Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.969231320
2M:M:?1 8.283641110
3R:R:L26 4.518545
4R:R:L32 5.15105
5R:R:V40 6.625446
6R:R:H41 6.34648
7R:R:C50 4.4225449
8R:R:V53 4.6425403
9R:R:R57 6.444524
10R:R:R61 5.89824
11R:R:E63 5.535448
12R:R:M65 4.166549
13R:R:L66 3.92445
14R:R:R71 7.8675447
15R:R:I72 6.6825449
16R:R:L78 6.125447
17R:R:V82 4.82754105
18R:R:L84 3.70167609
19R:R:H87 5.866524
20R:R:I88 3.99833647
21R:R:L89 5.804525
22R:R:D90 8.4425449
23R:R:C92 7.0625448
24R:R:L103 5.9875405
25R:R:F105 6.00167626
26R:R:I136 4.482526
27R:R:V139 4.02427
28R:R:I140 4.8075447
29R:R:S143 4.83833624
30R:R:Y144 5.13571723
31R:R:S148 3.926527
32R:R:L154 3.4265175
33R:R:L157 4.6056115
34R:R:F158 7.284116
35R:R:Q162 6.225428
36R:R:I163 3.9525447
37R:R:Y165 8.142528
38R:R:A166 3.905425
39R:R:L172 8.2625427
40R:R:Y178 6.635406
41R:R:Y180 9.29754236
42R:R:F181 7.88333629
43R:R:R183 7.662529
44R:R:P186 4.472528
45R:R:P187 8.9525427
46R:R:D188 6.815428
47R:R:F190 4.9075425
48R:R:Q191 5.79528
49R:R:M195 3.714527
50R:R:Y206 11.48754259
51R:R:Y216 10.828527
52R:R:I221 5.4975405
53R:R:R231 5.7825404
54R:R:E239 6.2145265
55R:R:V241 4.72426
56R:R:M245 8.5775423
57R:R:L257 5.32754267
58R:R:K260 6.26254254
59R:R:V265 4.2825408
60R:R:F269 4.45527
61R:R:R271 13.845425
62R:R:D274 7.558524
63R:R:L279 3.705405
64R:R:F289 6.24406
65R:R:W291 5.50143787
66R:R:S294 5.47428
67R:R:W297 7.07429786
68R:R:E312 5.8025485
69R:R:Y322 8.3475423
70R:R:F327 6.486548
71R:R:F331 5.58546
72R:R:P336 8.194546
73R:R:N342 5.21833647
74R:R:P343 5.81442
75R:R:W344 6.66744
76R:R:F345 6.27833644
77R:R:W349 11.138548
78R:R:F357 8.592543
79R:R:F372 6.47667645
80R:R:Q374 5.3825445
81R:R:E375 4.855425
82R:R:K377 5.3675423
83R:R:F380 6.34833626
84R:R:V385 3.93449
85R:R:M395 6.6754105
86R:R:L406 7.53254102
87R:R:L418 3.414107
88R:R:Y419 5.802505
89R:R:F422 5.033336104
90R:R:F428 9.292508
91R:R:P431 8.1825447
92R:R:F432 7.13167644
93R:R:R433 5.865423
94R:R:D448 7.96333627
95R:R:R452 5.89754284
96R:R:Y453 5.385428
97R:R:N454 6.03254287
98R:R:I455 3.362508
99R:R:T457 5408
100R:R:Y458 10.6325485
101R:R:Y466 10.5402
102R:R:Y468 6.275684
103R:R:W474 5.814246
104R:R:L478 5.4454246
105R:R:W487 6.158587
106R:R:Y528 17.0954188
107R:R:E529 12.02754188
108R:R:Y530 14.65254197
109R:R:C540 6.49754199
110R:R:Y544 5.7745194
111R:R:Y560 14.16254306
112R:R:W563 10.61754305
113R:R:V590 2.72404
114R:R:H592 12.1754314
115R:R:L605 6.8125408
116R:R:Y617 7.3375408
117R:R:F623 6.49608
118R:R:P627 7.255409
119R:R:C632 5.2469
120R:R:R635 6.922508
121R:R:R636 8.29468
122R:R:L637 3.875344
123R:R:L639 11.91754338
124R:R:F643 8.77754338
125R:R:Y647 12.194206
126R:R:T652 7.0354327
127R:R:K653 8.23499
128R:R:T654 4.625499
129R:R:V716 4.995465
130R:R:T718 5.885466
131R:R:N722 6.255406
132R:R:R724 6.62167668
133R:R:Y745 5.705407
134R:R:T749 5.5775498
135R:R:R750 4.6325409
136R:R:N755 4.8375497
137R:R:F761 5.07595
138R:R:I762 4.908599
139R:R:W773 4.434509
140R:R:F776 4.35509
141R:R:T783 6.4075467
142R:R:Y787 7.16465
143R:R:Q790 4.255467
144R:R:L806 3.4175408
145S:S:E32 9.7575414
146S:S:I33 5.43833635
147S:S:L39 3.94505
148S:S:L44 4.192517
149S:S:P46 4.73416
150S:S:I47 6.782535
151S:S:N48 5.248539
152S:S:I60 3.585434
153S:S:R64 7.9825415
154S:S:Q67 5.57437
155S:S:R68 5.6925814
156S:S:L69 4.496535
157S:S:E70 5.23638
158S:S:M72 4.8675407
159S:S:L73 3.738534
160S:S:F74 9.7975437
161S:S:L85 4.872536
162S:S:L86 4.5575409
163S:S:L91 3.7975408
164S:S:V93 3.915407
165S:S:H94 9.465414
166S:S:I95 5.706537
167S:S:L96 7.03414
168S:S:D97 6.4875438
169S:S:C99 7.5275436
170S:S:R101 5.772533
171S:S:Y104 10.0375433
172S:S:L106 4.6254115
173S:S:L110 3.2075405
174S:S:F112 5.695615
175S:S:I146 4.83754217
176S:S:S149 4.635615
177S:S:Y150 5.19414
178S:S:V157 5.6275415
179S:S:L161 5.3175417
180S:S:L163 4.31754175
181S:S:P167 4.2408
182S:S:I169 4.8054217
183S:S:Y171 8.224516
184S:S:A172 3.905415
185S:S:L178 6.924518
186S:S:R183 10.125405
187S:S:Y186 8.09754366
188S:S:F187 8.668518
189S:S:R189 7.798519
190S:S:P192 5.375418
191S:S:P193 9.746518
192S:S:D194 7.7675418
193S:S:Y196 9.2225414
194S:S:Q197 5.55619
195S:S:L205 4.57476
196S:S:R206 2.64405
197S:S:W210 7.85167679
198S:S:Y212 5.755139
199S:S:V213 4.2625478
200S:S:T215 4.6825406
201S:S:Y222 11.9083617
202S:S:E233 6.06254375
203S:S:R237 4.7085374
204S:S:E245 4.916515
205S:S:V247 4.08833615
206S:S:Y256 9.58412
207S:S:V259 3.25667616
208S:S:K266 4.2154133
209S:S:V271 5.134578
210S:S:L274 3.678515
211S:S:F275 10.566518
212S:S:M276 4.00429714
213S:S:D280 6.405614
214S:S:L284 3.506515
215S:S:I285 4.23414
216S:S:R290 7.9825403
217S:S:F295 5.725419
218S:S:W297 5.74714717
219S:S:W303 8.48167617
220S:S:I309 7.37414
221S:S:E314 4.81414
222S:S:V316 3.2675404
223S:S:T322 4.81417
224S:S:Q328 4.3925403
225S:S:F333 6.34333637
226S:S:D334 7.5125434
227S:S:Y336 5.744538
228S:S:F337 8.0025436
229S:S:P342 8.4375435
230S:S:R347 4.92403
231S:S:N348 5.63857737
232S:S:P349 5.645432
233S:S:W350 8.24667635
234S:S:F351 7.595635
235S:S:F354 8.765436
236S:S:W355 10.795437
237S:S:Y384 6.51635
238S:S:Q386 6.3825436
239S:S:E387 4.13405
240S:S:K389 6.5375414
241S:S:M391 5.1775417
242S:S:F392 5.51333617
243S:S:N395 3.9508
244S:S:Y398 11.8575438
245S:S:M400 3.7554216
246S:S:H405 7.4875406
247S:S:C412 3.544224
248S:S:M422 3.4425223
249S:S:Y431 6.692505
250S:S:Y434 6.6625405
251S:S:L435 4.3407
252S:S:F440 10.48408
253S:S:F444 6.99333635
254S:S:F459 3.9775416
255S:S:D461 8.13667618
256S:S:Y466 5.114519
257S:S:N467 5.8417
258S:S:V468 3.55407
259S:S:F469 5.3725415
260S:S:N470 4.5375478
261S:S:F471 4.94515
262S:S:Q472 8.72406
263S:S:Y478 7.98413
264S:S:Y480 5.7325414
265S:S:V483 4.605478
266S:S:W486 7.108505
267S:S:L490 6.605406
268S:S:W499 8.614577
269S:S:P505 6.3475477
270S:S:C509 5.824139
271S:S:M518 5.464396
272S:S:C528 4.57254139
273S:S:Y537 6.694148
274S:S:E538 5.84147
275S:S:Y539 5.37254408
276S:S:Q553 3.055404
277S:S:Y569 6.962557
278S:S:R571 7.1125457
279S:S:W572 7.39571755
280S:S:Y616 6.12754157
281S:S:L619 3.9565159
282S:S:G621 3.0325408
283S:S:Y626 10.944558
284S:S:M628 6.874557
285S:S:T629 5.126557
286S:S:F632 11.042558
287S:S:R644 5.9275408
288S:S:L648 8.7025458
289S:S:F652 8.3475458
290S:S:Y656 8.956557
291S:S:F690 3.165404
292S:S:I708 5.2125403
293S:S:P712 4.0154168
294S:S:K733 4.801676166
295S:S:L738 8.1825455
296S:S:L741 6.4375457
297S:S:T752 4.435459
298S:S:F756 5.8075458
299S:S:R759 6.722559
300S:S:P762 5.0375459
301S:S:E763 7.3775458
302S:S:E767 10.545459
303S:S:F770 5.485404
304S:S:I771 7.185459
305S:S:M775 6.2459
306S:S:W782 9.15333659
307S:S:F785 7.1525409
308S:S:Y796 6.245455
309S:S:R797 6.1775455
310S:S:M803 4.126558
311S:S:V807 3.6225458
312S:S:V813 5.95254428
313S:S:L815 4.42254158
314S:S:F819 7.2145159
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1S:S:W486 S:S:Y466 10.7982.89YesYes059
2S:S:L178 S:S:R189 10.01356.07YesYes189
3S:S:I155 S:S:L178 35.64884.28NoYes058
4S:S:I155 S:S:Y184 58.28789.67NoNo056
5S:S:R183 S:S:Y184 56.71674.12YesNo056
6R:R:R177 S:S:R183 56.872321.32NoYes055
7R:R:R177 R:R:Y178 57.06337.2NoYes056
8R:R:I149 R:R:Y178 71.17916.04NoYes056
9R:R:I149 R:R:K171 70.80132.91NoNo053
10R:R:D215 R:R:K171 70.85334.15NoNo053
11L:L:?1 R:R:D215 70.90668.34YesNo005
12L:L:?1 R:R:Y216 49.63829.62YesYes207
13L:L:?1 R:R:R61 21.76494.15YesYes204
14L:L:?1 R:R:S143 13.46553.08YesYes204
15L:L:?1 R:R:D188 47.35233.71YesYes208
16M:M:?1 S:S:R68 10.01063.32YesYes104
17M:M:?1 S:S:S151 44.843611.28YesNo009
18M:M:?1 S:S:R277 32.40367.47YesNo104
19R:R:R61 R:R:Y165 13.28687.2YesYes248
20R:R:F38 R:R:Y165 26.002816.5NoYes088
21R:R:F38 R:R:M65 25.82696.22NoYes089
22R:R:I88 R:R:M65 18.0654.37YesYes479
23R:R:S143 R:R:Y165 13.24655.09YesYes248
24R:R:E375 R:R:H56 16.52054.92YesNo053
25R:R:H56 R:R:Q60 16.33998.65NoNo037
26R:R:F331 R:R:Q60 14.66473.51YesNo467
27R:R:E63 R:R:F331 13.84214.66YesYes486
28R:R:F345 R:R:N342 19.86594.83YesYes447
29R:R:N153 R:R:Y178 16.80599.3NoYes056
30R:R:D188 R:R:Q191 47.40576.53YesYes288
31R:R:Q191 R:R:Y216 47.37245.64YesYes287
32R:R:D295 R:R:Q191 1003.92NoYes088
33R:R:D295 R:R:E318 99.94555.2NoNo086
34R:R:A299 R:R:E318 93.85014.53NoNo046
35R:R:A299 R:R:Y468 93.34034NoYes044
36R:R:Y458 R:R:Y468 88.568213.9YesYes854
37R:R:E312 R:R:Y458 88.27353.37YesYes855
38R:R:E312 R:R:W487 88.194713.08YesYes857
39R:R:T290 R:R:W487 87.8353.64NoYes877
40R:R:T290 R:R:V265 87.85143.17NoYes078
41R:R:V207 R:R:V265 87.23143.21NoYes088
42R:R:I233 R:R:V207 86.95623.07NoNo068
43R:R:I233 R:R:T205 86.85693.04NoNo067
44R:R:C518 R:R:T205 86.70611.69NoNo1297
45R:R:F345 R:R:P336 10.00467.22YesYes446
46R:R:F345 R:R:W349 11.55416.01YesYes448
47R:R:C518 R:R:C519 86.66893.64NoNo1299
48R:R:C500 R:R:C519 86.2537.28NoNo1299
49R:R:C500 R:R:E502 86.29161.52NoNo094
50R:R:E502 R:R:P503 86.0391.57NoNo045
51R:R:E508 R:R:P503 85.91244.72NoNo065
52R:R:E508 R:R:P524 84.441612.58NoNo063
53R:R:I523 R:R:P524 84.3775.08NoNo043
54R:R:I523 R:R:V512 84.24773.07NoNo042
55R:R:K510 R:R:V512 84.18293.04NoNo072
56R:R:C537 R:R:K510 84.05339.7NoNo097
57R:R:C537 R:R:E529 83.899110.64NoYes1898
58R:R:E529 R:R:Y528 83.769117.96YesYes1888
59R:R:L542 R:R:Y528 83.59812.89NoYes048
60R:R:G543 R:R:L542 83.53283.42NoNo054
61R:R:E712 R:R:G543 83.46751.64NoNo045
62R:R:E712 R:R:R713 83.40218.14NoNo043
63R:R:E708 R:R:R713 83.336711.63NoNo073
64R:R:E708 R:R:V716 83.27125.7NoYes075
65R:R:V716 R:R:Y787 80.36116.31YesYes655
66R:R:R724 R:R:Y787 79.69543.09YesYes685
67R:R:F623 R:R:R724 78.93067.48YesYes088
68R:R:F623 R:R:M619 78.76326.22YesNo087
69R:R:L639 R:R:M619 78.693915.55YesNo087
70R:R:F643 R:R:L639 78.371918.27YesYes3388
71R:R:F643 R:R:W773 77.29795.01YesYes089
72R:R:N735 R:R:W773 76.804310.17NoYes079
73R:R:I739 R:R:N735 76.73372.83NoNo087
74R:R:C742 R:R:I739 76.30834.91NoNo098
75R:R:C742 R:R:Y647 76.23735.38NoYes096
76R:R:L686 R:R:Y647 38.04754.69NoYes2056
77R:R:L686 R:R:Y734 37.96558.21NoNo2058
78R:R:Q690 R:R:Y734 75.75666.76NoNo098
79R:R:Q690 R:R:V694 74.53314.3NoNo096
80R:R:L637 R:R:V694 74.18317.45YesNo046
81R:R:L637 R:R:T641 73.12162.95YesNo3446
82R:R:S644 R:R:T641 72.95653.2NoNo086
83R:R:I687 R:R:S644 72.7814.64NoNo078
84R:R:I687 R:R:S648 72.60556.19NoNo079
85R:R:C683 R:R:S648 71.72725.16NoNo079
86R:R:C683 R:R:T652 71.55145.07NoYes077
87R:R:L605 R:R:T652 14.36534.42YesYes087
88R:R:K653 R:R:L605 13.215315.51YesYes098
89R:R:L738 R:R:Y647 38.047530.48NoYes2096
90R:R:L738 R:R:Y734 37.96558.21NoNo2098
91R:R:N655 R:R:T652 56.5537.31NoYes3267
92R:R:N655 R:R:Y745 56.3993.49NoYes067
93R:R:Y745 S:S:T758 54.76253.75YesNo079
94S:S:A755 S:S:T758 54.58191.68NoNo099
95S:S:A755 S:S:T663 54.40125.03NoNo098
96S:S:L660 S:S:T663 45.5722.95NoNo088
97S:S:L660 S:S:T752 45.02312.95NoYes089
98S:S:L178 S:S:S175 22.72683YesNo087
99S:S:S151 S:S:S175 44.98636.52NoNo097
100S:S:I155 S:S:K177 22.62414.36NoNo054
101S:S:K177 S:S:S175 22.44224.59NoNo047
102S:S:D280 S:S:R277 31.68367.15YesNo144
103S:S:D280 S:S:M276 21.7564.16YesYes144
104S:S:T752 S:S:Y656 43.38068.74YesYes597
105S:S:W782 S:S:Y656 41.39513.86YesYes597
106S:S:F785 S:S:W782 26.20654.01YesYes099
107S:S:F785 S:S:M803 24.51513.73YesYes098
108S:S:F632 S:S:M803 19.93324.98YesYes588
109S:S:F632 S:S:R644 14.928811.76YesYes088
110S:S:C641 S:S:R644 13.96874.18NoYes098
111S:S:C641 S:S:C730 10.8667.28NoNo1699
112S:S:C730 S:S:P712 10.68553.77NoYes1698
113S:S:F652 S:S:W782 12.81775.01YesYes589
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:R64 9.96 1 Yes Yes 0 5 0 1
M:M:?1 S:S:R68 3.32 1 Yes Yes 0 4 0 1
M:M:?1 S:S:S149 3.08 1 Yes Yes 0 5 0 1
M:M:?1 S:S:S151 11.28 1 Yes No 0 9 0 1
M:M:?1 S:S:A172 3.23 1 Yes Yes 0 5 0 1
M:M:?1 S:S:T174 14.09 1 Yes No 0 8 0 1
M:M:?1 S:S:D194 4.63 1 Yes Yes 0 8 0 1
M:M:?1 S:S:Y222 24.02 1 Yes Yes 0 7 0 1
M:M:?1 S:S:R277 7.47 1 Yes No 0 4 0 1
M:M:?1 S:S:K389 7.7 1 Yes Yes 0 4 0 1
S:S:P46 S:S:S149 7.13 1 Yes Yes 6 5 2 1
S:S:P46 S:S:Y150 4.17 1 Yes Yes 6 4 2 2
S:S:N61 S:S:R64 7.23 0 No Yes 4 5 2 1
S:S:R64 S:S:R68 9.6 1 Yes Yes 5 4 1 1
S:S:R64 S:S:Y150 5.14 1 Yes Yes 5 4 1 2
S:S:R68 S:S:S149 5.27 1 Yes Yes 4 5 1 1
S:S:R68 S:S:Y171 7.2 1 Yes Yes 4 6 1 2
S:S:A172 S:S:R68 4.15 1 Yes Yes 5 4 1 1
S:S:E387 S:S:R68 4.65 0 Yes Yes 5 4 2 1
S:S:K389 S:S:R68 7.43 1 Yes Yes 4 4 1 1
S:S:R68 S:S:V393 3.92 1 Yes No 4 6 1 2
S:S:S149 S:S:Y150 3.82 1 Yes Yes 5 4 1 2
S:S:S149 S:S:Y171 5.09 1 Yes Yes 5 6 1 2
S:S:A172 S:S:S149 3.42 1 Yes Yes 5 5 1 1
S:S:S151 S:S:S175 6.52 0 No No 9 7 1 2
S:S:V393 S:S:Y171 7.57 1 No Yes 6 6 2 2
S:S:A172 S:S:K389 4.82 1 Yes Yes 5 4 1 1
S:S:T174 S:S:V191 3.17 1 No No 8 7 1 2
S:S:D194 S:S:T174 13.01 1 Yes No 8 8 1 1
S:S:F392 S:S:V191 9.18 1 Yes No 7 7 2 2
S:S:D194 S:S:Q197 6.53 1 Yes Yes 8 9 1 2
S:S:D194 S:S:Y222 6.9 1 Yes Yes 8 7 1 1
S:S:Q197 S:S:Y222 4.51 1 Yes Yes 9 7 2 1
S:S:F275 S:S:Q197 8.2 1 Yes Yes 8 9 2 2
S:S:Q197 S:S:S300 4.33 1 Yes No 9 8 2 2
S:S:G223 S:S:Y222 4.35 1 No Yes 7 7 2 1
S:S:F275 S:S:Y222 27.85 1 Yes Yes 8 7 2 1
S:S:S300 S:S:Y222 3.82 1 No Yes 8 7 2 1
S:S:F275 S:S:G223 3.01 1 Yes No 8 7 2 2
S:S:F275 S:S:S300 9.25 1 Yes No 8 8 2 2
S:S:D279 S:S:R277 9.53 1 No No 1 4 2 1
S:S:D280 S:S:R277 7.15 1 Yes No 4 4 2 1
S:S:D279 S:S:D280 9.31 1 No Yes 1 4 2 2
S:S:F392 S:S:K389 6.2 1 Yes Yes 7 4 2 1
M:M:?1 S:S:G302 2.34 1 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R57 9.13 2 Yes Yes 0 4 0 1
L:L:?1 R:R:R61 4.15 2 Yes Yes 0 4 0 1
L:L:?1 R:R:S143 3.08 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y144 4.8 2 Yes Yes 0 3 0 1
L:L:?1 R:R:S145 11.28 2 Yes No 0 8 0 1
L:L:?1 R:R:A166 3.23 2 Yes Yes 0 5 0 1
L:L:?1 R:R:T168 11.07 2 Yes No 0 7 0 1
L:L:?1 R:R:S169 5.13 2 Yes No 0 7 0 1
L:L:?1 R:R:D188 3.71 2 Yes Yes 0 8 0 1
L:L:?1 R:R:D215 8.34 2 Yes No 0 5 0 1
L:L:?1 R:R:Y216 29.62 2 Yes Yes 0 7 0 1
L:L:?1 R:R:R271 3.32 2 Yes Yes 0 5 0 1
L:L:?1 R:R:K377 6.74 2 Yes Yes 0 3 0 1
R:R:P39 R:R:S143 7.13 2 No Yes 5 4 2 1
R:R:P39 R:R:Y144 8.34 2 No Yes 5 3 2 1
R:R:N54 R:R:R57 4.82 0 No Yes 4 4 2 1
R:R:R57 R:R:R61 10.66 2 Yes Yes 4 4 1 1
R:R:R57 R:R:Y144 4.12 2 Yes Yes 4 3 1 1
R:R:E375 R:R:R57 3.49 2 Yes Yes 5 4 2 1
R:R:R61 R:R:S143 3.95 2 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 7.2 2 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 2 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 2 Yes Yes 5 4 2 1
R:R:K377 R:R:R61 4.95 2 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 2 Yes No 4 7 1 2
R:R:S93 R:R:Y144 6.36 0 No Yes 1 3 2 1
R:R:S143 R:R:Y144 6.36 2 Yes Yes 4 3 1 1
R:R:S143 R:R:Y165 5.09 2 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 2 Yes Yes 5 4 1 1
R:R:D146 R:R:Y144 3.45 0 No Yes 5 3 2 1
R:R:S145 R:R:S169 6.52 2 No No 8 7 1 1
R:R:V381 R:R:Y165 7.57 2 No Yes 7 8 2 2
R:R:A166 R:R:K377 4.82 2 Yes Yes 5 3 1 1
R:R:T168 R:R:V185 3.17 2 No No 7 7 1 2
R:R:D188 R:R:T168 10.12 2 Yes No 8 7 1 1
R:R:D215 R:R:K171 4.15 0 No No 5 3 1 2
R:R:F380 R:R:V185 9.18 2 Yes No 6 7 2 2
R:R:D188 R:R:Q191 6.53 2 Yes Yes 8 8 1 2
R:R:D188 R:R:Y216 6.9 2 Yes Yes 8 7 1 1
R:R:Q191 R:R:Y216 5.64 2 Yes Yes 8 7 2 1
R:R:Q191 R:R:S294 7.22 2 Yes Yes 8 8 2 2
R:R:S294 R:R:Y216 7.63 2 Yes Yes 8 7 2 1
R:R:G296 R:R:Y216 4.35 0 No Yes 5 7 2 1
R:R:R243 R:R:R271 20.26 0 No Yes 2 5 2 1
R:R:E273 R:R:R271 15.12 2 No Yes 1 5 2 1
R:R:D274 R:R:R271 16.68 2 Yes Yes 4 5 2 1
R:R:D274 R:R:E273 6.5 2 Yes No 4 1 2 2
R:R:F380 R:R:K377 4.96 2 Yes Yes 6 3 2 1
R:R:V147 R:R:Y144 2.52 0 No Yes 4 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

PDB Summary
PDB 8JCX
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu2; mGlu3
Species Homo Sapiens
Ligand LY341495
Other Ligand(s) -
Protein Partners -
PDB Resolution 3
Date 2023-06-21
D.O.I. 10.1038/s41422-023-00830-2
Net Summary
Imin 2.77
Number of Linked Nodes 1428
Number of Links 1778
Number of Hubs 314
Number of Links mediated by Hubs 1100
Number of Communities 42
Number of Nodes involved in Communities 461
Number of Links involved in Communities 682
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 5397695
Length Of Smallest Path 3
Average Path Length 56.4636
Length of Longest Path 117
Minimum Path Strength 1.21
Average Path Strength 6.37048
Maximum Path Strength 25.935
Minimum Path Correlation 0.7
Average Path Correlation 0.998389
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.38889
Average % Of Corr. Nodes 51.3898
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.0454
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • isomerase activity   • catalytic activity, acting on a protein   • peptidyl-prolyl cis-trans isomerase activity   • catalytic activity   • cis-trans isomerase activity   • RNA polymerase II CTD heptapeptide repeat modifying activity   • RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity   • RNA polymerase II CTD heptapeptide repeat P6 isomerase activity   • transforming growth factor beta receptor binding   • signaling receptor binding   • type I transforming growth factor beta receptor binding   • cytokine receptor binding   • FK506 binding   • amide binding   • macrolide binding   • activin receptor binding   • receptor serine/threonine kinase binding   • transmembrane receptor protein serine/threonine kinase binding   • RNA polymerase II CTD heptapeptide repeat P3 isomerase activity   • transmembrane transporter binding   • SMAD binding   • I-SMAD binding   • molecular function inhibitor activity   • signaling receptor inhibitor activity   • signaling receptor regulator activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • protein refolding   • primary metabolic process   • protein maturation   • protein folding   • protein metabolic process   • positive regulation of canonical NF-kappaB signal transduction   • canonical NF-kappaB signal transduction   • regulation of canonical NF-kappaB signal transduction   • activin receptor signaling pathway   • cell surface receptor protein serine/threonine kinase signaling pathway   • regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • negative regulation of activin receptor signaling pathway   • enzyme-linked receptor protein signaling pathway   • negative regulation of response to stimulus   • negative regulation of signal transduction   • transforming growth factor beta receptor superfamily signaling pathway   • regulation of activin receptor signaling pathway   • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • cellular component organization   • cellular component organization or biogenesis   • supramolecular fiber organization   • amyloid fibril formation   • regulation of calcium ion transmembrane transporter activity   • regulation of calcium ion transport   • intracellular calcium ion homeostasis   • calcium ion transport   • monoatomic cation homeostasis   • monoatomic cation transport   • intracellular monoatomic ion homeostasis   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of cation channel activity   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • cellular localization   • inorganic ion homeostasis   • monoatomic ion transmembrane transport   • regulation of transmembrane transporter activity   • calcium ion homeostasis   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • maintenance of location in cell   • regulation of transporter activity   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • monoatomic ion transport   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • regulation of monoatomic ion transmembrane transporter activity   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • regulation of ryanodine-sensitive calcium-release channel activity   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • amyloid precursor protein catabolic process   • regulation of protein metabolic process   • regulation of amyloid precursor protein catabolic process   • regulation of macromolecule metabolic process   • regulation of primary metabolic process   • amyloid precursor protein metabolic process   • regulation of metabolic process   • immune response   • immune system process   • regulation of immune response   • regulation of immune system process   • developmental process   • heart development   • cardiac chamber morphogenesis   • heart trabecula formation   • animal organ development   • heart morphogenesis   • circulatory system development   • anatomical structure morphogenesis   • multicellular organism development   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • cardiac chamber development   • animal organ morphogenesis   • heart trabecula morphogenesis   • trabecula formation   • trabecula morphogenesis   • system development   • T cell activation   • cell activation   • lymphocyte activation   • leukocyte activation   • negative regulation of transforming growth factor beta receptor signaling pathway   • cellular response to growth factor stimulus   • cellular response to transforming growth factor beta stimulus   • regulation of transforming growth factor beta receptor signaling pathway   • cellular response to endogenous stimulus   • regulation of cellular response to transforming growth factor beta stimulus   • response to endogenous stimulus   • regulation of cellular response to growth factor stimulus   • response to transforming growth factor beta   • transforming growth factor beta receptor signaling pathway   • response to growth factor   • protein localization   • regulation of protein localization   • regulation of cellular localization   • cellular macromolecule localization   • macromolecule localization   • 'de novo' protein folding   • system process   • regulation of system process   • sarcoplasmic reticulum calcium ion transport   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • multicellular organismal movement   • regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion   • regulation of skeletal muscle contraction by calcium ion signaling   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • skeletal muscle contraction   • muscle contraction   • regulation of striated muscle contraction   • regulation of muscle contraction   • calcium-mediated signaling   • striated muscle contraction   • musculoskeletal movement   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • nervous system process   • neuromuscular process   • muscle system process   • regulation of muscle system process   • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • ventricular cardiac muscle tissue morphogenesis   • striated muscle tissue development   • muscle structure development   • ventricular cardiac muscle tissue development   • muscle tissue development   • muscle organ development   • cardiac muscle tissue development   • tissue development   • muscle tissue morphogenesis   • tissue morphogenesis   • cardiac ventricle morphogenesis   • cardiac muscle tissue morphogenesis   • cardiac ventricle development   • muscle organ morphogenesis   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon   • membrane-bounded organelle   • intracellular anatomical structure   • organelle subcompartment   • intracellular membrane-bounded organelle   • endomembrane system   • sarcoplasm   • intracellular organelle   • endoplasmic reticulum subcompartment   • terminal cisterna   • organelle   • endoplasmic reticulum   • sarcoplasmic reticulum   • cytoplasm   • intracellular membraneless organelle   • Z disc   • sarcomere   • I band   • membraneless organelle   • contractile muscle fiber   • supramolecular fiber   • myofibril   • supramolecular polymer   • supramolecular complex   • bounding membrane of organelle   • nuclear outer membrane-endoplasmic reticulum membrane network   • sarcoplasmic reticulum membrane   • organelle membrane   • endoplasmic reticulum membrane   • cytoplasmic side of membrane   • side of membrane   • cytosol   • protein-containing complex   • membrane protein complex   • ryanodine receptor complex   • transporter complex   • endoplasmic reticulum protein-containing complex   • plasma membrane protein complex   • voltage-gated calcium channel complex   • cation channel complex   • transmembrane transporter complex   • calcium channel complex   • monoatomic ion channel complex   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • adenyl ribonucleotide binding   • nucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • adenyl nucleotide binding   • ATP binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein serine/threonine kinase activity   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • catalytic activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • protein-containing complex binding   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • biological regulation   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stimulus   • cellular response to stress   • response to stimulus   • response to stress   • cellular process   • trans-synaptic signaling   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • regulation of cell communication   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • cellular component organization   • regulation of cellular component organization   • cellular component organization or biogenesis   • negative regulation of catabolic process   • catabolic process   • negative regulation of metabolic process   • autophagy   • negative regulation of biological process   • regulation of catabolic process   • regulation of autophagy   • negative regulation of autophagy   • negative regulation of cellular process   • process utilizing autophagic mechanism   • regulation of metabolic process   • regulation of cellular response to stress   • regulation of response to stimulus   • regulation of response to stress   • regulation of protein metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • regulation of primary metabolic process   • protein metabolic process   • neuron spine   • dendritic spine   • postsynaptic density   • neuron to neuron synapse   • postsynaptic specialization   • asymmetric synapse   • TORC1 complex   • TOR complex   • intracellular protein-containing complex
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1002 H:H:?1101
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeZ99
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeZ99
Name2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine
Synonyms(1S,2S)-2-[(2S)-2-amino-1-hydroxy-1-oxo-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid
Identifier
FormulaC20 H19 N O5
Molecular Weight353.369
SMILES
PubChem9819927
Formal Charge0
Total Atoms45
Total Chiral Atoms3
Total Bonds48
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>8JCX_Chain_R
KVLTLEGDL VLGGLFPVH QKGGPAEDC GPVNEHRGI QRLEAMLFA 
LDRINRDPH LLPGVRLGA HILDSCSKD THALEQALD FVRASLSAP 
TAITGVIGG SYSDVSIQV ANLLRLFQI PQISYASTS AKLSDKSRY 
DYFARTVPP DFFQAKAMA EILRFFNWT YVSTVASEG DYGETGIEA 
FELEARARN ICVATSEKV GRAMSRAAF EGVVRALLQ KPSARVAVL 
FTRSEDARE LLAASQRLN ASFTWVASD GWGALESVV AGSEGAAEG 
AITIELASY PISDFASYF QSLDPWNNS RNPWFREFW EQRFRCSFR 
QRDCAAHSL RAVPFEQES KIMFVVNAV YAMAHALHN MHRALCPNT 
TRLCDAMRP VNGRRLYKD FVLNVKFDA PFRPADTHN EVRFDRFGD 
GIGRYNIFT YLRAGSGRY RYQKVGYWA EGLTLDTSL IPWASPSAG 
PLPASRCSE PCLQNEVKS VQPGEVCCW LCIPCQPYE YRLDEFTCA 
DCGLGYWPN ASLTGCFEL PQEYIRWGD AWAVGPVTI ACLGALATL 
FVLGVFVRH NATPVVKAS GRELCYILL GGVFLCYCM TFIFIAKPS 
TAVCTLRRL GLGTAFSVC YSALLTKTN RIARISPAS QVAICLALI 
SGQLLIVVA WLVVEAPGT GKETAPERR EVVTLRCNH RDASMLGSL 
AYNVLLIAL CTLYAFKTR KCPENFNEA KFIGFTMYT TCIIWLAFL 
PIFYVTSSD YRVQTTTMC VSVSLSGSV VLGCLFAPK LHIIL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14832
Sequence
>8JCX_Chain_S
RREIKIEGD LVLGGLFPI NEKGTGTEE CGRINEDRG IQRLEAMLF 
AIDEINKDD YLLPGVKLG VHILDTCSR DTYALEQSL EFVRASLNI 
PLLIAGVIG GSYSSVSIQ VANLLRLFQ IPQISYAST SAKLSDKSR 
YDYFARTVP PDFYQAKAM AEILRFFNW TYVSTVASE GDYGETGIE 
AFEQEARLR NICIATAEK VGRSNIRKS YDSVIRELL QKPNARVVV 
LFMRSDDSR ELIAAASRA NASFTWVAS DGWGAQESI IKGSEHVAY 
GAITLELAS QPVRQFDRY FQSLNPYNN HRNPWFRDF WEQKFQCSL 
QNKRNHRRV CDKHLAIDS SNYEQESKI MFVVNAVYA MAHALHKMQ 
RTLCPNTTK LCDAMKILD GKKLYKDYL LKINFTAPF NPNKDADSI 
VKFDTFGDG MGRYNVFNF QNVGGKYSY LKVGHWAET LSLDVNSIH 
WSRNSVPTS QCSDPCAPN EMKNMQPGD VCCWICIPC EPYEYLADE 
FTCMDCGSG QWPTADLTG CYDLPEDYI RWEDAWAIG PVTIACLGF 
MCTCMVVTV FIKHNNTEL CYILLFGVG LSYCMTFFF IAKPSPVIC 
ALRRLGLGS SFAICYSAL LTKTNCSPS SQVFICLGL ILVQIVMVS 
VWLILEAPG TRRYTLAEK RETVILKCN VKDSSMLIS LTYDVILVI 
LCTVYAFKT RKCPENFNE AKFIGFTMY TTCIIWLAF LPIFYVTSS 
DYRVQTTTM CISVSLSGF VVLGCLFAP KVHI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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