Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L26 4.215615
2R:R:L28 3.7825414
3R:R:L34 3.8875407
4R:R:G36 2.7425418
5R:R:F38 5.274518
6R:R:P39 2.814515
7R:R:H41 5.564518
8R:R:V53 5.6575413
9R:R:E55 11.7875415
10R:R:R57 7.255404
11R:R:R61 5.94625814
12R:R:L62 3.74333615
13R:R:E63 4.1575418
14R:R:M65 4.175409
15R:R:L66 3.595415
16R:R:F67 6.816517
17R:R:R71 7.3025417
18R:R:L78 5.60254127
19R:R:L84 3.8225409
20R:R:H87 5.152514
21R:R:I88 5.395417
22R:R:L89 8.134515
23R:R:D90 8.31519
24R:R:S91 3.5575416
25R:R:C92 5.585418
26R:R:H97 7.42413
27R:R:L99 3.6554105
28R:R:F105 7.105416
29R:R:C121 3.97478
30R:R:Y126 4.67714772
31R:R:D131 4.644572
32R:R:I136 4.305406
33R:R:T137 3.38514
34R:R:S143 4.38514
35R:R:Y144 8.016513
36R:R:L154 3.272505
37R:R:L155 3.53416
38R:R:R156 4.095405
39R:R:F158 6.088506
40R:R:I160 3.8925416
41R:R:P161 2.5575419
42R:R:Q162 5.844518
43R:R:I163 4.515407
44R:R:Y165 6.30857718
45R:R:S167 5.4925418
46R:R:K171 4.2025413
47R:R:L172 5.70833617
48R:R:R177 6.094515
49R:R:Y178 6.18571716
50R:R:Y180 7.124516
51R:R:F181 6.25286719
52R:R:R183 6.632519
53R:R:V185 4.8975417
54R:R:P186 3.715618
55R:R:P187 6.64667617
56R:R:D188 5.5354218
57R:R:F189 5.212513
58R:R:F190 4.54571715
59R:R:Q191 10.4125418
60R:R:M195 4.255417
61R:R:F202 8.7475418
62R:R:W204 7.112519
63R:R:Y206 5.154509
64R:R:Y216 5.638507
65R:R:I221 5.295405
66R:R:F224 3.84417
67R:R:R231 5.2275404
68R:R:F250 10.95254263
69R:R:V265 4.5275408
70R:R:V267 4.5525416
71R:R:F269 5.9475407
72R:R:W291 6.584507
73R:R:D295 8.1875418
74R:R:W297 4.3658136
75R:R:V303 2.805404
76R:R:L319 3.502514
77R:R:D326 3.49414
78R:R:F327 5.6125418
79R:R:F331 6.552516
80R:R:P336 3.968516
81R:R:N342 5.918517
82R:R:P343 5.065412
83R:R:W344 5.20889914
84R:R:F345 5.43404
85R:R:F348 9.17516
86R:R:W349 5.065618
87R:R:F353 8.58417
88R:R:C355 4.3775418
89R:R:F357 7.336513
90R:R:K377 4.612513
91R:R:I378 4.758517
92R:R:F380 8.366516
93R:R:Y386 5.31714716
94R:R:L392 4.235418
95R:R:C400 4.66403
96R:R:L406 4.5954242
97R:R:C407 3.4407
98R:R:Y419 5.206515
99R:R:F422 5.494314
100R:R:F428 7.594508
101R:R:P431 4.288517
102R:R:F432 5.154514
103R:R:T437 5.43754184
104R:R:D444 5.1375418
105R:R:F446 5.135417
106R:R:D448 5.89571717
107R:R:R452 6.774184
108R:R:Y453 4.6325818
109R:R:F456 4.715405
110R:R:Y468 4.5354134
111R:R:V471 3.955417
112R:R:G472 2.1325419
113R:R:W474 5.67333616
114R:R:L478 4.026516
115R:R:L480 4.6125416
116R:R:I485 4.982517
117R:R:P486 3.706513
118R:R:W487 5.88143717
119R:R:C500 4.16754149
120R:R:P514 2.50754145
121R:R:E516 4.48754144
122R:R:C519 5.064149
123R:R:Y528 8.04648
124R:R:E529 9.728548
125R:R:Y530 7.3425447
126R:R:R531 7.516547
127R:R:C540 4.5975449
128R:R:W545 10.125446
129R:R:P546 6.73448
130R:R:Q558 4.84754324
131R:R:W563 9.382505
132R:R:P571 2.8025408
133R:R:G578 2.235466
134R:R:T582 5.51567
135R:R:H592 8.4825404
136R:R:T595 4.5745349
137R:R:L605 7.2085198
138R:R:L609 5.0675408
139R:R:L610 4.87167669
140R:R:V613 5.445468
141R:R:Y617 5.995468
142R:R:T633 2.944535
143R:R:R636 11.582538
144R:R:L637 2.656534
145R:R:R656 4.83254198
146R:R:Q679 5.0375408
147R:R:I687 2.6425407
148R:R:W697 8.235407
149R:R:L698 6.88436
150R:R:K707 4.40254322
151R:R:P711 5.07254365
152R:R:R720 5.948506
153R:R:M728 8.5825437
154R:R:M766 3.5765229
155R:R:I772 5.07754158
156R:R:W773 5.9845159
157R:R:F776 7.58254159
158R:R:T783 5.48254377
159R:R:V789 4.0354375
160R:R:L806 3.62167668
161S:S:G30 1.7325409
162S:S:L32 3.60754115
163S:S:L34 4.245407
164S:S:F38 5.688518
165S:S:P39 3.0725415
166S:S:H41 5.774518
167S:S:R57 7.51404
168S:S:R61 6.66333614
169S:S:L62 4.23415
170S:S:E63 13.0575418
171S:S:A64 3.1075417
172S:S:M65 4.9025409
173S:S:F67 5.974507
174S:S:L78 4.52167617
175S:S:H87 5.18333614
176S:S:I88 4.9525417
177S:S:L89 10.668515
178S:S:D90 7.262519
179S:S:C92 5.114518
180S:S:K94 5.9975413
181S:S:H97 5.87513
182S:S:L99 4.2625415
183S:S:Q101 8.0925415
184S:S:H119 5.822573
185S:S:Y126 5.67167672
186S:S:D131 7.122572
187S:S:I136 2.905406
188S:S:T137 3.9425404
189S:S:I140 4.785407
190S:S:S143 4.38514
191S:S:Y144 7.99513
192S:S:N153 5.9475415
193S:S:L154 3.3975405
194S:S:L157 4.2925105
195S:S:F158 5.345106
196S:S:P161 2.702599
197S:S:Y165 6.78429718
198S:S:L172 5.99286717
199S:S:R177 5.705615
200S:S:Y178 6.975616
201S:S:Y180 7.798596
202S:S:F181 6.12571719
203S:S:R183 5.865419
204S:S:V185 4.55417
205S:S:P186 3.715618
206S:S:P187 5.88333617
207S:S:D188 4.3875418
208S:S:F190 4.28571715
209S:S:Q191 10.07418
210S:S:E197 3.01416
211S:S:F202 9.7675418
212S:S:W204 7.112519
213S:S:Y206 4.886509
214S:S:T209 3.2975416
215S:S:Y216 4.15667617
216S:S:T219 3.15414
217S:S:F224 3.55833617
218S:S:E225 4.786514
219S:S:R231 6.78514
220S:S:V241 4.9054166
221S:S:F250 9.3245163
222S:S:E251 3.3975402
223S:S:V265 4.5275408
224S:S:F269 4.065617
225S:S:D274 5.23254164
226S:S:F289 6.3475406
227S:S:W291 6.2056167
228S:S:S294 7.305418
229S:S:D295 7.6125418
230S:S:W297 4.7425886
231S:S:V303 3.07504
232S:S:E312 5.51254235
233S:S:L319 3.6325414
234S:S:F327 5.674518
235S:S:F331 8.904516
236S:S:L334 6.6275415
237S:S:P336 4.9625416
238S:S:W337 2.9575413
239S:S:N342 6.0825417
240S:S:P343 5.405412
241S:S:W344 5.85889914
242S:S:F345 5.735404
243S:S:F348 9.188516
244S:S:W349 5.45618
245S:S:F353 10.18417
246S:S:F357 5.22833613
247S:S:K377 4.612513
248S:S:M379 7.7275418
249S:S:F380 7.37516
250S:S:V382 2.314518
251S:S:N383 4.962518
252S:S:Y386 4.37571716
253S:S:M388 2.945406
254S:S:C400 4.66403
255S:S:L406 3.7845112
256S:S:C407 3.4407
257S:S:Y419 5.48833695
258S:S:F422 7.288504
259S:S:F428 9.195408
260S:S:P431 4.614517
261S:S:F432 5.554514
262S:S:R433 4.04503
263S:S:N439 4.9175405
264S:S:D444 5.435418
265S:S:F446 6.0525417
266S:S:D448 5.30286717
267S:S:Y453 4.6625818
268S:S:F456 5.845485
269S:S:Y468 3.9925484
270S:S:K470 6.4875405
271S:S:V471 3.77517
272S:S:W474 4.76286716
273S:S:L478 4.312516
274S:S:L480 5.2225416
275S:S:I485 4.806517
276S:S:W487 5.32714717
277S:S:C500 3.7375429
278S:S:K510 3.885427
279S:S:P514 2.5075425
280S:S:E516 4.4875424
281S:S:C519 5.06429
282S:S:Y528 9.392528
283S:S:E529 9.64528
284S:S:Y530 7.742527
285S:S:C540 5.2675429
286S:S:W545 8.62426
287S:S:P546 5.34428
288S:S:C553 6.19429
289S:S:W563 8.6756435
290S:S:T582 6.27457
291S:S:L586 4.41505
292S:S:F589 3.946676449
293S:S:H592 8.69404
294S:S:T595 5.7585209
295S:S:V597 4.15254207
296S:S:L610 3.84509
297S:S:V613 6.935458
298S:S:Y617 6.86558
299S:S:F621 8.935457
300S:S:R636 8.56833638
301S:S:L637 3.312534
302S:S:L639 5.005438
303S:S:T641 3.5525436
304S:S:Y647 10.69254176
305S:S:S648 3.07754179
306S:S:T652 6.3875407
307S:S:R656 3.0625408
308S:S:Q679 6.594458
309S:S:I687 3.9465177
310S:S:Q690 5.97254179
311S:S:W697 8.8175407
312S:S:L698 7.1425436
313S:S:R720 6.6975406
314S:S:M728 4.50667637
315S:S:V736 3.305405
316S:S:W773 5.2325409
317S:S:T783 2.7045477
318S:S:Y787 3.875405
319S:S:Q790 5.2325407
320S:S:V805 2.375407
321S:S:L806 5.764558
322S:S:P812 3.18409
323S:S:Y815 5.2175407
324S:S:Q820 6.65254206
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:G36 R:R:I88 15.23973.53YesYes187
2R:R:G30 R:R:G85 21.40552.11NoNo098
3R:R:G85 R:R:V33 22.29563.68NoNo085
4R:R:I136 R:R:V33 23.18553.07YesNo065
5R:R:D31 R:R:G30 19.62481.68NoNo089
6R:R:D31 R:R:L406 17.84214.07NoYes2482
7R:R:L34 R:R:T137 12.62592.95YesYes074
8R:R:G36 R:R:V139 22.57531.84YesNo187
9R:R:K377 R:R:R61 16.32358.66YesYes134
10R:R:I72 R:R:Y386 13.36018.46NoYes096
11R:R:I72 R:R:L84 14.07182.85NoYes099
12R:R:L154 R:R:L155 49.04352.77YesYes056
13R:R:L155 R:R:Q162 30.10722.66YesYes168
14R:R:Q162 R:R:V139 28.12422.87YesNo187
15R:R:L154 S:S:F158 18.85682.44YesYes056
16S:S:I136 S:S:I160 13.83022.94YesNo066
17S:S:I160 S:S:L155 26.32085.71NoNo066
18S:S:L154 S:S:L155 37.96982.77YesNo056
19R:R:F158 S:S:L154 19.01322.44YesYes065
20R:R:F158 R:R:L154 22.74383.65YesYes065
21S:S:F158 S:S:L154 19.14153.65YesYes065
22R:R:I136 R:R:I160 26.53272.94YesYes066
23R:R:I160 R:R:L155 25.87525.71YesYes166
24R:R:G138 R:R:T137 14.6361.82NoYes174
25R:R:F181 R:R:Q162 23.644110.54YesYes198
26R:R:A152 R:R:Y178 16.16382.67NoYes176
27R:R:A152 R:R:Q162 15.74484.55NoYes178
28R:R:D179 R:R:R156 17.57677.15NoYes075
29R:R:R156 S:S:N153 16.32773.62YesYes055
30R:R:R177 R:R:Y178 91.61134.12YesYes156
31R:R:R177 S:S:R177 91.51787.46YesYes155
32R:R:P161 R:R:Y419 17.07422.78YesYes195
33R:R:Y180 R:R:Y419 16.44148.94YesYes165
34R:R:F181 R:R:R183 23.41088.55YesYes199
35R:R:K377 R:R:L319 16.18822.82YesYes134
36R:R:L319 R:R:Y453 15.01652.34YesYes148
37R:R:P187 R:R:R183 80.80748.65YesYes179
38R:R:D448 R:R:R183 20.59897.15YesYes179
39R:R:F189 R:R:P187 19.82358.67YesYes137
40R:R:D448 R:R:F189 20.3052.39YesYes173
41R:R:W474 R:R:Y453 12.12673.86YesYes168
42R:R:A192 R:R:A223 39.35731.79NoNo053
43R:R:A223 R:R:F189 40.09641.39NoYes033
44R:R:A192 R:R:F224 39.00881.39NoYes057
45R:R:A196 R:R:E197 53.21511.51NoNo066
46R:R:E197 R:R:W474 49.37855.45NoYes166
47R:R:A196 R:R:E227 53.09426.03NoNo065
48R:R:L478 R:R:W474 15.78516.83YesYes166
49R:R:F224 R:R:L199 41.35882.44YesNo076
50R:R:L199 R:R:W204 20.78434.56NoYes069
51R:R:F201 R:R:L478 17.55583.65NoYes156
52R:R:F201 R:R:F202 17.42356.43NoYes158
53R:R:F202 R:R:W204 13.960220.04YesYes189
54R:R:L199 R:R:V207 20.42685.96NoNo068
55R:R:E227 R:R:R231 52.973415.12NoYes054
56R:R:R200 R:R:R231 52.61283.2NoYes044
57R:R:I233 R:R:R200 52.49253.76NoNo064
58R:R:V265 R:R:W204 33.79493.68YesYes089
59R:R:V207 R:R:V265 20.15936.41NoYes088
60R:R:I233 R:R:T205 52.25453.04NoNo067
61R:R:R499 R:R:T205 52.13555.17NoNo057
62R:R:A236 R:R:Y206 46.64286.67NoYes089
63R:R:S498 R:R:Y206 50.98563.82NoYes099
64R:R:S498 R:R:V265 52.43214.85NoYes098
65R:R:A236 R:R:T237 45.91851.68NoNo086
66R:R:S208 R:R:T237 26.24323.2NoNo086
67R:R:E239 R:R:T237 18.95399.88NoNo056
68R:R:A266 R:R:S208 22.6043.42NoNo068
69R:R:F250 R:R:V253 14.58963.93YesNo035
70R:R:E239 R:R:V253 15.31572.85NoNo055
71R:R:C500 R:R:R499 51.78481.39YesNo095
72R:R:A266 R:R:W291 21.87822.59NoYes067
73R:R:L279 R:R:W297 13.16873.42NoYes056
74R:R:L279 R:R:W291 16.08814.56NoYes057
75R:R:L406 R:R:M410 15.17072.83YesNo022
76R:R:L399 R:R:M410 14.27942.83NoNo032
77R:R:C500 R:R:E516 50.27434.56YesYes1494
78R:R:E516 R:R:L521 50.10512.65YesNo1446
79R:R:L521 R:R:V512 50.10341.49NoNo062
80R:R:I523 R:R:V512 49.99094.61NoNo042
81R:R:I523 R:R:K510 49.42875.82NoNo047
82R:R:C537 R:R:K510 49.31863.23NoNo097
83R:R:C537 R:R:E529 49.06369.12NoYes498
84R:R:E529 R:R:Y528 48.55442.24YesYes488
85R:R:W545 R:R:Y528 48.27089.65YesYes468
86R:R:P711 R:R:R714 45.51828.65YesNo054
87R:R:E715 R:R:R714 45.62786.98NoNo054
88R:R:E715 R:R:W545 45.957617.45NoYes056
89R:R:P711 R:R:Y787 43.94242.78YesNo3655
90R:R:L719 R:R:Y787 43.87854.69NoNo075
91R:R:L719 R:R:R562 12.09292.43NoNo076
92R:R:R562 R:R:W563 10.842112NoYes065
93R:R:I624 R:R:W563 10.524314.09NoYes075
94R:R:L719 R:R:R720 31.86742.43NoYes076
95R:R:I624 R:R:P571 10.17941.69NoYes078
96R:R:Q790 R:R:R720 13.20135.84NoYes076
97R:R:F780 R:R:Q790 12.31059.37NoNo087
98R:R:F776 R:R:F780 11.51487.5YesNo1598
99R:R:F776 R:R:W773 11.23053.01YesYes1599
100R:R:S801 R:R:W773 14.29448.65NoYes1599
101R:R:G802 R:R:S801 14.11921.86NoNo089
102R:R:G802 R:R:L806 10.08761.71NoYes088
103R:R:L806 R:R:T582 10.47274.42YesYes687
104R:R:F643 R:R:L639 10.05746.09NoNo088
105R:R:F623 R:R:R635 18.989113.9NoNo088
106R:R:R635 R:R:R720 19.33413.2NoYes086
107R:R:F623 R:R:M619 15.53192.49NoNo087
108R:R:G638 R:R:M619 15.13886.99NoNo067
109R:R:G638 R:R:L637 14.59631.71NoYes364
110R:R:L637 R:R:V695 13.37472.98YesNo343
111R:R:V695 S:S:V695 15.99211.6NoNo333
112S:S:L637 S:S:V695 13.40242.98YesNo343
113S:S:L637 S:S:T641 13.89185.9YesYes346
114S:S:L155 S:S:V151 12.22532.98NoNo065
115S:S:Q162 S:S:V151 12.12528.6NoNo085
116S:S:Q162 S:S:V139 23.11692.87NoNo087
117S:S:G35 S:S:V139 22.89213.68NoNo097
118S:S:G35 S:S:G36 22.68262.11NoNo098
119S:S:G36 S:S:I88 19.57491.76NoYes087
120S:S:I88 S:S:W344 12.31062.35YesYes174
121S:S:F105 S:S:I136 10.38362.51NoYes066
122S:S:I160 S:S:P161 26.92093.39NoYes069
123S:S:G138 S:S:P161 28.95982.03NoYes079
124S:S:G138 S:S:T137 15.00893.64NoYes074
125S:S:G138 S:S:M388 13.67891.75NoYes076
126S:S:I140 S:S:L34 12.97634.28YesYes077
127S:S:R177 S:S:Y178 1007.2YesYes156
128S:S:A152 S:S:Y178 17.81265.34NoYes076
129S:S:A152 S:S:F181 17.78672.77NoYes079
130S:S:F181 S:S:S164 20.28116.61YesNo199
131S:S:G142 S:S:S164 20.03371.86NoNo059
132S:S:G141 S:S:G142 15.78692.11NoNo085
133S:S:L172 S:S:Y178 92.943110.55YesYes176
134S:S:F181 S:S:L172 18.32477.31YesYes197
135S:S:G141 S:S:Y165 15.52012.9NoYes088
136S:S:L172 S:S:R183 84.63763.64YesYes179
137S:S:P187 S:S:R183 88.81698.65YesYes179
138S:S:P186 S:S:P187 25.511.95YesYes187
139S:S:K377 S:S:R61 10.79058.66YesYes134
140S:S:L62 S:S:N342 11.20285.49YesYes157
141S:S:F345 S:S:N342 17.03796.04YesYes047
142S:S:I140 S:S:V385 19.8214.61YesNo079
143S:S:V385 S:S:Y386 18.19362.52NoYes196
144S:S:F380 S:S:M379 18.57147.46YesYes168
145S:S:M379 S:S:N383 16.56938.41YesYes188
146S:S:F380 S:S:L319 12.61256.09YesYes164
147S:S:I72 S:S:Y386 16.48818.46NoYes196
148S:S:I72 S:S:L78 13.71732.85NoYes197
149S:S:I149 S:S:N153 10.29882.83NoYes155
150S:S:L157 S:S:R156 10.30052.43YesNo055
151S:S:D179 S:S:R156 10.384721.44NoNo075
152S:S:D179 S:S:Y180 10.49119.2NoYes076
153S:S:Y180 S:S:Y419 10.736510.92YesYes965
154S:S:F190 S:S:P187 58.2832.89YesYes157
155S:S:F190 S:S:W474 63.21012YesYes156
156S:S:I317 S:S:Y453 16.75983.63NoYes168
157S:S:E197 S:S:W474 54.08174.36YesYes166
158S:S:I317 S:S:M195 16.43654.37NoNo067
159S:S:F224 S:S:M195 15.75672.49YesNo077
160S:S:E197 S:S:R231 59.93182.33YesYes164
161S:S:L478 S:S:W474 21.83316.83YesYes166
162S:S:L478 S:S:L480 14.39854.15YesYes166
163S:S:F201 S:S:L478 12.97273.65NoYes156
164S:S:F201 S:S:F202 12.79157.5NoYes158
165S:S:F224 S:S:V207 13.36092.62YesNo178
166S:S:R200 S:S:R231 59.173613.86NoYes144
167S:S:I233 S:S:R200 59.16212.51NoNo064
168S:S:V207 S:S:V265 13.06756.41NoYes088
169S:S:I233 S:S:T205 58.9663.04NoNo067
170S:S:R499 S:S:T205 58.87499.06NoNo057
171S:S:S498 S:S:V265 20.28624.85NoYes098
172S:S:R264 S:S:S498 12.77876.59NoNo069
173S:S:F289 S:S:R264 12.28022.14YesNo066
174S:S:G472 S:S:L480 14.21571.71NoYes096
175S:S:G472 S:S:K470 11.2925.23NoYes095
176S:S:F456 S:S:K470 10.42614.96YesYes055
177S:S:C500 S:S:R499 58.60791.39YesNo095
178S:S:C500 S:S:E516 56.93394.56YesYes294
179S:S:E516 S:S:L521 57.51422.65YesNo246
180S:S:L521 S:S:V512 57.66411.49NoNo262
181S:S:K510 S:S:V512 56.72884.55YesNo272
182S:S:C525 S:S:K510 28.5294.85NoYes297
183S:S:C537 S:S:K510 28.5293.23NoYes297
184S:S:C525 S:S:E529 28.4036.08NoYes298
185S:S:C537 S:S:E529 28.4036.08NoYes298
186S:S:E529 S:S:Y528 55.50688.98YesYes288
187S:S:R713 S:S:Y528 49.30153.09NoYes238
188S:S:R713 S:S:R714 49.57152.13NoNo034
189S:S:P711 S:S:R714 50.00238.65NoNo054
190S:S:A710 S:S:P711 46.1211.87NoNo035
191S:S:A710 S:S:Y787 45.82445.34NoYes035
192S:S:R720 S:S:Y787 40.78292.06YesYes065
193S:S:Q790 S:S:R720 39.29939.35YesYes076
194S:S:F780 S:S:Q790 36.03015.86NoYes087
195S:S:F776 S:S:F780 35.73236.43NoNo098
196S:S:F776 S:S:M794 33.646314.93NoNo099
197S:S:M794 S:S:V798 33.3484.56NoNo098
198S:S:S801 S:S:V798 32.15583.23NoNo098
199S:S:G802 S:S:S801 31.85753.71NoNo089
200S:S:G802 S:S:V805 31.55941.84NoYes087
201S:S:L809 S:S:V805 30.68794.47NoYes087
202S:S:L609 S:S:L809 30.45788.3NoNo088
203S:S:L609 S:S:V613 14.88682.98NoYes088
204S:S:T582 S:S:V613 12.89917.93YesYes578
205S:S:S644 S:S:T641 14.56783.2NoYes086
206S:S:I687 S:S:S644 14.15016.19YesNo078
207S:S:L610 S:S:V585 10.03462.98YesNo096
208S:S:C683 S:S:S648 13.23623.44NoYes079
209S:S:C683 S:S:T652 13.47335.07NoYes077
210S:S:A649 S:S:L609 15.86126.3NoNo088
211R:R:N153 S:S:L157 13.55834.12NoYes055
212R:R:D179 R:R:Y180 17.33015.75NoYes076
213R:R:F190 R:R:P187 53.33815.78YesYes157
214R:R:F190 R:R:W474 53.33232YesYes156
215S:S:F181 S:S:Q162 21.921910.54YesNo098
216S:S:L610 S:S:T582 11.42174.42YesYes097
217S:S:A649 S:S:T652 15.69421.68NoYes087
218R:R:L34 R:R:L84 11.56566.92YesYes079
219S:S:I149 S:S:L172 10.29115.71NoYes157
220S:S:N153 S:S:Y178 10.72310.47YesYes156
221S:S:D444 S:S:F190 14.18992.39YesYes185
222R:R:L172 R:R:R183 77.89914.86YesYes179
223R:R:L172 R:R:Y178 80.567210.55YesYes176
224S:S:P161 S:S:Y419 16.46442.78YesYes995
225S:S:L319 S:S:Y453 13.60522.34YesYes148
226S:S:W474 S:S:Y453 13.20793.86YesYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPA
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu2; mGlu2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.6
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03641-w
Net Summary
Imin 1.68
Number of Linked Nodes 1446
Number of Links 1850
Number of Hubs 324
Number of Links mediated by Hubs 1173
Number of Communities 47
Number of Nodes involved in Communities 529
Number of Links involved in Communities 796
Path Summary
Number Of Nodes in MetaPath 227
Number Of Links MetaPath 226
Number of Shortest Paths 3831109
Length Of Smallest Path 3
Average Path Length 32.6479
Length of Longest Path 73
Minimum Path Strength 1.255
Average Path Strength 5.13583
Maximum Path Strength 21.29
Minimum Path Correlation 0.7
Average Path Correlation 0.997565
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 63.0155
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.8217
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon
SCOP2Domain Identifier• Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7EPA_Chain_R
KVLTLEGDL VLGGLFPVH QKGGPAEDC GPVNEHRGI QRLEAMLFA 
LDRINRDPH LLPGVRLGA HILDSCSKD THALEQALD FVRASLSRG 
ADGSRHICP DGSYATHGD APTAITGVI GGSYSDVSI QVANLLRLF 
QIPQISYAS TSAKLSDKS RYDYFARTV PPDFFQAKA MAEILRFFN 
WTYVSTVAS EGDYGETGI EAFELEARA RNICVATSE KVGRAMSRA 
AFEGVVRAL LQKPSARVA VLFTRSEDA RELLAASQR LNASFTWVA 
SDGWGALES VVAGSEGAA EGAITIELA SYPISDFAS YFQSLDPWN 
NSRNPWFRE FWEQRFRCS FRQRDCAAH SLRAVPFEQ ESKIMFVVN 
AVYAMAHAL HNMHRALCP NTTRLCDAM RPVNGRRLY KDFVLNVKF 
DAPFRPADT HNEVRFDRF GDGIGRYNI FTYLRAGSG RYRYQKVGY 
WAEGLTLDT SLIPWASPS AGPLPASRC SEPCLQNEV KSVQPGEVC 
CWLCIPCQP YEYRLDEFT CADCGLGYW PNASLTGCF ELPQEYIRW 
GDAWAVGPV TIACLGALA TLFVLGVFV RHNATPVVK ASGRELCYI 
LLGGVFLCY CMTFIFIAK PSTAVCTLR RLGLGTAFS VCYSALLTK 
TYRIAISPA SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER 
REVVTLRCN HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE 
AKFIGFTMY TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS 
VVLGCLFAP KLYIILFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7EPA_Chain_S
KVLTLEGDL VLGGLFPVH QKGGPAEDC GPVNEHRGI QRLEAMLFA 
LDRINRDPH LLPGVRLGA HILDSCSKD THALEQALD FVRASLSRG 
ADGSRHICP DGSYATHGD APTAITGVI GGSYSDVSI QVANLLRLF 
QIPQISYAS TSAKLSDKS RYDYFARTV PPDFFQAKA MAEILRFFN 
WTYVSTVAS EGDYGETGI EAFELEARA RNICVATSE KVGRAMSRA 
AFEGVVRAL LQKPSARVA VLFTRSEDA RELLAASQR LNASFTWVA 
SDGWGALES VVAGSEGAA EGAITIELA SYPISDFAS YFQSLDPWN 
NSRNPWFRE FWEQRFRCS FRQRDCAAH SLRAVPFEQ ESKIMFVVN 
AVYAMAHAL HNMHRALCP NTTRLCDAM RPVNGRRLY KDFVLNVKF 
DAPFRPADT HNEVRFDRF GDGIGRYNI FTYLRAGSG RYRYQKVGY 
WAEGLTLDT SLIPWASPS AGPLPASRC SEPCLQNEV KSVQPGEVC 
CWLCIPCQP YEYRLDEFT CADCGLGYW PNASLTGCF ELPQEYIRW 
GDAWAVGPV TIACLGALA TLFVLGVFV RHNATPVVK ASGRELCYI 
LLGGVFLCY CMTFIFIAK PSTAVCTLR RLGLGTAFS VCYSALLTK 
TYRIAISPA SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER 
REVVTLRCN HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE 
AKFIGFTMY TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS 
VVLGCLFAP KLYIILFQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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