Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L26 4.215615
2R:R:L28 3.7825414
3R:R:L34 3.8875407
4R:R:F38 5.274518
5R:R:H41 5.45667618
6R:R:G44 1.97254274
7R:R:R57 7.255404
8R:R:R61 5.94625814
9R:R:L62 3.74333615
10R:R:E63 4.1575418
11R:R:M65 4.175409
12R:R:L66 3.595415
13R:R:F67 6.816517
14R:R:R71 7.3025417
15R:R:L78 5.944117
16R:R:L84 3.8225409
17R:R:H87 5.152514
18R:R:I88 5.395417
19R:R:L89 8.134515
20R:R:D90 8.31519
21R:R:C92 5.762518
22R:R:K94 6.0875413
23R:R:H97 5.654513
24R:R:L99 3.655485
25R:R:F105 7.105416
26R:R:C121 3.8054128
27R:R:D123 7.44754125
28R:R:I136 4.305406
29R:R:T137 3.774264
30R:R:S143 5.0475414
31R:R:Y144 8.016513
32R:R:L154 3.272505
33R:R:L155 3.53416
34R:R:R156 4.095405
35R:R:F158 6.088506
36R:R:I160 3.8925416
37R:R:P161 2.5575419
38R:R:Q162 5.844518
39R:R:I163 4.515407
40R:R:Y165 6.30857718
41R:R:S167 5.4925418
42R:R:K171 4.2025413
43R:R:L172 5.70833617
44R:R:R177 6.094515
45R:R:Y178 6.18571716
46R:R:Y180 7.124516
47R:R:F181 6.25286719
48R:R:R183 6.632519
49R:R:P186 4.104518
50R:R:P187 6.64667617
51R:R:F189 5.212513
52R:R:F190 4.54571715
53R:R:Q191 10.4125418
54R:R:M195 4.255417
55R:R:F202 8.7475418
56R:R:W204 7.112519
57R:R:Y206 5.154509
58R:R:Y216 6.185407
59R:R:I221 4.9525405
60R:R:F224 3.84417
61R:R:R231 4.7175404
62R:R:V265 4.5275408
63R:R:V267 4.5525416
64R:R:F269 5.9475407
65R:R:Q283 4.08403
66R:R:W291 6.584507
67R:R:D295 8.1875418
68R:R:W297 4.3658176
69R:R:V303 2.48404
70R:R:L319 3.502514
71R:R:D326 3.49414
72R:R:F327 5.6125418
73R:R:F331 6.552516
74R:R:P336 3.968516
75R:R:N342 5.918517
76R:R:P343 5.065412
77R:R:W344 5.0151014
78R:R:F345 5.43404
79R:R:F348 6.838516
80R:R:W349 5.065618
81R:R:F353 8.58417
82R:R:C355 4.3775418
83R:R:F357 8.036513
84R:R:K377 4.612513
85R:R:I378 4.758517
86R:R:F380 8.366516
87R:R:Y386 5.31714716
88R:R:L392 4.2354268
89R:R:C400 4.66403
90R:R:L406 4.5954252
91R:R:C407 3.4407
92R:R:Y419 5.206515
93R:R:F422 5.494334
94R:R:F428 7.594508
95R:R:P431 4.9175417
96R:R:F432 5.154514
97R:R:N439 5.6754315
98R:R:R442 6.8975403
99R:R:F446 5.135417
100R:R:D448 6.59833617
101R:R:R452 6.774314
102R:R:Y453 4.6325818
103R:R:F456 4.095405
104R:R:Y468 4.5354174
105R:R:W474 5.67333616
106R:R:L478 4.026516
107R:R:I485 4.982517
108R:R:P486 4.9175413
109R:R:W487 5.88143717
110R:R:C500 4.16754159
111R:R:P514 2.50754155
112R:R:E516 4.48754154
113R:R:C525 7.2425479
114R:R:Y528 6.55578
115R:R:E529 13.272578
116R:R:Y530 5.44167667
117R:R:R531 5.182567
118R:R:C540 4.484569
119R:R:P546 6.488568
120R:R:C553 5.8525469
121R:R:L556 5.3575468
122R:R:W563 7.7405
123R:R:T582 6.0285197
124R:R:V588 6.446536
125R:R:F589 9.7525439
126R:R:H592 10.148534
127R:R:T595 6.9575439
128R:R:V598 5.235439
129R:R:R603 4.3775409
130R:R:L605 6.43754348
131R:R:L610 4.9675439
132R:R:V613 8.9754198
133R:R:Y617 7.702867198
134R:R:T633 3.25754135
135R:R:R636 8.0385138
136R:R:Y647 10.7154146
137R:R:L651 4.52754209
138R:R:Y655 8.73754206
139R:R:R656 4.8354348
140R:R:Q679 5.75508
141R:R:E701 2.5425406
142R:R:K707 4.758502
143R:R:L719 7.29754187
144R:R:R720 4.825406
145R:R:H723 6.31254135
146R:R:M728 2.2025407
147R:R:V736 5.844145
148R:R:T743 1.9025408
149R:R:M766 2.9725409
150R:R:W773 8.995149
151R:R:L777 7.2754147
152R:R:R788 9.0385185
153R:R:Q790 9.172507
154R:R:M794 5.7975409
155R:R:L806 7.8556198
156R:R:F810 17.065439
157R:R:K813 8.00667639
158R:R:Q820 5.725406
159S:S:L32 3.6075495
160S:S:L34 4.245407
161S:S:F38 5.688518
162S:S:H41 5.63167618
163S:S:R57 7.51404
164S:S:R61 6.66333614
165S:S:L62 4.23415
166S:S:E63 8.93418
167S:S:M65 4.9025409
168S:S:F67 5.974507
169S:S:L78 4.74667617
170S:S:H87 5.18333614
171S:S:L89 10.05515
172S:S:D90 7.262519
173S:S:C92 5.114518
174S:S:K94 5.9975413
175S:S:H97 4.656513
176S:S:L99 4.2625415
177S:S:D123 7.44754125
178S:S:I136 2.905406
179S:S:T137 3.9425404
180S:S:I140 4.785407
181S:S:S143 5.0475414
182S:S:Y144 7.99513
183S:S:N153 5.9475415
184S:S:L154 3.3975405
185S:S:L157 4.292585
186S:S:F158 5.465686
187S:S:P161 2.702509
188S:S:Y165 6.78429718
189S:S:L172 5.99286717
190S:S:R177 5.705615
191S:S:Y178 6.975616
192S:S:Y180 7.7985166
193S:S:F181 6.12571719
194S:S:R183 5.865419
195S:S:P186 4.104518
196S:S:P187 5.88333617
197S:S:F189 6.09413
198S:S:F190 4.28571715
199S:S:Q191 10.07418
200S:S:E197 3.01416
201S:S:F202 9.7675418
202S:S:W204 7.112519
203S:S:Y206 4.886509
204S:S:T209 2.6375416
205S:S:Y216 3.89143717
206S:S:F224 3.01333617
207S:S:R231 6.78514
208S:S:V241 2.9375406
209S:S:V265 4.5275408
210S:S:F269 4.065617
211S:S:F289 6.3475406
212S:S:W291 6.2056407
213S:S:S294 7.305418
214S:S:D295 7.6125418
215S:S:W297 4.74258106
216S:S:V303 3.33504
217S:S:L319 3.6325414
218S:S:F327 5.92754378
219S:S:F331 6.572516
220S:S:L334 5.3025415
221S:S:P336 5.7516
222S:S:W337 2.9575413
223S:S:N342 6.0825417
224S:S:P343 5.405412
225S:S:W344 5.85889914
226S:S:F345 5.23514
227S:S:R346 5.0225413
228S:S:F348 6.856516
229S:S:W349 5.45618
230S:S:F353 10.18417
231S:S:F357 5.1613
232S:S:K377 4.612513
233S:S:M379 7.7275418
234S:S:F380 7.37516
235S:S:N383 4.962518
236S:S:Y386 4.37571716
237S:S:C400 4.66403
238S:S:L406 3.784592
239S:S:C407 3.4407
240S:S:Y419 5.488336165
241S:S:F422 7.288504
242S:S:F428 9.195408
243S:S:P431 5.325417
244S:S:F432 5.554514
245S:S:R433 4.76403
246S:S:N439 4.9175405
247S:S:R442 8.32754413
248S:S:F446 6.0525417
249S:S:D448 5.90667617
250S:S:Y453 4.6625818
251S:S:F456 5.8454105
252S:S:Y468 3.99254104
253S:S:K470 6.4875405
254S:S:V471 4.2525417
255S:S:W474 4.76286716
256S:S:L478 4.312516
257S:S:I485 4.806517
258S:S:W487 5.32714717
259S:S:C500 3.7375429
260S:S:K510 4.29427
261S:S:P514 2.5075425
262S:S:E516 4.4875424
263S:S:C519 5.06429
264S:S:E529 11.474528
265S:S:Y530 14.1217647
266S:S:R531 10.88547
267S:S:C540 5.2675449
268S:S:P546 6.756548
269S:S:C553 5.5175449
270S:S:L556 5.3575448
271S:S:W563 7.965405
272S:S:T582 6.0285227
273S:S:V588 6.446556
274S:S:F589 10.3725459
275S:S:H592 10.422554
276S:S:T595 6.905459
277S:S:V598 4.4625459
278S:S:R603 4.3775409
279S:S:L605 6.9354238
280S:S:L610 4.316559
281S:S:V613 8.9754228
282S:S:Y617 7.702867228
283S:S:K626 2.244434
284S:S:R636 7.374508
285S:S:Y647 11.3654456
286S:S:L651 4.52754249
287S:S:Y655 8.40254246
288S:S:R656 3.95238
289S:S:Q679 5.75508
290S:S:H723 6.1154445
291S:S:V736 6.1554455
292S:S:T743 1.9025408
293S:S:E758 6.135409
294S:S:W773 5.76409
295S:S:R788 9.4685215
296S:S:Q790 11.1275407
297S:S:M794 3.90254479
298S:S:L806 7.8556228
299S:S:F810 17.065459
300S:S:K813 8.16833659
301S:S:Q820 5.725406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G36 R:R:I88 13.27783.53NoYes087
2R:R:G35 R:R:G36 22.62612.11NoNo098
3R:R:L406 R:R:R411 22.67988.5YesNo021
4R:R:P412 R:R:R411 23.67111.44NoNo041
5R:R:P412 R:R:R112 24.66251.44NoNo042
6R:R:A135 R:R:R112 26.6454.15NoNo042
7R:R:A135 R:R:S109 27.63721.71NoNo044
8R:R:I136 R:R:S109 28.62946.19YesNo064
9R:R:G35 R:R:V139 23.60853.68NoNo097
10R:R:K377 R:R:R61 10.37558.66YesYes134
11R:R:L154 S:S:L157 12.33232.77YesYes055
12R:R:L154 R:R:L155 35.46632.77YesYes056
13R:R:L155 R:R:Q162 14.78292.66YesYes168
14R:R:Q162 R:R:V139 23.71792.87YesNo087
15R:R:L154 S:S:F158 12.46082.44YesYes056
16R:R:F158 R:R:L154 12.20963.65YesYes065
17R:R:I136 R:R:I160 34.93692.94YesYes066
18R:R:A152 R:R:Y178 20.8642.67NoYes176
19R:R:A152 R:R:Q162 20.43994.55NoYes178
20R:R:N153 R:R:R156 11.03992.41NoYes055
21R:R:D179 R:R:R156 12.48437.15NoYes075
22R:R:D179 R:R:Y180 12.12935.75NoYes076
23R:R:Y180 R:R:Y419 10.80938.94YesYes165
24R:R:R156 S:S:N153 15.56773.62YesYes055
25R:R:R177 R:R:Y178 58.51784.12YesYes156
26R:R:R177 S:S:R177 58.5657.46YesYes155
27R:R:K377 R:R:L319 10.91052.82YesYes134
28R:R:P186 R:R:P187 10.47311.95YesYes187
29R:R:L478 R:R:W474 14.82976.83YesYes166
30R:R:F201 R:R:L478 14.77243.65NoYes156
31R:R:F201 R:R:F202 14.64046.43NoYes158
32R:R:F202 R:R:W487 12.3126.01YesYes187
33R:R:P486 R:R:W487 11.73112.7YesYes137
34R:R:L459 R:R:P486 11.04154.93NoYes063
35R:R:L459 R:R:R467 10.68816.07NoNo062
36R:R:Q469 R:R:R467 10.511612.85NoNo042
37R:R:K470 R:R:Q469 10.37432.71NoNo054
38R:R:F456 R:R:K470 10.19632.48YesNo055
39R:R:L406 R:R:M410 19.71172.83YesNo022
40R:R:L399 R:R:M410 18.72412.83NoNo032
41R:R:C400 R:R:L399 11.81184.76YesNo033
42S:S:R177 S:S:Y178 66.69437.2YesYes156
43S:S:L172 S:S:Y178 76.12210.55YesYes176
44S:S:L172 S:S:R183 82.84513.64YesYes179
45S:S:P187 S:S:R183 84.49058.65YesYes179
46S:S:F190 S:S:P187 69.88882.89YesYes157
47S:S:F190 S:S:W474 76.80462YesYes156
48S:S:E197 S:S:W474 94.68874.36YesYes166
49S:S:E197 S:S:R231 1002.33YesYes164
50S:S:R200 S:S:R231 99.560113.86NoYes144
51S:S:I233 S:S:R200 99.61242.51NoNo064
52S:S:I233 S:S:T205 99.48213.04NoNo067
53S:S:R499 S:S:T205 99.41679.06NoNo057
54S:S:C500 S:S:R499 99.21971.39YesNo095
55S:S:C500 S:S:S501 97.00941.72YesNo298
56S:S:S501 S:S:W520 98.559619.77NoNo087
57S:S:S511 S:S:W520 98.34213.71NoNo057
58S:S:F535 S:S:S511 98.26931.32NoNo025
59S:S:D533 S:S:F535 98.19642.39NoNo072
60S:S:D533 S:S:E534 98.053.9NoNo076
61S:S:E534 S:S:Q506 97.97661.27NoNo065
62S:S:Q506 S:S:V509 97.90312.87NoNo056
63S:S:R531 S:S:V509 97.82943.92YesNo076
64S:S:P546 S:S:R531 94.89582.88YesYes487
65S:S:P546 S:S:W545 95.074912.16YesNo486
66S:S:L556 S:S:W545 93.69254.56YesNo486
67S:S:L556 S:S:Q558 94.05583.99YesNo084
68S:S:Q558 S:S:V717 93.976411.46NoNo048
69S:S:L719 S:S:V717 93.09327.45NoNo078
70S:S:L719 S:S:R562 93.012117.01NoNo076
71S:S:R562 S:S:R788 81.28124.26NoYes2165
72S:S:R788 S:S:T792 69.83833.88YesNo057
73S:S:C795 S:S:T792 69.73861.69NoNo077
74S:S:C795 S:S:V796 68.84211.71NoNo077
75S:S:L800 S:S:V796 68.54192.98NoNo067
76S:S:L800 S:S:S803 68.44333NoNo066
77S:S:S803 S:S:V804 68.34621.62NoNo067
78S:S:C808 S:S:V804 68.05541.71NoNo067
79S:S:C808 S:S:T765 67.95868.45NoNo069
80S:S:I762 S:S:T765 67.86183.04NoNo099
81S:S:I762 S:S:K653 67.76545.82NoNo099
82S:S:E758 S:S:K653 67.57654.05YesNo099
83S:S:E758 S:S:N755 66.916911.83YesNo097
84S:S:N755 S:S:V597 66.72744.43NoNo077
85S:S:I816 S:S:V597 66.632615.36NoNo077
86S:S:I816 S:S:Q820 66.5385.49NoYes076
87S:S:Q820 S:S:T595 66.2559.92YesYes069
88S:S:K813 S:S:T595 63.44984.5YesYes599
89S:S:F589 S:S:K813 65.637218.61YesYes599
90S:S:F589 S:S:L610 65.24252.44YesYes599
91S:S:G611 S:S:L610 65.32371.71NoYes049
92S:S:G611 S:S:G612 65.10242.11NoNo048
93S:S:G612 S:S:L615 64.6585.13NoNo085
94S:S:C618 S:S:L615 64.54663.17NoNo065
95S:S:C618 S:S:M619 64.4356.48NoNo067
96S:S:G638 S:S:M619 64.21135.24NoNo067
97S:S:G638 S:S:T641 64.09933.64NoNo066
98S:S:L637 S:S:T641 63.76232.95NoNo046
99S:S:L637 S:S:L698 63.64962.77NoNo046
100S:S:L698 S:S:V695 61.25115.96NoNo063
101R:R:V695 S:S:V695 61.13521.6NoNo033
102R:R:L698 R:R:V695 61.025.96NoNo063
103R:R:L698 R:R:R636 59.144914.58NoYes068
104R:R:H723 R:R:R636 56.26256.77YesYes1358
105R:R:H723 R:R:R724 54.92862.26YesNo058
106R:R:R720 R:R:R724 54.80578.53YesNo068
107R:R:L719 R:R:R720 52.62343.64YesYes076
108R:R:R562 R:R:R788 23.74346.4NoYes1865
109R:R:L719 R:R:R562 23.886314.58YesNo1876
110R:R:R788 R:R:Y787 23.743423.66YesNo1855
111R:R:L719 R:R:Y787 23.88633.52YesNo1875
112R:R:M794 R:R:V798 10.29224.56YesNo098
113R:R:M794 R:R:Q790 37.29914.08YesYes097
114R:R:Q790 R:R:T783 38.80785.67YesNo077
115R:R:D786 R:R:T783 39.71134.34NoNo087
116R:R:D786 R:R:V789 40.31297.3NoNo085
117R:R:R788 R:R:V789 40.61356.54YesNo055
118R:R:S601 R:R:V598 12.67423.23NoYes099
119R:R:G602 R:R:S601 13.30183.71NoNo099
120R:R:G602 R:R:R656 13.59674.5NoYes3498
121R:R:Q679 R:R:R656 16.11124.67YesYes088
122R:R:Q679 R:R:Y655 17.674811.27YesYes086
123R:R:L651 R:R:Y655 18.29345.86YesYes2096
124R:R:C742 R:R:L651 20.02546.35NoYes099
125R:R:C742 R:R:I739 20.33093.27NoNo098
126R:R:I739 R:R:Y647 21.552126.59NoYes086
127R:R:V736 R:R:Y647 22.1548.83YesYes1456
128R:R:V736 R:R:W773 24.01083.68YesYes1459
129R:R:F776 R:R:W773 24.913923.05NoYes1499
130R:R:F776 R:R:M794 26.169.95NoYes099
131S:S:L154 S:S:L155 12.59332.77YesNo056
132S:S:K377 S:S:L319 17.312.82YesYes134
133S:S:K377 S:S:R61 15.93618.66YesYes134
134S:S:F38 S:S:L62 11.79264.87YesYes185
135S:S:F345 S:S:N342 10.6026.04YesYes147
136S:S:F380 S:S:L319 11.48246.09YesYes164
137S:S:F380 S:S:M379 10.87287.46YesYes168
138S:S:I149 S:S:N153 11.66622.83NoYes155
139S:S:A223 S:S:F189 12.09471.39NoYes033
140S:S:A192 S:S:A223 11.81561.79NoNo053
141S:S:A192 S:S:F224 11.55731.39NoYes057
142S:S:F224 S:S:V207 11.95612.62YesNo178
143S:S:V207 S:S:V265 11.76836.41NoYes088
144S:S:S498 S:S:V265 14.83874.85NoYes098
145S:S:R264 S:S:S498 12.01196.59NoNo069
146S:S:F289 S:S:R264 11.7542.14YesNo066
147S:S:R562 S:S:Y787 11.64952.06NoNo2165
148S:S:V789 S:S:Y787 11.52342.52NoNo2155
149S:S:D786 S:S:V789 22.98117.3NoNo085
150S:S:D786 S:S:T783 22.38874.34NoNo087
151S:S:Q790 S:S:T783 21.70697.09YesNo077
152S:S:M794 S:S:Q790 20.79752.72YesYes097
153S:S:M794 S:S:V798 19.88694.56YesNo098
154S:S:S801 S:S:V798 19.65911.62NoNo098
155S:S:G802 S:S:S801 19.43133.71NoNo089
156S:S:G802 S:S:Y617 19.2044.35NoYes088
157S:S:R788 S:S:V789 11.75446.54YesNo2155
158S:S:L806 S:S:Y617 14.553114.07YesYes2288
159S:S:L806 S:S:V805 14.18352.98YesNo087
160S:S:T769 S:S:V805 13.80331.59NoNo087
161S:S:M766 S:S:T769 13.57341.51NoNo098
162S:S:M766 S:S:T743 12.65361.51NoYes098
163S:S:L651 S:S:T743 11.9632.95YesYes098
164R:R:I160 R:R:L155 27.57925.71YesYes166
165R:R:N153 S:S:L157 11.82834.12NoYes055
166R:R:P187 R:R:R183 39.22248.65YesYes179
167R:R:F190 R:R:P187 24.35185.78YesYes157
168R:R:F190 R:R:W474 20.53292YesYes156
169S:S:F181 S:S:Q162 12.084810.54YesNo098
170S:S:I149 S:S:L172 11.71515.71NoYes157
171S:S:N153 S:S:Y178 11.738910.47YesYes156
172R:R:L172 R:R:Y178 38.811610.55YesYes176
173R:R:L172 R:R:R183 38.23594.86YesYes179
174S:S:W474 S:S:Y453 21.29023.86YesYes168
175S:S:L319 S:S:Y453 20.13622.34YesYes148
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPA
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu2; mGlu2
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.6
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03641-w
Net Summary
Imin 1.87
Number of Linked Nodes 1469
Number of Links 1819
Number of Hubs 301
Number of Links mediated by Hubs 1098
Number of Communities 47
Number of Nodes involved in Communities 473
Number of Links involved in Communities 715
Path Summary
Number Of Nodes in MetaPath 176
Number Of Links MetaPath 175
Number of Shortest Paths 2611139
Length Of Smallest Path 3
Average Path Length 48.2297
Length of Longest Path 122
Minimum Path Strength 1.185
Average Path Strength 5.46158
Maximum Path Strength 25.345
Minimum Path Correlation 0.7
Average Path Correlation 0.99657
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.40845
Average % Of Corr. Nodes 56.714
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.4583
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7EPA_Chain_R
KVLTLEGDL VLGGLFPVH QKGGPAEDC GPVNEHRGI QRLEAMLFA 
LDRINRDPH LLPGVRLGA HILDSCSKD THALEQALD FVRASLSRG 
ADGSRHICP DGSYATHGD APTAITGVI GGSYSDVSI QVANLLRLF 
QIPQISYAS TSAKLSDKS RYDYFARTV PPDFFQAKA MAEILRFFN 
WTYVSTVAS EGDYGETGI EAFELEARA RNICVATSE KVGRAMSRA 
AFEGVVRAL LQKPSARVA VLFTRSEDA RELLAASQR LNASFTWVA 
SDGWGALES VVAGSEGAA EGAITIELA SYPISDFAS YFQSLDPWN 
NSRNPWFRE FWEQRFRCS FRQRDCAAH SLRAVPFEQ ESKIMFVVN 
AVYAMAHAL HNMHRALCP NTTRLCDAM RPVNGRRLY KDFVLNVKF 
DAPFRPADT HNEVRFDRF GDGIGRYNI FTYLRAGSG RYRYQKVGY 
WAEGLTLDT SLIPWASPS AGPLPASRC SEPCLQNEV KSVQPGEVC 
CWLCIPCQP YEYRLDEFT CADCGLGYW PNASLTGCF ELPQEYIRW 
GDAWAVGPV TIACLGALA TLFVLGVFV RHNATPVVK ASGRELCYI 
LLGGVFLCY CMTFIFIAK PSTAVCTLR RLGLGTAFS VCYSALLTK 
TYRIAISPA SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER 
REVVTLRCN HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE 
AKFIGFTMY TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS 
VVLGCLFAP KLYIILFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7EPA_Chain_S
KVLTLEGDL VLGGLFPVH QKGGPAEDC GPVNEHRGI QRLEAMLFA 
LDRINRDPH LLPGVRLGA HILDSCSKD THALEQALD FVRASLSRG 
ADGSRHICP DGSYATHGD APTAITGVI GGSYSDVSI QVANLLRLF 
QIPQISYAS TSAKLSDKS RYDYFARTV PPDFFQAKA MAEILRFFN 
WTYVSTVAS EGDYGETGI EAFELEARA RNICVATSE KVGRAMSRA 
AFEGVVRAL LQKPSARVA VLFTRSEDA RELLAASQR LNASFTWVA 
SDGWGALES VVAGSEGAA EGAITIELA SYPISDFAS YFQSLDPWN 
NSRNPWFRE FWEQRFRCS FRQRDCAAH SLRAVPFEQ ESKIMFVVN 
AVYAMAHAL HNMHRALCP NTTRLCDAM RPVNGRRLY KDFVLNVKF 
DAPFRPADT HNEVRFDRF GDGIGRYNI FTYLRAGSG RYRYQKVGY 
WAEGLTLDT SLIPWASPS AGPLPASRC SEPCLQNEV KSVQPGEVC 
CWLCIPCQP YEYRLDEFT CADCGLGYW PNASLTGCF ELPQEYIRW 
GDAWAVGPV TIACLGALA TLFVLGVFV RHNATPVVK ASGRELCYI 
LLGGVFLCY CMTFIFIAK PSTAVCTLR RLGLGTAFS VCYSALLTK 
TYRIAISPA SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER 
REVVTLRCN HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE 
AKFIGFTMY TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS 
VVLGCLFAP KLYIILFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E9GCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/&β;1/&γ;23.52021-06-2310.1038/s41586-021-03495-2
7EPACAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPFCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7MTQCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTRCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/&β;1/&γ;23.22021-07-0710.1038/s41586-021-03680-3
8JCUCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateJ9R-3.32023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD2CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/&β;1/&γ;23.32023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/&β;1/&γ;23.62023-06-2110.1038/s41422-023-00830-2
7EPDCAminoacidMetabotropic glutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w




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