	No	Yes	1	3	6
112	R:R:Q219	R:R:Y136	3.38	No	Yes	1	5	6
113	R:R:A137	R:R:W176	5.19	No	No	0	7	9
114	R:R:L140	R:R:V175	4.47	No	No	0	6	7
115	R:R:F264	R:R:L142	3.65	Yes	No	0	9	8
116	R:R:L142	R:R:Y318	7.03	No	Yes	0	8	9
117	R:R:A143	R:R:P227	3.74	No	Yes	0	7	9
118	R:R:A143	R:R:V230	3.39	No	No	0	7	7
119	R:R:C144	R:R:T171	3.38	No	No	3	7	5
120	R:R:I145	R:R:R149	6.26	No	Yes	3	9	9
121	R:R:I145	R:R:Y318	4.84	No	Yes	3	9	9
122	R:R:M231	R:R:S146	6.13	No	No	3	8	9
123	R:R:C234	R:R:S146	3.44	No	No	0	7	9
124	R:R:S146	R:R:Y235	10.17	No	Yes	3	9	8
125	R:R:F147	R:R:Y150	3.09	No	Yes	2	6	8
126	R:R:F147	R:R:L151	4.87	No	Yes	2	6	5
127	R:R:D148	R:R:N152	6.73	Yes	No	0	8	8
128	R:R:D148	R:R:R167	5.96	Yes	Yes	2	8	4
129	R:R:R149	R:R:Y235	9.26	Yes	Yes	3	9	8
130	R:R:R149	R:R:Y318	6.17	Yes	Yes	3	9	9
131	R:R:L151	R:R:Y150	3.52	Yes	Yes	2	5	8
132	R:R:V154	R:R:Y150	11.36	No	Yes	2	7	8
133	R:R:H155	R:R:Y150	7.62	Yes	Yes	2	6	8
134	R:R:Y150	R:R:Y233	3.97	Yes	No	2	8	4
135	R:R:C234	R:R:Y150	6.72	No	Yes	0	7	8
136	R:R:H237	R:R:Y150	4.36	No	Yes	2	4	8
137	R:R:H155	R:R:L151	3.86	Yes	Yes	2	6	5
138	R:R:L151	R:R:R167	3.64	Yes	Yes	2	5	4
139	R:R:I153	R:R:I238	5.89	No	No	0	8	8
140	R:R:H155	R:R:V154	4.15	Yes	No	2	6	7
141	R:R:V154	R:R:V241	4.81	No	No	0	7	5
142	R:R:H155	R:R:Q158	3.71	Yes	No	0	6	4
143	R:R:Q158	R:R:R162	14.02	No	No	0	4	4
144	R:R:G163	R:R:L159	3.42	No	No	0	6	6
145	R:R:R161	R:R:R162	5.33	No	No	0	4	4
146	R:R:G163	R:R:P164	4.06	No	No	0	6	6
147	R:R:F182	R:R:L178	4.87	No	No	0	5	4
148	R:R:F182	R:R:L218	8.53	No	No	1	5	3
149	R:R:D186	R:R:L190	8.14	No	No	1	4	5
150	R:R:D186	R:R:Y205	16.09	No	Yes	1	4	3
151	R:R:F189	R:R:I188	6.28	No	No	0	5	4
152	R:R:F189	R:R:F207	11.79	No	Yes	0	5	4
153	R:R:L190	R:R:Y205	9.38	No	Yes	1	5	3
154	R:R:N206	R:R:S191	10.43	No	No	0	4	4
155	R:R:H193	R:R:Q204	13.6	No	No	0	3	3
156	R:R:H194	R:R:N199	6.38	No	No	0	2	5
157	R:R:H194	R:R:T201	6.85	No	No	0	2	5
158	R:R:D195	R:R:R197	7.15	No	No	0	2	4
159	R:R:F207	R:R:Y205	10.32	Yes	Yes	0	4	3
160	R:R:L215	R:R:Y205	3.52	No	Yes	0	5	3
161	L:L:?1	R:R:Y205	5.2	Yes	Yes	1	0	3
162	R:R:F207	R:R:G211	3.01	Yes	No	0	4	4
163	R:R:F207	R:R:R212	4.28	Yes	No	0	4	4
164	R:R:Q209	R:R:R212	18.69	No	No	0	2	4
165	R:R:R216	R:R:V275	3.92	Yes	No	1	3	5
166	R:R:D278	R:R:R216	7.15	No	Yes	1	5	3
167	R:R:I279	R:R:R216	5.01	No	Yes	1	5	3
168	R:R:K300	R:R:R216	4.95	No	Yes	1	5	3
169	R:R:Q219	R:R:Y271	3.38	No	Yes	1	5	6
170	L:L:?1	R:R:Q219	4.22	Yes	No	1	0	5
171	R:R:H272	R:R:L220	3.86	No	No	0	8	4
172	R:R:L220	R:R:L276	4.15	No	No	0	4	5
173	R:R:F224	R:R:L225	3.65	Yes	No	0	8	4
174	R:R:F224	R:R:L228	4.87	Yes	No	0	8	7
175	R:R:F224	R:R:T269	6.49	Yes	Yes	0	8	5
176	R:R:F224	R:R:H272	14.71	Yes	No	0	8	8
177	R:R:L226	R:R:P227	3.28	No	Yes	0	6	9
178	R:R:F264	R:R:L228	3.65	Yes	No	0	9	7
179	R:R:M231	R:R:Y235	4.79	No	Yes	3	8	8
180	R:R:H237	R:R:Y233	16.33	No	No	2	4	4
181	R:R:V257	R:R:Y235	10.09	No	Yes	0	7	8
182	R:R:V261	R:R:Y235	5.05	No	Yes	0	8	8
183	R:R:L239	R:R:M254	4.24	No	Yes	0	5	6
184	R:R:L239	R:R:V257	2.98	No	No	0	5	7
185	R:R:L242	R:R:M254	4.24	No	Yes	0	8	6
186	R:R:L243	R:R:M254	4.24	No	Yes	0	4	6
187	R:R:R250	R:R:S245	3.95	No	No	0	6	4
188	R:R:G247	R:R:Q248	3.29	No	No	0	3	3
189	R:R:L251	R:R:R250	6.07	No	No	0	5	6
190	R:R:L251	R:R:R255	6.07	No	No	0	5	5
191	R:R:L256	R:R:V321	7.45	No	No	0	8	7
192	R:R:V260	R:R:Y318	6.31	No	Yes	0	8	9
193	R:R:F264	R:R:W268	5.01	Yes	Yes	1	9	9
194	R:R:F264	R:R:H310	5.66	Yes	No	1	9	9
195	R:R:C267	R:R:L266	3.17	No	No	0	9	5
196	R:R:C267	R:R:H310	8.85	No	No	0	9	9
197	R:R:W268	R:R:Y271	4.82	Yes	Yes	1	9	6
198	R:R:G307	R:R:W268	9.85	No	Yes	0	8	9
199	R:R:H310	R:R:W268	6.35	No	Yes	1	9	9
200	R:R:P270	R:R:T269	3.5	No	Yes	0	9	5
201	R:R:L273	R:R:T269	4.42	No	Yes	0	6	5
202	R:R:P270	R:R:T303	5.25	No	No	0	9	7
203	R:R:H272	R:R:Y271	7.62	No	Yes	0	8	6
204	R:R:V275	R:R:Y271	8.83	No	Yes	1	5	6
205	R:R:K300	R:R:Y271	3.58	No	Yes	1	5	6
206	R:R:T303	R:R:Y271	8.74	No	Yes	0	7	6
207	R:R:S304	R:R:Y271	5.09	No	Yes	1	5	6
208	L:L:?1	R:R:Y271	11.14	Yes	Yes	1	0	6
209	R:R:A299	R:R:V274	3.39	No	No	0	5	4
210	R:R:T303	R:R:V274	3.17	No	No	0	7	4
211	R:R:I279	R:R:V275	3.07	No	No	1	5	5
212	R:R:D278	R:R:D282	6.65	No	No	0	5	2
213	R:R:D278	R:R:K300	5.53	No	No	1	5	5
214	R:R:L286	R:R:M281	7.07	No	No	0	1	3
215	R:R:M281	R:R:R292	3.72	No	No	0	3	3
216	R:R:A287	R:R:N289	4.69	No	No	0	1	5
217	R:R:A287	R:R:R292	5.53	No	No	0	1	3
218	R:R:E293	R:R:R288	16.28	No	No	5	1	4
219	R:R:G291	R:R:R295	3	No	No	0	2	3
220	L:L:?1	R:R:S301	4.76	Yes	No	1	0	4
221	R:R:S304	R:R:Y308	3.82	No	Yes	1	5	6
222	L:L:?1	R:R:S304	6.66	Yes	No	1	0	5
223	L:L:?1	R:R:Y308	11.88	Yes	Yes	1	0	6
224	R:R:N314	R:R:P315	8.15	No	No	0	9	9
225	R:R:A319	R:R:F325	8.32	No	Yes	4	7	8
226	R:R:F320	R:R:F325	5.36	No	Yes	0	7	8
227	R:R:R326	R:R:V323	3.92	No	No	0	8	5
228	R:R:K324	R:R:R328	4.95	No	Yes	0	6	5
229	R:R:M329	R:R:W330	5.82	No	No	0	6	2
230	R:R:L336	R:R:R335	3.64	No	No	0	4	4
231	R:R:D297	R:R:S48	2.94	No	No	0	4	4
232	R:R:G305	R:R:Y308	2.9	No	Yes	0	5	6
233	R:R:F207	R:R:P208	2.89	Yes	No	0	4	4
234	R:R:F264	R:R:P227	2.89	Yes	Yes	0	9	9
235	R:R:P164	R:R:R167	2.88	No	Yes	0	6	4
236	R:R:Q116	R:R:V115	2.87	No	No	0	3	4
237	R:R:I133	R:R:L180	2.85	No	No	0	6	4
238	R:R:I238	R:R:L242	2.85	No	No	0	8	8
239	R:R:L63	R:R:M309	2.83	No	No	0	7	5
240	R:R:I133	R:R:N134	2.83	No	Yes	0	6	8
241	R:R:G128	R:R:W109	2.81	No	Yes	0	6	5
242	R:R:L78	R:R:L93	2.77	Yes	Yes	0	7	6
243	R:R:L79	R:R:L93	2.77	No	Yes	0	4	6
244	R:R:L313	R:R:L316	2.77	No	No	0	6	6
245	R:R:C179	R:R:Y136	2.69	No	Yes	0	8	6
246	R:R:F51	R:R:V302	2.62	No	No	0	5	6
247	R:R:F119	R:R:V111	2.62	Yes	No	0	7	4
248	R:R:C124	R:R:W109	2.61	No	Yes	1	9	5
249	R:R:C203	R:R:W109	2.61	No	Yes	1	9	5
250	R:R:F187	R:R:I188	2.51	No	No	0	4	4
251	R:R:M254	R:R:R250	2.48	Yes	No	0	6	6
252	R:R:M329	R:R:R326	2.48	No	No	0	6	8
253	R:R:F320	R:R:L316	2.44	No	No	0	7	6
254	R:R:L256	R:R:R252	2.43	No	No	0	8	7
255	R:R:L286	R:R:R288	2.43	No	No	0	1	4
256	R:R:L317	R:R:Y318	2.34	No	Yes	0	8	9
257	R:R:E327	R:R:R328	2.33	No	Yes	0	5	5
258	R:R:R328	R:R:R81	2.13	Yes	Yes	0	5	5
259	R:R:G223	R:R:P227	2.03	No	Yes	0	5	9
260	R:R:A73	R:R:G70	1.95	No	No	0	7	7
261	R:R:A75	R:R:G72	1.95	No	No	0	7	4
262	R:R:A137	R:R:G138	1.95	No	No	0	7	9
263	R:R:A139	R:R:G223	1.95	No	No	0	8	5
264	R:R:P164	R:R:P165	1.95	No	No	0	6	2
265	R:R:A214	R:R:G211	1.95	No	No	0	3	4
266	R:R:A222	R:R:G223	1.95	No	No	0	5	5
267	R:R:A285	R:R:G284	1.95	No	No	0	1	1
268	R:R:C43	R:R:P44	1.88	No	No	0	9	2
269	R:R:A114	R:R:P57	1.87	No	No	0	5	4
270	R:R:G291	R:R:S294	1.86	No	No	0	2	3
271	R:R:G322	R:R:V321	1.84	No	No	0	8	7
272	R:R:A192	R:R:C203	1.81	No	No	0	5	9
273	R:R:A137	R:R:A98	1.79	No	No	0	7	8
274	R:R:G67	R:R:L66	1.71	No	No	0	8	6
275	R:R:G120	R:R:L123	1.71	No	No	0	8	6
276	R:R:C144	R:R:V175	1.71	No	No	0	7	7
277	R:R:C179	R:R:V175	1.71	No	No	0	8	7
278	R:R:G177	R:R:L180	1.71	No	No	0	4	4
279	R:R:A84	R:R:T83	1.68	No	No	0	7	6
280	R:R:A166	R:R:T169	1.68	No	No	0	4	4
281	R:R:A192	R:R:T201	1.68	No	No	0	5	5
282	R:R:A265	R:R:T269	1.68	No	Yes	0	5	5
283	R:R:L56	R:R:P57	1.64	Yes	No	0	5	4
284	R:R:L184	R:R:P185	1.64	No	No	0	4	7
285	R:R:L306	R:R:P270	1.64	No	No	0	8	9
286	R:R:V217	R:R:V221	1.6	No	No	0	4	5
287	R:R:V274	R:R:V296	1.6	No	No	0	4	4
288	R:R:T213	R:R:V217	1.59	No	No	0	1	4
289	R:R:A75	R:R:L93	1.58	No	Yes	0	7	6
290	R:R:A253	R:R:L242	1.58	No	No	0	7	8
291	R:R:A263	R:R:L317	1.58	No	No	0	6	8
292	R:R:L93	R:R:V97	1.49	Yes	No	0	6	6
293	R:R:L101	R:R:V97	1.49	No	No	0	5	6
294	R:R:L123	R:R:V126	1.49	No	No	0	6	5
295	R:R:L220	R:R:V221	1.49	No	No	0	4	5
296	R:R:L239	R:R:V258	1.49	No	No	0	5	5
297	R:R:L317	R:R:V259	1.49	No	No	0	8	5
298	R:R:L266	R:R:V262	1.49	No	No	0	5	5
299	R:R:L283	R:R:T213	1.47	No	No	0	1	1
300	R:R:P44	R:R:R197	1.44	No	No	0	2	4
301	R:R:L198	R:R:L49	1.38	No	No	0	1	3
302	R:R:L178	R:R:L181	1.38	No	No	0	4	5
303	R:R:R161	R:R:T157	1.29	No	No	0	4	5
304	R:R:D195	R:R:H194	1.26	No	No	0	2	2
305	R:R:H202	R:R:Q204	1.24	No	No	0	3	3
306	R:R:F187	R:R:L184	1.22	No	No	0	4	4
307	R:R:R252	R:R:R326	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L56	4.52857	7	1	5
2	R:R:Y60	8.785	6	1	8
3	R:R:V74	3.858	5	4	9
4	R:R:L78	3.926	5	4	7
5	R:R:R81	3.7975	4	0	5
6	R:R:F91	4.685	4	3	7
7	R:R:L93	2.1525	4	0	6
8	R:R:D99	6.1725	4	6	9
9	R:R:W109	7.27429	7	1	5
10	R:R:W117	8.0825	4	1	9
11	R:R:F119	5.706	5	1	7
12	R:R:F131	8.502	5	1	5
13	R:R:N134	5.86	4	0	8
14	R:R:Y136	3.776	5	1	6
15	R:R:D148	6.8125	4	2	8
16	R:R:R149	6.3925	4	3	9
17	R:R:Y150	5.80571	7	2	8
18	R:R:L151	3.9725	4	2	5
19	R:R:H155	4.835	4	2	6
20	R:R:R167	4.1075	4	2	4
21	R:R:Y205	8	6	1	3
22	R:R:F207	6.458	5	0	4
23	R:R:R216	5.2575	4	1	3
24	R:R:F224	7.43	4	0	8
25	R:R:P227	2.985	4	0	9
26	R:R:Y235	7.872	5	3	8
27	R:R:M254	3.8	4	0	6
28	R:R:F264	4.172	5	1	9
29	R:R:W268	6.81	5	1	9
30	R:R:T269	4.0225	4	0	5
31	R:R:Y271	6.65	8	1	6
32	R:R:Y308	7.315	6	1	6
33	R:R:Y318	5.338	5	3	9
34	R:R:F325	7.1	5	4	8
35	R:R:R328	4.17167	6	4	5
36	L:L:?1	9.72583	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D195	R:R:H194	12.1222	1.26	No	No	0	2	2
2	R:R:H194	R:R:T201	16.703	6.85	No	No	0	2	5
3	R:R:A192	R:R:T201	19.1275	1.68	No	No	0	5	5
4	R:R:A192	R:R:C203	23.9389	1.81	No	No	0	5	9
5	R:R:C203	R:R:W109	24.9361	2.61	No	Yes	1	9	5
6	L:L:?1	R:R:W109	53.1505	28.14	Yes	Yes	1	0	5
7	L:L:?1	R:R:L56	41.5207	5.26	Yes	Yes	1	0	5
8	R:R:D52	R:R:L56	33.5681	4.07	No	Yes	0	5	5
9	R:R:D297	R:R:D52	31.393	6.65	No	No	0	4	5
10	R:R:D297	R:R:S48	29.4671	2.94	No	No	0	4	4
11	R:R:Q45	R:R:S48	18.3796	4.33	No	No	0	4	4
12	R:R:Q45	R:R:R288	13.8236	3.5	No	No	5	4	4
13	R:R:F55	R:R:L56	10.589	4.87	No	Yes	0	4	5
14	L:L:?1	R:R:Y60	43.6335	12.63	Yes	Yes	1	0	8
15	R:R:L59	R:R:Y60	47.8591	5.86	No	Yes	0	6	8
16	R:R:L59	R:R:L63	48.3079	8.3	No	No	0	6	7
17	R:R:C312	R:R:L63	43.4341	3.17	No	No	0	8	7
18	R:R:C312	R:R:G67	40.9785	3.92	No	No	0	8	8
19	R:R:G67	R:R:V103	33.5369	3.68	No	No	0	8	6
20	R:R:L68	R:R:V103	31.0315	2.98	No	No	0	6	6
21	R:R:L104	R:R:L68	23.4403	6.92	No	No	0	5	6
22	R:R:L104	R:R:T100	20.885	2.95	No	No	0	5	7
23	R:R:N71	R:R:T100	18.3172	4.39	No	No	0	9	7
24	R:R:D99	R:R:N71	10.5017	6.73	Yes	No	0	9	9
25	R:R:T105	R:R:W109	11.9103	4.85	No	Yes	1	7	5
26	R:R:L130	R:R:T105	11.9539	4.42	No	No	0	5	7
27	R:R:L101	R:R:N134	57.9744	6.87	No	Yes	0	5	8
28	R:R:L101	R:R:V97	56.4537	1.49	No	No	0	5	6
29	R:R:L93	R:R:V97	55.2696	1.49	Yes	No	0	6	6
30	R:R:L78	R:R:L93	50.5703	2.77	Yes	Yes	0	7	6
31	R:R:F131	R:R:L102	58.0929	6.09	Yes	No	0	5	6
32	R:R:L102	R:R:N134	56.4413	6.87	No	Yes	0	6	8
33	R:R:F325	R:R:L78	27.6597	6.09	Yes	Yes	4	8	7
34	R:R:F325	R:R:V77	18.2362	9.18	Yes	No	0	8	7
35	R:R:M329	R:R:V77	16.2418	4.56	No	No	0	6	7
36	R:R:L78	R:R:R328	30.7448	3.64	Yes	Yes	4	7	5
37	R:R:R328	R:R:R81	12.1097	2.13	Yes	Yes	0	5	5
38	R:R:L85	R:R:R328	17.5132	3.64	No	Yes	4	6	5
39	R:R:L85	R:R:T90	17.694	2.95	No	No	0	6	6
40	L:L:?1	R:R:F135	63.3344	4.63	Yes	No	0	0	7
41	R:R:F135	R:R:W268	51.1686	8.02	No	Yes	0	7	9
42	R:R:F264	R:R:W268	100	5.01	Yes	Yes	1	9	9
43	R:R:F264	R:R:L142	94.584	3.65	Yes	No	0	9	8
44	R:R:L142	R:R:Y318	93.2814	7.03	No	Yes	0	8	9
45	R:R:R149	R:R:Y318	82.6987	6.17	Yes	Yes	3	9	9
46	R:R:R149	R:R:T88	40.8289	3.88	Yes	No	0	9	8
47	R:R:D148	R:R:T88	39.4453	8.67	Yes	No	0	8	8
48	L:L:?1	R:R:Y271	75.0078	11.14	Yes	Yes	1	0	6
49	R:R:W268	R:R:Y271	60.4799	4.82	Yes	Yes	1	9	6
50	R:R:D148	R:R:S87	14.2848	5.89	Yes	No	2	8	6
51	R:R:D148	R:R:R167	22.0443	5.96	Yes	Yes	2	8	4
52	R:R:T90	R:R:V168	17.2452	4.76	No	No	0	6	8
53	R:R:S87	R:R:V168	18.6476	3.23	No	No	0	6	8
54	R:R:C144	R:R:V175	18.8969	1.71	No	No	0	7	7
55	R:R:C179	R:R:V175	21.9882	1.71	No	No	0	8	7
56	R:R:C179	R:R:Y136	23.7333	2.69	No	Yes	0	8	6
57	R:R:F135	R:R:Y136	16.9025	5.16	No	Yes	0	7	6
58	R:R:Q219	R:R:Y136	17.3387	3.38	No	Yes	1	5	6
59	L:L:?1	R:R:Q219	15.0888	4.22	Yes	No	1	0	5
60	R:R:C144	R:R:F91	16.1795	5.59	No	Yes	3	7	7
61	R:R:C172	R:R:F91	17.4883	4.19	No	Yes	0	7	7
62	R:R:C172	R:R:H94	15.0265	14.74	No	No	0	7	9
63	R:R:H94	R:R:W176	10.0654	7.41	No	No	0	9	9
64	R:R:C124	R:R:W117	36.3602	7.84	No	Yes	1	9	9
65	R:R:F119	R:R:W117	22.0941	11.02	Yes	Yes	1	7	9
66	R:R:F189	R:R:I188	10.9318	6.28	No	No	0	5	4
67	R:R:F189	R:R:F207	13.082	11.79	No	Yes	0	5	4
68	R:R:F207	R:R:Y205	25.7214	10.32	Yes	Yes	0	4	3
69	L:L:?1	R:R:Y205	35.2509	5.2	Yes	Yes	1	0	3
70	R:R:F264	R:R:P227	17.6192	2.89	Yes	Yes	0	9	9
71	R:R:R149	R:R:Y235	58.9342	9.26	Yes	Yes	3	9	8
72	R:R:S146	R:R:Y235	25.2166	10.17	No	Yes	3	9	8
73	R:R:C234	R:R:S146	23.4154	3.44	No	No	0	7	9
74	R:R:L151	R:R:R167	18.0804	3.64	Yes	Yes	2	5	4
75	R:R:C234	R:R:Y150	21.7763	6.72	No	Yes	0	7	8
76	R:R:H155	R:R:L151	11.5675	3.86	Yes	Yes	2	6	5
77	R:R:V257	R:R:Y235	30.134	10.09	No	Yes	0	7	8
78	R:R:L239	R:R:V257	27.8841	2.98	No	No	0	5	7
79	R:R:L239	R:R:M254	23.3655	4.24	No	Yes	0	5	6
80	R:R:H155	R:R:Q158	16.5721	3.71	Yes	No	0	6	4
81	R:R:Q158	R:R:R162	12.4462	14.02	No	No	0	4	4
82	R:R:H272	R:R:Y271	17.7127	7.62	No	Yes	0	8	6
83	R:R:H272	R:R:L220	12.6208	3.86	No	No	0	8	4
84	R:R:T303	R:R:Y271	13.0383	8.74	No	Yes	0	7	6
85	R:R:M329	R:R:R326	12.1907	2.48	No	No	0	6	8
86	R:R:L286	R:R:R288	11.5862	2.43	No	No	0	1	4
87	L:L:?1	R:R:F131	46.4444	16.2	Yes	Yes	1	0	5
88	R:R:C124	R:R:W109	37.2826	2.61	No	Yes	1	9	5
89	R:R:F91	R:R:I145	11.0813	3.77	Yes	No	3	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D52	R:R:L56	4.07	0	No	Yes	5	5	2	1
R:R:F55	R:R:L56	4.87	0	No	Yes	4	5	2	1
R:R:F55	R:R:L59	7.31	0	No	No	4	6	2	2
R:R:L56	R:R:Y60	8.21	1	Yes	Yes	5	8	1	1
R:R:A113	R:R:L56	3.15	1	No	Yes	5	5	1	1
R:R:L56	R:R:S301	4.5	1	Yes	No	5	4	1	1
L:L:?1	R:R:L56	5.26	1	Yes	Yes	0	5	0	1
R:R:L59	R:R:Y60	5.86	0	No	Yes	6	8	2	1
R:R:L106	R:R:Y60	14.07	1	No	Yes	8	8	2	1
R:R:A110	R:R:Y60	4	0	No	Yes	7	8	2	1
R:R:Y308	R:R:Y60	7.94	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:Y60	12.63	1	Yes	Yes	0	8	0	1
R:R:F131	R:R:L102	6.09	1	Yes	No	5	6	1	2
R:R:T105	R:R:W109	4.85	1	No	Yes	7	5	2	1
R:R:F131	R:R:T105	3.89	1	Yes	No	5	7	1	2
R:R:L106	R:R:Y308	7.03	1	No	Yes	8	6	2	1
R:R:A127	R:R:W109	3.89	0	No	Yes	5	5	2	1
R:R:F131	R:R:W109	6.01	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:W109	28.14	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:A113	5.99	1	Yes	No	0	5	0	1
R:R:C124	R:R:C203	7.28	1	No	No	9	9	2	2
R:R:F131	R:R:Y308	10.32	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:F131	16.2	1	Yes	Yes	0	5	0	1
R:R:D186	R:R:N132	13.46	1	No	No	4	4	2	2
R:R:N132	R:R:Y205	3.49	1	No	Yes	4	3	2	1
R:R:F135	R:R:Y136	5.16	0	No	Yes	7	6	1	2
R:R:F135	R:R:W268	8.02	0	No	Yes	7	9	1	2
L:L:?1	R:R:F135	4.63	1	Yes	No	0	7	0	1
R:R:Q219	R:R:Y136	3.38	1	No	Yes	5	6	1	2
R:R:D186	R:R:L190	8.14	1	No	No	4	5	2	2
R:R:D186	R:R:Y205	16.09	1	No	Yes	4	3	2	1
R:R:L190	R:R:Y205	9.38	1	No	Yes	5	3	2	1
R:R:F207	R:R:Y205	10.32	0	Yes	Yes	4	3	2	1
R:R:L215	R:R:Y205	3.52	0	No	Yes	5	3	2	1
L:L:?1	R:R:Y205	5.2	1	Yes	Yes	0	3	0	1
R:R:Q219	R:R:Y271	3.38	1	No	Yes	5	6	1	1
L:L:?1	R:R:Q219	4.22	1	Yes	No	0	5	0	1
R:R:W268	R:R:Y271	4.82	1	Yes	Yes	9	6	2	1
R:R:H272	R:R:Y271	7.62	0	No	Yes	8	6	2	1
R:R:V275	R:R:Y271	8.83	1	No	Yes	5	6	2	1
R:R:K300	R:R:Y271	3.58	1	No	Yes	5	6	2	1
R:R:T303	R:R:Y271	8.74	0	No	Yes	7	6	2	1
R:R:S304	R:R:Y271	5.09	1	No	Yes	5	6	1	1
L:L:?1	R:R:Y271	11.14	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S301	4.76	1	Yes	No	0	4	0	1
R:R:S304	R:R:Y308	3.82	1	No	Yes	5	6	1	1
L:L:?1	R:R:S304	6.66	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y308	11.88	1	Yes	Yes	0	6	0	1
R:R:G305	R:R:Y308	2.9	0	No	Yes	5	6	2	1
R:R:G128	R:R:W109	2.81	0	No	Yes	6	5	2	1
R:R:C124	R:R:W109	2.61	1	No	Yes	9	5	2	1
R:R:C203	R:R:W109	2.61	1	No	Yes	9	5	2	1
R:R:L56	R:R:P57	1.64	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HNL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	272
Number of Links	307
Number of Hubs	36
Number of Links mediated by Hubs	154
Number of Communities	6
Number of Nodes involved in Communities	66
Number of Links involved in Communities	94

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	48608
Length Of Smallest Path	3
Average Path Length	12.5155
Length of Longest Path	28
Minimum Path Strength	1.43
Average Path Strength	5.943
Maximum Path Strength	18.28
Minimum Path Correlation	0.7
Average Path Correlation	0.92609
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.8589
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8933
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • chemokine binding • cytokine binding • C-X-C chemokine receptor activity • C-C chemokine binding • C-X-C chemokine binding • oxidoreductase activity • monooxygenase activity • Oplophorus-luciferin 2-monooxygenase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen • luciferin monooxygenase activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell adhesion • regulation of cell adhesion • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • immune response • immune system process • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of biological process • response to external stimulus • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • apoptotic process • cell death • programmed cell death • calcium-mediated signaling • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • positive regulation of cellular process • negative regulation of programmed cell death • negative regulation of biological process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic process • negative regulation of cellular process • positive regulation of cell population proliferation • regulation of cell population proliferation • cell chemotaxis • cell migration • cell motility • cell surface receptor signaling pathway • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • negative regulation of blood vessel morphogenesis • negative regulation of developmental process • negative regulation of angiogenesis • negative regulation of vasculature development • negative regulation of multicellular organismal process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • regulation of cell motility • regulation of leukocyte migration • leukocyte migration • regulation of cell migration • regulation of immune system process • lymphocyte chemotaxis • lymphocyte migration • mononuclear cell migration • T cell chemotaxis • T cell migration • leukocyte chemotaxis • negative regulation of cell population proliferation • endothelial cell proliferation • negative regulation of endothelial cell proliferation • regulation of endothelial cell proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • negative regulation of epithelial cell proliferation • bioluminescence • periplasmic space • cell surface • external side of plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	4AI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	4AI
Name	(3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide
Synonyms	PS372424
Identifier
Formula	C33 H44 N6 O4
Molecular Weight	588.74
SMILES
PubChem	12000484
Formal Charge	0
Total Atoms	87
Total Chiral Atoms	2
Total Bonds	90
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49682
Sequence	>8HNL_nogp_Chain_R P C P Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R R T A L S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V Q W V F G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A T Q L Y R R G P P A R V T L T C L A V W G L C L L F A L P D F I F L S A H H D E R L N A T H C Q Y N F P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R G Q R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G A L A R N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K F R E R M W M L L L R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HNK	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-	Gi1/β1/γ2	3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL11	-		3.01	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-	Gi1/β1/γ2	2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNL (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	PS372424	-		2.98	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-	Gi1/β1/γ2	2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNM (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11222	-		2.94	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8HNN	A	Protein	Chemokine	CXCR3	Homo sapiens	SCH546738	-	-	3.6	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2W	A	Protein	Chemokine	CXCR3	Homo sapiens	AMG487	-	-	3	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-	Gi1/β1/γ2	3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8K2X (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	CXCL10	-		3.2	2023-11-29	doi.org/10.1038/s41594-023-01175-5
	8XXY	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	-	3.68	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-	Go/β1/γ2	3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XXZ (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	-	-		3.3	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYI	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	-	3.16	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-	Go/β1/γ2	3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8XYK (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF10661	-		3.03	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0H	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	-	3.53	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-	Go/β1/γ2	3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w
	8Y0N (No Gprot)	A	Protein	Chemokine	CXCR3	Homo sapiens	VUF11418	-		3.07	2025-02-26	doi.org/10.1038/s41467-025-58264-w

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