Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x46 6.295419
22x38 3.4409
32x42 6.37333658
42x46 6.1439
52x50 7.556539
62x57 5.13333619
72x59 7.235418
82x60 8.35418
9E1x50 7.94375819
103x28 9.5519
113x29 4.51419
123x32 10.3419
133x33 9.47519
143x37 6.994519
153x45 3.9375458
163x51 9.4575469
17I2x56 10.2075478
184x50 4.794519
194x53 2.9875419
204x57 9.105418
21E2.F168 6.4225406
22E2.Q171 9.0675422
23E2.V174 7.34422
24E2x50 6.315419
25E2x51 5.56427
26E2.F184 5.7225419
275x39 4.192509
285x461 7.7475419
295x47 11.398519
305x54 5.87409
315x57 7.8425407
325x58 5.9475409
335x62 3.025408
346x29 8.885408
356x44 6.1375419
366x48 7.45167619
376x51 8.472519
386x52 9.53667619
397x38 6.348518
407x39 4.99719
417x42 6.95375819
427x53 5.554539
438x50 5.055409
448x54 4.465409
45Lig 10.625810
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
11x43 2x57 11.39524.86NoYes099
22x57 7x42 42.05713.59YesYes199
32x53 7x42 51.72053.79NoYes199
42x53 7x46 52.56028.08NoNo099
52x50 7x46 52.320310.31YesNo099
61x50 2x50 75.16316.73NoYes099
71x47 2x54 18.34471.84NoNo069
81x47 1x51 13.84662.98NoNo068
91x50 2x47 67.90612.98NoNo099
101x53 2x47 66.01696.46NoNo099
111x53 7x54 64.11283.53NoNo099
127x54 8x50 60.52182.89NoYes099
138x50 8x54 26.94365.36YesYes099
147x42 Lig 84.5944.25YesYes190
153x37 Lig 45.97055.34YesYes190
163x37 4x53 56.15113.2YesYes199
174x50 4x53 35.83483.71YesYes199
182x52 4x50 15.91572.35NoYes089
192x48 2x52 10.5933.07NoNo068
208x53 8x54 15.99825.19NoYes089
211x56 8x53 13.75671.68NoNo098
221x56 8x57 11.50011.62NoNo098
238x50 I1x50 30.02477.31YesNo099
242x40 I1x50 28.16555.49NoNo099
252x37 2x40 26.17897.31NoNo099
262x37 2x38 24.01233.17NoYes099
272x38 I2x57 15.1815.23YesNo099
282x46 2x50 37.7395.43YesYes399
292x46 7x53 37.30413.52YesYes399
303x46 7x53 27.20598.21NoYes099
312x42 3x46 25.75165.86YesNo089
322x45 4x50 27.35594.94NoYes099
332x45 4x46 21.57589.29NoNo099
342x42 4x46 21.05854.84YesNo089
352x46 3x43 14.68634.47YesNo399
362x50 7x49 13.35189.42YesNo399
371x51 2x51 11.57512.77NoNo088
382x60 3x28 35.744811.3YesYes189
392x60 7x42 25.624111.63YesYes189
403x33 Lig 68.355919.12YesYes190
413x33 E2.F184 84.67656.19YesYes199
42E2.F168 E2.F184 93.50037.5YesYes069
43E2.F168 E2.Q170 74.68332.34YesNo065
44E2.Q170 E2.Q171 71.98445.12NoYes052
45E2.Q171 E2.V174 34.695310.03YesYes222
46E2.V174 E2x51 26.08148.56YesYes227
473x22 E2x51 46.46532.33NoYes057
48E2.Q171 E2.Y185 28.84026.76YesNo227
49E2.Y185 E2x51 26.15647.86NoYes277
503x22 E2.D183 35.2053.57NoNo057
513x28 3x29 10.36065.69YesYes199
523x34 4x53 24.58211.62NoYes099
533x30 3x34 10.00821.62NoNo099
543x29 E2x52 14.34894.42YesNo099
55E2.F184 E2x52 16.03575.19YesNo099
563x36 Lig 11.91246.8NoYes190
573x33 4x57 17.977415.43YesYes198
583x37 4x57 29.73999.7YesYes198
596x51 7x38 20.79624.84YesYes198
603x36 6x48 16.06574.94NoYes199
616x52 Lig 80.74828.83YesYes190
626x48 6x52 31.20174.01YesYes199
635x47 6x52 10023.58YesYes199
645x47 6x44 83.70944.29YesYes199
655x54 6x44 86.05598.71YesYes099
663x44 5x54 15.06113.73NoYes089
673x46 3x50 15.3916.07NoNo099
683x47 5x54 73.96366.48NoYes089
693x47 5x57 34.1784.19NoYes087
703x47 5x58 45.363214.79NoYes089
713x51 5x57 25.83412.38YesYes097
723x51 3x55 11.597614.65YesNo698
73I2x52 I2x57 13.21693.2NoNo059
742x42 4x42 13.48682.67YesNo089
752x41 4x42 10.81791.58NoNo089
763x34 4x54 12.47471.31NoNo095
774x51 4x54 10.00823.22NoNo055
784x57 5x43 32.35627.28YesNo088
795x39 5x43 28.07567.78YesNo098
804x60 5x39 14.34144.33NoYes099
815x39 E2.F168 16.39555.36YesYes096
82E2.D183 E2.W165 29.381.12NoNo079
83E2.N166 E2.W165 17.676.78NoNo069
846x52 6x55 54.74178.57YesNo098
855x40 6x55 51.810517.37NoNo098
865x40 6x58 33.90064.36NoNo096
876x58 7x30 25.06187.08NoNo066
885x40 6x59 15.77331.61NoNo098
895x47 5x48 28.472914.44YesNo098
905x48 6x53 20.12894.84NoNo087
915x58 6x37 42.3273.52YesNo099
925x62 6x37 39.30582.34YesNo089
935x62 5x66 30.89443.09YesNo087
945x66 6x30 24.6873.49NoNo878
956x29 6x30 22.003111.63YesNo088
966x25 6x29 12.67713.64NoYes058
976x40 7x53 12.31734.84NoYes099
987x52 7x53 12.64713.63NoYes099
996x49 6x53 17.35512.94NoNo087
1006x48 7x45 42.69449.04YesNo099
1016x47 7x45 14.61139.45NoNo099
1027x30 E3.C444 12.64711.57NoNo065
1035x39 5x42 14.94112.49YesNo097
1047x39 7x42 12.27983.86YesYes199
1052x54 2x57 20.30146.99NoYes199
1063x28 E1x50 20.72878.43YesYes199
1073x33 6x51 37.78392.98YesYes199
1086x51 6x52 51.05336.19YesYes199
1097x45 7x49 30.549512.26NoNo099
1105x461 6x52 18.97446.04YesYes199
1113x43 5x54 27.94814.56NoYes099
1123x50 5x58 15.2263.09NoYes099
1133x43 7x53 12.70717.57NoYes399
1142x46 7x49 16.485510.98YesNo399
1153x37 5x461 17.490110.24YesYes199
1164x57 E2.F184 10.35314.01YesYes189
1172x60 7x38 11.11037.08YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x532x563.211NoNo9922
2x537x423.791NoYes9921
2x563x3213.151NoYes9921
2x567x425.051NoYes9921
2x577x394.651YesYes9922
2x577x423.591YesYes9921
2x607x387.081YesYes8822
2x607x393.391YesYes8922
2x607x4211.631YesYes8921
3x323x364.421YesNo9911
3x327x4213.791YesYes9911
3x32Lig9.841YesYes9010
3x334x5715.431YesYes9812
3x334x613.631YesNo9912
3x33E2.F1846.191YesYes9912
3x336x512.981YesYes9911
3x33Lig19.121YesYes9010
3x366x484.941NoYes9912
3x36Lig6.81NoYes9010
3x373x416.491YesNo9812
3x374x533.21YesYes9912
3x374x579.71YesYes9812
3x375x46110.241YesYes9911
3x37Lig5.341YesYes9010
3x415x4617.251NoYes8921
4x57E2.F1844.011YesYes8922
5x4616x526.041YesYes9911
5x461Lig7.461YesYes9010
5x476x483.011YesYes9922
5x476x5223.581YesYes9921
6x486x524.011YesYes9921
6x516x526.191YesYes9911
6x517x374.991YesNo9912
6x517x384.841YesYes9812
6x51Lig23.361YesYes9010
6x526x558.571YesNo9812
6x52Lig8.831YesYes9010
7x387x393.521YesYes8922
7x387x429.671YesYes8921
7x397x423.861YesYes9921
7x42Lig4.251YesYes9010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
100.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
77.78Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
72.73Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
72.73Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
72.73Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
72.73Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
70.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
70.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
70.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
70.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
70.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
66.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
66.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
66.67Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single3RZECidoxepin3RZE-H1-Cidoxepin
63.64Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
63.64Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
63.64Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
63.64Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
63.64Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
63.64Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
63.64Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
63.64Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
63.64Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
63.64Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
63.64Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
63.64Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGIEpinephrine8GGI-β2-Epinephrine
63.64Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
63.64Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
63.64Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
63.64Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
63.64Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
63.64Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
63.64Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
63.64Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
61.54Single4U15Tiotropium4U15-M3-Tiotropium
61.54Single6OL9Tiotropium6OL9-M5-Tiotropium
61.54Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
61.54Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
61.54Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
61.54Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
60.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
60.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
60.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
60.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
60.00Single7SRQLSD7SRQ-5-HT2B-LSD
60.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
60.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
60.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
60.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
58.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
58.33Single4MQSIperoxo4MQS-M2-Iperoxo
58.33Single4U14Tiotropium4U14-M3-Tiotropium
58.33Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
58.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
58.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
58.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
58.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
58.33Single6H7MSalbutamol6H7M-β1-Salbutamol
58.33Single6PS1Timolol6PS1-β2-Timolol
58.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
58.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
58.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
58.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
58.33Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
58.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
58.33Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
58.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
58.33Single8GGNEpinephrine8GGN-β2-Epinephrine
58.33Single8GGOEpinephrine8GGO-β2-Epinephrine
58.33Single8GGUEpinephrine8GGU-β2-Epinephrine
58.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
58.33Single8JJOAlprenolol8JJO-β2-Alprenolol
58.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
58.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
58.33Single8X64Desloratadine8X64-H1-Desloratadine
58.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
58.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
58.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
58.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
58.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
58.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
58.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
58.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Consensushistamine_onOrthosteric Ligandh1_on h4_on
58.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
58.33Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
58.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
58.33Consensustar_onOrthosteric Ligandta1_on
57.14Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
57.14Single5CXVTiotropium5CXV-M1-Tiotropium
57.14Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
57.14Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
57.14Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
57.14Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
55.56Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
55.56Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
54.55Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
54.55Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
54.55Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
54.55Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
54.55Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
54.55Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
54.55Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGVEpinephrine8GGV-β2-Epinephrine
54.55Single8GGWEpinephrine8GGW-β2-Epinephrine
54.55Single8GGXEpinephrine8GGX-β2-Epinephrine
54.55Single8GH0Epinephrine8GH0-β2-Epinephrine
54.55Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
54.55Consensusalpha1_onOrthosteric Ligandalpha1a_on
54.55Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
53.85Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
53.85Single2Y03Isoprenaline2Y03-β1-Isoprenaline
53.85Single5WIUNemonapride5WIU-D4-Nemonapride
53.85Single5WIVNemonapride5WIV-D4-Nemonapride-Na
53.85Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
53.85Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
53.85Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
53.85Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
53.85Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
53.85Single7WC6LSD7WC6-5-HT2A-LSD
53.85Single7XKAEpinephrine7XKA-β2-Epinephrine
53.85Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
53.85Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
53.85Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
53.85Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
53.85Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
53.85Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
53.85Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
53.85Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
53.85Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
53.85Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
53.85Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
53.85Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
53.85Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
53.85Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
53.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
50.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
50.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
50.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
50.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
50.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
50.00Single6A94Zotepine6A94-5-HT2A-Zotepine
50.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
50.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
50.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
50.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
50.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
50.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
50.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
50.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
50.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
50.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
50.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
50.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
50.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGKEpinephrine8GGK-β2-Epinephrine
50.00Single8GGLEpinephrine8GGL-β2-Epinephrine
50.00Single8GGMEpinephrine8GGM-β2-Epinephrine
50.00Single8GGPEpinephrine8GGP-β2-Epinephrine
50.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
50.00Single8GGTEpinephrine8GGT-β2-Epinephrine
50.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
50.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
50.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
50.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
50.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
50.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
50.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
50.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
50.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
50.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
50.00Consensussensory_offOrthosteric Ligandopsin_off
47.06Single4IARErgotamine4IAR-5-HT1B-Ergotamine
46.67Single4AMIBucindolol4AMI-β1-Bucindolol
46.67Single4LDEBI1671074LDE-β2-BI167107
46.67Single6CM4Risperidone6CM4-D2-Risperidone
46.67Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
46.67Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
46.67Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
46.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
46.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
46.67Single8JJ8Formoterol8JJ8-β2-Formoterol
46.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
46.67Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
46.67Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
46.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
46.15Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
46.15Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
46.15Single2Y04Salbutamol2Y04-β1-Salbutamol
46.15Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
46.15Single3NY8ICI 118-5513NY8-β2-ICI 118-551
46.15Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
46.15Single4DAJTiotropium4DAJ-M3-Tiotropium
46.15Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
46.15Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
46.15Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
46.15Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
46.15Single5DSGTiotropium5DSG-M4-Tiotropium
46.15Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
46.15Single6DRXLisuride6DRX-5-HT2B-Lisuride
46.15Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
46.15Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
46.15Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
46.15Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
46.15Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
46.15Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
46.15Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
46.15Single7WC7Lisuride7WC7-5-HT2A-Lisuride
46.15Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
46.15Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.15Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
46.15Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.15Single8X63Mepyramine8X63-H1-Mepyramine
46.15Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
46.15Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
46.15Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.15Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
46.15Consensustachykinin_offOrthosteric Ligandnk1_off
45.45Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
45.45Single3PBLEticlopride3PBL-D3-Eticlopride
45.45Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
45.45Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
45.45Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
45.45Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
45.45Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
45.45Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
45.45Single8GGSEpinephrine8GGS-β2-Epinephrine
45.45Single8GGYEpinephrine8GGY-β2-Epinephrine
45.45Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
45.45Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
45.45Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
43.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
43.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
43.75Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
43.75Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Single6H7LDobutamine6H7L-β1-Dobutamine
43.75Single6IBLArformoterol6IBL-β1-Arformoterol
43.75Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
43.75Single7UM4AS26747237UM4-5-HT5A-AS2674723
43.75Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
43.75Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
43.75Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
42.86Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
42.86Single5C1MBU725C1M-μ-BU72
42.86Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
42.86Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
42.86Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
42.86Single6E67BI1671076E67-β2-BI167107-Gs (fused)
42.86Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
42.86Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
42.86Single6PS6Timolol6PS6-β2-Timolol
42.86Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
42.86Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
42.86Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
42.86Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
42.86Single8EA0Iperoxo8EA0-M3-Iperoxo
42.86Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
42.86Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
42.86Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
42.86Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
42.86Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
42.86Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
42.86Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
41.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
41.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
41.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
41.67Single5DHHSB-6121115DHH-NOP-SB-612111
41.67Single6KUXRS-799486KUX-α2a-RS-79948
41.67Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
41.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
41.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
41.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
41.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
41.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.67Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
41.67Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
41.67Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
41.67Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8IWESpermidine8IWE-TAAR9-Spermidine
41.67Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.67Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.67Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
41.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.67Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
41.67Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
41.67Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
41.67Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
41.67Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
41.67Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single3NY9PubChem 9131033NY9-β2-PubChem 913103
41.18Single7SK9CCX6627SK9-ACKR3-CCX662
41.18Single8X5YAstemizole8X5Y-H1-Astemizole
40.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
40.00Single2YDVNECA2YDV-A2A-NECA
40.00Single3P0GBI1671073P0G-β2-BI167107
40.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
40.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
40.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.00Single4UHRCGS216804UHR-A2A-CGS21680
40.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
40.00Single5G53NECA5G53-A2A-NECA-Gs
40.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
40.00Single6E59L-7607356E59-NK1-L-760735
40.00Single6J20Aprepitant6J20-NK1-Aprepitant
40.00Single6J21Aprepitant6J21-NK1-Aprepitant
40.00Single6WGTLSD6WGT-5-HT2A-LSD
40.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
40.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
40.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
40.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
40.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
40.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
40.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
40.00Single8E0GBU728E0G-μ-BU72
40.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
40.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
40.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
40.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
40.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
40.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
40.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
40.00Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
40.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
40.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
40.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
38.89Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
38.89Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
38.46Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
38.46Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
38.46Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.46Single6IQLL7458706IQL-D4-L745870
38.46Single6TPGEMPA6TPG-OX2-EMPA
38.46Single6TPNHTL66416TPN-OX2-HTL6641
38.46Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
38.46Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
38.46Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
38.46Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
38.46Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
38.46Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
38.46Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
37.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
37.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
37.50Single6A93Risperidone6A93-5-HT2A-Risperidone
37.50Single6HLPNetupitant6HLP-NK1-Netupitant
37.50Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
37.50Single6MXTSalmeterol6MXT-β2-Salmeterol
37.50Single7DFPSpiperone7DFP-D2-Spiperone
37.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
37.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
37.50Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
37.50Single7YITNalfurafine7YIT-κ-Nalfurafine
37.50Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
37.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
37.50Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
36.84Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
36.36Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
36.36Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
36.36Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
36.36Single8GGREpinephrine8GGR-β2-Epinephrine
36.36Single8GGZEpinephrine8GGZ-β2-Epinephrine
36.36Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
36.36Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.71Single2Y01Dobutamine2Y01-β1-Dobutamine
35.71Single2Y02Carmoterol2Y02-β1-Carmoterol
35.71Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.71Single4EJ4Naltrindole4EJ4-δ-Naltrindole
35.71Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.71Single7BU7BI1671077BU7-β1-BI167107
35.71Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
35.71Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
35.71Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
35.71Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
35.71Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.71Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
35.71Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
35.71Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
35.71Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
35.29Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.29Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
35.29Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
35.29Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
35.29Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
35.29Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
35.29Consensusendothelin_offOrthosteric Ligandetb_off
35.29Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
35.00Single5WF5UK-4320975WF5-A2A-UK-432097
33.33Single2Y00Dobutamine2Y00-β1-Dobutamine
33.33Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
33.33Single4UG2CGS216804UG2-A2A-CGS21680
33.33Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single5TVNLSD5TVN-5-HT2B-LSD
33.33Single5WQCEMPA5WQC-OX2-EMPA
33.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
33.33Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
33.33Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
33.33Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
33.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
31.82Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
31.58Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
31.58Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
31.58Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
31.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
31.25Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
31.25Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
31.25Single5X93K-87945X93-ETB-K-8794
31.25Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
31.25Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
31.25Single7B6WCyclazosin7B6W-α1b-Cyclazosin
31.25Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
31.25Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
31.25Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.25Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
31.25Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
31.25Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
31.25Consensusa2_onOrthosteric Liganda2a_on a2b_on
31.25Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
31.25Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
31.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.25Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
30.77Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
30.77Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
30.77Single6AKXA4R6AKX-CCR5-A4R
30.77Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.77Single6B73PubChem 1319551386B73-κ-PubChem 131955138
30.77Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
30.77Single6ME2Ramelteon6ME2-MT1-Ramelteon
30.77Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Single6TODEMPA6TOD-OX1-EMPA-Na
30.77Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
30.77Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
30.77Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
30.77Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
30.77Consensusgt_class-aOrthosteric Ligandgt_opsin
30.77Consensusgt_opsinOrthosteric Ligandgt_sensory
30.77Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
30.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
30.00Single3QAKUK-4320973QAK-A2A-UK-432097
30.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
30.00Single6HLOAprepitant6HLO-NK1-Aprepitant
30.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
30.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
29.41Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.41Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.41Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
29.41Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.41Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
29.41Single8JJLOlodaterol8JJL-β2-Olodaterol
29.41Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
29.41Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.41Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
29.17Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
28.57Single2YDOAdenosine2YDO-A2A-Adenosine
28.57Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
28.57Single4MBSMaraviroc4MBS-CCR5-Maraviroc
28.57Single4ZJCSB-6740424ZJC-OX1-SB-674042
28.57Single6DS0Ly2660976DS0-5-HT2B-Ly266097
28.57Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
28.57Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
28.57Single6PT2KGCHM076PT2-δ-KGCHM07
28.57Single6VI4JDTic6VI4-κ-JDTic
28.57Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
28.57Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
28.57Single7VODCariprazine7VOD-5-HT2A-Cariprazine
28.57Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
28.57Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
28.57Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
28.57Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
28.57Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
28.57Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
28.57Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
28.57Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
27.78Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
27.78Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.78Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
27.78Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
27.78Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
27.78Single7EZCUKA7EZC-A2A-UKA
27.78Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
27.78Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
27.78Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
27.78Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.27Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
27.27Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
27.27Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
27.27Consensussensory_onOrthosteric Ligandopsin_on
26.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
26.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
26.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.67Single6TOTLemborexant6TOT-OX1-Lemborexant
26.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
26.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.67Single7UL4Alvimopan7UL4-μ-Alvimopan
26.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
26.67Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
26.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.67Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
26.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
26.67Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
26.67Consensusadenosine_onOrthosteric Liganda1_on a2_on
26.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Consensusblt_onOrthosteric Ligandblt1_on
26.67Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
26.67Consensusgi_hcarOrthosteric Ligandgi_hca
26.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
26.67Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.67Consensusleuko_onOrthosteric Ligandblt_on
26.67Consensusnucleotide_onOrthosteric Ligandadenosine_on
26.32Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
25.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
25.00Single3UZAGTPL92363UZA-A2A-GTPL9236
25.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5XPRBosentan5XPR-ETB-Bosentan
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
25.00Single6TP6Filorexant6TP6-OX1-Filorexant
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
25.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
25.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
25.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
25.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
25.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
23.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.81Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
23.81Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
23.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.53Single4DJHJDTic4DJH-κ-JDTic
23.53Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
23.53Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.53Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
23.53Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
23.53Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
23.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
23.53Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
23.53Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
23.53Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
23.08Single6HLLCP999946HLL-NK1-CP99994
23.08Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
23.08Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
23.08Single6TP4ACT-4622066TP4-OX1-ACT-462206
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.08Single8GH1Epinephrine8GH1-β2-Epinephrine
23.08Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
23.08Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
23.08Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
23.08Single8K5BNiacin8K5B-HCA2-Niacin
23.08Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.08Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
23.08Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
22.73Consensusangiotensin_onOrthosteric Ligandat1_on
22.73Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
22.73Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
22.73Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
22.22Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
22.22Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.22Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
22.22Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
22.22Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
22.22Single8JWZAB9288JWZ-A2A-AB928-Na
22.22Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8WU1KCA8WU1-CB1-KCA-Arrestin1
22.22Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
22.22Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Consensusgs_steroidOrthosteric Ligandgs_bileacid
22.22Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
22.22Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
22.22Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
21.74Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.74Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
21.74Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.74Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
21.43Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
21.43Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.43Single5WS3EMPA5WS3-OX2-EMPA
21.43Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.43Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.43Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
21.43Single7F8ULintitript7F8U-CCKA-Lintitript
21.43Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.43Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.43Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.43Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
21.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.43Single8IHKAcifran8IHK-HCA3-Acifran
21.43Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.43Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.43Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.43Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.05Single5CGDHTL142425CGD-mGlu5-HTL14242
21.05Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
21.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
21.05Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
21.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
21.05Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
21.05Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Consensusorexin_onOrthosteric Ligandox2_on
21.05Consensussteroid_onOrthosteric Ligandbileacid_on
20.83Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.83Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single5ZTYAM102575ZTY-CB2-AM10257
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6V9SGTPL114036V9S-OX1-GTPL11403
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7XN9L-054,5227XN9-SST2-L-054,522
20.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
20.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
20.00Single8K5CAcipimox8K5C-HCA2-Acipimox
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
20.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
20.00Consensushcar_onOrthosteric Ligandhca_on
20.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
20.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
20.00Consensuss1p_offOrthosteric Ligands1p1_off
20.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
19.23Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
19.05Single7F8XNN90567F8X-CCKA-NN9056
19.05Single7QA8Peptide7QA8-STE2-Peptide
19.05Single7QA8Peptide7QA8-STE2-Peptide
19.05Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
19.05Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.05Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.05Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
19.05Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
19.05Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
19.05Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
19.05Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
18.75Single4YAYZD-71554YAY-AT1-ZD-7155
18.75Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
18.75Single5TGZAM65385TGZ-CB1-AM6538
18.75Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
18.75Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.75Single6FFHFenobam6FFH-mGlu5-Fenobam
18.75Single6GPSMK08126GPS-CCR2-MK0812
18.75Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
18.75Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
18.75Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
18.75Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
18.75Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.75Single8CU6LJ-45178CU6-A2A-LJ-4517
18.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
18.75Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
18.75Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
18.75Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
18.75Single8K5DGSK2560738K5D-HCA2-GSK256073
18.75Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
18.75Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
18.75Consensuscck_offOrthosteric Ligandccka_off
18.75Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.75Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
18.75Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
18.18Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.18Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
18.18Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.18Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
18.18Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.86Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
17.65Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.65Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
17.65Single5NM2ZM2413855NM2-A2A-ZM241385-Na
17.65Single6D26Fevipiprant6D26-DP2-Fevipiprant
17.65Single6GPXMK08126GPX-CCR2-MK0812
17.65Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.65Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
17.65Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
17.65Single7C4SS1P7C4S-S1P3-S1P
17.65Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
17.65Single7SINNPS-21437SIN-CaS-NPS-2143
17.65Single7SINNPS-21437SIN-CaS-NPS-2143
17.65Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
17.65Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
17.65Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.65Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
17.65Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
17.65Single8QOTNanobody E8QOT-μ-Nanobody E
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
17.65Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.65Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
17.39Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.39Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
17.39Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
17.39Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
17.39Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
17.39Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.39Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
16.67Single5TZR-5TZR-FFA1 (GPR40)-MK8666
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
16.67Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.67Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7EPENAM5637EPE-mGlu-NAM563
16.67Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7W41PD1762527W41-BB2-PD176252
16.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
16.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
16.67Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
16.67Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
16.67Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
16.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
16.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Consensusadenosine_offOrthosteric Liganda1_off a2_off
16.67Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
16.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
16.67Consensusbombesin_offOrthosteric Ligandbb2_off
16.67Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
16.67Consensusclass-d_onOrthosteric Ligandste2_on
16.67Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
16.67Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
16.67Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single4N4WSANT-14N4W-SMO-SANT-1
15.79Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.79Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.79Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
15.79Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7K15MKD0467K15-BLT1-MKD046-Na
15.79Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
15.79Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.79Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.79Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
15.79Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
15.79Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
15.79Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
15.79Consensusblt_offOrthosteric Ligandblt1_off
15.79Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
15.79Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
15.79Consensusdp_offOrthosteric Liganddp2_off
15.79Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.79Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
15.79Consensusgi_class-fOther Ligandgi_frizzled
15.79Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
15.79Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.79Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.79Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
15.79Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
15.38Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
15.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
15.38Single6ME5Agomelatine6ME5-MT1-Agomelatine
15.38Single6ME9Ramelteon6ME9-MT2-Ramelteon
15.38Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
15.38Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
15.38Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
15.38Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
15.38Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
15.38Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
15.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
15.00Single6K1QIRL25006K1Q-ETB-IRL2500
15.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
15.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
15.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
15.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
15.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
15.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
15.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
15.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
15.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
14.81Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.81Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single5EE7MK08935EE7-Glucagon-MK0893
14.29Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
14.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6IGLIRL16206IGL-ETB-IRL1620
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
14.29Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
14.29Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
14.29Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
14.29Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
14.29Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
14.29Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
14.29Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
14.29Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
14.29Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
14.29Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
14.29Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
14.29Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
14.29Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
14.29Consensusclass-d_offOrthosteric Ligandste2_off
14.29Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
14.29Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
14.29Consensusgo_class-b2Orthosteric Ligandgo_adhesion
14.29Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.29Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
14.29Consensuslpl_offOrthosteric Ligands1p_off lpa_off
14.29Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
14.29Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.64Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.64Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
13.64Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.64Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
13.64Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.64Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.64Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.33Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
13.33Single5K2DZM2413855K2D-A2A-ZM241385
13.33Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
13.33Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.33Single6JZHZM2413856JZH-A2A-ZM241385-Na
13.33Single6PS7ZM2413856PS7-A2A-ZM241385-Na
13.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
13.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
13.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.33Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
13.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
13.33Single7XRRLemborexant7XRR-OX2-Lemborexant
13.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.33Single8GNGIstradefylline8GNG-A2A-Istradefylline
13.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
13.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
13.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
13.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
13.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
13.33Consensusmglu_onOther Ligandmglu2_on mglu4_on
13.04Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
13.04Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
13.04Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
13.04Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
13.04Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
12.50Single3REYPubChem 56973REY-A2A-PubChem 5697
12.50Single5IU4ZM2413855IU4-A2A-ZM241385-Na
12.50Single5IU7Q274563465IU7-A2A-Q27456346-Na
12.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
12.50Single5JTBZM2413855JTB-A2A-ZM241385
12.50Single5K2BZM2413855K2B-A2A-ZM241385-Na
12.50Single5K2CZM2413855K2C-A2A-ZM241385-Na
12.50Single5NLXZM2413855NLX-A2A-ZM241385-Na
12.50Single5NM4ZM2413855NM4-A2A-ZM241385-Na
12.50Single5UVIZM2413855UVI-A2A-ZM241385
12.50Single6AQFZM2413856AQF-A2A-ZM241385
12.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.50Single6W25SHU91196W25-MC4-SHU9119-Ca
12.50Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
12.50Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
12.50Single7AROLUF58337ARO-A2A-LUF5833-Na
12.50Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
12.50Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
12.50Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
12.50Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.50Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
12.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
12.50Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IYXYL-3658IYX-GPR34-YL-365
12.50Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
12.50Consensusclass-c_offOther Ligandgabab_off mglu_off
12.50Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
12.50Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.50Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.50Consensusgnrh_offOrthosteric Ligandgnrh1_off
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
12.50Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
12.50Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
12.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
12.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.76Single3EMLZM2413853EML-A2A-ZM241385
11.76Single4EIYZM2413854EIY-A2A-ZM241385-Na
11.76Single5IU8Q274563475IU8-A2A-Q27456347-Na
11.76Single5K2AZM2413855K2A-A2A-ZM241385-Na
11.76Single5OLGZM2413855OLG-A2A-ZM241385-Na
11.76Single5UENDU1725UEN-A1-DU172
11.76Single5VRAZM2413855VRA-A2A-ZM241385-Na
11.76Single6D27CAY104716D27-DP2-CAY10471
11.76Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.76Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.76Single6IIVDaltroban6IIV-TP-Daltroban
11.76Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
11.76Single6LPJZM2413856LPJ-A2A-ZM241385-Na
11.76Single6LPKZM2413856LPK-A2A-ZM241385-Na
11.76Single6S0LZM2413856S0L-A2A-ZM241385
11.76Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.76Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.76Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.76Single7PYRPSB-21157PYR-A2A-PSB-2115
11.76Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
11.76Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.76Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.76Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
11.76Consensusa2_offOrthosteric Liganda2a_off
11.76Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
11.76Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
11.76Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.76Consensushcar_offOrthosteric Ligandsuccinate_off
11.76Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.76Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.76Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
11.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.76Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
11.54Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
11.54Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
11.54Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
11.54Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
11.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.54Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.54Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.54Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
11.54Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
11.54Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.54Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
11.54Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.54Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.11Single5IUAQ274563485IUA-A2A-Q27456348-Na
11.11Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
11.11Single5N2SPSB365N2S-A1-PSB36
11.11Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
11.11Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.11Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.11Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.11Single6LPLZM2413856LPL-A2A-ZM241385-Na
11.11Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
11.11Single6S0QZM2413856S0Q-A2A-ZM241385
11.11Single6WQAZM2413856WQA-A2A-ZM241385-Na
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
11.11Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7RM5ZM2413857RM5-A2A-ZM241385-Na
11.11Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single7YXAONO-54306087YXA-S1P5-ONO-5430608
11.11Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single8FYNZM2413858FYN-A2A-ZM241385-Na
11.11Single8GNEKW-63568GNE-A2A-KW-6356-Na
11.11Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
11.11Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.11Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
11.11Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.11Consensusep_offOrthosteric Ligandep4_off
11.11Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
11.11Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
11.11Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.71Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.71Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.71Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
10.71Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
10.71Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.71Consensusgo_class-b1Orthosteric Ligandgo_crf
10.71Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.71Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single5XRAAM115425XRA-CB1-AM11542
10.53Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.53Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
10.53Single7P2L4YI7P2L-mGlu5-4YI
10.53Single7PX4PSB-21137PX4-A2A-PSB-2113
10.53Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
10.53Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
10.53Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
10.53Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
10.53Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensuscck_onOrthosteric Ligandccka_on cckb_on
10.53Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.53Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.53Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
10.53Consensuslpa_offOrthosteric Ligandlpa1_off
10.53Consensuslpa_onOrthosteric Ligandlpa1_on
10.53Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.53Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.34Single6LMLGlucagon6LML-Glucagon-Glucagon
10.34Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.34Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.34Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
10.34Single8IY6Endothelin-18IY6-ETB-Endothelin-1
10.34Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
10.34Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
10.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
10.00Single5X33BIIL2605X33-BLT1-BIIL260
10.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
10.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
10.00Single6IIURamatroban6IIU-TP-Ramatroban
10.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
10.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
10.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
10.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
10.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
10.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
10.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
10.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
10.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
10.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
10.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
10.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.68Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
9.68Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.68Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.68Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
9.68Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.68Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
9.52Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.52Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.52Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.52Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.52Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
9.52Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.52Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
9.52Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
9.52Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
9.52Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
9.52Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.52Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.52Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
9.52Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.38Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
9.38Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.38Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
9.38Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
9.09Single5MZPCaffeine5MZP-A2A-Caffeine-Na
9.09Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
9.09Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
9.09Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
9.09Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
9.09Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
9.09Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
9.09Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
9.09Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
9.09Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
9.09Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
9.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
9.09Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
9.09Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
9.09Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
9.09Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.82Consensuspth_onOrthosteric Ligandpth1_on pth2_on
8.70Single4XT1Fractalkine4XT1-US28-Fractalkine
8.70Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
8.70Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.70Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
8.70Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.70Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
8.70Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
8.70Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
8.33Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
8.33Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
8.33Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.33Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
8.33Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.33Single7SHEPI; PE7SHE-GPR158-PI; PE
8.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
8.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
8.33Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8PWNTheophylline8PWN-A2A-Theophylline
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusclass-c_onOther Ligandgabab_on mglu_on
8.33Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
8.33Consensussst_offOrthosteric Ligandsst2_off
8.33Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
8.11Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
8.00Single3OE0CVX153OE0-CXCR4-CVX15
8.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
8.00Single7XNACYN1548067XNA-SST2-CYN154806
8.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
8.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
8.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.69Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.69Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
7.69Single8A2OTheophylline8A2O-A2A-Theophylline-Na
7.69Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
7.69Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.69Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
7.69Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
7.69Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
7.69Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
7.69Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
7.41Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.41Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
7.41Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
7.41Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
7.41Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
7.41Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.41Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single3OE6IT1t3OE6-CXCR4-IT1t
7.14Single3OE8IT1t3OE8-CXCR4-IT1t
7.14Single4XT3Fractalkine4XT3-US28-Fractalkine
7.14Single6FJ3PTH6FJ3-PTH1-PTH
7.14Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.14Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
7.14Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
7.14Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
7.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
7.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
7.14Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
7.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
7.14Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
7.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.14Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
7.14Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.90Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
6.90Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.90Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.90Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
6.67Single3OE9IT1t3OE9-CXCR4-IT1t
6.67Single5L7IVismodegib5L7I-SMO-Vismodegib
6.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.67Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
6.67Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.67Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.67Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
6.67Consensusclass-t_onOrthosteric Ligandtaste2_on
6.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.67Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.67Consensusgs_class-tOrthosteric Ligandgs_taste
6.67Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
6.67Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.45Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.45Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.25Single3ODUIT1t3ODU-CXCR4-IT1t
6.25Single3PWHZM2413853PWH-A2A-ZM241385
6.25Single5U09Taranabant5U09-CB1-Taranabant
6.25Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.25Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
6.25Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.25Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
6.25Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
6.25Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
6.25Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
6.25Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
6.25Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
6.06Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
6.06Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
5.88Single6MH8ZM2413856MH8-A2A-ZM241385
5.88Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.88Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.88Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.88Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
5.88Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.88Single8K2WAMG4878K2W-CXCR3-AMG487
5.88Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.88Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.88Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.71Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.71Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
5.56Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
5.56Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
5.56Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
5.56Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
5.41Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
5.26Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
5.26Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.26Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.26Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.26Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.26Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.26Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.13Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
5.00Single6OS1TRV0266OS1-AT1-TRV026
5.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
5.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
5.00Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
5.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.00Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
5.00Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
5.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
5.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
5.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
5.00Consensuschemerin_onOrthosteric Ligandcml1_on
5.00Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
5.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.76Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.76Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.76Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.76Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
4.76Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
4.76Single7SHEPI; PE7SHE-GPR158-PI; PE
4.76Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.76Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.76Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.76Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
4.76Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
4.55Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.55Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.55Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
4.55Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
4.55Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.35Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
4.35Single6KNMJN241-96KNM-Apelin-JN241-9
4.35Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
4.35Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.35Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Consensusgs_class-b2Orthosteric Ligandgs_adgr
4.35Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
4.17Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
4.17Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
4.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single7SK5CXCL127SK5-ACKR3-CXCL12
4.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.85Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.85Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
3.85Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
3.85Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.70Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
3.70Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
3.57Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.57Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
3.45Single7SK3CXCL127SK3-ACKR3-CXCL12
3.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.45Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
3.45Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.33Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.33Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.23Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.12Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.12Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.03Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.86Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2

Consensus Members
Id Members
7DFL 7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
Net Summary
Imin 2.94
Number of Linked Nodes 251
Number of Links 299
Number of Hubs 45
Number of Links mediated by Hubs 164
Number of Communities 9
Number of Nodes involved in Communities 65
Number of Links involved in Communities 95
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 51809
Length Of Smallest Path 3
Average Path Length 12.4035
Length of Longest Path 31
Minimum Path Strength 1.365
Average Path Strength 6.66047
Maximum Path Strength 19.01
Minimum Path Correlation 0.7
Average Path Correlation 0.922359
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.16667
Average % Of Corr. Nodes 54.633
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.451
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
h1_off_onh1_offh1_on
This network is also present in following consensuses:
IdComponents
histamine_onh1_on
h4_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download h1_on.zip



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