Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L26 4.282525
2R:R:L34 4.0054227
3R:R:F38 8.09428
4R:R:P39 4.952525
5R:R:V40 5.34833626
6R:R:H41 8.578528
7R:R:V53 5.735423
8R:R:R61 9.925424
9R:R:L62 3.87525
10R:R:E63 5.15728
11R:R:R71 10.89754347
12R:R:I72 4.1745359
13R:R:L78 5.2765357
14R:R:L79 3.8125409
15R:R:L84 4.1725409
16R:R:H87 6.74754334
17R:R:I88 6.026527
18R:R:L89 5.6485335
19R:R:D90 8.045429
20R:R:C92 7.78428
21R:R:F105 6.84406
22R:R:H119 11.32254373
23R:R:V139 5.6275437
24R:R:I140 4.414227
25R:R:N153 6.89405
26R:R:L154 3.7325435
27R:R:L155 5.0725436
28R:R:R156 8.1175435
29R:R:L157 4.944535
30R:R:F158 10.004536
31R:R:Y165 7.81728
32R:R:L172 5.96647
33R:R:Y178 9.884546
34R:R:Y180 6.454386
35R:R:F181 9.33449
36R:R:R183 9.254549
37R:R:P186 5.465168
38R:R:P187 8.5075447
39R:R:F189 5.77543
40R:R:F190 7.8675445
41R:R:Q191 6.0485168
42R:R:F202 10.2525468
43R:R:W204 11.028569
44R:R:Y206 3.90258109
45R:R:T209 5.6175456
46R:R:Y216 5.5175457
47R:R:I221 4.162555
48R:R:F224 5.124557
49R:R:E239 6.654295
50R:R:M245 5.06453
51R:R:V265 8.01468
52R:R:V267 6.68456
53R:R:W291 5.07833687
54R:R:V292 4.6225407
55R:R:W297 5.25714786
56R:R:I315 3.5275405
57R:R:T316 3.9075487
58R:R:I317 4.09754166
59R:R:L319 4.9645164
60R:R:Y322 7.3754183
61R:R:F327 8.42528
62R:R:F331 5.018526
63R:R:L334 6.92525
64R:R:N342 5.40667627
65R:R:W344 5.528524
66R:R:F345 4.308524
67R:R:W349 8.026528
68R:R:Q351 5.41423
69R:R:F353 9.8375427
70R:R:F372 5.355625
71R:R:Q374 4.854525
72R:R:I378 8.98427
73R:R:F380 6.818336166
74R:R:Y386 9.0925406
75R:R:M388 4.864226
76R:R:M395 5.785405
77R:R:C400 3.8725403
78R:R:L406 6.8525282
79R:R:Y419 5.675605
80R:R:F422 4.2554414
81R:R:F428 8.104508
82R:R:R433 6.5925183
83R:R:P434 4.28254185
84R:R:N439 6.49254185
85R:R:F443 4.15408
86R:R:D448 9.635447
87R:R:R452 5.295404
88R:R:Y453 7.545168
89R:R:I455 4.08408
90R:R:F456 4.29485
91R:R:Y468 6.592584
92R:R:V471 3.315667
93R:R:W474 6.1375406
94R:R:L478 3.896566
95R:R:I485 5.86407
96R:R:W487 6.23833667
97R:R:C500 4.484109
98R:R:C518 4.54254109
99R:R:C525 4.195499
100R:R:Q526 6.2675495
101R:R:Y528 10.854598
102R:R:D533 6.184307
103R:R:F535 5.60254302
104R:R:L542 3.1875494
105R:R:L556 3.0675408
106R:R:W563 7.228505
107R:R:T573 1.655401
108R:R:V588 6.0065316
109R:R:H592 10.654314
110R:R:T595 3.4875409
111R:R:R603 4.34409
112R:R:L609 2.23408
113R:R:F614 12.53754195
114R:R:T641 1.9575406
115R:R:Y647 8.08406
116R:R:L651 5.554209
117R:R:I687 3.3254457
118R:R:Q690 3.9085459
119R:R:W697 10.8975407
120R:R:R720 12.9554236
121R:R:M766 4.5465209
122R:R:T768 3.5225408
123R:R:R788 7.844235
124R:R:Q790 11.76254477
125R:R:L806 4.1925198
126R:R:F810 11.365409
127R:R:K813 12.464319
128R:R:I817 13.224319
129S:S:I43 5.1175404
130S:S:L51 4.615417
131S:S:F55 6.20333619
132S:S:V57 6.90167615
133S:S:H58 7.445418
134S:S:C67 5.08418
135S:S:K71 7.75167615
136S:S:I76 5.29167617
137S:S:R78 5.79571714
138S:S:L79 5.086515
139S:S:E80 5.782518
140S:S:M82 5.642518
141S:S:Y84 9.415407
142S:S:I89 6.73754499
143S:S:L95 4.7125497
144S:S:L96 3.605409
145S:S:P97 3.29408
146S:S:L101 3.50667609
147S:S:R104 7.8875435
148S:S:I105 4.864517
149S:S:L106 4.805404
150S:S:D107 6.6425418
151S:S:Y114 10.485404
152S:S:L120 4.9525436
153S:S:F122 5.28636
154S:S:V123 6.8225435
155S:S:F144 11.10754371
156S:S:V151 3.4525404
157S:S:V153 5.9425436
158S:S:I154 4.23167617
159S:S:A156 3.9175435
160S:S:S157 5.9225415
161S:S:S162 4.62438
162S:S:V165 5.315436
163S:S:N167 7.882535
164S:S:L169 4.645436
165S:S:L171 4.7725435
166S:S:Q176 6.1638
167S:S:I177 3.03516
168S:S:S178 4.62438
169S:S:Y179 9.736517
170S:S:L186 4.38438
171S:S:R191 9.525435
172S:S:Y192 7.52636
173S:S:F194 8.13254507
174S:S:F195 4.31571738
175S:S:R197 5.954539
176S:S:P200 5.415417
177S:S:P201 8.755438
178S:S:D202 5.3175409
179S:S:Q205 6.28667619
180S:S:M209 3.7625417
181S:S:K214 2.8125255
182S:S:W218 7.15609
183S:S:Y220 5.4545119
184S:S:S222 3.914128
185S:S:S226 4.534266
186S:S:L248 3.31754257
187S:S:Q252 6.36754126
188S:S:V254 5.61754124
189S:S:I256 4.753336265
190S:S:Q258 9.5354265
191S:S:F267 5.4625403
192S:S:Q273 6.425123
193S:S:L274 4.794127
194S:S:V284 4.9825406
195S:S:F286 7.23417
196S:S:D289 7.5654133
197S:S:D291 5.308336264
198S:S:K300 5.7454143
199S:S:Q304 4.8975404
200S:S:W310 6.78754146
201S:S:D314 7.05418
202S:S:W316 5.4654138
203S:S:P322 5.3885133
204S:S:I329 5.384144
205S:S:I336 4.605416
206S:S:F346 6.42254248
207S:S:N361 6.604518
208S:S:W363 5.68857715
209S:S:F364 7.11167615
210S:S:Y367 8.0375416
211S:S:W368 6.5425408
212S:S:L376 3.25403
213S:S:Q404 7.3925245
214S:S:K407 4.9375414
215S:S:F410 8.2775417
216S:S:V415 4.65419
217S:S:M418 4.4525416
218S:S:M425 4.42406
219S:S:C437 4.62407
220S:S:Y451 4.05405
221S:S:I452 2.985417
222S:S:F457 5.86833609
223S:S:D472 8.5475438
224S:S:Y477 6.71833619
225S:S:D478 6.21754217
226S:S:I479 4.785418
227S:S:F480 5.63254215
228S:S:Q481 5.7225408
229S:S:Y482 6.204506
230S:S:Y492 6.034215
231S:S:I495 4.77618
232S:S:W498 7.46415
233S:S:L502 4.1575416
234S:S:W511 4.4954528
235S:S:P519 5.774118
236S:S:Y553 6.0765277
237S:S:Q567 3.4645275
238S:S:R568 8.702577
239S:S:N570 4.442577
240S:S:C576 4.9154279
241S:S:I579 6.4925478
242S:S:T618 3.55754579
243S:S:R626 4.8475408
244S:S:L628 8.175408
245S:S:Y640 4.396676178
246S:S:T643 4.4825407
247S:S:K649 9.6454325
248S:S:P650 3.7575409
249S:S:R658 8.908508
250S:S:M666 5.0754158
251S:S:Y670 9.5345156
252S:S:P726 4.015408
253S:S:H735 7.9475
254S:S:M738 5.51474
255S:S:K748 2.9275406
256S:S:I751 3.1375406
257S:S:Q755 4.1175407
258S:S:M767 9.47754158
259S:S:Y773 5.73407
260S:S:T793 4.60754159
261S:S:M794 5.58754589
262S:S:T796 3.19754158
263S:S:W801 9.326676159
264S:S:T823 1.785408
265S:S:L837 4.76178
266S:S:Y841 13.705409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L89 R:R:Q101 11.69157.99YesNo055
2R:R:H97 R:R:Q101 11.54413.6NoNo035
3R:R:C92 R:R:H97 11.220810.32YesNo083
4R:R:F380 R:R:T184 32.44273.89YesNo069
5R:R:F380 R:R:K377 25.34298.69YesNo063
6R:R:K377 R:R:R61 15.751812.38NoYes034
7R:R:F105 R:R:L89 12.8074.87YesYes065
8R:R:F38 R:R:M65 11.59249.95YesNo289
9R:R:F38 R:R:Y165 12.005715.47YesYes288
10R:R:F105 R:R:V139 13.65569.18YesYes067
11R:R:L155 R:R:V139 13.32195.96YesYes367
12R:R:L154 R:R:L155 14.30624.15YesYes356
13R:R:F158 R:R:L154 12.66243.65YesYes365
14R:R:F158 R:R:L157 14.52758.53YesYes365
15R:R:L157 S:S:I168 10.92714.28YesNo056
16S:S:I168 S:S:S119 10.83824.64NoNo065
17S:S:S119 S:S:V165 10.84378.08NoYes056
18S:S:L54 S:S:V165 10.85272.98NoYes086
19S:S:Q118 S:S:Y114 10.124324.8NoYes064
20R:R:L172 R:R:Y178 73.54275.86YesYes476
21R:R:N153 S:S:R170 23.69614.82YesNo055
22R:R:D179 R:R:R156 40.53138.34NoYes075
23R:R:D179 R:R:Y180 40.45283.45NoYes076
24R:R:Y180 R:R:Y419 40.28553.97YesYes065
25R:R:A182 R:R:Y419 37.28952.67NoYes065
26R:R:A182 R:R:F443 37.17746.93NoYes068
27R:R:F443 R:R:T184 29.98353.89YesNo089
28R:R:L157 S:S:N167 12.12444.12YesYes355
29R:R:D295 R:R:L319 10.82518.14NoYes084
30R:R:F380 R:R:L319 26.00824.87YesYes1664
31R:R:Q191 R:R:Y453 10.848111.27YesYes1688
32R:R:L319 R:R:Y453 18.02727.03YesYes1648
33R:R:P186 R:R:Y453 16.45139.74YesYes1688
34R:R:F380 R:R:P186 16.59432.89YesYes1668
35R:R:P187 R:R:R183 37.325911.53YesYes479
36R:R:R177 S:S:R191 51.81059.6NoYes055
37R:R:R177 R:R:Y178 51.827313.38NoYes056
38R:R:D448 R:R:R183 37.256415.48YesYes479
39R:R:F190 R:R:P187 37.00168.67YesYes457
40R:R:D448 R:R:F190 37.11598.36YesYes475
41R:R:F190 R:R:K193 74.23463.72YesNo053
42R:R:K193 R:R:W474 73.51564.64NoYes036
43R:R:W474 R:R:Y453 35.65794.82YesYes068
44R:R:I317 R:R:Y453 36.69964.84YesYes1668
45R:R:F224 R:R:M195 17.35164.98YesNo077
46R:R:I317 R:R:M195 27.72732.92YesNo067
47R:R:M195 R:R:V292 10.2196.09NoYes077
48R:R:L478 R:R:W474 55.51723.42YesYes066
49R:R:I317 R:R:I455 10.41555.89YesYes068
50R:R:I315 R:R:I455 10.07742.94YesYes058
51R:R:F201 R:R:L478 52.58373.65NoYes656
52R:R:F201 R:R:F202 52.44087.5NoYes658
53R:R:F202 R:R:W204 51.571421.05YesYes689
54R:R:S498 R:R:W204 69.32654.94NoYes699
55R:R:A263 R:R:S498 69.72493.42NoNo079
56R:R:A263 R:R:Y206 69.50382.67NoYes079
57R:R:C500 R:R:Y206 66.60464.03YesYes1099
58R:R:F250 R:R:M245 21.39627.46NoYes033
59R:R:D274 R:R:F250 10.43617.17NoNo043
60R:R:I221 R:R:K240 15.43682.91YesNo554
61R:R:E213 R:R:K240 15.07822.7NoNo564
62R:R:E213 R:R:M245 14.65192.71NoYes563
63R:R:E277 R:R:F250 10.43613.5NoNo023
64R:R:D295 R:R:E318 12.61153.9NoNo086
65R:R:F428 R:R:H390 13.026920.36YesNo086
66R:R:A387 R:R:F428 15.78814.16NoYes088
67R:R:A387 R:R:F443 16.00682.77NoYes088
68R:R:C500 R:R:S501 65.93873.44YesNo1098
69R:R:S501 R:R:W520 65.74424.94NoNo087
70R:R:C504 R:R:C522 64.6325.46NoNo099
71R:R:C522 R:R:K510 64.85461.62NoNo097
72R:R:K510 R:R:W520 65.07718.12NoNo077
73R:R:C504 R:R:N507 64.40936.3NoNo099
74R:R:E508 R:R:N507 63.963917.09NoNo069
75R:R:C525 R:R:E508 63.74113.04YesNo096
76R:R:C525 R:R:E529 63.06333.04YesNo998
77R:R:E529 R:R:Q526 62.85798.92NoYes985
78R:R:Q526 R:R:Y528 62.17077.89YesYes958
79R:R:L542 R:R:Y528 59.8764.69YesYes948
80R:R:G543 R:R:L556 58.98961.71NoYes058
81R:R:G543 R:R:L542 59.21341.71NoYes054
82R:R:L556 R:R:V716 58.16542.98YesNo085
83R:R:K707 R:R:V716 57.71623.04NoNo025
84R:R:K707 R:R:T718 57.491510.51NoNo026
85R:R:L639 R:R:R635 10.29338.5NoNo088
86R:R:L639 R:R:M619 10.531219.79NoNo087
87R:R:G638 R:R:M619 47.08463.49NoNo067
88R:R:G638 R:R:T641 47.31231.82NoYes066
89R:R:L637 R:R:T641 50.722.95NoYes046
90R:R:L637 R:R:V694 50.94662.98NoNo046
91R:R:R636 R:R:V694 51.39973.92NoNo086
92R:R:M728 R:R:R636 51.626219.85NoNo078
93R:R:H723 R:R:M728 52.75765.25NoNo057
94R:R:C632 R:R:H723 52.97634.42NoNo4495
95R:R:C632 R:R:T633 53.43563.38NoNo095
96R:R:P703 R:R:T633 53.88731.75NoNo095
97R:R:P703 R:R:T629 54.33871.75NoNo093
98R:R:G704 R:R:T629 55.24081.82NoNo043
99R:R:G704 R:R:T705 56.3671.82NoNo044
100R:R:T705 R:R:T718 56.5921.57NoNo046
101R:R:L609 R:R:V613 14.53682.98YesNo088
102R:R:C646 R:R:L609 15.24551.59NoYes068
103R:R:C646 R:R:Y647 15.48162.69NoYes066
104R:R:W773 R:R:Y647 27.166912.54NoYes096
105R:R:F643 R:R:W773 34.692615.03NoNo089
106R:R:F643 R:R:V798 34.92385.24NoNo088
107R:R:T620 R:R:V798 36.30963.17NoNo078
108R:R:M619 R:R:T620 36.77113.01NoNo077
109R:R:L806 R:R:V613 12.87044.47YesNo1988
110R:R:F810 R:R:L806 11.93322.44YesYes098
111R:R:I739 R:R:Y647 11.211313.3NoYes086
112R:R:I739 R:R:L651 10.73625.71NoYes2089
113R:R:G763 R:R:M766 12.83763.49NoYes099
114R:R:F747 R:R:G763 12.1254.52NoNo089
115R:R:F747 R:R:R750 10.69914.97NoNo4689
116S:S:I163 S:S:N167 20.92934.25NoYes355
117S:S:I163 S:S:L186 20.88444.28NoYes358
118S:S:L186 S:S:R197 90.75046.07YesYes389
119S:S:P201 S:S:R197 92.338812.97YesYes389
120S:S:F204 S:S:P201 92.4117.22NoYes058
121S:S:F204 S:S:P200 92.49844.33NoYes057
122S:S:P200 S:S:Y477 1009.74YesYes179
123S:S:D314 S:S:Y477 32.71494.6YesYes189
124S:S:D314 S:S:Q205 32.921714.36YesYes189
125S:S:F286 S:S:Q205 63.55298.2YesYes179
126S:S:F286 S:S:V284 63.44733.93YesYes076
127S:S:V221 S:S:V284 62.53874.81NoYes076
128S:S:A282 S:S:V221 60.26363.39NoNo087
129S:S:A282 S:S:W218 60.13116.48NoYes089
130S:S:P519 S:S:W218 89.61689.46YesYes089
131S:S:P519 S:S:Y220 78.8392.78YesYes1189
132S:S:C249 S:S:Y220 70.2232.69NoYes1199
133S:S:C249 S:S:C541 70.01897.28NoNo099
134S:S:C541 S:S:C542 69.80461.82NoNo099
135S:S:C523 S:S:C542 69.16127.28NoNo099
136S:S:C523 S:S:T524 68.94661.69NoNo098
137S:S:C545 S:S:T524 67.65785.07NoNo098
138S:S:C527 S:S:C545 67.44277.28NoNo099
139S:S:C527 S:S:R532 67.22764.18NoNo096
140S:S:P529 S:S:R532 66.79725.76NoNo056
141S:S:P529 S:S:Q531 65.935612.63NoNo056
142S:S:Q531 S:S:R573 65.50442.34NoNo066
143S:S:G550 S:S:R573 63.77713NoNo056
144S:S:D549 S:S:G550 63.56095.03NoNo055
145S:S:D549 S:S:Y551 63.34462.3NoNo057
146S:S:T737 S:S:Y551 63.12832.5NoNo057
147S:S:R568 S:S:T737 62.911818.11YesNo075
148S:S:E741 S:S:R568 60.96139.3NoYes737
149S:S:E741 S:S:I579 54.64722.73NoYes738
150S:S:I579 S:S:Q742 54.42149.61YesNo084
151S:S:I582 S:S:Q742 54.20245.49NoNo054
152S:S:I582 S:S:V746 53.98343.07NoNo056
153S:S:L818 S:S:V746 53.76424.47NoNo066
154S:S:K748 S:S:L818 35.03074.23YesNo066
155S:S:I751 S:S:K748 28.76694.36YesYes066
156S:S:I751 S:S:I756 27.43682.94YesNo067
157S:S:I756 S:S:L760 26.98522.85NoNo5977
158S:S:L760 S:S:S763 26.76833NoNo077
159S:S:S763 S:S:Y670 26.10022.54NoYes076
160S:S:N167 S:S:Y192 21.04118.14YesYes356
161S:S:L186 S:S:Y192 71.38933.52YesYes386
162S:S:I336 S:S:Y477 64.13398.46YesYes169
163S:S:I336 S:S:Q205 32.67772.74YesYes169
164S:S:I336 S:S:I479 31.47124.42YesYes168
165S:S:I479 S:S:I495 31.28615.89YesYes188
166S:S:I495 S:S:Q481 30.78198.23YesYes088
167S:S:Q481 S:S:R516 30.60033.5YesNo083
168S:S:L216 S:S:R516 30.49214.86NoNo083
169S:S:L216 S:S:W218 30.430610.25NoYes089
170S:S:C67 S:S:Y114 10.77394.03YesYes084
171S:S:D193 S:S:R170 27.33565.96NoNo075
172S:S:D193 S:S:F194 27.192410.75NoYes077
173S:S:F194 S:S:L449 26.34637.31YesNo076
174S:S:L449 S:S:P175 15.29926.57NoNo069
175S:S:G152 S:S:P175 14.01094.06NoNo089
176S:S:G152 S:S:M418 14.00433.49NoYes086
177S:S:I154 S:S:M418 10.70942.92YesYes176
178S:S:I154 S:S:M82 21.61827.29YesYes178
179S:S:I105 S:S:M82 13.64034.37YesYes178
180S:S:L449 S:S:R453 11.0023.64NoNo065
181S:S:R453 S:S:S196 10.9815.27NoNo056
182S:S:I177 S:S:S196 10.84433.1YesNo166
183S:S:I154 S:S:I177 11.70042.94YesYes176
184S:S:F55 S:S:M82 10.76666.22YesYes198
185S:S:P200 S:S:V199 14.32423.53YesNo177
186S:S:K407 S:S:V199 12.07554.55YesNo147
187S:S:K407 S:S:R78 11.72673.71YesYes144
188S:S:F55 S:S:L79 11.40267.31YesYes195
189S:S:E80 S:S:L79 14.59327.95YesYes185
190S:S:E80 S:S:F364 14.66875.83YesYes185
191S:S:P519 S:S:R281 10.945.76YesNo1185
192S:S:H307 S:S:R281 10.71034.51NoNo045
193S:S:D328 S:S:H307 10.47925.04NoNo034
194S:S:D328 S:S:K300 10.0164.15NoYes1433
195S:S:F364 S:S:W368 18.24476.01YesYes058
196S:S:L355 S:S:W368 15.10299.11NoYes058
197S:S:L355 S:S:L376 14.47442.77NoYes053
198S:S:L376 S:S:T391 11.95962.95YesNo035
199S:S:K817 S:S:L818 18.69492.82NoNo066
200S:S:K817 S:S:S814 17.11013.06NoNo068
201S:S:E816 S:S:S814 16.88357.19NoNo068
202S:S:E816 S:S:I820 16.43558.2NoNo065
203S:S:I820 S:S:T824 16.21321.52NoNo058
204S:S:T823 S:S:T824 15.76861.57YesNo088
205S:S:T823 S:S:T826 11.75831.57YesNo087
206S:S:T643 S:S:T826 11.53511.57YesNo077
207S:S:M666 S:S:Y670 12.36053.59YesYes1586
208S:S:C639 S:S:M666 11.98731.62NoYes078
209R:R:R156 S:S:N167 31.685614.46YesYes355
210R:R:N153 R:R:Y178 21.941913.96YesYes056
211R:R:L172 R:R:R183 73.24624.86YesYes479
212S:S:R191 S:S:Y192 51.831216.46YesYes356
213S:S:F55 S:S:R78 10.15725.34YesYes194
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EPD
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu2; mGlu7
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.9
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03641-w
Net Summary
Imin 2.67
Number of Linked Nodes 1472
Number of Links 1747
Number of Hubs 266
Number of Links mediated by Hubs 937
Number of Communities 59
Number of Nodes involved in Communities 419
Number of Links involved in Communities 575
Path Summary
Number Of Nodes in MetaPath 214
Number Of Links MetaPath 213
Number of Shortest Paths 6066331
Length Of Smallest Path 3
Average Path Length 49.8436
Length of Longest Path 131
Minimum Path Strength 1.19
Average Path Strength 5.91125
Maximum Path Strength 24.1
Minimum Path Correlation 0.7
Average Path Correlation 0.998826
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 58.0249
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.856
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7EPD_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLSR 
GADGSRHIC GDAPTAITG VIGGSYSDV SIQVANLLR LFQIPQISY 
ASTSAKLSD KSRYDYFAR TVPPDFFQA KAMAEILRF FNWTYVSTV 
ASEGDYGET GIEAFELEA RARNICVAT SEKVGRAMS RAAFEGVVR 
ALLQKPSAR VAVLFTRSE DARELLAAS QRLNASFTW VASDGWGAL 
ESVVAGSEG AAEGAITIE LASYPISDF ASYFQSLDP WNNSRNPWF 
REFWEQRFR CSFRQRDCA AHSLRAVPF EQESKIMFV VNAVYAMAH 
ALHNMHRAL CPNTTRLCD AMRPVNGRR LYKDFVLNV KFDAPFRPA 
DTHNEVRFD RFGDGIGRY NIFTYLRAG SGRYRYQKV GYWAEGLTL 
DTSLIPWAS PSAGPLPAS RCSEPCLQN EVKSVQPGE VCCWLCIPC 
QPYEYRLDE FTCADCGLG YWPNASLTG CFELPQEYI RWGDAWAVG 
PVTIACLGA LATLFVLGV FVRHNATPV VKASGRELC YILLGGVFL 
CYCMTFIFI AKPSTAVCT LRRLGLGTA FSVCYSALL TKTYRIARI 
FGSPASQVA ICLALISGQ LLIVVAWLV VEAPGTGKE TAPERREVV 
TLRCNHRDA SMLGSLAYN VLLIALCTL YAFKTRKCP ENFNEAKFI 
GFTMYTTCI IWLAFLPIF YVTSSDYRV QTTTMCVSV SLSGSVVLG 
CLFAPKLYI ILF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14831
Sequence
>7EPD_Chain_S
HSIRIEGDV TLGGLFPVH AKGPSGVPC GDIKRENGI HRLEAMLYA 
LDQINSDPN LLPNVTLGA RILDTCSRD TYALEQSLT FVQALIQKD 
TSDVRCFVK PEKVVGVIG ASGSSVSIM VANILRLFQ IPQISYAST 
APELSDDRR YDFFSRVVP PDSFQAQAM VDIVKALGW NYVSTLASE 
GSYGEKGVE SFTQISKEA GGLCIAQSV RIPQERKDR TIDFDRIIK 
QLLDTPNSR AVVIFANDE DIKQILAAA KRADQVGHF LWVGSDSWG 
SKINPLHQH EDIAEGAIT IQPKRATVE GFDAYFTSR TLENNRRNV 
WFAEYWEEN FNCKLTISG SKKEDTDRK CTGQERIGK DSNYEQEGK 
VQFVIDAVY AMAHALHHM NKDLCADYR GVCPEMEQA GGKKLLKYI 
RNVNFNGSA GTPVMFNKN GDAPGRYDI FQYQTTNTS NPGYRLIGQ 
WTDELQLNI EDMQWGKGV REIPASVCT LPCKPGQRK KTQKGTPCC 
WTCEPCDGY QYQFDEMTC QHCPYDQRP NENRTGCQD IPIIKLEWH 
SPWAVIPVF LAMLGIIAT IFVMATFIR YNDTPIVRA SGRELSYVL 
LTGIFLCYI ITFLMIAKP DVAVCSFRR VFLGLGMCI SYAALLTKT 
NRIYRIFEQ SPTSQLAIT SSLISVQLL GVFIWFIVD PPNIIIDYD 
EHKTMNPEQ ARGVLKCDI TDLQIICSL GYSILLMVT CTVYAFKTR 
GVPENFNEA KYIGFTMYT TCIVWLAFI PIFFGTAQS AEKLYIQTT 
TLTISMNLS ASVALGMLY MPKVYIIIF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E9GCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/&β;1/&γ;23.52021-06-2310.1038/s41586-021-03495-2
7EPACAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPFCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7MTQCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTRCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/&β;1/&γ;23.22021-07-0710.1038/s41586-021-03680-3
8JCUCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateJ9R-3.32023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD2CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/&β;1/&γ;23.32023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/&β;1/&γ;23.62023-06-2110.1038/s41422-023-00830-2




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