| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E9G | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu2 | Homo Sapiens | Eglumetad | JNJ-40411813 | Gi1/Beta1/Gamma2 | 3.5 | 2021-06-23 | 10.1038/s41586-021-03495-2 |
|
A 2D representation of the interactions of HZR in 7E9G
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F623 | R:R:M619 | 9.95 | 6 | No | Yes | 8 | 7 | 2 | 2 | | R:R:L639 | R:R:M619 | 2.83 | 6 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:F623 | R:R:L639 | 2.44 | 6 | No | Yes | 8 | 8 | 2 | 1 | | R:R:F623 | R:R:M794 | 4.98 | 6 | No | No | 8 | 9 | 2 | 2 | | R:R:G640 | R:R:L639 | 3.42 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:F643 | R:R:L639 | 4.87 | 6 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:L639 | W:W:?902 | 2.12 | 6 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:F643 | R:R:Y647 | 7.22 | 6 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:F643 | R:R:N735 | 4.83 | 6 | Yes | No | 8 | 7 | 1 | 1 | | R:R:F643 | R:R:W773 | 7.02 | 6 | Yes | Yes | 8 | 9 | 1 | 1 | | R:R:F643 | W:W:?902 | 15.83 | 6 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:N735 | R:R:Y647 | 9.3 | 6 | No | Yes | 7 | 6 | 1 | 1 | | R:R:L738 | R:R:Y647 | 2.34 | 0 | No | Yes | 9 | 6 | 2 | 1 | | R:R:I739 | R:R:Y647 | 7.25 | 6 | No | Yes | 8 | 6 | 2 | 1 | | R:R:W773 | R:R:Y647 | 20.26 | 6 | Yes | Yes | 9 | 6 | 1 | 1 | | R:R:Y647 | W:W:?902 | 8.96 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | | R:R:M728 | R:R:N722 | 4.21 | 6 | No | No | 7 | 6 | 1 | 2 | | R:R:D725 | R:R:M728 | 4.16 | 6 | No | No | 4 | 7 | 1 | 1 | | R:R:D725 | R:R:L729 | 19 | 6 | No | No | 4 | 5 | 1 | 2 | | R:R:D725 | W:W:?902 | 12.45 | 6 | No | Yes | 4 | 0 | 1 | 0 | | R:R:M728 | W:W:?902 | 11.89 | 6 | No | Yes | 7 | 0 | 1 | 0 | | R:R:L732 | R:R:L777 | 4.15 | 6 | No | No | 8 | 7 | 1 | 1 | | R:R:L732 | W:W:?902 | 13.75 | 6 | No | Yes | 8 | 0 | 1 | 0 | | R:R:N735 | W:W:?902 | 12.59 | 6 | No | Yes | 7 | 0 | 1 | 0 | | R:R:I739 | R:R:W773 | 2.35 | 6 | No | Yes | 8 | 9 | 2 | 1 | | R:R:T769 | R:R:W773 | 4.85 | 0 | No | Yes | 8 | 9 | 2 | 1 | | R:R:S801 | R:R:W773 | 8.65 | 0 | No | Yes | 9 | 9 | 2 | 1 | | R:R:W773 | W:W:?902 | 9.58 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:L777 | R:R:P778 | 3.28 | 6 | No | No | 7 | 8 | 1 | 2 | | R:R:L777 | W:W:?902 | 3.17 | 6 | No | Yes | 7 | 0 | 1 | 0 | | R:R:F780 | R:R:Q790 | 14.05 | 6 | No | Yes | 8 | 7 | 1 | 1 | | R:R:F780 | R:R:M794 | 7.46 | 6 | No | No | 8 | 9 | 1 | 2 | | R:R:F780 | W:W:?902 | 14.89 | 6 | No | Yes | 8 | 0 | 1 | 0 | | R:R:Q790 | R:R:S784 | 8.66 | 6 | Yes | No | 7 | 6 | 1 | 1 | | R:R:S784 | W:W:?902 | 3.44 | 6 | No | Yes | 6 | 0 | 1 | 0 | | R:R:Q790 | R:R:Y787 | 34.95 | 6 | Yes | No | 7 | 5 | 1 | 2 | | R:R:Q790 | R:R:T793 | 2.83 | 6 | Yes | No | 7 | 8 | 1 | 2 | | R:R:Q790 | W:W:?902 | 2.03 | 6 | Yes | Yes | 7 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 12.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 9.22 | | Average Nodes In Shell | 26.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 38.00 | | Average Links Mediated by Hubs In Shell | 31.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JD3 | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu3 | Homo Sapiens | Glutamate | HZR; PEF | Gi1/Beta1/Gamma2 | 3.3 | 2023-06-21 | 10.1038/s41422-023-00830-2 |
|
A 2D representation of the interactions of HZR in 8JD3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:F623 | R:R:M619 | 4.98 | 6 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:L639 | R:R:M619 | 2.83 | 6 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:F623 | R:R:L639 | 4.87 | 6 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:F623 | R:R:M794 | 4.98 | 6 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:L639 | R:R:M728 | 5.65 | 6 | Yes | No | 8 | 7 | 1 | 1 | | R:R:L639 | W:W:?1 | 6.35 | 6 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:G640 | R:R:Q690 | 3.29 | 6 | No | Yes | 6 | 9 | 1 | 2 | | R:R:G640 | R:R:S731 | 1.86 | 6 | No | No | 6 | 7 | 1 | 1 | | R:R:G640 | W:W:?1 | 2.61 | 6 | No | Yes | 6 | 0 | 1 | 0 | | R:R:F643 | R:R:Y647 | 7.22 | 6 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:F643 | R:R:N735 | 2.42 | 6 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F643 | R:R:W773 | 7.02 | 6 | Yes | Yes | 8 | 9 | 1 | 1 | | R:R:F643 | R:R:V798 | 3.93 | 6 | Yes | No | 8 | 8 | 1 | 2 | | R:R:F643 | W:W:?1 | 12.1 | 6 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:Q690 | R:R:S644 | 5.78 | 6 | Yes | No | 9 | 8 | 2 | 2 | | R:R:S644 | R:R:Y734 | 2.54 | 6 | No | Yes | 8 | 8 | 2 | 2 | | R:R:N735 | R:R:S644 | 2.98 | 6 | Yes | No | 7 | 8 | 1 | 2 | | R:R:N735 | R:R:Y647 | 6.98 | 6 | Yes | Yes | 7 | 6 | 1 | 1 | | R:R:L738 | R:R:Y647 | 2.34 | 0 | No | Yes | 9 | 6 | 2 | 1 | | R:R:I739 | R:R:Y647 | 13.3 | 6 | No | Yes | 8 | 6 | 1 | 1 | | R:R:T769 | R:R:Y647 | 3.75 | 0 | No | Yes | 8 | 6 | 2 | 1 | | R:R:Y647 | W:W:?1 | 8.96 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | | R:R:Q690 | R:R:S731 | 8.66 | 6 | Yes | No | 9 | 7 | 2 | 1 | | R:R:Q690 | R:R:Y734 | 5.64 | 6 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:R720 | R:R:R724 | 5.33 | 6 | No | Yes | 6 | 8 | 2 | 2 | | R:R:D725 | R:R:R720 | 3.57 | 6 | Yes | No | 4 | 6 | 1 | 2 | | R:R:D725 | R:R:R724 | 5.96 | 6 | Yes | Yes | 4 | 8 | 1 | 2 | | R:R:F780 | R:R:R724 | 7.48 | 6 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:D725 | R:R:M728 | 2.77 | 6 | Yes | No | 4 | 7 | 1 | 1 | | R:R:D725 | R:R:F780 | 14.33 | 6 | Yes | Yes | 4 | 8 | 1 | 1 | | R:R:D725 | R:R:M794 | 4.16 | 6 | Yes | Yes | 4 | 9 | 1 | 2 | | R:R:D725 | W:W:?1 | 16.6 | 6 | Yes | Yes | 4 | 0 | 1 | 0 | | R:R:M728 | W:W:?1 | 4.32 | 6 | No | Yes | 7 | 0 | 1 | 0 | | R:R:S731 | W:W:?1 | 3.44 | 6 | No | Yes | 7 | 0 | 1 | 0 | | R:R:L732 | W:W:?1 | 12.69 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:N735 | R:R:Y734 | 2.33 | 6 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:L738 | R:R:Y734 | 9.38 | 0 | No | Yes | 9 | 8 | 2 | 2 | | R:R:N735 | W:W:?1 | 11.54 | 6 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:I739 | R:R:M766 | 8.75 | 6 | No | No | 8 | 9 | 1 | 2 | | R:R:I739 | W:W:?1 | 2.18 | 6 | No | Yes | 8 | 0 | 1 | 0 | | R:R:F776 | R:R:W773 | 7.02 | 6 | Yes | Yes | 9 | 9 | 1 | 1 | | R:R:S797 | R:R:W773 | 3.71 | 6 | No | Yes | 9 | 9 | 2 | 1 | | R:R:S801 | R:R:W773 | 3.71 | 0 | No | Yes | 9 | 9 | 2 | 1 | | R:R:W773 | W:W:?1 | 21.76 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:F776 | R:R:F780 | 4.29 | 6 | Yes | Yes | 9 | 8 | 1 | 1 | | R:R:F776 | R:R:T793 | 5.19 | 6 | Yes | No | 9 | 8 | 1 | 2 | | R:R:F776 | R:R:M794 | 3.73 | 6 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:F776 | R:R:S797 | 3.96 | 6 | Yes | No | 9 | 9 | 1 | 2 | | R:R:F776 | W:W:?1 | 3.72 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:F780 | R:R:Q790 | 4.68 | 6 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:F780 | R:R:M794 | 2.49 | 6 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:F780 | W:W:?1 | 4.65 | 6 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:V736 | W:W:?1 | 1.14 | 0 | No | Yes | 5 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 14.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 8.00 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 16.00 | | Average Links In Shell | 53.00 | | Average Links Mediated by Hubs In Shell | 51.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JD5 | C | Aminoacid | Metabotropic Glutamate | mGlu2; mGlu4 | Homo Sapiens | Glutamate | BQI; HZE; PEF | Gi1/Beta1/Gamma2 | 3.6 | 2023-06-21 | 10.1038/s41422-023-00830-2 |
|
A 2D representation of the interactions of HZR in 8JD5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L639 | R:R:M619 | 4.24 | 4 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:F643 | R:R:L639 | 2.44 | 4 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:L639 | R:R:M728 | 2.83 | 4 | Yes | No | 8 | 7 | 1 | 1 | | R:R:L639 | W:W:?1 | 3.17 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:F643 | R:R:Y647 | 3.09 | 4 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:F643 | R:R:N735 | 2.42 | 4 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:F643 | R:R:W773 | 2 | 4 | Yes | Yes | 8 | 9 | 1 | 1 | | R:R:F643 | R:R:V798 | 7.87 | 4 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:F643 | R:R:S801 | 3.96 | 4 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:F643 | W:W:?1 | 10.24 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:N735 | R:R:S644 | 2.98 | 4 | Yes | No | 7 | 8 | 1 | 2 | | R:R:C646 | R:R:Y647 | 2.69 | 0 | Yes | Yes | 6 | 6 | 2 | 1 | | R:R:I739 | R:R:Y647 | 7.25 | 4 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:M766 | R:R:Y647 | 2.39 | 4 | Yes | Yes | 9 | 6 | 2 | 1 | | R:R:T769 | R:R:Y647 | 6.24 | 4 | Yes | Yes | 8 | 6 | 1 | 1 | | R:R:V805 | R:R:Y647 | 3.79 | 0 | No | Yes | 7 | 6 | 2 | 1 | | R:R:Y647 | W:W:?1 | 2.69 | 4 | Yes | Yes | 6 | 0 | 1 | 0 | | R:R:D725 | R:R:H723 | 7.56 | 4 | No | Yes | 4 | 5 | 1 | 2 | | R:R:D725 | R:R:F780 | 2.39 | 4 | No | Yes | 4 | 8 | 1 | 1 | | R:R:D725 | W:W:?1 | 3.11 | 4 | No | Yes | 4 | 0 | 1 | 0 | | R:R:M728 | W:W:?1 | 6.48 | 4 | No | Yes | 7 | 0 | 1 | 0 | | R:R:L732 | W:W:?1 | 12.69 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L738 | R:R:N735 | 4.12 | 0 | No | Yes | 9 | 7 | 2 | 1 | | R:R:N735 | W:W:?1 | 7.35 | 4 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:I739 | R:R:L738 | 2.85 | 4 | Yes | No | 8 | 9 | 1 | 2 | | R:R:I739 | R:R:M766 | 4.37 | 4 | Yes | Yes | 8 | 9 | 1 | 2 | | R:R:I739 | W:W:?1 | 3.27 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:M766 | R:R:T765 | 3.01 | 4 | Yes | Yes | 9 | 9 | 2 | 2 | | R:R:T765 | R:R:T769 | 1.57 | 4 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:T765 | R:R:V804 | 1.59 | 4 | Yes | Yes | 9 | 7 | 2 | 2 | | R:R:T765 | R:R:V805 | 3.17 | 4 | Yes | No | 9 | 7 | 2 | 2 | | R:R:T769 | R:R:W773 | 2.43 | 4 | Yes | Yes | 8 | 9 | 1 | 1 | | R:R:S801 | R:R:T769 | 1.6 | 4 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:T769 | R:R:V804 | 1.59 | 4 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:T769 | W:W:?1 | 2.25 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:F776 | R:R:W773 | 6.01 | 4 | Yes | Yes | 9 | 9 | 2 | 1 | | R:R:S797 | R:R:W773 | 2.47 | 4 | No | Yes | 9 | 9 | 2 | 1 | | R:R:V798 | R:R:W773 | 2.45 | 4 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:S801 | R:R:W773 | 6.18 | 4 | Yes | Yes | 9 | 9 | 2 | 1 | | R:R:W773 | W:W:?1 | 20.02 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:F776 | R:R:F780 | 2.14 | 4 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F776 | R:R:M794 | 2.49 | 4 | Yes | No | 9 | 9 | 2 | 2 | | R:R:F776 | R:R:S797 | 7.93 | 4 | Yes | No | 9 | 9 | 2 | 2 | | R:R:L777 | R:R:P778 | 1.64 | 4 | No | Yes | 7 | 8 | 1 | 2 | | R:R:L777 | W:W:?1 | 3.17 | 4 | No | Yes | 7 | 0 | 1 | 0 | | R:R:L777 | X:X:?2 | 3.41 | 4 | No | Yes | 7 | 0 | 1 | 2 | | R:R:P778 | S:S:W587 | 4.05 | 4 | Yes | Yes | 8 | 5 | 2 | 2 | | R:R:P778 | X:X:?2 | 9.45 | 4 | Yes | Yes | 8 | 0 | 2 | 2 | | R:R:F780 | R:R:Y781 | 5.16 | 4 | Yes | No | 8 | 6 | 1 | 1 | | R:R:F780 | R:R:Q790 | 14.05 | 4 | Yes | No | 8 | 7 | 1 | 2 | | R:R:F780 | R:R:M794 | 2.49 | 4 | Yes | No | 8 | 9 | 1 | 2 | | R:R:F780 | W:W:?1 | 9.31 | 4 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:Y781 | S:S:W587 | 4.82 | 4 | No | Yes | 6 | 5 | 1 | 2 | | R:R:Y781 | W:W:?1 | 8.06 | 4 | No | Yes | 6 | 0 | 1 | 0 | | S:S:W587 | X:X:?2 | 8.42 | 4 | Yes | Yes | 5 | 0 | 2 | 2 | | R:R:L732 | R:R:V736 | 1.49 | 0 | No | No | 8 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 13.00 | | Average Number Of Links With An Hub | 8.00 | | Average Interaction Strength | 7.06 | | Average Nodes In Shell | 33.00 | | Average Hubs In Shell | 21.00 | | Average Links In Shell | 56.00 | | Average Links Mediated by Hubs In Shell | 55.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
