Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.72417402
2G.S1.02 5.340834185
3G.S1.04 4.6954187
4G.S1.05 6.20067519
5G.s1h1.05 4.14254139
6G.H1.01 6.498334139
7G.H1.04 4.31754117
8G.S2.08 8.831674195
9G.S3.01 5.22917404
10G.S3.03 8.861335187
11G.S3.05 3.45583407
12G.S3.06 8.26867515
13G.S3.07 4.238334139
14G.S3.08 4.6825419
15G.H2.03 7.27133519
16G.H2.06 5.99542819
17G.H2.07 5.19833619
18G.H2.08 3.92167418
19G.H2.09 6.75833418
20G.h2s4.01 7.17722619
21G.s4h3.02 4.5375409
22G.s4h3.04 9.881335108
23G.H3.01 3.66333409
24G.H3.03 4.04417404
25G.H3.06 5.49417496
26G.H3.09 6.31778699
27G.H3.17 7.20611615
28G.H3.18 6.06583419
29G.S5.04 5.18499
30G.S5.06 6.405498
31G.S5.07 4.765834119
32G.HG.01 4.09833405
33G.HG.04 6.83917409
34G.HG.13 5.458334107
35G.HG.14 3.834174105
36G.hgh4.02 6.87733597
37G.hgh4.05 6.17417407
38G.H4.15 5.04556698
39G.S6.02 6.37889687
40G.S6.04 10.30174119
41G.H5.03 4.9154118
42G.H5.08 5.838675198
43G.H5.13 6.58417488
44G.H5.17 5.205685
45G.H5.25 4.98407
46G.H5.26 6.828585
47g.l1x4 4.41267558
48g.h2x7 2.954205
49g.h2x11 9.58436
50g.ctx3 6.22889639
51g.ctx5 4.20333439
52g.ctx6 3.62389636
53g.ctx15 8.2725449
54g.ctx16 4.95542848
551x39 6.66267526
56I1x50 6.914174128
572x46 4.95467529
582x49 4.2475428
592x50 6.48429
602x56 6.41667427
612x57 5.26533527
62E1x49 5.78167403
63E1x50 5.672387158
643x28 6.65083405
653x32 9.62833428
663x37 4.0025427
673x38 8.05333428
683x41 7.20667405
693x42 6.62628
703x50 7.31429
713x51 7.46133508
723x52 8.42333404
73I2x53 9.871335147
74I2x55 4.33583404
75I2x57 7.029335147
76E2.H177 4.656505
775x39 5.486675227
785x47 8.39333628
795x48 5.08917425
805x58 4.98222629
815x62 3.9925405
826x37 3.97667408
836x44 4.45083429
846x48 6.06111928
856x49 4.58417406
866x51 8.765427
876x52 11.2883427
886x54 4.9725405
897x39 9.14167626
907x42 6.7281727
917x49 6.87533529
927x53 5.60933529
938x47 5.34254129
948x48 4.653334125
958x49 5.0545127
968x50 7.652226128
97Lig 8.471941220
98b.1x4 3.622508
99b.1x19 4.46667453
100b.lhb1x6 4.45667533
101b.b1x4 3.1875447
102b.b1x6 7.146549
103b.l1x3 9.14555649
104b.b2x1 9.10944618
105b.b2x3 4.12417446
106b.b2x5 6.47278647
107b.b3x2 6.11167445
108b.b3x3 3.674568
109b.l3x2 5.31533549
110b.b4x3 5.105467
111b.b4x6 10.9194649
112b.b5x2 5.7925407
113b.b5x3 8.21533549
114b.b5x5 6.04167465
115b.b5x7 6.42333407
116b.l5x1 4.61867568
117b.l5x5 9.76667619
118b.b6x5 4.27667766
119b.l6x5 7.579174214
120b.b7x1 6.1325214
121b.l7x5 4.94466
122b.b8x4 5.70667566
123b.l8x5 3.935463
124b.l8x10 5.16917464
125b.b9x3 7.605466
126b.l9x6 5.31042818
127b.b10x5 4.90667509
128b.l10x1 4.48417473
129b.b11x1 4.658505
130b.b11x4 5.996674169
131b.b12x3 4.11833478
132b.b12x5 4.104576
133b.b12x6 9.609446168
134b.b12x7 6.1325409
135b.b13x7 7.23577
136b.l13x3 8.45833679
137b.l13x6 6.314519
138b.l13x7 5.26083479
139b.b14x1 5.52417418
140b.b15x1 7.67667479
141b.b15x2 7.564556
142b.b15x3 4.92833479
143b.l15x1 5.522517
144b.l15x2 6.1825479
145b.b16x4 9.85667576
146b.b16x5 6.178505
147b.b16x6 9.35111678
148b.b17x5 8.145457
149b.b17x7 9.15333458
150b.l17x3 9.3181759
151b.l17x6 5.91389619
152b.b18x3 5.68833458
153b.b18x5 6.90333455
154b.l18x1 6.46875836
155b.l18x2 6.15437
156b.b19x2 8.16667656
157b.b19x4 6.2475458
158b.l19x1 6.1825419
159b.l19x2 7.96917459
160b.b20x4 9.362558
161b.b20x6 7.56656
162b.b20x7 4.40833409
163b.l20x2 6.957335209
164b.b21x1 7.94278657
165b.b21x5 6.27667404
166b.b21x7 7.50133505
167b.b22x5 6.07267537
168b.l22x5 7.78933539
169b.b23x6 8.022675177
170b.b24x4 7.343335176
171b.b24x6 7.245834178
172b.l24x2 6.76667436
173b.b25x3 6.24175
174b.l25x3 8.88267539
175b.l25x6 11.4992418
176b.b26x3 3.98406
177b.b27x1 5.09917406
178b.l27x1 11.8019719
179b.l27x2 6.835439
180b.b28x2 7.58404
181b.b28x3 4.49333407
182b.b28x4 6.96933536
183b.b28x6 8.84867539
1845x69 3.99417480
1855x72 3.76933580
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x3 b.l2x5 18.16843.17333NoNo085
2b.b3x1 b.l2x3 18.12784.97667NoNo058
3b.b3x1 b.b6x5 18.09525.07667NoYes056
4b.b3x3 b.b6x5 10.25944.20667YesYes686
5b.l2x5 b.l4x2 18.983322.6333NoNo054
6b.l4x2 g.ctx16 12.65757.22NoYes448
7b.b28x5 g.ctx16 35.08216.27667NoYes458
8b.b1x6 b.b28x5 35.16924.75667YesNo495
9b.b1x6 b.b4x6 35.130115.9433YesYes499
10b.b4x6 b.b5x3 57.128111.9867YesYes499
11G.HN.44 b.b5x3 57.470711.06NoYes069
12G.HN.44 G.HN.48 57.39481.98333NoNo063
13G.HN.48 G.HN.52 57.01470.386667NoNo034
14G.HN.52 G.hns1.03 56.9420.386667NoNo044
15G.hns1.03 I2x55 56.819712.7933NoYes044
16b.b2x4 b.b6x5 16.59653.27NoYes066
17b.b10x4 b.b2x4 16.578714.2933NoNo066
18b.b10x2 b.b10x4 16.57196.49667NoNo066
19b.b10x2 b.b14x3 16.57234.23333NoNo065
20b.b11x5 b.b14x3 16.5798.00667NoNo065
21b.b10x1 b.b11x5 31.21683.80333NoNo096
22b.b10x1 b.l9x6 31.35492.96667NoYes098
23G.H2.07 b.l9x6 39.55763.53667YesYes198
24G.S3.01 I2x55 56.70012.83333YesYes044
25G.S3.01 G.S3.03 55.14419.33667YesYes047
26G.S1.04 G.S3.03 75.53624.87YesYes1877
27G.S1.04 G.S3.05 27.40023.29667YesYes077
28G.S2.06 G.S3.03 30.23613.93NoYes097
29G.S2.06 G.S3.05 27.7733.31667NoYes097
30G.S1.04 G.S4.03 1007.13667YesNo077
31G.H2.07 G.H2.08 44.93053.13YesYes198
32G.H1.04 G.S5.07 52.99786.61YesYes1179
33G.H1.04 G.H1.08 55.05183.40333YesNo078
34G.H1.08 G.S2.06 54.98996.22NoNo089
35G.H2.04 G.H2.08 52.79423.76NoYes098
36G.H2.04 G.H3.08 52.984.86NoNo099
37G.H2.08 G.H3.15 10.56153.77667YesNo188
38G.H3.15 G.H3.17 10.55234.14333NoYes185
39G.S4.03 G.S5.03 99.77883.43333NoNo078
40G.H3.08 G.S4.04 53.08036.09333NoNo099
41G.H3.09 G.S4.04 53.178516.0767YesNo099
42G.H3.09 G.H4.15 28.03933.93YesYes998
43G.S5.07 G.s5hg.01 53.74322.79667YesNo099
44G.s4h3.02 G.s5hg.01 53.73555.61YesNo099
45G.H3.09 G.S5.04 26.26174.87333YesYes999
46G.S5.04 G.S5.06 26.36043.69YesYes998
47G.H4.15 G.S5.06 26.3923.25YesYes988
48G.S5.06 G.s4h3.01 51.410810.1533YesNo087
49G.HG.04 G.s4h3.01 51.310310.9633YesNo097
50G.HG.07 G.s4h3.02 53.81984.59NoYes099
51G.HG.04 G.s4h3.04 51.23958.59667YesYes098
52G.HG.07 G.s4h3.04 53.08616.37NoYes1098
53G.H5.10 G.S5.03 99.33573.79NoNo068
54G.H5.10 G.S6.02 99.11385.33667NoYes067
55G.H5.17 G.S6.02 95.39433.58333YesYes857
56G.H5.17 G.H5.26 93.93828.27333YesYes855
573x47 5x57 11.45213.15NoNo085
583x47 5x58 11.74944.89333NoYes089
595x58 6x37 81.70723.51667YesYes098
606x37 G.H5.25 81.828.3YesYes087
61G.H5.20 G.H5.25 83.93174.61333NoYes097
62G.H5.20 G.H5.26 84.63225.68667NoYes095
63b.b11x5 b.l13x7 35.3544.85NoYes069
64b.l13x3 b.l13x7 11.34177.84333YesYes799
65b.l26x5 g.ctx15 29.60037.82667NoYes059
66b.l26x5 g.ctx4 52.37835.03NoNo057
67g.ctx3 g.ctx4 52.27183.22YesNo097
68g.ctx3 g.ctx6 44.28898.14333YesYes396
69b.l22x5 g.ctx6 42.53324.86YesYes396
70b.l22x5 g.h2x12 26.52533.25YesNo397
71b.l18x1 g.h2x12 26.46653.72333YesNo367
72b.l18x1 b.l18x3 11.31186.04333YesNo365
73b.l18x3 b.l18x5 11.2527.26333NoNo052
74b.l18x5 b.l20x2 11.157612.4533NoYes029
75b.b20x7 b.l20x2 10.79083.96667YesYes099
76b.b20x7 b.b21x4 10.62025.43YesNo095
77b.b21x4 g.h2x1 31.3812.98NoNo058
78b.b21x2 g.h2x1 30.99463.82333NoNo068
79b.1x19 b.b21x2 30.23453.50333YesNo036
80b.1x19 b.b21x1 23.15268.33667YesYes537
81b.b22x5 b.l18x1 14.4679.29YesYes376
82b.b22x5 b.b23x2 14.42889.74667YesNo376
83b.b21x7 b.b23x2 14.41055.86333YesNo056
84b.b20x5 b.b21x7 22.10177.42333NoYes075
85b.b20x5 b.b21x4 21.8283.69NoNo075
86b.l22x5 b.l24x2 16.080610.1233YesYes396
87b.h2x5 b.l24x2 15.25068.35333NoYes356
88b.h2x1 b.h2x5 15.42053.93333NoNo055
89b.b21x5 b.h2x1 15.33996.12333YesNo045
90b.b21x5 b.b21x7 14.51479.58YesYes045
91g.ctx3 g.ctx5 17.26174.07YesYes399
92b.lhb1x11 g.ctx5 11.11423.76667NoYes349
936x48 Lig 26.46413.11667YesYes280
946x48 7x45 36.17210.9233YesNo289
957x45 7x49 36.7099.08NoYes299
967x49 7x53 53.1383.87333YesYes299
975x58 7x53 64.42843.31YesYes299
982x50 7x49 11.22244.49YesYes299
99b.b28x6 b.lhb1x11 10.65353.10333YesNo394
1002x46 3x42 20.06577.28333YesYes298
1012x46 3x46 10.57573.32667YesNo299
102b.b2x5 b.b3x2 22.933510.25YesYes475
103b.l26x3 b.l26x5 23.15036.46667NoNo075
104b.l26x1 b.l26x3 23.00927.23NoNo477
105b.b2x5 b.l26x1 23.08110.9167YesNo477
106b.l11x1 b.l9x6 13.32924.35NoYes198
107b.b11x6 b.l11x1 13.08983.71NoNo099
108b.b11x6 b.l9x3 10.809716.2733NoNo099
109b.b12x3 b.l13x7 20.00675.12YesYes789
110b.b12x3 b.b13x7 10.91953.72333YesYes787
111b.b13x5 b.b13x7 11.10225.62333NoYes747
112b.b11x1 b.b12x5 15.45296.21YesYes056
113b.b11x1 b.l16x2 13.98313.50667YesNo059
114b.l14x5 b.l16x2 13.48289.24NoNo059
115b.l14x3 b.l14x5 13.10935.56NoNo055
116b.l14x1 b.l14x3 12.73793.09NoNo045
117b.b18x5 b.l14x1 11.64585.54667YesNo054
118b.b17x7 b.b21x1 12.65355.97333YesYes587
119g.ctx15 g.ctx16 23.2515.29667YesYes498
120b.b3x2 b.b4x6 23.03087.21YesYes459
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x3211.68672YesYes7821
2x567x425.052YesYes7721
2x577x396.206672YesYes7622
2x577x424.392YesYes7721
2x607x397.826672NoYes6622
2x607x423.816672NoYes6721
3x323x363.633332YesNo8711
3x327x428.812YesYes8711
3x32Lig14.38332YesYes8010
3x334x575.623330NoNo7712
3x335x393.190NoYes7712
3x33Lig17.72330NoYes7010
3x366x485.656672NoYes7811
3x36Lig6.582NoYes7010
3x374x535.866672YesNo7812
3x374x563.042YesNo7612
3x375x4613.913332YesNo7611
3x37Lig3.192YesYes7010
3x406x488.613330NoYes8821
6x55E2.H1774.923332NoYes6012
5x395x436.3633322YesNo7721
5x43Lig3.390NoYes7010
5x446x526.922NoYes7721
5x461Lig3.036672NoYes6010
5x476x445.716672YesYes8922
5x476x483.676672YesYes8821
5x476x5223.222YesYes8721
6x446x483.006672YesYes9821
6x477x458.443332NoNo7922
6x486x527.352YesYes8711
6x487x418.912YesNo8612
6x487x4510.92332YesNo8912
6x48Lig3.116672YesYes8010
6x516x546.616672YesYes7512
6x516x558.162YesNo7611
6x517x384.753332YesNo7412
6x51Lig15.532YesYes7010
6x52Lig7.663332YesYes7010
6x55Lig12.01672NoYes6010
7x387x424.993330NoYes4721
7x397x4214.792YesYes6721
7x42Lig5.246672YesYes7010
E2x52Lig9.786670NoYes5010
E2.H177E2x525.303330YesNo0521
6x476x483.296672NoYes7821

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
100.00Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
92.31Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
92.31Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
92.31Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
91.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
91.67Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
91.67Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
85.71Single3D4STimolol3D4S-β2-Timolol
85.71Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
84.62Single2RH1S-Carazolol2RH1-β2-S-Carazolol
84.62Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
84.62Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
84.62Consensusamine_offonOrthosteric Ligandamine_off amine_on
84.62Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
84.62Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
84.62Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
84.62Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
84.62Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
83.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
83.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
83.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
83.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
83.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
83.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
78.57Single5D5AS-Carazolol5D5A-β2-S-Carazolol
78.57Single5D5BS-Carazolol5D5B-β2-S-Carazolol
78.57Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
78.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
78.57Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
78.57Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
78.57Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
76.92Single3NY8ICI118-5513NY8-β2-ICI118-551
76.92Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
76.92Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
76.92Single4GBRS-Carazolol4GBR-β2-S-Carazolol
76.92Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
76.92Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
76.92Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
76.92Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
76.92Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
76.92Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
76.92Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
76.92Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
76.92Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
76.92Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
76.92Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
76.92Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
76.92Single8JJOAlprenolol8JJO-β2-Alprenolol
76.92Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
76.92Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8X64Desloratadine8X64-H1-Desloratadine
76.92Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
76.92Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
76.92Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
76.92Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
76.92Consensusalpha2_onOrthosteric Ligandalpha2b_on
76.92Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
76.92Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
76.92Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
76.92Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
76.92Consensusdopamine_offOrthosteric Ligandd2_off d3_off
76.92Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
76.92Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
75.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
75.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
75.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
75.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
75.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
75.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
75.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
75.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
73.33Single4AMIBucindolol4AMI-β1-Bucindolol
73.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
73.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
73.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
73.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
73.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
73.33Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
73.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
73.33Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
71.43Single2YCWS-Carazolol2YCW-β1-S-Carazolol
71.43Single5D6LS-Carazolol5D6L-β2-S-Carazolol
71.43Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
71.43Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
71.43Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
71.43Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
71.43Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
71.43Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
71.43Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
71.43Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
71.43Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
71.43Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
71.43Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
71.43Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
71.43Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
71.43Consensustrace-amine_onOrthosteric Ligandta1_on
70.59Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
69.23Single3RZECidoxepin3RZE-H1-Cidoxepin
69.23Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
69.23Single6A94Zotepine6A94-5-HT2A-Zotepine
69.23Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
69.23Single6PS0S-Carazolol6PS0-β2-S-Carazolol
69.23Single6PS4ICI118-5516PS4-β2-ICI118-551
69.23Single6PS5S-Propranolol6PS5-β2-S-Propranolol
69.23Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
69.23Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
69.23Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
69.23Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
69.23Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
69.23Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
69.23Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
69.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
69.23Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
69.23Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
69.23Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
69.23Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
69.23Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
69.23Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
69.23Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
69.23Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
69.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
69.23Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
69.23Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
69.23Consensusalpha1_onOrthosteric Ligandalpha1a_on
69.23Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
69.23Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
69.23Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
68.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
68.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
68.75Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
68.75Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
68.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
66.67Single2YDVNECA2YDV-A2A-NECA
66.67Single3PBLEticlopride3PBL-D3-Eticlopride
66.67Single4U15Tiotropium4U15-M3-Tiotropium
66.67Single4UHRCGS216804UHR-A2A-CGS21680
66.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
66.67Single5G53NECA5G53-A2A-NECA-Gs
66.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
66.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
66.67Single6J21Aprepitant6J21-NK1-Aprepitant
66.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
66.67Single6OL9Tiotropium6OL9-M5-Tiotropium
66.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
66.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
66.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
66.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
66.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
66.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
66.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
66.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
66.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
66.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
66.67Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
66.67Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
66.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
66.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
66.67Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
66.67Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
66.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
66.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
66.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
66.67Consensustachykinin_offOrthosteric Ligandnk1_off
64.71Single3NY9ICI118-5513NY9-β2-ICI118-551
64.71Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
64.71Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
64.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
64.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
64.29Single6H7MSalbutamol6H7M-β1-Salbutamol
64.29Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
64.29Single6PS1Timolol6PS1-β2-Timolol
64.29Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
64.29Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
64.29Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
64.29Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
64.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
64.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
64.29Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
64.29Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
64.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
64.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
64.29Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
64.29Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
64.29Single9CHXS-Carazolol9CHX-β2-S-Carazolol
64.29Consensus5ht5_onOrthosteric Ligand5ht5a_on
64.29Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
64.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
64.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
64.29Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
62.50Single4LDEBI1671074LDE-β2-BI167107
62.50Single5CXVTiotropium5CXV-M1-Tiotropium
62.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
62.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
62.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
62.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
62.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
62.50Single8JJ8Formoterol8JJ8-β2-Formoterol
62.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
62.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
62.50Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
62.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
61.54Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
61.54Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
61.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
61.54Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
61.54Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
61.54Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
61.54Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
61.54Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
61.54Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
61.54Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
61.54Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
61.54Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
61.54Consensusalpha2_offOrthosteric Ligandalpha2c_off
61.54Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.54Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.54Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
61.54Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
61.11Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
61.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
61.11Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
60.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
60.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
60.00Single5WIUNemonapride5WIU-D4-Nemonapride
60.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
60.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
60.00Single6PS6Timolol6PS6-β2-Timolol
60.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
60.00Single7WC6LSD7WC6-5-HT2A-LSD
60.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
60.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
60.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
60.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
60.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
60.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
60.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
60.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
60.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.82Single6H7LDobutamine6H7L-β1-Dobutamine
58.82Single6IBLArformoterol6IBL-β1-Arformoterol
58.82Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
58.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
58.82Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
58.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
58.82Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
58.82Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
58.82Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
58.33Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
58.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
58.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
58.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
58.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
58.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
57.14Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
57.14Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
57.14Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
57.14Single6TPNHTL66416TPN-OX2-HTL6641
57.14Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
57.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
57.14Single7UL3Famotidine7UL3-H2-Famotidine
57.14Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
57.14Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
57.14Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
57.14Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
57.14Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
57.14Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
57.14Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
57.14Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
57.14Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
57.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
57.14Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
57.14Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
57.14Single9BJKNaloxone9BJK-μ-Naloxone-NAM
57.14Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
57.14Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
56.25Single3P0GBI1671073P0G-β2-BI167107
56.25Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
56.25Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
56.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
56.25Single6J20Aprepitant6J20-NK1-Aprepitant
56.25Single6TQ7SB-3348676TQ7-OX1-SB-334867
56.25Single6WGTLSD6WGT-5-HT2A-LSD
56.25Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
56.25Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
56.25Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
56.25Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
56.25Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
56.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
56.25Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
56.25Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
56.25Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
56.25Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
55.56Single4UG2CGS216804UG2-A2A-CGS21680
55.56Single8X5YAstemizole8X5Y-H1-Astemizole
53.85Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
53.85Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
53.85Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
53.85Single7SRQLSD7SRQ-5-HT2B-LSD
53.85Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
53.85Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
53.85Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
53.85Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
53.85Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
53.85Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.85Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
53.85Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.85Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
53.33Single2Y02Carmoterol2Y02-β1-Carmoterol
53.33Single2Y04Salbutamol2Y04-β1-Salbutamol
53.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.33Single4MQSIperoxo4MQS-M2-Iperoxo
53.33Single4QKX35V4QKX-β2-35V
53.33Single4U14Tiotropium4U14-M3-Tiotropium
53.33Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
53.33Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
53.33Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
53.33Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
53.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single7BU7BI1671077BU7-β1-BI167107
53.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
53.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
53.33Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
53.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
53.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
53.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
53.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
53.33Single8JXRLSD8JXR-D1-LSD
53.33Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
53.33Single8X63Mepyramine8X63-H1-Mepyramine
53.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
53.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
53.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
53.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.33Consensushistamine_offOrthosteric Ligandh1_off
53.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
53.33Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
52.94Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
52.94Single6MXTSalmeterol6MXT-β2-Salmeterol
52.94Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
52.94Single7YITNalfurafine7YIT-κ-Nalfurafine
52.94Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
52.94Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
52.94Consensusalpha1_offOrthosteric Ligandalpha1a_off
52.94Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
52.94Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
52.94Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
52.94Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.94Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.94Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
52.63Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
52.63Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
52.63Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
52.63Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
52.63Single8WDTphotoNECA8WDT-A2A-photoNECA
52.63Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
50.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
50.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
50.00Single5C1MBU725C1M-μ-BU72
50.00Single5TVNLSD5TVN-5-HT2B-LSD
50.00Single5X93K-87945X93-ETB-K-8794
50.00Single6B73MP11046B73-κ-MP1104
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
50.00Single6HLOAprepitant6HLO-NK1-Aprepitant
50.00Single6HLPNetupitant6HLP-NK1-Netupitant
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
50.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
50.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
50.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
50.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
50.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
50.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
50.00Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
50.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
50.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
50.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
50.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
50.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
50.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
50.00Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
50.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
50.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
50.00Consensussensory_onOrthosteric Ligandopsins_on
47.62Single5WF5UK-4320975WF5-A2A-UK-432097
47.62Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
47.37Single6PT3DPI-2876PT3-δ-DPI-287
47.37Single7SK9CCX6627SK9-ACKR3-CCX662
47.06Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
47.06Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
47.06Single6E59L-7607356E59-NK1-L-760735
47.06Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
47.06Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
47.06Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
47.06Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
47.06Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
47.06Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
47.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
47.06Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
47.06Single8E0GBU728E0G-μ-BU72
47.06Single8EA0Iperoxo8EA0-M3-Iperoxo
47.06Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
47.06Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
47.06Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
47.06Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
47.06Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
47.06Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
47.06Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
47.06Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
47.06Single8XVLZibotentan8XVL-ETA-Zibotentan
47.06Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
47.06Consensusa2_onOrthosteric Liganda2b_on
47.06Consensusa2_on_gpOrthosteric Liganda2b_on_gp
47.06Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
47.06Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
47.06Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.06Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
47.06Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
47.06Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
46.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
46.67Single2YDOAdenosine2YDO-A2A-Adenosine
46.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
46.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
46.67Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
46.67Single6KUXRS-799486KUX-α2a-RS-79948
46.67Single6TPGEMPA6TPG-OX2-EMPA
46.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
46.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
46.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
46.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
46.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
46.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
46.67Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
46.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
46.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
46.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
46.67Consensussensory_offOrthosteric Ligandopsins_off
46.15Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
46.15Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
46.15Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
46.15Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
46.15Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.15Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.15Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
45.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
44.44Single4RWADIPP-NH24RWA-δ-DIPP-NH2
44.44Single6CM4Risperidone6CM4-D2-Risperidone
44.44Single6ZG4HTL00099366ZG4-M1-HTL0009936
44.44Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
44.44Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
44.44Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
44.44Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
44.44Single8JJLOlodaterol8JJL-β2-Olodaterol
44.44Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
43.75Single2Y01Dobutamine2Y01-β1-Dobutamine
43.75Single4DAJTiotropium4DAJ-M3-Tiotropium
43.75Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
43.75Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
43.75Single5DHGC-355DHG-NOP-C-35
43.75Single5DSGTiotropium5DSG-M4-Tiotropium
43.75Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
43.75Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
43.75Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
43.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
43.75Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
43.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
43.75Single7UL4Alvimopan7UL4-μ-Alvimopan
43.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
43.75Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
43.75Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
43.75Single8T1WCVN4248T1W-GPR6-CVN424
43.75Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
43.75Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
43.75Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
43.75Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
43.75Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
42.86Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
42.86Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
42.86Single3QAKUK-4320973QAK-A2A-UK-432097
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
42.86Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
42.86Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
42.86Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
42.86Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
42.86Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
42.86Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
42.86Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
42.86Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.86Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
42.11Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
42.11Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
42.11Single7EZCUKA7EZC-A2A-UKA
42.11Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
42.11Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
42.11Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
41.67Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
41.67Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
41.18Single2Y00Dobutamine2Y00-β1-Dobutamine
41.18Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
41.18Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
41.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
41.18Single5WQCEMPA5WQC-OX2-EMPA
41.18Single5XPRBosentan5XPR-ETB-Bosentan
41.18Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
41.18Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
41.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
41.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
41.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
41.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
41.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
41.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
41.18Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
41.18Single8JXSPF-61428JXS-D1-PF-6142
41.18Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
41.18Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Consensusa3_on_gpOrthosteric Liganda3a_on_gp
41.18Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
41.18Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
41.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
41.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
40.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single6TODEMPA6TOD-OX1-EMPA-Na
40.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
40.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
40.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
40.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
40.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
40.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
40.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
40.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
40.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
40.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
40.00Single8IWESpermidine8IWE-TA9-Spermidine
40.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
40.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
40.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
40.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
40.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
40.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
38.89Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
38.89Single4DJHJDTic4DJH-κ-JDTic
38.89Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.89Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
38.89Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
38.89Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.89Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
38.89Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
38.89Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.89Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
38.89Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
38.46Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
38.46Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
38.46Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
38.46Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
38.46Single9CHUNoradrenaline9CHU-β2-Noradrenaline
38.10Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.10Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
37.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
37.50Single4ZJCSB-6740424ZJC-OX1-SB-674042
37.50Single6IQLL7458706IQL-D4-L745870
37.50Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
37.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
37.50Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
37.50Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
37.50Single6VI4JDTic6VI4-κ-JDTic
37.50Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
37.50Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
37.50Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
37.50Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
37.50Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
37.50Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
36.84Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
36.84Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
36.84Single8JWY2-1188JWY-A2A-2-118
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
36.84Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
36.84Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
36.84Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
36.84Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
36.84Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.36Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
35.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
35.71Single3UZAGTPL92363UZA-A2A-GTPL9236
35.71Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
35.71Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
35.71Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
35.71Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
35.71Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
35.71Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
35.71Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
35.71Consensus5ht2_onOrthosteric Ligand5ht2b_on
35.71Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
35.71Consensusgi_sensoryOrthosteric Ligandgi_opsins
35.71Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
35.71Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
35.71Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
35.71Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
35.29Single5DHHSB-6121115DHH-NOP-SB-612111
35.29Single6DRXLisuride6DRX-5-HT2B-Lisuride
35.29Single6TOTLemborexant6TOT-OX1-Lemborexant
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
35.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.29Single8CU6LJ-45178CU6-A2A-LJ-4517
35.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
35.29Single8RLNLUF58348RLN-A2A-LUF5834
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
35.29Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
35.29Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
35.29Consensusa3_onOrthosteric Liganda3a_on
35.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt_onOrthosteric Ligandblt1_on
35.29Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
35.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusleukotriene_onOrthosteric Ligandblt_on
35.29Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
35.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
35.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
35.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
35.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
35.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
35.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
35.00Single8XVJMacitentan8XVJ-ETA-Macitentan
35.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
35.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
35.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
34.78Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
34.78Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
33.33Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
33.33Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
33.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
33.33Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6TP4ACT-4622066TP4-OX1-ACT-462206
33.33Single6TP6Filorexant6TP6-OX1-Filorexant
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7XN9L-054,5227XN9-SST2-L-054,522
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
33.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
33.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
33.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
33.33Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
33.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
33.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
33.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.14Consensusbombesin_onOrthosteric Ligandbb2_on
32.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.00Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
32.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
31.82Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
31.82Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
31.82Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
31.82Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
31.82Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
31.58Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
31.58Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
31.58Single7B6WCyclazosin7B6W-α1b-Cyclazosin
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
31.58Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
31.58Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.25Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
31.25Single5WS3EMPA5WS3-OX2-EMPA
31.25Single6AKYMaraviroc6AKY-CCR5-Maraviroc
31.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.25Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
31.25Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single8Y0HVUF114188Y0H-CXCR3-VUF11418
31.25Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
31.25Consensusorexin_offOrthosteric Ligandox2_off ox1_off
31.25Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
31.25Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
30.77Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
30.43Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
30.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
30.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
30.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
30.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
30.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
30.00Single8XYIVUF106618XYI-CXCR3-VUF10661
30.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
30.00Consensuslpa_offOrthosteric Ligandlpa1_off
30.00Consensusorexin_onOrthosteric Ligandox2_on
30.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
29.63Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
29.63Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
29.63Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
29.41Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.41Single5JTBZM-2413855JTB-A2A-ZM-241385
29.41Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
29.41Single5UVIZM-2413855UVI-A2A-ZM-241385
29.41Single6AQFZM-2413856AQF-A2A-ZM-241385
29.41Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
29.41Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.41Single6TPKRetosiban6TPK-OT-Retosiban
29.41Single6V9SGTPL114036V9S-OX1-GTPL11403
29.41Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.41Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
29.41Single7T32ZM-2413857T32-A2A-ZM-241385
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
29.41Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.41Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
29.41Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.41Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
29.41Consensusvasop-oxy_offOrthosteric Ligandot_off
29.17Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
29.17Consensusangiotensin_onOrthosteric Ligandat1_on
29.17Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.17Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
29.17Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
29.17Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
29.17Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
28.57Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
28.57Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensuschemerin_onOrthosteric Ligandcml1_on
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
28.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
28.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
27.78Single3EMLZM-2413853EML-A2A-ZM-241385
27.78Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
27.78Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
27.78Single5UIGCmpd-15UIG-A2A-Cmpd-1
27.78Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
27.78Single6S0LZM-2413856S0L-A2A-ZM-241385
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
27.78Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
27.78Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9IYAONO-97105319IYA-GPR55-ONO-9710531
27.78Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
27.78Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
27.27Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
27.27Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
27.27Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
27.27Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.27Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.92Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
26.92Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.92Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
26.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
26.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
26.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
26.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
26.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
26.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.32Single4NTJAZD12834NTJ-P2Y12-AZD1283
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.32Single5N2SPSB365N2S-A1-PSB36
26.32Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.32Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.32Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.32Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
26.32Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
26.32Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.32Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
26.32Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.32Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.32Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.32Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.32Single8S4DCMF-0198S4D-Apelin-CMF-019
26.32Single8TF5Oleic acid8TF5-GPR6-Oleic acid
26.32Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
26.32Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.09Single7F8XNN90567F8X-CCKA-NN9056
26.09Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.09Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
26.09Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
26.09Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.09Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
26.09Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.09Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.09Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.09Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
26.09Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.09Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.93Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.93Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.93Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
25.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
25.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
25.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
25.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
25.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
25.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
25.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
25.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
25.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
25.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
25.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
24.14Single6IGLIRL16206IGL-ETB-IRL1620
24.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on
24.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
24.14Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
24.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
24.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
24.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
24.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
24.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
24.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.81Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.81Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
23.81Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
23.81Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.81Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.53Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
23.53Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
23.53Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
23.53Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
23.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
23.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.53Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
23.53Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
23.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.53Single7F8ULintitript7F8U-CCKA-Lintitript
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7XRRLemborexant7XRR-OX2-Lemborexant
23.53Single8GNGIstradefylline8GNG-A2A-Istradefylline
23.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
23.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.53Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
23.53Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
23.53Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.53Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
23.53Consensusangiotensin_offOrthosteric Ligandat1_off
23.53Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.53Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
23.53Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.53Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
23.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.08Single5MZPCaffeine5MZP-A2A-Caffeine-Na
23.08Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.08Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.08Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
23.08Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
23.08Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.08Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
23.08Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
22.73Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
22.73Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
22.73Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
22.73Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
22.73Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
22.73Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
22.73Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
22.73Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
22.73Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.73Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.73Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusprostanoid_offOrthosteric Ligandep_off dp_off
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.22Single3REYXAC3REY-A2A-XAC
22.22Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
22.22Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
22.22Single5IUBQ274563445IUB-A2A-Q27456344-Na
22.22Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
22.22Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
22.22Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
22.22Single6FFIMMPEP6FFI-mGlu5-MMPEP
22.22Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.22Single6MH8ZM-2413856MH8-A2A-ZM-241385
22.22Single6TP3Nemorexant6TP3-OX1-Nemorexant
22.22Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7AROLUF58337ARO-A2A-LUF5833-Na
22.22Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
22.22Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
22.22Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
22.22Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
22.22Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
22.22Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
22.22Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
22.22Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
22.22Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8K5CAcipimox8K5C-HCA2-Acipimox
22.22Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
22.22Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
22.22Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
22.22Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
22.22Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
22.22Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8ZRTET-18ZRT-ETB-ET-1
22.22Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
22.22Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensushca_onOrthosteric Ligandhca2_on
21.88Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
21.88Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
21.74Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.74Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
21.74Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
21.74Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
21.74Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
21.74Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_onOrthosteric Ligandkiss1_on
21.43Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.43Single7WC4Serotonin7WC4-5-HT2A-Serotonin
21.43Single8PWNTheophylline8PWN-A2A-Theophylline
21.43Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
21.43Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.43Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.05Single4YAYZD-71554YAY-AT1-ZD-7155
21.05Single5TGZAM65385TGZ-CB1-AM6538
21.05Single5UENDU1725UEN-A1-DU172
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6FFHFenobam6FFH-mGlu5-Fenobam
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
21.05Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
21.05Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
21.05Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
21.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
21.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.05Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
21.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.05Single8K5DGSK2560738K5D-HCA2-GSK256073
21.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
21.05Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
21.05Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
21.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
21.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
21.05Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.05Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
21.05Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.05Consensushca_on_gpOrthosteric Ligandhca2_on_gp
21.05Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
21.05Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.83Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.83Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.83Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
20.69Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.69Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
20.69Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
20.69Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single7C4SS1P7C4S-S1P3-S1P
20.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
20.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
20.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
20.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
20.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
20.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
20.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
20.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
20.00Consensusdp_offOrthosteric Liganddp2_off
20.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
19.35Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
19.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.23Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
19.23Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.23Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5XR8AM8415XR8-CB1-AM841
19.05Single5XRAAM115425XRA-CB1-AM11542
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.05Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
19.05Single7FEECP559407FEE-CB1-CP55940-ZCZ011
19.05Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
19.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
19.05Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
19.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
19.05Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
19.05Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
19.05Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
19.05Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
19.05Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
19.05Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
19.05Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
18.75Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.52Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.52Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.52Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.52Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6KQICP559406KQI-CB1-CP55940-Org27569
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
18.18Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
18.18Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
18.18Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.18Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
18.18Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
17.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
17.86Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
17.86Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
17.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.86Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.65Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
17.65Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
17.65Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.65Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.65Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.65Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
17.65Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
17.65Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
17.65Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
17.39Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
17.39Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
17.39Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
17.39Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
17.39Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.39Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.39Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
17.39Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
17.39Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.67Single3PWHZM-2413853PWH-A2A-ZM-241385
16.67Single5EE7MK08935EE7-Glucagon-MK0893
16.67Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
16.67Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
16.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
16.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.67Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.67Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.13Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.13Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.13Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.00Single8WKYPG-9348WKY-MC4-PG-934
16.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
16.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
15.79Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.79Single8IHKAcifran8IHK-HCA3-Acifran
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.79Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
15.79Consensusgrh_offOrthosteric Ligandgnrh1_off
15.79Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.62Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.38Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
15.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
15.38Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.38Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
15.38Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
15.38Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
15.38Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.38Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
15.38Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.38Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.15Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.15Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
15.15Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
15.00Single6D27CAY104716D27-DP2-CAY10471
15.00Single6GPSMK08126GPS-CCR2-MK0812
15.00Single6IIVDaltroban6IIV-TP-Daltroban
15.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Single7V3ZCP559407V3Z-CB1-CP55940
15.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
15.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.00Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
14.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.81Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
14.81Single6W25SHU91196W25-MC4-SHU9119-Ca
14.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
14.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
14.81Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
14.81Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.81Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.29Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.29Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
14.29Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
14.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
14.29Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
14.29Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
14.29Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
14.29Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
13.79Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
13.79Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
13.79Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
13.79Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.79Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.64Single5TZRMK86665TZR-FFA1-MK8666
13.64Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
13.64Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
13.64Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.64Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
13.64Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.64Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
13.64Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.64Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.64Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.64Consensuslpa_onOrthosteric Ligandlpa1_on
13.64Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
13.64Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
13.64Consensusrelaxin_onOrthosteric Ligandrxfp4_on
13.64Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
13.51Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.51Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.33Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.16Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.04Single6IIURamatroban6IIU-TP-Ramatroban
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.04Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.04Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
13.04Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.04Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.90Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.90Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.82Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.50Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.50Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.50Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
12.50Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
12.50Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.50Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.50Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.50Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.50Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.12Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
12.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
12.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
12.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
12.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
12.00Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.76Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
11.76Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
11.76Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.76Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.54Single4XT1Fractalkine4XT1-US28-Fractalkine
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.54Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.54Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
11.54Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.54Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.43Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.11Single3OE9IT1t3OE9-CXCR4-IT1t
11.11Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.11Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.11Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.11Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
11.11Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single9B9Y7DY9B9Y-CB1-7DY
11.11Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.11Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.11Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.81Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.71Single3OE0CVX153OE0-CXCR4-CVX15
10.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
10.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.34Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.34Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.34Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.34Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
10.34Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.34Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
10.34Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.34Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
10.34Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.34Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
10.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.00Single8IYXYL-3658IYX-GPR34-YL-365
10.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
10.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
10.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
10.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
10.00Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Single4XT3Fractalkine4XT3-US28-Fractalkine
9.68Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
9.68Single6FJ3PTH6FJ3-PTH1-PTH
9.68Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
9.68Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.68Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
9.68Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.68Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
9.68Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.68Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
9.68Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
9.68Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.52Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
9.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
9.52Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
9.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.38Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.38Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
9.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.38Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.38Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.38Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.09Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.09Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.09Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.09Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.09Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.09Consensusep_offOrthosteric Ligandep4_off
9.09Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.70Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.70Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.70Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.70Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
8.70Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
8.70Single9BJKNAM9BJK-μ-Naloxone-NAM
8.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.11Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
8.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
8.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
8.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.69Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
7.69Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
7.69Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.41Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
7.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8KIGSHU91198KIG-MC3-SHU9119-Ca
7.41Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
7.14Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.14Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single7SK5CXCL127SK5-ACKR3-CXCL12
7.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.90Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.67Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.45Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.45Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.45Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.45Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.25Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.06Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.88Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
5.88Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.71Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
5.56Single3OE6IT1t3OE6-CXCR4-IT1t
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.56Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.56Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.26Single5L7IVismodegib5L7I-SMO-Vismodegib
5.26Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.26Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.26Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.26Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.26Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.26Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single3ODUIT1t3ODU-CXCR4-IT1t
5.00Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.00Single5U09Taranabant5U09-CB1-Taranabant
5.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
5.00Single9BA0A1AKN9BA0-CB1-A1AKN
5.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
4.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single8K2WAMG4878K2W-CXCR3-AMG487
4.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.76Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
4.76Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.55Single4QIMANTA XV4QIM-SMO-ANTA XV
4.55Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.55Single9B9ZA1AKO9B9Z-CB1-A1AKO
4.35Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.35Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.35Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.17Single5V56TC1145V56-SMO-TC114
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.17Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.17Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensusneurotensin_onOrthosteric Ligandnts1_on
4.17Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.00Single6OS2TRV0266OS2-AT1-TRV026
4.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8XQJJN2418XQJ-Apelin-JN241
4.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.85Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.85Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.85Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.70Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.70Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.70Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.57Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.57Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.33Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.33Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.03Single7SK3CXCL127SK3-ACKR3-CXCL12
2.94Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
2.94Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2

Consensus Members
Id Members
7E33 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2
8UGY 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
8UH3 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
Net Summary
Imin 2.95333
Number of Linked Nodes 862
Number of Links 1071
Number of Hubs 185
Number of Links mediated by Hubs 686
Number of Communities 23
Number of Nodes involved in Communities 269
Number of Links involved in Communities 403
Path Summary
Number Of Nodes in MetaPath 121
Number Of Links MetaPath 120
Number of Shortest Paths 1473579
Length Of Smallest Path 3
Average Path Length 32.931
Length of Longest Path 66
Minimum Path Strength 0.386667
Average Path Strength 5.99202
Maximum Path Strength 22.7983
Minimum Path Correlation 0.706667
Average Path Correlation 0.97492
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 36.3913
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.9782
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
5ht1_on_gp5ht1a_on_gp
5ht1d_on_gp
5ht1e_on_gp
5ht1f_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht1e_on_gp.zip



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