psnGPCR

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Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha_off Int. Strength	alpha_on Int. Strength	alpha_off Hub1?	alpha_on Hub1?	alpha_off Hub2?	alpha_on Hub2?	ConSurf1	ConSurf2
1	2x63	Lig	alpha_off	100	0	No	No	Yes	Yes	4	0
2	3x28	Lig	alpha_off	100	0	Yes	Yes	Yes	Yes	5	0
3	1x42	7x43	alpha_off	100	0	No	No	No	No	7	5
4	1x53	7x53	alpha_off	100	0	No	No	Yes	Yes	9	9
5	1x60	8x53	alpha_off	100	0	No	No	No	No	6	7
6	2x37	2x40	alpha_off	100	0	No	No	No	No	7	8
7	2x42	4x46	alpha_off	100	0	Yes	Yes	No	No	8	8
8	2x43	7x53	alpha_off	100	0	No	No	Yes	Yes	7	9
9	2x50	3x39	alpha_off	100	0	No	Yes	No	No	9	9
10	2x53	2x56	alpha_off	100	0	No	No	No	No	8	8
11	2x57	7x39	alpha_off	100	0	Yes	No	No	No	8	6
12	2x57	7x42	alpha_off	100	0	Yes	No	Yes	Yes	8	7
13	2x59	3x24	alpha_off	100	0	No	No	Yes	Yes	5	5
14	3x24	E1x50	alpha_off	100	0	Yes	Yes	Yes	Yes	5	8
15	3x22	E2	alpha_off	100	0	No	No	Yes	Yes	5	4
16	3x33	4x57	alpha_off	100	0	No	No	No	No	6	8
17	3x37	4x57	alpha_off	100	0	No	No	No	No	7	8
18	3x39	6x44	alpha_off	100	0	No	No	Yes	Yes	9	9
19	3x39	7x49	alpha_off	100	0	No	No	No	Yes	9	9
20	3x40	6x44	alpha_off	100	0	No	No	Yes	Yes	8	9
21	3x41	4x52	alpha_off	100	0	No	No	No	No	6	5
22	3x41	4x53	alpha_off	100	0	No	No	No	No	6	8
23	3x43	6x41	alpha_off	100	0	No	No	No	No	8	8
24	3x43	6x44	alpha_off	100	0	No	No	Yes	Yes	8	9
25	3x44	5x53	alpha_off	100	0	No	No	No	No	6	6
26	4x38	4x41	alpha_off	100	0	No	No	No	No	7	6
27	4x60	5x42	alpha_off	100	0	Yes	No	No	No	7	5
28	E2	E2	alpha_off	100	0	Yes	Yes	Yes	Yes	4	4
29	5x41	6x60	alpha_off	100	0	No	No	No	No	6	5
30	5x58	5x61	alpha_off	100	0	Yes	Yes	No	No	9	9
31	5x58	I3	alpha_off	100	0	Yes	Yes	Yes	No	9	3
32	5x71	I3	alpha_off	100	0	No	No	Yes	No	4	3
33	5x72	I3	alpha_off	100	0	No	No	Yes	No	6	3
34	5x76	I3	alpha_off	100	0	No	No	Yes	No	2	3
35	I3	I3	alpha_off	100	0	Yes	No	Yes	No	3	3
36	6x39	7x52	alpha_off	100	0	No	No	No	No	7	8
37	6x48	6x51	alpha_off	100	0	Yes	Yes	Yes	Yes	8	7
38	6x51	6x52	alpha_off	100	0	Yes	Yes	Yes	Yes	7	7
39	6x54	E3	alpha_off	100	0	No	No	Yes	Yes	5	3
40	E3	E3	alpha_off	100	0	Yes	Yes	Yes	Yes	3	3
41	7x34	7x38	alpha_off	100	0	No	No	Yes	No	4	6
42	7x35	7x38	alpha_off	100	0	No	No	Yes	No	5	6
43	7x53	8x50	alpha_off	100	0	Yes	Yes	Yes	Yes	9	8
44	8x50	8x54	alpha_off	100	0	Yes	Yes	Yes	No	8	7
45	E2	NT	alpha_off	100	0	Yes	Yes	Yes	No	4	0
46	E1x49	NT	alpha_off	100	0	No	No	Yes	No	4	0
47	2x64	NT	alpha_off	100	0	No	No	Yes	No	5	0
48	2x65	NT	alpha_off	100	0	No	No	Yes	No	5	0
49	1x42	2x57	alpha_off	100	0	No	No	Yes	No	7	8
50	2x59	E1x52	alpha_off	100	0	No	No	No	No	5	5
51	2x61	2x65	alpha_off	100	0	No	No	No	No	6	5
52	E1x49	E2	alpha_off	100	0	No	No	Yes	Yes	4	4
53	3x43	5x54	alpha_off	100	0	No	No	No	No	8	8
54	3x50	6x34	alpha_off	100	0	No	No	No	No	9	0
55	4x58	4x60	alpha_off	100	0	No	No	Yes	No	4	7
56	5x67	5x68	alpha_off	100	0	No	No	No	No	5	7
57	6x29	8x49	alpha_off	100	0	No	No	Yes	Yes	0	7
58	6x33	6x37	alpha_off	100	0	No	No	No	No	0	0
59	6x40	7x49	alpha_off	100	0	No	No	No	Yes	8	9
60	6x44	7x45	alpha_off	100	0	Yes	Yes	No	No	9	9
61	6x58	6x62	alpha_off	100	0	No	No	No	No	4	0
62	6x39	7x56	alpha_off	50	0	No	No	No	No	7	7
63	7x49	7x53	alpha_off	50	0	No	Yes	Yes	Yes	9	9
64	5x44	6x52	alpha_off	50	0	No	No	Yes	Yes	7	7
65	6x58	E2	alpha_off	50	0	No	No	Yes	Yes	4	4
66	2x40	2x43	alpha_off	50	0	No	No	No	No	8	7
67	1x53	2x47	alpha_off	50	0	No	No	No	No	9	9
68	8x56	CT	alpha_off	50	0	No	No	No	No	5	7
69	E2x52	Lig	alpha_off	50	0	No	No	Yes	Yes	6	0
70	5x51	6x45	alpha_off	50	0	No	No	No	No	6	5
71	7x33	E3	alpha_off	50	0	No	No	Yes	Yes	5	3
72	5x37	6x62	alpha_off	50	0	No	No	No	No	4	0
73	3x50	6x33	alpha_off	50	0	No	No	No	No	9	0
74	6x40	7x52	alpha_off	50	0	No	No	No	No	8	8
75	6x33	8x47	alpha_off	50	0	No	No	No	No	0	8
76	5x58	5x62	alpha_off	50	0	Yes	Yes	No	Yes	9	5
77	3x50	6x30	alpha_off	50	0	No	No	No	No	9	0
78	4x64	5x38	alpha_off	50	0	No	No	No	Yes	6	5
79	3x55	3x56	alpha_off	50	0	No	No	No	No	7	6
80	5x58	6x38	alpha_off	50	0	Yes	Yes	No	No	9	0
81	1x57	8x50	alpha_off	50	0	No	No	Yes	Yes	8	8
82	1x60	8x56	alpha_off	50	0	No	No	No	No	6	5
83	1x43	2x58	alpha_off	50	0	No	No	No	No	5	9
84	1x33	1x34	alpha_off	50	0	No	No	No	No	6	4
85	3x29	E2x50	alpha_off	50	0	No	No	No	No	6	9
86	1x51	1x55	alpha_off	0	0	No	No	No	No	4	4
87	2x62	2x66	alpha_off	50	0	No	No	No	No	5	5
88	1x52	8x58	alpha_off	0	0	No	No	No	No	7	7
89	I1x48	I1x49	alpha_off	0	0	No	No	No	No	7	6
90	5x70	I3	alpha_off	50	0	No	No	Yes	No	5	3
91	3x30	4x59	alpha_off	0	0	No	No	No	No	6	7
92	8x51	8x55	alpha_off	0	0	No	No	No	No	8	5
93	7x30	7x32	alpha_off	0	0	No	No	No	No	5	1
94	4x56	5x46	alpha_off	0	0	No	No	No	No	6	5
95	4x61	5x39	alpha_off	50	0	No	No	Yes	Yes	5	8
96	1x35	NT	alpha_off	0	0	No	No	Yes	No	5	0
97	6x47	7x40	alpha_off	0	0	No	No	No	No	8	7
98	1x46	7x46	alpha_off	0	0	No	No	No	No	8	9
99	6x29	6x32	alpha_off	0	0	No	No	No	No	0	0
100	1x47	1x51	alpha_off	0	0	No	No	No	No	6	4
101	1x30	1x33	alpha_off	50	0	No	No	No	No	4	6
102	I2x56	I2x57	alpha_off	50	0	No	No	Yes	Yes	5	6
103	5x74	I3	alpha_off	50	0	No	No	Yes	No	4	3
104	7x47	7x48	alpha_off	0	0	No	No	No	No	6	6
105	4x62	E2x52	alpha_off	0	0	No	No	No	No	4	6
106	3x34	4x54	alpha_off	0	0	No	No	No	No	6	4
107	3x21	E1x50	alpha_off	0	0	No	No	Yes	Yes	8	8
108	2x52	2x551	alpha_off	0	0	No	No	No	No	6	6
109	2x551	3x31	alpha_off	0	0	No	No	No	No	6	5
110	2x62	E1x52	alpha_off	0	0	No	No	No	No	5	5
111	5x69	5x70	alpha_off	0	0	No	No	No	No	5	5
112	1x40	1x41	alpha_off	0	0	No	No	No	No	3	5
113	2x67	NT	alpha_off	0	0	No	No	Yes	No	4	0
114	1x34	1x37	alpha_off	0	0	No	No	No	No	4	5
115	5x54	5x55	alpha_off	0	0	No	No	No	No	8	5
116	1x59	8x57	alpha_off	0	0	No	No	No	Yes	5	6
117	1x28	1x31	alpha_off	0	0	No	No	No	Yes	0	3
118	3x29	E2x51	alpha_off	0	0	No	No	No	No	6	5
119	4x39	4x43	alpha_off	0	0	No	No	No	No	4	5
120	5x65	6x31	alpha_off	0	0	No	No	No	No	8	0
121	1x38	1x39	alpha_off	0	0	No	No	No	No	5	7
122	1x44	1x48	alpha_off	0	0	No	No	No	No	4	4
123	1x54	2x48	alpha_off	0	0	No	No	No	No	7	6
124	3x54	5x65	alpha_off	0	0	No	No	No	No	8	8
125	5x63	5x66	alpha_off	0	0	No	No	No	No	4	5
126	3x56	I2x50	alpha_off	0	0	No	No	No	No	6	8
127	4x43	4x47	alpha_off	0	0	No	No	No	No	5	4
128	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
129	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
130	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
131	5x43	Lig	Shared	100	100	No	No	Yes	Yes	7	0
132	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
133	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
134	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
135	7x38	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
136	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
137	1x39	2x61	Shared	100	100	No	No	No	No	7	6
138	1x39	7x39	Shared	100	100	No	No	No	No	7	6
139	1x43	2x57	Shared	100	100	No	No	Yes	No	5	8
140	1x49	7x50	Shared	100	58.3333	No	No	No	No	9	9
141	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
142	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
143	1x51	2x51	Shared	100	16.6667	No	No	No	No	4	7
144	1x52	8x54	Shared	100	100	No	No	Yes	No	7	7
145	1x56	8x54	Shared	100	50	No	No	Yes	No	8	7
146	1x57	2x44	Shared	100	100	No	No	No	No	8	6
147	1x60	I1x50	Shared	100	100	No	No	No	Yes	6	8
148	8x49	I1x49	Shared	100	100	Yes	Yes	No	No	7	6
149	2x37	2x39	Shared	100	100	No	No	No	No	7	8
150	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
151	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
152	2x42	3x49	Shared	100	100	Yes	Yes	Yes	Yes	8	9
153	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	7
154	2x45	4x46	Shared	100	100	No	Yes	No	No	9	8
155	2x45	4x50	Shared	100	100	No	Yes	No	Yes	9	9
156	2x46	3x42	Shared	100	100	No	Yes	No	Yes	9	7
157	2x53	3x35	Shared	100	100	No	No	No	Yes	8	6
158	2x55	2x551	Shared	100	100	No	No	No	No	5	6
159	2x56	3x28	Shared	100	100	No	No	Yes	Yes	8	5
160	2x56	3x32	Shared	100	100	No	No	No	No	8	7
161	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
162	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	4	8
163	2x64	7x35	Shared	100	100	No	No	No	No	5	5
164	E1x49	E1x51	Shared	100	100	No	No	No	No	4	3
165	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	8	5
166	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
167	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	8
168	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
169	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
170	3x31	3x35	Shared	100	100	No	No	No	Yes	5	6
171	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
172	3x34	4x57	Shared	100	100	No	No	No	No	6	8
173	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
174	3x37	5x461	Shared	100	100	No	No	No	No	7	6
175	3x38	4x50	Shared	100	100	No	No	No	Yes	8	9
176	3x38	4x53	Shared	100	50	No	No	No	No	8	8
177	3x40	5x50	Shared	100	100	No	No	No	No	8	9
178	3x48	3x52	Shared	100	100	No	No	No	No	6	5
179	3x49	I2x53	Shared	100	100	Yes	Yes	No	Yes	9	7
180	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	6
181	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
182	3x51	5x57	Shared	100	100	No	Yes	No	No	8	6
183	3x54	5x61	Shared	100	0	No	No	No	No	8	9
184	I2x53	I2x57	Shared	100	100	No	Yes	Yes	Yes	7	6
185	4x59	4x60	Shared	100	100	No	No	Yes	No	7	7
186	5x36	E2	Shared	100	100	No	No	Yes	Yes	6	4
187	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	8	4
188	5x39	5x43	Shared	100	100	Yes	Yes	No	No	8	7
189	5x40	6x55	Shared	100	100	No	No	No	Yes	6	7
190	5x40	6x59	Shared	100	16.6667	No	No	No	No	6	5
191	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	8	6
192	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
193	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	8	9
194	5x47	6x49	Shared	100	100	Yes	Yes	No	Yes	8	7
195	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
196	6x43	7x52	Shared	100	100	No	No	No	No	7	8
197	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
198	6x47	7x45	Shared	100	100	No	No	No	No	8	9
199	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
200	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
201	6x51	6x55	Shared	100	100	Yes	Yes	No	Yes	7	7
202	6x51	7x34	Shared	100	100	Yes	Yes	No	No	7	4
203	6x51	7x38	Shared	100	100	Yes	Yes	Yes	No	7	6
204	6x61	E3	Shared	100	50	No	No	Yes	Yes	4	3
205	7x36	7x40	Shared	100	100	No	No	No	No	5	7
206	7x39	7x42	Shared	100	100	No	No	Yes	Yes	6	7
207	7x54	8x54	Shared	100	100	No	No	Yes	No	7	7
208	7x55	7x56	Shared	100	100	No	No	No	No	5	7
209	8x47	8x49	Shared	100	100	No	No	Yes	Yes	8	7
210	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
211	8x50	I1x50	Shared	100	100	Yes	Yes	No	Yes	8	8
212	2x38	4x39	Shared	100	100	No	No	No	No	7	4
213	2x39	I2x57	Shared	100	100	No	No	Yes	Yes	8	6
214	2x45	3x42	Shared	100	100	No	Yes	No	Yes	9	7
215	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
216	2x52	3x35	Shared	100	100	No	No	No	Yes	6	6
217	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
218	3x23	3x24	Shared	100	25	No	No	Yes	Yes	3	5
219	3x24	3x27	Shared	100	50	Yes	Yes	No	No	5	5
220	3x47	5x57	Shared	100	100	No	No	No	No	9	6
221	3x51	5x60	Shared	100	100	No	Yes	No	No	8	6
222	3x52	I2x53	Shared	100	100	No	No	No	Yes	5	7
223	3x53	I2x57	Shared	100	100	No	No	Yes	Yes	8	6
224	4x41	I2x56	Shared	100	50	No	No	No	No	6	5
225	5x36	5x38	Shared	100	100	No	No	No	Yes	6	5
226	5x58	6x41	Shared	100	100	Yes	Yes	No	No	9	8
227	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
228	6x50	7x37	Shared	100	100	No	No	No	No	9	5
229	6x58	E3	Shared	100	50	No	No	Yes	Yes	4	3
230	8x48	8x49	Shared	100	16.6667	No	No	Yes	Yes	5	7
231	8x58	8x59	Shared	100	16.6667	No	No	No	No	7	5
232	3x42	4x49	Shared	50	100	No	Yes	No	No	7	6
233	1x46	7x47	Shared	50	100	No	No	No	No	8	6
234	5x48	6x56	Shared	50	100	No	Yes	No	No	6	6
235	6x35	6x39	Shared	50	100	No	No	No	No	0	7
236	6x60	6x61	Shared	50	16.6667	No	No	No	No	5	4
237	3x47	5x58	Shared	50	100	No	No	Yes	Yes	9	9
238	8x48	8x51	Shared	50	16.6667	No	No	No	No	5	8
239	6x53	6x57	Shared	50	100	No	No	No	No	6	5
240	7x33	7x37	Shared	50	100	No	No	No	No	5	5
241	I2x54	I2x57	Shared	50	0	No	No	Yes	Yes	6	6
242	8x48	8x52	Shared	50	50	No	No	No	No	5	5
243	1x52	8x57	Shared	0	66.6667	No	No	No	Yes	7	6
244	4x60	5x39	Shared	50	100	Yes	No	Yes	Yes	7	8
245	1x45	7x47	Shared	50	100	No	No	No	No	5	6
246	2x42	4x45	Shared	50	100	Yes	Yes	No	No	8	6
247	4x40	4x44	Shared	50	0	No	No	No	No	5	3
248	1x54	2x47	Shared	50	100	No	No	No	No	7	9
249	1x32	2x65	Shared	0	16.6667	No	No	No	No	4	5
250	3x37	4x56	Shared	0	100	No	No	No	No	7	6
251	2x41	4x42	Shared	0	100	No	No	No	No	5	7
252	1x55	8x57	Shared	0	100	No	No	No	Yes	4	6
253	7x31	7x32	Shared	0	8.33333	No	No	No	No	2	1
254	2x42	3x45	Shared	0	16.6667	Yes	Yes	No	No	8	7
255	6x36	7x56	Shared	0	100	No	No	No	No	0	7
256	5x64	5x68	Shared	0	0	No	No	No	No	6	7
257	1x45	7x51	Shared	0	0	No	No	No	No	5	6
258	3x44	5x50	Shared	0	100	No	No	No	No	6	9
259	7x30	E3	Shared	0	50	No	No	Yes	Yes	5	3
260	5x49	5x50	Shared	0	8.33333	No	No	No	No	5	9
261	4x38	4x39	Shared	0	50	No	No	No	No	7	4
262	1x46	2x54	Shared	0	100	No	No	No	No	8	7
263	3x54	5x64	Shared	0	50	No	No	No	No	8	6
264	1x54	1x58	Shared	0	66.6667	No	No	No	No	7	2
265	4x47	4x51	Shared	0	0	No	No	No	No	4	4
266	I2x51	I2x52	Shared	0	8.33333	No	No	No	No	7	5
267	5x52	5x56	Shared	0	16.6667	No	No	No	No	4	4
268	1x31	NT	Shared	0	8.33333	No	Yes	Yes	No	3	0
269	2x49	4x50	Shared	0	25	No	No	No	Yes	8	9
270	4x38	4x40	Shared	0	16.6667	No	No	No	No	7	5
271	3x56	I2x52	Shared	0	100	No	No	No	No	6	5
272	I1x48	I1x51	Shared	0	100	No	No	No	No	7	8
273	1x41	1x45	Shared	0	25	No	No	No	No	5	5
274	1x48	1x49	Shared	0	8.33333	No	No	No	No	4	9
275	5x45	5x46	Shared	0	75	No	No	No	No	4	5
276	1x36	2x61	Shared	0	100	No	No	No	No	6	6
277	I2x55	I2x56	Shared	0	0	No	No	No	No	4	5
278	6x28	6x32	Shared	0	16.6667	No	No	No	No	0	0
279	1x46	1x50	alpha_on	0	100	No	No	No	Yes	8	9
280	1x50	2x47	alpha_on	0	100	No	Yes	No	No	9	9
281	1x57	2x40	alpha_on	0	100	No	No	No	No	8	8
282	2x40	I1x50	alpha_on	0	100	No	No	No	Yes	8	8
283	8x49	I1x50	alpha_on	0	100	Yes	Yes	No	Yes	7	8
284	2x40	8x50	alpha_on	0	100	No	No	Yes	Yes	8	8
285	2x43	8x50	alpha_on	0	100	No	No	Yes	Yes	7	8
286	2x46	7x49	alpha_on	0	100	No	Yes	No	Yes	9	9
287	2x53	7x46	alpha_on	0	100	No	No	No	No	8	9
288	2x551	3x35	alpha_on	0	100	No	No	No	Yes	6	6
289	2x56	7x42	alpha_on	0	100	No	No	Yes	Yes	8	7
290	2x57	2x58	alpha_on	0	100	Yes	No	No	No	8	9
291	2x60	3x28	alpha_on	0	100	No	No	Yes	Yes	7	5
292	2x66	E1x49	alpha_on	0	100	No	No	No	No	5	4
293	E1x51	E1x52	alpha_on	0	100	No	No	No	No	3	5
294	3x24	E1x52	alpha_on	0	100	Yes	Yes	No	No	5	5
295	3x38	3x42	alpha_on	0	100	No	No	No	Yes	8	7
296	3x40	6x48	alpha_on	0	100	No	No	Yes	Yes	8	8
297	3x41	4x49	alpha_on	0	100	No	No	No	No	6	6
298	3x43	7x49	alpha_on	0	100	No	No	No	Yes	8	9
299	3x43	7x53	alpha_on	0	100	No	No	Yes	Yes	8	9
300	3x46	3x50	alpha_on	0	100	No	No	No	No	9	9
301	4x58	4x59	alpha_on	0	100	No	No	No	No	4	7
302	6x55	E2x52	alpha_on	0	100	No	Yes	No	No	7	6
303	5x48	6x52	alpha_on	0	100	No	Yes	Yes	Yes	6	7
304	5x54	5x58	alpha_on	0	100	No	No	Yes	Yes	8	9
305	5x55	6x41	alpha_on	0	100	No	No	No	No	5	8
306	6x30	6x33	alpha_on	0	100	No	No	No	No	0	0
307	6x40	7x53	alpha_on	0	100	No	No	Yes	Yes	8	9
308	6x48	7x45	alpha_on	0	100	Yes	Yes	No	No	8	9
309	6x48	Lig	alpha_on	0	100	Yes	Yes	Yes	Yes	8	0
310	6x49	6x50	alpha_on	0	100	No	Yes	No	No	7	9
311	6x54	7x34	alpha_on	0	100	No	No	No	No	5	4
312	6x54	7x37	alpha_on	0	100	No	No	No	No	5	5
313	7x38	7x42	alpha_on	0	100	Yes	No	Yes	Yes	6	7
314	7x45	7x49	alpha_on	0	100	No	No	No	Yes	9	9
315	7x52	7x53	alpha_on	0	100	No	No	Yes	Yes	8	9
316	7x54	8x50	alpha_on	0	100	No	No	Yes	Yes	7	8
317	2x46	2x50	alpha_on	0	100	No	Yes	No	Yes	9	9
318	2x50	7x49	alpha_on	0	100	No	Yes	No	Yes	9	9
319	3x34	3x35	alpha_on	0	100	No	No	No	Yes	6	6
320	3x42	4x50	alpha_on	0	100	No	Yes	No	Yes	7	9
321	3x47	5x54	alpha_on	0	100	No	No	No	No	9	8
322	3x50	5x58	alpha_on	0	100	No	No	Yes	Yes	9	9
323	3x50	7x53	alpha_on	0	100	No	No	Yes	Yes	9	9
324	3x51	3x52	alpha_on	0	100	No	Yes	No	No	8	5
325	E2	E2x51	alpha_on	0	100	Yes	Yes	No	No	4	5
326	5x44	6x56	alpha_on	0	100	No	No	No	No	7	6
327	5x45	5x48	alpha_on	0	100	No	No	No	Yes	4	6
328	5x461	Lig	alpha_on	0	100	No	No	Yes	Yes	6	0
329	5x47	6x48	alpha_on	0	100	Yes	Yes	Yes	Yes	8	8
330	5x51	6x44	alpha_on	0	100	No	No	Yes	Yes	6	9
331	5x54	6x44	alpha_on	0	100	No	No	Yes	Yes	8	9
332	5x58	6x37	alpha_on	0	100	Yes	Yes	No	No	9	0
333	5x58	6x40	alpha_on	0	100	Yes	Yes	No	No	9	8
334	5x62	5x66	alpha_on	0	100	No	Yes	No	No	5	5
335	5x62	6x33	alpha_on	0	100	No	Yes	No	No	5	0
336	5x62	6x34	alpha_on	0	100	No	Yes	No	No	5	0
337	5x65	6x33	alpha_on	0	100	No	No	No	No	8	0
338	1x42	7x47	alpha_on	0	100	No	No	No	No	7	6
339	4x59	5x39	alpha_on	0	100	No	No	Yes	Yes	7	8
340	5x38	5x39	alpha_on	0	100	No	Yes	Yes	Yes	5	8
341	5x44	5x48	alpha_on	0	100	No	No	No	Yes	7	6
342	5x44	6x55	alpha_on	0	100	No	No	No	Yes	7	7
343	5x69	6x26	alpha_on	0	100	No	No	No	Yes	5	0
344	7x34	7x35	alpha_on	0	100	No	No	No	No	4	5
345	3x21	3x24	alpha_on	0	100	No	No	Yes	Yes	8	5
346	3x56	I2x53	alpha_on	0	100	No	No	No	Yes	6	7
347	4x58	4x62	alpha_on	0	100	No	No	No	No	4	4
348	5x38	E2	alpha_on	0	100	No	Yes	Yes	Yes	5	4
349	6x45	6x49	alpha_on	0	25	No	No	No	Yes	5	7
350	1x50	2x51	alpha_on	0	50	No	Yes	No	No	9	7
351	2x41	4x43	alpha_on	0	16.6667	No	No	No	No	5	5
352	3x25	3x29	alpha_on	0	58.3333	No	No	No	No	9	6
353	5x62	6x37	alpha_on	0	58.3333	No	Yes	No	No	5	0
354	2x46	3x39	alpha_on	0	66.6667	No	Yes	No	No	9	9
355	4x41	4x45	alpha_on	0	16.6667	No	No	No	No	6	6
356	3x51	5x61	alpha_on	0	16.6667	No	Yes	No	No	8	9
357	2x38	I2x57	alpha_on	0	25	No	No	Yes	Yes	7	6
358	1x53	7x54	alpha_on	0	66.6667	No	No	No	No	9	7
359	8x53	8x56	alpha_on	0	50	No	No	No	No	7	5
360	2x54	2x57	alpha_on	0	16.6667	No	No	Yes	No	7	8
361	3x22	3x26	alpha_on	0	50	No	No	No	No	5	6
362	5x41	6x59	alpha_on	0	58.3333	No	No	No	No	6	5
363	5x37	6x60	alpha_on	0	50	No	No	No	No	4	5
364	6x41	6x42	alpha_on	0	0	No	No	No	No	8	5
365	5x60	5x63	alpha_on	0	50	No	No	No	No	6	4
366	8x56	8x57	alpha_on	0	8.33333	No	No	No	Yes	5	6
367	6x43	7x48	alpha_on	0	8.33333	No	No	No	No	7	6
368	1x55	1x59	alpha_on	0	50	No	No	No	No	4	5
369	7x33	7x36	alpha_on	0	50	No	No	No	No	5	5
370	5x69	6x30	alpha_on	0	16.6667	No	No	No	No	5	0
371	5x53	5x57	alpha_on	0	8.33333	No	No	No	No	6	6
372	1x53	7x50	alpha_on	0	0	No	No	No	No	9	9
373	1x43	1x47	alpha_on	0	50	No	No	No	No	5	6
374	1x36	2x65	alpha_on	0	50	No	No	No	No	6	5
375	2x62	E1x51	alpha_on	0	0	No	No	No	No	5	3
376	8x57	8x58	alpha_on	0	50	No	Yes	No	No	6	7
377	6x57	E3	alpha_on	0	50	No	No	Yes	Yes	5	3
378	6x39	6x43	alpha_on	0	0	No	No	No	No	7	7
379	5x69	6x29	alpha_on	0	0	No	No	No	No	5	0
380	5x55	5x59	alpha_on	0	0	No	No	No	No	5	3
381	6x27	6x31	alpha_on	0	16.6667	No	No	No	No	0	0
382	1x40	1x43	alpha_on	0	16.6667	No	No	No	No	3	5
383	7x31	E3	alpha_on	0	25	No	No	Yes	Yes	2	3
384	4x48	4x52	alpha_on	0	16.6667	No	No	No	No	2	5
385	7x55	8x51	alpha_on	0	0	No	No	No	No	5	8
386	5x64	5x67	alpha_on	0	16.6667	No	No	No	No	6	5
387	6x28	6x29	alpha_on	0	8.33333	No	No	No	No	0	0
388	1x31	1x34	alpha_on	0	25	No	Yes	No	No	3	4
389	4x54	4x57	alpha_on	0	0	No	No	No	No	4	8
390	3x26	4x61	alpha_on	0	8.33333	No	No	No	No	6	5
391	6x47	7x43	alpha_on	0	0	No	No	No	No	8	5
392	4x52	4x55	alpha_on	0	8.33333	No	No	No	No	5	4
393	1x31	1x32	alpha_on	0	0	No	Yes	No	No	3	4
394	3x30	4x60	alpha_on	0	0	No	No	Yes	No	6	7
395	1x44	1x47	alpha_on	0	0	No	No	No	No	4	6
396	5x70	6x26	alpha_on	0	8.33333	No	No	No	Yes	5	0
397	1x33	2x65	alpha_on	0	0	No	No	No	No	6	5
398	3x30	4x61	alpha_on	0	0	No	No	No	No	6	5
399	4x52	4x56	alpha_on	0	8.33333	No	No	No	No	5	6
400	6x46	6x47	alpha_on	0	8.33333	No	No	No	No	5	8
401	5x48	5x52	alpha_on	0	8.33333	No	Yes	No	No	6	4
402	8x59	CT	alpha_on	0	0	No	No	No	No	5	7
403	6x26	6x27	alpha_on	0	8.33333	No	Yes	No	No	0	0
404	2x45	2x48	alpha_on	0	16.6667	No	Yes	No	No	9	6
405	1x35	7x35	alpha_on	0	8.33333	No	No	No	No	5	5
406	2x66	2x67	alpha_on	0	0	No	No	No	No	5	4
407	6x26	I3	alpha_on	0	8.33333	No	Yes	Yes	No	0	3
408	1x30	1x31	alpha_on	0	8.33333	No	No	No	Yes	4	3
409	1x29	1x30	alpha_on	0	8.33333	No	No	No	No	0	4
410	1x58	I1x51	alpha_on	0	8.33333	No	No	No	No	2	8
411	5x38	5x42	alpha_on	0	8.33333	No	Yes	No	No	5	5
412	6x24	6x25	alpha_on	0	0	No	No	No	No	0	0
413	1x35	1x38	alpha_on	0	8.33333	No	No	No	No	5	5
414	6x25	6x28	alpha_on	0	0	No	No	No	No	0	0
415	I2x50	I2x51	alpha_on	0	0	No	No	No	No	8	7
416	1x36	1x37	alpha_on	0	0	No	No	No	No	6	5
417	4x51	4x55	alpha_on	0	0	No	No	No	No	4	4

Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha_off Avg Int. Strength	alpha_on Avg Int. Strength	alpha_off Num Of Links	alpha_on Num Of Links	ConSurf
1	2x57	alpha_off	0	0	4	3	8
2	4x60	alpha_off	50	0	4	3	7
3	I3	alpha_off	50	0	8	1	3
4	7x38	alpha_off	50	0	4	3	6
5	8x54	alpha_off	0	0	4	3	7
6	NT	alpha_off	50	0	7	1	0
7	Lig	Shared	100	100	12	11	0
8	2x42	Shared	50	91.6667	6	5	8
9	E1x50	Shared	100	83.3333	7	5	8
10	3x24	Shared	50	0	4	4	5
11	3x28	Shared	50	50	4	4	5
12	3x49	Shared	50	8.33333	4	4	9
13	I2x57	Shared	50	91.6667	6	6	6
14	E2	Shared	100	0	8	4	4
15	5x39	Shared	50	50	4	5	8
16	5x47	Shared	50	91.6667	5	6	8
17	5x58	Shared	50	91.6667	6	6	9
18	6x44	Shared	100	75	6	4	9
19	6x48	Shared	100	100	5	8	8
20	6x51	Shared	100	91.6667	6	4	7
21	6x52	Shared	100	41.6667	5	4	7
22	E3	Shared	50	0	7	5	3
23	7x42	Shared	100	91.6667	5	6	7
24	7x53	Shared	50	91.6667	4	4	9
25	8x49	Shared	50	0	4	4	7
26	8x50	Shared	100	50	5	5	8
27	1x31	alpha_on	0	0	2	4	3
28	1x50	alpha_on	0	91.6667	2	5	9
29	I1x50	alpha_on	0	25	2	4	8
30	2x45	alpha_on	0	0	3	4	9
31	2x46	alpha_on	0	0	1	4	9
32	2x50	alpha_on	0	50	3	4	9
33	3x35	alpha_on	0	50	3	5	6
34	3x42	alpha_on	50	100	3	5	7
35	3x51	alpha_on	50	83.3333	3	5	8
36	I2x53	alpha_on	50	50	3	4	7
37	4x50	alpha_on	0	0	3	4	9
38	5x38	alpha_on	0	0	2	4	5
39	5x48	alpha_on	0	50	2	6	6
40	5x62	alpha_on	0	50	1	4	5
41	6x26	alpha_on	0	0	0	4	0
42	6x49	alpha_on	0	0	2	4	7
43	6x55	alpha_on	100	25	3	5	7
44	7x49	alpha_on	0	16.6667	3	4	9
45	8x57	alpha_on	0	0	3	4	6

Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha_off Recurrence	alpha_on Recurrence	alpha_off Hub1?	alpha_on Hub1?	alpha_off Hub2?	alpha_on Hub2?	ConSurf1	ConSurf2
1	2x63	E1x50	alpha_off	15.4606	4.14311	No	No	Yes	Yes	4	8
2	2x63	Lig	alpha_off	16.4976	0	No	No	Yes	Yes	4	0
3	2x50	3x39	alpha_off	16.8459	0	No	Yes	No	No	9	9
4	3x39	6x44	alpha_off	100	0	No	No	Yes	Yes	9	9
5	5x47	6x52	alpha_off	31.8836	7.89628	Yes	Yes	Yes	Yes	8	7
6	6x48	6x52	alpha_off	30.0773	4.3722	Yes	Yes	Yes	Yes	8	7
7	3x36	6x48	alpha_off	29.7176	1.01872	No	No	Yes	Yes	6	8
8	3x36	Lig	alpha_off	29.5855	0.584909	No	No	Yes	Yes	6	0
9	6x48	6x51	alpha_off	33.8774	0	Yes	Yes	Yes	Yes	8	7
10	8x50	8x54	alpha_off	13.1013	0	Yes	Yes	Yes	No	8	7
11	7x53	8x50	alpha_off	37.754	0	Yes	Yes	Yes	Yes	9	8
12	7x49	7x53	alpha_off	80.814	0	No	Yes	Yes	Yes	9	9
13	3x39	7x49	alpha_off	87.8152	0	No	No	No	Yes	9	9
14	2x37	2x40	alpha_off	42.1664	0	No	No	No	No	7	8
15	2x40	2x43	alpha_off	43.1633	0	No	No	No	No	8	7
16	2x43	7x53	alpha_off	44.1296	0	No	No	Yes	Yes	7	9
17	2x37	2x39	alpha_off	41.1657	1.589	No	No	No	No	7	8
18	2x39	3x49	alpha_off	22.2341	2.88555	No	No	Yes	Yes	8	9
19	2x42	4x46	alpha_off	12.3742	0	Yes	Yes	No	No	8	8
20	2x45	4x46	alpha_off	11.2682	1.78885	No	Yes	No	No	9	8
21	2x53	2x56	alpha_off	21.3214	0	No	No	No	No	8	8
22	3x28	Lig	alpha_off	36.87	0	Yes	Yes	Yes	Yes	5	0
23	5x39	E2	alpha_off	27.9247	4.55254	Yes	Yes	Yes	Yes	8	4
24	3x33	Lig	alpha_off	12.6363	1.59875	No	No	Yes	Yes	6	0
25	3x33	4x57	alpha_off	11.3103	0	No	No	No	No	6	8
26	3x43	6x44	alpha_off	30.6112	0	No	No	Yes	Yes	8	9
27	3x43	6x41	alpha_off	27.4827	0	No	No	No	No	8	8
28	2x39	I2x57	alpha_off	17.9193	0.229089	No	No	Yes	Yes	8	6
29	5x58	6x41	alpha_off	26.4131	7.76467	Yes	Yes	No	No	9	8
30	I2x56	I2x57	alpha_off	12.3742	0	No	No	Yes	Yes	5	6
31	4x41	I2x56	alpha_off	10.1584	2.80269	No	No	No	No	6	5
32	6x58	E2	alpha_off	18.8818	0	No	No	Yes	Yes	4	4
33	6x58	E3	alpha_off	15.363	2.09593	No	No	Yes	Yes	4	3
34	3x28	E1x50	Shared	15.6844	61.1913	Yes	Yes	Yes	Yes	5	8
35	3x32	Lig	Shared	13.0324	23.8009	No	No	Yes	Yes	7	0
36	7x42	Lig	Shared	15.5275	62.2197	Yes	Yes	Yes	Yes	7	0
37	5x47	6x44	Shared	31.9027	11.201	Yes	Yes	Yes	Yes	8	9
38	6x52	Lig	Shared	60.8951	10.9768	Yes	Yes	Yes	Yes	7	0
39	6x44	6x48	Shared	92.9222	49.7368	Yes	Yes	Yes	Yes	9	8
40	6x51	Lig	Shared	29.708	11.2156	Yes	Yes	Yes	Yes	7	0
41	8x47	8x50	Shared	17.3434	14.9883	No	No	Yes	Yes	8	8
42	8x47	8x49	Shared	11.7715	13.3311	No	No	Yes	Yes	8	7
43	2x42	3x49	Shared	18.7115	19.536	Yes	Yes	Yes	Yes	8	9
44	2x56	3x28	Shared	11.7849	45.0868	No	No	Yes	Yes	8	5
45	2x56	3x32	Shared	11.9705	22.7578	No	No	No	No	8	7
46	2x53	3x35	Shared	18.6694	13.994	No	No	No	Yes	8	6
47	5x43	Lig	Shared	37.7215	23.6742	No	No	Yes	Yes	7	0
48	5x39	5x43	Shared	36.6059	22.3777	Yes	Yes	No	No	8	7
49	3x47	5x58	Shared	10.2101	14.998	No	No	Yes	Yes	9	9
50	2x50	7x46	Shared	10.2101	17.3962	No	Yes	No	No	9	9
51	1x36	2x61	alpha_on	1.37385	14.7787	No	No	No	No	6	6
52	1x39	2x61	alpha_on	3.17822	16.2556	No	No	No	No	7	6
53	1x39	7x39	alpha_on	5.43033	17.5424	No	No	No	No	7	6
54	7x39	7x42	alpha_on	6.6224	19.0096	No	No	Yes	Yes	6	7
55	6x48	Lig	alpha_on	0	100	Yes	Yes	Yes	Yes	8	0
56	6x48	7x45	alpha_on	0	77.5005	Yes	Yes	No	No	8	9
57	7x45	7x49	alpha_on	0	76.0382	No	No	No	Yes	9	9
58	2x50	7x49	alpha_on	0	98.45	No	Yes	No	Yes	9	9
59	1x50	2x50	alpha_on	5.70969	90.115	No	Yes	No	Yes	9	9
60	1x46	1x50	alpha_on	0	22.4264	No	No	No	Yes	8	9
61	1x46	2x54	alpha_on	1.14806	12.2782	No	No	No	No	8	7
62	1x50	7x50	alpha_on	4.57503	62.8875	No	Yes	No	No	9	9
63	1x53	7x50	alpha_on	0	58.6469	No	No	No	No	9	9
64	1x53	7x54	alpha_on	0	57.1798	No	No	No	No	9	7
65	7x54	8x54	alpha_on	1.14806	18.6245	No	No	Yes	No	7	7
66	1x52	8x54	alpha_on	9.76235	15.4416	No	No	Yes	No	7	7
67	1x52	8x57	alpha_on	6.61283	13.76	No	No	No	Yes	7	6
68	7x54	8x50	alpha_on	0	39.5886	No	No	Yes	Yes	7	8
69	8x50	I1x50	alpha_on	5.70969	16.6553	Yes	Yes	No	Yes	8	8
70	8x49	I1x50	alpha_on	0	13.487	Yes	Yes	No	Yes	7	8
71	5x54	6x44	alpha_on	0	59.651	No	No	Yes	Yes	8	9
72	5x54	5x58	alpha_on	0	33.9101	No	No	Yes	Yes	8	9
73	3x50	5x58	alpha_on	0	35.7721	No	No	Yes	Yes	9	9
74	3x46	3x50	alpha_on	0	31.0294	No	No	No	No	9	9
75	2x42	3x46	alpha_on	1.14232	29.8986	Yes	Yes	No	No	8	9
76	3x49	I2x57	alpha_on	0.480272	10.8696	Yes	Yes	Yes	Yes	9	6
77	3x47	5x54	alpha_on	0	25.0195	No	No	No	No	9	8
78	3x47	5x57	alpha_on	9.09074	37.946	No	No	No	No	9	6
79	3x51	5x57	alpha_on	7.96755	33.8419	No	Yes	No	No	8	6
80	3x51	3x52	alpha_on	0	15.6415	No	Yes	No	No	8	5
81	3x52	I2x53	alpha_on	4.44109	12.3757	No	No	No	Yes	5	7
82	2x46	7x49	alpha_on	0	16.5481	No	Yes	No	Yes	9	9
83	2x46	3x42	alpha_on	1.14232	17.3962	No	Yes	No	Yes	9	7
84	2x53	7x46	alpha_on	0	15.6999	No	No	No	No	8	9
85	2x56	7x42	alpha_on	0	24.7368	No	No	Yes	Yes	8	7
86	2x54	2x57	alpha_on	0	10.5527	No	No	Yes	No	7	8
87	2x60	7x42	alpha_on	1.12893	24.7612	No	No	Yes	Yes	7	7
88	2x60	3x28	alpha_on	0	23.606	No	No	Yes	Yes	7	5
89	6x51	7x34	alpha_on	0.417129	12.6682	Yes	Yes	No	No	7	4
90	E1x50	E1x52	alpha_on	7.84126	41.0363	Yes	Yes	No	No	8	5
91	E1x51	E1x52	alpha_on	0	20.6376	No	No	No	No	3	5
92	E1x49	E1x51	alpha_on	1.7087	12.4098	No	No	No	No	4	3
93	3x24	E1x52	alpha_on	0	16.5286	Yes	Yes	No	No	5	5
94	3x43	7x49	alpha_on	0	51.4866	No	No	No	Yes	8	9
95	3x43	7x53	alpha_on	0	50.8091	No	No	Yes	Yes	8	9
96	5x47	6x48	alpha_on	0	20.4133	Yes	Yes	Yes	Yes	8	8
97	5x58	6x37	alpha_on	0	32.906	Yes	Yes	No	No	9	0
98	5x62	6x37	alpha_on	0	31.278	No	Yes	No	No	5	0
99	5x62	6x33	alpha_on	0	26.009	No	Yes	No	No	5	0
100	6x30	6x33	alpha_on	0	22.5239	No	No	No	No	0	0
101	8x48	8x49	alpha_on	4.57503	20.077	No	No	Yes	Yes	5	7
102	8x48	8x51	alpha_on	2.29421	13.3116	No	No	No	No	5	8
103	5x58	6x40	alpha_on	0	18.293	Yes	Yes	No	No	9	8
104	5x47	6x49	alpha_on	1.75462	30.001	Yes	Yes	No	Yes	8	7
105	6x49	6x53	alpha_on	1.17294	20.3548	No	Yes	No	No	7	6
106	2x38	I2x57	alpha_on	0	10.7916	No	No	Yes	Yes	7	6
107	5x461	Lig	alpha_on	0	12.5512	No	No	Yes	Yes	6	0
108	3x37	5x461	alpha_on	1.42551	11.0158	No	No	No	No	7	6
109	6x53	6x57	alpha_on	0.587425	18.3418	No	No	No	No	6	5
110	5x69	6x30	alpha_on	0	20.657	No	No	No	No	5	0
111	3x51	5x61	alpha_on	0	11.6982	No	Yes	No	No	8	9
112	6x57	E3	alpha_on	0	16.319	No	No	Yes	Yes	5	3
113	1x36	2x65	alpha_on	0	11.7957	No	No	No	No	6	5
114	3x50	7x53	alpha_on	0	30.7126	No	No	Yes	Yes	9	9
115	6x40	7x53	alpha_on	0	17.8495	No	No	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x63	Lig	alpha_off	5.085	0	0	0	1	0
3x28	Lig	alpha_off	5.72	0	0	0	1	0
3x32	Lig	Shared	18.955	12.1633	1	1	1	0
3x33	Lig	Shared	7.74	9.23667	0	0	1	0
3x36	Lig	Shared	6.24	8.83833	0	1	1	0
5x43	Lig	Shared	4.165	2.93583	0	0	1	0
6x51	Lig	Shared	10.84	11.1692	1	1	1	0
6x52	Lig	Shared	6.05	3.65583	1	1	1	0
6x55	Lig	Shared	6.675	8.06333	1	1	1	0
7x38	Lig	Shared	16.33	15.45	1	1	1	0
7x42	Lig	Shared	5.015	7.4825	1	1	1	0
2x56	3x28	Shared	4.38	5.80833	0	1	2	1
2x56	3x32	Shared	4.38	7.39417	0	1	2	1
2x57	7x39	alpha_off	4.05	0	1	0	2	2
2x57	7x42	alpha_off	10.05	0	1	0	2	1
2x59	3x28	Shared	4.095	6.3625	0	0	2	1
2x63	E1x50	Shared	4.955	3.20167	0	0	1	2
3x28	E1x50	Shared	9.07	3.94	0	0	1	2
3x32	7x42	Shared	5.75	6.9	1	1	1	1
3x33	4x57	alpha_off	4.85	0	0	0	1	2
3x36	6x48	Shared	5.225	3.48083	0	1	1	1
3x37	4x57	alpha_off	4	0	0	0	2	2
3x37	5x461	Shared	7.995	6.39333	0	0	2	1
3x40	6x44	alpha_off	5.715	0	0	0	2	2
5x39	5x43	Shared	6.995	9.32667	2	3	2	1
5x40	6x55	Shared	8.775	8.6475	0	0	2	1
5x47	5x48	Shared	7.94	5.895	0	1	2	2
5x47	6x44	Shared	3.615	4.55583	0	1	2	2
5x47	6x52	Shared	18.22	20.7133	0	1	2	1
6x44	6x48	Shared	8.16	4.34333	0	1	2	1
6x48	6x51	alpha_off	4.51	0	1	1	1	1
6x48	6x52	Shared	4.51	7.185	1	1	1	1
6x48	7x41	Shared	9.15	6.09667	1	1	1	2
6x51	6x52	alpha_off	8.04	0	1	1	1	1
6x51	6x55	Shared	8.055	4.2125	1	1	1	1
6x51	7x34	Shared	4.82	5.89417	1	1	1	2
6x51	7x38	Shared	4.82	7.23167	1	1	1	1
7x34	7x38	alpha_off	3.75	0	1	0	2	1
7x35	7x38	alpha_off	3.72	0	0	0	2	1
7x39	7x42	Shared	10.61	5.4675	1	0	2	1
2x60	7x42	Shared	3.815	5.61667	0	0	2	1
6x44	7x45	alpha_off	5.65	0	0	1	2	2
5x44	6x52	alpha_off	3.48	0	0	1	2	1
E2x52	Lig	alpha_off	3.35	0	0	0	1	0
4x62	E2x52	alpha_off	1.49	0	0	0	2	1
2x56	7x42	alpha_on	0	4.12833	0	1	2	1
2x60	3x28	alpha_on	0	3.9225	0	0	2	1
3x40	6x48	alpha_on	0	8.905	0	0	2	1
6x55	E2x52	alpha_on	0	2.98333	1	1	1	1
5x48	6x52	alpha_on	0	3.12417	0	1	2	1
6x48	7x45	alpha_on	0	9.3225	1	1	1	2
6x48	Lig	alpha_on	0	4.32667	1	1	1	0
7x38	7x42	alpha_on	0	11.6033	1	1	1	1
5x461	Lig	alpha_on	0	4.16667	0	0	1	0
5x47	6x48	alpha_on	0	3.17333	0	1	2	1
5x44	5x48	alpha_on	0	3.455	0	1	2	2
5x44	6x55	alpha_on	0	2.9925	0	1	2	1
7x34	7x35	alpha_on	0	3.1675	1	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha_off	alpha1_off alpha2_off
	alpha_on	alpha1_on alpha2_on

Network Difference
Value	alpha_off	alpha_on
I_min	3.53	2.8675
Number of Linked Nodes	259	261
Number of Specific Nodes	9 (3.47%)	11 (4.21%)
Number of Shared Nodes	250 (96.53%)	250 (95.79%)
Number of Links	278	290
Number of Specific Links	127 (45.68%)	139 (47.93%)
Number of Shared Links	151 (54.32%)	151 (52.07%)
Number of Hubs	26	39
Number of Specific Hubs	6 (23.08%)	19 (48.72%)
Number of Shared Hubs	20 (76.92%)	20 (51.28%)
Average % Shared Neighbours (Jaccard)	38.55
Average % Shared Neighbours (Otsuka)	48.34
Average % Shared Neighbours (Overlap Coefficient)	58.80
Average % Shared Cliques (k3-6)	80.36
Graphlets Similarity	0.539874

Paths Difference
Value	alpha_off	alpha_on
Number Of Nodes in MetaPath	46	76
Specific Nodes in MetaPath	16 (34.78%)	46 (60.53%)
Shared Nodes in MetaPath	250 (96.53%)	250 (96.53%)
Number Of Links MetaPath	50	82
Specific Links in MetaPath	33 (66.00%)	65 (79.27%)
Shared Links in MetaPath	151 (54.32%)	151 (54.32%)
Number of Shortest Paths	84168	53517
Length Of Smallest Path	3	3
Average Path Length	13.8219	12.7482
Length of Longest Path	28	27
Minimum Path Strength	0.7625	0.323333
Average Path Strength	5.54152	5.23513
Maximum Path Strength	17.6425	14.6042
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.912763	0.919806
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.54545	4.54545
Average % Of Corr. Nodes	40.7013	45.8683
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.5804	45.2693
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download alpha_off_on.zip<

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