Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x50 5.07017509
2I1x50 4.35825548
32x42 4.6385508
42x50 6.01258519
52x56 5.03146418
6E1x50 4.94173758
73x28 4.255505
83x43 5.23656418
93x49 6.20219439
103x50 4.39583419
113x52 3.91052405
123x56 3.3624406
13I2x53 5.25986637
14E2 8.67727924
155x39 6.65875428
165x47 9.02567518
175x58 5.28609
186x44 4.49208519
196x48 7.26054718
206x49 4.18396407
216x51 7.38408517
226x52 7.79033517
23E3 4.99567563
247x42 6.88244717
257x49 6.06708419
267x53 5.62385419
278x50 5.37042548
28Lig 8.64221110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x39 7x39 14.42294.85042NoNo076
27x39 7x42 21.15646.955NoYes067
32x57 7x42 10.32337.09625NoYes087
47x42 Lig 65.87798.55708YesYes170
56x48 Lig 92.93095.30042YesYes180
66x48 7x45 19.38069.8875YesNo089
77x45 7x49 16.23267.60583NoYes099
82x50 7x49 29.62325.105YesYes199
91x50 2x50 31.02948.695YesYes099
101x46 1x50 10.55271.97708NoYes089
116x44 6x48 83.09614.55167YesYes198
125x54 6x44 1004.63375NoYes089
133x47 5x54 99.75364.25458NoNo098
143x47 5x57 98.1353.93792NoNo096
153x51 5x57 97.21748.80625NoNo086
163x51 3x55 93.389711.3296NoNo087
173x55 3x56 92.5743.69292NoYes076
183x52 3x56 88.36824.83042YesYes056
193x52 I2x53 85.67484.98708YesYes057
203x49 I2x53 45.4318.19208YesYes397
212x39 3x49 34.11364.8325NoYes389
222x37 2x39 65.35962.99042NoNo078
232x37 2x40 62.91695.55333NoNo078
242x40 I1x50 19.86495.02375NoYes488
25I2x53 I2x57 33.854511.1362YesNo376
262x39 I2x57 33.00486.61917NoNo386
272x42 3x49 12.28175.44333YesYes089
285x461 Lig 22.15472.78375NoYes060
293x37 5x461 20.83356.59417NoNo076
303x37 4x53 16.81893.67667NoNo078
313x38 4x53 15.46373.24417NoNo088
323x38 4x50 14.18.92125NoNo089
332x45 4x50 11.34714.93458NoNo099
343x43 6x44 38.21743.6575YesYes189
352x46 3x43 16.48753.80792NoYes198
362x50 7x46 10.55278.46708YesNo099
372x56 7x42 23.32723.4325YesYes187
382x56 3x28 38.36195.45125YesYes085
392x59 3x28 11.88246.02208NoYes055
402x60 7x42 21.02895.92042NoYes077
412x60 3x28 20.23454.33125NoYes075
423x28 E1x50 40.97464.0575YesYes058
43E1x49 E1x50 17.47741.43583NoYes048
442x66 E1x49 10.51026.84417NoNo054
455x43 Lig 19.55054.95667NoYes070
465x39 5x43 18.62447.68458YesNo087
475x39 E2 13.18667.07375YesYes284
483x43 7x53 21.55577.47208YesYes189
493x47 5x58 28.845710.0971NoYes099
506x52 Lig 14.22325.95125YesYes170
515x47 6x52 17.001618.1267YesYes187
525x47 6x49 22.40965.62375YesYes087
537x52 7x53 11.97594.78542NoYes089
546x43 7x52 10.48054.13125NoNo078
556x49 6x53 10.81614.87375YesNo076
562x40 8x50 40.54124.11458NoYes488
578x47 8x50 17.04835.99542NoYes088
588x47 8x49 15.16632.87292NoNo087
593x50 7x53 16.44084.97083YesYes199
603x50 7x56 10.01321.81125YesNo097
615x58 5x61 12.82.4575YesNo099
623x54 5x61 11.30462.045NoNo089
633x54 5x64 10.05572.87875NoNo086
647x54 8x50 19.98397.3525NoYes078
657x54 8x54 16.16474.125NoNo077
661x52 8x54 10.40836.445NoNo077
673x24 E1x52 11.93762.19875NoNo055
682x46 2x50 15.233.56167NoYes199
693x43 7x49 16.36016.00875YesYes189
703x32 Lig 21.844611.0379NoYes170
712x56 3x32 21.18618.98917YesNo187
723x50 5x58 12.79586.46917YesYes099
735x47 6x44 18.27185.35917YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x328.989171YesNo8721
2x567x423.43251YesYes8721
2x577x427.096250NoYes8721
2x607x425.920420NoYes7721
3x327x428.094171NoYes7711
3x32Lig11.03791NoYes7010
3x33Lig10.81460NoYes6010
3x366x485.004171NoYes6811
3x36Lig8.545831NoYes6010
3x375x4616.594170NoNo7621
3x406x4811.10790NoYes8821
5x395x437.684582YesNo8721
5x406x556.82750NoNo6721
5x43Lig4.956670NoYes7010
5x476x445.359171YesYes8922
5x476x5218.12671YesYes8721
6x446x484.551671YesYes9821
6x486x526.47251YesYes8711
6x487x418.499581YesNo8712
6x487x459.88751YesNo8912
6x48Lig5.300421YesYes8010
6x516x525.271YesYes7711
6x516x556.51YesNo7711
6x517x385.492081YesNo7611
6x51Lig16.97881YesYes7010
6x52Lig5.951251YesYes7010
6x55Lig4.625421NoYes7010
7x387x428.121671NoYes6711
7x38Lig15.51251NoYes6010
7x397x426.9550NoYes6721
7x42Lig8.557081YesYes7010
5x446x523.131250NoYes7721
3x334x573.028330NoNo6812
5x461Lig2.783750NoYes6010
6x517x342.679581YesNo7412

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
91.67Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
91.67Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
91.67Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
91.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
90.91Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
90.91Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
90.91Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
90.91Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
90.91Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
90.91Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
90.91Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
90.91Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
90.91Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
84.62Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
84.62Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
84.62Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
84.62Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
84.62Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
84.62Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
84.62Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
84.62Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
84.62Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
84.62Consensushistamine_offOrthosteric Ligandh1_off
83.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
83.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
83.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
83.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
83.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
83.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
83.33Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
83.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
83.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
83.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
83.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
83.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
83.33Single8GGNEpinephrine8GGN-β2-Epinephrine
83.33Single8GGOEpinephrine8GGO-β2-Epinephrine
83.33Single8GGUEpinephrine8GGU-β2-Epinephrine
83.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
83.33Single8JJOAlprenolol8JJO-β2-Alprenolol
83.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
83.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
83.33Single8X64Desloratadine8X64-H1-Desloratadine
83.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
83.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
83.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
83.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
83.33Consensustar_onOrthosteric Ligandta1_on
81.82Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
81.82Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
81.82Consensusalpha1_onOrthosteric Ligandalpha1a_on
81.82Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
78.57Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
78.57Single4AMIBucindolol4AMI-β1-Bucindolol
78.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
78.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
78.57Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
76.92Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
76.92Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
76.92Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
76.92Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
76.92Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
76.92Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
76.92Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
76.92Single7WC6LSD7WC6-5-HT2A-LSD
76.92Single7XKAEpinephrine7XKA-β2-Epinephrine
76.92Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
76.92Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
76.92Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
76.92Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
76.92Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
76.92Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
76.92Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
75.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
75.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
75.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
75.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
75.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
75.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
75.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGIEpinephrine8GGI-β2-Epinephrine
75.00Single8GGKEpinephrine8GGK-β2-Epinephrine
75.00Single8GGMEpinephrine8GGM-β2-Epinephrine
75.00Single8GGPEpinephrine8GGP-β2-Epinephrine
75.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
75.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
75.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
75.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
73.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
73.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
73.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
73.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
73.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
73.33Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
72.73Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
72.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
72.73Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
72.73Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Single2YDVNECA2YDV-A2A-NECA
71.43Single4U15Tiotropium4U15-M3-Tiotropium
71.43Single4UHRCGS216804UHR-A2A-CGS21680
71.43Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
71.43Single5G53NECA5G53-A2A-NECA-Gs
71.43Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
71.43Single6H7JIsoprenaline6H7J-β1-Isoprenaline
71.43Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
71.43Single6OL9Tiotropium6OL9-M5-Tiotropium
71.43Single6TQ7SB-3348676TQ7-OX1-SB-334867
71.43Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
71.43Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
71.43Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
71.43Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
71.43Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
71.43Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
71.43Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
71.43Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
69.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
69.23Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
69.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
69.23Single4EJ4Naltrindole4EJ4-δ-Naltrindole
69.23Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
69.23Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
69.23Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
69.23Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
69.23Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
69.23Single6H7MSalbutamol6H7M-β1-Salbutamol
69.23Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
69.23Single6PS1Timolol6PS1-β2-Timolol
69.23Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
69.23Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
69.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
69.23Single7WC7Lisuride7WC7-5-HT2A-Lisuride
69.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
69.23Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
69.23Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
69.23Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Single8X63Mepyramine8X63-H1-Mepyramine
69.23Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
69.23Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
69.23Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
69.23Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
69.23Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
69.23Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
69.23Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
69.23Consensushistamine_onOrthosteric Ligandh1_on h4_on
68.75Single3NY9PubChem 9131033NY9-β2-PubChem 913103
68.75Single8X5YAstemizole8X5Y-H1-Astemizole
66.67Single4LDEBI1671074LDE-β2-BI167107
66.67Single5CXVTiotropium5CXV-M1-Tiotropium
66.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
66.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
66.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
66.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
66.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
66.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
66.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
66.67Single7YITNalfurafine7YIT-κ-Nalfurafine
66.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
66.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
66.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
66.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGVEpinephrine8GGV-β2-Epinephrine
66.67Single8GGWEpinephrine8GGW-β2-Epinephrine
66.67Single8GGXEpinephrine8GGX-β2-Epinephrine
66.67Single8GH0Epinephrine8GH0-β2-Epinephrine
66.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8JJ8Formoterol8JJ8-β2-Formoterol
66.67Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
66.67Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
66.67Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
66.67Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
64.71Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
64.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
64.29Single5C1MBU725C1M-μ-BU72
64.29Single6E67BI1671076E67-β2-BI167107-Gs (fused)
64.29Single6PS6Timolol6PS6-β2-Timolol
64.29Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
64.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
64.29Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
64.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
64.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
64.29Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
64.29Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
64.29Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
64.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
63.64Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
62.50Single6H7LDobutamine6H7L-β1-Dobutamine
62.50Single6IBLArformoterol6IBL-β1-Arformoterol
62.50Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
62.50Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
62.50Consensusendothelin_offOrthosteric Ligandetb_off
62.50Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
61.54Single3RZECidoxepin3RZE-H1-Cidoxepin
61.54Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
61.54Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
61.54Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
61.54Single6A94Zotepine6A94-5-HT2A-Zotepine
61.54Single6TPGEMPA6TPG-OX2-EMPA
61.54Single6TPNHTL66416TPN-OX2-HTL6641
61.54Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
61.54Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
61.54Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
61.54Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
61.54Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
61.54Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
61.54Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
61.54Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
61.54Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGLEpinephrine8GGL-β2-Epinephrine
61.54Single8GGTEpinephrine8GGT-β2-Epinephrine
61.54Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
61.54Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
61.54Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
61.54Consensus5ht5_onOrthosteric Ligand5ht5a_on
61.54Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
61.54Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
60.00Single3P0GBI1671073P0G-β2-BI167107
60.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
60.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
60.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
60.00Single5X93K-87945X93-ETB-K-8794
60.00Single6J21Aprepitant6J21-NK1-Aprepitant
60.00Single6WGTLSD6WGT-5-HT2A-LSD
60.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
60.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
60.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
60.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
60.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
60.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
60.00Single8E0GBU728E0G-μ-BU72
60.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
60.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
60.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
60.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
58.82Single4UG2CGS216804UG2-A2A-CGS21680
58.82Single6PT3DPI-2876PT3-δ-DPI-287
58.82Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single3PBLEticlopride3PBL-D3-Eticlopride
58.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
58.33Single7SRQLSD7SRQ-5-HT2B-LSD
58.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
58.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
58.33Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GGSEpinephrine8GGS-β2-Epinephrine
58.33Single8GGYEpinephrine8GGY-β2-Epinephrine
58.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
58.33Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
58.33Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
58.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
58.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
57.14Single2Y02Carmoterol2Y02-β1-Carmoterol
57.14Single2Y04Salbutamol2Y04-β1-Salbutamol
57.14Single4DAJTiotropium4DAJ-M3-Tiotropium
57.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
57.14Single4MQSIperoxo4MQS-M2-Iperoxo
57.14Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
57.14Single4U14Tiotropium4U14-M3-Tiotropium
57.14Single5DSGTiotropium5DSG-M4-Tiotropium
57.14Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single7BU7BI1671077BU7-β1-BI167107
57.14Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
57.14Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
57.14Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
57.14Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
57.14Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
57.14Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
57.14Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
57.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
57.14Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
57.14Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
57.14Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
57.14Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
57.14Consensustachykinin_offOrthosteric Ligandnk1_off
56.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
56.25Single6CM4Risperidone6CM4-D2-Risperidone
56.25Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
56.25Single6HLPNetupitant6HLP-NK1-Netupitant
56.25Single6MXTSalmeterol6MXT-β2-Salmeterol
56.25Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
56.25Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
56.25Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
56.25Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
56.25Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
56.25Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
55.56Single4IARErgotamine4IAR-5-HT1B-Ergotamine
55.56Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
55.56Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
55.56Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
54.55Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
54.55Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
53.85Single6AKXA4R6AKX-CCR5-A4R
53.85Single6B73PubChem 1319551386B73-κ-PubChem 131955138
53.85Single6KUXRS-799486KUX-α2a-RS-79948
53.85Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
53.85Single6TODEMPA6TOD-OX1-EMPA-Na
53.85Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
53.85Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
53.85Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.85Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.85Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
53.85Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
53.85Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.85Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.85Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.85Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
53.85Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
53.85Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
53.85Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
53.85Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.85Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single5TVNLSD5TVN-5-HT2B-LSD
53.33Single5WIUNemonapride5WIU-D4-Nemonapride
53.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
53.33Single5WQCEMPA5WQC-OX2-EMPA
53.33Single5XPRBosentan5XPR-ETB-Bosentan
53.33Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
53.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
53.33Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
53.33Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
53.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
53.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.33Single8EA0Iperoxo8EA0-M3-Iperoxo
53.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
53.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
53.33Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
53.33Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
53.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
52.94Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
52.94Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
52.94Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
52.94Single7UM4AS26747237UM4-5-HT5A-AS2674723
52.94Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
52.94Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
52.94Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
52.63Single6HLOAprepitant6HLO-NK1-Aprepitant
52.63Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
50.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
50.00Single4DJHJDTic4DJH-κ-JDTic
50.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
50.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
50.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
50.00Single6E59L-7607356E59-NK1-L-760735
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single6J20Aprepitant6J20-NK1-Aprepitant
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Single6PT2KGCHM076PT2-δ-KGCHM07
50.00Single6VI4JDTic6VI4-κ-JDTic
50.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
50.00Single7SK9CCX6627SK9-ACKR3-CCX662
50.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
50.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
50.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
50.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
50.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
50.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
50.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
50.00Single8GGREpinephrine8GGR-β2-Epinephrine
50.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
50.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
50.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
50.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
50.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
50.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
50.00Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
50.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
47.62Single7C61Ergotamine7C61-5-HT1B-Ergotamine
47.06Single6A93Risperidone6A93-5-HT2A-Risperidone
47.06Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.06Single6ZG4HTL00099366ZG4-M1-HTL0009936
47.06Single7DFPSpiperone7DFP-D2-Spiperone
47.06Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
47.06Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
47.06Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8JJLOlodaterol8JJL-β2-Olodaterol
47.06Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
46.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
46.67Single2Y01Dobutamine2Y01-β1-Dobutamine
46.67Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
46.67Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
46.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
46.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
46.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.67Single6TOTLemborexant6TOT-OX1-Lemborexant
46.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
46.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
46.67Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
46.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
46.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
46.67Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
46.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
46.67Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
46.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
46.15Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.15Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
46.15Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.15Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
46.15Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
46.15Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
46.15Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
46.15Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8GH1Epinephrine8GH1-β2-Epinephrine
46.15Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
46.15Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
45.45Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
45.45Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
45.45Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
45.00Single3QAKUK-4320973QAK-A2A-UK-432097
45.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
44.44Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
44.44Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
44.44Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.44Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
44.44Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
44.44Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
44.44Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
44.44Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
44.44Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
43.75Single2Y00Dobutamine2Y00-β1-Dobutamine
43.75Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
43.75Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
43.75Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
43.75Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
43.75Single6TP6Filorexant6TP6-OX1-Filorexant
43.75Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
43.75Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
43.75Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
43.75Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
43.75Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
43.75Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
43.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
43.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
43.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
43.75Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
43.75Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
43.75Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
43.75Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
43.75Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
42.86Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
42.86Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
42.86Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
42.86Single5DHHSB-6121115DHH-NOP-SB-612111
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single5WS3EMPA5WS3-OX2-EMPA
42.86Single6AKYMaraviroc6AKY-CCR5-Maraviroc
42.86Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
42.86Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
42.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
42.86Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
42.86Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
42.86Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8IWESpermidine8IWE-TAAR9-Spermidine
42.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
42.86Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
42.86Consensusorexin_offOrthosteric Ligandox2_off ox1_off
42.11Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single5ZTYAM102575ZTY-CB2-AM10257
42.11Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
41.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
41.67Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
41.67Consensussensory_onOrthosteric Ligandopsin_on
41.18Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
41.18Single7EPENAM5637EPE-mGlu-NAM563
41.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
41.18Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
41.18Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.18Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
41.18Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
41.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
41.18Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
41.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
41.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
40.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
40.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
40.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
40.00Single6IQLL7458706IQL-D4-L745870
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
40.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
40.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
40.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
40.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
40.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensussensory_offOrthosteric Ligandopsin_off
38.89Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.89Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.89Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
38.89Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
38.89Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
38.89Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.89Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
38.89Single8JWZAB9288JWZ-A2A-AB928-Na
38.89Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
38.89Consensusgi_class-fOther Ligandgi_frizzled
38.89Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
38.89Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
38.89Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
38.89Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
38.46Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
38.46Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
38.46Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
38.46Single3UZAGTPL92363UZA-A2A-GTPL9236
38.46Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
38.46Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
38.46Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
38.46Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
38.46Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.10Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.50Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
37.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
37.50Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
37.50Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
37.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
37.50Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
37.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
37.50Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.50Single8CU6LJ-45178CU6-A2A-LJ-4517
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
37.50Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
37.50Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
37.50Consensusblt_onOrthosteric Ligandblt1_on
37.50Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
37.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
37.50Consensusleuko_onOrthosteric Ligandblt_on
36.84Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.84Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.84Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.84Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
36.84Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
36.84Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
36.84Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Consensusorexin_onOrthosteric Ligandox2_on
36.84Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.36Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
36.36Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
36.36Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
36.36Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
36.36Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
35.71Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
35.71Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
35.71Single6HLLCP999946HLL-NK1-CP99994
35.71Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
35.71Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.71Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
35.29Single5CGCHTL142425CGC-mGlu5-HTL14242
35.29Single5NM2ZM2413855NM2-A2A-ZM241385-Na
35.29Single6LUQHaloperidol6LUQ-D2-Haloperidol
35.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
35.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
35.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7XN9L-054,5227XN9-SST2-L-054,522
35.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
33.33Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
33.33Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
33.33Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
33.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
33.33Consensusgt_class-aOrthosteric Ligandgt_opsin
33.33Consensusgt_opsinOrthosteric Ligandgt_sensory
33.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
33.33Consensusmglu_onOther Ligandmglu2_on mglu4_on
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
31.82Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
31.82Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
31.82Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.58Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.58Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single8WU1KCA8WU1-CB1-KCA-Arrestin1
31.58Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Consensusgs_steroidOrthosteric Ligandgs_bileacid
31.58Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
31.58Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
31.58Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.25Single5JTBZM2413855JTB-A2A-ZM241385
31.25Single5K2BZM2413855K2B-A2A-ZM241385-Na
31.25Single6AQFZM2413856AQF-A2A-ZM241385
31.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.25Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
31.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
31.25Single6TPKRetosiban6TPK-OT-Retosiban
31.25Single6V9SGTPL114036V9S-OX1-GTPL11403
31.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.25Single6ZG9GSK10347026ZG9-M1-GSK1034702
31.25Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
31.25Single7T32ZM2413857T32-A2A-ZM241385
31.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
31.25Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
31.25Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
31.25Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.25Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
31.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.25Consensusvasopressin-ot_offOrthosteric Ligandot_off
30.77Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
30.77Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
30.77Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
30.77Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.77Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
30.43Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single5CGDHTL142425CGD-mGlu5-HTL14242
30.00Single6K1QIRL25006K1Q-ETB-IRL2500
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
30.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
30.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Consensussteroid_onOrthosteric Ligandbileacid_on
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.63Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
29.63Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single3EMLZM2413853EML-A2A-ZM241385
29.41Single4EIYZM2413854EIY-A2A-ZM241385-Na
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5K2AZM2413855K2A-A2A-ZM241385-Na
29.41Single5OLGZM2413855OLG-A2A-ZM241385-Na
29.41Single5TGZAM65385TGZ-CB1-AM6538
29.41Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
29.41Single5VRAZM2413855VRA-A2A-ZM241385-Na
29.41Single6S0LZM2413856S0L-A2A-ZM241385
29.41Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
29.41Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
29.41Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
29.41Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.41Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
29.41Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
29.41Consensusgi_hcarOrthosteric Ligandgi_hca
29.41Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.17Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.17Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
29.17Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
28.57Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
28.57Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
28.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
28.57Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
28.57Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
27.78Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6LPLZM2413856LPL-A2A-ZM241385-Na
27.78Single6S0QZM2413856S0Q-A2A-ZM241385
27.78Single6WQAZM2413856WQA-A2A-ZM241385-Na
27.78Single7C4SS1P7C4S-S1P3-S1P
27.78Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
27.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
27.78Single7RM5ZM2413857RM5-A2A-ZM241385-Na
27.78Single8FYNZM2413858FYN-A2A-ZM241385-Na
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
27.78Single8QOTNanobody E8QOT-μ-Nanobody E
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
27.59Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
27.27Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7F8XNN90567F8X-CCKA-NN9056
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.27Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
27.27Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.27Consensussst_onOrthosteric Ligandsst2_on sst4_on
26.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.92Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
26.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
26.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
26.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
26.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
26.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
26.67Single8K5BNiacin8K5B-HCA2-Niacin
26.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.32Single5XR8AM8415XR8-CB1-AM841
26.32Single5XRAAM115425XRA-CB1-AM11542
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
26.32Single7P2L4YI7P2L-mGlu5-4YI
26.32Single7PX4PSB-21137PX4-A2A-PSB-2113
26.32Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
26.32Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.32Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.32Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
26.32Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
26.32Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
26.32Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
26.32Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Consensuslpa_onOrthosteric Ligandlpa1_on
26.32Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.09Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.09Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
26.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
26.09Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.09Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
25.93Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single5K2DZM2413855K2D-A2A-ZM241385
25.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
25.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
25.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
25.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
25.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
25.00Single8IHKAcifran8IHK-HCA3-Acifran
25.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
25.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
25.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
24.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
24.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
24.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
24.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
23.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
23.81Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
23.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
23.81Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
23.81Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.81Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.53Single3REYPubChem 56973REY-A2A-PubChem 5697
23.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
23.53Single5IU4ZM2413855IU4-A2A-ZM241385-Na
23.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
23.53Single5K2CZM2413855K2C-A2A-ZM241385-Na
23.53Single5NLXZM2413855NLX-A2A-ZM241385-Na
23.53Single5NM4ZM2413855NM4-A2A-ZM241385-Na
23.53Single5UVIZM2413855UVI-A2A-ZM241385
23.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
23.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.53Single6MH8ZM2413856MH8-A2A-ZM241385
23.53Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.53Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
23.53Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
23.53Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.53Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.53Consensushca_onOrthosteric Ligandhca2_on hca3_on
23.53Consensushcar_onOrthosteric Ligandhca_on
23.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
23.53Consensuss1p_offOrthosteric Ligands1p1_off
23.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
22.73Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single4YAYZD-71554YAY-AT1-ZD-7155
22.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6FFHFenobam6FFH-mGlu5-Fenobam
22.22Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
22.22Single6GPSMK08126GPS-CCR2-MK0812
22.22Single6IIVDaltroban6IIV-TP-Daltroban
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
22.22Single6LPJZM2413856LPJ-A2A-ZM241385-Na
22.22Single6LPKZM2413856LPK-A2A-ZM241385-Na
22.22Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
22.22Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
22.22Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8K5DGSK2560738K5D-HCA2-GSK256073
22.22Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
22.22Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
22.22Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
22.22Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
22.22Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
22.22Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.22Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
22.22Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
21.88Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.88Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
21.74Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
21.74Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.74Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.43Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single6GPXMK08126GPX-CCR2-MK0812
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
21.05Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
21.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
21.05Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
21.05Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
21.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.05Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
21.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.05Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
20.83Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.83Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.83Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.83Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.69Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.69Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
20.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single6W25SHU91196W25-MC4-SHU9119-Ca
20.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.00Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
20.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
20.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
19.35Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
19.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
19.23Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Consensusclass-d_onOrthosteric Ligandste2_on
19.23Consensusgi_class-dOrthosteric Ligandgi_ste
19.23Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
19.05Single5X33BIIL2605X33-BLT1-BIIL260
19.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
19.05Single6IIURamatroban6IIU-TP-Ramatroban
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
19.05Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
19.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
19.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
19.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
19.05Consensusdp_offOrthosteric Liganddp2_off
19.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
19.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
18.75Consensusgo_class-b2Orthosteric Ligandgo_adhesion
18.52Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.52Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
18.52Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
18.18Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
18.18Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
18.18Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
18.18Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.18Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensusclass-d_onOrthosteric Ligandste2_on
17.86Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
17.86Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
17.65Single3PWHZM2413853PWH-A2A-ZM241385
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
17.39Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
17.39Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
17.39Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusgs_class-b2Orthosteric Ligandgs_adgr
17.39Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
17.24Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.24Consensusgi_class-dOrthosteric Ligandgi_ste
17.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
16.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
16.67Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.13Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.79Single6D27CAY104716D27-DP2-CAY10471
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.79Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.79Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Consensushcar_offOrthosteric Ligandsuccinate_off
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
15.79Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
15.38Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
15.38Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.38Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.81Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.81Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
14.81Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
14.81Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.81Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.81Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.29Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
14.29Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
14.29Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
14.29Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
14.29Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Consensuschemerin_onOrthosteric Ligandcml1_on
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.64Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.64Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
13.64Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
13.64Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.64Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
13.64Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.51Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
13.33Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon
12.90Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.50Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.50Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.50Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.50Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
12.50Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.12Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.12Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.00Single4XT1Fractalkine4XT1-US28-Fractalkine
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
12.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
11.76Single3OE9IT1t3OE9-CXCR4-IT1t
11.76Single5L7IVismodegib5L7I-SMO-Vismodegib
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.76Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Consensusclass-t_onOrthosteric Ligandtaste2_on
11.76Consensusgs_class-tOrthosteric Ligandgs_taste
11.76Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.76Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.54Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
11.43Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
11.43Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single3OE0CVX153OE0-CXCR4-CVX15
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.11Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
11.11Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
10.71Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.71Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.34Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.34Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.34Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.26Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.00Single4XT3Fractalkine4XT3-US28-Fractalkine
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.00Single6FJ3PTH6FJ3-PTH1-PTH
10.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.00Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.68Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
9.68Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
9.68Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.68Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.52Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.38Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.38Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
9.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.38Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.09Single5V56TC1145V56-SMO-TC114
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.82Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.70Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
8.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.41Single7SK5CXCL127SK5-ACKR3-CXCL12
7.41Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Consensussst_offOrthosteric Ligandsst2_off
7.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Single7XNACYN1548067XNA-SST2-CYN154806
7.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
6.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.45Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.45Single7SK3CXCL127SK3-ACKR3-CXCL12
6.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.45Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
6.45Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.45Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.25Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.25Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.25Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.06Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.06Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.88Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.88Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.88Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.56Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.56Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.26Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.26Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.13Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.76Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.55Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.55Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.35Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.35Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.35Single5V57TC1145V57-SMO-TC114
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.35Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.35Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.35Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.35Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.17Single4XEENeurotensin4XEE-NTS1-Neurotensin
4.17Single4XESNeurotensin4XES-NTS1-Neurotensin
4.17Single6OS2TRV0266OS2-AT1-TRV026
4.17Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Consensuschemokine_offOrthosteric Ligandcxcr_off
4.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.17Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.17Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
4.17Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Consensusnts_offOrthosteric Ligandnts1_off
4.17Consensusnts_onOrthosteric Ligandnts1_on
4.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
4.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.70Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
3.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.03Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
alpha1_on alpha1a_on
alpha2_on alpha2a_on
alpha2b_on
Net Summary
Imin 3.42542
Number of Linked Nodes 264
Number of Links 287
Number of Hubs 28
Number of Links mediated by Hubs 120
Number of Communities 6
Number of Nodes involved in Communities 38
Number of Links involved in Communities 52
Path Summary
Number Of Nodes in MetaPath 74
Number Of Links MetaPath 73
Number of Shortest Paths 53091
Length Of Smallest Path 3
Average Path Length 14.2319
Length of Longest Path 32
Minimum Path Strength 0.269375
Average Path Strength 5.3275
Maximum Path Strength 14.0083
Minimum Path Correlation 0.70125
Average Path Correlation 0.885863
Maximum Path Correlation 0.984583
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 35.0043
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.5287
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
alpha_off_onalpha_offalpha_on
This network is also present in following consensuses:
IdComponents
adrenergic_onbeta_on
alpha_on



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Download alpha_on.zip



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