Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.43 3.0175449
2G.S1.02 4.771585
3G.S1.04 2.69125487
4G.H1.01 6.34754149
5G.H1.04 3.69375407
6G.H1.07 4.41125409
7G.H1.08 4.32875488
8G.S2.08 8.36875485
9G.s2s3.01 6.8484
10G.S3.01 5.492584
11G.S3.03 6.921587
12G.S3.04 6.905416
13G.S3.05 3.331587
14G.S3.06 7.31515
15G.s3h2.03 3.57419
16G.H2.03 4.09125419
17G.H2.04 4.062509
18G.H2.06 4.97563819
19G.H2.07 5.121519
20G.H2.09 5.26875418
21G.h2s4.01 5.33719
22G.S4.02 4.6175418
23G.S4.04 7.03625439
24G.S4.06 4.465407
25G.s4h3.04 6.047538
26G.s4h3.05 6.1075439
27G.H3.01 6.253754159
28G.H3.06 4.3525436
29G.H3.09 5.51429739
30G.H3.13 3.57875435
31G.H3.17 7.31167615
32G.H3.18 4.74125419
33G.S5.03 3.28875498
34G.S5.04 3.88375439
35G.S5.05 4.596599
36G.S5.06 5.16875408
37G.HG.04 5.30417639
38G.hgh4.01 4.23375436
39G.hgh4.02 5.35667637
40G.hgh4.05 7.6375407
41G.H4.03 5.01634
42G.H4.10 8.43625436
43G.H4.15 4.665508
44G.S6.02 6.94167697
45G.S6.04 8.296599
46G.S6.05 3.972534
47G.s6h5.01 6.1125499
48G.s6h5.05 3.20625409
49G.H5.06 9.14875493
50G.H5.08 5.65667688
51G.H5.11 3.8975488
52G.H5.20 3.6275409
53G.H5.25 3.62625407
54G.H5.26 7.168505
55b.1x11 2.57125408
56b.1x15 3.05417
57b.1x19 5.8775416
58b.h2x5 3.91125405
59b.lhb1x6 4.613754173
60b.lhb1x11 3.57125404
61b.l1x3 8.18357749
62b.l1x6 9.49625419
63b.b2x1 5.836518
64b.b2x5 5.5647
65b.b3x4 5.26449
66b.l3x2 5.39875449
67b.b4x2 3.93408
68b.b4x5 4.15457
69b.b4x6 7.98214749
70b.b5x2 5.55125407
71b.b5x3 5.92083649
72b.b5x5 4.6275455
73b.b5x7 5.5275457
74b.l5x1 4.436558
75b.l5x5 6.07187819
76b.b6x5 3.885756
77b.l6x5 5.678754124
78b.b7x1 6.70754124
79b.b7x4 4.5025458
80b.l7x2 3.695419
81b.l7x5 4.46125456
82b.b8x3 4.06375406
83b.b8x4 4.44071756
84b.l8x1 2.93625455
85b.l8x8 4.665454
86b.b9x3 6.0375456
87b.l9x3 5.26286719
88b.l9x6 5.11688818
89b.b10x3 3.68875408
90b.b10x5 4.21917609
91b.l10x1 3.217573
92b.b11x5 3.97476
93b.l11x2 6.165519
94b.b12x2 4.815417
95b.b12x3 3.23125478
96b.b12x5 3.35875476
97b.b12x6 6.89583618
98b.b13x7 6.961577
99b.l13x3 7.74583679
100b.l13x6 4.648519
101b.l13x7 3.893579
102b.b14x3 5.06475
103b.b15x1 6.576579
104b.b15x2 6.24416
105b.b15x3 4.90875479
106b.l15x1 4.6975417
107b.l15x2 6.0275479
108b.b16x4 8.158576
109b.b16x5 4.47375405
110b.b16x6 7.68833678
111b.l16x3 5.03254133
112b.b17x4 5.864135
113b.b17x5 8.02417
114b.b17x7 7.825518
115b.l17x3 9.57619
116b.l17x6 6.467519
117b.b18x3 5.28875418
118b.l18x1 5.73917666
119b.l18x2 5.4875467
120b.b19x2 5.61071716
121b.b19x4 5.785418
122b.l19x1 6.68419
123b.l19x2 5.56167619
124b.b20x4 7.98618
125b.b20x6 6.485616
126b.b21x1 11.08417
127b.b21x5 5.7875464
128b.b21x7 5.2825665
129b.l21x5 3.341564
130b.b22x5 4.535567
131b.l22x5 6.004176179
132b.b23x2 3.88375466
133b.b23x6 6.48167667
134b.l23x1 8.56375416
135b.b24x4 6.59566
136b.b24x6 6.265468
137b.l24x3 4.4825405
138b.b25x3 7.505465
139b.l25x3 7.296676109
140b.l25x4 5.705405
141b.l25x6 11.9275418
142b.l26x5 5.57625445
143b.l27x1 9.08429719
144b.l27x2 5.3415109
145b.b28x4 7.73254106
146b.b28x6 7.483577109
147b.b28x7 6.875449
148g.h1x11 2.412509
149g.l1x4 4.26333618
150g.h2x11 8.3775466
151g.ctx3 5.420836189
152g.ctx6 3.611506
153g.ctx14 5.605449
154g.ctx15 6.6075449
155g.ctx16 4.63687848
156Lig 22.16872320
1571x50 5.19375409
1581x53 4.50254199
1592x41 3.6725406
1602x42 4.56708
1612x45 6.65875408
1622x46 4.16429
1632x50 7.236529
1642x51 2.67125407
165E1x49 7.1925426
166E1x52 3.644507
1673x22 3.25875401
1683x27 2.645406
1693x29 4.85375428
1703x33 3.4925425
1713x43 5.85625428
1723x50 5.05529
1733x54 3.66375409
174I2x53 3.741254117
175I2x57 6.749176119
1764x64 5.04875428
1774x65 9.355428
178E2.R171 3.4575421
179E2x52 7.714527
1805x35 3.40875424
1815x36 4.98375423
1825x43 4.66375429
1835x47 7.093754209
1845x50 3.40125409
1855x58 5.59509
186I3.F368 9.0725495
1876x32 2.28409
1886x44 4.52529
1896x48 6.145629
1906x49 3.993754206
1916x51 9.6625429
192E3.D404 5.69875424
1937x30 3.8825407
1947x45 6.26125429
1957x49 6.253529
1967x53 4.58571729
1978x50 5.299176199
198E2.F176 5.544520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x2 b.b4x6 11.66183.985NoYes459
22x42 3x46 28.76394.695YesNo089
33x46 3x50 10.11494.385NoYes299
43x50 G.H5.25 24.26033.645YesYes097
56x36 G.H5.25 13.72412.98NoYes087
66x36 7x56 19.03252.235NoNo087
77x56 8x51 19.1440.605NoNo079
87x55 8x51 19.25770.605NoNo079
97x55 8x50 19.82946.09NoYes079
108x50 I1.M52 88.96753.735YesNo099
118x53 I1.M52 89.21764.32NoNo079
128x53 b.l25x4 89.45946.915NoYes075
13b.l25x4 b.l27x2 91.51472.66YesYes059
14b.l25x3 b.l27x2 28.73885.04YesYes1099
15b.b28x6 b.l25x3 26.33672.645YesYes1099
16b.b28x6 b.lhb1x11 25.00832.91YesYes094
173x46 7x53 19.26784.235NoYes299
182x46 7x53 12.01162.93YesYes299
192x46 2x50 14.07145.43YesYes299
201x50 2x50 57.29876.73YesYes099
211x50 7x50 60.3158.15YesNo099
221x53 7x50 60.45792.65YesNo099
231x53 8x50 67.56287.21YesYes1999
247x49 7x53 17.40284.07YesYes299
252x50 7x49 42.921110.77YesYes299
26b.b8x4 b.l5x1 11.11855.275YesYes568
27b.b4x1 b.l5x1 17.45523.42NoYes088
28b.b4x1 b.l5x4 17.82542.785NoNo088
29b.l5x4 b.l5x5 18.22852.47NoYes089
30G.H5.17 G.H5.26 16.056311.165NoYes055
31G.H5.13 G.H5.17 13.55729.68NoNo085
32G.H5.13 I3.F368 11.16978.36NoYes985
33G.h2s4.01 b.l5x5 29.51139.525YesYes199
34G.H2.07 G.h2s4.01 29.55134.01YesYes199
35G.H2.04 G.H2.07 86.14166.5YesYes099
36G.H2.04 G.H3.08 85.38584.25YesNo099
37G.H3.08 G.S4.04 85.22236.7NoYes099
38G.S4.04 G.S4.06 38.73093.93YesYes097
39G.S4.06 G.S5.06 19.19282.98YesYes078
40G.S5.06 G.S6.05 25.51947.31YesYes084
41G.HG.01 G.S6.05 23.7132.48NoYes354
42G.HG.01 G.s6h5.02 27.78557.275NoNo057
43G.H5.02 G.s6h5.02 27.07652.425NoNo047
44G.H5.02 G.S6.04 25.39122.62NoYes049
45b.l5x5 b.l7x2 31.31496.26YesYes199
46G.H2.07 b.l7x2 27.84823.42YesYes199
47G.S4.04 G.S5.04 19.48383.045YesYes399
48G.S5.04 G.S5.06 19.31214.155YesYes098
49G.H3.01 G.s4h3.03 10.74228.935YesNo1598
50G.S4.07 G.s4h3.03 13.45524.635NoNo088
51G.S4.07 G.s5hg.01 14.81072.41NoNo089
52G.s4h3.02 G.s5hg.01 16.16594.59NoNo099
53G.HG.07 G.s4h3.02 21.58433.06NoNo099
54G.HG.07 G.s4h3.04 22.92217.165NoYes398
55G.HG.04 G.s4h3.04 23.94355.16YesYes398
56G.HG.04 G.s4h3.01 12.335210.35YesNo397
57G.S5.06 G.s4h3.01 12.77466.23YesNo087
58G.H4.11 G.HG.04 12.67462.51NoYes379
59G.H4.11 G.H4.15 13.04322.51NoYes078
60G.H4.15 G.S4.06 19.47588.525YesYes087
61G.hgh4.01 G.s4h3.04 11.48153.36YesYes368
62G.H3.02 G.hgh4.01 12.8773.24NoYes386
63G.H3.02 G.H4.15 17.37553.11NoYes088
64G.H3.09 G.H4.15 19.26964.825YesYes098
65G.H3.09 G.S4.04 26.933114.47YesYes399
66b.b10x2 b.b14x3 22.13354.76NoYes065
67b.b11x5 b.b14x3 25.22426.005YesYes765
68b.b10x1 b.b11x5 35.74042.445NoYes096
69b.b10x1 b.l9x6 36.03583.815NoYes098
70G.s3h2.03 b.l9x6 38.41193.945YesYes198
71G.H2.06 b.l9x6 91.5073.58YesYes198
72G.H2.06 b.l17x6 45.11616.91YesYes199
73G.H2.06 b.l19x1 45.11623.455YesYes199
74G.H2.09 b.l27x1 40.61815.82YesYes189
75b.b26x1 b.l27x1 19.74155.56NoYes099
76b.b26x1 b.b26x2 19.32183.44NoNo097
77b.b26x2 b.b2x3 18.51114.05NoNo076
78G.H2.09 G.H2.10 45.36472.95YesNo187
79G.H2.10 b.b2x1 40.85254.035NoYes178
80b.b2x1 b.l27x1 67.05365.785YesYes189
81b.b6x1 b.l9x6 86.00734.79NoYes098
82G.H2.10 b.b6x1 86.12882.43NoNo079
83b.l1x6 b.l27x1 26.708418.565YesYes199
84b.l25x6 b.l27x1 28.04417.99YesYes189
85G.H5.20 G.H5.25 14.98873.46YesYes097
86b.l17x5 b.l17x6 45.0523.68NoYes169
87b.l17x5 b.l19x2 89.31122.205NoYes169
88b.b20x4 b.l19x2 66.55213.575YesYes189
89b.b20x4 b.b20x6 64.80543.745YesYes186
90b.b17x7 b.b20x6 51.941212.86YesYes186
91b.b17x7 b.b21x1 37.2626.565YesYes187
92b.1x19 b.b21x1 16.186811.315YesYes167
93b.1x15 b.1x19 13.70615.01YesYes176
94b.1x15 g.h1x11 24.97411.43YesYes079
95b.1x8 g.h1x11 13.73561.58NoYes059
96b.1x8 g.h1x8 12.48551.7NoNo057
97b.l17x5 b.l19x1 44.85565.155NoYes169
98b.b21x1 g.l1x4 20.54910.125YesYes178
99b.1x15 g.l1x4 13.76242.51YesYes178
100b.lhb1x11 g.ctx5 11.52585.65YesNo049
101b.l3x1 b.l5x5 54.2885.475NoYes199
102b.l1x6 b.l3x1 27.16236.1YesNo199
103b.b2x1 b.l3x1 27.11657.89YesNo189
104b.b10x2 b.b6x2 21.40222.535NoNo068
105b.b10x3 b.b6x2 21.09654.225YesNo088
106b.b10x3 b.b11x2 13.5523.27YesNo087
107b.b7x1 b.b8x3 12.32024.235YesYes046
108b.l17x3 b.l19x2 19.72715.04YesYes199
109b.b19x4 b.l17x3 17.36710.265YesYes189
110b.b19x2 b.b19x4 11.7782.59YesYes168
111b.b19x2 b.b20x6 11.73449.65YesYes166
112b.b19x2 b.l20x1 13.59663.045YesNo166
113b.b16x5 b.l20x1 18.53845.535YesNo056
114b.b16x5 b.b17x4 19.8764.855YesYes055
115b.l23x1 b.l25x6 30.583922.63YesYes168
116b.l21x7 b.l23x1 29.78036.22NoYes056
117b.b23x6 b.l21x7 27.27974.03YesNo075
118b.b22x5 b.b23x2 11.24276.7YesYes676
119b.b21x7 b.b24x6 19.43957.235YesYes658
120b.b23x6 b.b24x6 20.28345.305YesYes678
121b.l25x5 b.l27x2 99.48232.69NoYes079
1227x45 7x49 34.28096.81YesYes299
1236x48 7x45 32.12957.345YesYes299
1246x48 6x51 35.81235.305YesYes299
1256x51 Lig 27.243721.61YesYes290
1261x39 2x61 11.20853.46NoNo066
1271x39 2x57 11.71495.535NoNo069
1281x43 2x57 12.72682.435NoNo079
1291x43 1x47 13.737711.57NoNo077
1301x47 2x55 15.2522.77NoNo078
1312x51 2x55 15.75633.46YesNo078
1321x50 2x51 10.32942.75YesYes097
133b.l25x5 b.l27x1 1005.65NoYes079
134b.b2x3 b.b3x2 11.26112.825NoNo465
135G.H5.06 G.S6.04 14.488926.585YesYes939
136b.b21x7 b.b23x2 12.69684.105YesYes656
137G.H5.20 G.H5.26 12.99363.045YesYes095
138g.ctx3 g.ctx5 11.1442.71YesNo099
139G.H2.07 G.s3h2.03 30.91054.93YesYes199
1403x50 7x53 11.94213.6YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2.D167Lig3.9152NoYes0010
E3.E406Lig6.572NoYes0010
E3.D404Lig8.342YesYes0010
E3.P405Lig3.8152NoYes0010
E2.F164Lig13.1052NoYes0010
E2.K175Lig2.712NoYes0010
E2.T166Lig2.742NoYes0010
E2.R171Lig3.7552YesYes0010
7x31Lig2.6252NoYes2010
E2x51Lig2.710NoYes1010
E2x52Lig3.8852YesYes7010
2x63Lig6.432NoYes7010
3x29Lig3.2852YesYes8010
3x32Lig3.0452NoYes8010
7x38Lig8.8852NoYes4010
4x65Lig3.422YesYes8010
6x51Lig21.612YesYes9010
6x55Lig4.50NoYes8010
7x34Lig16.082NoYes8010
2x563x323.870NoNo9821
2x63E1.G863.9752NoNo7011
2x63E1x503.1752NoNo7912
E1.G86E2.R1713.752NoYes0011
E1x49E2.H16914.8352YesNo6022
E1x49E2.R1713.5052YesYes6021
3x283x293.390NoYes8821
3x294x612.652YesNo8912
3x294x6510.092YesYes8811
4x61E2x523.1550NoYes9721
4x65E2x504.8752YesNo8812
4x65E2x5219.0352YesYes8711
E2.E162E2.F1647.580NoNo0021
E2.E162E2.K1758.10NoNo0021
5x36E2x525.2752YesYes3721
5x436x514.1152YesYes9921
6x486x515.3052YesYes9921
6x516x527.622YesNo9912
E3.D404E3.P4056.442YesNo0011
E3.D404E3.E4065.8452YesNo0011
7x347x382.82NoNo8411
E1.G86Lig2.6152NoYes0010
E2.D167E2.T1662.892NoNo0011
E2.H169E2.R1712.822NoYes0021
E2.F176E2x527.222YesYes0721
5x36E2.F1767.9152YesYes3022
E3.E406E3.P4053.1452NoNo0011
6x587x312.30NoNo2221
7x24E3.D4042.170NoYes7021
2x60Lig1.50NoYes8010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
93.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
78.95Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
73.68Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
72.22Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
70.59Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
70.59Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
70.59Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
68.18Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
66.67Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
66.67Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
61.90Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
61.90Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
60.87Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
60.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
58.82Single6D26Fevipiprant6D26-DP2-Fevipiprant
58.82Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
58.82Consensusdp_offOrthosteric Liganddp2_off
58.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
58.33Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
58.33Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
57.89Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.89Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
57.14Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
57.14Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
57.14Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
56.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
56.52Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
56.25Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
56.25Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
55.56Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
55.56Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
54.55Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
54.55Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
54.55Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
54.17Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
54.17Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
54.17Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
53.85Single5GLHEndothelin-15GLH-ETB-Endothelin-1
53.85Single6IGKEndothelin-36IGK-ETB-Endothelin-3
53.33Single3OE9IT1t3OE9-CXCR4-IT1t
52.94Single6D27CAY104716D27-DP2-CAY10471
52.94Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
52.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.63Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
52.63Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
52.63Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
52.63Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
52.63Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
52.38Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
52.17Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
52.17Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
52.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
52.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
50.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
50.00Single5N2SPSB365N2S-A1-PSB36
50.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
50.00Single6IGLIRL16206IGL-ETB-IRL1620
50.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
50.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
50.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
50.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
50.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
50.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
50.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
50.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
50.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
50.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
50.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
50.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
50.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
50.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
50.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
50.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
50.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
50.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
50.00Consensusprostanoid_offOrthosteric Ligandep_off dp_off
48.15Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.15Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.15Consensusbombesin_onOrthosteric Ligandbb2_on
48.15Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
48.15Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
48.15Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
48.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
47.83Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
47.83Consensusangiotensin_onOrthosteric Ligandat1_on
47.83Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
47.83Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
47.83Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
47.83Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
47.83Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
47.62Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
47.62Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
47.62Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
47.62Single8QJ2pN1628QJ2-MC4-pN162-Gs
47.62Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
47.62Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
47.62Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
47.37Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
47.37Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.37Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
47.37Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
47.37Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
47.37Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
47.37Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
47.37Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
47.37Consensusrelaxin_onOrthosteric Ligandrxfp4_on
47.37Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
47.06Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
47.06Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
47.06Single6MH8ZM-2413856MH8-A2A-ZM-241385
47.06Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
47.06Single7AROLUF58337ARO-A2A-LUF5833-Na
47.06Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
47.06Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
46.67Single3OE6IT1t3OE6-CXCR4-IT1t
46.15Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
45.83Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.83Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
45.83Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.83Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
45.83Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.83Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
45.83Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
45.83Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
45.45Single7F8XNN90567F8X-CCKA-NN9056
45.45Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
45.45Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
45.45Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
45.45Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.45Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
45.45Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
45.45Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
45.00Single6OS2TRV0266OS2-AT1-TRV026
45.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
45.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
45.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
45.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
45.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
45.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
45.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
45.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
45.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
45.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
45.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
45.00Consensusorexin_onOrthosteric Ligandox2_on
44.83Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
44.44Single3EMLZM-2413853EML-A2A-ZM-241385
44.44Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
44.44Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
44.44Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
44.44Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
44.44Single6S0LZM-2413856S0L-A2A-ZM-241385
44.44Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
44.44Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
44.44Single8CU6LJ-45178CU6-A2A-LJ-4517
44.44Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
44.44Single8K5DGSK2560738K5D-HCA2-GSK256073
44.44Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
44.44Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
44.44Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
44.44Consensusbradykinin_onOrthosteric Ligandbk2_on
44.44Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
44.44Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
44.44Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
44.44Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
44.44Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
44.44Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
44.44Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
44.44Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
44.44Consensushca_on_gpOrthosteric Ligandhca2_on_gp
44.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
44.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
44.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
44.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
44.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
44.00Single8ZRTET-18ZRT-ETB-ET-1
44.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
43.75Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
43.75Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
43.48Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
43.48Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
43.48Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
43.48Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
43.48Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
43.48Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
43.48Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
43.48Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
42.86Single4BUONeurotensin4BUO-NTS1-Neurotensin
42.86Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
42.86Consensuscck_onOrthosteric Ligandccka_on cckb_on
42.86Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
42.86Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
42.86Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
42.86Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
42.86Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
42.31Single4XT3Fractalkine4XT3-US28-Fractalkine
42.31Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
42.31Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
42.31Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
42.31Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
42.31Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
42.11Single5IUAQ274563485IUA-A2A-Q27456348-Na
42.11Single5N2RPSB-365N2R-A2A-PSB-36-Na
42.11Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
42.11Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
42.11Single6S0QZM-2413856S0Q-A2A-ZM-241385
42.11Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
42.11Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
42.11Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
42.11Single8GNEKW-63568GNE-A2A-KW-6356-Na
42.11Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
42.11Single8S4DCMF-0198S4D-Apelin-CMF-019
42.11Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
42.11Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Consensusadenosine_offOrthosteric Liganda1_off a2_off
42.11Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
42.11Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
41.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
41.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
41.67Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
41.67Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
41.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
41.38Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
41.38Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
41.38Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
41.18Single3ODUIT1t3ODU-CXCR4-IT1t
41.18Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
41.18Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
41.18Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
41.18Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
41.18Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
41.18Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
41.18Single7XRRLemborexant7XRR-OX2-Lemborexant
41.18Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
41.18Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
40.91Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
40.91Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
40.91Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
40.91Single7XN9L-054,5227XN9-SST2-L-054,522
40.91Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
40.91Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
40.91Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
40.91Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
40.91Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
40.91Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
40.74Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
40.74Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.74Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
40.74Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
40.74Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.74Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
40.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
40.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
40.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
40.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
40.00Single7PX4PSB-21137PX4-A2A-PSB-2113
40.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
40.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
40.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
40.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
40.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
40.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
40.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
40.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
40.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
40.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
40.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
40.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
40.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
40.00Consensusneurotensin_onOrthosteric Ligandnts1_on
40.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
40.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
40.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
40.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
40.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
39.29Single8IY6Endothelin-18IY6-ETB-Endothelin-1
39.29Consensusendothelin_onOrthosteric Ligandetb_on eta_on
39.29Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
39.13Single4XT1Fractalkine4XT1-US28-Fractalkine
39.13Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
39.13Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
39.13Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
39.13Single8WDTphotoNECA8WDT-A2A-photoNECA
39.13Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
39.13Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
39.13Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
39.13Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
39.13Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
39.13Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.13Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
39.13Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
38.89Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
38.89Single5IU7Q274563465IU7-A2A-Q27456346-Na
38.89Single5IUBQ274563445IUB-A2A-Q27456344-Na
38.89Single5JTBZM-2413855JTB-A2A-ZM-241385
38.89Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
38.89Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
38.89Single5UVIZM-2413855UVI-A2A-ZM-241385
38.89Single6V9SGTPL114036V9S-OX1-GTPL11403
38.89Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
38.89Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
38.89Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
38.89Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
38.89Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
38.89Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
38.89Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
38.89Single8IHKAcifran8IHK-HCA3-Acifran
38.89Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
38.89Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
38.89Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
38.89Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
38.89Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
38.89Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
38.89Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
38.89Consensusa2_offOrthosteric Liganda2a_off
38.89Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
38.89Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
38.89Consensushca_onOrthosteric Ligandhca2_on
38.89Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
38.89Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
38.46Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
38.46Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
38.46Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
38.46Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
38.46Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
38.46Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
38.46Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
38.46Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
38.46Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
38.46Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
38.10Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
38.10Single4XEENeurotensin4XEE-NTS1-Neurotensin
38.10Single4XESNeurotensin4XES-NTS1-Neurotensin
38.10Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.10Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
38.10Single6YVRNTS8-136YVR-NTS1-NTS8-13
38.10Single7K15MKD0467K15-BLT1-MKD046-Na
38.10Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
38.10Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
38.10Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
38.10Single8JJLOlodaterol8JJL-β2-Olodaterol
38.10Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
38.10Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
38.10Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
38.10Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
38.10Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
38.10Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
38.10Consensuslpa_offOrthosteric Ligandlpa1_off
37.93Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.93Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
37.93Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
37.50Single3QAKUK-4320973QAK-A2A-UK-432097
37.50Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
37.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
37.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
37.50Single7XNACYN1548067XNA-SST2-CYN154806
37.50Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
37.50Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
37.50Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
37.50Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
37.50Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
37.04Single7SK3CXCL127SK3-ACKR3-CXCL12
37.04Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
37.04Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
37.04Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.04Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
37.04Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
37.04Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
36.84Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
36.84Single5IU8Q274563475IU8-A2A-Q27456347-Na
36.84Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
36.84Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
36.84Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
36.84Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
36.84Single5UENDU1725UEN-A1-DU172
36.84Single6TOTLemborexant6TOT-OX1-Lemborexant
36.84Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
36.84Single7PYRPSB-21157PYR-A2A-PSB-2115
36.84Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
36.84Single7UL4Alvimopan7UL4-μ-Alvimopan
36.84Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
36.84Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
36.84Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
36.84Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
36.84Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
36.84Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
36.84Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
36.84Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
36.84Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
36.84Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.84Consensuscck_offOrthosteric Ligandccka_off
36.84Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
36.84Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
36.84Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
36.84Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
36.36Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.36Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
36.36Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.36Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.36Single7EZCUKA7EZC-A2A-UKA
36.36Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.36Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
36.36Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
36.36Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
36.36Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
36.36Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
36.36Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
36.36Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
36.36Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.36Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.36Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
36.36Consensuschemerin_onOrthosteric Ligandcml1_on
36.36Consensusendothelin_offOrthosteric Ligandetb_off
36.36Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
36.00Single5WF5UK-4320975WF5-A2A-UK-432097
36.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
36.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
36.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
36.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
36.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
36.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
36.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
36.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
36.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
36.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
36.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
36.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
35.71Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
35.71Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
35.48Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
35.29Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
35.29Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
35.29Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
35.29Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
35.29Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
35.29Consensusgq_nucleotideOrthosteric Ligandgq_p2y
35.29Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
35.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.00Single5WQCEMPA5WQC-OX2-EMPA
35.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
35.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
35.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
35.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
35.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
35.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
35.00Single7W41PD1762527W41-BB2-PD176252
35.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
35.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
35.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
35.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
35.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
35.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
35.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
35.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
35.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.00Consensusbombesin_offOrthosteric Ligandbb2_off
35.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
35.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
34.78Single4UG2CGS216804UG2-A2A-CGS21680
34.78Single5WF6UK-4320975WF6-A2A-UK-432097
34.78Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.78Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
34.78Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
34.78Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
34.78Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
34.78Single8XQJJN2418XQJ-Apelin-JN241
34.78Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
34.78Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.78Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
34.78Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.62Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
34.62Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.62Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
34.48Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
34.48Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
34.48Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
34.38Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
33.33Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4IARErgotamine4IAR-5-HT1B-Ergotamine
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
33.33Single6OS1TRV0266OS1-AT1-TRV026
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7F8YDevazepide7F8Y-CCKA-Devazepide
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
33.33Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
33.33Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
33.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
33.33Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
33.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
33.33Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
33.33Single8E0GBU728E0G-μ-BU72
33.33Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
33.33Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
33.33Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
33.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8PWNTheophylline8PWN-A2A-Theophylline
33.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8XVLZibotentan8XVL-ETA-Zibotentan
33.33Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
33.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
33.33Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
33.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
33.33Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
33.33Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensussomatostatin_offOrthosteric Ligandsst2_off
32.35Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.35Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
32.26Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
32.26Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
32.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
32.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
32.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.00Single7SK5CXCL127SK5-ACKR3-CXCL12
32.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
32.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
32.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
32.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
32.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
32.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
31.82Single4RWADIPP-NH24RWA-δ-DIPP-NH2
31.82Single6MXTSalmeterol6MXT-β2-Salmeterol
31.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
31.82Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
31.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
31.82Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
31.82Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.82Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
31.82Single7YITNalfurafine7YIT-κ-Nalfurafine
31.82Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
31.82Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
31.82Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
31.82Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.82Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.82Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.82Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.82Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
31.82Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
31.82Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.82Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
31.82Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
31.82Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.82Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Single2YDOAdenosine2YDO-A2A-Adenosine
31.58Single3REYXAC3REY-A2A-XAC
31.58Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
31.58Single4ZJCSB-6740424ZJC-OX1-SB-674042
31.58Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
31.58Single6AQFZM-2413856AQF-A2A-ZM-241385
31.58Single6IQLL7458706IQL-D4-L745870
31.58Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.58Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.58Single6TPGEMPA6TPG-OX2-EMPA
31.58Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
31.58Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Single7T32ZM-2413857T32-A2A-ZM-241385
31.58Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.58Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
31.58Single8K5CAcipimox8K5C-HCA2-Acipimox
31.58Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.58Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.58Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.58Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
31.58Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
31.58Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Consensusgrh_offOrthosteric Ligandgnrh1_off
31.25Single3OE8IT1t3OE8-CXCR4-IT1t
31.25Single3RFMCaffeine3RFM-A2A-Caffeine
31.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
30.77Single3OE0CVX153OE0-CXCR4-CVX15
30.77Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
30.77Single6PT2KGCHM076PT2-δ-KGCHM07
30.77Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
30.77Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.77Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
30.77Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.77Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
30.43Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.43Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
30.43Single5X93K-87945X93-ETB-K-8794
30.43Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
30.43Single6IBLArformoterol6IBL-β1-Arformoterol
30.43Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
30.43Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
30.43Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
30.43Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
30.43Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
30.43Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
30.43Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
30.43Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
30.43Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
30.43Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.43Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
30.43Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
30.43Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.43Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.43Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.00Single2Y02Carmoterol2Y02-β1-Carmoterol
30.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
30.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
30.00Single4YAYZD-71554YAY-AT1-ZD-7155
30.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.00Single6PS1Timolol6PS1-β2-Timolol
30.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
30.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
30.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
30.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
30.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
30.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
30.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
30.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
30.00Single7V3ZCP559407V3Z-CB1-CP55940
30.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
30.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
30.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
30.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
30.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
30.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
30.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
30.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
30.00Consensusa3_onOrthosteric Liganda3a_on
30.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
30.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
30.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
29.63Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.63Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.63Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.63Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.63Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
29.63Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.63Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.63Consensusvasop-oxy_onOrthosteric Ligandv2_on
29.63Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
29.41Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
29.41Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
29.17Single3NY9ICI118-5513NY9-β2-ICI118-551
29.17Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
29.17Single5ZTYAM102575ZTY-CB2-AM10257
29.17Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
29.17Single6KNMJN241-96KNM-Apelin-JN241-9
29.17Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.17Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
29.17Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
29.17Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
29.17Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.17Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
29.17Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
29.17Consensuskisspeptin_onOrthosteric Ligandkiss1_on
29.17Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
29.17Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
28.57Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
28.57Single5C1MBU725C1M-μ-BU72
28.57Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
28.57Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
28.57Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
28.57Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
28.57Single6TP6Filorexant6TP6-OX1-Filorexant
28.57Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
28.57Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7SINNPS-21437SIN-CaS-NPS-2143
28.57Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
28.57Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
28.57Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
28.57Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
28.57Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
28.57Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
28.57Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
28.57Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
28.57Single8JXSPF-61428JXS-D1-PF-6142
28.57Single8QOTNanobody-E8QOT-μ-Nanobody-E
28.57Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
28.57Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
28.57Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
28.57Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
28.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
28.57Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
28.57Consensusa3_on_gpOrthosteric Liganda3a_on_gp
28.57Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
28.57Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
28.57Consensusblt_offOrthosteric Ligandblt1_off
28.57Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
28.57Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.57Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
28.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
28.57Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
28.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
28.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
28.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
28.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
28.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
28.00Single8WKYPG-9348WKY-MC4-PG-934
28.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.78Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
27.78Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
27.78Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
27.78Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.78Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
27.78Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
27.78Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
27.78Single8K5BNiacin8K5B-HCA2-Niacin
27.78Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
27.78Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
27.78Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
27.59Single6FJ3PTH6FJ3-PTH1-PTH
27.59Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
27.59Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
27.50Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.27Single2YDVNECA2YDV-A2A-NECA
27.27Single3P0GBI1671073P0G-β2-BI167107
27.27Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
27.27Single4BV0Neurotensin4BV0-NTS1-Neurotensin
27.27Single4UHRCGS216804UHR-A2A-CGS21680
27.27Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
27.27Single5G53NECA5G53-A2A-NECA-Gs
27.27Single5XRAAM115425XRA-CB1-AM11542
27.27Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
27.27Single6H7JIsoprenaline6H7J-β1-Isoprenaline
27.27Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
27.27Single6TQ7SB-3348676TQ7-OX1-SB-334867
27.27Single6WGTLSD6WGT-5-HT2A-LSD
27.27Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
27.27Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Single7FEECP559407FEE-CB1-CP55940-ZCZ011
27.27Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
27.27Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
27.27Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
27.27Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
27.27Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
27.27Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
27.27Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
27.27Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
27.27Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
27.27Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
27.27Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
27.27Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
27.27Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
27.27Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
27.27Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
27.27Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
27.27Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
27.27Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
27.27Consensusa2_onOrthosteric Liganda2b_on
27.27Consensusa2_on_gpOrthosteric Liganda2b_on_gp
27.27Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
27.27Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
27.27Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.27Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
27.27Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
27.27Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
27.27Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.27Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.27Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
27.27Consensuslpa_onOrthosteric Ligandlpa1_on
27.27Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
27.27Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
27.27Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
27.27Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
27.27Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.92Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
26.92Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.92Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
26.92Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
26.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
26.67Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
26.32Single4BWBNeurotensin4BWB-NTS1-Neurotensin
26.32Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.32Single5ZKQABT-4915ZKQ-PAF-ABT-491
26.32Single6AKXA4R6AKX-CCR5-A4R
26.32Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
26.32Single6TODEMPA6TOD-OX1-EMPA-Na
26.32Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
26.32Single7BR3Elagolix7BR3-GnRH1-Elagolix
26.32Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
26.32Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.32Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
26.32Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
26.32Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
26.32Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
26.32Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
26.32Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
26.32Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
26.32Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
26.32Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
26.32Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
26.32Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
26.32Single8Y0HVUF114188Y0H-CXCR3-VUF11418
26.32Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
26.32Consensusalpha2_offOrthosteric Ligandalpha2c_off
26.32Consensusangiotensin_offOrthosteric Ligandat1_off
26.32Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
26.32Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
26.32Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.32Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
26.09Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
26.09Single4AMIBucindolol4AMI-β1-Bucindolol
26.09Single4LDEBI1671074LDE-β2-BI167107
26.09Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
26.09Single6A93Risperidone6A93-5-HT2A-Risperidone
26.09Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
26.09Single6KQICP559406KQI-CB1-CP55940-Org27569
26.09Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.09Single6ZG4HTL00099366ZG4-M1-HTL0009936
26.09Single7DFPSpiperone7DFP-D2-Spiperone
26.09Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
26.09Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
26.09Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
26.09Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.09Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.09Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
26.09Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
26.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
26.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
26.09Single8JJ8Formoterol8JJ8-β2-Formoterol
26.09Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
26.09Single8JWY2-1188JWY-A2A-2-118
26.09Single8JWZAB9288JWZ-A2A-AB928-Na
26.09Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
26.09Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.09Single8XQJJN2418XQJ-Apelin-JN241
26.09Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
26.09Single8XYIVUF106618XYI-CXCR3-VUF10661
26.09Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.09Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.09Consensusalpha1_offOrthosteric Ligandalpha1a_off
26.09Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
26.09Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
26.09Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
26.09Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
26.09Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
26.09Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
26.09Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.09Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.09Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.09Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single6W25SHU91196W25-MC4-SHU9119-Ca
25.93Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.93Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.93Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.81Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.81Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
25.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
25.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
25.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
25.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
25.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
25.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.00Single6H7LDobutamine6H7L-β1-Dobutamine
25.00Single6KUXRS-799486KUX-α2a-RS-79948
25.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
25.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
25.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
25.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
25.00Single6PS4ICI118-5516PS4-β2-ICI118-551
25.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
25.00Single6ZINSR486926ZIN-NTS1-SR48692
25.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
25.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
25.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
25.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
25.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
25.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
25.00Single7UL3Famotidine7UL3-H2-Famotidine
25.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
25.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
25.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
25.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
25.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
25.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
25.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
25.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
25.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
25.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
25.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
25.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
25.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
25.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
25.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
25.00Single8XVUCXCL28XVU-CXCR2-CXCL2
25.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
25.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
25.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
25.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
25.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
25.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
25.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
25.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensusvasop-oxy_offOrthosteric Ligandot_off
24.24Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
24.14Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
24.14Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
24.14Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
24.00Single5EE7MK08935EE7-Glucagon-MK0893
24.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
24.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
24.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
24.00Single8X5YAstemizole8X5Y-H1-Astemizole
24.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
24.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
24.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
23.81Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
23.81Single2Y04Salbutamol2Y04-β1-Salbutamol
23.81Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
23.81Single3NY8ICI118-5513NY8-β2-ICI118-551
23.81Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
23.81Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
23.81Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
23.81Single4GBRS-Carazolol4GBR-β2-S-Carazolol
23.81Single4QKX35V4QKX-β2-35V
23.81Single5DHGC-355DHG-NOP-C-35
23.81Single5DHHSB-6121115DHH-NOP-SB-612111
23.81Single5T04Neurotensin5T04-NTS1-Neurotensin
23.81Single5TGZAM65385TGZ-CB1-AM6538
23.81Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.81Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.81Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
23.81Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
23.81Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
23.81Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
23.81Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
23.81Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.81Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
23.81Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
23.81Single7BU7BI1671077BU7-β1-BI167107
23.81Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
23.81Single7F83PF-051904577F83-Ghrelin-PF-05190457
23.81Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
23.81Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
23.81Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
23.81Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
23.81Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
23.81Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
23.81Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.81Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
23.81Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
23.81Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
23.81Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
23.81Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
23.81Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
23.81Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
23.81Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
23.81Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
23.81Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
23.81Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
23.81Single8JJOAlprenolol8JJO-β2-Alprenolol
23.81Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.81Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
23.81Single8RLNLUF58348RLN-A2A-LUF5834
23.81Single8T1WCVN4248T1W-GPR6-CVN424
23.81Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
23.81Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
23.81Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.81Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
23.81Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.81Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
23.81Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
23.81Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.81Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
23.81Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
23.81Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
23.81Consensusdopamine_offOrthosteric Ligandd2_off d3_off
23.81Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
23.81Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
23.53Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.53Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
23.33Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
23.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
23.33Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
23.08Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
23.08Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
23.08Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
23.08Single8IEBA1LYA8IEB-GPR156-A1LYA
23.08Single8KIGSHU91198KIG-MC3-SHU9119-Ca
23.08Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
23.08Single8XWNCXCL88XWN-CXCR2-CXCL8
22.86Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
22.86Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
22.73Single2RH1S-Carazolol2RH1-β2-S-Carazolol
22.73Single2Y00Dobutamine2Y00-β1-Dobutamine
22.73Single2Y03Isoprenaline2Y03-β1-Isoprenaline
22.73Single2YCWS-Carazolol2YCW-β1-S-Carazolol
22.73Single5D6LS-Carazolol5D6L-β2-S-Carazolol
22.73Single5JQHS-Carazolol5JQH-β2-S-Carazolol
22.73Single5TVNLSD5TVN-5-HT2B-LSD
22.73Single5WIUNemonapride5WIU-D4-Nemonapride
22.73Single5WIVNemonapride5WIV-D4-Nemonapride-Na
22.73Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
22.73Single5XPRBosentan5XPR-ETB-Bosentan
22.73Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
22.73Single6E67BI1671076E67-β2-BI167107-Gs (fused)
22.73Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.73Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
22.73Single6LUQHaloperidol6LUQ-D2-Haloperidol
22.73Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
22.73Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
22.73Single6PS6Timolol6PS6-β2-Timolol
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.73Single6Z4SSR486926Z4S-NTS1-SR48692
22.73Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
22.73Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
22.73Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.73Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
22.73Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
22.73Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
22.73Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
22.73Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
22.73Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
22.73Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
22.73Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.73Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
22.73Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
22.73Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.73Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.73Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
22.73Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
22.73Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
22.73Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
22.73Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
22.73Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
22.73Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
22.73Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
22.73Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
22.73Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
22.73Consensusamine_offonOrthosteric Ligandamine_off amine_on
22.73Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
22.73Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
22.73Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
22.73Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
22.73Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
22.73Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
22.73Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
22.73Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.73Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
22.73Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.73Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Consensustrace-amine_onOrthosteric Ligandta1_on
22.58Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.58Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
22.58Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
22.58Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
22.22Single3UZAGTPL92363UZA-A2A-GTPL9236
22.22Single4XNWMRS25004XNW-P2Y1-MRS2500
22.22Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
22.22Single6HLOAprepitant6HLO-NK1-Aprepitant
22.22Single6ME5Agomelatine6ME5-MT1-Agomelatine
22.22Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
22.22Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
22.22Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
22.22Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
22.22Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.22Single7WC5Psilocin7WC5-5-HT2A-Psilocin
22.22Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.22Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
22.22Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
22.22Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
22.22Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.22Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
22.22Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
22.22Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
22.22Consensus5ht2_onOrthosteric Ligand5ht2b_on
22.22Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
21.88Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
21.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.88Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.88Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
21.88Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
21.88Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.88Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.88Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.74Single4DJHJDTic4DJH-κ-JDTic
21.74Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
21.74Single5D5AS-Carazolol5D5A-β2-S-Carazolol
21.74Single5D5BS-Carazolol5D5B-β2-S-Carazolol
21.74Single5TZRMK86665TZR-FFA1-MK8666
21.74Single5V56TC1145V56-SMO-TC114
21.74Single5XR8AM8415XR8-CB1-AM841
21.74Single6J20Aprepitant6J20-NK1-Aprepitant
21.74Single6J21Aprepitant6J21-NK1-Aprepitant
21.74Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
21.74Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.74Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
21.74Single7F1TMIP-1a7F1T-CCR5-MIP-1a
21.74Single7R0CAVP7R0C-V2-AVP-Arrestin2
21.74Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
21.74Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
21.74Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
21.74Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
21.74Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
21.74Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
21.74Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
21.74Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
21.74Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
21.74Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.74Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.74Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
21.74Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
21.74Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
21.74Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
21.74Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
21.74Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
21.74Single9BJKNAM9BJK-μ-Naloxone-NAM
21.74Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
21.74Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
21.74Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
21.74Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.74Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.74Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
21.74Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.74Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.74Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.43Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
21.43Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.05Single3PBLEticlopride3PBL-D3-Eticlopride
21.05Single6HLLCP999946HLL-NK1-CP99994
21.05Single6TP4ACT-4622066TP4-OX1-ACT-462206
21.05Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
21.05Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
21.05Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.05Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
21.05Single7SRQLSD7SRQ-5-HT2B-LSD
21.05Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
21.05Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.05Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
21.05Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
21.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
21.05Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
21.05Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
21.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
21.05Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
21.05Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.05Single9B9Y7DY9B9Y-CB1-7DY
21.05Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.05Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.05Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
21.05Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
20.83Single3D4STimolol3D4S-β2-Timolol
20.83Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
20.83Single4N4WSANT-14N4W-SMO-SANT-1
20.83Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.83Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
20.83Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
20.83Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.83Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.83Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
20.83Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.83Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.83Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.83Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
20.83Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
20.83Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.83Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.83Single8XWACXCL18XWA-CXCR2-CXCL1
20.83Single8XWMCXCL68XWM-CXCR2-CXCL6
20.83Single8XWSCXCL58XWS-CXCR2-CXCL5
20.83Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.83Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
20.83Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
20.83Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
20.69Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
20.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.69Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.69Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
20.59Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
20.59Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
20.59Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
20.59Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
20.00Single6B73MP11046B73-κ-MP1104
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
20.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
20.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
20.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
20.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
20.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
20.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
20.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
20.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
20.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
20.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
20.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
20.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
20.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
20.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
20.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
20.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
20.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
20.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
20.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
20.00Single8IWESpermidine8IWE-TA9-Spermidine
20.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.00Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
20.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XWFCXCL38XWF-CXCR2-CXCL3
20.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
20.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
20.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
20.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
20.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
19.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
19.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
19.44Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.35Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
19.35Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
19.35Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
19.35Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
19.35Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
19.23Single6PT3DPI-2876PT3-δ-DPI-287
19.23Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
19.23Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
19.23Single7SK9CCX6627SK9-ACKR3-CCX662
19.23Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
19.05Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
19.05Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
19.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
19.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
19.05Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
19.05Single6TPNHTL66416TPN-OX2-HTL6641
19.05Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
19.05Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
19.05Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
19.05Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
19.05Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
19.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
19.05Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
19.05Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
19.05Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
19.05Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
19.05Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.05Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
19.05Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
19.05Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
19.05Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
19.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
19.05Single8K2WAMG4878K2W-CXCR3-AMG487
19.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
19.05Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
19.05Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
19.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
19.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
19.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
19.05Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
19.05Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
19.05Consensusalpha1_onOrthosteric Ligandalpha1a_on
19.05Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
19.05Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
19.05Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
19.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
19.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
19.05Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
19.05Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
18.92Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.75Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
18.75Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.75Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
18.75Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
18.75Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
18.75Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
18.75Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.75Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7QA8Peptide7QA8-STE2-Peptide
18.52Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.52Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.52Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8IEIA1LYA8IEI-GPR156-A1LYA
18.52Single8IEPA1LYA8IEP-GPR156-A1LYA
18.52Single8IEPA1LYA8IEP-GPR156-A1LYA
18.52Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.52Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.52Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.18Single2Y01Dobutamine2Y01-β1-Dobutamine
18.18Single4EJ4Naltrindole4EJ4-δ-Naltrindole
18.18Single4QIMANTA XV4QIM-SMO-ANTA XV
18.18Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
18.18Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
18.18Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.18Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
18.18Single6GPSMK08126GPS-CCR2-MK0812
18.18Single6H7MSalbutamol6H7M-β1-Salbutamol
18.18Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.18Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
18.18Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
18.18Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
18.18Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
18.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
18.18Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
18.18Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
18.18Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
18.18Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
18.18Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
18.18Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.18Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.18Single7WC7Lisuride7WC7-5-HT2A-Lisuride
18.18Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.18Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
18.18Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
18.18Single7YXAONO-54306087YXA-S1P5-ONO-5430608
18.18Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.18Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
18.18Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
18.18Single8JXRLSD8JXR-D1-LSD
18.18Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
18.18Single8X63Mepyramine8X63-H1-Mepyramine
18.18Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
18.18Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
18.18Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
18.18Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.18Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
18.18Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
18.18Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
18.18Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
18.18Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
18.18Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
18.18Consensusalpha2_onOrthosteric Ligandalpha2b_on
18.18Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
18.18Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.18Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
18.18Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
18.18Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
18.18Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
18.18Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
18.18Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
18.18Consensushistamine_offOrthosteric Ligandh1_off
18.18Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.86Single8IEBA1LYA8IEB-GPR156-A1LYA
17.65Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
17.65Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
17.65Single7WC4Serotonin7WC4-5-HT2A-Serotonin
17.65Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
17.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
17.39Single4JKVTaladegib4JKV-SMO-Taladegib
17.39Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
17.39Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
17.39Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
17.39Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
17.39Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
17.39Single6GPXMK08126GPX-CCR2-MK0812
17.39Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.39Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
17.39Single7C4SS1P7C4S-S1P3-S1P
17.39Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.39Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
17.39Single7WC6LSD7WC6-5-HT2A-LSD
17.39Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.39Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.39Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
17.39Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
17.39Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
17.39Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
17.39Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
17.39Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
17.39Consensusep_offOrthosteric Ligandep4_off
17.39Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
17.24Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
17.14Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
17.07Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
16.67Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
16.67Single5V57TC1145V57-SMO-TC114
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single6E59L-7607356E59-NK1-L-760735
16.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
16.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
16.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
16.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
16.67Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
16.67Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
16.67Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
16.67Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
16.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
16.67Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
16.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
16.67Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
16.67Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
16.67Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
16.67Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
16.67Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
16.67Consensussensory_onOrthosteric Ligandopsins_on
16.67Consensustachykinin_offOrthosteric Ligandnk1_off
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.13Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.13Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
16.13Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.13Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
16.00Single5X33BIIL2605X33-BLT1-BIIL260
16.00Single6CM4Risperidone6CM4-D2-Risperidone
16.00Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
16.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
16.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
16.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
16.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
16.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
15.79Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
15.79Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.79Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
15.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
15.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
15.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
15.79Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
15.79Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
15.79Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
15.79Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
15.79Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.79Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
15.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.79Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.79Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
15.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
15.79Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.79Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.79Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
15.79Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
15.79Consensusgi_sensoryOrthosteric Ligandgi_opsins
15.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
15.79Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
15.79Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
15.79Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
15.79Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
15.62Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.62Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.62Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.38Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
15.38Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
15.38Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
15.38Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
15.38Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.38Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
15.38Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.15Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.15Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
15.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
15.00Single5L7IVismodegib5L7I-SMO-Vismodegib
15.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
15.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
15.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
15.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
15.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
15.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
15.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
15.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
15.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
15.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
15.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
15.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
15.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
15.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
15.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
14.81Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
14.81Single8IEIA1LYA8IEI-GPR156-A1LYA
14.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
14.71Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
14.71Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.29Single4QINSAG1.54QIN-SMO-SAG1.5
14.29Single5U09Taranabant5U09-CB1-Taranabant
14.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
14.29Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
14.29Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.29Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
14.29Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
14.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
14.29Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
14.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
14.29Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
14.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
14.29Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
14.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
14.29Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
14.29Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
14.29Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
14.29Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
14.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
14.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
14.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
14.29Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
14.29Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.89Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
13.79Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.64Single3RZECidoxepin3RZE-H1-Cidoxepin
13.64Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
13.64Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.64Single6A94Zotepine6A94-5-HT2A-Zotepine
13.64Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.64Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.64Single6VI4JDTic6VI4-κ-JDTic
13.64Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.64Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
13.64Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.64Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
13.64Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
13.64Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
13.64Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
13.64Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.64Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.64Single7VODCariprazine7VOD-5-HT2A-Cariprazine
13.64Single7VV6C48/807VV6-MRGPRX2-C48/80
13.64Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.64Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
13.64Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
13.64Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
13.64Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
13.64Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
13.64Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.64Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
13.64Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
13.64Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
13.64Single9BJKNaloxone9BJK-μ-Naloxone-NAM
13.64Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
13.64Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.64Consensussensory_offOrthosteric Ligandopsins_off
13.51Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
13.33Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.16Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.16Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.04Single4DAJTiotropium4DAJ-M3-Tiotropium
13.04Single4MQSIperoxo4MQS-M2-Iperoxo
13.04Single4U14Tiotropium4U14-M3-Tiotropium
13.04Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
13.04Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
13.04Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
13.04Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
13.04Single6IIVDaltroban6IIV-TP-Daltroban
13.04Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
13.04Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.04Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
13.04Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
13.04Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.04Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
13.04Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
13.04Single8X64Desloratadine8X64-H1-Desloratadine
13.04Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.04Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.04Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.04Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
13.04Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
13.04Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
13.04Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.90Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.90Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
12.50Single4NTJAZD12834NTJ-P2Y12-AZD1283
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single6HLPNetupitant6HLP-NK1-Netupitant
12.50Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
12.50Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.50Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.50Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
12.50Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.50Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
12.50Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.50Single8ZMFA1L108ZMF-5-HT2C-A1L10
12.50Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
12.50Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.50Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.50Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single4U15Tiotropium4U15-M3-Tiotropium
12.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
12.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Single6OL9Tiotropium6OL9-M5-Tiotropium
12.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
12.00Single8EA0Iperoxo8EA0-M3-Iperoxo
12.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
12.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
12.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.00Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.76Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
11.76Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.54Single5CXVTiotropium5CXV-M1-Tiotropium
11.54Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
11.54Single6IIURamatroban6IIU-TP-Ramatroban
11.54Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
11.54Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
11.54Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.54Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.54Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
11.54Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.54Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
11.54Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.43Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
11.11Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
11.11Single5CGDHTL142425CGD-mGlu5-HTL14242
11.11Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
11.11Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.11Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.11Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8XVJMacitentan8XVJ-ETA-Macitentan
11.11Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
11.11Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
11.11Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
11.11Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
10.71Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.53Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
10.53Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.53Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
10.53Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.53Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
9.52Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.52Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.52Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.52Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.52Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
9.52Single6LI0C176LI0-GPR52-C17
9.52Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
9.52Single7UL2SR486927UL2-NTS1-SR48692-Na
9.52Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
9.52Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
9.52Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.52Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.52Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.52Consensusneurotensin_offOrthosteric Ligandnts1_off
9.52Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.09Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.09Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.09Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
9.09Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
9.09Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
9.09Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.09Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.09Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.09Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
9.09Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.09Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.09Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.09Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.70Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.70Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.70Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.70Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.70Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
8.70Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.70Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
8.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.33Single5DSGTiotropium5DSG-M4-Tiotropium
8.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
8.33Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
8.33Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
8.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.33Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.33Consensusblt_onOrthosteric Ligandblt1_on
8.33Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
8.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
8.33Consensusleukotriene_onOrthosteric Ligandblt_on
8.33Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
8.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
8.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
8.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
8.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
7.69Single7P2L4YI7P2L-mGlu5-4YI
7.69Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
7.69Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
7.69Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.69Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
7.69Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
7.14Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.90Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.90Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.56Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.26Single8HS2Fab0468HS2-GPR20-Fab046
5.26Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.26Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
5.00Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.76Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.76Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.76Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.76Single8JPSCCL78JPS-ACKR1-CCL7
4.55Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
4.55Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
4.55Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
4.17Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.00Single6FFHFenobam6FFH-mGlu5-Fenobam
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.70Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB

Consensus Members
Id Members
8HK2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8IA8 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
Net Summary
Imin 2.425
Number of Linked Nodes 875
Number of Links 1119
Number of Hubs 198
Number of Links mediated by Hubs 727
Number of Communities 20
Number of Nodes involved in Communities 295
Number of Links involved in Communities 452
Path Summary
Number Of Nodes in MetaPath 141
Number Of Links MetaPath 140
Number of Shortest Paths 1905545
Length Of Smallest Path 3
Average Path Length 23.7129
Length of Longest Path 52
Minimum Path Strength 0.605
Average Path Strength 5.38953
Maximum Path Strength 20.31
Minimum Path Correlation 0.7
Average Path Correlation 0.984157
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 48.9827
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.0243
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
compl-peptide_on_gpc5a1_on_gp
c3a_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download c3a_on_gp.zip



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