Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?901 8.3511010
2M:M:?901 9.72333910
3R:R:V25 2.99414
4R:R:F38 11.4418
5R:R:P39 4.30333605
6R:R:V40 6.835416
7R:R:H41 6.81718
8R:R:V53 5.3675413
9R:R:H56 7.7525403
10R:R:R57 10.0783614
11R:R:Q60 5.335417
12R:R:R61 7.26125814
13R:R:L62 6.23415
14R:R:E63 5.17125818
15R:R:M65 5.17419
16R:R:F67 10.8175417
17R:R:R71 8.722517
18R:R:I72 7.395419
19R:R:L78 7.5725417
20R:R:L79 4.25409
21R:R:V82 4.775405
22R:R:L84 3.886509
23R:R:H87 6.215414
24R:R:I88 8.165417
25R:R:L89 7.175415
26R:R:D90 8.71419
27R:R:C92 8.905418
28R:R:K94 4.475403
29R:R:D95 8.5225414
30R:R:H97 10.3325413
31R:R:L99 8435
32R:R:Q101 9.425415
33R:R:F105 5.87167616
34R:R:I140 4.5275417
35R:R:S143 5.545414
36R:R:Y144 8.29333613
37R:R:D146 8.89415
38R:R:V147 3.68414
39R:R:S148 4.202517
40R:R:I149 7.7275415
41R:R:N153 8.5225415
42R:R:R156 6.244515
43R:R:F158 7.3325406
44R:R:P161 3.45409
45R:R:I163 5.8875417
46R:R:Y165 9.352518
47R:R:A166 4.0775415
48R:R:T168 5.008517
49R:R:S169 5.4625407
50R:R:K171 6.98413
51R:R:L172 7.00833617
52R:R:R177 10.2675405
53R:R:Y178 9.496516
54R:R:Y180 9.92416
55R:R:F181 8.18519
56R:R:R183 7.75667619
57R:R:T184 5.1375409
58R:R:V185 5.88407
59R:R:P186 4.152518
60R:R:P187 7.262517
61R:R:D188 5.5225418
62R:R:F190 7.12833615
63R:R:Q191 8.494518
64R:R:K193 7.385413
65R:R:M195 5.74407
66R:R:E197 8.442516
67R:R:L199 4.618516
68R:R:R200 3.4075404
69R:R:F202 6.57667618
70R:R:W204 7.696519
71R:R:Y206 6.1425149
72R:R:T209 3.5425406
73R:R:S212 4.4675416
74R:R:Y216 7.70375817
75R:R:I221 4.4825405
76R:R:I233 2.92416
77R:R:V241 4.01416
78R:R:R243 11.0925412
79R:R:M245 4.925413
80R:R:F250 7.042513
81R:R:K260 5.4465144
82R:R:V265 5.0375418
83R:R:V267 6.82416
84R:R:L268 4.3375415
85R:R:F269 6.978517
86R:R:R271 11.345615
87R:R:E273 6.2175411
88R:R:D274 5.36514
89R:R:L278 4.156515
90R:R:L279 5.9925415
91R:R:R284 9.1154153
92R:R:W291 6.11286717
93R:R:D295 5.74714718
94R:R:W297 8.45167616
95R:R:L300 4.696515
96R:R:E308 7.4414
97R:R:L319 6.404514
98R:R:Y322 7.2654173
99R:R:I324 4.366516
100R:R:F327 6.8275818
101R:R:Y330 7.765418
102R:R:F331 5.64616
103R:R:L334 6.804515
104R:R:P336 13.315416
105R:R:N339 5.6775414
106R:R:R341 5.446504
107R:R:N342 6.29167617
108R:R:W344 6.90667614
109R:R:F345 5.81167614
110R:R:F348 7.205406
111R:R:W349 9.54667618
112R:R:F357 9.0725413
113R:R:F372 7.63167615
114R:R:Q374 6.555415
115R:R:K377 5.71513
116R:R:M379 7.495408
117R:R:F380 9.5425406
118R:R:N383 5.2025408
119R:R:Y386 10.276516
120R:R:C400 4.14203
121R:R:L418 4.075407
122R:R:Y419 3.894505
123R:R:F422 6.12143714
124R:R:F428 10.01518
125R:R:P431 10.0225417
126R:R:F432 8.42667614
127R:R:R433 5.054173
128R:R:F443 5.40833618
129R:R:D448 9.3875417
130R:R:Y453 8.23667618
131R:R:I455 4.56408
132R:R:F456 4.77754165
133R:R:Y458 8.148515
134R:R:L459 4.56754216
135R:R:W474 7.67333616
136R:R:L478 6.0225416
137R:R:I485 6.8325417
138R:R:W487 5.66571717
139R:R:A488 4.13411
140R:R:C504 4.13254229
141R:R:K510 7.305427
142R:R:I523 5.5775424
143R:R:Y528 7.26333628
144R:R:E529 7.136528
145R:R:D539 6.3775423
146R:R:W545 3.3375406
147R:R:E559 6.0575496
148R:R:Y560 4.0275406
149R:R:L586 3.3825405
150R:R:H592 3.8825474
151R:R:N593 4.5375475
152R:R:T595 4.2275479
153R:R:V598 3.9725479
154R:R:L605 5.75408
155R:R:Y607 5.9725478
156R:R:L609 4.648508
157R:R:L610 2.8675409
158R:R:V613 3.664138
159R:R:Y617 4.426676138
160R:R:M619 4.855407
161R:R:T620 5.32407
162R:R:P627 4.16599
163R:R:R635 3.99408
164R:R:R636 4.9625408
165R:R:F643 7.954548
166R:R:Y647 9.22167646
167R:R:Q690 7.37754259
168R:R:P703 4.81409
169R:R:K707 5.0925402
170R:R:V717 5.005408
171R:R:Y734 6.9854258
172R:R:Y745 3.545407
173R:R:F756 6.4654249
174R:R:M766 6.36754269
175R:R:W773 10.072549
176R:R:Q790 15.1225407
177R:R:K813 7.0925409
178S:S:L26 5.28615
179S:S:L32 3.564305
180S:S:L34 5.63333617
181S:S:F38 7.154518
182S:S:P39 4.7825415
183S:S:H41 5.29143718
184S:S:K43 5.605413
185S:S:R57 8.89333614
186S:S:Q60 10.1075417
187S:S:R61 7.32333914
188S:S:L62 4.3625415
189S:S:E63 6.05571718
190S:S:M65 5.1719
191S:S:L66 5.444515
192S:S:L69 4.2416
193S:S:R71 7.552517
194S:S:I72 5.37419
195S:S:L78 6.474517
196S:S:V82 5.16254305
197S:S:R83 6.834297
198S:S:H87 6.324104
199S:S:I88 5.19833617
200S:S:L89 9.4454105
201S:S:D90 5.4425419
202S:S:C92 5.955418
203S:S:T96 5.92412
204S:S:H97 7.2775413
205S:S:L99 6.074515
206S:S:F105 7.4245106
207S:S:I140 5.685417
208S:S:S143 6.586514
209S:S:Y144 10.26513
210S:S:D146 5.505415
211S:S:R156 5.81635
212S:S:P161 4.7075409
213S:S:Q162 8.175408
214S:S:Y165 9.01518
215S:S:A166 4.135415
216S:S:S167 4.9225418
217S:S:T168 4.72517
218S:S:L172 6.48517
219S:S:Y178 8.645406
220S:S:Y180 8.16436
221S:S:F181 8.94571719
222S:S:R183 8.13667619
223S:S:V185 5.3475407
224S:S:P186 4.8025418
225S:S:P187 6.652517
226S:S:D188 5.17518
227S:S:F189 5.98413
228S:S:F190 5.21515
229S:S:Q191 10.7375418
230S:S:K193 7.675413
231S:S:E197 7.0325416
232S:S:L199 3.64616
233S:S:R200 3.998504
234S:S:F202 8.096518
235S:S:W204 6.71167619
236S:S:Y206 6.085609
237S:S:S212 4.0675416
238S:S:Y216 9.385617
239S:S:I221 4.485405
240S:S:F224 5.67417
241S:S:R231 5.615614
242S:S:V241 4.976516
243S:S:R243 7.445412
244S:S:M245 7.0225413
245S:S:F250 8.808513
246S:S:E251 6.8154112
247S:S:V265 5.4475418
248S:S:F269 5.22517
249S:S:R271 8.43857715
250S:S:D274 5.888514
251S:S:L279 5.8075415
252S:S:R284 8.694113
253S:S:F289 6.2775416
254S:S:W291 7.75429717
255S:S:D295 5.69833618
256S:S:W297 6.35667916
257S:S:L300 4.9075415
258S:S:V303 4.1225414
259S:S:I317 5.5075416
260S:S:E318 5.234516
261S:S:L319 5.4225414
262S:S:F327 7.93667618
263S:S:F331 7.54667616
264S:S:P336 10.37416
265S:S:W337 5.344513
266S:S:N339 5.468514
267S:S:R341 7.298504
268S:S:W344 8.58167614
269S:S:F345 7.33429714
270S:S:F348 8.0975406
271S:S:W349 8.61286718
272S:S:F353 13.45417
273S:S:F357 7.55167613
274S:S:F372 7.665615
275S:S:Q374 7.124515
276S:S:E375 8.145415
277S:S:K377 5.296513
278S:S:I378 7.004517
279S:S:M379 8.36418
280S:S:F380 6.882516
281S:S:V381 5.3325417
282S:S:V382 4.39418
283S:S:N383 6.66408
284S:S:V385 4.3675419
285S:S:Y386 6.43143716
286S:S:M395 3.924315
287S:S:L406 4.9154302
288S:S:M410 5.2275402
289S:S:N414 5.57404
290S:S:L418 5.55754317
291S:S:Y419 5.41635
292S:S:D421 3.7825405
293S:S:F422 6.385634
294S:S:P431 5.635417
295S:S:F432 6.044514
296S:S:R433 4.606503
297S:S:F443 7.015438
298S:S:D448 7.57167617
299S:S:R452 4.4475404
300S:S:Y453 6.15429718
301S:S:I455 4.0575418
302S:S:F456 6.414515
303S:S:T457 4.9725418
304S:S:Y458 10.634515
305S:S:R467 5.3275402
306S:S:Y468 8.658514
307S:S:V471 4.655617
308S:S:W474 7.365616
309S:S:L478 4.9575416
310S:S:L480 4.23516
311S:S:I485 6.42617
312S:S:W487 6.96167617
313S:S:P514 3.75405
314S:S:E516 6.97404
315S:S:Y528 8.0665358
316S:S:C540 4.9225489
317S:S:L586 2.21405
318S:S:F589 3.82667659
319S:S:Y617 7.5375408
320S:S:R635 6.99508
321S:S:R636 6.68429768
322S:S:L637 4.10754364
323S:S:F643 7.205408
324S:S:Y647 15.8825126
325S:S:K653 9.51333659
326S:S:R656 4.642508
327S:S:W697 7.03333667
328S:S:R724 5.622568
329S:S:L741 4.0754124
330S:S:C742 7.81754129
331S:S:I762 5.84559
332S:S:M766 5.502509
333S:S:W773 4.634509
334S:S:I779 4.15754287
335S:S:Y787 6.354505
336S:S:K813 4.158559
337W:W:?902 10.6551040
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?901 R:R:Y144 39.21014.11YesYes103
2R:R:V147 R:R:Y144 20.79573.79YesYes143
3R:R:D95 R:R:V147 20.69232.92YesYes144
4R:R:D95 S:S:R177 16.71174.76YesNo045
5S:S:R177 S:S:Y178 16.63814.4NoYes056
6S:S:K171 S:S:Y178 10.07633.58NoYes036
7S:S:K171 S:S:T219 10.02374.5NoNo034
8R:R:S145 R:R:S169 30.86196.52NoYes087
9R:R:K171 R:R:S169 43.3896.12YesYes037
10R:R:K171 R:R:Y178 41.08314.78YesYes136
11R:R:R177 R:R:Y178 32.686218.52YesYes056
12R:R:R177 S:S:D95 29.37067.15YesNo054
13S:S:D146 S:S:D95 18.9016.65YesNo054
14S:S:D146 S:S:R271 14.00523.57YesYes155
15S:S:R271 S:S:Y144 14.101119.55YesYes153
16L:L:?901 R:R:D295 18.9992.86YesYes108
17R:R:R271 R:R:Y144 10.432122.64YesYes153
18L:L:?901 R:R:R57 11.396917.9YesYes104
19R:R:H56 R:R:Q60 12.47994.95YesYes037
20R:R:N153 R:R:Y178 12.05699.3YesYes156
21R:R:N153 R:R:R156 11.04024.82YesYes155
22R:R:R156 S:S:T96 11.41459.06YesYes152
23S:S:D95 S:S:T96 10.89215.78NoYes042
24L:L:?901 R:R:Y216 34.772424.68YesYes107
25R:R:S169 R:R:T219 13.98653.2YesNo074
26R:R:D188 R:R:T219 13.99834.34YesNo084
27R:R:Q191 R:R:Y216 31.49243.38YesYes187
28R:R:D295 R:R:Q191 20.048213.05YesYes188
29R:R:M195 R:R:Q191 67.36854.08YesYes078
30R:R:F269 R:R:Y216 31.51463.09YesYes177
31R:R:F269 R:R:M195 31.23849.95YesYes077
32R:R:M195 R:R:V292 1004.56YesNo077
33R:R:L199 R:R:V292 99.79564.47YesNo167
34R:R:I233 R:R:L199 99.61952.85YesYes166
35R:R:I233 R:R:R200 99.56842.51YesYes064
36R:R:R200 R:R:T205 99.39023.88YesNo047
37R:R:E239 R:R:V210 10.14098.56NoNo055
38R:R:E239 R:R:L257 13.27177.95NoNo057
39R:R:L257 R:R:S208 12.98376.01NoNo078
40R:R:S208 R:R:T237 12.40753.2NoNo086
41R:R:K260 R:R:T237 12.11934.5YesNo046
42R:R:D274 R:R:R271 12.53124.76YesYes145
43R:R:K260 R:R:Y206 10.96628.36YesYes1449
44R:R:C500 R:R:Y206 10.10195.38NoYes099
45R:R:R499 R:R:T205 99.33072.59NoNo057
46R:R:P503 R:R:R499 99.21185.76NoNo055
47R:R:E502 R:R:P503 99.15221.57NoNo045
48R:R:C504 R:R:E502 99.09271.52YesNo094
49R:R:C504 R:R:V509 98.73515.12YesNo096
50R:R:P524 R:R:V509 98.67548.84NoNo036
51R:R:I523 R:R:P524 98.61581.69YesNo043
52R:R:I523 R:R:K510 98.423211.63YesYes247
53R:R:C525 R:R:K510 49.195111.32NoYes297
54R:R:C525 R:R:E529 49.12863.04NoYes298
55R:R:E529 R:R:Y528 97.24036.73YesYes288
56R:R:W545 R:R:Y528 96.56131.93YesYes068
57R:R:C537 R:R:K510 49.19513.23NoYes297
58R:R:C537 R:R:E529 49.12869.12NoYes298
59R:R:E555 R:R:W545 94.16952.18NoYes036
60R:R:E555 R:R:V717 94.02947.13NoYes038
61R:R:K707 R:R:V717 93.48147.59YesYes028
62R:R:K707 R:R:L719 92.92044.23YesNo027
63R:R:L719 R:R:P627 89.55558.21NoYes979
64R:R:P627 R:R:R635 88.86594.32YesYes098
65R:R:M619 R:R:R635 87.88073.72YesYes078
66R:R:L639 R:R:M619 63.24632.83NoYes087
67R:R:F643 R:R:L639 62.97374.87YesNo088
68R:R:F643 R:R:Y647 19.08017.22YesYes486
69R:R:L738 R:R:Y647 19.65672.34NoYes096
70R:R:L738 R:R:Y734 19.5027.03NoYes098
71R:R:L686 R:R:Y734 18.72784.69NoYes058
72R:R:L686 R:R:S648 18.57294.5NoNo059
73R:R:I687 R:R:S648 18.4183.1NoNo079
74R:R:I687 R:R:V645 16.86794.61NoNo077
75R:R:G612 R:R:V645 16.71273.68NoNo087
76R:R:C646 R:R:G612 16.40241.96NoNo068
77R:R:C646 R:R:L609 16.24723.17NoYes068
78R:R:F623 R:R:M619 24.36149.95NoYes087
79R:R:F623 R:R:M794 24.21654.98NoNo089
80R:R:F780 R:R:M794 24.07587.46NoNo089
81R:R:F780 R:R:Q790 24.214314.05NoYes087
82R:R:Q790 R:R:T793 24.04642.83YesNo078
83R:R:T793 R:R:V789 23.89261.59NoNo085
84R:R:F643 R:R:W773 42.57457.02YesYes489
85R:R:T769 R:R:W773 43.18714.85NoYes089
86R:R:T769 R:R:V804 40.89484.76NoNo087
87R:R:I772 R:R:V804 40.60829.22NoNo087
88R:R:I772 S:S:I771 40.17834.42NoNo088
89S:S:C770 S:S:I771 35.32871.64NoNo078
90S:S:C770 S:S:I739 35.1791.64NoNo078
91S:S:I739 S:S:Y647 16.560910.88NoYes086
92S:S:C742 S:S:Y647 15.351113.44YesYes1296
93S:S:C742 S:S:T654 30.7533.38YesNo099
94S:S:I762 S:S:T654 30.1524.56YesNo099
95S:S:I762 S:S:K653 27.44017.27YesYes599
96S:S:K653 S:S:K813 21.12374.31YesYes599
97S:S:K813 S:S:P812 10.87643.35YesNo099
98S:S:F761 S:S:P812 10.272911.56NoNo059
99S:S:I739 S:S:M766 18.47145.83NoYes089
100S:S:C742 S:S:M766 15.7048.1YesYes099
101R:R:T783 R:R:V789 23.43231.59NoNo075
102R:R:T783 R:R:V782 23.2791.59NoNo078
103R:R:V782 S:S:I779 22.97094.61NoYes2887
104S:S:D49 S:S:T96 21.06664.34NoYes112
105S:S:D49 S:S:H97 21.026312.61NoYes113
106S:S:C92 S:S:H97 12.08977.37YesYes183
107S:S:L26 S:S:W344 10.82215.69YesYes154
108S:S:R156 S:S:Y180 14.55964.12YesYes356
109S:S:Y180 S:S:Y419 11.9517.94YesYes365
110S:S:E375 S:S:I378 14.85114.1YesYes157
111S:S:I779 S:S:T783 22.52113.04YesNo077
112S:S:Q790 S:S:T783 22.22952.83NoNo077
113S:S:F780 S:S:Q790 21.93814.05NoNo087
114S:S:F780 S:S:M794 21.50086.22NoNo089
115S:S:F623 S:S:M794 21.35578.71NoNo089
116S:S:F623 S:S:R635 22.056820.31NoYes088
117S:S:P627 S:S:R635 14.10582.88NoYes098
118R:R:S145 R:R:Y216 28.11695.09NoYes187
119R:R:D188 R:R:Q191 14.20313.92YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?901 S:S:R57 18.75 1 Yes Yes 0 4 0 1
M:M:?901 S:S:R61 7.67 1 Yes Yes 0 4 0 1
M:M:?901 S:S:S143 4.21 1 Yes Yes 0 4 0 1
M:M:?901 S:S:Y144 5.76 1 Yes Yes 0 3 0 1
M:M:?901 S:S:S145 4.21 1 Yes No 0 8 0 1
M:M:?901 S:S:A166 5.53 1 Yes Yes 0 5 0 1
M:M:?901 S:S:T168 5.17 1 Yes Yes 0 7 0 1
M:M:?901 S:S:Y216 26.32 1 Yes Yes 0 7 0 1
M:M:?901 S:S:K377 9.89 1 Yes Yes 0 3 0 1
S:S:P39 S:S:R61 2.88 1 Yes Yes 5 4 2 1
S:S:P39 S:S:S143 7.13 1 Yes Yes 5 4 2 1
S:S:P39 S:S:Y144 5.56 1 Yes Yes 5 3 2 1
S:S:R57 S:S:R61 8.53 1 Yes Yes 4 4 1 1
S:S:R57 S:S:S272 3.95 1 Yes No 4 2 1 2
S:S:G296 S:S:R57 3 0 No Yes 5 4 2 1
S:S:L300 S:S:R57 12.15 1 Yes Yes 5 4 2 1
S:S:E375 S:S:R57 6.98 1 Yes Yes 5 4 2 1
S:S:R61 S:S:S143 10.54 1 Yes Yes 4 4 1 1
S:S:R61 S:S:Y165 7.2 1 Yes Yes 4 8 1 2
S:S:A166 S:S:R61 2.77 1 Yes Yes 5 4 1 1
S:S:E375 S:S:R61 17.45 1 Yes Yes 5 4 2 1
S:S:K377 S:S:R61 4.95 1 Yes Yes 3 4 1 1
S:S:R61 S:S:V381 3.92 1 Yes Yes 4 7 1 2
S:S:S93 S:S:Y144 11.45 0 No Yes 1 3 2 1
S:S:S143 S:S:Y165 7.63 1 Yes Yes 4 8 1 2
S:S:A166 S:S:S143 3.42 1 Yes Yes 5 4 1 1
S:S:R271 S:S:Y144 19.55 1 Yes Yes 5 3 2 1
S:S:E273 S:S:Y144 8.98 1 No Yes 1 3 2 1
S:S:S145 S:S:S169 4.89 1 No No 8 7 1 2
S:S:S145 S:S:Y216 5.09 1 No Yes 8 7 1 1
S:S:V381 S:S:Y165 10.09 1 Yes Yes 7 8 2 2
S:S:A166 S:S:K377 4.82 1 Yes Yes 5 3 1 1
S:S:T168 S:S:V185 4.76 1 Yes Yes 7 7 1 2
S:S:D188 S:S:T168 4.34 1 Yes Yes 8 7 2 1
S:S:T168 S:S:Y216 4.99 1 Yes Yes 7 7 1 1
S:S:D295 S:S:T168 4.34 1 Yes Yes 8 7 2 1
S:S:D188 S:S:S169 2.94 1 Yes No 8 7 2 2
S:S:D188 S:S:Y216 9.2 1 Yes Yes 8 7 2 1
S:S:G217 S:S:Y216 4.35 0 No Yes 8 7 2 1
S:S:S294 S:S:Y216 6.36 0 No Yes 8 7 2 1
S:S:E273 S:S:R271 11.63 1 No Yes 1 5 2 2
S:S:L300 S:S:S272 3 1 Yes No 5 2 2 2
S:S:D295 S:S:K377 2.77 1 Yes Yes 8 3 2 1
S:S:E375 S:S:K377 4.05 1 Yes Yes 5 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?901 R:R:R57 17.9 1 Yes Yes 0 4 0 1
L:L:?901 R:R:R61 8.52 1 Yes Yes 0 4 0 1
L:L:?901 R:R:Y144 4.11 1 Yes Yes 0 3 0 1
L:L:?901 R:R:S145 4.21 1 Yes No 0 8 0 1
L:L:?901 R:R:A166 5.53 1 Yes Yes 0 5 0 1
L:L:?901 R:R:T168 5.17 1 Yes Yes 0 7 0 1
L:L:?901 R:R:Y216 24.68 1 Yes Yes 0 7 0 1
L:L:?901 R:R:D295 2.86 1 Yes Yes 0 8 0 1
L:L:?901 R:R:G296 3.6 1 Yes No 0 5 0 1
L:L:?901 R:R:K377 6.93 1 Yes Yes 0 3 0 1
R:R:P39 R:R:S143 7.13 0 Yes Yes 5 4 2 2
R:R:P39 R:R:Y144 6.95 0 Yes Yes 5 3 2 1
R:R:R57 R:R:R61 13.86 1 Yes Yes 4 4 1 1
R:R:R57 R:R:S272 9.22 1 Yes No 4 2 1 2
R:R:G296 R:R:R57 3 1 No Yes 5 4 1 1
R:R:L300 R:R:R57 4.86 1 Yes Yes 5 4 2 1
R:R:E375 R:R:R57 11.63 1 No Yes 5 4 2 1
R:R:R61 R:R:S143 5.27 1 Yes Yes 4 4 1 2
R:R:R61 R:R:Y165 3.09 1 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 1 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 1 No Yes 5 4 2 1
R:R:K377 R:R:R61 11.14 1 Yes Yes 3 4 1 1
R:R:R61 R:R:V381 3.92 1 Yes No 4 7 1 2
R:R:S93 R:R:Y144 8.9 0 No Yes 1 3 2 1
R:R:S143 R:R:Y165 6.36 1 Yes Yes 4 8 2 2
R:R:A166 R:R:S143 3.42 1 Yes Yes 5 4 1 2
R:R:V147 R:R:Y144 3.79 1 Yes Yes 4 3 2 1
R:R:R271 R:R:Y144 22.64 1 Yes Yes 5 3 2 1
R:R:E273 R:R:Y144 3.37 1 Yes Yes 1 3 2 1
R:R:S145 R:R:S169 6.52 1 No Yes 8 7 1 2
R:R:S145 R:R:Y216 5.09 1 No Yes 8 7 1 1
R:R:V381 R:R:Y165 8.83 1 No Yes 7 8 2 2
R:R:A166 R:R:K377 3.21 1 Yes Yes 5 3 1 1
R:R:T168 R:R:V185 4.76 1 Yes Yes 7 7 1 2
R:R:D188 R:R:T168 5.78 1 Yes Yes 8 7 2 1
R:R:T168 R:R:Y216 4.99 1 Yes Yes 7 7 1 1
R:R:D295 R:R:T168 4.34 1 Yes Yes 8 7 1 1
R:R:K377 R:R:V185 3.04 1 Yes Yes 3 7 1 2
R:R:D188 R:R:Q191 3.92 1 Yes Yes 8 8 2 2
R:R:D188 R:R:Y216 8.05 1 Yes Yes 8 7 2 1
R:R:Q191 R:R:Y216 3.38 1 Yes Yes 8 7 2 1
R:R:D295 R:R:Q191 13.05 1 Yes Yes 8 8 1 2
R:R:Q191 R:R:Y453 18.04 1 Yes Yes 8 8 2 2
R:R:F269 R:R:Y216 3.09 1 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 8.9 1 No Yes 8 7 2 1
R:R:D295 R:R:Y216 3.45 1 Yes Yes 8 7 1 1
R:R:F269 R:R:S294 5.28 1 Yes No 7 8 2 2
R:R:E273 R:R:R271 13.96 1 Yes Yes 1 5 2 2
R:R:L300 R:R:S272 3 1 Yes No 5 2 2 2
R:R:D295 R:R:E318 6.5 1 Yes No 8 6 1 2
R:R:D295 R:R:L319 5.43 1 Yes Yes 8 4 1 2
R:R:D295 R:R:Y453 4.6 1 Yes Yes 8 8 1 2
R:R:K377 R:R:L319 4.23 1 Yes Yes 3 4 1 2
R:R:L319 R:R:Y453 10.55 1 Yes Yes 4 8 2 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F643 R:R:L639 4.87 4 Yes No 8 8 1 2
R:R:F643 R:R:Y647 7.22 4 Yes Yes 8 6 1 1
R:R:F643 R:R:N735 4.83 4 Yes No 8 7 1 1
R:R:F643 R:R:W773 7.02 4 Yes Yes 8 9 1 1
R:R:F643 W:W:?902 15.83 4 Yes Yes 8 0 1 0
R:R:N735 R:R:Y647 9.3 4 No Yes 7 6 1 1
R:R:I739 R:R:Y647 7.25 0 No Yes 8 6 2 1
R:R:W773 R:R:Y647 20.26 4 Yes Yes 9 6 1 1
R:R:Y647 W:W:?902 8.96 4 Yes Yes 6 0 1 0
R:R:M728 R:R:N722 4.21 4 No No 7 6 1 2
R:R:D725 R:R:M728 4.16 4 No No 4 7 1 1
R:R:D725 R:R:L729 19 4 No No 4 5 1 2
R:R:D725 W:W:?902 12.45 4 No Yes 4 0 1 0
R:R:M728 W:W:?902 11.89 4 No Yes 7 0 1 0
R:R:L732 R:R:L777 4.15 4 No No 8 7 1 1
R:R:L732 W:W:?902 13.75 4 No Yes 8 0 1 0
R:R:N735 W:W:?902 12.59 4 No Yes 7 0 1 0
R:R:T769 R:R:W773 4.85 0 No Yes 8 9 2 1
R:R:S801 R:R:W773 8.65 0 No Yes 9 9 2 1
R:R:W773 W:W:?902 9.58 4 Yes Yes 9 0 1 0
R:R:L777 R:R:P778 3.28 4 No No 7 8 1 2
R:R:L777 W:W:?902 3.17 4 No Yes 7 0 1 0
R:R:F780 R:R:Q790 14.05 0 No Yes 8 7 1 2
R:R:F780 R:R:M794 7.46 0 No No 8 9 1 2
R:R:F780 W:W:?902 14.89 0 No Yes 8 0 1 0
R:R:Q790 R:R:S784 8.66 0 Yes No 7 6 2 1
R:R:S784 W:W:?902 3.44 0 No Yes 6 0 1 0
R:R:L738 R:R:Y647 2.34 0 No Yes 9 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7E9G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.77
Number of Linked Nodes 1437
Number of Links 1865
Number of Hubs 337
Number of Links mediated by Hubs 1185
Number of Communities 36
Number of Nodes involved in Communities 461
Number of Links involved in Communities 726
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 13487938
Length Of Smallest Path 3
Average Path Length 47.0497
Length of Longest Path 83
Minimum Path Strength 1.315
Average Path Strength 5.59299
Maximum Path Strength 25.2
Minimum Path Correlation 0.71
Average Path Correlation 0.999366
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 58.8125
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.6897
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code40F
PDB ResiduesL:L:?901 M:M:?901
Environment DetailsOpen EMBL-EBI Page
Code40F
Name(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Synonyms
Identifier
FormulaC8 H11 N O4
Molecular Weight185.177
SMILES
PubChem213056
Formal Charge0
Total Atoms24
Total Chiral Atoms4
Total Bonds25
Total Aromatic Bonds0

CodeHZR
PDB ResiduesW:W:?902
Environment DetailsOpen EMBL-EBI Page
CodeHZR
NameJNJ-40411813
SynonymsJNJ-40411813
Identifier
FormulaC20 H25 Cl N2 O
Molecular Weight344.878
SMILES
PubChem25195461
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_nogp_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLIT 
GVIGGSYSD VSIQVANLL RLFQIPQIS YASTSAKLS DKSRYDYFA 
RTVPPDFFQ AKAMAEILR FFNWTYVST VASEGDYGE TGIEAFELE 
ARARNICVA TSEKVGRAM SRAAFEGVV RALLQKPSA RVAVLFTRS 
EDARELLAA SQRLNASFT WVASDGWGA LESVVAGSE GAAEGAITI 
ELASYPISD FASYFQSLD PWNNSRNPW FREFWEQRF RCSFRQRDC 
AAHSLRAVP FEQESKIMF VVNAVYAMA HALHNMHRA LCPNTTRLC 
DAMRPVNGR RLYKDFVLN VKFDAPFRP ADTHNEVRF DRFGDGIGR 
YNIFTYLRA GSGRYRYQK VGYWAEGLT LDTSLIPWA SPSAGPLPA 
SRCSEPCLQ NEVKSVQPG EVCCWLCIP CQPYEYRLD EFTCADCGL 
GYWPNASLT GCFELPQEY IRWGDAWAV GPVTIACLG ALATLFVLG 
VFVRHNATP VVKAAGREL CYILLGGVF LCYCMTFIF IAKPSTAVC 
TLRRLGLGT AFSVCYSAL LTKTNRIAR IFGGAREGA QRPRFISPA 
SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER REVVTLRCN 
HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE AKFIGFTMY 
TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS VVLGCLFAP 
KLHI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_nogp_Chain_S
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLTA 
ITGVIGGSY SDVSIQVAN LLRLFQIPQ ISYASTSAK LSDKSRYDY 
FARTVPPDF FQAKAMAEI LRFFNWTYV STVASEGDY GETGIEAFE 
LEARARNIC VATSEKVGR AMSRAAFEG VVRALLQKP SARVAVLFT 
RSEDARELL AASQRLNAS FTWVASDGW GALESVVAG SEGAAEGAI 
TIELASYPI SDFASYFQS LDPWNNSRN PWFREFWEQ RFRCSFRQR 
DCAAHSLRA VPFEQESKI MFVVNAVYA MAHALHNMH RALCPNTTR 
LCDAMRPVN GRRLYKDFV LNVKFDAPF RPADTHNEV RFDRFGDGI 
GRYNIFTYL RAGSGRYRY QKVGYWAEG LTLDTSLIP WASPSAGPL 
PASRCSEPC LQNEVKSVQ PGEVCCWLC IPCQPYEYR LDEFTCADC 
GLGYWPNAS LTGCFELPQ EYIRWGDAW AVGPVTIAC LGALATLFV 
LGVFVRHNA TPVVKAAGR ELCYILLGG VFLCYCMTF IFIAKPSTA 
VCTLRRLGL GTAFSVCYS ALLTKTNRI SPASQVAIC LALISGQLL 
IVVAWLVVE APGTGKETA PERREVVTL RCNHRDASM LGSLAYNVL 
LIALCTLYA FKTRKCPEN FNEAKFIGF TMYTTCIIW LAFLPIFYV 
TSSDYRVQT TTMCVSVSL SGSVVLGCL FAPKLHII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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