Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F38 8.09478
2R:R:P39 5.26575
3R:R:V40 5.34833616
4R:R:H41 8.578518
5R:R:V53 5.735413
6R:R:R57 10.186574
7R:R:R61 11.7925474
8R:R:E63 5.15718
9R:R:R71 10.89754227
10R:R:I72 4.5054129
11R:R:L78 5.2765127
12R:R:H87 7.414584
13R:R:I88 6.026507
14R:R:L89 7.276585
15R:R:D90 8.045419
16R:R:C92 7.78418
17R:R:F105 7.86586
18R:R:H119 9.34754243
19R:R:V139 5.6275487
20R:R:S143 7.29474
21R:R:L155 5.0725486
22R:R:R156 8.1175425
23R:R:L157 4.944525
24R:R:F158 10.004526
25R:R:Y165 9.798578
26R:R:L172 6.552557
27R:R:Y178 9.884556
28R:R:Y180 6.454266
29R:R:F181 9.33459
30R:R:R183 9.254559
31R:R:P186 6.10254278
32R:R:P187 8.5075457
33R:R:F189 5.77553
34R:R:F190 7.8675455
35R:R:Q191 6.875408
36R:R:F202 10.2525498
37R:R:W204 11.028599
38R:R:Y206 4.07571709
39R:R:T209 5.61754286
40R:R:F224 5.1245287
41R:R:E239 6.65405
42R:R:V265 8.01498
43R:R:V267 6.684286
44R:R:W291 5.07833667
45R:R:W297 5.25714766
46R:R:T316 3.9075467
47R:R:L319 4.9645274
48R:R:Y322 7.3754323
49R:R:F327 8.42518
50R:R:F331 5.018516
51R:R:L334 6.92515
52R:R:N342 5.938517
53R:R:W344 5.528514
54R:R:F345 4.6625414
55R:R:W349 7.802518
56R:R:R352 9.5175413
57R:R:F353 9.8375417
58R:R:F372 5.355615
59R:R:Q374 4.854515
60R:R:I378 8.98417
61R:R:F380 7.604506
62R:R:Y386 9.0925406
63R:R:M395 5.785405
64R:R:C400 3.8725403
65R:R:L406 6.8525172
66R:R:Y419 6.276505
67R:R:F422 4.2554334
68R:R:F428 9.4075408
69R:R:R433 7.524323
70R:R:N439 6.49254325
71R:R:D448 9.635457
72R:R:Y453 7.545278
73R:R:F456 4.29465
74R:R:Y468 7.266564
75R:R:V471 3.4975407
76R:R:W474 6.1375406
77R:R:L478 3.896596
78R:R:I485 5.86407
79R:R:W487 6.23833697
80R:R:C500 4.484299
81R:R:C525 4.1954189
82R:R:Y530 8.564347
83R:R:V585 4.02754376
84R:R:L586 4.4585385
85R:R:T595 4.3565399
86R:R:M619 3.975407
87R:R:K626 6.7165354
88R:R:S628 3.20754355
89R:R:R636 5.535408
90R:R:L639 4.5075408
91R:R:Y647 4.436506
92R:R:K653 3.5225409
93R:R:Q690 3.624409
94R:R:V694 4.25754406
95R:R:R714 5.3385154
96R:R:V716 5.1075405
97R:R:H723 9.235165
98R:R:L737 2.5375404
99R:R:C752 1.684508
100R:R:M766 6.465419
101R:R:W773 5.495409
102R:R:F776 9.4565429
103R:R:R788 7.0725155
104R:R:I817 8.835409
105S:S:F55 6.20333639
106S:S:V57 6.90167645
107S:S:H58 7.445448
108S:S:C67 5.08448
109S:S:K71 7.75167645
110S:S:I76 6.5425447
111S:S:R78 5.79571734
112S:S:E80 6.545448
113S:S:M82 5.642538
114S:S:Y84 9.415407
115S:S:I89 6.73754469
116S:S:L95 5.19754467
117S:S:P97 3.29408
118S:S:L101 3.50667609
119S:S:R104 7.8875425
120S:S:I105 5.3675437
121S:S:L106 4.805404
122S:S:D107 6.6425448
123S:S:Y114 10.485404
124S:S:F122 5.28626
125S:S:F144 10.5754241
126S:S:V151 3.4525404
127S:S:S157 5.9225435
128S:S:S162 4.62428
129S:S:N167 7.882525
130S:S:Q176 6.1628
131S:S:S178 4.62428
132S:S:Y179 11.5025437
133S:S:L186 4.38428
134S:S:R191 9.525425
135S:S:Y192 7.52626
136S:S:F194 8.1325407
137S:S:F195 4.57333628
138S:S:R197 5.954529
139S:S:P200 5.415437
140S:S:P201 8.755428
141S:S:D202 5.3175409
142S:S:Q205 8.065439
143S:S:K214 2.814485
144S:S:W218 7.15609
145S:S:K233 6.99254474
146S:S:Q252 6.36754116
147S:S:I256 6.488505
148S:S:F267 5.62503
149S:S:Q273 6.425113
150S:S:V284 4.9825406
151S:S:F286 7.23437
152S:S:D289 7.94103
153S:S:D291 6.015404
154S:S:Q304 4.8975404
155S:S:W310 9.434496
156S:S:W316 5.4654108
157S:S:P322 5.7145103
158S:S:D328 4.55254133
159S:S:I329 7.8525404
160S:S:F346 6.42254458
161S:S:N361 7.5475448
162S:S:W363 5.68857745
163S:S:F364 7.11167645
164S:S:Y367 8.0375446
165S:S:W368 6.5425408
166S:S:L376 3.965403
167S:S:Q404 8.52254455
168S:S:K407 4.9375434
169S:S:F410 8.2775437
170S:S:M425 4.42406
171S:S:C437 4.62407
172S:S:Y451 4.05405
173S:S:F457 5.86833609
174S:S:D472 8.5475428
175S:S:Y477 6.71833639
176S:S:D478 6.21754147
177S:S:F480 5.63254145
178S:S:Q481 5.7225408
179S:S:Y482 6.204506
180S:S:Y492 6.034145
181S:S:I495 5.158508
182S:S:W498 7.46435
183S:S:L502 4.1575436
184S:S:W511 3.8285528
185S:S:R532 8.3554536
186S:S:Y553 6.94197
187S:S:Q567 3.354195
188S:S:R568 8.7025567
189S:S:N570 6.5545207
190S:S:C576 4.9154199
191S:S:P594 4.7454577
192S:S:T618 3.7145589
193S:S:E627 6.72254596
194S:S:Y630 4.7154597
195S:S:L638 4.744606
196S:S:I642 7.335407
197S:S:I680 5.19254219
198S:S:T706 3.105408
199S:S:P726 4.015408
200S:S:M738 5.514564
201S:S:Q755 3.032507
202S:S:M767 6.6154628
203S:S:Y773 16.55254217
204S:S:Y795 5.65409
205S:S:W801 6.8185629
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L89 R:R:Q101 12.62567.99YesNo055
2R:R:H97 R:R:Q101 12.483513.6NoNo035
3R:R:C92 R:R:H97 12.174710.32YesNo083
4R:R:K377 R:R:R61 11.278212.38NoYes034
5R:R:F380 R:R:K377 15.28398.69YesNo063
6R:R:F105 R:R:L89 13.27364.87YesYes865
7R:R:F105 R:R:V139 14.87149.18YesYes867
8R:R:L155 R:R:V139 13.86035.96YesYes867
9R:R:L154 R:R:L155 16.31964.15NoYes056
10R:R:F158 R:R:L154 14.54813.65YesNo065
11R:R:F158 R:R:L157 14.18038.53YesYes265
12S:S:Q176 S:S:V153 18.063510.03YesNo286
13S:S:F122 S:S:V153 17.51515.24YesNo266
14S:S:F122 S:S:L106 15.44693.65YesYes064
15S:S:L106 S:S:Q118 14.17456.65YesNo046
16S:S:Q118 S:S:Y114 14.213224.8NoYes064
17R:R:L157 S:S:N167 12.35284.12YesYes255
18S:S:D193 S:S:R170 27.94085.96NoNo075
19S:S:D193 S:S:F194 27.742810.75NoYes077
20S:S:F194 S:S:L449 26.56927.31YesNo076
21S:S:L449 S:S:P175 13.20156.57NoNo069
22S:S:G152 S:S:P175 10.5074.06NoNo089
23S:S:G152 S:S:M418 10.3933.49NoNo086
24S:S:L51 S:S:M418 10.28568.48NoNo076
25R:R:L172 R:R:Y178 94.51365.86YesYes576
26R:R:N153 R:R:Y178 28.971513.96NoYes056
27R:R:N153 S:S:R170 25.6794.82NoNo055
28R:R:D295 R:R:Q191 12.36996.53NoYes088
29R:R:D295 R:R:L319 13.64448.14NoYes084
30R:R:F380 R:R:L319 32.87174.87YesYes064
31R:R:Q191 R:R:Y453 22.189211.27YesYes088
32R:R:L319 R:R:Y453 40.99227.03YesYes2748
33R:R:P187 R:R:R183 50.140911.53YesYes579
34R:R:R177 S:S:R191 65.55279.6NoYes055
35R:R:R177 R:R:Y178 65.74713.38NoYes056
36R:R:D448 R:R:R183 50.057115.48YesYes579
37R:R:F190 R:R:P187 49.78088.67YesYes557
38R:R:D448 R:R:F190 49.9718.36YesYes575
39R:R:F190 R:R:K193 1003.72YesNo053
40R:R:K193 R:R:W474 99.26494.64NoYes036
41R:R:W474 R:R:Y453 61.68064.82YesYes068
42R:R:Q191 R:R:S294 12.55815.78YesNo088
43R:R:F201 R:R:F202 60.73137.5NoYes958
44R:R:F201 R:R:L478 60.87223.65NoYes956
45R:R:L478 R:R:W474 63.71443.42YesYes066
46R:R:F202 R:R:W204 55.416321.05YesYes989
47R:R:S498 R:R:W204 50.83374.94NoYes999
48R:R:A263 R:R:S498 51.05443.42NoNo079
49R:R:A263 R:R:Y206 50.87592.67NoYes079
50R:R:C500 R:R:Y206 48.87774.03YesYes099
51R:R:F269 R:R:S294 12.31656.61NoNo078
52R:R:F269 R:R:G217 11.83273.01NoNo078
53R:R:G217 R:R:Y216 11.59055.79NoNo087
54R:R:R243 R:R:Y216 10.86294.12NoNo027
55R:R:G242 R:R:R243 10.37693NoNo032
56R:R:W291 R:R:W297 12.20193.75YesYes676
57R:R:D295 R:R:E318 22.72013.9NoNo086
58R:R:F456 R:R:Y468 11.78025.16YesYes654
59R:R:E318 R:R:F456 13.3924.66NoYes065
60R:R:F380 R:R:M379 15.6037.46YesNo068
61R:R:M379 R:R:N383 11.72295.61NoNo088
62R:R:F428 R:R:H390 10.735520.36YesNo086
63R:R:F428 R:R:V441 11.31513.93YesNo086
64R:R:N383 R:R:V441 11.5184.43NoNo086
65R:R:C500 R:R:S501 48.33533.44YesNo2998
66R:R:S501 R:R:W520 48.1764.94NoNo087
67R:R:C504 R:R:C522 47.26685.46NoNo099
68R:R:C522 R:R:K510 47.4491.62NoNo097
69R:R:K510 R:R:W520 47.63118.12NoNo077
70R:R:C504 R:R:N507 47.08446.3NoNo099
71R:R:E508 R:R:N507 46.719117.09NoNo069
72R:R:C525 R:R:E508 46.53623.04YesNo096
73R:R:C525 R:R:E529 45.96543.04YesNo1898
74R:R:E529 R:R:Q526 45.82328.92NoNo085
75R:R:E712 R:R:Q526 45.455114.02NoNo045
76R:R:E712 R:R:Y528 45.270817.96NoNo048
77R:R:L542 R:R:Y528 44.716712.89NoNo048
78R:R:L542 R:R:R713 44.34633.64NoNo043
79R:R:P627 R:R:W563 40.94356.76NoNo095
80R:R:R788 R:R:W563 42.07114YesNo055
81R:R:R714 R:R:R788 42.59423.2YesYes1545
82R:R:R713 R:R:R714 44.16094.26NoYes034
83R:R:K626 R:R:P627 38.85891.67YesNo049
84R:R:F623 R:R:L639 11.3787.31NoYes088
85R:R:F623 R:R:R635 11.593210.69NoNo088
86R:R:C632 R:R:R635 34.4286.96NoNo098
87R:R:C632 R:R:C721 35.01157.28NoNo099
88R:R:C721 R:R:H723 35.20568.85NoYes095
89R:R:H723 R:R:N722 36.5278.93YesNo1656
90R:R:G704 R:R:N722 37.13675.09NoNo046
91R:R:G704 R:R:T629 37.52071.82NoNo043
92R:R:S628 R:R:T629 37.71251.6YesNo053
93R:R:K626 R:R:S628 38.07843.06YesYes3545
94R:R:R635 R:R:R636 23.56437.46NoYes088
95R:R:L732 R:R:R636 20.067.29NoYes088
96R:R:L732 R:R:V736 19.85262.98NoNo085
97R:R:V736 R:R:Y647 17.98072.52NoYes056
98R:R:C646 R:R:Y647 10.35012.69NoYes066
99R:R:C646 R:R:L609 10.13491.59NoNo068
100S:S:C67 S:S:Y114 12.80054.03YesYes084
101S:S:L186 S:S:R197 58.74586.07YesYes289
102S:S:P201 S:S:R197 58.148112.97YesYes289
103S:S:F204 S:S:P201 57.98857.22NoYes058
104S:S:F204 S:S:P200 57.51094.33NoYes057
105S:S:P200 S:S:V199 20.84823.53YesNo377
106S:S:K407 S:S:V199 19.02034.55YesNo347
107S:S:K407 S:S:R78 18.52143.71YesYes344
108S:S:F55 S:S:R78 16.21075.34YesYes394
109S:S:L186 S:S:Y192 62.08093.52YesYes286
110S:S:L449 S:S:R453 13.21513.64NoNo065
111S:S:R453 S:S:S196 12.96025.27NoNo056
112S:S:I177 S:S:S196 13.22233.1NoNo066
113S:S:A414 S:S:I177 13.1173.25NoNo096
114S:S:A414 S:S:I154 13.0153.25NoNo097
115S:S:I154 S:S:M82 10.74457.29NoYes378
116S:S:F55 S:S:L79 21.56477.31YesNo095
117S:S:E80 S:S:L79 17.85767.95YesNo085
118S:S:E80 S:S:F364 14.03195.83YesYes485
119S:S:P200 S:S:Y477 48.12589.74YesYes379
120S:S:D314 S:S:Y477 22.3244.6NoYes389
121S:S:D314 S:S:Q205 22.581114.36NoYes389
122S:S:F286 S:S:Q205 18.95368.2YesYes379
123S:S:F286 S:S:V284 18.4113.93YesYes076
124S:S:V221 S:S:V284 16.97094.81NoYes076
125S:S:I336 S:S:Y477 17.21928.46NoYes069
126S:S:I336 S:S:I479 17.03654.42NoNo068
127S:S:A282 S:S:V221 14.1623.39NoNo087
128S:S:A282 S:S:W218 13.97996.48NoYes089
129S:S:I479 S:S:I495 16.49325.89NoYes088
130S:S:I495 S:S:Q481 15.83868.23YesYes088
131S:S:Q481 S:S:R516 15.29593.5YesNo083
132S:S:L216 S:S:R516 13.85674.86NoNo083
133S:S:L216 S:S:W218 13.677610.25NoYes089
134S:S:P519 S:S:W218 25.74789.46NoYes089
135S:S:P519 S:S:R281 24.99665.76NoNo1385
136S:S:H307 S:S:R281 24.62994.51NoNo1345
137S:S:D328 S:S:H307 23.87795.04YesNo1334
138S:S:D328 S:S:K300 23.13672.77YesNo033
139S:S:H326 S:S:K300 22.7639.17NoNo033
140S:S:H326 S:S:I329 22.01492.65NoYes034
141S:S:I329 S:S:W310 17.472814.09YesYes046
142S:S:I285 S:S:W310 16.3814.7NoYes056
143S:S:I285 S:S:I292 16.00392.94NoNo054
144S:S:D291 S:S:I292 15.62672.8YesNo044
145S:S:D291 S:S:I256 13.734212.59YesYes045
146S:S:F364 S:S:W368 10.52496.01YesYes058
147R:R:L172 R:R:R183 93.35234.86YesYes579
148S:S:R191 S:S:Y192 65.199716.46YesYes256
149S:S:F195 S:S:Q176 18.12575.86YesYes288
150S:S:F55 S:S:M82 12.21866.22YesYes398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPD
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu2; mGlu7
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.9
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03641-w
Net Summary
Imin 3.01
Number of Linked Nodes 1458
Number of Links 1636
Number of Hubs 205
Number of Links mediated by Hubs 762
Number of Communities 62
Number of Nodes involved in Communities 328
Number of Links involved in Communities 415
Path Summary
Number Of Nodes in MetaPath 151
Number Of Links MetaPath 150
Number of Shortest Paths 1826720
Length Of Smallest Path 3
Average Path Length 35.7179
Length of Longest Path 98
Minimum Path Strength 1.165
Average Path Strength 6.60782
Maximum Path Strength 25.775
Minimum Path Correlation 0.71
Average Path Correlation 0.996052
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 65.2118
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.4757
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • isomerase activity   • catalytic activity, acting on a protein   • peptidyl-prolyl cis-trans isomerase activity   • catalytic activity   • cis-trans isomerase activity   • RNA polymerase II CTD heptapeptide repeat modifying activity   • RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity   • RNA polymerase II CTD heptapeptide repeat P6 isomerase activity   • transforming growth factor beta receptor binding   • signaling receptor binding   • type I transforming growth factor beta receptor binding   • cytokine receptor binding   • FK506 binding   • amide binding   • macrolide binding   • activin receptor binding   • receptor serine/threonine kinase binding   • transmembrane receptor protein serine/threonine kinase binding   • RNA polymerase II CTD heptapeptide repeat P3 isomerase activity   • transmembrane transporter binding   • SMAD binding   • I-SMAD binding   • molecular function inhibitor activity   • signaling receptor inhibitor activity   • signaling receptor regulator activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • protein refolding   • primary metabolic process   • protein maturation   • protein folding   • protein metabolic process   • positive regulation of canonical NF-kappaB signal transduction   • canonical NF-kappaB signal transduction   • regulation of canonical NF-kappaB signal transduction   • activin receptor signaling pathway   • cell surface receptor protein serine/threonine kinase signaling pathway   • regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • negative regulation of activin receptor signaling pathway   • enzyme-linked receptor protein signaling pathway   • negative regulation of response to stimulus   • negative regulation of signal transduction   • transforming growth factor beta receptor superfamily signaling pathway   • regulation of activin receptor signaling pathway   • negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway   • cellular component organization   • cellular component organization or biogenesis   • supramolecular fiber organization   • amyloid fibril formation   • regulation of calcium ion transmembrane transporter activity   • regulation of calcium ion transport   • intracellular calcium ion homeostasis   • calcium ion transport   • monoatomic cation homeostasis   • monoatomic cation transport   • intracellular monoatomic ion homeostasis   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • inorganic ion transmembrane transport   • regulation of cation channel activity   • inorganic cation transmembrane transport   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • cellular localization   • inorganic ion homeostasis   • monoatomic ion transmembrane transport   • regulation of transmembrane transporter activity   • calcium ion homeostasis   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • maintenance of location in cell   • regulation of transporter activity   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • monoatomic ion transport   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • regulation of monoatomic ion transmembrane transporter activity   • calcium ion transmembrane import into cytosol   • sequestering of calcium ion   • regulation of ryanodine-sensitive calcium-release channel activity   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • amyloid precursor protein catabolic process   • regulation of protein metabolic process   • regulation of amyloid precursor protein catabolic process   • regulation of macromolecule metabolic process   • regulation of primary metabolic process   • amyloid precursor protein metabolic process   • regulation of metabolic process   • immune response   • immune system process   • regulation of immune response   • regulation of immune system process   • developmental process   • heart development   • cardiac chamber morphogenesis   • heart trabecula formation   • animal organ development   • heart morphogenesis   • circulatory system development   • anatomical structure morphogenesis   • multicellular organism development   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • cardiac chamber development   • animal organ morphogenesis   • heart trabecula morphogenesis   • trabecula formation   • trabecula morphogenesis   • system development   • T cell activation   • cell activation   • lymphocyte activation   • leukocyte activation   • negative regulation of transforming growth factor beta receptor signaling pathway   • cellular response to growth factor stimulus   • cellular response to transforming growth factor beta stimulus   • regulation of transforming growth factor beta receptor signaling pathway   • cellular response to endogenous stimulus   • regulation of cellular response to transforming growth factor beta stimulus   • response to endogenous stimulus   • regulation of cellular response to growth factor stimulus   • response to transforming growth factor beta   • transforming growth factor beta receptor signaling pathway   • response to growth factor   • protein localization   • regulation of protein localization   • regulation of cellular localization   • cellular macromolecule localization   • macromolecule localization   • 'de novo' protein folding   • system process   • regulation of system process   • sarcoplasmic reticulum calcium ion transport   • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • multicellular organismal movement   • regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion   • regulation of skeletal muscle contraction by calcium ion signaling   • release of sequestered calcium ion into cytosol by endoplasmic reticulum   • skeletal muscle contraction   • muscle contraction   • regulation of striated muscle contraction   • regulation of muscle contraction   • calcium-mediated signaling   • striated muscle contraction   • musculoskeletal movement   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • nervous system process   • neuromuscular process   • muscle system process   • regulation of muscle system process   • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum   • ventricular cardiac muscle tissue morphogenesis   • striated muscle tissue development   • muscle structure development   • ventricular cardiac muscle tissue development   • muscle tissue development   • muscle organ development   • cardiac muscle tissue development   • tissue development   • muscle tissue morphogenesis   • tissue morphogenesis   • cardiac ventricle morphogenesis   • cardiac muscle tissue morphogenesis   • cardiac ventricle development   • muscle organ morphogenesis   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon   • membrane-bounded organelle   • intracellular anatomical structure   • organelle subcompartment   • intracellular membrane-bounded organelle   • endomembrane system   • sarcoplasm   • intracellular organelle   • endoplasmic reticulum subcompartment   • terminal cisterna   • organelle   • endoplasmic reticulum   • sarcoplasmic reticulum   • cytoplasm   • intracellular membraneless organelle   • Z disc   • sarcomere   • I band   • membraneless organelle   • contractile muscle fiber   • supramolecular fiber   • myofibril   • supramolecular polymer   • supramolecular complex   • bounding membrane of organelle   • nuclear outer membrane-endoplasmic reticulum membrane network   • sarcoplasmic reticulum membrane   • organelle membrane   • endoplasmic reticulum membrane   • cytoplasmic side of membrane   • side of membrane   • cytosol   • protein-containing complex   • membrane protein complex   • ryanodine receptor complex   • transporter complex   • endoplasmic reticulum protein-containing complex   • plasma membrane protein complex   • voltage-gated calcium channel complex   • cation channel complex   • transmembrane transporter complex   • calcium channel complex   • monoatomic ion channel complex   • protein serine/threonine kinase activity   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • DNA-dependent protein kinase activity   • catalytic activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • protein tyrosine kinase activity   • binding   • adenyl ribonucleotide binding   • nucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • adenyl nucleotide binding   • ATP binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • histone H3T6 kinase activity   • histone H3 kinase activity   • histone modifying activity   • histone kinase activity   • DNA binding   • sequence-specific DNA binding   • RNA polymerase III transcription regulatory region sequence-specific DNA binding   • RNA polymerase III type 2 promoter sequence-specific DNA binding   • double-stranded DNA binding   • nucleic acid binding   • cis-regulatory region sequence-specific DNA binding   • sequence-specific double-stranded DNA binding   • transcription cis-regulatory region binding   • RNA polymerase III cis-regulatory region sequence-specific DNA binding   • transcription regulatory region nucleic acid binding   • histone H3S57 kinase activity   • histone H4S1 kinase activity   • histone H4 kinase activity   • ribonucleoprotein complex binding   • protein-containing complex binding   • ribosome binding   • histone H3T11 kinase activity   • histone H3S28 kinase activity   • histone H2B kinase activity   • histone H2BS36 kinase activity   • ribosomal protein S6 kinase activity   • histone H3S10 kinase activity   • histone H2AS121 kinase activity   • histone H2A kinase activity   • AMP-activated protein kinase activity   • phosphoprotein binding   • protein binding   • histone H3T45 kinase activity   • eukaryotic translation initiation factor 2alpha kinase activity   • histone H3T3 kinase activity   • inositol hexakisphosphate binding   • alcohol binding   • rDNA binding   • 5S rDNA binding   • RNA polymerase III type 1 promoter sequence-specific DNA binding   • histone H2BS14 kinase activity   • identical protein binding   • transcription factor binding   • TFIIIC-class transcription factor complex binding   • RNA polymerase III general transcription initiation factor binding   • general transcription initiation factor binding   • Rho-dependent protein serine/threonine kinase activity   • histone H2AT120 kinase activity   • histone H2AXS139 kinase activity   • histone H2AX kinase activity   • protein serine kinase activity   • RNA polymerase III type 3 promoter sequence-specific DNA binding   • 3-phosphoinositide-dependent protein kinase activity   • histone H2AS1 kinase activity   • cation binding   • calcium ion binding   • metal ion binding   • enzyme regulator activity   • enzyme inhibitor activity   • phosphorus-oxygen lyase activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activity   • group III metabotropic glutamate receptor activity   • glutamate receptor activity   • G protein-coupled glutamate receptor activity   • molecular transducer activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • organic acid binding   • serine binding   • amino acid binding   • carboxylic acid binding   • PDZ domain binding   • protein domain specific binding   • protein dimerization activity   • glutamate binding   • calcineurin-NFAT signaling cascade   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • intracellular signal transduction   • cell communication   • calcium-mediated signaling   • intracellular signaling cassette   • cellular process   • signal transduction   • calcineurin-mediated signaling   • regulation of protein stability   • regulation of biological quality   • protein stabilization   • catabolic process   • macroautophagy   • autophagy   • regulation of catabolic process   • regulation of autophagy   • regulation of macroautophagy   • metabolic process   • process utilizing autophagic mechanism   • regulation of metabolic process   • regulation of cellular component organization   • autophagosome organization   • cellular component biogenesis   • cellular component organization   • cellular component assembly   • cellular component organization or biogenesis   • autophagosome assembly   • organelle assembly   • vacuole organization   • regulation of autophagosome assembly   • regulation of vacuole organization   • regulation of cellular component biogenesis   • regulation of organelle organization   • organelle organization   • regulation of organelle assembly   • regulation of cellular component size   • regulation of cell size   • regulation of anatomical structure size   • regulation of growth   • growth   • regulation of cell growth   • cell growth   • TOR signaling   • TORC1 signaling   • developmental process   • heart development   • multicellular organismal process   • heart valve development   • animal organ development   • circulatory system development   • multicellular organism development   • anatomical structure morphogenesis   • heart valve morphogenesis   • anatomical structure development   • system development   • behavior   • response to stress   • multicellular organismal response to stress   • response to pain   • behavioral response to pain   • cellular response to nutrient levels   • response to nutrient levels   • cellular response to stress   • response to starvation   • cellular response to starvation   • cellular developmental process   • regulation of developmental process   • positive regulation of biological process   • regulation of cell differentiation   • regulation of striated muscle cell differentiation   • muscle cell differentiation   • myotube differentiation   • muscle structure development   • positive regulation of developmental process   • positive regulation of myotube differentiation   • positive regulation of cell differentiation   • cell differentiation   • positive regulation of striated muscle cell differentiation   • regulation of myotube differentiation   • positive regulation of cellular process   • positive regulation of muscle cell differentiation   • regulation of muscle cell differentiation   • striated muscle cell differentiation   • positive regulation of locomotion   • regulation of cell motility   • regulation of keratinocyte migration   • positive regulation of cell migration   • positive regulation of epithelial cell migration   • tissue migration   • ameboidal-type cell migration   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • regulation of multicellular organismal process   • epithelial cell migration   • cell motility   • regulation of epithelial cell migration   • locomotion   • epithelium migration   • regulation of locomotion   • positive regulation of keratinocyte migration   • keratinocyte migration   • negative regulation of catabolic process   • negative regulation of metabolic process   • negative regulation of biological process   • negative regulation of autophagy   • negative regulation of cellular process   • response to osmotic stress   • cellular response to chemical stress   • cellular response to osmotic stress   • cellular response to environmental stimulus   • cellular response to chemical stimulus   • response to chemical   • response to abiotic stimulus   • cellular response to abiotic stimulus   • positive regulation of protein metabolic process   • positive regulation of translation   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • post-transcriptional regulation of gene expression   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • translational initiation   • protein metabolic process   • regulation of biosynthetic process   • regulation of translational initiation   • regulation of protein metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • gene expression   • translation   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • positive regulation of gene expression   • regulation of translation   • regulation of macromolecule biosynthetic process   • positive regulation of translational initiation   • macromolecule metabolic process   • multicellular organism growth   • developmental growth   • anoikis   • apoptotic process   • cell death   • programmed cell death   • cellular response to acid chemical   • cellular response to nitrogen compound   • cellular response to amino acid stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to amino acid   • cellular response to L-leucine   • cellular response to oxygen-containing compound   • response to acid chemical   • response to L-leucine   • negative regulation of signaling   • negative regulation of intracellular signal transduction   • regulation of signal transduction   • negative regulation of cell communication   • negative regulation of calcineurin-NFAT signaling cascade   • regulation of intracellular signal transduction   • regulation of calcineurin-mediated signaling   • regulation of calcium-mediated signaling   • regulation of calcineurin-NFAT signaling cascade   • regulation of signaling   • negative regulation of response to stimulus   • negative regulation of calcium-mediated signaling   • negative regulation of signal transduction   • regulation of response to stimulus   • regulation of cell communication   • negative regulation of calcineurin-mediated signaling   • response to heat   • response to temperature stimulus   • positive regulation of cell growth   • positive regulation of growth   • ribonucleotide catabolic process   • pyridine nucleotide catabolic process   • oxoacid metabolic process   • carbohydrate catabolic process   • carbohydrate derivative metabolic process   • organophosphate catabolic process   • regulation of generation of precursor metabolites and energy   • positive regulation of phosphate metabolic process   • nucleoside phosphate catabolic process   • organic acid metabolic process   • regulation of ATP metabolic process   • nucleobase-containing compound metabolic process   • regulation of purine nucleotide catabolic process   • positive regulation of nucleotide catabolic process   • regulation of small molecule metabolic process   • glycolytic process   • regulation of phosphate metabolic process   • regulation of nucleotide metabolic process   • phosphate-containing compound metabolic process   • pyridine-containing compound metabolic process   • small molecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • purine ribonucleotide catabolic process   • phosphorus metabolic process   • pyridine nucleotide metabolic process   • nucleoside phosphate metabolic process   • nicotinamide nucleotide metabolic process   • pyruvate metabolic process   • regulation of carbohydrate catabolic process   • positive regulation of nucleobase-containing compound metabolic process   • positive regulation of phosphorus metabolic process   • purine nucleoside diphosphate metabolic process   • purine-containing compound catabolic process   • nucleotide metabolic process   • regulation of purine nucleotide metabolic process   • nucleobase-containing compound catabolic process   • positive regulation of ATP metabolic process   • nucleoside diphosphate metabolic process   • purine nucleoside diphosphate catabolic process   • nucleoside diphosphate catabolic process   • regulation of phosphorus metabolic process   • regulation of nucleotide catabolic process   • positive regulation of carbohydrate metabolic process   • nucleoside triphosphate metabolic process   • monocarboxylic acid metabolic process   • purine ribonucleotide metabolic process   • pyridine-containing compound catabolic process   • ribose phosphate metabolic process   • ATP metabolic process   • positive regulation of nucleotide metabolic process   • positive regulation of purine nucleotide catabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • nucleobase-containing small molecule metabolic process   • purine ribonucleoside triphosphate metabolic process   • ribonucleoside diphosphate metabolic process   • ribonucleoside diphosphate catabolic process   • regulation of carbohydrate metabolic process   • ribonucleoside triphosphate metabolic process   • nucleotide catabolic process   • purine nucleoside triphosphate metabolic process   • carbohydrate metabolic process   • purine nucleotide catabolic process   • carbohydrate derivative catabolic process   • positive regulation of glycolytic process   • ADP catabolic process   • carboxylic acid metabolic process   • generation of precursor metabolites and energy   • regulation of glycolytic process   • purine-containing compound metabolic process   • positive regulation of purine nucleotide metabolic process   • positive regulation of catabolic process   • ADP metabolic process   • organophosphate metabolic process   • purine ribonucleoside diphosphate metabolic process   • positive regulation of small molecule metabolic process   • purine ribonucleoside diphosphate catabolic process   • voluntary musculoskeletal movement   • multicellular organismal movement   • musculoskeletal movement   • system process   • nervous system process   • neuromuscular process   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • cell development   • cellular process involved in reproduction in multicellular organism   • developmental process involved in reproduction   • gamete generation   • germ cell development   • rhythmic process   • circadian rhythm   • regulation of circadian rhythm   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • negative regulation of apoptotic process   • regulation of epithelial to mesenchymal transition   • positive regulation of epithelial to mesenchymal transition   • mesenchyme development   • tissue development   • epithelial to mesenchymal transition   • positive regulation of multicellular organismal process   • mesenchymal cell differentiation   • lytic vacuole organization   • lysosome organization   • regulation of lysosome organization   • regulation of cytoskeleton organization   • regulation of actin filament-based process   • actin cytoskeleton organization   • regulation of actin cytoskeleton organization   • actin filament-based process   • cytoskeleton organization   • cellular response to methionine   • response to nutrient   • response to methionine   • cellular response to nutrient   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • osteoclast differentiation   • regulation of immune system process   • regulation of multicellular organismal development   • hemopoiesis   • regulation of myeloid cell differentiation   • regulation of myeloid leukocyte differentiation   • myeloid cell differentiation   • immune system process   • regulation of hemopoiesis   • leukocyte differentiation   • positive regulation of organelle organization   • positive regulation of cellular component organization   • regulation of protein-containing complex assembly   • positive regulation of protein-containing complex assembly   • positive regulation of protein polymerization   • protein-containing complex assembly   • regulation of actin filament polymerization   • protein polymerization   • actin polymerization or depolymerization   • regulation of actin filament organization   • actin filament polymerization   • protein-containing complex organization   • positive regulation of cellular component biogenesis   • positive regulation of cytoskeleton organization   • regulation of actin polymerization or depolymerization   • actin filament organization   • positive regulation of supramolecular fiber organization   • regulation of protein polymerization   • regulation of actin filament length   • regulation of supramolecular fiber organization   • supramolecular fiber organization   • positive regulation of actin filament polymerization   • cardiac muscle cell development   • striated muscle tissue development   • striated muscle cell development   • muscle cell development   • cardiac cell development   • muscle tissue development   • cardiac muscle tissue development   • cardiac muscle cell differentiation   • cardiocyte differentiation   • heart process   • circulatory system process   • cardiac muscle contraction   • heart contraction   • muscle contraction   • muscle system process   • blood circulation   • striated muscle contraction   • pyrimidine-containing compound metabolic process   • nucleobase biosynthetic process   • pyrimidine nucleobase biosynthetic process   • pyrimidine nucleobase metabolic process   • nucleobase metabolic process   • 'de novo' pyrimidine nucleobase biosynthetic process   • pyrimidine-containing compound biosynthetic process   • defense response   • inflammatory response   • signal transduction by p53 class mediator   • regulation of signal transduction by p53 class mediator   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • cellular response to endogenous stimulus   • response to hormone   • response to insulin   • cellular response to insulin stimulus   • cellular response to hormone stimulus   • protein localization   • regulation of localization   • cellular localization   • regulation of protein localization   • regulation of protein localization to nucleus   • protein localization to nucleus   • negative regulation of protein localization to nucleus   • localization   • regulation of cellular localization   • cellular macromolecule localization   • macromolecule localization   • protein localization to organelle   • negative regulation of protein localization   • regulation of transcription of nucleolar large rRNA by RNA polymerase I   • positive regulation of DNA-templated transcription   • RNA metabolic process   • RNA biosynthetic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • regulation of RNA metabolic process   • transcription by RNA polymerase I   • rRNA transcription   • rRNA metabolic process   • positive regulation of transcription by RNA polymerase I   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase I   • nucleolar large rRNA transcription by RNA polymerase I   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I   • regulation of DNA-templated transcription   • cell projection organization   • plasma membrane bounded cell projection assembly   • regulation of lamellipodium assembly   • regulation of lamellipodium organization   • positive regulation of cell projection organization   • lamellipodium assembly   • plasma membrane bounded cell projection organization   • regulation of cell projection organization   • regulation of cell projection assembly   • positive regulation of lamellipodium assembly   • positive regulation of lamellipodium organization   • regulation of plasma membrane bounded cell projection assembly   • lamellipodium organization   • cell projection assembly   • regulation of plasma membrane bounded cell projection organization   • positive regulation of plasma membrane bounded cell projection assembly   • regulation of actin filament bundle assembly   • positive regulation of actin filament bundle assembly   • actin filament bundle organization   • positive regulation of stress fiber assembly   • stress fiber assembly   • actomyosin structure organization   • regulation of stress fiber assembly   • contractile actin filament bundle assembly   • regulation of actomyosin structure organization   • actin filament bundle assembly   • negative regulation of cell size   • DNA damage response   • protein destabilization   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • response to hypoxia   • response to oxygen levels   • regulation of amide metabolic process   • regulation of pentose-phosphate shunt   • pentose-phosphate shunt   • positive regulation of pentose-phosphate shunt   • glucose 6-phosphate metabolic process   • regulation of NADP metabolic process   • amide metabolic process   • NADP metabolic process   • NADPH regeneration   • heart morphogenesis   • animal organ morphogenesis   • TORC2 signaling   • ruffle organization   • regulation of leukocyte activation   • regulation of cell activation   • positive regulation of leukocyte cell-cell adhesion   • lymphocyte activation   • leukocyte cell-cell adhesion   • leukocyte activation   • positive regulation of cell-cell adhesion   • positive regulation of lymphocyte activation   • positive regulation of cell activation   • cell adhesion   • cell-cell adhesion   • T cell activation   • positive regulation of leukocyte activation   • regulation of cell-cell adhesion   • positive regulation of immune system process   • positive regulation of T cell activation   • positive regulation of cell adhesion   • regulation of cell adhesion   • cell activation   • regulation of T cell activation   • lymphocyte costimulation   • regulation of leukocyte cell-cell adhesion   • T cell costimulation   • regulation of lymphocyte activation   • cellular response to amino acid starvation   • response to amino acid starvation   • cellular response to heat   • regulation of cellular response to heat   • regulation of cellular response to stress   • regulation of response to stress   • negative regulation of lysosome organization   • negative regulation of cellular component organization   • negative regulation of organelle organization   • regulation of myelination   • nervous system development   • regulation of nervous system development   • myelination   • axon ensheathment   • ensheathment of neurons   • neurogenesis   • central nervous system development   • gliogenesis   • oligodendrocyte differentiation   • glial cell differentiation   • proteolysis involved in protein catabolic process   • macromolecule catabolic process   • regulation of ubiquitin-dependent protein catabolic process   • positive regulation of ubiquitin-dependent protein catabolic process   • regulation of proteolysis   • regulation of proteolysis involved in protein catabolic process   • modification-dependent macromolecule catabolic process   • proteolysis   • protein catabolic process   • positive regulation of proteolysis involved in protein catabolic process   • modification-dependent protein catabolic process   • positive regulation of proteolysis   • ubiquitin-dependent protein catabolic process   • cellular response to leucine starvation   • negative regulation of macroautophagy   • positive regulation of cytoplasmic translational initiation   • regulation of cytoplasmic translational initiation   • cytoplasmic translation   • cytoplasmic translational initiation   • regulation of cytoplasmic translation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • regulation of response to wounding   • positive regulation of response to stimulus   • response to wounding   • regulation of wound healing, spreading of epidermal cells   • positive regulation of response to wounding   • wound healing   • epithelium development   • positive regulation of wound healing, spreading of epidermal cells   • morphogenesis of an epithelium   • epiboly involved in wound healing   • morphogenesis of an epithelial sheet   • wound healing, spreading of epidermal cells   • tissue morphogenesis   • positive regulation of wound healing   • regulation of wound healing   • epiboly   • wound healing, spreading of cells   • regulation of lipid metabolic process   • lipid biosynthetic process   • positive regulation of lipid biosynthetic process   • positive regulation of lipid metabolic process   • regulation of lipid biosynthetic process   • lipid metabolic process   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • energy derivation by oxidation of organic compounds   • energy reserve metabolic process   • action potential   • transmission of nerve impulse   • neuronal action potential   • regulation of membrane potential   • rhythmic behavior   • regulation of behavior   • circadian behavior   • locomotory behavior   • regulation of locomotor rhythm   • locomotor rhythm   • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains   • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment   • T-helper 1 cell lineage commitment   • mononuclear cell differentiation   • lymphocyte differentiation   • cell activation involved in immune response   • CD4-positive, alpha-beta T cell differentiation   • CD4-positive, alpha-beta T cell differentiation involved in immune response   • alpha-beta T cell differentiation involved in immune response   • alpha-beta T cell differentiation   • T cell activation involved in immune response   • alpha-beta T cell activation involved in immune response   • CD4-positive, alpha-beta T cell activation   • leukocyte activation involved in immune response   • alpha-beta T cell activation   • T cell differentiation   • CD4-positive, alpha-beta T cell lineage commitment   • lymphocyte activation involved in immune response   • T-helper cell differentiation   • immune response   • alpha-beta T cell lineage commitment   • T cell differentiation involved in immune response   • T-helper 1 type immune response   • T-helper cell lineage commitment   • T cell lineage commitment   • adaptive immune response   • immune effector process   • positive T cell selection   • T-helper 1 cell differentiation   • T cell selection   • cell fate commitment   • positive regulation of transcription by RNA polymerase III   • transcription by RNA polymerase III   • regulation of transcription by RNA polymerase III   • positive regulation of nervous system development   • regulation of neurogenesis   • regulation of gliogenesis   • positive regulation of gliogenesis   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • regulation of oligodendrocyte differentiation   • post-embryonic development   • regulation of membrane permeability   • negative regulation of amino acid transport   • nitrogen compound transport   • negative regulation of amine transport   • transport   • regulation of glutamate secretion   • negative regulation of transport   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • negative regulation of glutamate secretion   • regulation of amino acid transport   • glutamate secretion   • negative regulation of secretion by cell   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • negative regulation of organic acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • regulation of amine transport   • neuron projection development   • axon development   • generation of neurons   • neuron differentiation   • neuron development   • glycosylation   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • sensory perception   • sensory perception of sound   • sensory perception of mechanical stimulus   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • cell-cell signaling   • chemical synaptic transmission   • modulation of chemical synaptic transmission   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • regulation of trans-synaptic signaling   • organelle envelope   • nuclear envelope   • nucleus   • Golgi membrane   • Golgi apparatus   • TORC1 complex   • TOR complex   • intracellular protein-containing complex   • intracellular vesicle   • phagocytic vesicle   • cytoplasmic vesicle   • vesicle   • endocytic vesicle   • lytic vacuole   • vacuole   • lysosome   • vacuolar membrane   • lytic vacuole membrane   • lysosomal membrane   • mitochondrial membrane   • mitochondrion   • organelle outer membrane   • mitochondrial envelope   • mitochondrial outer membrane   • outer membrane   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • TORC2 complex   • protein kinase complex   • transferase complex, transferring phosphorus-containing groups   • catalytic complex   • serine/threonine protein kinase complex   • transferase complex   • nuclear body   • PML body   • presynaptic active zone   • cell cortex   • receptor complex   • dendritic shaft   • neuron to neuron synapse   • asymmetric synapse
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7EPD_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLSR 
GADGSRHIC GDAPTAITG VIGGSYSDV SIQVANLLR LFQIPQISY 
ASTSAKLSD KSRYDYFAR TVPPDFFQA KAMAEILRF FNWTYVSTV 
ASEGDYGET GIEAFELEA RARNICVAT SEKVGRAMS RAAFEGVVR 
ALLQKPSAR VAVLFTRSE DARELLAAS QRLNASFTW VASDGWGAL 
ESVVAGSEG AAEGAITIE LASYPISDF ASYFQSLDP WNNSRNPWF 
REFWEQRFR CSFRQRDCA AHSLRAVPF EQESKIMFV VNAVYAMAH 
ALHNMHRAL CPNTTRLCD AMRPVNGRR LYKDFVLNV KFDAPFRPA 
DTHNEVRFD RFGDGIGRY NIFTYLRAG SGRYRYQKV GYWAEGLTL 
DTSLIPWAS PSAGPLPAS RCSEPCLQN EVKSVQPGE VCCWLCIPC 
QPYEYRLDE FTCADCGLG YWPNASLTG CFELPQEYI RWGDAWAVG 
PVTIACLGA LATLFVLGV FVRHNATPV VKASGRELC YILLGGVFL 
CYCMTFIFI AKPSTAVCT LRRLGLGTA FSVCYSALL TKTYRIARI 
FGSPASQVA ICLALISGQ LLIVVAWLV VEAPGTGKE TAPERREVV 
TLRCNHRDA SMLGSLAYN VLLIALCTL YAFKTRKCP ENFNEAKFI 
GFTMYTTCI IWLAFLPIF YVTSSDYRV QTTTMCVSV SLSGSVVLG 
CLFAPKLYI ILF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14831
Sequence
>7EPD_Chain_S
HSIRIEGDV TLGGLFPVH AKGPSGVPC GDIKRENGI HRLEAMLYA 
LDQINSDPN LLPNVTLGA RILDTCSRD TYALEQSLT FVQALIQKD 
TSDVRCFVK PEKVVGVIG ASGSSVSIM VANILRLFQ IPQISYAST 
APELSDDRR YDFFSRVVP PDSFQAQAM VDIVKALGW NYVSTLASE 
GSYGEKGVE SFTQISKEA GGLCIAQSV RIPQERKDR TIDFDRIIK 
QLLDTPNSR AVVIFANDE DIKQILAAA KRADQVGHF LWVGSDSWG 
SKINPLHQH EDIAEGAIT IQPKRATVE GFDAYFTSR TLENNRRNV 
WFAEYWEEN FNCKLTISG SKKEDTDRK CTGQERIGK DSNYEQEGK 
VQFVIDAVY AMAHALHHM NKDLCADYR GVCPEMEQA GGKKLLKYI 
RNVNFNGSA GTPVMFNKN GDAPGRYDI FQYQTTNTS NPGYRLIGQ 
WTDELQLNI EDMQWGKGV REIPASVCT LPCKPGQRK KTQKGTPCC 
WTCEPCDGY QYQFDEMTC QHCPYDQRP NENRTGCQD IPIIKLEWH 
SPWAVIPVF LAMLGIIAT IFVMATFIR YNDTPIVRA SGRELSYVL 
LTGIFLCYI ITFLMIAKP DVAVCSFRR VFLGLGMCI SYAALLTKT 
NRIYRIFEQ SPTSQLAIT SSLISVQLL GVFIWFIVD PPNIIIDYD 
EHKTMNPEQ ARGVLKCDI TDLQIICSL GYSILLMVT CTVYAFKTR 
GVPENFNEA KYIGFTMYT TCIVWLAFI PIFFGTAQS AEKLYIQTT 
TLTISMNLS ASVALGMLY MPKVYIIIF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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