Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1Lig 9.154884120
2G.HN.36 5.778544
3G.hns1.01 7.9045134
4G.S1.02 3.395436
5G.S1.05 8.1975419
6G.S3.03 4.71638
7G.S3.04 8.96417
8G.S3.06 8.064517
9G.H2.01 9.175419
10G.H2.05 5.815418
11G.H2.06 6.75619
12G.H2.07 7.79419
13G.h2s4.01 8.8825419
14G.S4.03 2.82437
15G.S4.04 3.64857719
16G.H3.06 5.11406
17G.H3.09 4.65333919
18G.H3.12 2.735418
19G.H3.13 7.32667616
20G.H3.17 8.356515
21G.H3.18 5.99409
22G.S5.03 4.715439
23G.S5.04 2.925419
24G.S5.05 2.546539
25G.hgh4.02 2.91608
26G.hgh4.05 7.11406
27G.hgh4.08 9.385406
28G.hgh4.17 3.03414
29G.H4.04 2.785404
30G.H4.08 3.9225403
31G.H4.10 7.8875407
32G.H4.14 7.135405
33G.H4.15 5.438518
34G.h4s6.02 4.928517
35G.S6.01 4.126515
36G.S6.02 6.42286738
37G.S6.05 4.97515
38G.H5.05 4.775435
39G.H5.08 5.56667638
40G.H5.17 5.724535
41G.H5.20 3.626538
42G.H5.23 6.442534
43G.H5.26 3.264538
44b.1x14 4.044557
45b.1x18 6.476556
46b.h2x1 4.755405
47b.lhb1x3 3.8175492
48b.lhb1x6 3.625693
49b.b1x3 5.5775447
50b.b1x4 5.15447
51b.b1x6 9.6075449
52b.l1x3 8.52167649
53b.l1x6 12.445419
54b.b2x1 6.6125418
55b.b2x3 4.994546
56b.b2x5 6.24286747
57b.l2x5 7.14667645
58b.b3x2 5.8675445
59b.b3x3 4.48578
60b.l3x2 7.0125139
61b.b4x2 4.366508
62b.b4x3 3.624577
63b.b4x5 4.6175407
64b.b4x6 8.8275849
65b.b4x7 8.66448
66b.l4x2 7.51444
67b.l4x3 6.705446
68b.b5x2 8.0175447
69b.b5x3 6.78649
70b.l5x1 4.2925478
71b.l5x5 8.10833619
72b.b6x1 4.915419
73b.b6x5 4.03667676
74b.b7x1 4.3885114
75b.b7x2 3.695478
76b.b7x5 2.755409
77b.l7x2 3.752519
78b.l7x5 4.525406
79b.b8x1 2.4925408
80b.b8x3 3.34754116
81b.b8x4 4.99167676
82b.l9x3 6.69571789
83b.l9x6 4.46875818
84b.b10x2 4.04406
85b.b10x3 2.732508
86b.b10x4 5.1025406
87b.b10x5 3.887147119
88b.b11x4 5.4425489
89b.b11x5 3.64406
90b.b11x6 8.12489
91b.l11x2 7.68589
92b.b12x2 4.0775487
93b.b12x5 4.8525466
94b.b12x6 8.05167688
95b.b13x7 6.76333667
96b.l13x3 6.75769
97b.l13x6 7.3075419
98b.l13x7 4.685469
99b.b14x3 3.32465
100b.b15x1 6.32669
101b.b15x3 4.446569
102b.l15x1 4.644517
103b.l15x2 7.455469
104b.b16x4 8.765466
105b.b16x6 7.4768
106b.b17x5 6.698557
107b.b17x7 6.02667658
108b.l17x3 7.13875859
109b.l17x6 6.9675419
110b.b18x3 4.325458
111b.b18x5 7.22455
112b.l18x1 7.35857716
113b.l18x3 9.0175415
114b.b19x2 5.61856
115b.b19x4 5.496558
116b.l19x2 7.862559
117b.b20x2 7.294556
118b.b20x4 12.552558
119b.b20x6 6.88143756
120b.l20x1 3.5575456
121b.b21x1 8.78457
122b.b21x5 4.0425414
123b.b21x6 7.17451
124b.b21x7 4.69429715
125b.l21x5 3.638514
126b.l21x7 4.61415
127b.b22x1 4.635418
128b.b22x5 5.385417
129b.l22x4 2.635419
130b.l22x5 6.628599
131b.b23x5 2.36417
132b.b23x6 6.22286717
133b.l23x1 8.19416
134b.b24x3 4.07515
135b.b24x4 6.114516
136b.b24x5 3.798515
137b.b24x6 7.63418
138b.l24x3 3.1875405
139b.b25x3 6.4875415
140b.b25x7 5.91417
141b.l25x3 8.126519
142b.l25x5 2.9725417
143b.l25x6 11.844518
144b.l25x7 4.104517
145b.b26x3 3.955616
146b.l26x1 6.6275447
147b.b27x1 3.81416
148b.b27x3 6.5075418
149b.l27x1 11.1917619
150b.l27x2 6.8975419
151b.b28x3 4.944547
152b.b28x4 6.09416
153b.b28x6 6.555619
154g.h1x6 2.33833659
155g.l1x4 5.374558
156g.ctx3 5.81667609
157g.ctx6 3.44496
158g.ctx15 6.825449
159g.ctx16 5.8561048
160NT.I52 4.4325425
161NT.W69 7.575627
162NT.D70 7.65429
163NT.W72 10.336525
164NT.L73 7.02625
165NT.W75 6.84167629
166NT.C88 3.905409
167NT.Y91 4.88714725
168NT.F92 7.068526
169NT.D94 8.165425
170NT.F95 6.79525
171NT.D96 7.1675405
172NT.E99 5.31405
173NT.K103 11.7575428
174NT.W111 9.342529
175NT.H114 10.8225424
176NT.W121 8.465428
177NT.T122 10.32427
178NT.Y124 9.58143724
179NT.T125 4.6675426
1801x39 6.73526
1811x40 5.224526
1821x44 3.6825426
1831x54 3.748509
1841x57 4.5954128
1851x58 2.3225405
1861x61 4.4725407
1871x64 3.7025407
1882x45 12.5325437
1892x46 7.0175409
1902x53 6.695409
1912x54 5.03508
1922x57 7.46833628
1932x67 7.725407
194E1.P209 3.198525
1953x33 5.3925406
1963x34 3.3725406
1973x36 6.162526
1983x37 4.71427
1993x38 6.67408
2003x40 5.032526
2013x44 5.07667628
2023x45 3.6365165
2033x46 6.531676109
2043x47 2.7725429
2053x48 4.535168
2063x50 9.375409
2073x52 3.245406
2083x53 8.54833638
2093x55 11.8154178
210I2.F246 6.84833636
2114x50 5.0585109
2124x53 4.145409
2134x60 6.25833628
2144x64 8.822527
2154x68 6.696526
216E2x50 4.815429
217E2x51 10.34508
218E2.S285 6.32425
2195x36 3.965423
2205x53 10.1125408
2215x54 3.53254189
2225x61 2.8175438
2235x64 3.94167639
2245x65 4.53437
2256x49 5.6025189
2266x51 5.18254187
2276x52 6.304528
2286x53 7.022528
2297x37 7.0975426
2307x42 9.16667627
2317x45 5.545427
2327x46 9.252529
2337x49 6.016529
2347x54 4.63754128
2357x59 3.511676128
2368x53 3.344148
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.h2s4.01 b.l5x5 44.991313.03YesYes199
2G.H2.07 G.h2s4.01 80.22393.01YesYes199
3G.H2.07 G.S3.08 1008.58YesNo099
4G.S3.07 G.S3.08 1001.46NoNo099
5G.S1.06 G.S3.07 1004.07NoNo089
6G.S1.06 G.S3.05 51.30868.48NoNo088
7G.S1.04 G.S3.05 51.34382.83NoNo078
8G.S1.04 G.S3.03 1003.65NoYes078
9G.S1.02 G.S3.03 1003.39YesYes368
10G.H5.15 G.S1.02 1002.65NoYes386
11G.H5.15 G.H5.19 1002.65NoNo088
12G.H5.19 G.H5.22 31.17594.95NoNo084
132x46 G.H5.22 31.15327.01YesNo094
142x46 2x50 30.06744.51YesNo099
152x50 3x50 30.055612.31NoYes099
162x53 3x50 59.77776.63YesYes099
172x53 2x57 89.90287.31YesYes098
182x57 3x43 14.520121.75YesNo088
192x60 3x43 19.250312.26NoNo088
202x60 3x40 19.06585.61NoYes086
213x40 Lig 47.27068.08YesYes260
22G.S1.06 G.S4.03 54.60062.85NoYes087
23G.S1.04 G.S4.03 51.3222.85NoYes077
243x57 G.H5.19 71.316415.43NoNo088
253x53 3x57 71.26798.21YesNo388
262x49 3x53 70.70144.69NoYes098
272x49 3x50 30.143.98NoYes099
282x49 3x46 40.56735.69NoYes099
292x53 3x46 29.98677.97YesYes099
303x46 4x50 10.57257.5YesYes1099
312x57 3x47 30.00872.49YesYes289
323x44 3x47 29.88112.39YesYes289
333x40 3x44 28.67563.59YesYes268
342x57 7x49 45.58098.2YesYes289
353x44 7x49 29.88232.25YesYes289
363x44 7x45 30.92133.59YesYes287
377x45 Lig 45.0414.56YesYes270
386x53 7x49 15.633910.54YesYes289
396x53 7x45 18.11897.46YesYes287
40G.H2.10 b.l5x5 13.80152.61NoYes189
41G.H2.10 b.b2x1 13.7436.72NoYes188
42b.b2x1 b.l27x1 41.16835.79YesYes189
43b.b26x1 b.l27x1 12.0116.18NoYes099
44b.b26x1 b.b26x2 11.77063.44NoNo097
45b.b26x2 b.b2x3 11.29144.86NoYes076
46b.l3x1 b.l5x5 27.6686.57NoYes099
47b.b2x1 b.l3x1 13.74846.76YesNo089
48G.h2s4.01 b.l7x2 37.28532.44YesYes199
49b.b6x1 b.l7x2 13.78692.83YesYes199
50b.b2x1 b.b6x1 13.86727.18YesYes189
51b.l1x6 b.l3x1 13.869410.85YesNo099
52b.l1x6 b.l27x1 13.690720.89YesYes199
53b.l7x2 b.l9x6 23.44913.52YesYes198
54b.b10x1 b.l9x6 18.90162.54NoYes098
55b.b10x1 b.b11x5 18.84294.89NoYes096
56b.b10x2 b.b11x5 10.8633.44YesYes066
57G.H3.08 G.S4.04 16.10957.31NoYes089
58G.H2.04 G.H3.08 16.16984.86NoNo098
59G.H2.04 G.H2.07 16.23429NoYes199
60G.H3.09 G.S4.04 10.26224.29YesYes199
61G.H3.06 G.H4.15 10.26759.74YesYes068
62b.l25x6 b.l27x1 37.863422.99YesYes189
63b.l23x1 b.l25x6 13.941910.72YesYes168
64b.l21x7 b.l23x1 13.47343.11YesYes156
65b.b23x6 b.l21x7 12.0354.03YesYes175
66b.b22x1 b.l25x6 23.023410.35YesYes188
67b.b22x1 b.b22x2 10.78623.2YesNo188
68b.b22x2 b.b26x3 10.54686.01NoYes186
69b.b23x1 b.b24x5 12.93534.47NoYes055
70b.b23x1 b.lhb1x6 10.05962.98NoYes053
71b.b24x3 b.b25x7 11.02514.76YesYes157
72b.b24x5 b.b25x7 10.06492.98YesYes157
73Lig NT.G71 10.50193.01YesNo204
74NT.G71 NT.W69 10.04537.04NoYes247
75Lig NT.Y124 18.25883.55YesYes204
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
5x37Lig4.162NoYes5010
5x38Lig6.432NoYes6010
6x58Lig8.932NoYes5010
5x44Lig5.070NoYes4010
7x41Lig6.352NoYes8010
5x40Lig21.392NoYes6010
7x42Lig12.062YesYes7010
7x45Lig4.562YesYes7010
2x68Lig7.22NoYes7010
3x40Lig8.082YesYes6010
3x36Lig4.782YesYes6010
3x37Lig2.572YesYes7010
E2.S286Lig5.10NoYes7010
1x40Lig7.312YesYes6010
E1.A199Lig1.790NoYes4010
E2x52Lig3.382NoYes6010
1x32Lig2.822NoYes3010
1x36Lig3.160NoYes5010
1x37Lig4.362NoYes3010
E1.V205Lig4.852NoYes4010
LigNT.D907.152YesNo0301
LigNT.P974.322YesNo0301
E2.D287Lig2.382NoYes3010
1x33Lig9.642NoYes1010
LigNT.Q939.42YesNo0401
LigNT.D9420.12YesYes0501
1x30Lig2.770NoYes2010
LigNT.W7210.682YesYes0501
LigNT.F9214.272YesYes0601
LigNT.F9510.42YesYes0501
LigNT.Y1243.552YesYes0401
LigNT.T1253.172YesYes0601
LigNT.N1285.912YesNo0301
LigNT.H11415.342YesYes0401
LigNT.A1163.422YesNo0301
LigNT.S1174.892YesNo0401
LigNT.G713.012YesNo0401
NT.G71NT.W697.042NoYes4712
NT.D70NT.L732.712YesYes9522
NT.D70NT.T1228.672YesYes9722
NT.D70NT.Y1248.052YesYes9421
NT.W72NT.Y914.822YesYes5512
NT.F92NT.W727.022YesYes6511
NT.F95NT.W726.012YesYes5511
NT.W72NT.Y12423.152YesYes5411
NT.L73NT.V1014.472YesNo5722
NT.L73NT.Y1247.032YesYes5421
NT.D90NT.Y912.32NoYes3512
NT.F92NT.Y913.092YesYes6512
NT.D94NT.F922.392YesYes5611
NT.F92NT.F958.572YesYes6511
NT.D94NT.F954.782YesYes5511
NT.D94NT.N1285.392YesNo5311
NT.C127NT.F954.190NoYes9521
NT.D96NT.P976.440YesNo5321
1x32NT.D9612.442NoYes3512
NT.V101NT.Y12411.362NoYes7421
NT.H114NT.P1159.152YesNo4312
NT.A116NT.H1142.932NoYes3411
NT.H114NT.W12115.872YesYes4812
NT.R119NT.S1175.270NoNo4421
NT.N123NT.W12113.562NoYes8822
NT.T125NT.W1212.432YesYes6812
NT.T122NT.Y12411.242YesYes7421
NT.N123NT.T12510.242NoYes8621
NT.C127NT.Y1242.690NoYes9421
NT.Q126NT.T1252.830NoYes5621
1x311x322.70NoNo1321
1x331x372.982NoNo1311
1x391x422.772YesNo6622
1x397x384.072YesNo6622
1x397x42182YesYes6721
1x401x447.542YesYes6612
1x402x684.872YesNo6711
1x402x695.192YesNo6312
1x427x422.572NoYes6721
1x437x422.742NoYes7721
1x437x4617.82NoYes7922
1x442x693.042YesNo6322
2x602x642.920NoNo8722
2x603x405.610NoYes8621
2x633x364.150NoYes6621
2x643x369.580NoYes7621
2x673x338.650YesYes7622
2x673x368.360YesYes7621
E1.Q202E1.V2055.730NoNo2421
E1.V205E2x506.832NoYes4912
3x333x377.990YesYes6721
3x33E2x522.740YesNo6621
3x363x403.942YesYes6611
3x374x602.572YesYes7812
3x375x395.712YesNo7712
3x403x443.592YesYes6812
3x405x403.942YesNo6611
3x446x534.132YesYes8822
3x447x453.592YesYes8721
4x604x6411.282YesYes8722
4x605x372.572YesNo8521
4x605x3911.932YesNo8722
4x644x684.122YesYes7622
4x645x372.432YesNo7521
4x68E2.S28510.172YesYes6522
4x68E2.D2873.452YesNo6321
E2x50E2x523.272YesNo9621
E2.D287E2.S2854.422NoYes3512
5x355x388.710NoNo4621
6x537x457.462YesYes8721
6x587x353.272NoNo5412
6x587x3710.612NoYes5612
7x357x375.612NoYes4622
7x377x4110.782YesNo6821
7x387x4210.082NoYes6721
7x427x469.552YesYes7912
7x457x466.572YesYes7912
1x29Lig1.592NoYes1010
1x291x331.592NoNo1111
NT.N128NT.V1291.482NoNo3212
1x40E1.N2001.212YesNo6312
E3.R355Lig1.190NoYes4010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
91.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
48.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
48.48Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
48.48Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
48.48Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
48.39Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
46.88Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
46.88Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
45.71Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
45.71Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
45.45Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
45.16Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
44.74Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
42.42Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
41.94Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
41.18Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
41.18Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
39.39Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
39.39Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
39.39Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
39.39Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
39.39Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
37.84Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
37.50Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
37.14Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
37.14Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
37.14Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
36.59Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
36.36Consensuscalcitonin_onOrthosteric Ligandctlike_on
35.90Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
35.71Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
35.29Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
35.29Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
35.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
35.14Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
35.00Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
34.29Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
34.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
34.29Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
33.33Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
32.43Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
31.58Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
31.58Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
31.43Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
31.43Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
30.77Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
30.77Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
30.56Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
30.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
30.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
30.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
30.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
29.73Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
29.41Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
29.41Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
29.41Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
29.27Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
28.95Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
28.57Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
28.57Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
28.21Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
28.12Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
28.12Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
27.78Single6FJ3PTH6FJ3-PTH1-PTH
27.78Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
27.78Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
27.78Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
27.59Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
27.27Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
27.03Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
27.03Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
27.03Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
27.03Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
26.83Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
26.67Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
26.47Single5WF5UK-4320975WF5-A2A-UK-432097
26.47Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
26.47Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
26.47Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
26.32Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
26.32Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
26.32Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
26.32Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
26.32Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
26.32Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
26.19Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
25.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
25.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
25.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
25.71Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
25.64Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
25.53Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
25.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
25.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
25.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
25.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
25.00Consensuspac_onOrthosteric Ligandpac1_on
24.39Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.39Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
24.39Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
24.32Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.32Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
24.32Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
24.32Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
24.32Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
24.32Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
24.32Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
24.32Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
24.24Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
24.24Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
24.14Consensusa3_on_gpOrthosteric Liganda3a_on_gp
24.14Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
24.14Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.91Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
23.81Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.81Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
23.68Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.68Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
23.68Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
23.68Consensusglp_onOrthosteric Ligandglp1_on glp2_on
23.68Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
23.53Single3QAKUK-4320973QAK-A2A-UK-432097
23.53Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.53Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
23.53Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
23.53Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
23.53Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.53Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
23.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
23.33Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
23.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
23.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
23.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
23.08Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.08Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
23.08Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
23.08Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
23.08Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
23.08Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
22.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.86Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
22.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.58Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
22.58Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.50Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
22.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.22Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
22.22Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
22.22Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.95Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.88Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
21.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.88Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
21.88Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
21.62Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
21.62Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
21.62Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
21.43Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single5WF6UK-4320975WF6-A2A-UK-432097
21.21Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
21.05Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
21.05Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
21.05Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.05Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
21.05Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
20.93Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.93Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.69Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.69Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
20.69Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
20.69Consensusa3_onOrthosteric Liganda3a_on
20.59Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.59Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
20.59Single7QA8Peptide7QA8-STE2-Peptide
20.59Single7QA8Peptide7QA8-STE2-Peptide
20.59Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
20.59Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
20.59Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.59Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
20.59Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.59Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.59Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
20.51Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.51Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
20.51Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
20.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.00Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
20.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
20.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
20.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.00Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
20.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
20.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
20.00Consensusbradykinin_onOrthosteric Ligandbk2_on
20.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
20.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.44Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
19.44Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
19.44Consensusangiotensin_onOrthosteric Ligandat1_on
19.44Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
19.35Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.35Single7P2L4YI7P2L-mGlu5-4YI
19.35Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
19.35Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
19.35Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
19.35Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
19.35Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
19.35Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
19.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.35Single9AS9RS130-1809AS9-5-HT2A-RS130-180
19.35Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
19.35Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.35Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.35Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
19.23Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
18.92Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
18.92Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.92Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
18.92Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
18.92Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.92Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
18.92Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.92Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
18.92Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.92Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.92Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
18.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.92Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
18.75Single4XEENeurotensin4XEE-NTS1-Neurotensin
18.75Single4XESNeurotensin4XES-NTS1-Neurotensin
18.75Single6YVRNTS8-136YVR-NTS1-NTS8-13
18.75Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.75Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.75Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.75Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.75Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
18.75Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
18.75Single8XWMCXCL68XWM-CXCR2-CXCL6
18.75Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.75Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
18.52Single4O9RCyclopamine4O9R-SMO-Cyclopamine
18.52Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
18.42Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
18.42Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
18.42Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
18.42Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.42Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
18.42Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.42Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
18.18Single4BUONeurotensin4BUO-NTS1-Neurotensin
18.18Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
18.18Single7EZCUKA7EZC-A2A-UKA
18.18Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
18.18Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
18.18Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
18.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
18.18Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
18.18Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
18.18Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
18.18Single8XVUCXCL28XVU-CXCR2-CXCL2
18.18Single8XWFCXCL38XWF-CXCR2-CXCL3
18.18Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
18.18Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
18.18Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
18.18Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
17.95Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
17.95Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
17.95Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
17.95Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
17.95Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
17.86Single4QINSAG1.54QIN-SMO-SAG1.5
17.86Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
17.86Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.86Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
17.65Single3NY9ICI118-5513NY9-β2-ICI118-551
17.65Single4UG2CGS216804UG2-A2A-CGS21680
17.65Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.65Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
17.65Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.65Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
17.65Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
17.65Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
17.65Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.65Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
17.65Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
17.50Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
17.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
17.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
17.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
17.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.50Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
17.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
17.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
17.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
17.24Single2YDOAdenosine2YDO-A2A-Adenosine
17.24Single6FFIMMPEP6FFI-mGlu5-MMPEP
17.24Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
17.24Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.24Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
17.24Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
17.24Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
17.24Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
17.24Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
17.24Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
17.14Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
17.14Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
17.14Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
17.14Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
17.14Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.07Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.67Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.67Single5T04Neurotensin5T04-NTS1-Neurotensin
16.67Single6FFHFenobam6FFH-mGlu5-Fenobam
16.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
16.67Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
16.67Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
16.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
16.67Single7XNACYN1548067XNA-SST2-CYN154806
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
16.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
16.67Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.67Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
16.67Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
16.67Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
16.67Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
16.67Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
16.67Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
16.67Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
16.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
16.67Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Consensushca_on_gpOrthosteric Ligandhca2_on_gp
16.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
16.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
16.67Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
16.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
16.22Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.22Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
16.22Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.22Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
16.22Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.22Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.22Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
16.22Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
16.22Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
16.22Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
16.13Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
16.13Single5N2RPSB-365N2R-A2A-PSB-36-Na
16.13Single5N2SPSB365N2S-A1-PSB36
16.13Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.13Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
16.13Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
16.13Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
16.13Single7SINNPS-21437SIN-CaS-NPS-2143
16.13Single7SINNPS-21437SIN-CaS-NPS-2143
16.13Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.13Single8QOTNanobody-E8QOT-μ-Nanobody-E
16.13Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
16.13Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.13Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
16.13Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
16.13Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
16.13Single9HC04YI9HC0-mGlu5-4YI
16.13Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.13Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
16.13Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
16.13Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.00Single8HS2Fab0468HS2-GPR20-Fab046
15.91Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.79Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.79Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
15.79Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
15.79Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
15.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.79Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
15.79Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
15.79Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
15.79Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.79Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
15.79Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
15.62Single2YDVNECA2YDV-A2A-NECA
15.62Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
15.62Single4BV0Neurotensin4BV0-NTS1-Neurotensin
15.62Single4UHRCGS216804UHR-A2A-CGS21680
15.62Single5G53NECA5G53-A2A-NECA-Gs
15.62Single6J21Aprepitant6J21-NK1-Aprepitant
15.62Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
15.62Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
15.62Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
15.62Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.62Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
15.62Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.62Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.62Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
15.62Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.62Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.62Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
15.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
15.62Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
15.62Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
15.62Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
15.62Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
15.62Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.62Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
15.62Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
15.62Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
15.62Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.62Consensusa2_onOrthosteric Liganda2b_on
15.62Consensusa2_on_gpOrthosteric Liganda2b_on_gp
15.62Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.62Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.62Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.62Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.62Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
15.62Consensusneurotensin_onOrthosteric Ligandnts1_on
15.62Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.62Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.62Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
15.56Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.38Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
15.38Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
15.38Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.38Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
15.38Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
15.15Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
15.15Single4N4WSANT-14N4W-SMO-SANT-1
15.15Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
15.15Single5CXVTiotropium5CXV-M1-Tiotropium
15.15Single6OS2TRV0266OS2-AT1-TRV026
15.15Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
15.15Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
15.15Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
15.15Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
15.15Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.15Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
15.15Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.15Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
15.15Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
15.15Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
15.15Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8XWACXCL18XWA-CXCR2-CXCL1
15.15Single8XWSCXCL58XWS-CXCR2-CXCL5
15.15Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
15.15Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
15.15Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
15.15Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.15Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
15.15Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
15.15Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
15.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
14.81Single4XNWMRS25004XNW-P2Y1-MRS2500
14.81Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
14.81Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
14.81Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
14.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.81Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.71Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
14.71Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
14.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.71Single5CGDHTL142425CGD-mGlu5-HTL14242
14.71Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
14.71Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
14.71Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
14.71Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
14.71Single7UM4AS26747237UM4-5-HT5A-AS2674723
14.71Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
14.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.71Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.71Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
14.71Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
14.71Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.71Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
14.71Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
14.71Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
14.71Consensuscck_onOrthosteric Ligandccka_on cckb_on
14.71Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
14.71Consensuschemerin_onOrthosteric Ligandcml1_on
14.71Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
14.63Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.63Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.63Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
14.63Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
14.29Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.29Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
14.29Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.29Single7SK9CCX6627SK9-ACKR3-CCX662
14.29Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
14.29Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
14.29Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
14.29Single7XN9L-054,5227XN9-SST2-L-054,522
14.29Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
14.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
14.29Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
14.29Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
14.29Single8K5BNiacin8K5B-HCA2-Niacin
14.29Single8QJ2pN1628QJ2-MC4-pN162-Gs
14.29Single8XQJJN2418XQJ-Apelin-JN241
14.29Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.29Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
14.29Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
14.29Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
14.29Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
14.29Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
14.29Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
14.29Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.29Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.95Single5GLHEndothelin-15GLH-ETB-Endothelin-1
13.95Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.95Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.95Consensusbombesin_onOrthosteric Ligandbb2_on
13.95Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
13.95Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.89Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
13.89Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.89Single7F8XNN90567F8X-CCKA-NN9056
13.89Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
13.89Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
13.89Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
13.89Single8IEBA1LYA8IEB-GPR156-A1LYA
13.89Single8IEIA1LYA8IEI-GPR156-A1LYA
13.89Single8IEPA1LYA8IEP-GPR156-A1LYA
13.89Single8IEPA1LYA8IEP-GPR156-A1LYA
13.89Single8WDTphotoNECA8WDT-A2A-photoNECA
13.89Single8XWNCXCL88XWN-CXCR2-CXCL8
13.89Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
13.89Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
13.89Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
13.89Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.89Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
13.89Consensuslpl_onOrthosteric Ligands1p_on lpa_on
13.89Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
13.89Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
13.89Consensussomatostatin_offOrthosteric Ligandsst2_off
13.79Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.79Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
13.79Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
13.79Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
13.79Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.79Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
13.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
13.79Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
13.79Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
13.79Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
13.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
13.79Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
13.79Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.79Single8IWESpermidine8IWE-TA9-Spermidine
13.79Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
13.79Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
13.79Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.79Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
13.79Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.64Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.51Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.51Single6HLOAprepitant6HLO-NK1-Aprepitant
13.51Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.51Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.51Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.51Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.51Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
13.51Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
13.51Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
13.51Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
13.51Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
13.51Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
13.51Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.51Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.51Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.51Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.33Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
13.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
13.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.33Single5JTBZM-2413855JTB-A2A-ZM-241385
13.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
13.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
13.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
13.33Single5UVIZM-2413855UVI-A2A-ZM-241385
13.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
13.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
13.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
13.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.33Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
13.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
13.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
13.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
13.33Single7VV6C48/807VV6-MRGPRX2-C48/80
13.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
13.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
13.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
13.33Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
13.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
13.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
13.33Single8K5CAcipimox8K5C-HCA2-Acipimox
13.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
13.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
13.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
13.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
13.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
13.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
13.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
13.33Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
13.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
13.33Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
13.33Consensusa2_offOrthosteric Liganda2a_off
13.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
13.33Consensusgrh_offOrthosteric Ligandgnrh1_off
13.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.33Consensushca_onOrthosteric Ligandhca2_on
13.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.16Single3OE0CVX153OE0-CXCR4-CVX15
13.16Single6PT2KGCHM076PT2-δ-KGCHM07
13.16Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.16Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.16Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.16Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.16Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.16Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
13.16Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.16Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
12.90Single3EMLZM-2413853EML-A2A-ZM-241385
12.90Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
12.90Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.90Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
12.90Single4QIMANTA XV4QIM-SMO-ANTA XV
12.90Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
12.90Single5DSGTiotropium5DSG-M4-Tiotropium
12.90Single5IU8Q274563475IU8-A2A-Q27456347-Na
12.90Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
12.90Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
12.90Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
12.90Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
12.90Single5TGZAM65385TGZ-CB1-AM6538
12.90Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
12.90Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
12.90Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
12.90Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
12.90Single6S0LZM-2413856S0L-A2A-ZM-241385
12.90Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
12.90Single7PYRPSB-21157PYR-A2A-PSB-2115
12.90Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
12.90Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
12.90Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
12.90Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
12.90Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.90Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
12.90Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
12.90Single8K5DGSK2560738K5D-HCA2-GSK256073
12.90Single8T1WCVN4248T1W-GPR6-CVN424
12.90Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
12.90Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.90Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.90Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.90Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
12.90Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.90Single9AS1DMT9AS1-5-HT2A-DMT
12.90Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.90Single9JEAAtropine9JEA-M1-Atropine
12.90Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
12.90Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
12.90Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.90Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.90Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
12.90Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.90Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.90Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.90Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.90Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
12.90Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
12.82Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.82Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.82Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
12.82Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.82Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
12.82Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.82Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
12.82Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
12.82Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
12.82Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusvasop-oxy_onOrthosteric Ligandv2_on
12.82Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
12.50Single4JKVTaladegib4JKV-SMO-Taladegib
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.50Single5JQHS-Carazolol5JQH-β2-S-Carazolol
12.50Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
12.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
12.50Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
12.50Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
12.50Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.50Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
12.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.50Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
12.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.50Single6PS6Timolol6PS6-β2-Timolol
12.50Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
12.50Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.50Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.50Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
12.50Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.50Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
12.50Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
12.50Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.50Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
12.50Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
12.50Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
12.50Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
12.50Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
12.50Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
12.50Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
12.50Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
12.50Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
12.50Single8ZMFA1L108ZMF-5-HT2C-A1L10
12.50Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
12.50Single8ZRTET-18ZRT-ETB-ET-1
12.50Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
12.50Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
12.50Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
12.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
12.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
12.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.50Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
12.50Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.50Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
12.50Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.50Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
12.50Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
12.50Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
12.50Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.50Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Consensustrace-amine_onOrthosteric Ligandta1_on
12.20Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.20Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.20Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.20Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.20Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.12Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.12Single4U15Tiotropium4U15-M3-Tiotropium
12.12Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
12.12Single5V56TC1145V56-SMO-TC114
12.12Single5V57TC1145V57-SMO-TC114
12.12Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.12Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.12Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
12.12Single6OL9Tiotropium6OL9-M5-Tiotropium
12.12Single6OS1TRV0266OS1-AT1-TRV026
12.12Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.12Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
12.12Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.12Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.12Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.12Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
12.12Single7PX4PSB-21137PX4-A2A-PSB-2113
12.12Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.12Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.12Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
12.12Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.12Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.12Single8EA0Iperoxo8EA0-M3-Iperoxo
12.12Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.12Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.12Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
12.12Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.12Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.12Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
12.12Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
12.12Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
12.12Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
12.12Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.12Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
12.12Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.12Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.12Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.12Consensuslpa_onOrthosteric Ligandlpa1_on
12.12Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.12Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.12Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.12Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.12Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
12.12Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.12Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
11.90Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.90Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
11.90Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
11.76Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
11.76Single3D4STimolol3D4S-β2-Timolol
11.76Single4RWADIPP-NH24RWA-δ-DIPP-NH2
11.76Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
11.76Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
11.76Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
11.76Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
11.76Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
11.76Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
11.76Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.76Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.76Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
11.76Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
11.76Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
11.76Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
11.76Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.76Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
11.76Single8JWY2-1188JWY-A2A-2-118
11.76Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
11.76Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
11.76Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.76Single8XQJJN2418XQJ-Apelin-JN241
11.76Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.76Single8XYIVUF106618XYI-CXCR3-VUF10661
11.76Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
11.76Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
11.76Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.76Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.76Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.76Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.76Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
11.76Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
11.76Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
11.76Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
11.76Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.76Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
11.76Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.76Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
11.76Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
11.76Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
11.76Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.76Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.76Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.63Single6IGLIRL16206IGL-ETB-IRL1620
11.63Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
11.63Single8IY6Endothelin-18IY6-ETB-Endothelin-1
11.63Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusendothelin_onOrthosteric Ligandetb_on eta_on
11.63Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
11.54Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.54Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.54Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.43Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
11.43Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
11.43Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
11.43Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
11.43Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.43Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
11.43Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
11.43Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
11.43Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
11.43Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
11.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
11.43Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
11.43Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
11.43Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
11.43Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
11.43Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
11.43Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
11.43Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
11.43Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.43Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
11.43Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
11.36Single6IGKEndothelin-36IGK-ETB-Endothelin-3
11.11Single6KNMJN241-96KNM-Apelin-JN241-9
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single6PT3DPI-2876PT3-δ-DPI-287
11.11Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
11.11Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.11Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
11.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.11Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.11Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
11.11Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.11Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
11.11Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.11Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
11.11Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.11Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
11.11Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
11.11Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
11.11Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
11.11Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
11.11Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
11.11Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.81Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.81Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
10.81Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
10.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.81Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
10.81Single8IEIA1LYA8IEI-GPR156-A1LYA
10.81Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.81Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
10.81Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single9M4TSilodosin9M4T-Alpha1A-Silodosin
10.81Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.81Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
10.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.81Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.71Single3UZAGTPL92363UZA-A2A-GTPL9236
10.71Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.71Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.71Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.71Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.71Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.71Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
10.71Single8JPSCCL78JPS-ACKR1-CCL7
10.71Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
10.71Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.71Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.71Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.71Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
10.71Single9LRCHistamine9LRC-H4-Histamine
10.71Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
10.71Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.71Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.71Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.71Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.53Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.53Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
10.53Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
10.53Single7SK5CXCL127SK5-ACKR3-CXCL12
10.53Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
10.53Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
10.53Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
10.53Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.53Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.53Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
10.53Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.34Single6LI0C176LI0-GPR52-C17
10.34Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.34Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.34Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.34Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Single7UL2SR486927UL2-NTS1-SR48692-Na
10.34Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
10.34Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.34Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
10.34Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.34Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.34Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.34Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
10.34Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
10.34Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
10.34Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.34Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
10.34Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.34Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.34Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
10.34Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.34Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.34Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
10.34Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.34Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.34Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.34Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.34Consensusneurotensin_offOrthosteric Ligandnts1_off
10.34Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
10.26Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
10.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
10.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
10.26Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
10.26Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.26Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
10.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
10.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.20Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.20Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.00Single3PWHZM-2413853PWH-A2A-ZM-241385
10.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single5U09Taranabant5U09-CB1-Taranabant
10.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
10.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
10.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
10.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
10.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
10.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
10.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
10.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
10.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
10.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
10.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
10.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
10.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
10.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
10.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.00Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
9.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
9.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
9.68Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
9.68Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
9.68Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
9.68Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
9.68Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
9.68Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
9.68Single6AQFZM-2413856AQF-A2A-ZM-241385
9.68Single6MH8ZM-2413856MH8-A2A-ZM-241385
9.68Single6PS0S-Carazolol6PS0-β2-S-Carazolol
9.68Single6PS4ICI118-5516PS4-β2-ICI118-551
9.68Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.68Single7AROLUF58337ARO-A2A-LUF5833-Na
9.68Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.68Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
9.68Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.68Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
9.68Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
9.68Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
9.68Single7T32ZM-2413857T32-A2A-ZM-241385
9.68Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
9.68Single7UL3Famotidine7UL3-H2-Famotidine
9.68Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.68Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
9.68Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
9.68Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.68Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
9.68Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
9.68Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
9.68Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
9.68Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
9.68Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.68Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
9.68Single8IHKAcifran8IHK-HCA3-Acifran
9.68Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
9.68Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
9.68Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.68Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
9.68Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
9.68Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
9.68Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
9.68Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
9.68Single8ZPNAMD31008ZPN-CXCR4-AMD3100
9.68Single9ARXSerotonin9ARX-5-HT2A-Serotonin
9.68Single9AS3LSD9AS3-5-HT2A-LSD
9.68Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9AS5Mescaline9AS5-5-HT2A-Mescaline
9.68Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
9.68Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
9.68Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
9.68Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Consensusopsins_offOrthosteric Ligandrhodopsin_off
9.68Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Consensussensory_offOrthosteric Ligandopsins_off
9.52Single4XT3Fractalkine4XT3-US28-Fractalkine
9.52Single7SK3CXCL127SK3-ACKR3-CXCL12
9.38Single2Y04Salbutamol2Y04-β1-Salbutamol
9.38Single3NY8ICI118-5513NY8-β2-ICI118-551
9.38Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
9.38Single4DAJTiotropium4DAJ-M3-Tiotropium
9.38Single4GBRS-Carazolol4GBR-β2-S-Carazolol
9.38Single4MQSIperoxo4MQS-M2-Iperoxo
9.38Single4QKX35V4QKX-β2-35V
9.38Single4U14Tiotropium4U14-M3-Tiotropium
9.38Single5UENDU1725UEN-A1-DU172
9.38Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.38Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.38Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.38Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
9.38Single6H7MSalbutamol6H7M-β1-Salbutamol
9.38Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Single6PS1Timolol6PS1-β2-Timolol
9.38Single6TOTLemborexant6TOT-OX1-Lemborexant
9.38Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.38Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
9.38Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
9.38Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
9.38Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
9.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.38Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
9.38Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.38Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
9.38Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.38Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
9.38Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.38Single7UL4Alvimopan7UL4-μ-Alvimopan
9.38Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.38Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
9.38Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.38Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.38Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.38Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
9.38Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.38Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.38Single8CU6LJ-45178CU6-A2A-LJ-4517
9.38Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
9.38Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
9.38Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
9.38Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
9.38Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
9.38Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
9.38Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
9.38Single8JJOAlprenolol8JJO-β2-Alprenolol
9.38Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
9.38Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
9.38Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.38Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.38Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
9.38Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.38Single8X64Desloratadine8X64-H1-Desloratadine
9.38Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.38Single9CHXS-Carazolol9CHX-β2-S-Carazolol
9.38Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
9.38Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.38Single9H37A1IR09H37-A2A-A1IR0-Na
9.38Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.38Single9IYAONO-97105319IYA-GPR55-ONO-9710531
9.38Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
9.38Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
9.38Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Consensus5ht5_onOrthosteric Ligand5ht5a_on
9.38Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.38Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.38Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.38Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.38Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.38Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
9.38Consensusalpha2_onOrthosteric Ligandalpha2b_on
9.38Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
9.38Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusblt_onOrthosteric Ligandblt1_on
9.38Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.38Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.38Consensusdopamine_offOrthosteric Ligandd2_off d3_off
9.38Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
9.38Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
9.38Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.38Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.38Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.38Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.38Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
9.38Consensusleukotriene_onOrthosteric Ligandblt_on
9.38Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.30Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
9.30Single9KDFRES-701-39KDF-ETB-RES-701-3
9.09Single2RH1S-Carazolol2RH1-β2-S-Carazolol
9.09Single2Y03Isoprenaline2Y03-β1-Isoprenaline
9.09Single2YCWS-Carazolol2YCW-β1-S-Carazolol
9.09Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.09Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.09Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.09Single5C1MBU725C1M-μ-BU72
9.09Single5D6LS-Carazolol5D6L-β2-S-Carazolol
9.09Single5TVNLSD5TVN-5-HT2B-LSD
9.09Single5WIUNemonapride5WIU-D4-Nemonapride
9.09Single5WIVNemonapride5WIV-D4-Nemonapride-Na
9.09Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
9.09Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.09Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.09Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6TP6Filorexant6TP6-OX1-Filorexant
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
9.09Single7C61Ergotamine7C61-5-HT1B-Ergotamine
9.09Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
9.09Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
9.09Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single7WC6LSD7WC6-5-HT2A-LSD
9.09Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
9.09Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
9.09Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.09Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
9.09Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.09Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.09Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.09Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
9.09Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8S4DCMF-0198S4D-Apelin-CMF-019
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.09Single8TF5Oleic acid8TF5-GPR6-Oleic acid
9.09Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
9.09Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
9.09Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
9.09Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.09Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
9.09Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
9.09Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
9.09Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
9.09Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
9.09Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.09Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
9.09Consensusamine_offonOrthosteric Ligandamine_off amine_on
9.09Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
9.09Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
9.09Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
9.09Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
9.09Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.09Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.09Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.09Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
9.09Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.89Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
8.89Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.82Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
8.82Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
8.82Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
8.82Single5D5AS-Carazolol5D5A-β2-S-Carazolol
8.82Single5D5BS-Carazolol5D5B-β2-S-Carazolol
8.82Single5TZRMK86665TZR-FFA1-MK8666
8.82Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
8.82Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.82Single6J20Aprepitant6J20-NK1-Aprepitant
8.82Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
8.82Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.82Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.82Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.82Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.82Single6WGTLSD6WGT-5-HT2A-LSD
8.82Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.82Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
8.82Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.82Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
8.82Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
8.82Single7TUYGSK682753A7TUY-GPR183-GSK682753A
8.82Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
8.82Single8E0GBU728E0G-μ-BU72
8.82Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
8.82Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
8.82Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.82Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
8.82Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8.82Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.82Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
8.82Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
8.82Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.82Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
8.82Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
8.82Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
8.82Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
8.82Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
8.82Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
8.82Single9BJKNaloxone9BJK-μ-Naloxone-NAM
8.82Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
8.82Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
8.82Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.82Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.82Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
8.82Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.82Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.82Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
8.82Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
8.82Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
8.82Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.82Consensustachykinin_offOrthosteric Ligandnk1_off
8.70Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
8.70Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.57Single4AMIBucindolol4AMI-β1-Bucindolol
8.57Single4LDEBI1671074LDE-β2-BI167107
8.57Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.57Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
8.57Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
8.57Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
8.57Single6A93Risperidone6A93-5-HT2A-Risperidone
8.57Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.57Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
8.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
8.57Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.57Single6MXTSalmeterol6MXT-β2-Salmeterol
8.57Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
8.57Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.57Single7DFPSpiperone7DFP-D2-Spiperone
8.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
8.57Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
8.57Single7K15MKD0467K15-BLT1-MKD046-Na
8.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
8.57Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.57Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.57Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
8.57Single7YITNalfurafine7YIT-κ-Nalfurafine
8.57Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.57Single8JJ8Formoterol8JJ8-β2-Formoterol
8.57Single8JWZAB9288JWZ-A2A-AB928-Na
8.57Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
8.57Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
8.57Single9DGIZ85267113509DGI-CB1-Z8526711350
8.57Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
8.57Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.57Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
8.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.57Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.57Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.57Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.57Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.57Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
8.57Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
8.57Consensuslpa_offOrthosteric Ligandlpa1_off
8.57Consensuslpl_offOrthosteric Ligands1p_off lpa_off
8.57Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.57Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.57Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.57Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
8.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.33Single6H7LDobutamine6H7L-β1-Dobutamine
8.33Single6IBLArformoterol6IBL-β1-Arformoterol
8.33Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
8.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
8.33Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.33Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.33Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XVJMacitentan8XVJ-ETA-Macitentan
8.33Single8ZPLHF511168ZPL-CXCR4-HF51116
8.33Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
8.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.33Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
8.33Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
8.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
8.33Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
8.33Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
8.33Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
8.33Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single5ZTYAM102575ZTY-CB2-AM10257
8.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.11Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.11Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.11Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
8.11Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.11Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
8.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.11Single8X5YAstemizole8X5Y-H1-Astemizole
8.11Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single9JF4PD1683689JF4-BB1-PD168368
8.11Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
8.11Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.11Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
7.89Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
7.89Single4XT1Fractalkine4XT1-US28-Fractalkine
7.89Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.89Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
7.89Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.89Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.89Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
7.89Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
7.89Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
7.89Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.89Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
7.89Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
7.89Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
7.89Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.89Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.89Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
7.89Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.69Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
7.69Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.69Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.69Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
7.69Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
7.50Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.50Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.50Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
7.50Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
7.50Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.50Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.50Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.41Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
7.41Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.41Single8PWNTheophylline8PWN-A2A-Theophylline
7.41Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.32Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
7.32Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
7.14Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
7.14Single3RFMCaffeine3RFM-A2A-Caffeine
7.14Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
7.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.14Single8A2OTheophylline8A2O-A2A-Theophylline-Na
7.14Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
7.14Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
7.14Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
7.14Consensussensory_onOrthosteric Ligandopsins_on
6.98Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
6.90Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
6.90Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.90Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.90Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.90Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.90Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.90Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
6.90Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.90Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.90Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
6.90Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
6.90Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.90Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.67Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
6.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
6.67Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
6.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
6.67Single3OE9IT1t3OE9-CXCR4-IT1t
6.67Single3PBLEticlopride3PBL-D3-Eticlopride
6.67Single6HLLCP999946HLL-NK1-CP99994
6.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
6.67Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.67Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.67Single7SRQLSD7SRQ-5-HT2B-LSD
6.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
6.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.67Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
6.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
6.67Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AS7Psilocin9AS7-5-HT2A-Psilocin
6.67Single9B9Y7DY9B9Y-CB1-7DY
6.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.67Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
6.67Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
6.67Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
6.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.52Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.45Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
6.45Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
6.45Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
6.45Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
6.45Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.45Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
6.45Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.45Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.45Single6B73MP11046B73-κ-MP1104
6.45Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
6.45Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.45Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
6.45Single6TODEMPA6TOD-OX1-EMPA-Na
6.45Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.45Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.45Single7F8ULintitript7F8U-CCKA-Lintitript
6.45Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.45Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.45Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.45Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.45Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
6.45Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.45Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
6.45Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
6.45Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
6.45Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
6.45Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
6.45Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
6.45Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.45Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.45Single8GNGIstradefylline8GNG-A2A-Istradefylline
6.45Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.45Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
6.45Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.45Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
6.45Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
6.45Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.45Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.45Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
6.45Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
6.45Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.45Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.45Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.45Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
6.45Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.45Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.45Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
6.45Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
6.45Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.45Consensusangiotensin_offOrthosteric Ligandat1_off
6.45Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.45Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.45Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.45Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.45Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
6.45Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.45Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
6.25Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
6.25Single3REYXAC3REY-A2A-XAC
6.25Single3RZECidoxepin3RZE-H1-Cidoxepin
6.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.25Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.25Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.25Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
6.25Single6A94Zotepine6A94-5-HT2A-Zotepine
6.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.25Single6KUXRS-799486KUX-α2a-RS-79948
6.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
6.25Single6PS5S-Propranolol6PS5-β2-S-Propranolol
6.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.25Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.25Single6TPGEMPA6TPG-OX2-EMPA
6.25Single6TPKRetosiban6TPK-OT-Retosiban
6.25Single6V9SGTPL114036V9S-OX1-GTPL11403
6.25Single6VI4JDTic6VI4-κ-JDTic
6.25Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.25Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
6.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
6.25Single6ZG9GSK10347026ZG9-M1-GSK1034702
6.25Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.25Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.25Single7F61PF-036547467F61-H3-PF-03654746
6.25Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
6.25Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.25Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
6.25Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.25Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.25Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.25Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
6.25Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
6.25Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.25Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
6.25Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
6.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9BA0A1AKN9BA0-CB1-A1AKN
6.25Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.25Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
6.25Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
6.25Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.25Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
6.25Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
6.25Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
6.25Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.25Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.25Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.25Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.25Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.25Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
6.25Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
6.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
6.25Consensusvasop-oxy_offOrthosteric Ligandot_off
6.06Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
6.06Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
6.06Single2Y01Dobutamine2Y01-β1-Dobutamine
6.06Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
6.06Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
6.06Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
6.06Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
6.06Single4YAYZD-71554YAY-AT1-ZD-7155
6.06Single5DHGC-355DHG-NOP-C-35
6.06Single5DHHSB-6121115DHH-NOP-SB-612111
6.06Single5UIGCmpd-15UIG-A2A-Cmpd-1
6.06Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
6.06Single6D27CAY104716D27-DP2-CAY10471
6.06Single6DRXLisuride6DRX-5-HT2B-Lisuride
6.06Single6GPSMK08126GPS-CCR2-MK0812
6.06Single6IIVDaltroban6IIV-TXA2-Daltroban
6.06Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6.06Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
6.06Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
6.06Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
6.06Single7BU7BI1671077BU7-β1-BI167107
6.06Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
6.06Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
6.06Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.06Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.06Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
6.06Single7WC7Lisuride7WC7-5-HT2A-Lisuride
6.06Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.06Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
6.06Single7YXAONO-54306087YXA-S1P5-ONO-5430608
6.06Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
6.06Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.06Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
6.06Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
6.06Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
6.06Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
6.06Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.06Single8JXRLSD8JXR-D1-LSD
6.06Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
6.06Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
6.06Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
6.06Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
6.06Single8X63Mepyramine8X63-H1-Mepyramine
6.06Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.06Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
6.06Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
6.06Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
6.06Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
6.06Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
6.06Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
6.06Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
6.06Consensuscck_offOrthosteric Ligandccka_off
6.06Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.06Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
6.06Consensushistamine_offOrthosteric Ligandh1_off
6.06Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
5.88Single2Y00Dobutamine2Y00-β1-Dobutamine
5.88Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
5.88Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
5.88Single5WQCEMPA5WQC-OX2-EMPA
5.88Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
5.88Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
5.88Single6D26Fevipiprant6D26-DP2-Fevipiprant
5.88Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.88Single6GPXMK08126GPX-CCR2-MK0812
5.88Single6HLPNetupitant6HLP-NK1-Netupitant
5.88Single6Z4SSR486926Z4S-NTS1-SR48692
5.88Single7C4SS1P7C4S-S1P3-S1P
5.88Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
5.88Single7W41PD1762527W41-BB2-PD176252
5.88Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.88Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.88Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.88Single8JXSPF-61428JXS-D1-PF-6142
5.88Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.88Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
5.88Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.88Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
5.88Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9EHSLUF76029EHS-A3A-LUF7602
5.88Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
5.88Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
5.88Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.88Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
5.88Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.88Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
5.88Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
5.88Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
5.88Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
5.88Consensusblt_offOrthosteric Ligandblt1_off
5.88Consensusbombesin_offOrthosteric Ligandbb2_off
5.88Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.88Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
5.88Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
5.88Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.88Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
5.88Consensusdp_offOrthosteric Liganddp2_off
5.88Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
5.88Consensusep_offOrthosteric Ligandep4_off
5.88Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
5.71Single3P0GBI1671073P0G-β2-BI167107
5.71Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
5.71Single4DJHJDTic4DJH-κ-JDTic
5.71Single5XR8AM8415XR8-CB1-AM841
5.71Single5XRAAM115425XRA-CB1-AM11542
5.71Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
5.71Single6E59L-7607356E59-NK1-L-760735
5.71Single6TQ7SB-3348676TQ7-OX1-SB-334867
5.71Single7B6WCyclazosin7B6W-α1b-Cyclazosin
5.71Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
5.71Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.71Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.71Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
5.71Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
5.71Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
5.71Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
5.71Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.71Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
5.71Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.71Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
5.71Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
5.71Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
5.71Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
5.71Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
5.71Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
5.71Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.71Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
5.71Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
5.56Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
5.56Single5X33BIIL2605X33-BLT1-BIIL260
5.56Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
5.56Single6CM4Risperidone6CM4-D2-Risperidone
5.56Single6IIURamatroban6IIU-TXA2-Ramatroban
5.56Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
5.56Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
5.56Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.56Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.56Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8JJLOlodaterol8JJL-β2-Olodaterol
5.56Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.56Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
5.56Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
5.56Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.56Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.56Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
5.56Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
5.56Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
5.56Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
5.56Consensusorexin_onOrthosteric Ligandox2_on
5.41Single5X93K-87945X93-ETB-K-8794
5.41Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
5.41Single6K1QIRL25006K1Q-ETB-IRL2500
5.41Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
5.41Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
5.41Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.41Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
5.41Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
5.41Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
5.41Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
5.41Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
5.41Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.41Consensusendothelin_offOrthosteric Ligandetb_off
5.41Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
5.41Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
5.26Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
5.26Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
5.26Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.13Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.13Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
5.13Single8WKYPG-9348WKY-MC4-PG-934
5.13Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.13Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
4.88Single6W25SHU91196W25-MC4-SHU9119-Ca
4.65Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.44Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
4.44Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WVXNorrin8WVX-LGR4-Norrin
4.17Single8WVYNorrin8WVY-LGR4-Norrin
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9KHHNorrin9KHH-LGR4-Norrin
4.17Single9S37NB219S37-LGR4-NB21
4.17Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
3.70Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
3.70Single5MZPCaffeine5MZP-A2A-Caffeine-Na
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.70Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.70Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
3.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.57Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
3.57Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
3.57Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.45Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.45Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
3.45Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
3.45Single9CHUNoradrenaline9CHU-β2-Noradrenaline
3.45Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.45Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.33Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.33Single3OE6IT1t3OE6-CXCR4-IT1t
3.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
3.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.33Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
3.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
3.33Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.33Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
3.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.23Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.23Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.23Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.23Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
3.23Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
3.23Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
3.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.23Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.23Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.23Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.23Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
3.23Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
3.23Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
3.23Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
3.23Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
3.23Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
3.23Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
3.12Single3ODUIT1t3ODU-CXCR4-IT1t
3.12Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.12Single5WS3EMPA5WS3-OX2-EMPA
3.12Single6AKXA4R6AKX-CCR5-A4R
3.12Single6AKYMaraviroc6AKY-CCR5-Maraviroc
3.12Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.12Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
3.12Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.12Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.12Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.12Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
3.12Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
3.12Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
3.12Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
3.12Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.12Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.12Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
3.12Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
3.12Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
3.12Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
3.12Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Consensusorexin_offOrthosteric Ligandox2_off ox1_off
3.12Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
3.12Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
3.03Single4MBSMaraviroc4MBS-CCR5-Maraviroc
3.03Single6IQLL7458706IQL-D4-L745870
3.03Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
3.03Single6TPNHTL66416TPN-OX2-HTL6641
3.03Single6ZINSR486926ZIN-NTS1-SR48692
3.03Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
3.03Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.03Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
3.03Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single8IYXYL-3658IYX-GPR34-YL-365
3.03Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.03Single8K2WAMG4878K2W-CXCR3-AMG487
3.03Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
3.03Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
3.03Single8RLNLUF58348RLN-A2A-LUF5834
3.03Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.03Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
3.03Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
3.03Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.03Single8ZPMAMD0708ZPM-CXCR4-AMD070
3.03Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.03Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
3.03Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
3.03Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
3.03Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
2.94Single2Y02Carmoterol2Y02-β1-Carmoterol
2.94Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.94Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
2.94Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
2.94Single7F83PF-051904577F83-Ghrelin-PF-05190457
2.94Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
2.94Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
2.94Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
2.94Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
2.94Single7V3ZCP559407V3Z-CB1-CP55940
2.94Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
2.94Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.94Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
2.94Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
2.94Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
2.94Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
2.94Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
2.86Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
2.86Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
2.86Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.78Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
2.78Single7FEECP559407FEE-CB1-CP55940-ZCZ011
2.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
2.78Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
2.78Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
2.78Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
2.78Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
2.78Single8XVLZibotentan8XVL-ETA-Zibotentan
2.78Single8ZWFJR14a8ZWF-C3aB-JR14a
2.78Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Single6KQICP559406KQI-CB1-CP55940-Org27569
2.70Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single9BJKNAM9BJK-μ-Naloxone-NAM
2.70Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.63Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
2.56Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
2.56Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.56Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
2.56Single9IPYJR14a9IPY-C3aB-JR14a
2.56Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
2.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
2.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
2.50Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.44Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.38Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.17Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
6E3Y 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
Net Summary
Imin 1.77
Number of Linked Nodes 870
Number of Links 1204
Number of Hubs 236
Number of Links mediated by Hubs 871
Number of Communities 18
Number of Nodes involved in Communities 356
Number of Links involved in Communities 573
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 18795933
Length Of Smallest Path 3
Average Path Length 36.1867
Length of Longest Path 45
Minimum Path Strength 1.215
Average Path Strength 7.31081
Maximum Path Strength 22.84
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 37.8921
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 66.6087
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
calcitonin_on_gpctlike_on_gp



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