Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:G27 3.44754155
2A:A:V34 4.1375445
3A:A:L36 4.372547
4A:A:L38 4.5375448
5A:A:L39 2.686539
6A:A:M53 5.9285258
7A:A:I184 3.8075409
8A:A:H188 8.1075423
9A:A:F191 10.28545
10A:A:F196 6.86333647
11A:A:K197 8.03426
12A:A:M198 2.73447
13A:A:F199 6.665425
14A:A:D200 4.215449
15A:A:V201 5.01439
16A:A:Q204 5.274539
17A:A:S206 4.8375438
18A:A:E207 8.07439
19A:A:R208 6.28439
20A:A:K210 6.16333639
21A:A:W211 6.35143739
22A:A:H213 8.95428
23A:A:T219 2.822547
24A:A:A220 2.105448
25A:A:I222 5.08547
26A:A:F223 4.315639
27A:A:C224 3.412547
28A:A:L227 8.934167
29A:A:Y230 5.64714738
30A:A:L234 5.58408
31A:A:R242 5.4125409
32A:A:M247 4.5625436
33A:A:F250 4.74143739
34A:A:W258 11.148525
35A:A:I264 5.6225436
36A:A:I265 3.24333648
37A:A:L266 3.992539
38A:A:F267 4.154549
39A:A:L273 6.0675406
40A:A:F274 7.37409
41A:A:L283 5.1725437
42A:A:C286 5.075436
43A:A:Y287 3.48167637
44A:A:Y290 6.9925437
45A:A:Y296 5.9456164
46A:A:E298 4.375434
47A:A:F307 3.39667638
48A:A:E318 6.7575444
49A:A:Y320 5.27167647
50A:A:T321 8.255405
51A:A:F323 5.3756164
52A:A:F336 5.27548
53A:A:N347 4.3654108
54A:A:L348 4.445109
55A:A:C351 4.6054104
56B:B:L30 7.27254275
57B:B:T34 4.1475425
58B:B:I37 4.444522
59B:B:R48 18.692527
60B:B:R49 13.4425427
61B:B:L51 9.06429
62B:B:H54 8.48833629
63B:B:K57 11.1875429
64B:B:I58 5.4325429
65B:B:Y59 12.875428
66B:B:M61 4.795406
67B:B:W63 5.46875827
68B:B:S67 5.59425
69B:B:R68 11.865425
70B:B:L70 5.546525
71B:B:V71 4.65458
72B:B:D76 3.788577159
73B:B:K78 5.7025158
74B:B:I80 8.1875428
75B:B:I81 4.18557
76B:B:W82 9.13667629
77B:B:D83 9.0175428
78B:B:Y85 13.9525424
79B:B:T86 5.98426
80B:B:N88 5.01427
81B:B:K89 8.00833629
82B:B:H91 7.426555
83B:B:I93 3.88457
84B:B:L95 4.7125458
85B:B:W99 8.562529
86B:B:V100 2.7975459
87B:B:Y105 3.68714756
88B:B:Y111 7.015634
89B:B:A113 2.598539
90B:B:G115 2.3275439
91B:B:N119 3.3275439
92B:B:I120 4.982556
93B:B:C121 3.315638
94B:B:I123 3.22714736
95B:B:Y124 4.96756
96B:B:L126 4.865455
97B:B:V133 6.0475454
98B:B:H142 7.90429739
99B:B:G144 3.04408
100B:B:Y145 4.97625838
101B:B:L146 3.754537
102B:B:C148 3.3925436
103B:B:C149 2.75143738
104B:B:R150 6.1225436
105B:B:F151 6.25167639
106B:B:L152 4.8975433
107B:B:Q156 7435
108B:B:I157 7.19437
109B:B:T159 5.1025439
110B:B:S160 3.53536
111B:B:S161 5.844539
112B:B:G162 2.905439
113B:B:D163 7.125639
114B:B:C166 3.47538
115B:B:W169 11.294538
116B:B:T173 2.955405
117B:B:Q176 8.4925434
118B:B:F180 8.592537
119B:B:H183 7.575639
120B:B:D186 4.98539
121B:B:V187 3.144539
122B:B:M188 5.6325438
123B:B:L190 4.16714735
124B:B:L192 4.5535
125B:B:F199 5.96286739
126B:B:V200 4.476676126
127B:B:S201 2.664539
128B:B:G202 2.3406
129B:B:C204 5.5375437
130B:B:D205 6.146539
131B:B:A208 1.73754126
132B:B:K209 14.112536
133B:B:L210 4.73405
134B:B:W211 10.2314738
135B:B:E215 4.9625403
136B:B:H225 7.1675409
137B:B:S227 5.23436
138B:B:D228 3.7975439
139B:B:I232 4.438336128
140B:B:F234 3.883336125
141B:B:F235 7.2625826
142B:B:P236 4.002527
143B:B:N237 8.88525
144B:B:N239 5.716522
145B:B:F241 6.701676126
146B:B:T243 3.448336128
147B:B:D246 6.9425439
148B:B:L252 3.215427
149B:B:D254 5.722529
150B:B:Y264 5.43833625
151B:B:I269 5.71524
152B:B:I273 4.624526
153B:B:V276 4.445426
154B:B:F278 5.805627
155B:B:S279 5.33429
156B:B:S281 2.95529
157B:B:R283 6.08167629
158B:B:L285 4.965426
159B:B:L286 6.4725427
160B:B:A287 2.72526
161B:B:G288 2.7825427
162B:B:Y289 5.126527
163B:B:D291 5.2675428
164B:B:C294 4.27425
165B:B:W297 7.28628
166B:B:L300 4.795626
167B:B:R304 4.215625
168B:B:H311 8.854529
169B:B:R314 10.9586728
170B:B:V315 2.946527
171B:B:C317 2.59427
172B:B:L318 5.642526
173B:B:V320 3.836527
174B:B:T321 4.99667627
175B:B:D323 7.5375427
176B:B:G324 1.795829
177B:B:M325 4.66525
178B:B:A326 2.8375427
179B:B:V327 5.72426
180B:B:T329 6.075428
181B:B:G330 2.265425
182B:B:W332 11.1714729
183B:B:D333 7.71429
184B:B:L336 5.15527
185B:B:I338 3.02167625
186B:B:W339 10.18529
187G:G:L37 4.86427
188G:G:M38 5.695424
189G:G:Y40 8.39526
190G:G:C41 3.8025427
191G:G:D48 6.25333629
192G:G:L50 6.10143729
193G:G:F61 9.66429728
194L:L:?901 7.348331210
195M:M:?901 9.0071010
196R:R:V25 2.99414
197R:R:L26 4.0075415
198R:R:G35 3.0175419
199R:R:G36 2.166518
200R:R:F38 9.548518
201R:R:P39 3.94286715
202R:R:V40 6.835416
203R:R:H41 6.81718
204R:R:K43 3.714513
205R:R:G44 2.325414
206R:R:C50 5.27419
207R:R:V53 5.3675413
208R:R:E55 2.5525415
209R:R:H56 6.694503
210R:R:R57 10.0783614
211R:R:I59 4.9875416
212R:R:Q60 5.335417
213R:R:R61 6.2741014
214R:R:L62 5.44515
215R:R:E63 5.17125818
216R:R:A64 3.05417
217R:R:M65 5.17419
218R:R:F67 9.132517
219R:R:R71 8.722517
220R:R:I72 7.395419
221R:R:L78 5.86667617
222R:R:L79 4.25409
223R:R:V82 4.775415
224R:R:L84 3.886509
225R:R:H87 5.502514
226R:R:I88 6.884517
227R:R:L89 7.175415
228R:R:D90 8.71419
229R:R:S91 2.8475416
230R:R:C92 8.905418
231R:R:K94 4.475413
232R:R:D95 8.5225414
233R:R:H97 10.3325413
234R:R:L99 6.95515
235R:R:Q101 8.072515
236R:R:F105 5.87167616
237R:R:I136 3.648516
238R:R:G138 3.225417
239R:R:V139 3.152517
240R:R:I140 4.106517
241R:R:G141 2.712518
242R:R:G142 2.38415
243R:R:S143 4.858514
244R:R:Y144 8.29333613
245R:R:D146 7.644515
246R:R:V147 3.03614
247R:R:S148 3.94167617
248R:R:I149 7.7275415
249R:R:N153 8.5225415
250R:R:L155 5.04416
251R:R:R156 6.244515
252R:R:L157 4.3875415
253R:R:F158 6.354516
254R:R:P161 2.86167619
255R:R:Q162 6.1725418
256R:R:I163 4.18571717
257R:R:S164 3.9419
258R:R:Y165 7.40714718
259R:R:A166 3.796515
260R:R:T168 5.008517
261R:R:S169 5.4625407
262R:R:K171 6.08513
263R:R:L172 7.00833617
264R:R:S173 4.34418
265R:R:R177 7.61333615
266R:R:Y178 9.496516
267R:R:Y180 9.92416
268R:R:F181 6.57429719
269R:R:A182 2.356516
270R:R:R183 7.75667619
271R:R:T184 5.1375409
272R:R:V185 5.058517
273R:R:P186 3.49714718
274R:R:P187 6.37667617
275R:R:D188 4.754518
276R:R:F190 7.12833615
277R:R:Q191 7.535618
278R:R:K193 7.385413
279R:R:M195 5.74417
280R:R:E197 8.442516
281R:R:I198 4.3075418
282R:R:L199 4.255616
283R:R:R200 3.4075404
284R:R:F201 4.995415
285R:R:F202 5.57818
286R:R:W204 7.696519
287R:R:Y206 6.1425179
288R:R:V207 3.715418
289R:R:S208 3.215178
290R:R:T209 3.352516
291R:R:S212 4.4675416
292R:R:D215 4.9775415
293R:R:Y216 7.70375817
294R:R:I221 4.4825405
295R:R:F224 4.58517
296R:R:E227 4.7075415
297R:R:R231 4.896514
298R:R:I233 2.838516
299R:R:A236 3.0125178
300R:R:V241 4.01416
301R:R:R243 11.0925412
302R:R:M245 4.925413
303R:R:F250 7.042513
304R:R:E251 5.3575412
305R:R:V254 2.816515
306R:R:K260 5.4465174
307R:R:A263 1.974177
308R:R:V265 5.0375418
309R:R:V267 6.82416
310R:R:L268 4.3375415
311R:R:F269 6.17167617
312R:R:T270 3.81414
313R:R:R271 8.41667915
314R:R:E273 5.494511
315R:R:D274 4.9614
316R:R:L278 4.156515
317R:R:L279 5.9925415
318R:R:S282 3.2075414
319R:R:R284 9.115413
320R:R:A287 2.7275414
321R:R:W291 6.11286717
322R:R:D295 5.74714718
323R:R:W297 6.98625816
324R:R:L300 4.696515
325R:R:V303 5.9325414
326R:R:V304 6.068514
327R:R:E308 7.4414
328R:R:I317 3.302516
329R:R:E318 5.916506
330R:R:L319 6.404514
331R:R:Y322 6.278513
332R:R:I324 4.366516
333R:R:D326 5.14414
334R:R:F327 6.29778918
335R:R:Y330 6.624518
336R:R:F331 4.81125816
337R:R:L334 6.804515
338R:R:P336 13.315416
339R:R:N339 5.6775414
340R:R:R341 5.446504
341R:R:N342 6.29167617
342R:R:W344 6.24571714
343R:R:F345 5.26714714
344R:R:F348 5.54833616
345R:R:W349 7.73625818
346R:R:F353 10.696517
347R:R:F357 9.0725413
348R:R:C362 4.745419
349R:R:L367 4.0125416
350R:R:F372 7.63167615
351R:R:Q374 5.792515
352R:R:K377 4.81857713
353R:R:I378 5.302517
354R:R:M379 7.495408
355R:R:F380 8.13516
356R:R:V382 2.8675408
357R:R:N383 5.2025408
358R:R:Y386 8.05571716
359R:R:A387 2.22167618
360R:R:M388 4.2075416
361R:R:M395 3.8225415
362R:R:C400 3.604513
363R:R:L406 5.1675412
364R:R:M410 3.96412
365R:R:L418 3.602517
366R:R:Y419 3.69615
367R:R:F422 5.68375814
368R:R:V426 2.4875417
369R:R:F428 8.77833618
370R:R:A430 2.3425414
371R:R:P431 7.28833617
372R:R:F432 8.42667614
373R:R:R433 4.558513
374R:R:V441 5.566516
375R:R:F443 4.99429718
376R:R:F446 4.5575417
377R:R:D448 6.18571717
378R:R:Y453 7.33571718
379R:R:I455 4.56418
380R:R:F456 4.288515
381R:R:Y458 8.148515
382R:R:L459 4.56754326
383R:R:Y468 5.4614
384R:R:W474 6.85286716
385R:R:L478 6.0225416
386R:R:I485 6.8325417
387R:R:W487 5.2425817
388R:R:A488 4.13411
389R:R:C504 4.13254209
390R:R:K510 7.305497
391R:R:I523 5.5775494
392R:R:Y528 7.26333698
393R:R:E529 7.136598
394R:R:D539 6.3775493
395R:R:L542 4.45494
396R:R:W545 3.3375406
397R:R:E559 6.0575466
398R:R:Y560 4.02754216
399R:R:T582 4.365477
400R:R:L586 3.174575
401R:R:F589 4.7625479
402R:R:H592 3.8825474
403R:R:N593 4.5375475
404R:R:T595 4.2275479
405R:R:V598 3.9725479
406R:R:L605 5.75408
407R:R:Y607 5.246578
408R:R:L609 4.648508
409R:R:L610 2.782579
410R:R:G612 2.365408
411R:R:V613 3.03167678
412R:R:Y617 4.15143778
413R:R:M619 4.234567
414R:R:T620 5.32477
415R:R:P627 4.16569
416R:R:R635 3.694568
417R:R:R636 4.9625408
418R:R:L639 3.136568
419R:R:T641 3.54254366
420R:R:F643 7.954568
421R:R:C646 2.165406
422R:R:Y647 9.22167666
423R:R:T654 4.5254239
424R:R:R656 7.8925108
425R:R:R659 5.6445107
426R:R:I660 4.6645109
427R:R:E666 3.6775447
428R:R:G667 3.195445
429R:R:C683 2.0975407
430R:R:Q690 6.235229
431R:R:P703 4.81409
432R:R:K707 5.0925402
433R:R:P711 2.2675495
434R:R:V717 5.005408
435R:R:Y734 6.0725228
436R:R:Y745 3.545407
437R:R:F756 5.9025109
438R:R:M766 6.36754239
439R:R:W773 8.785669
440R:R:V789 2.24355
441R:R:Q790 12.504567
442R:R:S799 3.7575478
443R:R:L806 4.9275478
444R:R:K813 7.0925409
445S:S:L26 5.28615
446S:S:L28 3.8625414
447S:S:G30 3.675419
448S:S:L32 3.56415
449S:S:L34 5.07286717
450S:S:G35 2.1475419
451S:S:G36 2.78518
452S:S:L37 3.996516
453S:S:F38 5.77429718
454S:S:P39 3.75667615
455S:S:H41 5.29143718
456S:S:K43 5.605413
457S:S:R57 8.89333614
458S:S:Q60 10.1075417
459S:S:R61 6.414551114
460S:S:L62 3.74667615
461S:S:E63 6.05571718
462S:S:M65 5.1719
463S:S:L66 4.92667615
464S:S:F67 8.248517
465S:S:L69 4.2416
466S:S:R71 7.552517
467S:S:I72 5.37419
468S:S:L78 6.474517
469S:S:V82 5.1625415
470S:S:R83 6.83417
471S:S:H87 6.32414
472S:S:I88 4.81429717
473S:S:L89 9.445415
474S:S:D90 4.858519
475S:S:S91 4.435416
476S:S:C92 5.955418
477S:S:T96 5.92412
478S:S:H97 5.68167613
479S:S:L99 6.074515
480S:S:Q101 5.99515
481S:S:L103 5.835415
482S:S:F105 7.424516
483S:S:I140 4.35333617
484S:S:G141 2.6475418
485S:S:G142 2.735415
486S:S:S143 6.586514
487S:S:Y144 10.26513
488S:S:S145 3.955418
489S:S:D146 5.505415
490S:S:V147 3.83514
491S:S:S148 3.31833617
492S:S:I149 5.9775405
493S:S:V151 3.8225405
494S:S:N153 4.9175415
495S:S:R156 5.81615
496S:S:L157 6.176515
497S:S:F158 6.99333616
498S:S:I160 5.4825416
499S:S:P161 4.172519
500S:S:Q162 8.175408
501S:S:I163 4.902517
502S:S:Y165 7.95333618
503S:S:A166 3.842515
504S:S:S167 4.264518
505S:S:T168 4.72517
506S:S:L172 6.48517
507S:S:Y178 7.45506
508S:S:Y180 8.16416
509S:S:F181 8.94571719
510S:S:A182 2.9525416
511S:S:R183 8.13667619
512S:S:T184 3.42409
513S:S:V185 5.3475407
514S:S:P186 4.232518
515S:S:P187 5.29714717
516S:S:D188 5.17518
517S:S:F189 5.98413
518S:S:F190 5.21515
519S:S:Q191 9.134518
520S:S:K193 7.675413
521S:S:M195 4.0875417
522S:S:E197 6.156516
523S:S:L199 3.64616
524S:S:R200 3.998514
525S:S:F201 4.3125415
526S:S:F202 5.9925818
527S:S:W204 6.08857719
528S:S:Y206 6.085619
529S:S:S208 3.1575418
530S:S:T209 4.535416
531S:S:S212 4.0675416
532S:S:Y216 9.385617
533S:S:T219 3.428514
534S:S:I221 4.485405
535S:S:F224 4.64833617
536S:S:R231 5.17143714
537S:S:I233 3.0925416
538S:S:E239 3.54405
539S:S:V241 4.976516
540S:S:R243 6.382512
541S:S:M245 7.0225413
542S:S:F250 8.808513
543S:S:E251 6.815412
544S:S:V254 2.494515
545S:S:A263 2.3025417
546S:S:V265 5.4475418
547S:S:V267 6.5925416
548S:S:F269 4.78667617
549S:S:T270 3.4575414
550S:S:R271 7.70375815
551S:S:D274 5.34614
552S:S:L279 5.8075415
553S:S:S282 2.805414
554S:S:R284 8.69413
555S:S:A287 2.3325414
556S:S:F289 6.2775416
557S:S:W291 7.10875817
558S:S:D295 5.69833618
559S:S:W297 5.643641116
560S:S:L300 4.9075415
561S:S:V303 3.822514
562S:S:V304 6.1825414
563S:S:S307 2.6875413
564S:S:A311 2.95416
565S:S:E312 4.115405
566S:S:I315 4.9125415
567S:S:T316 4.8417
568S:S:I317 5.5075416
569S:S:E318 5.234516
570S:S:L319 5.4225414
571S:S:Y322 7.5125413
572S:S:I324 4.0525416
573S:S:D326 3.6475414
574S:S:F327 6.03667918
575S:S:Y330 6.55618
576S:S:F331 7.54667616
577S:S:P336 10.37416
578S:S:W337 5.344513
579S:S:N339 5.468514
580S:S:R341 7.298514
581S:S:N342 6.244517
582S:S:P343 8.3625412
583S:S:W344 7.68143714
584S:S:F345 7.33429714
585S:S:F348 6.944506
586S:S:W349 7.8625818
587S:S:F353 11.284517
588S:S:C355 5.1325418
589S:S:F357 7.55167613
590S:S:F372 7.665615
591S:S:Q374 7.124515
592S:S:E375 8.145415
593S:S:K377 4.82667613
594S:S:I378 6.255617
595S:S:M379 8.36418
596S:S:F380 6.14833616
597S:S:V381 5.3325417
598S:S:V382 4.036518
599S:S:N383 6.66418
600S:S:V385 3.834519
601S:S:Y386 5.885816
602S:S:A387 2.326518
603S:S:M395 3.632515
604S:S:L406 4.915412
605S:S:M410 4.506512
606S:S:N414 5.57414
607S:S:L418 5.5575417
608S:S:Y419 4.97857715
609S:S:D421 3.7825415
610S:S:F422 5.44375814
611S:S:V426 4.3575417
612S:S:F428 8.982518
613S:S:A430 2.74514
614S:S:P431 4.36333617
615S:S:F432 4.99714714
616S:S:R433 4.606513
617S:S:V441 6.1175416
618S:S:F443 5.52667618
619S:S:D444 3.1725418
620S:S:F446 6.155417
621S:S:G447 2.08417
622S:S:D448 6.1875817
623S:S:R452 4.4475404
624S:S:Y453 6.15429718
625S:S:I455 4.0575418
626S:S:F456 6.414515
627S:S:T457 4.328518
628S:S:Y458 9.30667615
629S:S:L459 4.272516
630S:S:R467 5.3275412
631S:S:Y468 6.90143714
632S:S:V471 4.655617
633S:S:W474 7.365616
634S:S:L478 4.15333616
635S:S:L480 4.23516
636S:S:I485 5.86143717
637S:S:W487 5.84875817
638S:S:A488 3.805411
639S:S:V509 4.2054186
640S:S:P514 3.75405
641S:S:E516 5.9045334
642S:S:C518 4.11254339
643S:S:Y528 7.0956138
644S:S:E529 3.8954138
645S:S:C540 4.92254199
646S:S:L586 2.236505
647S:S:F589 3.82667689
648S:S:G612 1.905408
649S:S:Y617 7.5375408
650S:S:M619 3.8225407
651S:S:I624 4.244417
652S:S:P627 3409
653S:S:R635 6.99508
654S:S:R636 6.684297118
655S:S:L637 4.10754244
656S:S:F643 6.2525148
657S:S:C646 2.165406
658S:S:Y647 15.882586
659S:S:L651 6.358589
660S:S:K653 9.51333689
661S:S:R656 4.642508
662S:S:C683 2.986507
663S:S:V694 1.85406
664S:S:W697 7.033336117
665S:S:G704 2.1554114
666S:S:C721 6.144119
667S:S:R724 5.081676118
668S:S:L732 2.7185148
669S:S:L741 4.075484
670S:S:C742 7.8175489
671S:S:Y745 2.6375487
672S:S:E758 9.0575489
673S:S:I762 5.84589
674S:S:M766 4.87667689
675S:S:W773 4.6345149
676S:S:F776 6.315149
677S:S:I779 4.15754387
678S:S:Y787 6.354505
679S:S:F810 4.185489
680S:S:K813 4.158589
681W:W:?902 9.2251260
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:Y105 34.81753.52NoYes056
2B:B:D83 B:B:L69 23.2155.43YesNo085
3A:A:S16 B:B:N88 10.34142.98NoYes077
4B:B:H91 B:B:V133 23.20438.3YesYes554
5B:B:I93 B:B:P94 19.36951.69YesNo075
6B:B:K78 B:B:P94 15.49810.04YesNo085
7A:A:D20 B:B:K89 10.347911.06NoYes069
8A:A:F196 A:A:V34 1003.93YesYes475
9A:A:L36 A:A:V34 1004.47YesYes475
10A:A:I222 A:A:L36 1007.14YesYes477
11A:A:C224 A:A:I222 1001.64YesYes477
12A:A:C224 A:A:S44 1001.72YesNo479
13A:A:G40 A:A:S44 1001.86NoNo099
14A:A:G40 A:A:L39 1001.71NoYes099
15A:A:L39 A:A:W211 1002.28YesYes399
16A:A:Q204 A:A:W211 10010.95YesYes399
17A:A:Q204 B:B:Y145 1002.25YesYes398
18B:B:M101 B:B:Y145 1005.99NoYes098
19B:B:G116 B:B:M101 1001.75NoNo099
20B:B:D118 B:B:G116 1001.68NoNo099
21B:B:D118 B:B:S97 85.08588.83NoNo098
22B:B:L95 B:B:S97 69.6143YesNo588
23B:B:L95 B:B:Y124 65.74898.21YesYes586
24B:B:V133 B:B:Y124 34.80513.79YesYes546
25A:A:F196 A:A:V339 1003.93YesNo078
26A:A:L36 A:A:V339 1004.47YesNo078
27A:A:F189 A:A:F196 10011.79NoYes097
28A:A:F189 A:A:M198 1002.49NoYes097
29A:A:L38 A:A:M198 1002.83YesYes487
30A:A:K46 A:A:L38 1002.82NoYes498
31A:A:K46 A:A:S44 1006.12NoNo499
32A:A:S206 A:A:W211 1002.47YesYes389
33A:A:S206 B:B:Y145 1006.36YesYes388
34A:A:W211 B:B:L117 1002.28YesNo099
35B:B:L117 B:B:Y145 1003.52NoYes098
36B:B:D118 B:B:I120 81.222111.2NoYes096
37B:B:I120 B:B:S122 69.61953.1YesNo568
38B:B:S122 B:B:Y124 65.75245.09NoYes586
39B:B:Q75 B:B:W99 1008.76NoYes299
40B:B:Q75 B:B:Y59 10018.04NoYes298
41A:A:C214 B:B:M101 19.47311.62NoNo079
42A:A:F215 B:B:W99 10010.02NoYes099
43A:A:L37 A:A:L39 1004.15NoYes099
44A:A:F223 A:A:L39 76.71972.44YesYes399
45A:A:C224 A:A:F267 1005.59YesYes479
46A:A:F307 A:A:M243 29.43432.49YesNo388
47A:A:F250 A:A:F307 42.01624.29YesYes398
48A:A:F223 A:A:F250 79.45678.57YesYes399
49A:A:F307 A:A:L266 42.01473.65YesYes389
50A:A:F223 A:A:L266 67.96482.44YesYes399
51A:A:L268 A:A:T321 13.10334.42NoYes085
52A:A:L266 A:A:T321 23.60697.37YesYes095
53B:B:H142 B:B:N119 14.18323.83YesYes399
54B:B:H142 B:B:W169 32.8847.41YesYes398
55B:B:I157 B:B:W169 29.02622.35YesYes378
56B:B:F151 B:B:I157 13.57417.58YesYes397
57B:B:A106 B:B:F151 11.68084.16NoYes369
58A:A:F191 A:A:V332 10010.49YesNo457
59A:A:V332 A:A:V335 1003.21NoNo078
60A:A:F267 A:A:V335 1002.62YesNo098
61A:A:F191 A:A:F336 1007.5YesYes458
62A:A:F196 A:A:F336 1006.43YesYes478
63A:A:Q204 B:B:G144 33.53151.64YesYes098
64B:B:D163 B:B:H142 14.18197.56YesYes399
65B:B:L146 B:B:S161 35.4713YesYes379
66A:A:K210 B:B:Y145 1005.97YesYes398
67B:B:D186 B:B:Y145 34.83382.3YesYes398
68B:B:S147 B:B:Y145 1007.63NoYes098
69A:A:K210 B:B:D228 1002.77YesYes399
70A:A:C214 A:A:H213 17.47744.42NoYes078
71B:B:G64 B:B:Y105 11.78214.35NoYes056
72B:B:L70 B:B:W63 58.206612.53YesYes257
73B:B:L70 B:B:M61 83.9865.65YesYes056
74B:B:C317 B:B:M61 1003.24YesYes076
75B:B:C317 B:B:S316 1003.44YesNo279
76B:B:S316 B:B:W332 1004.94NoYes299
77B:B:A328 B:B:W63 58.14332.59NoYes257
78B:B:A328 B:B:M61 87.85863.22NoYes056
79A:A:H213 B:B:R314 11.621311.28YesYes288
80B:B:K57 B:B:W332 10018.57YesYes299
81A:A:L283 A:A:Y287 45.54544.69YesYes377
82A:A:M243 A:A:Y287 23.41493.59NoYes387
83A:A:M247 A:A:Y287 35.12363.59YesYes367
84A:A:F307 A:A:M247 49.40124.98YesYes386
85A:A:L310 A:A:M247 24.70144.24NoYes046
86A:A:F250 A:A:L310 27.29962.44YesNo094
87A:A:M247 A:A:Q306 35.0815.44YesNo365
88A:A:L348 R:R:I660 1005.71YesYes1099
89A:A:I344 R:R:I660 1005.89NoYes069
90A:A:I344 R:R:A664 1003.25NoNo067
91A:A:T340 R:R:A664 1003.36NoNo067
92A:A:F336 A:A:T340 1005.19YesNo086
93A:A:L283 A:A:Y290 39.94524.69YesYes377
94A:A:Q306 A:A:Y302 31.182912.4NoNo056
95A:A:Y290 A:A:Y302 23.387215.89YesNo076
96A:A:G292 A:A:Y290 10.55522.9NoYes377
97A:A:E298 A:A:Y290 42.22094.49YesYes347
98A:A:E298 A:A:S293 21.11054.31YesNo043
99A:A:E298 A:A:T295 10.55537.06YesNo045
100A:A:L348 A:A:L353 1005.54YesNo1097
101R:R:F756 R:R:I660 16.61333.77YesYes1099
102A:A:L353 R:R:R656 1006.07NoYes1078
103B:B:T321 B:B:W63 90.63689.7YesYes277
104B:B:G324 B:B:T321 77.75691.82YesYes297
105B:B:D254 B:B:N239 50.3712.69YesYes292
106B:B:D254 B:B:L261 38.787613.57YesNo095
107B:B:L261 G:G:V30 34.90894.47NoNo058
108B:B:L30 G:G:V30 27.15142.98YesNo058
109B:B:N237 G:G:Y40 11.722613.96YesYes256
110B:B:N237 B:B:N239 58.049613.62YesYes252
111B:B:L30 G:G:S31 11.636410.51YesNo2759
112B:B:L252 B:B:Y264 29.02324.69YesYes275
113B:B:M262 B:B:Y264 36.75034.79NoYes045
114B:B:F278 B:B:L285 15.50897.31YesYes276
115B:B:G324 G:G:D48 54.28691.68YesYes299
116B:B:S281 G:G:D48 28.45115.89YesYes299
117B:B:R283 B:B:S281 20.69522.64YesYes299
118B:B:L300 B:B:R283 30.94889.72YesYes269
119B:B:L300 B:B:T34 23.21522.95YesYes265
120B:B:M262 B:B:T34 34.81599.03NoYes045
121G:G:D48 G:G:L51 23.27039.5YesNo096
122B:B:R283 G:G:L51 20.69134.86YesNo096
123B:B:D298 B:B:R283 63.25537.15NoYes099
124B:B:D298 B:B:K301 36.1464.15NoNo095
125B:B:K301 B:B:P39 18.0731.67NoNo051
126B:B:D298 B:B:V40 18.0734.38NoNo093
127B:B:G324 G:G:L50 10.37991.71YesYes299
128B:B:I338 B:B:R48 12.9245.01YesYes257
129B:B:D66 B:B:G64 12.91911.68NoNo085
130B:B:D66 B:B:R68 10.33044.76NoYes085
131B:B:S84 G:G:F61 11.63472.64NoYes258
132B:B:I338 G:G:F61 11.63295.02YesYes258
133B:B:L70 B:B:W82 11.68572.28YesYes259
134B:B:S331 B:B:V315 15.49791.62NoYes297
135B:B:L336 B:B:L51 15.51549.69YesYes279
136B:B:H54 B:B:W82 11.65587.41YesYes299
137B:B:H54 B:B:S74 10.36129.76YesNo099
138B:B:H54 B:B:I58 37.48269.28YesYes299
139B:B:I80 B:B:K89 10.33717.27YesYes289
140B:B:G330 B:B:L336 18.0991.71YesYes257
141B:B:C148 B:B:S147 1001.72YesNo069
142B:B:C148 B:B:R150 15.47696.96YesYes366
143B:B:S67 B:B:W63 12.92342.47YesYes257
144B:B:V112 B:B:Y105 54.16532.52NoYes586
145B:B:V112 B:B:Y124 65.76323.79NoYes586
146B:B:C121 B:B:I123 18.0791.64YesYes386
147B:B:I157 B:B:I171 13.55485.89YesNo376
148B:B:C148 B:B:S160 1001.72YesYes366
149B:B:C148 B:B:L190 1003.17YesYes365
150B:B:L192 B:B:R150 11.60676.07YesYes356
151B:B:L190 B:B:L192 11.6192.77YesYes355
152B:B:L152 B:B:L192 19.35385.54YesYes335
153B:B:I171 B:B:N155 15.53234.25NoNo063
154B:B:D170 B:B:N155 12.95165.39NoNo093
155B:B:F199 B:B:L190 36.75597.31YesYes395
156B:B:C166 B:B:S160 29.01073.44YesYes386
157B:B:S160 B:B:S201 87.00441.63YesYes369
158B:B:L190 B:B:S201 87.03214.5YesYes359
159B:B:C166 B:B:F180 23.2064.19YesYes387
160B:B:F180 B:B:F199 23.20710.72YesYes379
161B:B:D186 B:B:G185 27.09421.68YesNo395
162B:B:D205 B:B:G185 23.22425.03YesNo395
163B:B:D205 B:B:H183 13.55475.04YesYes399
164B:B:D170 B:B:T173 10.34634.34NoYes095
165B:B:G202 B:B:S201 1001.86YesYes069
166B:B:G238 B:B:N237 92.95023.39NoYes075
167B:B:F234 B:B:G238 96.81634.52YesNo057
168B:B:I232 B:B:S191 11.61223.1YesNo1288
169B:B:F234 B:B:V200 1002.62YesYes1256
170B:B:G202 B:B:S189 11.60531.86YesNo067
171B:B:L210 B:B:V200 19.38982.98YesYes056
172B:B:E215 B:B:G216 30.96881.64YesNo034
173B:B:D212 B:B:E215 19.387612.99NoYes093
174B:B:A208 B:B:V200 1001.7YesYes1266
175B:B:D228 B:B:S227 81.22612.94YesYes396
176B:B:S227 B:B:S245 75.4453.26YesNo069
177B:B:I229 B:B:S245 30.963.1NoNo079
178B:B:I273 B:B:V276 17.41833.07YesYes266
179B:B:G244 B:B:I273 19.45887.05NoYes056
180B:B:G244 B:B:T243 23.32351.82NoYes058
181B:B:A287 B:B:G288 54.20811.95YesYes267
182B:B:F241 B:B:T243 23.24492.59YesYes1268
183B:B:H225 B:B:S245 42.561112.55YesNo099
184B:B:H225 B:B:T243 29.04175.48YesYes098
185B:B:I229 B:B:T243 29.064.56NoYes078
186B:B:F222 B:B:F241 11.619111.79NoYes1286
187B:B:D228 B:B:D246 1005.32YesYes399
188B:B:C271 B:B:G272 1001.96NoNo054
189B:B:D246 B:B:G272 1003.35YesNo094
190B:B:C271 B:B:D291 1007.78NoYes058
191B:B:L285 B:B:W297 17.43094.56YesYes268
192B:B:W297 B:B:Y289 1009.65YesYes287
193B:B:A287 B:B:Y289 58.0144YesYes267
194B:B:D291 B:B:N293 25.15285.39YesNo085
195B:B:R304 B:B:W297 15.49854YesYes258
196B:B:R304 B:B:V307 15.47885.23YesNo253
197B:B:A305 B:B:G306 15.48911.95NoNo044
198B:B:G306 B:B:R304 19.35693NoYes045
199B:B:C294 B:B:T329 13.54721.69YesYes258
200B:B:T329 B:B:V315 13.54723.17YesYes287
201B:B:T329 B:B:W339 15.47958.49YesYes289
202G:G:F61 G:G:N59 12.93884.83YesNo089
203R:R:L605 R:R:R656 1004.86YesYes088
204R:R:L605 R:R:T652 1007.37YesNo087
205R:R:C683 R:R:T652 1001.69YesNo077
206R:R:C683 R:R:S648 1001.72YesNo079
207R:R:I687 R:R:S648 1003.1NoNo079
208R:R:I687 R:R:L691 1002.85NoNo075
209R:R:L691 R:R:T641 1002.95NoYes056
210R:R:G638 R:R:T641 1003.64NoYes066
211R:R:G638 R:R:M619 1001.75NoYes067
212R:R:M619 R:R:R635 1003.72YesYes678
213R:R:P627 R:R:R635 1004.32YesYes698
214R:R:L719 R:R:P627 1008.21NoYes679
215R:R:K707 R:R:L719 1004.23YesNo027
216R:R:K707 R:R:V717 1007.59YesYes028
217R:R:E555 R:R:V717 1007.13NoYes038
218R:R:E555 R:R:W545 1002.18NoYes036
219R:R:W545 R:R:Y528 1001.93YesYes068
220R:R:E529 R:R:Y528 1006.73YesYes988
221R:R:C525 R:R:E529 1003.04NoYes998
222R:R:C525 R:R:K510 10011.32NoYes997
223R:R:I523 R:R:K510 10011.63YesYes947
224R:R:I523 R:R:P524 1001.69YesNo043
225R:R:P524 R:R:V509 1008.84NoNo036
226R:R:C504 R:R:V509 1005.12YesNo2096
227R:R:C504 R:R:E502 1001.52YesNo094
228R:R:E502 R:R:P503 1001.57NoNo045
229R:R:P503 R:R:R499 1005.76NoNo055
230R:R:R499 R:R:T205 1002.59NoNo057
231R:R:R200 R:R:T205 1003.88YesNo047
232R:R:I233 R:R:R200 1002.51YesYes064
233R:R:I233 R:R:L199 1002.85YesYes166
234R:R:F224 R:R:L199 1002.44YesYes176
235R:R:F224 R:R:F269 1002.14YesYes177
236R:R:F269 R:R:Y216 1003.09YesYes177
237L:L:?901 R:R:Y216 10024.68YesYes107
238R:R:Q679 R:R:R656 10018.69NoYes088
239R:R:Q679 R:R:T652 1005.67NoNo087
240R:R:C537 R:R:E529 1009.12NoYes998
241R:R:C537 R:R:K510 1003.23NoYes997
242R:R:I233 R:R:V207 1003.07YesYes168
243R:R:F224 R:R:V207 1002.62YesYes178
244L:L:?901 R:R:R57 26.702417.9YesYes104
245R:R:F269 R:R:S294 27.12015.28YesNo178
246R:R:G296 R:R:S294 26.69551.86NoNo158
247R:R:G296 R:R:R57 26.2623NoYes154
248L:L:?901 R:R:R61 1008.52YesYes104
249L:L:?901 R:R:S143 35.06722.11YesYes104
250L:L:?901 R:R:Y144 39.64234.11YesYes103
251R:R:S145 R:R:Y216 1005.09NoYes187
252L:L:?901 R:R:A166 27.7035.53YesYes105
253L:L:?901 R:R:R271 95.82852.56YesYes105
254R:R:I233 R:R:R231 89.13412.51YesYes164
255R:R:K193 R:R:R231 43.32436.19YesYes134
256R:R:K193 R:R:W474 43.32465.8YesYes136
257R:R:W474 R:R:Y453 44.30471.93YesYes168
258R:R:E197 R:R:R231 44.61819.3YesYes164
259R:R:E197 R:R:W474 43.205915.27YesYes166
260R:R:L319 R:R:Y453 33.407510.55YesYes148
261R:R:S145 R:R:S169 1006.52NoYes087
262R:R:K171 R:R:S169 1006.12YesYes037
263R:R:K171 R:R:R177 1002.48YesYes135
264R:R:R177 S:S:R243 1002.13YesYes152
265S:S:R243 S:S:R271 10010.66YesYes125
266M:M:?901 S:S:R271 1002.56YesYes105
267R:R:F269 R:R:G220 1009.03YesNo176
268R:R:G220 R:R:T219 1001.82NoNo164
269R:R:S169 R:R:T219 1003.2YesNo074
270M:M:?901 S:S:R57 36.558518.75YesYes104
271M:M:?901 S:S:R61 1007.67YesYes104
272M:M:?901 S:S:T168 42.64775.17YesYes107
273M:M:?901 S:S:K377 60.83769.89YesYes103
274R:R:R61 R:R:Y165 27.34163.09YesYes148
275R:R:G141 R:R:Y165 45.53835.79YesYes188
276R:R:G141 R:R:L37 13.04291.71YesNo086
277R:R:L37 R:R:Q101 23.46362.66NoYes065
278R:R:S143 R:R:Y165 27.26456.36YesYes148
279R:R:A166 R:R:Y165 27.30492.67YesYes158
280R:R:L37 R:R:S91 13.02524.5NoYes066
281R:R:V147 R:R:Y144 30.8153.79YesYes143
282R:R:K43 R:R:R271 57.53782.48YesYes135
283R:R:K43 R:R:K94 52.0552.87YesYes133
284R:R:F38 R:R:R61 39.58842.14YesYes184
285R:R:F38 R:R:I88 25.010312.56YesYes187
286R:R:F105 R:R:G36 13.9023.01YesYes168
287R:R:G141 R:R:G36 15.73372.11YesYes188
288R:R:G141 R:R:V139 15.62091.84YesYes187
289R:R:F105 R:R:V139 10.41473.93YesYes167
290R:R:I88 R:R:L62 12.05298.56YesYes175
291R:R:I378 R:R:R61 59.21742.51YesYes174
292R:R:F327 R:R:I378 45.524215.07YesYes187
293R:R:F327 R:R:Y330 13.13292.06YesYes188
294R:R:F38 R:R:M65 14.63857.46YesYes189
295R:R:L69 R:R:M65 13.3262.83NoYes069
296R:R:L69 R:R:L84 12.87364.15NoYes069
297R:R:L79 R:R:L84 10.23575.54YesYes099
298R:R:I140 R:R:Y165 35.23282.42YesYes178
299R:R:I140 R:R:M388 29.93055.83YesYes176
300R:R:M388 R:R:P161 22.15391.68YesYes169
301R:R:L418 R:R:P161 28.20874.93YesYes179
302R:R:F190 R:R:W474 41.20918.02YesYes156
303R:R:F190 R:R:P187 37.86377.22YesYes157
304R:R:P187 R:R:R183 17.33985.76YesYes179
305R:R:F181 R:R:R183 15.08926.41YesYes199
306R:R:P161 R:R:Y419 14.82942.78YesYes195
307R:R:D448 R:R:P187 18.97929.66YesYes177
308R:R:D448 R:R:G447 17.36421.68YesNo177
309R:R:A182 R:R:G447 11.231.95YesNo167
310R:R:F327 R:R:F331 28.02936.43YesYes186
311R:R:L300 R:R:R57 33.89824.86YesYes154
312R:R:H56 R:R:L300 16.50835.14YesYes035
313R:R:E55 R:R:H56 34.70512.46YesYes053
314R:R:E375 R:R:R57 17.349511.63NoYes154
315R:R:E375 R:R:H56 24.794216NoYes053
316R:R:L300 R:R:S302 14.73336.01YesNo151
317R:R:E55 R:R:S302 13.91832.87YesNo151
318R:R:E55 R:R:F348 39.50912.33YesYes156
319R:R:F345 R:R:F348 31.24844.29YesYes146
320R:R:E63 R:R:F345 11.87214.66YesYes184
321R:R:F380 R:R:L319 32.39978.53YesYes164
322R:R:F380 R:R:T184 16.161510.38YesYes069
323R:R:N383 R:R:P431 14.75714.89YesYes087
324R:R:P431 R:R:Y386 12.082523.64YesYes176
325R:R:F380 R:R:M379 16.5637.46YesYes068
326R:R:L78 R:R:Y386 14.43142.34YesYes176
327R:R:K94 R:R:T96 50.18236.01YesNo032
328R:R:D146 R:R:R271 26.13583.57YesYes155
329R:R:D95 R:R:V147 25.12122.92YesYes144
330R:R:D146 R:R:D95 24.770915.97YesYes154
331R:R:D95 R:R:Q150 14.021410.44YesNo145
332R:R:D95 S:S:R177 35.00764.76YesNo045
333R:R:T96 S:S:R156 44.48819.06NoYes025
334R:R:L99 R:R:Q150 12.23319.32YesNo155
335R:R:D104 R:R:Q101 10.61075.22NoYes045
336S:S:F158 S:S:L157 15.78832.44YesYes165
337R:R:K171 R:R:Y178 34.53514.78YesYes136
338R:R:N153 R:R:Y178 33.93319.3YesYes156
339R:R:N153 S:S:L99 18.25074.12YesYes155
340R:R:L157 S:S:L99 14.82482.77YesYes155
341R:R:N153 S:S:Q150 10.513615.85YesNo155
342R:R:R177 S:S:D95 71.07697.15YesNo054
343S:S:D95 S:S:T96 56.49775.78NoYes042
344R:R:R177 S:S:E213 55.66213.49YesNo056
345R:R:L199 R:R:V267 45.20652.98YesYes166
346R:R:V207 R:R:V265 39.23533.21YesYes188
347R:R:S498 R:R:V265 38.84463.23NoYes098
348R:R:A263 R:R:S498 25.14171.71YesNo079
349R:R:A263 R:R:Y206 22.30782.67YesYes1779
350R:R:C500 R:R:Y206 21.23165.38NoYes099
351R:R:F224 R:R:T209 90.00652.59YesYes176
352R:R:I221 R:R:T209 1003.04YesYes056
353R:R:T209 R:R:V267 44.99343.17YesYes166
354R:R:F269 R:R:I221 87.96287.54YesYes075
355R:R:R264 R:R:S498 13.68212.64NoNo069
356R:R:F289 R:R:R264 13.48142.14NoNo066
357R:R:A211 R:R:I221 1003.25NoYes055
358R:R:A211 R:R:G217 1001.95NoNo058
359R:R:E218 R:R:G217 1001.64NoNo058
360R:R:E218 R:R:K240 10012.15NoNo054
361R:R:K240 S:S:E222 1005.4NoNo046
362S:S:E222 S:S:I221 1004.1NoYes065
363R:R:C500 R:R:C519 21.00587.28NoNo099
364R:R:C518 R:R:C519 20.78881.82NoNo099
365R:R:D295 R:R:E318 21.90116.5YesYes086
366R:R:E318 R:R:F456 16.67962.33YesYes065
367R:R:F331 R:R:L367 11.00484.87YesYes166
368R:R:F345 R:R:P336 52.34852.89YesYes146
369R:R:P336 R:R:W337 48.812814.86YesNo063
370R:R:D335 R:R:W337 34.86632.23NoNo043
371R:R:D335 R:R:S366 20.91981.47NoNo044
372R:R:R368 R:R:S366 13.94661.32NoNo014
373R:R:F348 R:R:R352 10.50538.55YesNo163
374R:R:L418 R:R:M395 21.67944.24YesYes175
375R:R:M395 R:R:M410 15.36814.33YesYes152
376R:R:C400 R:R:M410 13.18191.62YesYes132
377R:R:C518 R:R:E516 20.36293.04NoNo094
378R:R:E516 S:S:E516 18.1576.34NoYes044
379R:R:L610 R:R:T582 10.87352.95YesYes797
380R:R:Q790 W:W:?902 13.20962.03YesYes670
381R:R:Q790 R:R:T793 12.67772.83YesNo078
382R:R:T793 R:R:V789 12.49941.59NoYes085
383R:R:I657 R:R:I660 33.18232.94NoYes099
384R:R:I657 R:R:T749 16.56796.08NoNo098
385R:R:A759 R:R:I657 16.41334.87NoNo099
386R:R:A759 R:R:F756 18.03144.16NoYes099
387R:R:E754 R:R:T749 16.36497.06NoNo088
388R:R:E754 R:R:F661 50.2524.66NoNo089
389R:R:A759 R:R:E754 34.19113.02NoNo098
390R:R:C752 R:R:F661 49.34039.78NoNo089
391R:R:C752 R:R:P753 48.42891.88NoNo089
392R:R:K760 R:R:P753 48.12553.35NoNo099
393R:R:K760 R:R:R750 47.97514.95NoNo099
394R:R:R750 S:S:F761 47.97774.28NoNo095
395S:S:F761 S:S:P812 47.980711.56NoNo059
396S:S:K813 S:S:P812 47.98733.35YesNo099
397S:S:K653 S:S:K813 19.41974.31YesYes899
398S:S:I762 S:S:K653 19.60877.27YesYes899
399S:S:G763 S:S:I762 18.39263.53NoYes899
400S:S:G763 S:S:M766 15.94821.75NoYes899
401R:R:T769 R:R:W773 35.32864.85NoYes089
402R:R:T769 R:R:V804 31.24444.76NoNo087
403R:R:I772 R:R:V804 30.74049.22NoNo087
404R:R:I772 S:S:I771 29.98444.42NoNo088
405R:R:A775 S:S:I771 11.21551.62NoNo078
406R:R:A775 S:S:I772 10.96231.62NoNo078
407R:R:G802 R:R:S801 10.56411.86NoNo089
408R:R:S801 R:R:W773 10.51688.65NoYes099
409R:R:T783 R:R:V789 11.96551.59NoYes075
410R:R:T783 R:R:V782 11.78781.59NoNo078
411R:R:V782 S:S:I779 11.43134.61NoYes3887
412S:S:D49 S:S:T96 54.82644.34NoYes112
413S:S:D49 S:S:H97 53.975912.61NoYes113
414S:S:D90 S:S:H97 19.27632.52YesYes193
415S:S:L89 S:S:Q101 13.885314.64YesYes155
416S:S:F38 S:S:R61 54.07282.14YesYes184
417S:S:F38 S:S:L62 23.60764.87YesYes185
418S:S:F38 S:S:I88 13.06892.51YesYes187
419S:S:I378 S:S:R61 75.80072.51YesYes174
420S:S:F327 S:S:I378 38.390415.07YesYes187
421S:S:R156 S:S:Y180 38.89134.12YesYes156
422S:S:Y180 S:S:Y419 28.40897.94YesYes165
423S:S:P161 S:S:Y419 11.12442.78YesYes195
424S:S:Q159 S:S:Y180 10.10955.64NoYes146
425S:S:F38 S:S:M65 13.1427.46YesYes189
426S:S:I140 S:S:Y165 18.2673.63YesYes178
427S:S:F422 S:S:Y419 11.75954.13YesYes145
428S:S:D146 S:S:D95 14.0016.65YesNo054
429S:S:D146 S:S:V147 26.01445.84YesYes154
430S:S:G142 S:S:V147 12.13161.84YesYes154
431S:S:D146 S:S:R243 13.85695.96YesYes152
432S:S:K43 S:S:R243 10.42038.66YesYes132
433S:S:N54 S:S:P39 13.93281.63NoYes045
434S:S:C50 S:S:H97 13.09872.95NoYes193
435S:S:C50 S:S:H41 12.22934.42NoYes198
436S:S:D90 S:S:H41 12.22473.78YesYes198
437S:S:C92 S:S:H97 13.09877.37YesYes183
438S:S:C92 S:S:H41 12.22932.95YesYes188
439S:S:H41 S:S:V53 10.48996.92YesNo183
440S:S:E347 S:S:H41 23.58729.85NoYes148
441S:S:N54 S:S:Q42 10.44099.24NoNo043
442S:S:I378 S:S:Q60 26.18294.12YesYes177
443S:S:F331 S:S:Q60 20.053318.74YesYes167
444S:S:F331 S:S:F348 12.22523.22YesYes066
445S:S:F327 S:S:F331 20.1295.36YesYes186
446S:S:E213 S:S:G242 54.78693.27NoNo063
447S:S:G242 S:S:M245 53.9233.49NoYes033
448S:S:F250 S:S:M245 51.322913.68YesYes133
449S:S:F250 S:S:L278 97.49957.31YesNo035
450S:S:L278 S:S:W291 94.01874.56NoYes057
451S:S:W291 S:S:W297 29.75156.56YesYes176
452S:S:W297 S:S:Y468 31.32838.68YesYes164
453S:S:E301 S:S:Y468 13.91884.49NoYes134
454S:S:D274 S:S:R271 70.58634.76YesYes145
455S:S:D274 S:S:F250 51.4287.17YesYes143
456S:S:R57 S:S:S272 16.63853.95YesNo142
457S:S:S272 S:S:V303 15.76343.23NoYes124
458S:S:V303 S:S:W297 59.33398.58YesYes146
459S:S:L300 S:S:R57 17.51512.15YesYes154
460S:S:L300 S:S:V303 15.76492.98YesYes154
461S:S:R271 S:S:S212 19.16623.95YesYes156
462S:S:S212 S:S:T270 17.39883.2YesYes164
463S:S:A275 S:S:T270 33.0471.68NoYes054
464S:S:A275 S:S:V303 31.31491.7NoYes054
465S:S:D274 S:S:T270 17.39995.78YesYes144
466S:S:D295 S:S:T168 34.88714.34YesYes187
467S:S:D295 S:S:E318 26.23995.2YesYes186
468S:S:E318 S:S:F456 15.70893.5YesYes165
469S:S:F456 S:S:Y468 10.48077.22YesYes154
470S:S:D295 S:S:K377 35.19562.77YesYes183
471S:S:L62 S:S:N342 17.51362.75YesYes157
472S:S:F345 S:S:N342 13.159610.87YesYes147
473S:S:R177 S:S:Y178 32.423314.4NoYes056
474S:S:A152 S:S:Y178 11.53282.67NoYes076
475S:S:A152 S:S:F181 10.66595.55NoYes079
476S:S:F380 S:S:K377 24.35852.48YesYes163
477S:S:I149 S:S:L172 15.98545.71YesYes057
478S:S:K171 S:S:Y178 10.44443.58NoYes036
479S:S:L172 S:S:R183 12.49933.64YesYes179
480S:S:F380 S:S:M379 16.60477.46YesYes168
481S:S:D295 S:S:Y453 26.41753.45YesYes188
482S:S:W474 S:S:Y453 10.79022.89YesYes168
483S:S:I221 S:S:T209 1007.6YesYes056
484S:S:F224 S:S:T209 1002.59YesYes176
485S:S:F269 S:S:M195 17.44336.22YesYes177
486S:S:T209 S:S:V267 97.01946.35YesYes166
487S:S:D295 S:S:Q191 14.089314.36YesYes188
488S:S:I317 S:S:M195 15.13554.37YesYes167
489S:S:I317 S:S:Q191 18.31839.61YesYes168
490S:S:I317 S:S:Y453 12.31813.63YesYes168
491S:S:F224 S:S:L199 86.43923.65YesYes176
492S:S:I233 S:S:L199 21.72962.85YesYes166
493S:S:I233 S:S:R231 17.2732.51YesYes164
494S:S:L199 S:S:V267 86.43392.98YesYes166
495S:S:L199 S:S:V292 32.32874.47YesNo067
496S:S:L199 S:S:W204 1003.42YesYes169
497S:S:F202 S:S:W204 43.160115.03YesYes189
498S:S:I317 S:S:I455 39.24924.42YesYes168
499S:S:F202 S:S:L480 12.95336.09YesYes186
500S:S:W204 S:S:W487 36.77874.69YesYes197
501S:S:F202 S:S:I485 15.08582.51YesYes187
502S:S:I485 S:S:W487 15.107510.57YesYes177
503S:S:I315 S:S:W204 30.17592.35YesYes159
504S:S:I315 S:S:V292 30.37899.22YesNo057
505S:S:F289 S:S:W291 12.428915.03YesYes167
506S:S:L279 S:S:W291 19.141710.25YesYes157
507S:S:L279 S:S:S307 10.49323YesYes153
508S:S:S282 S:S:W291 24.41536.18YesYes147
509S:S:S282 S:S:V254 15.69031.62YesYes145
510S:S:A311 S:S:W297 20.89962.59YesYes166
511S:S:G313 S:S:W487 10.89262.81NoYes087
512S:S:V304 S:S:W297 20.89963.68YesYes146
513S:S:A311 S:S:Y458 20.90432.67YesYes165
514S:S:V304 S:S:Y458 15.679615.14YesYes145
515S:S:Y458 S:S:Y468 20.928414.89YesYes154
516S:S:E308 S:S:Y458 19.11467.86NoYes145
517S:S:Y458 S:S:Y466 19.294111.91YesNo152
518S:S:I315 S:S:T457 56.11884.56YesYes158
519S:S:M379 S:S:Y322 13.088414.37YesYes183
520S:S:F331 S:S:L367 22.7283.65YesNo166
521S:S:F372 S:S:Q332 10.552211.71YesNo054
522S:S:E347 S:S:E350 20.96643.81NoNo046
523S:S:E350 S:S:F357 18.34593.5NoYes063
524S:S:F357 S:S:W337 10.46017.02YesYes133
525S:S:L367 S:S:W349 13.98614.56NoYes168
526S:S:C355 S:S:W349 13.13932.61YesYes188
527S:S:C355 S:S:D361 10.52196.22YesNo081
528S:S:L480 S:S:V471 10.78642.98YesYes167
529S:S:I485 S:S:V471 21.57079.22YesYes177
530S:S:T457 S:S:V471 21.64586.35YesYes187
531S:S:I455 S:S:V471 32.72363.07YesYes187
532S:S:L459 S:S:T457 26.0424.42YesYes168
533S:S:L484 S:S:V471 34.61034.47NoYes037
534S:S:G472 S:S:V471 34.53281.84NoYes097
535S:S:D481 S:S:G472 17.26641.68NoNo059
536S:S:L484 S:S:S483 17.26643NoNo034
537S:S:F810 S:S:K813 31.65864.96YesYes899
538S:S:F810 S:S:L609 28.30624.87YesNo098
539S:S:C646 S:S:L609 28.00163.17YesNo068
540S:S:C616 S:S:C646 29.88951.82NoYes066
541S:S:C616 S:S:M619 30.35411.62NoYes067
542S:S:F623 S:S:M619 19.65364.98NoYes087
543S:S:F623 S:S:R635 26.493820.31NoYes088
544S:S:P627 S:S:R635 21.20742.88YesYes098
545S:S:L719 S:S:P627 11.67183.28NoYes079
546S:S:L719 S:S:Q558 10.50599.32NoNo074
547S:S:P557 S:S:Q558 10.27273.16NoNo034
548S:S:L556 S:S:P557 10.03951.64NoNo083
549S:S:F623 S:S:M794 10.89578.71NoNo089
550S:S:I739 S:S:M766 16.12735.83NoYes089
551S:S:C770 S:S:I771 18.55231.64NoNo078
552S:S:C770 S:S:I739 18.44731.64NoNo078
553S:S:F780 S:S:M794 10.25966.22NoNo1489
554S:S:I779 S:S:T783 10.90183.04YesNo077
555S:S:Q790 S:S:T783 10.54772.83NoNo077
556S:S:F780 S:S:Q790 10.496514.05NoNo087
557B:B:A299 B:B:L252 25.14031.58NoYes257
558B:B:A299 B:B:L300 23.21751.58NoYes256
559A:A:N294 A:A:S293 10.55531.49NoNo033
560A:A:S16 B:B:K89 15.51084.59NoYes079
561B:B:K89 B:B:W82 31.037615.08YesYes299
562B:B:K57 B:B:Q75 1002.71YesNo299
563B:B:W332 B:B:Y59 1008.68YesYes298
564B:B:G144 B:B:N119 16.12811.7YesYes089
565B:B:D163 B:B:G144 16.7716.71YesYes098
566B:B:C121 B:B:L146 24.51424.76YesYes387
567B:B:H142 B:B:S161 14.194116.74YesYes399
568B:B:L152 B:B:Q156 11.61176.65YesYes335
569B:B:A208 B:B:G202 1001.95YesYes066
570A:A:F215 A:A:L37 1008.53NoNo099
571B:B:G330 B:B:S316 59.44981.86YesNo259
572B:B:G330 B:B:I58 40.06763.53YesYes259
573B:B:L51 B:B:W82 11.628919.36YesYes299
574B:B:H54 B:B:I80 12.922611.93YesYes298
575A:A:G40 A:A:L249 79.08631.71NoNo099
576A:A:F223 A:A:L249 74.59227.31YesNo099
577B:B:L70 B:B:S84 12.92264.5YesNo255
578B:B:I93 B:B:Y124 27.09424.84YesYes576
579B:B:D291 B:B:Y289 1002.3YesYes287
580B:B:N293 B:B:V307 19.34652.96NoNo053
581B:B:G162 B:B:S161 50.95471.86YesYes399
582B:B:A328 B:B:I338 28.42561.62NoYes255
583B:B:W297 B:B:Y264 69.614511.58YesYes285
584B:B:F180 B:B:G216 34.80794.52YesNo374
585A:A:S206 B:B:G162 51.54421.86YesYes389
586B:B:C294 B:B:G288 15.48053.92YesYes257
587B:B:G288 B:B:V315 30.96461.84YesYes277
588B:B:F151 B:B:P107 11.61015.78YesNo396
589B:B:S97 B:B:V100 13.53861.62NoYes589
590B:B:F235 B:B:N237 15.492912.08YesYes265
591B:B:F235 B:B:G282 11.61923.01YesNo269
592R:R:L639 R:R:M619 57.5492.83YesYes687
593R:R:L639 W:W:?902 34.47292.12YesYes680
594R:R:F643 R:R:L639 22.49154.87YesYes688
595R:R:F643 R:R:W773 21.96177.02YesYes689
596R:R:W773 W:W:?902 22.08789.58YesYes690
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?901 S:S:R57 18.75 1 Yes Yes 0 4 0 1
M:M:?901 S:S:R61 7.67 1 Yes Yes 0 4 0 1
M:M:?901 S:S:S143 4.21 1 Yes Yes 0 4 0 1
M:M:?901 S:S:Y144 5.76 1 Yes Yes 0 3 0 1
M:M:?901 S:S:S145 4.21 1 Yes Yes 0 8 0 1
M:M:?901 S:S:A166 5.53 1 Yes Yes 0 5 0 1
M:M:?901 S:S:T168 5.17 1 Yes Yes 0 7 0 1
M:M:?901 S:S:Y216 26.32 1 Yes Yes 0 7 0 1
M:M:?901 S:S:R271 2.56 1 Yes Yes 0 5 0 1
M:M:?901 S:S:K377 9.89 1 Yes Yes 0 3 0 1
S:S:F38 S:S:R61 2.14 1 Yes Yes 8 4 2 1
S:S:F38 S:S:Y165 16.5 1 Yes Yes 8 8 2 2
S:S:F38 S:S:V381 3.93 1 Yes Yes 8 7 2 2
S:S:P39 S:S:R61 2.88 1 Yes Yes 5 4 2 1
S:S:P39 S:S:S93 1.78 1 Yes No 5 1 2 2
S:S:P39 S:S:S143 7.13 1 Yes Yes 5 4 2 1
S:S:P39 S:S:Y144 5.56 1 Yes Yes 5 3 2 1
S:S:K43 S:S:S93 3.06 1 Yes No 3 1 2 2
S:S:K43 S:S:R243 8.66 1 Yes Yes 3 2 2 2
S:S:K43 S:S:R271 4.95 1 Yes Yes 3 5 2 1
S:S:R57 S:S:R61 8.53 1 Yes Yes 4 4 1 1
S:S:R57 S:S:S272 3.95 1 Yes No 4 2 1 2
S:S:G296 S:S:R57 3 0 No Yes 5 4 2 1
S:S:L300 S:S:R57 12.15 1 Yes Yes 5 4 2 1
S:S:E375 S:S:R57 6.98 1 Yes Yes 5 4 2 1
S:S:R61 S:S:S143 10.54 1 Yes Yes 4 4 1 1
S:S:R61 S:S:Y165 7.2 1 Yes Yes 4 8 1 2
S:S:A166 S:S:R61 2.77 1 Yes Yes 5 4 1 1
S:S:E375 S:S:R61 17.45 1 Yes Yes 5 4 2 1
S:S:K377 S:S:R61 4.95 1 Yes Yes 3 4 1 1
S:S:I378 S:S:R61 2.51 1 Yes Yes 7 4 2 1
S:S:R61 S:S:V381 3.92 1 Yes Yes 4 7 1 2
S:S:S93 S:S:Y144 11.45 1 No Yes 1 3 2 1
S:S:S143 S:S:Y165 7.63 1 Yes Yes 4 8 1 2
S:S:A166 S:S:S143 3.42 1 Yes Yes 5 4 1 1
S:S:R271 S:S:Y144 19.55 1 Yes Yes 5 3 1 1
S:S:E273 S:S:Y144 8.98 1 No Yes 1 3 2 1
S:S:S145 S:S:S167 1.63 1 Yes Yes 8 8 1 2
S:S:S145 S:S:S169 4.89 1 Yes No 8 7 1 2
S:S:S145 S:S:Y216 5.09 1 Yes Yes 8 7 1 1
S:S:D146 S:S:R243 5.96 1 Yes Yes 5 2 2 2
S:S:D146 S:S:R271 3.57 1 Yes Yes 5 5 2 1
S:S:A166 S:S:Y165 2.67 1 Yes Yes 5 8 1 2
S:S:V381 S:S:Y165 10.09 1 Yes Yes 7 8 2 2
S:S:A166 S:S:K377 4.82 1 Yes Yes 5 3 1 1
S:S:T168 S:S:V185 4.76 1 Yes Yes 7 7 1 2
S:S:D188 S:S:T168 4.34 1 Yes Yes 8 7 2 1
S:S:T168 S:S:Y216 4.99 1 Yes Yes 7 7 1 1
S:S:D295 S:S:T168 4.34 1 Yes Yes 8 7 2 1
S:S:D188 S:S:S169 2.94 1 Yes No 8 7 2 2
S:S:F380 S:S:V185 7.87 1 Yes Yes 6 7 2 2
S:S:D188 S:S:Y216 9.2 1 Yes Yes 8 7 2 1
S:S:R271 S:S:S212 3.95 1 Yes Yes 5 6 1 2
S:S:D274 S:S:S212 5.89 1 Yes Yes 4 6 2 2
S:S:G217 S:S:Y216 4.35 0 No Yes 8 7 2 1
S:S:S294 S:S:Y216 6.36 0 No Yes 8 7 2 1
S:S:R243 S:S:R271 10.66 1 Yes Yes 2 5 2 1
S:S:E273 S:S:R271 11.63 1 No Yes 1 5 2 1
S:S:D274 S:S:R271 4.76 1 Yes Yes 4 5 2 1
S:S:L300 S:S:S272 3 1 Yes No 5 2 2 2
S:S:D274 S:S:E273 2.6 1 Yes No 4 1 2 2
S:S:D295 S:S:K377 2.77 1 Yes Yes 8 3 2 1
S:S:E375 S:S:K377 4.05 1 Yes Yes 5 3 2 1
S:S:E375 S:S:I378 4.1 1 Yes Yes 5 7 2 2
S:S:F380 S:S:K377 2.48 1 Yes Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?901 R:R:R57 17.9 1 Yes Yes 0 4 0 1
L:L:?901 R:R:R61 8.52 1 Yes Yes 0 4 0 1
L:L:?901 R:R:S143 2.11 1 Yes Yes 0 4 0 1
L:L:?901 R:R:Y144 4.11 1 Yes Yes 0 3 0 1
L:L:?901 R:R:S145 4.21 1 Yes No 0 8 0 1
L:L:?901 R:R:A166 5.53 1 Yes Yes 0 5 0 1
L:L:?901 R:R:T168 5.17 1 Yes Yes 0 7 0 1
L:L:?901 R:R:Y216 24.68 1 Yes Yes 0 7 0 1
L:L:?901 R:R:R271 2.56 1 Yes Yes 0 5 0 1
L:L:?901 R:R:D295 2.86 1 Yes Yes 0 8 0 1
L:L:?901 R:R:G296 3.6 1 Yes No 0 5 0 1
L:L:?901 R:R:K377 6.93 1 Yes Yes 0 3 0 1
R:R:F38 R:R:P39 2.89 1 Yes Yes 8 5 2 2
R:R:F38 R:R:R61 2.14 1 Yes Yes 8 4 2 1
R:R:F38 R:R:Y165 22.69 1 Yes Yes 8 8 2 2
R:R:P39 R:R:S93 1.78 1 Yes No 5 1 2 2
R:R:P39 R:R:S143 7.13 1 Yes Yes 5 4 2 1
R:R:P39 R:R:Y144 6.95 1 Yes Yes 5 3 2 1
R:R:K43 R:R:R243 7.43 1 Yes Yes 3 2 2 2
R:R:K43 R:R:R271 2.48 1 Yes Yes 3 5 2 1
R:R:E273 R:R:K43 4.05 1 Yes Yes 1 3 2 2
R:R:R57 R:R:R61 13.86 1 Yes Yes 4 4 1 1
R:R:R57 R:R:S272 9.22 1 Yes No 4 2 1 2
R:R:G296 R:R:R57 3 1 No Yes 5 4 1 1
R:R:L300 R:R:R57 4.86 1 Yes Yes 5 4 2 1
R:R:E375 R:R:R57 11.63 1 No Yes 5 4 2 1
R:R:R61 R:R:S143 5.27 1 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 3.09 1 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 1 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 1 No Yes 5 4 2 1
R:R:K377 R:R:R61 11.14 1 Yes Yes 3 4 1 1
R:R:I378 R:R:R61 2.51 1 Yes Yes 7 4 2 1
R:R:R61 R:R:V381 3.92 1 Yes No 4 7 1 2
R:R:S93 R:R:Y144 8.9 1 No Yes 1 3 2 1
R:R:R271 R:R:S93 2.64 1 Yes No 5 1 1 2
R:R:S143 R:R:Y165 6.36 1 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 1 Yes Yes 5 4 1 1
R:R:V147 R:R:Y144 3.79 1 Yes Yes 4 3 2 1
R:R:R271 R:R:Y144 22.64 1 Yes Yes 5 3 1 1
R:R:E273 R:R:Y144 3.37 1 Yes Yes 1 3 2 1
R:R:S145 R:R:S169 6.52 1 No Yes 8 7 1 2
R:R:S145 R:R:Y216 5.09 1 No Yes 8 7 1 1
R:R:D146 R:R:V147 2.92 1 Yes Yes 5 4 2 2
R:R:D146 R:R:R243 13.1 1 Yes Yes 5 2 2 2
R:R:D146 R:R:R271 3.57 1 Yes Yes 5 5 2 1
R:R:A166 R:R:Y165 2.67 1 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 8.83 1 No Yes 7 8 2 2
R:R:A166 R:R:K377 3.21 1 Yes Yes 5 3 1 1
R:R:T168 R:R:V185 4.76 1 Yes Yes 7 7 1 2
R:R:D188 R:R:T168 5.78 1 Yes Yes 8 7 2 1
R:R:T168 R:R:Y216 4.99 1 Yes Yes 7 7 1 1
R:R:D295 R:R:T168 4.34 1 Yes Yes 8 7 1 1
R:R:K377 R:R:V185 3.04 1 Yes Yes 3 7 1 2
R:R:F380 R:R:V185 11.8 1 Yes Yes 6 7 2 2
R:R:D188 R:R:Q191 3.92 1 Yes Yes 8 8 2 2
R:R:D188 R:R:Y216 8.05 1 Yes Yes 8 7 2 1
R:R:Q191 R:R:Y216 3.38 1 Yes Yes 8 7 2 1
R:R:D295 R:R:Q191 13.05 1 Yes Yes 8 8 1 2
R:R:Q191 R:R:Y453 18.04 1 Yes Yes 8 8 2 2
R:R:R271 R:R:S212 3.95 1 Yes Yes 5 6 1 2
R:R:D274 R:R:S212 5.89 1 Yes Yes 4 6 2 2
R:R:F269 R:R:Y216 3.09 1 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 8.9 1 No Yes 8 7 2 1
R:R:D295 R:R:Y216 3.45 1 Yes Yes 8 7 1 1
R:R:R243 R:R:R271 19.19 1 Yes Yes 2 5 2 1
R:R:F269 R:R:S294 5.28 1 Yes No 7 8 2 2
R:R:E273 R:R:R271 13.96 1 Yes Yes 1 5 2 1
R:R:D274 R:R:R271 4.76 1 Yes Yes 4 5 2 1
R:R:L300 R:R:S272 3 1 Yes No 5 2 2 2
R:R:D274 R:R:E273 2.6 1 Yes Yes 4 1 2 2
R:R:G296 R:R:S294 1.86 1 No No 5 8 1 2
R:R:D295 R:R:E318 6.5 1 Yes Yes 8 6 1 2
R:R:D295 R:R:L319 5.43 1 Yes Yes 8 4 1 2
R:R:D295 R:R:Y453 4.6 1 Yes Yes 8 8 1 2
R:R:E318 R:R:K377 2.7 0 Yes Yes 6 3 2 1
R:R:K377 R:R:L319 4.23 1 Yes Yes 3 4 1 2
R:R:F380 R:R:L319 8.53 1 Yes Yes 6 4 2 2
R:R:L319 R:R:Y453 10.55 1 Yes Yes 4 8 2 2
R:R:F380 R:R:K377 2.48 1 Yes Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single9B9Y7DY9B9Y-CB1-7DY
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single9BA0A1AKN9BA0-CB1-A1AKN
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F623 R:R:M619 9.95 6 No Yes 8 7 2 2
R:R:L639 R:R:M619 2.83 6 Yes Yes 8 7 1 2
R:R:F623 R:R:L639 2.44 6 No Yes 8 8 2 1
R:R:F623 R:R:M794 4.98 6 No No 8 9 2 2
R:R:G640 R:R:L639 3.42 0 No Yes 6 8 2 1
R:R:F643 R:R:L639 4.87 6 Yes Yes 8 8 1 1
R:R:L639 W:W:?902 2.12 6 Yes Yes 8 0 1 0
R:R:F643 R:R:Y647 7.22 6 Yes Yes 8 6 1 1
R:R:F643 R:R:N735 4.83 6 Yes No 8 7 1 1
R:R:F643 R:R:W773 7.02 6 Yes Yes 8 9 1 1
R:R:F643 W:W:?902 15.83 6 Yes Yes 8 0 1 0
R:R:N735 R:R:Y647 9.3 6 No Yes 7 6 1 1
R:R:L738 R:R:Y647 2.34 0 No Yes 9 6 2 1
R:R:I739 R:R:Y647 7.25 6 No Yes 8 6 2 1
R:R:W773 R:R:Y647 20.26 6 Yes Yes 9 6 1 1
R:R:Y647 W:W:?902 8.96 6 Yes Yes 6 0 1 0
R:R:M728 R:R:N722 4.21 6 No No 7 6 1 2
R:R:D725 R:R:M728 4.16 6 No No 4 7 1 1
R:R:D725 R:R:L729 19 6 No No 4 5 1 2
R:R:D725 W:W:?902 12.45 6 No Yes 4 0 1 0
R:R:M728 W:W:?902 11.89 6 No Yes 7 0 1 0
R:R:L732 R:R:L777 4.15 6 No No 8 7 1 1
R:R:L732 W:W:?902 13.75 6 No Yes 8 0 1 0
R:R:N735 W:W:?902 12.59 6 No Yes 7 0 1 0
R:R:I739 R:R:W773 2.35 6 No Yes 8 9 2 1
R:R:T769 R:R:W773 4.85 0 No Yes 8 9 2 1
R:R:S801 R:R:W773 8.65 0 No Yes 9 9 2 1
R:R:W773 W:W:?902 9.58 6 Yes Yes 9 0 1 0
R:R:L777 R:R:P778 3.28 6 No No 7 8 1 2
R:R:L777 W:W:?902 3.17 6 No Yes 7 0 1 0
R:R:F780 R:R:Q790 14.05 6 No Yes 8 7 1 1
R:R:F780 R:R:M794 7.46 6 No No 8 9 1 2
R:R:F780 W:W:?902 14.89 6 No Yes 8 0 1 0
R:R:Q790 R:R:S784 8.66 6 Yes No 7 6 1 1
R:R:S784 W:W:?902 3.44 6 No Yes 6 0 1 0
R:R:Q790 R:R:Y787 34.95 6 Yes No 7 5 1 2
R:R:Q790 R:R:T793 2.83 6 Yes No 7 8 1 2
R:R:Q790 W:W:?902 2.03 6 Yes Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
53.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
53.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
52.94Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
46.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
46.15Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
44.44Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
43.75Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
43.75Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
42.86Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
41.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
41.18Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
40.00Single3NY9ICI118-5513NY9-β2-ICI118-551
40.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
40.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
40.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
40.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
40.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
40.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
38.89Single5V54Methiothepin5V54-5-HT1B-Methiothepin
38.89Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
38.89Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.89Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Consensus5ht1_offOrthosteric Ligand5ht1b_off
38.89Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
38.89Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
38.89Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
37.50Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
37.50Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
37.50Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
37.50Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
37.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
37.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
36.84Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
36.84Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
36.84Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
36.84Single7YITNalfurafine7YIT-κ-Nalfurafine
36.84Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
36.84Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
36.84Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
35.71Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
35.71Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
35.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
35.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
35.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
35.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
35.29Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
35.29Single8CU6LJ-45178CU6-A2A-LJ-4517
35.29Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
35.29Single8X63Mepyramine8X63-H1-Mepyramine
35.29Single8X64Desloratadine8X64-H1-Desloratadine
35.29Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
35.29Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
35.29Consensushistamine_offOrthosteric Ligandh1_off
35.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
35.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
35.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
35.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
33.33Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
33.33Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
33.33Single6HLPNetupitant6HLP-NK1-Netupitant
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6PS6Timolol6PS6-β2-Timolol
33.33Single6PT3DPI-2876PT3-δ-DPI-287
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
33.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
33.33Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
33.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
33.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
33.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
33.33Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
33.33Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
33.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
31.82Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
31.82Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
31.58Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
31.58Single6E59L-7607356E59-NK1-L-760735
31.58Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
31.58Single6J20Aprepitant6J20-NK1-Aprepitant
31.58Single6J21Aprepitant6J21-NK1-Aprepitant
31.58Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
31.58Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
31.58Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
31.58Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
31.58Single8EA0Iperoxo8EA0-M3-Iperoxo
31.58Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
31.58Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
31.58Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
31.58Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
31.58Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.58Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
31.58Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
31.58Consensusa2_onOrthosteric Liganda2b_on
31.58Consensusa2_on_gpOrthosteric Liganda2b_on_gp
31.58Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
31.58Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
31.58Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
31.25Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
31.25Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
31.25Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
30.77Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
30.43Single3QAKUK-4320973QAK-A2A-UK-432097
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
30.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
30.00Single6A93Risperidone6A93-5-HT2A-Risperidone
30.00Single6CM4Risperidone6CM4-D2-Risperidone
30.00Single7DFPSpiperone7DFP-D2-Spiperone
30.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
30.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
30.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
30.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
30.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
30.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
30.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
30.00Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
30.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
29.41Single3RZECidoxepin3RZE-H1-Cidoxepin
29.41Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
29.41Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.41Single5JTBZM-2413855JTB-A2A-ZM-241385
29.41Single5UVIZM-2413855UVI-A2A-ZM-241385
29.41Single6AQFZM-2413856AQF-A2A-ZM-241385
29.41Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
29.41Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
29.41Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
29.41Single6TPKRetosiban6TPK-OT-Retosiban
29.41Single6TPNHTL66416TPN-OX2-HTL6641
29.41Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
29.41Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.41Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
29.41Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.41Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
29.41Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
29.41Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
29.41Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9BJKNaloxone9BJK-μ-Naloxone-NAM
29.41Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
29.41Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.41Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.41Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
29.41Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.41Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.41Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
29.41Consensusvasop-oxy_offOrthosteric Ligandot_off
29.17Single5WF5UK-4320975WF5-A2A-UK-432097
29.17Single6PT2KGCHM076PT2-δ-KGCHM07
28.57Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.57Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
28.57Single7UM4AS26747237UM4-5-HT5A-AS2674723
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
28.57Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
27.78Single3EMLZM-2413853EML-A2A-ZM-241385
27.78Single3NY8ICI118-5513NY8-β2-ICI118-551
27.78Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
27.78Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
27.78Single4DAJTiotropium4DAJ-M3-Tiotropium
27.78Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
27.78Single4EJ4Naltrindole4EJ4-δ-Naltrindole
27.78Single4GBRS-Carazolol4GBR-β2-S-Carazolol
27.78Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
27.78Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
27.78Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
27.78Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
27.78Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
27.78Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
27.78Single6PS1Timolol6PS1-β2-Timolol
27.78Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
27.78Single6S0LZM-2413856S0L-A2A-ZM-241385
27.78Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
27.78Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.78Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
27.78Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
27.78Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
27.78Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
27.78Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8JJOAlprenolol8JJO-β2-Alprenolol
27.78Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Single8JXRLSD8JXR-D1-LSD
27.78Single8T1WCVN4248T1W-GPR6-CVN424
27.78Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.78Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
27.78Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
27.78Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
27.78Single9CHXS-Carazolol9CHX-β2-S-Carazolol
27.78Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
27.78Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.78Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.78Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.78Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
27.78Consensusalpha2_onOrthosteric Ligandalpha2b_on
27.78Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
27.78Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
27.78Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
27.78Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
27.78Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
27.78Consensusdopamine_offOrthosteric Ligandd2_off d3_off
27.27Single4UG2CGS216804UG2-A2A-CGS21680
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.27Single8IEIA1LYA8IEI-GPR156-A1LYA
27.27Single8X5YAstemizole8X5Y-H1-Astemizole
27.27Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
27.27Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
26.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
26.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
26.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.32Single2RH1S-Carazolol2RH1-β2-S-Carazolol
26.32Single2YCWS-Carazolol2YCW-β1-S-Carazolol
26.32Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
26.32Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
26.32Single5C1MBU725C1M-μ-BU72
26.32Single5D6LS-Carazolol5D6L-β2-S-Carazolol
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5JQHS-Carazolol5JQH-β2-S-Carazolol
26.32Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.32Single5N2SPSB365N2S-A1-PSB36
26.32Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
26.32Single5TVNLSD5TVN-5-HT2B-LSD
26.32Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
26.32Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.32Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.32Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.32Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
26.32Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
26.32Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
26.32Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.32Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
26.32Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
26.32Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
26.32Single7WC6LSD7WC6-5-HT2A-LSD
26.32Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
26.32Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.32Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.32Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
26.32Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
26.32Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
26.32Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8ZMFA1L108ZMF-5-HT2C-A1L10
26.32Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
26.32Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
26.32Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
26.32Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
26.32Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.32Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.32Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.32Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
26.32Consensusamine_offonOrthosteric Ligandamine_off amine_on
26.32Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
26.32Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
26.32Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
26.32Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
26.32Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.32Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
26.32Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
26.32Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
26.09Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
26.09Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
26.09Single8IEBA1LYA8IEB-GPR156-A1LYA
26.09Single8IEPA1LYA8IEP-GPR156-A1LYA
26.09Single8IEPA1LYA8IEP-GPR156-A1LYA
26.09Single8WDTphotoNECA8WDT-A2A-photoNECA
26.09Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
26.09Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
25.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.93Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
25.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
25.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
25.00Single2YDVNECA2YDV-A2A-NECA
25.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
25.00Single3P0GBI1671073P0G-β2-BI167107
25.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
25.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
25.00Single4UHRCGS216804UHR-A2A-CGS21680
25.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
25.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
25.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
25.00Single5G53NECA5G53-A2A-NECA-Gs
25.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6HLOAprepitant6HLO-NK1-Aprepitant
25.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
25.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
25.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.00Single6WGTLSD6WGT-5-HT2A-LSD
25.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
25.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
25.00Single7P2L4YI7P2L-mGlu5-4YI
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
25.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
25.00Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
25.00Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
25.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
25.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8E0GBU728E0G-μ-BU72
25.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
25.00Single8IEBA1LYA8IEB-GPR156-A1LYA
25.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
25.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
25.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
25.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
25.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
25.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
25.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
25.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
25.00Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
25.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
25.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
25.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
25.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
25.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
25.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
24.14Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
24.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
24.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
24.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
23.81Single3D4STimolol3D4S-β2-Timolol
23.81Single4AMIBucindolol4AMI-β1-Bucindolol
23.81Single5CXVTiotropium5CXV-M1-Tiotropium
23.81Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
23.81Single6MXTSalmeterol6MXT-β2-Salmeterol
23.81Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
23.81Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
23.81Single8JJ8Formoterol8JJ8-β2-Formoterol
23.81Single8JJLOlodaterol8JJL-β2-Olodaterol
23.81Single8JWY2-1188JWY-A2A-2-118
23.81Single8JWZAB9288JWZ-A2A-AB928-Na
23.81Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
23.81Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
23.81Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
23.81Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
23.81Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
23.81Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
23.81Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.81Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
23.81Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
23.53Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
23.53Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
23.53Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
23.53Single6B73MP11046B73-κ-MP1104
23.53Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
23.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.53Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
23.53Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
23.53Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
23.53Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
23.53Single7BR3Elagolix7BR3-GnRH1-Elagolix
23.53Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
23.53Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
23.53Single7F8ULintitript7F8U-CCKA-Lintitript
23.53Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
23.53Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.53Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
23.53Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
23.53Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.53Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
23.53Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.53Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
23.53Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
23.53Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
23.53Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.53Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
23.53Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
23.53Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
23.53Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.53Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
23.53Consensusalpha2_offOrthosteric Ligandalpha2c_off
23.53Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
23.53Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
23.53Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
23.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
22.73Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single5X93K-87945X93-ETB-K-8794
22.73Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
22.73Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
22.73Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
22.73Single7EZCUKA7EZC-A2A-UKA
22.73Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
22.73Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
22.73Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
22.73Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
22.73Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
22.73Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
22.73Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
22.73Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
22.73Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.73Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.73Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
22.73Consensusendothelin_offOrthosteric Ligandetb_off
22.73Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
22.73Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
22.22Single2YDOAdenosine2YDO-A2A-Adenosine
22.22Single3REYXAC3REY-A2A-XAC
22.22Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
22.22Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
22.22Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
22.22Single5IUBQ274563445IUB-A2A-Q27456344-Na
22.22Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
22.22Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
22.22Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
22.22Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
22.22Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
22.22Single6A94Zotepine6A94-5-HT2A-Zotepine
22.22Single6MH8ZM-2413856MH8-A2A-ZM-241385
22.22Single6PS0S-Carazolol6PS0-β2-S-Carazolol
22.22Single6PS4ICI118-5516PS4-β2-ICI118-551
22.22Single6PS5S-Propranolol6PS5-β2-S-Propranolol
22.22Single6TPGEMPA6TPG-OX2-EMPA
22.22Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
22.22Single7AROLUF58337ARO-A2A-LUF5833-Na
22.22Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
22.22Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
22.22Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
22.22Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
22.22Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
22.22Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
22.22Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
22.22Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
22.22Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
22.22Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
22.22Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
22.22Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
22.22Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
22.22Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
22.22Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
22.22Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
22.22Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
22.22Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
22.22Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
22.22Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
22.22Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
22.22Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
22.22Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
22.22Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
22.22Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
22.22Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
22.22Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
22.22Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
22.22Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
22.22Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
22.22Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Consensusgrh_offOrthosteric Ligandgnrh1_off
22.22Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
22.22Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
22.22Consensusopsins_offOrthosteric Ligandrhodopsin_off
22.22Consensussensory_offOrthosteric Ligandopsins_off
21.74Single5WF6UK-4320975WF6-A2A-UK-432097
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.74Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
21.74Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
21.74Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
21.43Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.43Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
21.05Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
21.05Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
21.05Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
21.05Single4MQSIperoxo4MQS-M2-Iperoxo
21.05Single4U14Tiotropium4U14-M3-Tiotropium
21.05Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
21.05Single5DHGC-355DHG-NOP-C-35
21.05Single5DHHSB-6121115DHH-NOP-SB-612111
21.05Single5DSGTiotropium5DSG-M4-Tiotropium
21.05Single5UENDU1725UEN-A1-DU172
21.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
21.05Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
21.05Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
21.05Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
21.05Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
21.05Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
21.05Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
21.05Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
21.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
21.05Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
21.05Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
21.05Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
21.05Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
21.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.05Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
21.05Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
21.05Single7WC7Lisuride7WC7-5-HT2A-Lisuride
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
21.05Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
21.05Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
21.05Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
21.05Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
21.05Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
21.05Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
21.05Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
21.05Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
21.05Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
21.05Single8RLNLUF58348RLN-A2A-LUF5834
21.05Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
21.05Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
21.05Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
21.05Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
21.05Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
21.05Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
21.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
21.05Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
21.05Consensus5ht5_onOrthosteric Ligand5ht5a_on
21.05Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
21.05Consensusa3_onOrthosteric Liganda3a_on
21.05Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.05Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
21.05Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
21.05Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
21.05Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
21.05Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
20.83Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
20.83Single4IARErgotamine4IAR-5-HT1B-Ergotamine
20.83Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
20.83Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
20.83Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.69Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.69Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
20.00Single3RFMCaffeine3RFM-A2A-Caffeine
20.00Single5CGCHTL142425CGC-mGlu5-HTL14242
20.00Single5WQCEMPA5WQC-OX2-EMPA
20.00Single5XPRBosentan5XPR-ETB-Bosentan
20.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
20.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
20.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
20.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
20.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
20.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
20.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
20.00Single7W41PD1762527W41-BB2-PD176252
20.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
20.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
20.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
20.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
20.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
20.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
20.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8JXSPF-61428JXS-D1-PF-6142
20.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
20.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
20.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
20.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
20.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
20.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
20.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
20.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
20.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
20.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
20.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
20.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
20.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
20.00Consensusbombesin_offOrthosteric Ligandbb2_off
20.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
20.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
20.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
20.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
20.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
20.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
20.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
20.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensustrace-amine_onOrthosteric Ligandta1_on
19.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.23Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
19.23Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
19.23Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
19.23Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
19.23Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
19.23Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
19.23Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.23Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
19.23Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
19.23Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
19.05Single4DJHJDTic4DJH-κ-JDTic
19.05Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
19.05Single4U15Tiotropium4U15-M3-Tiotropium
19.05Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
19.05Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
19.05Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
19.05Single6H7JIsoprenaline6H7J-β1-Isoprenaline
19.05Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
19.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.05Single6OL9Tiotropium6OL9-M5-Tiotropium
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
19.05Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
19.05Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
19.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
19.05Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
19.05Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
19.05Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
19.05Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
19.05Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
19.05Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
19.05Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
19.05Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.05Single8XVLZibotentan8XVL-ETA-Zibotentan
19.05Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
19.05Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
19.05Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
19.05Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
19.05Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
19.05Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
19.05Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
19.05Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
19.05Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
19.05Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
18.75Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
18.75Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
18.75Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
18.75Single3UZAGTPL92363UZA-A2A-GTPL9236
18.75Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.75Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
18.75Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
18.75Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.75Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
18.75Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
18.75Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.75Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
18.75Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
18.75Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensus5ht2_onOrthosteric Ligand5ht2b_on
18.75Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.75Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
18.52Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
18.52Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
18.18Single4LDEBI1671074LDE-β2-BI167107
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
18.18Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
18.18Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.18Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
18.18Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.18Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
18.18Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
18.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.18Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
18.18Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.18Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
18.18Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
18.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
18.18Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.18Consensusalpha1_offOrthosteric Ligandalpha1a_off
18.18Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
18.18Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
18.18Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
18.18Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
18.18Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
18.18Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
18.18Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
18.18Consensuslpa_offOrthosteric Ligandlpa1_off
18.18Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.18Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
18.18Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
18.18Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
17.86Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.86Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
17.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8ZRTET-18ZRT-ETB-ET-1
17.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.86Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.86Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
17.65Single3PBLEticlopride3PBL-D3-Eticlopride
17.65Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.65Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
17.65Single6HLLCP999946HLL-NK1-CP99994
17.65Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
17.65Single6TP4ACT-4622066TP4-OX1-ACT-462206
17.65Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
17.65Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
17.65Single7SRQLSD7SRQ-5-HT2B-LSD
17.65Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
17.65Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.65Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
17.65Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
17.65Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
17.65Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
17.65Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
17.65Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
17.65Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
17.65Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
17.65Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
17.65Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
17.65Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
17.65Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
17.65Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.39Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.39Single6H7LDobutamine6H7L-β1-Dobutamine
17.39Single6IBLArformoterol6IBL-β1-Arformoterol
17.39Single6K1QIRL25006K1Q-ETB-IRL2500
17.39Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
17.39Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
17.39Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.39Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
17.39Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.39Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
17.39Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
17.39Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
17.39Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
17.39Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.39Single8XVJMacitentan8XVJ-ETA-Macitentan
17.39Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
17.39Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
17.39Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
17.39Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
17.39Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
17.24Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.24Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.24Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
17.24Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
16.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
16.67Single3PWHZM-2413853PWH-A2A-ZM-241385
16.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
16.67Single5ZTYAM102575ZTY-CB2-AM10257
16.67Single6AKXA4R6AKX-CCR5-A4R
16.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
16.67Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6TODEMPA6TOD-OX1-EMPA-Na
16.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
16.67Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.67Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SK9CCX6627SK9-ACKR3-CCX662
16.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
16.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
16.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7XN9L-054,5227XN9-SST2-L-054,522
16.67Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
16.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
16.67Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
16.67Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.67Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
16.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
16.67Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.67Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
16.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
16.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.67Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
16.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
16.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
16.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
16.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
16.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
16.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
16.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
16.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.67Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
16.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
16.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
16.67Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
16.13Single6IGLIRL16206IGL-ETB-IRL1620
16.13Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.13Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.13Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
16.13Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
16.13Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.13Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.13Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.13Consensusbradykinin_onOrthosteric Ligandbk2_on
16.13Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
16.13Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.13Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
16.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.00Single7F8XNN90567F8X-CCKA-NN9056
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7QA8Peptide7QA8-STE2-Peptide
16.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
16.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
16.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
16.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
16.00Single8WKYPG-9348WKY-MC4-PG-934
16.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
16.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
16.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
15.79Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.79Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.79Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single6IQLL7458706IQL-D4-L745870
15.79Single6VI4JDTic6VI4-κ-JDTic
15.79Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
15.79Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.79Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.79Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
15.79Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
15.79Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single7T32ZM-2413857T32-A2A-ZM-241385
15.79Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.79Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.79Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.79Single7VV6C48/807VV6-MRGPRX2-C48/80
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.79Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.79Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.79Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.79Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
15.79Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.79Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
15.79Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
15.79Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
15.79Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
15.79Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.79Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
15.79Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.79Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.79Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
15.79Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.79Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
15.79Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
15.62Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.62Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.62Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.62Consensusbombesin_onOrthosteric Ligandbb2_on
15.62Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
15.62Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.62Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.38Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
15.38Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.38Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
15.38Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
15.38Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
15.38Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
15.38Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.15Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.15Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.15Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
15.15Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
15.15Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.00Single2Y02Carmoterol2Y02-β1-Carmoterol
15.00Single2Y04Salbutamol2Y04-β1-Salbutamol
15.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
15.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
15.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single6H7MSalbutamol6H7M-β1-Salbutamol
15.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
15.00Single6TOTLemborexant6TOT-OX1-Lemborexant
15.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
15.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
15.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
15.00Single7UL4Alvimopan7UL4-μ-Alvimopan
15.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
15.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
15.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
15.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
15.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
15.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
15.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.81Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
14.81Single6W25SHU91196W25-MC4-SHU9119-Ca
14.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
14.81Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
14.81Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.81Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.81Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.71Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
14.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.29Single4NTJAZD12834NTJ-P2Y12-AZD1283
14.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
14.29Single5WIUNemonapride5WIU-D4-Nemonapride
14.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
14.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6TP6Filorexant6TP6-OX1-Filorexant
14.29Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
14.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
14.29Single6Z4SSR486926Z4S-NTS1-SR48692
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
14.29Single7C4SS1P7C4S-S1P3-S1P
14.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
14.29Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.29Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
14.29Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.29Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.29Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
14.29Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
14.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.29Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
14.29Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
14.29Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
14.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
14.29Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
14.29Single8S4DCMF-0198S4D-Apelin-CMF-019
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.29Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
14.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
14.29Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
14.29Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.29Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.29Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
14.29Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
14.29Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
14.29Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.29Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.29Consensusvasop-oxy_onOrthosteric Ligandv2_on
14.29Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
13.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
13.79Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
13.79Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
13.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.79Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
13.79Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
13.79Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
13.79Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.64Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
13.64Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
13.64Single5XR8AM8415XR8-CB1-AM841
13.64Single5XRAAM115425XRA-CB1-AM11542
13.64Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.64Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.64Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
13.64Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
13.64Single7FEECP559407FEE-CB1-CP55940-ZCZ011
13.64Single7R0CAVP7R0C-V2-AVP-Arrestin2
13.64Single7TUYGSK682753A7TUY-GPR183-GSK682753A
13.64Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.64Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
13.64Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
13.64Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
13.64Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
13.64Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
13.64Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.64Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
13.64Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
13.64Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.64Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.64Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
13.64Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
13.64Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.64Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
13.64Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
13.64Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
13.64Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
13.64Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
13.64Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.64Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
13.64Consensuslpa_onOrthosteric Ligandlpa1_on
13.64Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
13.64Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.64Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
13.33Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
13.33Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single6FJ3PTH6FJ3-PTH1-PTH
13.33Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.33Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.33Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.33Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.04Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.04Single6KQICP559406KQI-CB1-CP55940-Org27569
13.04Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.04Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.04Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.04Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.04Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.04Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
13.04Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
13.04Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
13.04Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
13.04Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.04Single8XYIVUF106618XYI-CXCR3-VUF10661
13.04Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
13.04Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.04Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.04Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.04Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.04Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
13.04Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
13.04Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
13.04Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
13.04Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
13.04Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.04Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
13.04Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
13.04Consensusorexin_onOrthosteric Ligandox2_on
13.04Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.90Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.90Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.90Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
12.90Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
12.90Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
12.90Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
12.90Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
12.90Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
12.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.50Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.50Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.50Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
12.50Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
12.50Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
12.50Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
12.50Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.50Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
12.50Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.50Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
12.50Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.50Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.50Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
12.50Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
12.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.50Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.50Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.50Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
12.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.50Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
12.50Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
12.50Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
12.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
12.50Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.50Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
12.50Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
12.50Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
12.50Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
12.50Consensussensory_onOrthosteric Ligandopsins_on
12.50Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single5GLHEndothelin-15GLH-ETB-Endothelin-1
12.12Single6IGKEndothelin-36IGK-ETB-Endothelin-3
12.12Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.12Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.12Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.00Single5EE7MK08935EE7-Glucagon-MK0893
12.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
12.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
12.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
12.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
12.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
12.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
12.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
12.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
11.76Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.76Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.76Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.76Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.76Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.76Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
11.76Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.76Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.76Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.76Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.76Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.76Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
11.76Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.76Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.76Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
11.76Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
11.76Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.76Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.76Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
11.54Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.54Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
11.54Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
11.54Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.54Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
11.54Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
11.54Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.54Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.54Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.54Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
11.54Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
11.54Consensuslpl_onOrthosteric Ligands1p_on lpa_on
11.54Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
11.54Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.54Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.43Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
11.11Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
11.11Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7UL2SR486927UL2-NTS1-SR48692-Na
11.11Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
11.11Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
11.11Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.11Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
11.11Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
11.11Single8K5BNiacin8K5B-HCA2-Niacin
11.11Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
11.11Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.11Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.11Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.11Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
11.11Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
11.11Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
11.11Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
11.11Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
11.11Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
11.11Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusneurotensin_offOrthosteric Ligandnts1_off
11.11Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.71Single3OE0CVX153OE0-CXCR4-CVX15
10.71Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
10.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
10.71Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
10.71Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
10.71Consensusangiotensin_onOrthosteric Ligandat1_on
10.71Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
10.71Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.71Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
10.71Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.53Single4K5YCP-3763954K5Y-CRF1-CP-376395
10.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
10.53Single5WS3EMPA5WS3-OX2-EMPA
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6AKYMaraviroc6AKY-CCR5-Maraviroc
10.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
10.53Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.53Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
10.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.53Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.53Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.53Single7XRRLemborexant7XRR-OX2-Lemborexant
10.53Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
10.53Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.53Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
10.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.53Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
10.53Single8IWESpermidine8IWE-TA9-Spermidine
10.53Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
10.53Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.53Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.53Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.53Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
10.53Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.53Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.34Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
10.34Single6JODAngiotensin II6JOD-AT2-Angiotensin II
10.34Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.34Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.34Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
10.34Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
10.34Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.34Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
10.34Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.34Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
10.34Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
10.34Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.34Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.34Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
10.34Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.34Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6KUXRS-799486KUX-α2a-RS-79948
10.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.00Single6V9SGTPL114036V9S-OX1-GTPL11403
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
10.00Single6ZINSR486926ZIN-NTS1-SR48692
10.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
10.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.00Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
10.00Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.00Single7UL3Famotidine7UL3-H2-Famotidine
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
10.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
10.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
10.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
10.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
10.00Single8IHKAcifran8IHK-HCA3-Acifran
10.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
10.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
10.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
10.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
10.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8K5CAcipimox8K5C-HCA2-Acipimox
10.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
10.00Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
10.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
10.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
10.00Consensushca_onOrthosteric Ligandhca2_on
10.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.68Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
9.68Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
9.68Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.68Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
9.68Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
9.68Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.68Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
9.68Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
9.68Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
9.68Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
9.68Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
9.68Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
9.52Single2Y01Dobutamine2Y01-β1-Dobutamine
9.52Single4QIMANTA XV4QIM-SMO-ANTA XV
9.52Single4QKX35V4QKX-β2-35V
9.52Single4Z9GCP-3763954Z9G-CRF1-CP-376395
9.52Single5TGZAM65385TGZ-CB1-AM6538
9.52Single6D27CAY104716D27-DP2-CAY10471
9.52Single6IIVDaltroban6IIV-TP-Daltroban
9.52Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
9.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.52Single7BU7BI1671077BU7-β1-BI167107
9.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.52Single7V3ZCP559407V3Z-CB1-CP55940
9.52Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
9.52Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.52Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
9.52Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.52Single8GTIBMK-C2058GTI-CRF1-BMK-C205
9.52Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
9.52Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.52Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
9.52Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.52Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
9.52Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.52Single8K5DGSK2560738K5D-HCA2-GSK256073
9.52Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
9.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.52Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
9.52Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
9.52Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
9.52Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
9.52Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensusblt_onOrthosteric Ligandblt1_on
9.52Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.52Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.52Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
9.52Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
9.52Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.52Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
9.52Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
9.52Consensushca_on_gpOrthosteric Ligandhca2_on_gp
9.52Consensusleukotriene_onOrthosteric Ligandblt_on
9.52Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.52Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.52Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.52Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
9.38Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.38Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.09Single2Y00Dobutamine2Y00-β1-Dobutamine
9.09Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.09Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
9.09Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.09Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.09Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.09Single8GTGBMK-I1528GTG-CRF1-BMK-I152
9.09Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
9.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
9.09Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
9.09Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
9.09Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.09Consensusblt_offOrthosteric Ligandblt1_off
9.09Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
8.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.82Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
8.70Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.70Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.70Single5TZRMK86665TZR-FFA1-MK8666
8.70Single5V56TC1145V56-SMO-TC114
8.70Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
8.70Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.70Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.70Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.70Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
8.70Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
8.70Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.70Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.70Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.70Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
8.70Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
8.70Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
8.70Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
8.70Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.70Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
8.70Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.70Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
8.70Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.70Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
8.70Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusneurotensin_onOrthosteric Ligandnts1_on
8.70Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
8.33Single5X33BIIL2605X33-BLT1-BIIL260
8.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.33Single6IIURamatroban6IIU-TP-Ramatroban
8.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
8.33Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
8.33Single7K15MKD0467K15-BLT1-MKD046-Na
8.33Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.33Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.33Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
8.33Single8GTMBMK-C2038GTM-CRF1-BMK-C203
8.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
8.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XWACXCL18XWA-CXCR2-CXCL1
8.33Single8XWMCXCL68XWM-CXCR2-CXCL6
8.33Single8XWSCXCL58XWS-CXCR2-CXCL5
8.33Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.33Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
8.33Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.33Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
8.33Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.00Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
8.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
8.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
8.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.00Single8XVUCXCL28XVU-CXCR2-CXCL2
8.00Single8XWFCXCL38XWF-CXCR2-CXCL3
8.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
8.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
8.00Consensuschemerin_onOrthosteric Ligandcml1_on
8.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
7.69Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.69Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
7.69Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.69Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
7.69Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
7.69Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.69Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
7.69Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.69Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
7.69Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
7.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
7.69Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.69Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
7.41Single4XT1Fractalkine4XT1-US28-Fractalkine
7.41Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
7.41Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7.41Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.41Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.41Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
7.41Single8XWNCXCL88XWN-CXCR2-CXCL8
7.41Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
7.41Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
7.41Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
7.41Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.41Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
7.41Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
7.14Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.14Single7SK5CXCL127SK5-ACKR3-CXCL12
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.14Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
7.14Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
7.14Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
6.90Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
6.90Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
6.90Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.90Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.67Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
6.67Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
6.67Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
6.67Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
6.67Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
6.67Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
6.67Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
6.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.67Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
6.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
6.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
6.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
6.45Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.45Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
6.45Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.45Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
6.45Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.45Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
6.45Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
6.45Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
6.25Single4XT3Fractalkine4XT3-US28-Fractalkine
6.25Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
6.25Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.25Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
6.25Single7SK3CXCL127SK3-ACKR3-CXCL12
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.25Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
6.25Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.25Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
6.25Single8PWNTheophylline8PWN-A2A-Theophylline
6.25Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
6.06Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
6.06Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
6.06Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single6TQ9SB-4081246TQ9-OX1-SB-408124
5.88Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off
5.56Single3OE6IT1t3OE6-CXCR4-IT1t
5.56Single4XNWMRS25004XNW-P2Y1-MRS2500
5.56Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.56Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.56Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
5.56Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.56Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.56Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.56Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.56Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
5.56Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.56Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.56Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
5.56Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
5.56Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
5.56Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
5.56Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.41Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
5.41Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
5.41Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
5.26Single3OE9IT1t3OE9-CXCR4-IT1t
5.26Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.26Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.26Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
5.26Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.26Single8HNNSCH5467388HNN-CXCR3-SCH546738
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.26Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
5.26Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.26Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.26Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.26Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.26Single9B9Y7DY9B9Y-CB1-7DY
5.00Single3ODUIT1t3ODU-CXCR4-IT1t
5.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single5U09Taranabant5U09-CB1-Taranabant
5.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.00Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
5.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
5.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
5.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
5.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Single9BA0A1AKN9BA0-CB1-A1AKN
5.00Consensusangiotensin_offOrthosteric Ligandat1_off
5.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
4.76Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
4.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
4.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.76Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.76Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Single8K2WAMG4878K2W-CXCR3-AMG487
4.76Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
4.76Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
4.76Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
4.55Single4YAYZD-71554YAY-AT1-ZD-7155
4.55Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
4.55Single6GPSMK08126GPS-CCR2-MK0812
4.55Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.55Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.55Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.55Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Single7YXAONO-54306087YXA-S1P5-ONO-5430608
4.55Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
4.55Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.55Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
4.55Single9B9ZA1AKO9B9Z-CB1-A1AKO
4.55Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.55Single9IYAONO-97105319IYA-GPR55-ONO-9710531
4.55Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.55Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
4.55Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
4.55Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.35Single4JKVTaladegib4JKV-SMO-Taladegib
4.35Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.35Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
4.35Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
4.35Single6D26Fevipiprant6D26-DP2-Fevipiprant
4.35Single6GPXMK08126GPX-CCR2-MK0812
4.35Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.35Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.35Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
4.35Consensusdp_offOrthosteric Liganddp2_off
4.35Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
4.35Consensusep_offOrthosteric Ligandep4_off
4.35Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.35Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.17Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
4.17Single9BJKNAM9BJK-μ-Naloxone-NAM
4.17Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
4.17Consensusrelaxin_onOrthosteric Ligandrxfp4_on
4.17Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
4.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
4.00Single6OS2TRV0266OS2-AT1-TRV026
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
4.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
3.85Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.85Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
3.85Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
3.85Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusprostanoid_offOrthosteric Ligandep_off dp_off
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.70Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.70Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.57Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
3.57Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.57Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
3.45Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.45Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
3.45Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.33Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.23Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.23Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
3.23Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
3.12Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
2.70Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2

PDB Summary
PDB 7E9G
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu2; mGlu2
Species Homo Sapiens
Ligand Eglumetad
Other Ligand(s) JNJ-40411813
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.5
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03495-2
Net Summary
Imin 1.62
Number of Linked Nodes 1975
Number of Links 3050
Number of Hubs 681
Number of Links mediated by Hubs 2310
Number of Communities 42
Number of Nodes involved in Communities 1020
Number of Links involved in Communities 1813
Path Summary
Number Of Nodes in MetaPath 597
Number Of Links MetaPath 596
Number of Shortest Paths 246069385
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 89
Minimum Path Strength 1.315
Average Path Strength 8.07062
Maximum Path Strength 25.2
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 128
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • glutamate receptor activity   • scaffold protein binding   • protein binding   • binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • channel regulator activity   • monoatomic ion channel activity   • ion channel regulator activity   • calcium channel regulator activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • inorganic molecular entity transmembrane transporter activity   • channel activity   • inorganic cation transmembrane transporter activity   • molecular function regulator activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transporter regulator activity   • transmembrane transporter activity   • group II metabotropic glutamate receptor activity   • G protein-coupled glutamate receptor activity   • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity   • regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion
Gene OntologyBiological Process• regulation of localization   • nitrogen compound transport   • regulation of cellular process   • transport   • regulation of glutamate secretion   • localization   • secretion by cell   • regulation of secretion by cell   • regulation of amino acid transport   • glutamate secretion   • regulation of biological process   • organic anion transport   • carboxylic acid transport   • secretion   • regulation of transport   • biological regulation   • export from cell   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • acidic amino acid transport   • regulation of organic acid transport   • dicarboxylic acid transport   • cellular process   • regulation of amine transport   • trans-synaptic signaling   • regulation of signaling   • modulation of chemical synaptic transmission   • signaling   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • monoamine transport   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • catecholamine transport   • signal release   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • regulation of response to stimulus   • response to chemical   • regulation of response to drug   • response to xenobiotic stimulus   • cellular response to stimulus   • positive regulation of cell communication   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • positive regulation of intracellular signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of signaling   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • cellular response to stress   • response to stress   • intracellular amino acid homeostasis   • cellular homeostasis   • intracellular glutamate homeostasis   • chemical homeostasis   • homeostatic process   • intracellular chemical homeostasis   • biosynthetic process   • metabolic process   • macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • cell surface receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • G protein-coupled receptor signaling pathway   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of synaptic transmission   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of biological quality   • regulation of synaptic plasticity   • long-term synaptic depression   • behavior   • adult behavior   • multicellular organismal process   • response to nicotine   • behavioral response to nicotine   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • response to oxygen-containing compound   • response to nitrogen compound   • response to cocaine   • response to alkaloid   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • glial cell projection   • cell projection   • plasma membrane bounded cell projection   • astrocyte projection   • presynapse   • presynaptic membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • neuron projection   • glutamatergic synapse   • axon   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Type 1 solute binding protein-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code40F
PDB ResiduesL:L:?901 M:M:?901
Environment DetailsOpen EMBL-EBI Page
Code40F
Name(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Synonyms
Identifier
FormulaC8 H11 N O4
Molecular Weight185.177
SMILES
PubChem213056
Formal Charge0
Total Atoms24
Total Chiral Atoms4
Total Bonds25
Total Aromatic Bonds0

CodeHZR
PDB ResiduesW:W:?902
Environment DetailsOpen EMBL-EBI Page
CodeHZR
NameJNJ-40411813
SynonymsJNJ-40411813
Identifier
FormulaC20 H25 Cl N2 O
Molecular Weight344.878
SMILES
PubChem25195461
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7E9G_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKNTIV 
KQMKITGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLAEDEE MNRMHASMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCSTDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7E9G_Chain_B
LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT DSRLLVSAS 
QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN YVACGGLDN 
ICSIYNLKT REGNVRVSR ELAGHTGYL SCCRFLDDN QIVTSSGDT 
TCALWDIET GQQTTTFTG HTGDVMSLS LAPDTRLFV SGACDASAK 
LWDVREGMC RQTFTGHES DINAICFFP NGNAFATGS DDATCRLFD 
LRADQELMT YSHDNIICG ITSVSFSKS GRLLLAGYD DFNCNVWDA 
LKADRAGVL AGHDNRVSC LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7E9G_Chain_G
KVSKAAADL MAYCEAHAK EDPLLTPVP ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLIT 
GVIGGSYSD VSIQVANLL RLFQIPQIS YASTSAKLS DKSRYDYFA 
RTVPPDFFQ AKAMAEILR FFNWTYVST VASEGDYGE TGIEAFELE 
ARARNICVA TSEKVGRAM SRAAFEGVV RALLQKPSA RVAVLFTRS 
EDARELLAA SQRLNASFT WVASDGWGA LESVVAGSE GAAEGAITI 
ELASYPISD FASYFQSLD PWNNSRNPW FREFWEQRF RCSFRQRDC 
AAHSLRAVP FEQESKIMF VVNAVYAMA HALHNMHRA LCPNTTRLC 
DAMRPVNGR RLYKDFVLN VKFDAPFRP ADTHNEVRF DRFGDGIGR 
YNIFTYLRA GSGRYRYQK VGYWAEGLT LDTSLIPWA SPSAGPLPA 
SRCSEPCLQ NEVKSVQPG EVCCWLCIP CQPYEYRLD EFTCADCGL 
GYWPNASLT GCFELPQEY IRWGDAWAV GPVTIACLG ALATLFVLG 
VFVRHNATP VVKAAGREL CYILLGGVF LCYCMTFIF IAKPSTAVC 
TLRRLGLGT AFSVCYSAL LTKTNRIAR IFGGAREGA QRPRFISPA 
SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER REVVTLRCN 
HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE AKFIGFTMY 
TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS VVLGCLFAP 
KLHI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_Chain_S
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLTA 
ITGVIGGSY SDVSIQVAN LLRLFQIPQ ISYASTSAK LSDKSRYDY 
FARTVPPDF FQAKAMAEI LRFFNWTYV STVASEGDY GETGIEAFE 
LEARARNIC VATSEKVGR AMSRAAFEG VVRALLQKP SARVAVLFT 
RSEDARELL AASQRLNAS FTWVASDGW GALESVVAG SEGAAEGAI 
TIELASYPI SDFASYFQS LDPWNNSRN PWFREFWEQ RFRCSFRQR 
DCAAHSLRA VPFEQESKI MFVVNAVYA MAHALHNMH RALCPNTTR 
LCDAMRPVN GRRLYKDFV LNVKFDAPF RPADTHNEV RFDRFGDGI 
GRYNIFTYL RAGSGRYRY QKVGYWAEG LTLDTSLIP WASPSAGPL 
PASRCSEPC LQNEVKSVQ PGEVCCWLC IPCQPYEYR LDEFTCADC 
GLGYWPNAS LTGCFELPQ EYIRWGDAW AVGPVTIAC LGALATLFV 
LGVFVRHNA TPVVKAAGR ELCYILLGG VFLCYCMTF IFIAKPSTA 
VCTLRRLGL GTAFSVCYS ALLTKTNRI SPASQVAIC LALISGQLL 
IVVAWLVVE APGTGKETA PERREVVTL RCNHRDASM LGSLAYNVL 
LIALCTLYA FKTRKCPEN FNEAKFIGF TMYTTCIIW LAFLPIFYV 
TSSDYRVQT TTMCVSVSL SGSVVLGCL FAPKLHII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WGDCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensWAG/WA6--4.452024-11-27To be published
8WGCCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensLY379268--5.952024-11-27To be published
8WG9CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiens(2S)-2-amino-4-phosphonobutanoic acid--4.462024-11-27To be published
8WGBCAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9RGi3/β1/γ23.72024-10-30doi.org/10.1038/s41467-024-54744-7
8WGB (No Gprot) CAminoacidMetabotropic GlutamatemGlu4; mGlu2Homo sapiensGlutammateW9R3.72024-10-30doi.org/10.1038/s41467-024-54744-7
8JD2CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateNAM563-3.32023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCUCAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/β1/γ23.32023-06-2110.1038/s41422-023-00830-2
8JD3 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEF3.32023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/β1/γ23.62023-06-2110.1038/s41422-023-00830-2
8JD5 (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEF3.62023-06-2110.1038/s41422-023-00830-2
7MTRCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTQCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/β1/γ23.22021-07-0710.1038/s41586-021-03680-3
7MTS (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensGlutamateADX551643.22021-07-0710.1038/s41586-021-03680-3
7EPFCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7EPECAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens-NAM563-2.52021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPACAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPDCAminoacidMetabotropic GlutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w
7E9GCAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/β1/γ23.52021-06-2310.1038/s41586-021-03495-2
7E9G (No Gprot) CAminoacidMetabotropic GlutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-404118133.52021-06-2310.1038/s41586-021-03495-2




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