Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L26 4.0075415
2R:R:G35 2.732519
3R:R:G36 2.166518
4R:R:L37 2.6125416
5R:R:F38 9.548518
6R:R:P39 3.94286715
7R:R:V40 5.788516
8R:R:H41 6.81718
9R:R:K43 3.714513
10R:R:G44 2.325414
11R:R:V53 4.614513
12R:R:E55 2.5525415
13R:R:H56 9.648513
14R:R:R57 10.0783614
15R:R:I59 4.9875416
16R:R:Q60 5.335417
17R:R:R61 6.2741014
18R:R:L62 5.44515
19R:R:E63 5.17125818
20R:R:A64 3.05417
21R:R:M65 4.458519
22R:R:F67 9.132517
23R:R:R71 8.722517
24R:R:I72 7.395419
25R:R:L78 5.86667617
26R:R:L79 3.716519
27R:R:V82 4.775415
28R:R:L84 3.50167619
29R:R:A86 2.86417
30R:R:H87 4.85614
31R:R:I88 6.884517
32R:R:L89 7.175415
33R:R:D90 8.71419
34R:R:S91 2.8475416
35R:R:C92 8.905418
36R:R:K94 4.475413
37R:R:D95 8.5225414
38R:R:H97 11.6425413
39R:R:L99 6.055615
40R:R:Q101 6.986515
41R:R:A102 2.3975416
42R:R:F105 5.87167616
43R:R:I136 3.648516
44R:R:G138 3.225417
45R:R:V139 3.152517
46R:R:I140 4.106517
47R:R:G141 2.712518
48R:R:G142 2.38415
49R:R:S143 4.858514
50R:R:Y144 8.29333613
51R:R:D146 7.644515
52R:R:V147 2.82571714
53R:R:S148 3.94167617
54R:R:I149 7.7275415
55R:R:V151 4.0925415
56R:R:N153 8.5225415
57R:R:L155 4.348516
58R:R:R156 6.244515
59R:R:L157 4.3875415
60R:R:F158 6.354516
61R:R:P161 2.86167619
62R:R:Q162 6.1725418
63R:R:I163 4.18571717
64R:R:S164 3.9419
65R:R:Y165 7.40714718
66R:R:A166 3.796515
67R:R:T168 5.008517
68R:R:S169 5.4625407
69R:R:K171 6.08513
70R:R:L172 7.00833617
71R:R:S173 4.34418
72R:R:R177 7.61333615
73R:R:Y178 9.496516
74R:R:Y180 9.92416
75R:R:F181 6.57429719
76R:R:A182 2.356516
77R:R:R183 7.75667619
78R:R:T184 5.1375409
79R:R:V185 5.058517
80R:R:P186 3.49714718
81R:R:P187 6.37667617
82R:R:D188 4.754518
83R:R:F190 7.12833615
84R:R:Q191 7.535618
85R:R:K193 7.385413
86R:R:M195 5.74417
87R:R:E197 8.442516
88R:R:I198 4.3075418
89R:R:L199 4.255616
90R:R:R200 3.4075404
91R:R:F201 4.995415
92R:R:F202 5.57818
93R:R:W204 7.696519
94R:R:Y206 6.1425159
95R:R:V207 3.715418
96R:R:S208 3.215158
97R:R:T209 3.352516
98R:R:V210 4.138515
99R:R:S212 4.4675416
100R:R:D215 4.9775415
101R:R:Y216 7.70375817
102R:R:I221 4.4825405
103R:R:F224 4.58517
104R:R:E227 4.7075415
105R:R:R231 4.896514
106R:R:I233 2.838516
107R:R:A236 3.0125158
108R:R:V241 2.97571716
109R:R:R243 11.0925412
110R:R:M245 4.925413
111R:R:F250 7.042513
112R:R:E251 5.3575412
113R:R:V254 2.816515
114R:R:K260 5.4465154
115R:R:A263 1.974157
116R:R:V265 4.35518
117R:R:V267 6.82416
118R:R:L268 3.41833615
119R:R:F269 6.17167617
120R:R:T270 3.07614
121R:R:R271 8.41667915
122R:R:E273 5.494511
123R:R:D274 4.9614
124R:R:L278 4.156515
125R:R:L279 5.9925415
126R:R:S282 3.2075414
127R:R:R284 9.115413
128R:R:A287 2.7275414
129R:R:W291 6.11286717
130R:R:V292 4.6625417
131R:R:D295 5.37571718
132R:R:W297 6.98625816
133R:R:L300 4.355615
134R:R:V303 5.9325414
135R:R:V304 5.445414
136R:R:E308 7.12414
137R:R:I317 3.302516
138R:R:E318 5.76667616
139R:R:L319 6.22614
140R:R:Y322 6.278513
141R:R:I324 4.366516
142R:R:D326 5.14414
143R:R:F327 6.29778918
144R:R:Y330 6.624518
145R:R:F331 4.81125816
146R:R:L334 6.804515
147R:R:P336 11.618516
148R:R:N339 5.6775414
149R:R:R341 5.446504
150R:R:N342 6.29167617
151R:R:W344 6.24571714
152R:R:F345 5.26714714
153R:R:F348 5.54833616
154R:R:W349 7.73625818
155R:R:F353 10.696517
156R:R:F357 9.0725413
157R:R:C362 4.745419
158R:R:L367 4.0125416
159R:R:F372 7.63167615
160R:R:Q374 5.03833615
161R:R:K377 5.01143713
162R:R:I378 5.302517
163R:R:M379 7.495408
164R:R:F380 8.13516
165R:R:V381 4.0125417
166R:R:V382 2.614518
167R:R:N383 5.2025408
168R:R:Y386 8.05571716
169R:R:A387 2.22167618
170R:R:M388 4.2075416
171R:R:A389 3.19419
172R:R:M395 3.8225415
173R:R:C400 3.604513
174R:R:L406 5.1675412
175R:R:M410 3.96412
176R:R:L418 3.265617
177R:R:Y419 3.69615
178R:R:F422 5.68375814
179R:R:V426 2.4875417
180R:R:F428 8.77833618
181R:R:A430 2.3425414
182R:R:P431 7.28833617
183R:R:F432 8.42667614
184R:R:R433 4.558513
185R:R:V441 5.566516
186R:R:F443 4.99429718
187R:R:F446 4.5575417
188R:R:D448 6.18571717
189R:R:Y453 7.33571718
190R:R:I455 4.56418
191R:R:F456 4.522515
192R:R:Y458 8.7825415
193R:R:L459 4.56754306
194R:R:Y468 5.4614
195R:R:V471 3.93417
196R:R:W474 7.63167616
197R:R:L478 6.0225416
198R:R:I485 6.8325417
199R:R:W487 5.2425817
200R:R:A488 4.13411
201R:R:K510 5.021676107
202R:R:W520 4.70254187
203R:R:C522 3.334189
204R:R:I523 5.57754104
205R:R:Y528 7.638336108
206R:R:E529 6.885108
207R:R:C537 4.47254109
208R:R:D539 6.37754103
209R:R:E559 9.514566
210R:R:T582 4.365477
211R:R:V585 3.215476
212R:R:V588 4.35476
213R:R:F589 4.4525479
214R:R:H592 3.8825474
215R:R:N593 4.8375475
216R:R:T595 4.2275479
217R:R:V598 3.9725479
218R:R:L605 5.75408
219R:R:Y607 6.068578
220R:R:L609 4.648508
221R:R:L610 3.612579
222R:R:G612 2.365408
223R:R:V613 3.03167678
224R:R:Y617 4.15143778
225R:R:M619 4.234567
226R:R:T620 5.3175477
227R:R:P627 4.83569
228R:R:R635 3.694568
229R:R:R636 10.3854348
230R:R:L639 3.146568
231R:R:T641 3.15406
232R:R:F643 8.028568
233R:R:C646 2.165406
234R:R:Y647 9.25667666
235R:R:T654 4.14754219
236R:R:R656 7.8925128
237R:R:R659 5.6445127
238R:R:I660 4.6645129
239R:R:E666 3.6775457
240R:R:G667 3.195455
241R:R:P676 3.264126
242R:R:C683 2.5275407
243R:R:Q690 6.235229
244R:R:P703 4.81409
245R:R:K707 6.22402
246R:R:E708 4.255467
247R:R:P711 3.058565
248R:R:V717 4.574568
249R:R:T718 8.5875466
250R:R:Y734 6.0725228
251R:R:C742 2.0454219
252R:R:Y745 3.545407
253R:R:F756 5.9025129
254R:R:M766 4.4945219
255R:R:T769 3.645408
256R:R:W773 8.82167669
257R:R:V782 3.7825238
258R:R:R788 7.55465
259R:R:V789 2.24335
260R:R:Q790 8.4125407
261R:R:S799 3.3575478
262R:R:L806 4.36678
263R:R:K813 4.8975479
264S:S:L26 5.28615
265S:S:L28 3.8625414
266S:S:G30 3.675419
267S:S:L32 3.56415
268S:S:L34 5.07286717
269S:S:G35 2.036519
270S:S:G36 2.78518
271S:S:L37 3.59333616
272S:S:F38 5.77429718
273S:S:P39 3.75667615
274S:S:V40 5.675416
275S:S:H41 5.29143718
276S:S:K43 5.605413
277S:S:V53 4.63413
278S:S:R57 8.89333614
279S:S:Q60 10.1075417
280S:S:R61 6.414551114
281S:S:L62 3.74667615
282S:S:E63 6.05571718
283S:S:M65 4.66375819
284S:S:L66 4.92667615
285S:S:F67 8.248517
286S:S:L69 3.676516
287S:S:R71 7.552517
288S:S:I72 5.37419
289S:S:L78 6.474517
290S:S:V82 5.1625415
291S:S:R83 6.83417
292S:S:A86 2.624517
293S:S:H87 5.374514
294S:S:I88 4.81429717
295S:S:L89 9.445415
296S:S:D90 4.858519
297S:S:S91 4.435416
298S:S:C92 5.955418
299S:S:T96 5.92412
300S:S:H97 5.68167613
301S:S:A98 2.095416
302S:S:L99 6.074515
303S:S:Q101 5.99515
304S:S:L103 5.835415
305S:S:F105 7.424516
306S:S:I140 4.35333617
307S:S:G141 2.6475418
308S:S:G142 2.735415
309S:S:S143 6.586514
310S:S:Y144 10.26513
311S:S:S145 3.955418
312S:S:D146 5.505415
313S:S:V147 3.83514
314S:S:S148 3.31833617
315S:S:I149 5.9775405
316S:S:V151 3.8225415
317S:S:N153 4.9175415
318S:S:R156 5.81615
319S:S:L157 6.176515
320S:S:F158 6.99333616
321S:S:I160 5.4825416
322S:S:P161 4.172519
323S:S:Q162 8.175408
324S:S:I163 4.902517
325S:S:Y165 7.95333618
326S:S:A166 3.842515
327S:S:S167 4.264518
328S:S:T168 4.72517
329S:S:L172 6.48517
330S:S:Y178 7.45506
331S:S:Y180 8.16416
332S:S:F181 8.94571719
333S:S:A182 2.9525416
334S:S:R183 8.13667619
335S:S:T184 2.81619
336S:S:V185 4.596517
337S:S:P186 4.232518
338S:S:P187 5.29714717
339S:S:D188 5.17518
340S:S:F189 5.98413
341S:S:F190 5.21515
342S:S:Q191 9.134518
343S:S:K193 7.675413
344S:S:M195 4.0875417
345S:S:E197 6.156516
346S:S:L199 3.64616
347S:S:R200 3.998514
348S:S:F201 4.3125415
349S:S:F202 5.9925818
350S:S:W204 6.08857719
351S:S:Y206 6.085619
352S:S:V207 3.775418
353S:S:S208 3.1575418
354S:S:T209 3.946516
355S:S:V210 1.91415
356S:S:S212 4.0675416
357S:S:Y216 9.385617
358S:S:T219 3.428514
359S:S:I221 4.485405
360S:S:F224 4.64833617
361S:S:R231 5.17143714
362S:S:I233 3.0925416
363S:S:A236 3.28418
364S:S:E239 3.54405
365S:S:V241 4.01143716
366S:S:R243 6.382512
367S:S:M245 7.0225413
368S:S:F250 8.808513
369S:S:E251 6.815412
370S:S:V254 2.494515
371S:S:L257 3.17407
372S:S:K260 3.33414
373S:S:A263 2.3025417
374S:S:V265 4.678518
375S:S:V267 4.92833616
376S:S:L268 3.856515
377S:S:F269 4.78667617
378S:S:T270 3.084514
379S:S:R271 7.70375815
380S:S:D274 5.34614
381S:S:L279 4.962515
382S:S:S282 2.805414
383S:S:R284 8.69413
384S:S:A287 2.3325414
385S:S:F289 6.2775416
386S:S:W291 7.10875817
387S:S:V292 3.986517
388S:S:D295 5.69833618
389S:S:W297 5.643641116
390S:S:L300 4.9075415
391S:S:V303 3.45167614
392S:S:V304 5.266514
393S:S:S307 2.6875413
394S:S:A310 2.3875413
395S:S:A311 2.95416
396S:S:E312 4.115405
397S:S:I315 4.9125415
398S:S:T316 4.8417
399S:S:I317 5.5075416
400S:S:E318 5.234516
401S:S:L319 5.4225414
402S:S:Y322 7.5125413
403S:S:I324 4.0525416
404S:S:D326 3.6475414
405S:S:F327 6.03667918
406S:S:Y330 6.55618
407S:S:F331 7.54667616
408S:S:P336 8.618516
409S:S:W337 5.28667613
410S:S:N339 5.468514
411S:S:R341 7.298514
412S:S:N342 6.244517
413S:S:P343 8.3625412
414S:S:W344 7.68143714
415S:S:F345 7.33429714
416S:S:F348 7.878516
417S:S:W349 7.8625818
418S:S:R352 5.975413
419S:S:F353 11.284517
420S:S:C355 5.1325418
421S:S:F357 7.23571713
422S:S:F372 7.665615
423S:S:Q374 7.124515
424S:S:E375 8.145415
425S:S:K377 4.82667613
426S:S:I378 6.255617
427S:S:M379 8.36418
428S:S:F380 6.14833616
429S:S:V381 5.3325417
430S:S:V382 4.036518
431S:S:N383 6.66418
432S:S:V385 3.834519
433S:S:Y386 5.885816
434S:S:A387 2.326518
435S:S:M395 3.632515
436S:S:C400 3.8875413
437S:S:L406 4.915412
438S:S:M410 4.506512
439S:S:N414 5.57414
440S:S:L418 4.762517
441S:S:Y419 4.97857715
442S:S:F422 5.44375814
443S:S:V426 4.3575417
444S:S:F428 8.982518
445S:S:A430 2.74514
446S:S:P431 4.36333617
447S:S:F432 4.99714714
448S:S:R433 4.606513
449S:S:V441 5.212516
450S:S:F443 5.52667618
451S:S:D444 3.1725418
452S:S:F446 6.155417
453S:S:G447 2.08417
454S:S:D448 6.1875817
455S:S:R452 4.4475404
456S:S:Y453 6.15429718
457S:S:I455 4.0575418
458S:S:F456 6.414515
459S:S:T457 4.328518
460S:S:Y458 9.30667615
461S:S:L459 4.272516
462S:S:Y468 6.90143714
463S:S:V471 4.655617
464S:S:W474 7.365616
465S:S:L478 4.15333616
466S:S:L480 4.23516
467S:S:I485 5.86143717
468S:S:W487 5.84875817
469S:S:A488 3.36511
470S:S:K510 6.664137
471S:S:S511 5.4575405
472S:S:Q513 5.86254195
473S:S:P514 5.32754195
474S:S:E516 5.556676194
475S:S:C518 4.11254199
476S:S:Y528 6.753336138
477S:S:E529 3.8954138
478S:S:C540 4.92254389
479S:S:T582 4.62254407
480S:S:L586 2.0775405
481S:S:F589 3.7365259
482S:S:L605 4.0354118
483S:S:G612 2.3325408
484S:S:Y617 4.9856408
485S:S:M619 3.8225407
486S:S:P627 4.2554399
487S:S:C632 4.8225499
488S:S:R635 7.405408
489S:S:R636 5.5575898
490S:S:F643 6.2525148
491S:S:C646 2.165406
492S:S:Y647 9.5545146
493S:S:S648 3.97754419
494S:S:L651 4.23754269
495S:S:K653 7.716119
496S:S:I657 4.5454119
497S:S:C683 3.032507
498S:S:W697 5.7697
499S:S:G704 2.752594
500S:S:T705 4.8125494
501S:S:C721 6.8375499
502S:S:R724 8.72333698
503S:S:L732 2.7185148
504S:S:Y745 2.63754267
505S:S:E758 10.074119
506S:S:I762 5.2585119
507S:S:M766 4.876676119
508S:S:W773 6.433336149
509S:S:F776 6.315149
510S:S:I779 4.15754237
511S:S:T783 2.26254237
512S:S:Y787 4.708505
513S:S:Q790 6.2475407
514S:S:V805 2.4475407
515S:S:F810 4.1854259
516S:S:K813 4.124259
517A:A:G27 2.614205
518A:A:V34 4.1375455
519A:A:L36 3.90667657
520A:A:L38 3.948558
521A:A:L39 2.686529
522A:A:T48 2.7459
523A:A:M53 6.9085428
524A:A:H188 7.724163
525A:A:F191 11.026555
526A:A:F196 6.86333657
527A:A:K197 8.9485166
528A:A:M198 2.73457
529A:A:F199 8.2154165
530A:A:D200 4.215459
531A:A:V201 5.01429
532A:A:Q204 5.274529
533A:A:S206 4.8375428
534A:A:E207 8.07429
535A:A:R208 6.28429
536A:A:K210 6.16333629
537A:A:W211 6.35143729
538A:A:H213 8.95438
539A:A:T219 2.822557
540A:A:A220 2558
541A:A:I222 5.08557
542A:A:F223 4.315629
543A:A:C224 3.11429757
544A:A:L227 8.934177
545A:A:Y230 5.64714728
546A:A:L234 3.555408
547A:A:R242 4.22409
548A:A:M247 4.5625426
549A:A:F250 4.74143729
550A:A:W258 11.148535
551A:A:I264 5.6225426
552A:A:I265 3.24333658
553A:A:L266 3.992529
554A:A:F267 4.154559
555A:A:N269 4.3125459
556A:A:K271 4.80254175
557A:A:F274 7.37409
558A:A:I278 2.8075426
559A:A:L283 5.1725427
560A:A:C286 5.075426
561A:A:Y287 4.56627
562A:A:Y290 6.9925427
563A:A:Y296 6.693336174
564A:A:E298 4.375424
565A:A:F307 3.39667628
566A:A:E308 6.45423
567A:A:L310 4.045404
568A:A:R313 9.99254444
569A:A:E318 6.7575454
570A:A:Y320 5.845657
571A:A:T321 8.255405
572A:A:F323 5.3756174
573A:A:F336 5.27558
574A:A:V342 4.265457
575A:A:L348 4.445129
576A:A:C351 4.6054124
577B:B:L30 10.894285
578B:B:I33 6.1854283
579B:B:T34 4.51445
580B:B:R48 4.5825437
581B:B:R49 4.38437
582B:B:L51 9.06439
583B:B:H54 8.48833639
584B:B:K57 11.1875439
585B:B:I58 5.4325439
586B:B:Y59 12.875438
587B:B:M61 4.71436
588B:B:W63 5.46875837
589B:B:R68 11.8654275
590B:B:L70 4.732535
591B:B:V71 4.65488
592B:B:D76 3.976676209
593B:B:K78 5.026208
594B:B:L79 3.368587
595B:B:I80 8.1875438
596B:B:I81 4.18587
597B:B:W82 9.13667639
598B:B:D83 9.01754278
599B:B:T86 5.984276
600B:B:N88 5.014277
601B:B:K89 8.00833639
602B:B:H91 8.3975485
603B:B:I93 3.88487
604B:B:L95 4.7125488
605B:B:W99 9.5425409
606B:B:V100 2.7975489
607B:B:Y105 3.68714786
608B:B:Y111 7.015624
609B:B:A113 2.598529
610B:B:C114 2.29488
611B:B:G115 2.3275429
612B:B:N119 3.3275429
613B:B:I120 4.6625406
614B:B:C121 3.315628
615B:B:I123 3.22714726
616B:B:Y124 4.96786
617B:B:L126 4.865485
618B:B:V133 5.724584
619B:B:H142 7.90429729
620B:B:G144 3.04408
621B:B:Y145 4.97625828
622B:B:L146 3.754527
623B:B:C148 3.3925426
624B:B:C149 2.75143728
625B:B:R150 6.1225426
626B:B:F151 6.25167629
627B:B:L152 4.8975423
628B:B:Q156 7425
629B:B:I157 7.19427
630B:B:T159 4.402529
631B:B:S160 3.53526
632B:B:S161 5.13667629
633B:B:G162 2.905429
634B:B:D163 7.125629
635B:B:C166 3.15667628
636B:B:W169 11.294528
637B:B:Q176 8.4925424
638B:B:F180 8.592527
639B:B:H183 7.575629
640B:B:D186 4.98529
641B:B:V187 3.144529
642B:B:M188 5.6325428
643B:B:L190 3.845825
644B:B:L192 4.5525
645B:B:F199 5.96286729
646B:B:V200 4.47667626
647B:B:S201 2.664529
648B:B:G202 2.3406
649B:B:C204 5.5375427
650B:B:D205 6.146529
651B:B:A208 1.7375426
652B:B:K209 13.996526
653B:B:L210 4.73405
654B:B:W211 9.73429728
655B:B:H225 12.5275429
656B:B:S227 4.4925426
657B:B:D228 3.465429
658B:B:I232 4.43833628
659B:B:F234 3.88333625
660B:B:F235 7.61746
661B:B:P236 4.585447
662B:B:N237 8.38445
663B:B:A240 2.9875446
664B:B:F241 8.13626
665B:B:A242 2.166544
666B:B:T243 5.05828
667B:B:S245 5.28529
668B:B:D246 4.925429
669B:B:D247 6.535429
670B:B:C250 3.4225448
671B:B:R251 16.6428
672B:B:L252 2.67647
673B:B:D254 5.722549
674B:B:L261 4.556545
675B:B:Y264 5.63833645
676B:B:I269 5.71544
677B:B:I273 4.624546
678B:B:V276 4.445446
679B:B:F278 5.805647
680B:B:S279 5.33439
681B:B:S281 3.0275409
682B:B:R283 9.96754459
683B:B:L284 8.57435
684B:B:L285 3.51571746
685B:B:L286 6.4925437
686B:B:A287 2.53646
687B:B:G288 2.7825447
688B:B:Y289 5.126547
689B:B:D291 5.2675448
690B:B:C294 3.734545
691B:B:W297 7.28648
692B:B:L300 5.816546
693B:B:R304 8.8525445
694B:B:L308 4.39407
695B:B:H311 9.116549
696B:B:R314 10.9586738
697B:B:V315 2.946547
698B:B:C317 3.4437
699B:B:L318 3.9375446
700B:B:V320 3.538537
701B:B:T321 5.394537
702B:B:D323 4.92537
703B:B:G324 1.795839
704B:B:A326 2.8375437
705B:B:V327 5.72436
706B:B:A328 2.2525435
707B:B:T329 6.075448
708B:B:G330 2.51535
709B:B:W332 11.1714739
710B:B:D333 7.71449
711B:B:L336 4.866537
712B:B:K337 10.3446
713B:B:I338 2.81333635
714B:B:W339 8.09549
715G:G:V30 5.15408
716G:G:L37 3.972547
717G:G:Y40 12.6125446
718G:G:C41 2.246507
719G:G:H44 8.21406
720G:G:D48 6.25333639
721G:G:L50 5.90429739
722G:G:L51 4.3725406
723G:G:N59 5.33439
724G:G:F61 5.02625838
725L:L:?901 7.348331210
726W:W:?902 9.127271160
727M:M:?901 9.0071010
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E100 R:R:K23 26.22435.4NoNo043
2R:R:H41 R:R:W344 37.23043.17YesYes184
3R:R:K24 R:R:W344 29.29369.28NoYes044
4R:R:C92 R:R:D90 17.62726.22YesYes189
5R:R:H97 R:R:Q101 52.698712.36YesYes135
6R:R:L89 R:R:Q101 10011.98YesYes155
7R:R:L89 R:R:V25 1002.98YesNo154
8R:R:H87 R:R:T27 58.62095.48YesNo144
9R:R:I88 R:R:L26 19.7795.71YesYes175
10R:R:I88 R:R:L62 16.12148.56YesYes175
11R:R:L37 R:R:Q101 1002.66YesYes165
12R:R:G141 R:R:L37 46.92861.71YesYes186
13R:R:G141 R:R:G36 1002.11YesYes188
14R:R:G36 R:R:I88 43.30561.76YesYes187
15R:R:F105 R:R:L89 57.27297.31YesYes165
16R:R:F105 R:R:G36 93.75513.01YesYes168
17R:R:A86 R:R:M65 15.68751.61YesYes179
18R:R:F38 R:R:M65 1007.46YesYes189
19R:R:P39 R:R:S91 1003.56YesYes156
20R:R:L37 R:R:S91 1004.5YesYes166
21R:R:G141 R:R:Y165 1005.79YesYes188
22R:R:L79 R:R:V82 50.86855.96YesYes195
23R:R:L79 R:R:L84 90.05385.54YesYes199
24R:R:L69 R:R:L84 1004.15NoYes169
25R:R:L69 R:R:M65 1002.83NoYes169
26R:R:M395 R:R:M410 1004.33YesYes152
27R:R:L418 R:R:M395 1004.24YesYes175
28R:R:L418 R:R:P161 1004.93YesYes179
29R:R:I160 R:R:P161 17.21891.69NoYes069
30R:R:I140 R:R:Y165 1002.42YesYes178
31R:R:I140 R:R:M388 1005.83YesYes176
32R:R:G138 R:R:M388 58.5833.49YesYes176
33R:R:G138 R:R:T137 35.16793.64YesNo074
34R:R:L32 R:R:T137 11.72748.84NoNo054
35R:R:L392 R:R:L418 15.97894.15NoYes087
36R:R:G138 R:R:L34 11.90311.71YesNo077
37R:R:G35 R:R:H87 85.93131.59YesYes194
38R:R:G141 R:R:V139 1001.84YesYes187
39R:R:F105 R:R:V139 78.13983.93YesYes167
40R:R:A98 R:R:L37 1001.58NoYes166
41R:R:R61 R:R:Y165 1003.09YesYes148
42R:R:N54 R:R:P39 1003.26NoYes145
43R:R:G58 R:R:P39 37.10932.03NoYes165
44R:R:D49 R:R:H97 70.26468.82NoYes013
45R:R:D49 R:R:K94 87.83525.53NoYes013
46R:R:K43 R:R:K94 1002.87YesYes133
47R:R:K43 R:R:R271 1002.48YesYes135
48R:R:R271 R:R:S93 1002.64YesNo151
49R:R:P39 R:R:S93 1001.78YesNo151
50R:R:P39 R:R:S143 50.79957.13YesYes154
51R:R:S143 R:R:Y165 1006.36YesYes148
52R:R:R271 R:R:Y144 10022.64YesYes153
53R:R:E273 R:R:K43 99.68624.05YesYes113
54R:R:E273 R:R:Y144 1003.37YesYes113
55R:R:P39 R:R:Y144 1006.95YesYes153
56R:R:S91 R:R:V147 1001.62YesYes164
57R:R:V147 R:R:Y144 1003.79YesYes143
58R:R:A98 R:R:V147 1005.09NoYes164
59R:R:C50 R:R:C92 35.1387.28NoYes198
60R:R:N54 R:R:Q42 1007.92NoNo043
61R:R:P52 R:R:Q42 10015.79NoNo033
62R:R:C50 R:R:G44 1001.96NoYes194
63R:R:G44 R:R:G45 35.1642.11YesNo046
64R:R:G45 R:R:P46 17.5824.06NoNo064
65R:R:A47 R:R:E48 37.10933.02NoNo031
66R:R:E48 R:R:G51 74.21874.91NoNo014
67R:R:G51 R:R:P52 1004.06NoNo043
68R:R:E55 R:R:Q351 10.76892.55YesNo153
69R:R:E55 R:R:S302 61.58812.87YesNo151
70R:R:H56 R:R:L300 19.64965.14YesYes135
71R:R:A166 R:R:Y165 1002.67YesYes158
72R:R:I378 R:R:R61 1002.51YesYes174
73R:R:V381 R:R:V382 1001.6YesYes178
74R:R:I140 R:R:V385 11.77764.61YesNo079
75R:R:F327 R:R:F67 24.51593.22YesYes187
76R:R:F432 R:R:I324 66.52945.02YesYes146
77R:R:I324 R:R:I378 70.40942.94YesYes167
78R:R:P431 R:R:V382 58.69651.77YesYes178
79R:R:A68 R:R:V382 50.84143.39NoYes088
80R:R:A68 R:R:Y386 46.95662.67NoYes086
81R:R:P431 R:R:Y386 10023.64YesYes176
82R:R:I72 R:R:Y386 17.612813.3YesYes196
83R:R:L78 R:R:Y386 1002.34YesYes176
84R:R:D75 R:R:L78 52.92155.43NoYes177
85R:R:D75 R:R:P76 17.64056.44NoNo173
86R:R:D75 R:R:H77 17.64052.52NoNo173
87R:R:F428 R:R:H390 21.583627.15YesNo086
88R:R:I140 R:R:I163 11.75994.42YesYes177
89R:R:F428 R:R:P431 19.55852.89YesYes187
90R:R:H393 R:R:L78 1002.57NoYes077
91R:R:H393 R:R:L79 23.56653.86NoYes079
92R:R:L79 R:R:P80 11.79721.64YesNo198
93R:R:H396 R:R:V82 27.36242.77NoYes035
94R:R:C400 R:R:H396 23.47357.37YesNo033
95R:R:C400 R:R:M410 1001.62YesYes132
96R:R:E100 R:R:T96 13.14332.82NoNo042
97R:R:D146 R:R:V147 1002.92YesYes154
98R:R:D146 R:R:R271 1003.57YesYes155
99R:R:D95 R:R:V147 20.51362.92YesYes144
100R:R:E100 S:S:L157 19.7922.65NoYes045
101R:R:L99 S:S:L157 11.962112.46YesYes155
102R:R:D95 S:S:R177 22.37774.76YesNo045
103R:R:T96 S:S:R156 16.60059.06NoYes025
104S:S:L157 S:S:R156 23.55893.64YesYes155
105R:R:A102 R:R:L99 46.06871.58YesYes165
106S:S:N153 S:S:R156 20.95754.82YesYes155
107R:R:L99 S:S:N153 61.40592.75YesYes155
108R:R:V147 R:R:V151 69.13731.6YesYes145
109R:R:L155 R:R:V139 14.61634.47YesYes167
110R:R:L103 S:S:L157 11.74659.69NoYes155
111R:R:L103 R:R:R107 13.06713.64NoNo057
112R:R:L418 R:R:V413 15.9632.98YesNo073
113R:R:G142 R:R:S164 34.49541.86YesYes159
114R:R:S145 R:R:S169 40.50796.52NoYes087
115R:R:L172 R:R:S148 17.61093YesYes177
116R:R:L172 R:R:S169 70.55526.01YesYes077
117L:L:?901 R:R:Y216 10024.68YesYes107
118R:R:Q162 R:R:V151 35.81278.6YesYes185
119R:R:F181 R:R:S164 42.62633.96YesYes199
120R:R:I149 R:R:Y178 26.432510.88YesYes156
121R:R:A152 R:R:F181 1004.16NoYes079
122R:R:A152 R:R:Y178 1004NoYes076
123S:S:N153 S:S:Y178 84.95548.14YesYes056
124S:S:I149 S:S:Q150 75.65652.74YesNo055
125R:R:N153 S:S:Q150 32.663115.85YesNo155
126R:R:R156 S:S:L99 31.30196.07YesYes155
127R:R:D179 R:R:R156 44.25047.15NoYes175
128R:R:R156 R:R:Y180 1004.12YesYes156
129R:R:G415 R:R:P161 13.13152.03NoYes169
130R:R:G415 R:R:N414 44.39271.7NoNo064
131R:R:N414 R:R:R416 10013.26NoNo043
132R:R:R416 R:R:Y180 1009.26NoYes136
133R:R:R156 S:S:T96 1009.06YesYes152
134R:R:K171 R:R:R177 56.39442.48YesYes135
135S:S:D95 S:S:T96 1005.78NoYes042
136R:R:T168 R:R:V185 39.04224.76YesYes177
137L:L:?901 R:R:D295 1002.86YesYes108
138R:R:S169 R:R:T219 38.78183.2YesNo074
139R:R:D188 R:R:T219 14.0694.34YesNo184
140R:R:P187 R:R:R183 27.85795.76YesYes179
141R:R:F181 R:R:R183 64.83036.41YesYes199
142R:R:F190 R:R:Y453 46.85897.22YesYes158
143R:R:D448 R:R:F446 11.77312.39YesYes177
144R:R:D174 R:R:R177 52.068111.91NoYes075
145R:R:D174 R:R:S176 26.0348.83NoNo072
146R:R:F181 R:R:K175 1002.48YesNo096
147R:R:R177 S:S:E213 73.38723.49YesNo056
148R:R:R177 S:S:R243 1002.13YesYes152
149R:R:A182 R:R:G447 17.591.95YesNo167
150R:R:N383 R:R:T184 55.67022.92YesYes089
151R:R:N383 R:R:P431 87.8524.89YesYes087
152R:R:P186 R:R:V185 15.71981.77YesYes187
153R:R:D295 R:R:L319 83.91845.43YesYes184
154R:R:P186 R:R:Y453 76.12374.17YesYes188
155R:R:G449 R:R:P186 17.57532.03NoYes048
156R:R:D448 R:R:G449 15.64211.68YesNo074
157R:R:Q191 R:R:Y216 1003.38YesYes187
158R:R:D295 R:R:Q191 10013.05YesYes188
159R:R:F269 R:R:G220 29.58379.03YesNo176
160R:R:F269 R:R:Y216 1003.09YesYes177
161R:R:M195 R:R:Q191 1004.08YesYes178
162R:R:F269 R:R:M195 1009.95YesYes177
163R:R:I317 R:R:Y453 1004.84YesYes168
164R:R:M195 R:R:V292 1004.56YesYes177
165R:R:F224 R:R:F269 1002.14YesYes177
166R:R:F224 R:R:V207 1002.62YesYes178
167R:R:I233 R:R:V207 20.68133.07YesYes168
168R:R:W204 R:R:W487 20.74165.62YesYes197
169R:R:V265 R:R:V292 1001.6YesYes187
170R:R:V207 R:R:V265 1003.21YesYes188
171R:R:A236 R:R:S208 1001.71YesYes1588
172R:R:L257 R:R:S208 1006.01NoYes1578
173R:R:E239 R:R:L257 1007.95NoNo057
174R:R:E239 R:R:V210 1008.56NoYes055
175R:R:V210 R:R:V241 1001.6YesYes156
176R:R:S212 R:R:V241 1003.23YesYes166
177R:R:R271 R:R:S212 1003.95YesYes156
178R:R:E239 R:R:V253 1008.56NoNo055
179R:R:V241 R:R:V253 1001.6YesNo065
180R:R:T270 R:R:V210 1001.59YesYes145
181R:R:S212 R:R:T270 1004.8YesYes164
182R:R:D274 R:R:V241 1005.84YesYes146
183R:R:D274 R:R:R271 1004.76YesYes145
184R:R:D274 R:R:T270 1004.34YesYes144
185R:R:D274 R:R:E273 1002.6YesYes141
186R:R:A236 R:R:Y206 1006.67YesYes1589
187R:R:A263 R:R:S208 1001.71YesYes1578
188R:R:A263 R:R:Y206 1002.67YesYes1579
189R:R:C500 R:R:Y206 1005.38NoYes099
190R:R:F250 R:R:L278 14.85724.87YesYes135
191S:S:E222 S:S:I221 10.96374.1NoYes065
192R:R:C518 R:R:C519 1001.82NoNo099
193R:R:C500 R:R:C519 1007.28NoNo099
194R:R:M245 R:R:V241 23.48523.04YesYes136
195R:R:A249 R:R:M245 11.80593.22NoYes043
196R:R:E277 R:R:F250 17.697810.49NoYes023
197R:R:F289 R:R:W291 10013.03NoYes067
198R:R:A287 R:R:F289 17.6292.77YesNo046
199R:R:F289 R:R:R264 1002.14NoNo066
200R:R:R264 R:R:S498 1002.64NoNo069
201R:R:S498 R:R:V265 1003.23NoYes098
202R:R:S302 R:R:V303 62.4671.62NoYes114
203R:R:V303 R:R:W297 87.913915.94YesYes146
204R:R:W297 R:R:Y468 16.623810.61YesYes164
205R:R:F380 R:R:M379 94.20857.46YesYes068
206R:R:M379 R:R:Y322 35.550510.78YesYes083
207R:R:R433 R:R:Y322 20.76413.09YesYes133
208R:R:I378 R:R:Q374 11.79462.74YesYes175
209R:R:F345 R:R:P336 11.50752.89YesYes146
210R:R:F345 R:R:W349 11.95422YesYes148
211R:R:A391 R:R:L418 32.27751.58NoYes187
212R:R:A391 R:R:F422 35.16134.16NoYes184
213R:R:H393 R:R:R397 1005.64NoNo073
214R:R:N394 R:R:R397 86.06032.41NoNo043
215R:R:D421 R:R:N394 64.54535.39NoNo054
216R:R:N414 R:R:R417 1003.62NoNo046
217R:R:M395 R:R:R417 1002.48YesNo156
218R:R:C400 R:R:P401 1001.88YesNo033
219R:R:C400 R:R:T403 1001.69YesNo133
220R:R:C400 R:R:C407 1005.46YesNo137
221R:R:D421 R:R:N425 43.03029.42NoNo055
222R:R:L424 R:R:N425 21.51519.61NoNo055
223R:R:D429 R:R:R433 11.865313.1NoYes053
224R:R:I485 R:R:W487 12.39698.22YesYes177
225R:R:C518 R:R:E516 1003.04NoNo094
226R:R:E516 S:S:G515 1001.64NoNo046
227S:S:G515 S:S:P514 1002.03NoYes065
228R:R:P514 S:S:P514 1001.95NoYes055
229R:R:P514 R:R:Q513 1001.58NoNo055
230R:R:F535 R:R:Q513 1005.86NoNo025
231R:R:D533 R:R:F535 1003.58NoNo072
232R:R:E516 S:S:E516 1006.34NoYes044
233S:S:E516 S:S:P514 1007.86YesYes1945
234R:R:G515 S:S:E516 1001.64NoYes064
235R:R:G515 R:R:P514 1002.03NoNo065
236R:R:F535 R:R:T536 1007.78NoNo024
237R:R:C537 R:R:T536 1001.69YesNo1094
238R:R:C537 R:R:E529 1009.12YesYes1098
239R:R:E529 R:R:Y528 1006.73YesYes1088
240R:R:D533 R:R:L532 10013.57NoNo076
241R:R:L532 R:R:Y530 10015.24NoNo3167
242R:R:P546 R:R:Y530 1002.78NoNo087
243R:R:P546 R:R:W545 1002.7NoNo086
244R:R:W545 R:R:Y528 1001.93NoYes068
245R:R:E555 R:R:W545 1002.18NoNo036
246R:R:E555 R:R:V717 1007.13NoYes038
247R:R:K707 R:R:V717 1007.59YesYes028
248R:R:E708 R:R:V717 1002.85YesYes678
249R:R:K707 R:R:L719 1004.23YesNo027
250R:R:L719 R:R:P627 1008.21NoYes679
251R:R:E708 R:R:Y787 1002.24YesNo675
252R:R:Q790 R:R:Y787 1002.25YesNo075
253R:R:Q790 R:R:T793 74.70042.83YesNo078
254R:R:T793 R:R:V789 69.94371.59NoYes085
255R:R:G802 R:R:Y617 13.10784.35NoYes788
256R:R:G802 R:R:S801 24.7111.86NoNo089
257R:R:S801 R:R:W773 25.13788.65NoYes099
258R:R:W773 W:W:?902 1009.8YesYes690
259R:R:F780 W:W:?902 10015.25NoYes080
260R:R:F780 R:R:Q790 10019.91NoYes087
261R:R:G802 R:R:V613 11.20531.84NoYes788
262R:R:V613 R:R:V805 11.2683.21YesNo087
263R:R:T769 R:R:V805 1001.59YesNo087
264R:R:T769 R:R:W773 1004.85YesYes089
265R:R:S784 W:W:?902 1003.52NoYes660
266R:R:Q790 R:R:S784 1008.66YesNo076
267R:R:L609 R:R:V805 1004.47YesNo087
268R:R:L609 R:R:L809 1008.3YesNo088
269R:R:T582 R:R:V613 15.18783.17YesYes778
270R:R:L610 R:R:T582 22.18212.95YesYes797
271R:R:L610 R:R:V585 12.19852.98YesYes796
272R:R:F589 R:R:L610 10.16142.44YesYes799
273R:R:C606 R:R:L809 1001.59NoNo098
274A:A:L348 R:R:F756 19.96943.65YesYes1299
275A:A:L348 A:A:L353 1005.54YesNo1297
276A:A:L353 R:R:R656 1006.07NoYes1278
277R:R:L605 R:R:R656 1004.86YesYes088
278R:R:L605 R:R:T652 1007.37YesNo087
279R:R:C683 R:R:T652 1001.69YesNo077
280R:R:C683 R:R:S648 1003.44YesNo079
281R:R:I687 R:R:S648 1004.64NoNo079
282R:R:I687 R:R:V645 1004.61NoNo077
283R:R:T641 R:R:V645 1001.59YesNo067
284R:R:G638 R:R:T641 1003.64NoYes066
285R:R:G638 R:R:M619 1001.75NoYes067
286R:R:M619 R:R:R635 1003.72YesYes678
287R:R:P627 R:R:R635 1004.32YesYes698
288R:R:Q679 R:R:R656 10018.69NoYes088
289R:R:Q679 R:R:T652 1005.67NoNo087
290R:R:I687 R:R:L691 1002.85NoNo075
291R:R:L691 R:R:T641 1004.42NoYes056
292R:R:K653 R:R:L605 1005.64NoYes098
293R:R:C606 R:R:K653 1001.62NoNo099
294R:R:L609 R:R:L650 12.34574.15YesNo088
295A:A:C351 R:R:R656 10.57466.96YesYes1248
296A:A:L348 R:R:I660 1005.71YesYes1299
297R:R:A759 R:R:F756 12.29724.16NoYes099
298A:A:C351 R:R:I674 12.10791.64YesNo046
299R:R:I674 R:R:R659 10.12147.52NoYes067
300A:A:N347 R:R:R659 10.64893.62NoYes1287
301A:A:I344 R:R:I660 1005.89NoYes069
302R:R:A759 R:R:E754 10.76713.02NoNo098
303A:A:T340 R:R:A664 1003.36NoNo067
304A:A:I344 R:R:A664 1003.25NoNo067
305A:A:L194 R:R:G667 11.41621.71NoYes545
306A:A:F336 A:A:L194 12.09313.65YesNo584
307A:A:F336 A:A:T340 1005.19YesNo086
308A:A:F196 A:A:V34 74.46163.93YesYes575
309A:A:F196 A:A:F336 1006.43YesYes578
310A:A:T219 A:A:V34 24.18654.76YesYes575
311R:R:T783 R:R:V789 68.42561.59NoYes075
312R:R:T783 R:R:V782 68.1221.59NoYes078
313R:R:V782 S:S:T783 53.02861.59YesYes2387
314S:S:Q790 S:S:T783 52.42712.83YesYes077
315S:S:F780 S:S:Q790 21.123614.05NoYes087
316S:S:F780 S:S:M794 15.83296.22NoNo1489
317S:S:F623 S:S:M794 16.07288.71NoNo089
318S:S:F623 S:S:M619 15.55214.98NoYes087
319S:S:C616 S:S:M619 18.38651.62NoYes067
320S:S:C616 S:S:C646 17.13031.82NoYes066
321S:S:I739 S:S:M766 28.68365.83NoYes089
322S:S:C770 S:S:I739 45.68041.64NoNo078
323S:S:C770 S:S:I771 46.20661.64NoNo078
324R:R:I772 S:S:I771 56.39594.42NoNo088
325R:R:I772 R:R:V804 57.97169.22NoNo087
326R:R:T769 R:R:V804 59.02284.76YesNo087
327R:R:V782 S:S:V789 13.58281.6YesNo085
328S:S:E100 S:S:H97 20.98612.46NoYes143
329S:S:F158 S:S:I160 26.53762.51YesYes166
330S:S:I160 S:S:L155 14.498614.27YesNo066
331S:S:A86 S:S:M65 10.5161.61YesYes179
332S:S:F38 S:S:M65 25.00327.46YesYes189
333S:S:F38 S:S:L62 66.76384.87YesYes185
334S:S:A86 S:S:G85 15.76811.95YesNo178
335S:S:G30 S:S:G85 13.1472.11YesNo198
336S:S:I160 S:S:P161 14.44253.39YesYes169
337S:S:L418 S:S:P161 32.85926.57YesYes179
338S:S:L34 S:S:L84 13.115111.07YesNo179
339S:S:I140 S:S:L34 15.70527.14YesYes177
340S:S:G35 S:S:G36 11.76112.11YesYes198
341S:S:L155 S:S:Q162 19.61617.99NoYes068
342S:S:G141 S:S:Q162 13.05974.93YesYes088
343S:S:Q162 S:S:V151 13.05085.73YesYes085
344S:S:D104 S:S:Q101 13.05333.92NoYes145
345S:S:F38 S:S:R61 1002.14YesYes184
346S:S:I140 S:S:Y165 15.8073.63YesYes178
347S:S:P39 S:S:S91 10.48243.56YesYes156
348S:S:K43 S:S:S93 20.90853.06YesNo131
349S:S:R243 S:S:R271 10010.66YesYes125
350S:S:R271 S:S:Y144 41.718419.55YesYes153
351S:S:C50 S:S:H97 20.99132.95NoYes193
352S:S:C92 S:S:H97 20.99137.37YesYes183
353S:S:K94 S:S:T96 1004.5NoYes132
354S:S:D49 S:S:H97 83.857712.61NoYes113
355S:S:D49 S:S:K94 10015.21NoNo113
356S:S:K43 S:S:K94 1005.75YesNo133
357S:S:L62 S:S:N342 38.07592.75YesYes157
358S:S:F345 S:S:N342 30.217810.87YesYes147
359S:S:E63 S:S:F331 10.47164.66YesYes186
360S:S:F331 S:S:F348 31.40963.22YesYes166
361S:S:F348 S:S:R352 15.70775.34YesYes163
362S:S:K171 S:S:Y178 1003.58NoYes036
363S:S:K171 S:S:T219 1004.5NoYes034
364S:S:F456 S:S:Y468 15.72687.22YesYes154
365S:S:E301 S:S:Y468 23.79934.49NoYes134
366S:S:E301 S:S:E373 15.938715.22NoNo034
367S:S:I149 S:S:L172 77.2415.71YesYes057
368S:S:F181 S:S:Q162 46.95814.05YesYes098
369S:S:R57 S:S:S272 21.19953.95YesNo142
370S:S:G296 S:S:R57 27.33673NoYes054
371S:S:L300 S:S:R57 21.216812.15YesYes154
372S:S:R156 S:S:Y180 21.8884.12YesYes156
373S:S:Y180 S:S:Y419 29.53747.94YesYes165
374S:S:F443 S:S:T184 18.43832.59YesYes189
375S:S:F380 S:S:T184 89.95616.49YesYes169
376S:S:E375 S:S:K377 1004.05YesYes153
377S:S:F428 S:S:Y386 15.84912.06YesYes186
378S:S:R71 S:S:Y386 18.30033.09YesYes176
379S:S:F327 S:S:F67 13.12842.14YesYes187
380S:S:I378 S:S:R61 1002.51YesYes174
381S:S:F327 S:S:I378 10015.07YesYes187
382S:S:F327 S:S:Y330 13.07982.06YesYes188
383S:S:I378 S:S:Q60 83.67674.12YesYes177
384S:S:F327 S:S:F372 15.74814.29YesYes185
385S:S:F372 S:S:Q374 15.7258.2YesYes155
386S:S:I378 S:S:Q374 23.57256.86YesYes175
387S:S:F372 S:S:Q60 15.70529.37YesYes157
388S:S:E63 S:S:L334 11.78443.98YesNo185
389S:S:D326 S:S:F432 13.03065.97YesYes144
390S:S:R71 S:S:R74 18.24057.46YesNo074
391S:S:F428 S:S:H390 36.580728.28YesNo086
392S:S:H390 S:S:L78 33.955715.43NoYes067
393S:S:H393 S:S:L78 20.99383.86NoYes077
394S:S:H393 S:S:L79 13.12613.86NoNo079
395S:S:L418 S:S:M395 18.39455.65YesYes175
396S:S:L79 S:S:P80 10.49111.64NoNo098
397S:S:L399 S:S:M395 10.4672.83NoYes135
398S:S:L172 S:S:S148 13.04193YesYes177
399S:S:F181 S:S:S148 13.04765.28YesYes197
400S:S:A98 S:S:V147 23.47183.39YesYes164
401S:S:D146 S:S:D95 1006.65YesNo054
402S:S:L172 S:S:R183 92.79323.64YesYes179
403S:S:F181 S:S:R183 65.36797.48YesYes199
404S:S:K175 S:S:Y419 89.96512.39NoYes165
405S:S:D448 S:S:K175 91.23472.77YesNo176
406S:S:T184 S:S:V185 90.00951.59YesYes197
407S:S:D448 S:S:P187 1008.05YesYes177
408S:S:N383 S:S:T184 39.10872.92YesYes189
409S:S:F428 S:S:V441 54.78829.18YesYes186
410S:S:T184 S:S:V441 96.49121.59YesYes196
411S:S:F380 S:S:L319 1007.31YesYes164
412S:S:F190 S:S:P187 1005.78YesYes157
413S:S:P186 S:S:Y453 92.47328.34YesYes188
414S:S:G220 S:S:T219 1001.82NoYes164
415S:S:F190 S:S:W474 1003.01YesYes156
416S:S:F269 S:S:G220 1006.02YesNo176
417S:S:S294 S:S:Y216 13.18886.36NoYes087
418S:S:F269 S:S:S294 14.42289.25YesNo078
419S:S:E197 S:S:W474 10015.27YesYes166
420S:S:K193 S:S:W474 1006.96YesYes136
421S:S:K193 S:S:R231 1006.19YesYes134
422S:S:E197 S:S:R231 1005.82YesYes164
423S:S:F269 S:S:V267 68.05132.62YesYes176
424S:S:F224 S:S:F269 67.90153.22YesYes177
425S:S:F224 S:S:L199 82.25973.65YesYes176
426S:S:F202 S:S:W204 26.14215.03YesYes189
427S:S:L199 S:S:V267 80.95452.98YesYes166
428S:S:I233 S:S:L199 1002.85YesYes166
429S:S:I233 S:S:R200 1003.76YesYes164
430S:S:R200 S:S:R231 1006.4YesYes144
431S:S:R200 S:S:T205 1002.59YesNo047
432S:S:W204 S:S:W487 27.49464.69YesYes197
433S:S:S498 S:S:W204 72.94473.71NoYes199
434S:S:C234 S:S:T205 1001.69NoNo097
435S:S:A263 S:S:S498 83.46771.71YesNo179
436S:S:A263 S:S:Y206 1004YesYes179
437S:S:C500 S:S:Y206 1009.41NoYes099
438S:S:A263 S:S:S208 1001.71YesYes178
439S:S:E213 S:S:G242 78.57433.27NoNo063
440S:S:G242 S:S:M245 83.77233.49NoYes033
441S:S:M245 S:S:V241 93.8336.09YesYes136
442S:S:V210 S:S:V241 1001.6YesYes156
443S:S:E239 S:S:V210 1002.85YesYes055
444S:S:E239 S:S:T237 1005.64YesNo056
445S:S:S208 S:S:T237 1003.2YesNo086
446S:S:R271 S:S:S212 1003.95YesYes156
447S:S:S212 S:S:V241 1003.23YesYes166
448S:S:D274 S:S:R271 1004.76YesYes145
449S:S:D274 S:S:V241 1005.84YesYes146
450S:S:S212 S:S:T270 1003.2YesYes164
451S:S:T270 S:S:V210 1001.59YesYes145
452S:S:D274 S:S:T270 1005.78YesYes144
453S:S:E239 S:S:L257 1002.65YesYes057
454S:S:L257 S:S:S208 1006.01YesYes078
455S:S:I221 S:S:T209 18.73247.6YesYes056
456S:S:G214 S:S:R243 20.83074.5NoYes062
457S:S:C234 S:S:C518 1007.28NoYes099
458S:S:L279 S:S:S307 15.76163YesYes153
459S:S:F250 S:S:L278 11.08137.31YesNo035
460S:S:L278 S:S:W291 16.26594.56NoYes057
461S:S:L279 S:S:W291 41.821910.25YesYes157
462S:S:S282 S:S:W291 15.92556.18YesYes147
463S:S:A281 S:S:V254 20.90421.7NoYes155
464S:S:A281 S:S:R284 10.44324.15NoYes153
465S:S:E277 S:S:F250 10.44979.33NoYes023
466S:S:L285 S:S:V254 20.92324.47NoYes145
467S:S:L285 S:S:R255 10.46198.5NoNo143
468S:S:F289 S:S:W291 10015.03YesYes167
469S:S:F289 S:S:L258 26.05094.87YesNo163
470S:S:A287 S:S:F289 33.85732.77YesYes146
471S:S:A266 S:S:W291 1002.59NoYes167
472S:S:A275 S:S:L268 26.23661.58NoYes055
473S:S:A266 S:S:L268 96.34831.58NoYes165
474S:S:S272 S:S:V303 31.593.23NoYes124
475S:S:L300 S:S:V303 41.99772.98YesYes154
476S:S:A275 S:S:V303 23.82811.7NoYes054
477S:S:A310 S:S:L279 10.47531.58YesYes135
478S:S:A310 S:S:S282 15.66591.71YesYes134
479S:S:A311 S:S:W297 15.69152.59YesYes166
480S:S:A310 S:S:Q283 13.08874.55YesNo133
481S:S:G313 S:S:W487 11.82892.81NoYes087
482S:S:E312 S:S:G313 10.4776.55YesNo058
483S:S:V304 S:S:W297 15.61573.68YesYes146
484S:S:I315 S:S:T457 15.79294.56YesYes158
485S:S:F380 S:S:M379 36.61757.46YesYes168
486S:S:M379 S:S:N383 19.54457.01YesYes188
487S:S:M379 S:S:Y322 15.773514.37YesYes183
488S:S:F331 S:S:L367 83.68493.65YesNo166
489S:S:F372 S:S:Q332 31.456211.71YesNo054
490S:S:Q332 S:S:R368 23.59224.67NoNo041
491S:S:F345 S:S:P336 13.14388.67YesYes146
492S:S:F345 S:S:W349 14.50145.01YesYes148
493S:S:F353 S:S:L367 20.93733.65YesNo176
494S:S:C355 S:S:W349 32.79022.61YesYes188
495S:S:R352 S:S:V370 10.48363.92YesNo134
496S:S:F353 S:S:V370 10.47212.62YesNo174
497S:S:C355 S:S:D361 26.24676.22YesNo081
498S:S:D361 S:S:S356 19.6851.47NoNo014
499S:S:Q359 S:S:S356 13.123410.11NoNo014
500S:S:P371 S:S:V370 10.47783.53NoNo054
501S:S:P431 S:S:Y386 39.07028.34YesYes176
502S:S:P431 S:S:V441 36.48711.77YesYes176
503S:S:N383 S:S:P431 54.70894.89YesYes187
504S:S:L484 S:S:V471 13.14544.47NoYes037
505S:S:G472 S:S:V471 13.09721.84NoYes097
506S:S:F535 S:S:Q513 23.015.86NoYes025
507S:S:F535 S:S:S511 22.63322.64NoYes025
508S:S:C500 S:S:C519 1007.28NoNo099
509S:S:C519 S:S:E516 1009.12NoYes1994
510S:S:E534 S:S:S511 12.449810.06NoYes065
511S:S:E534 S:S:Q506 12.072614.02NoNo065
512S:S:Q506 S:S:R531 11.69554.67NoNo057
513S:S:P546 S:S:R531 10.187111.53NoNo087
514S:S:D725 S:S:Q790 30.71455.22NoYes047
515S:S:D725 S:S:R724 29.490217.87NoYes948
516S:S:R636 S:S:R724 15.0794.26YesYes988
517S:S:K707 S:S:T705 15.83274.5NoYes024
518S:S:E708 S:S:K707 12.95422.7NoNo072
519S:S:E708 S:S:Y544 11.51484.49NoNo074
520S:S:F554 S:S:Y544 10.075512.38NoNo034
521S:S:V789 S:S:W567 12.97063.68NoNo055
522S:S:G763 S:S:M766 15.42641.75NoYes1199
523S:S:G763 S:S:I762 14.90083.53NoYes1199
524S:S:I739 S:S:Y647 16.54516.92NoYes086
525A:A:D9 B:B:T86 27.26871.45NoYes046
526B:B:D83 B:B:T86 36.33287.23YesYes2786
527B:B:D83 B:B:L69 81.76195.43YesNo085
528B:B:L69 B:B:Y105 1003.52NoYes056
529B:B:V112 B:B:Y105 1002.52NoYes886
530B:B:V112 B:B:Y124 1003.79NoYes886
531B:B:L95 B:B:Y124 1008.21YesYes886
532B:B:L95 B:B:S97 1003YesNo888
533B:B:D118 B:B:S97 1008.83NoNo098
534B:B:D118 B:B:G116 1001.68NoNo099
535B:B:G116 B:B:M101 1001.75NoNo099
536B:B:M101 B:B:Y145 1005.99NoYes098
537A:A:Q204 B:B:Y145 1002.25YesYes298
538A:A:Q204 A:A:W211 10010.95YesYes299
539A:A:L39 A:A:W211 1002.28YesYes299
540A:A:F223 A:A:L39 1002.44YesYes299
541A:A:F223 A:A:F250 1008.57YesYes299
542A:A:F250 A:A:I319 1002.51YesNo295
543A:A:I319 A:A:K314 1004.36NoNo253
544A:A:K314 A:A:N311 1009.79NoNo038
545A:A:K317 A:A:N311 1006.99NoNo078
546A:A:K317 A:A:R313 1008.66NoYes074
547A:A:R313 A:A:T316 10015.52YesNo4443
548A:A:K349 A:A:T316 1004.5NoNo053
549A:A:F354 A:A:K349 1004.96NoNo055
550A:A:F354 A:A:L348 1002.44NoYes059
551B:B:S122 B:B:Y124 1005.09NoYes886
552B:B:I120 B:B:S122 1003.1YesNo068
553B:B:D118 B:B:I120 10011.2NoYes096
554A:A:S206 B:B:Y145 1006.36YesYes288
555A:A:S206 A:A:W211 1002.47YesYes289
556B:B:L117 B:B:Y145 1003.52NoYes098
557A:A:W211 B:B:L117 1002.28YesNo099
558A:A:D9 A:A:E8 18.179210.39NoNo045
559A:A:S16 B:B:K89 72.65314.59NoYes079
560B:B:I80 B:B:K89 72.64567.27YesYes389
561B:B:H54 B:B:I80 84.75911.93YesYes398
562B:B:H54 B:B:I58 1009.28YesYes399
563B:B:G330 B:B:I58 1003.53YesYes359
564B:B:G330 B:B:S316 1001.86YesNo359
565B:B:S316 B:B:W332 1004.94NoYes399
566B:B:K57 B:B:W332 10018.57YesYes399
567B:B:K57 B:B:Q75 1002.71YesNo399
568B:B:Q75 B:B:W99 1008.76NoYes099
569A:A:F215 B:B:W99 10010.02NoYes099
570A:A:F215 A:A:L37 1008.53NoNo099
571A:A:L37 A:A:L39 1004.15NoYes099
572B:B:K89 B:B:W82 10015.08YesYes399
573B:B:H54 B:B:W82 78.72167.41YesYes399
574B:B:L51 B:B:W82 78.701919.36YesYes399
575B:B:L336 B:B:L51 1009.69YesYes379
576B:B:G330 B:B:L336 1001.71YesYes357
577B:B:W332 B:B:Y59 1008.68YesYes398
578B:B:Q75 B:B:Y59 10018.04NoYes398
579A:A:I221 A:A:L37 1008.56NoNo089
580A:A:I221 A:A:I264 1008.83NoYes086
581A:A:F250 A:A:I264 1007.54YesYes296
582A:A:S16 B:B:N88 54.48992.98NoYes077
583B:B:D83 B:B:N88 27.26886.73YesYes2787
584A:A:D20 B:B:K89 90.834511.06NoYes069
585A:A:D20 A:A:K17 54.50085.53NoNo064
586A:A:K17 A:A:R21 36.33396.19NoNo044
587A:A:M18 A:A:R21 18.16696.2NoNo044
588A:A:I19 B:B:K89 18.16695.82NoYes099
589A:A:D20 B:B:G53 18.16691.68NoNo069
590A:A:D26 B:B:K78 27.27625.53NoYes058
591B:B:K78 B:B:P94 54.539410.04YesNo085
592B:B:I93 B:B:P94 63.62411.69YesNo075
593B:B:I93 B:B:Y124 72.69474.84YesYes876
594A:A:D26 A:A:N22 18.18165.39NoNo054
595A:A:L23 B:B:K89 18.17714.23NoYes069
596A:A:G27 B:B:D76 12.12161.68YesYes2059
597B:B:D76 B:B:S74 36.3452.94YesNo099
598B:B:H54 B:B:S74 42.40229.76YesNo099
599A:A:F199 A:A:K197 21.2444.96YesYes1656
600A:A:F199 B:B:W99 36.41817.04YesYes059
601A:A:L36 A:A:V34 45.78794.47YesYes575
602A:A:L36 A:A:V339 45.76424.47YesNo078
603A:A:F196 A:A:V339 73.34053.93YesNo078
604A:A:F189 A:A:M198 23.64742.49NoYes097
605A:A:F189 A:A:F196 44.620111.79NoYes097
606A:A:A220 A:A:L36 42.42211.58YesYes587
607A:A:A220 A:A:T219 21.16341.68YesYes587
608A:A:I222 A:A:L36 46.39317.14YesYes577
609A:A:L38 A:A:M198 19.15952.83YesYes587
610A:A:C224 A:A:L38 12.76951.59YesYes578
611A:A:C224 A:A:I222 25.53941.64YesYes577
612A:A:C224 A:A:F267 25.20675.59YesYes579
613A:A:F267 A:A:V335 49.08312.62YesNo098
614A:A:V335 A:A:V339 26.11271.6NoNo088
615A:A:V332 A:A:V335 25.973.21NoNo078
616A:A:F191 A:A:V332 27.43410.49YesNo557
617A:A:F191 A:A:F336 31.92117.5YesYes558
618A:A:F223 A:A:L249 10.76227.31YesNo099
619A:A:G40 A:A:S44 13.15091.86NoNo099
620A:A:C224 A:A:S44 18.47411.72YesNo579
621A:A:C224 A:A:N269 38.05363.15YesYes579
622A:A:N269 A:A:T48 22.74642.92YesYes599
623A:A:M53 A:A:Q52 13.60584.08YesNo089
624A:A:F189 A:A:M53 19.79511.2NoYes098
625A:A:N47 A:A:T48 18.18772.92NoYes099
626B:B:G144 B:B:N119 37.87921.7YesYes089
627A:A:Q204 B:B:G144 78.75731.64YesYes098
628B:B:D163 B:B:G144 39.39146.71YesYes098
629A:A:S206 B:B:G162 1001.86YesYes289
630A:A:K210 B:B:Y145 1005.97YesYes298
631B:B:D186 B:B:Y145 81.78782.3YesYes298
632B:B:S147 B:B:Y145 1007.63NoYes098
633A:A:K210 B:B:D228 1002.77YesYes299
634A:A:C214 B:B:M101 45.58551.62NoNo079
635A:A:C214 A:A:H213 40.96574.42NoYes078
636A:A:W258 B:B:W332 12.11026.56YesYes359
637A:A:H213 B:B:R314 27.270911.28YesYes388
638B:B:R314 B:B:W332 36.369123.99YesYes389
639A:A:A220 A:A:S263 13.67663.42YesNo587
640A:A:A220 A:A:I265 27.40061.62YesYes588
641A:A:I222 A:A:I265 18.42615.89YesYes578
642A:A:F267 A:A:I265 18.42553.77YesYes598
643A:A:A220 A:A:V342 18.28331.7YesYes587
644A:A:E308 A:A:F307 99.80062.33YesYes238
645A:A:E308 A:A:K314 1002.7YesNo233
646A:A:E308 A:A:T321 48.38948.47YesYes035
647A:A:N241 A:A:R242 21.89162.41NoYes099
648A:A:C286 A:A:N241 25.01886.3YesNo069
649A:A:C286 A:A:M243 43.77453.24YesNo268
650A:A:F307 A:A:M243 64.0982.49YesNo288
651A:A:L268 A:A:T321 26.13624.42NoYes085
652A:A:F323 A:A:L268 18.449110.96YesNo1748
653A:A:F323 A:A:Q304 18.44973.51YesNo045
654A:A:Q304 A:A:T321 19.986712.76NoYes055
655A:A:C286 A:A:Y230 17.20155.38YesYes268
656A:A:L283 A:A:Y287 28.37684.69YesYes277
657A:A:M243 A:A:Y287 18.76053.59NoYes287
658A:A:M247 A:A:Y287 19.07463.59YesYes267
659A:A:F307 A:A:M247 32.8314.98YesYes286
660A:A:M247 A:A:Q306 12.71535.44YesNo265
661A:A:K257 A:A:W258 13.624213.92NoYes045
662A:A:I265 A:A:Y320 31.93532.42YesYes587
663A:A:F334 A:A:I265 10.67722.51NoYes538
664A:A:A338 A:A:I265 10.62933.25NoYes568
665A:A:F323 A:A:K271 18.44926.2YesYes1745
666A:A:F323 A:A:Y296 12.35.16YesYes1744
667A:A:L283 A:A:Y290 15.76654.69YesYes277
668A:A:Q306 A:A:Y302 11.126112.4NoNo056
669A:A:E298 A:A:Y290 14.2284.49YesYes247
670A:A:K345 A:A:Y320 10.62934.78NoYes557
671A:A:D341 A:A:Y320 10.629311.49NoYes587
672B:B:L30 G:G:V30 1002.98YesYes058
673B:B:L261 G:G:V30 1004.47YesYes058
674B:B:D254 B:B:L261 10013.57YesYes495
675B:B:D254 B:B:N239 1002.69YesNo092
676B:B:N237 B:B:N239 1004.09YesNo052
677B:B:G238 B:B:N237 1003.39NoYes075
678B:B:F234 B:B:G238 1004.52YesNo057
679B:B:F234 B:B:S191 1005.28YesNo258
680B:B:I232 B:B:S191 1003.1YesNo288
681B:B:I232 B:B:T243 1004.56YesYes288
682B:B:S245 B:B:T243 1001.6YesYes298
683B:B:S227 B:B:S245 1003.26YesYes269
684B:B:D228 B:B:S227 1002.94YesYes296
685B:B:F234 B:B:V200 1002.62YesYes256
686B:B:I232 B:B:V200 1006.14YesYes286
687B:B:N239 B:B:R256 1003.62NoNo029
688B:B:R219 B:B:R256 1003.2NoNo059
689B:B:L210 B:B:R219 1004.86YesNo055
690B:B:L210 B:B:V200 1002.98YesYes056
691B:B:A208 B:B:V200 1001.7YesYes266
692B:B:A208 B:B:T243 1001.68YesYes268
693B:B:F241 B:B:V200 10011.8YesYes266
694B:B:F241 B:B:T243 1002.59YesYes268
695B:B:F234 B:B:L255 1002.44YesNo056
696B:B:F241 B:B:L255 1003.65YesNo066
697B:B:L210 B:B:L255 1005.54YesNo056
698B:B:A240 B:B:D254 1004.63YesYes469
699B:B:A240 B:B:L252 1001.58YesYes467
700B:B:A242 B:B:L252 1001.58YesYes447
701B:B:A242 B:B:V276 1001.7YesYes446
702B:B:I273 B:B:V276 1003.07YesYes466
703B:B:G244 B:B:I273 1007.05NoYes056
704B:B:G244 B:B:T243 1001.82NoYes058
705B:B:L252 B:B:Y264 1004.69YesYes475
706B:B:C250 B:B:Y264 1005.38YesYes485
707B:B:C250 B:B:I273 1004.91YesYes486
708B:B:W297 B:B:Y264 10011.58YesYes485
709B:B:W297 B:B:Y289 1009.65YesYes487
710B:B:D291 B:B:Y289 1002.3YesYes487
711B:B:C271 B:B:D291 1007.78NoYes058
712B:B:C271 B:B:G272 1001.96NoNo054
713B:B:D246 B:B:G272 1003.35YesNo094
714B:B:D228 B:B:D246 1003.99YesYes299
715B:B:A208 B:B:G202 1001.95YesYes066
716B:B:G202 B:B:S201 1001.86YesYes069
717B:B:S160 B:B:S201 1001.63YesYes269
718B:B:C148 B:B:S160 1001.72YesYes266
719B:B:C148 B:B:S147 1001.72YesNo069
720B:B:D212 B:B:R219 10015.48NoNo095
721B:B:D212 B:B:E215 10012.99NoNo093
722B:B:E215 B:B:G216 1001.64NoNo034
723B:B:F180 B:B:G216 1004.52YesNo274
724B:B:C166 B:B:F180 1004.19YesYes287
725B:B:C166 B:B:S160 1003.44YesYes286
726B:B:L190 B:B:S201 1004.5YesYes259
727B:B:C148 B:B:L190 1003.17YesYes265
728B:B:C166 B:B:L190 1001.59YesYes285
729B:B:F180 B:B:F199 10010.72YesYes279
730B:B:F199 B:B:L190 1007.31YesYes295
731B:B:L30 B:B:Q32 86.282617.3YesNo2851
732B:B:I33 B:B:Q32 86.28264.12YesNo2831
733B:B:I33 G:G:A34 1003.25YesNo036
734B:B:L261 G:G:A34 1001.58YesNo056
735B:B:L30 G:G:S31 86.28269.01YesNo2859
736G:G:K29 G:G:S31 86.28277.65NoNo049
737G:G:K29 G:G:V30 1004.55NoYes048
738B:B:I33 G:G:S31 86.28263.1YesNo2839
739B:B:M262 B:B:T34 72.67274.52NoYes445
740B:B:M262 B:B:Y264 81.75525.99NoYes445
741B:B:L300 B:B:T34 27.25865.9YesYes465
742B:B:A299 B:B:L300 40.88321.58NoYes456
743B:B:A299 B:B:L252 54.50431.58NoYes457
744B:B:T34 G:G:M38 27.25056.02YesNo454
745B:B:I37 B:B:L300 45.42655.71NoYes426
746B:B:I37 G:G:M38 18.16694.37NoNo424
747B:B:I37 G:G:E42 31.79678.2NoNo021
748B:B:D38 B:B:P39 25.73161.61NoNo011
749B:B:K301 B:B:P39 51.463211.71NoNo051
750B:B:D298 B:B:K301 1004.15NoNo095
751B:B:D298 B:B:R283 10019.06NoYes4599
752B:B:R283 G:G:C41 1002.79YesYes097
753G:G:C41 G:G:L37 1001.59YesYes077
754B:B:L252 G:G:L37 1004.15YesYes477
755B:B:R283 G:G:L51 96.86053.64YesYes096
756G:G:D48 G:G:L51 1009.5YesYes096
757B:B:G324 G:G:D48 1001.68YesYes399
758B:B:G324 B:B:T321 1001.82YesYes397
759B:B:T321 B:B:W63 1009.7YesYes377
760B:B:A328 B:B:W63 1002.59YesYes357
761B:B:A328 B:B:M61 1003.22YesYes356
762B:B:C317 B:B:M61 1006.48YesYes376
763B:B:C317 B:B:S316 1003.44YesNo379
764B:B:G330 B:B:M61 1003.49YesYes356
765B:B:G41 B:B:V40 25.73161.84NoNo013
766B:B:R283 B:B:V40 51.463114.38YesNo4593
767B:B:R304 B:B:W297 13.6394YesYes458
768B:B:I43 B:B:M45 99.88282.92NoNo034
769B:B:L308 B:B:M45 36.36635.65YesNo074
770B:B:C294 B:B:L308 99.93511.59YesYes057
771B:B:C294 B:B:G288 1003.92YesYes457
772B:B:A287 B:B:G288 1001.95YesYes467
773B:B:A287 B:B:I273 1003.25YesYes466
774B:B:A287 B:B:Y289 1004YesYes467
775B:B:M45 G:G:L50 96.87932.83NoYes049
776B:B:G324 G:G:L50 1001.71YesYes399
777B:B:N340 G:G:L50 10010.98NoYes399
778B:B:N340 B:B:R48 1006.03NoYes397
779B:B:I338 B:B:R48 1003.76YesYes357
780B:B:A328 B:B:I338 1001.62YesYes355
781B:B:A305 B:B:I43 66.58841.62NoNo043
782B:B:A305 B:B:V296 96.84651.7NoNo045
783B:B:L284 B:B:V296 72.638914.9YesNo355
784B:B:L284 G:G:L50 96.85285.54YesYes359
785B:B:L286 B:B:V296 72.63615.96YesNo375
786B:B:L286 B:B:V320 48.43042.98YesYes377
787B:B:G324 B:B:V320 60.56761.84YesYes397
788B:B:L286 B:B:V327 48.42255.96YesYes376
789B:B:N340 B:B:V327 60.53374.43NoYes396
790B:B:L308 B:B:R46 18.17371.21YesNo075
791B:B:H311 B:B:K337 54.50895.24YesYes496
792B:B:H311 B:B:T329 54.509310.95YesYes498
793B:B:C294 B:B:T329 72.68151.69YesYes458
794B:B:K337 B:B:W339 54.516110.44YesYes469
795B:B:T329 B:B:W339 72.688.49YesYes489
796B:B:L308 B:B:W339 36.35859.11YesYes079
797B:B:T329 B:B:V315 72.67993.17YesYes487
798B:B:G288 B:B:V315 1001.84YesYes477
799B:B:H311 B:B:S331 27.25516.74YesNo499
800B:B:S331 B:B:V315 81.771.62NoYes497
801B:B:T47 B:B:W339 27.25646.06NoYes439
802B:B:L51 B:B:T87 12.10974.42YesNo395
803B:B:I338 B:B:R49 12.1092.51YesYes357
804B:B:I338 G:G:F61 1005.02YesYes358
805B:B:D333 B:B:F335 27.25753.58YesNo494
806B:B:D333 B:B:S331 45.428210.31YesNo499
807B:B:K337 B:B:T50 54.514112.01YesNo463
808B:B:L51 B:B:L70 12.11552.77YesYes395
809B:B:A328 B:B:L70 24.2171.58YesYes355
810B:B:G115 B:B:T102 12.11441.82YesNo298
811B:B:G115 B:B:G116 13.67672.11YesNo099
812B:B:L146 B:B:S161 81.77073YesYes279
813B:B:G162 B:B:S161 1001.86YesYes299
814B:B:C149 B:B:L146 18.17073.17YesYes287
815B:B:C149 B:B:T159 18.17323.38YesYes289
816B:B:S161 B:B:T159 1001.6YesYes299
817B:B:C148 B:B:R150 36.3436.96YesYes266
818B:B:G64 B:B:W63 36.48042.81NoYes057
819B:B:G64 B:B:Y105 27.3964.35NoYes056
820B:B:S67 B:B:W63 48.45122.47NoYes357
821B:B:S84 B:B:W63 12.11537.41NoYes357
822B:B:L70 B:B:S84 18.16294.5YesNo355
823B:B:A326 B:B:W63 12.11283.89YesYes377
824B:B:A326 B:B:I338 12.10821.62YesYes375
825B:B:D66 B:B:G64 42.39651.68NoNo085
826B:B:D66 B:B:L69 18.1742.71NoNo085
827B:B:F151 B:B:P107 45.42635.78YesNo296
828B:B:A113 B:B:F151 42.41494.16YesYes299
829B:B:A113 B:B:C121 24.23071.81YesYes298
830B:B:C121 B:B:L146 57.54934.76YesYes287
831B:B:F151 B:B:I123 21.22083.77YesYes296
832B:B:C121 B:B:I123 84.81421.64YesYes286
833B:B:A113 B:B:C149 24.24773.61YesYes298
834B:B:C121 B:B:T159 57.5421.69YesYes289
835B:B:F151 B:B:I157 42.425917.58YesYes297
836B:B:I157 B:B:W169 90.85482.35YesYes278
837B:B:T159 B:B:W169 25.744110.92YesYes298
838B:B:H142 B:B:W169 77.21997.41YesYes298
839B:B:H142 B:B:S161 33.321816.74YesYes299
840B:B:H142 B:B:N119 33.30843.83YesYes299
841B:B:D163 B:B:H142 33.30677.56YesYes299
842B:B:P107 B:B:T65 30.28841.75NoNo061
843B:B:D322 B:B:T65 15.14422.89NoNo011
844B:B:D66 B:B:R68 30.28574.76NoYes085
845B:B:R68 B:B:Y85 12.146919.55YesNo054
846B:B:Y85 G:G:F61 36.35748.25NoYes048
847B:B:D323 B:B:S67 36.3458.83YesNo375
848B:B:D323 B:B:T321 36.34465.78YesYes377
849B:B:A73 B:B:L79 13.6291.58NoYes897
850B:B:A73 B:B:V100 31.79613.39NoYes899
851B:B:S97 B:B:V100 54.50441.62NoYes889
852B:B:C114 B:B:L79 27.25411.59YesYes887
853B:B:C114 B:B:V100 18.17131.71YesYes889
854B:B:C114 B:B:L95 18.16793.17YesYes888
855B:B:L79 B:B:V71 27.26674.47YesYes878
856B:B:A73 B:B:C103 13.62841.81NoNo898
857B:B:I81 B:B:V71 18.1653.07YesYes878
858B:B:H91 B:B:V133 27.24988.3YesYes854
859B:B:V133 B:B:Y124 63.58393.79YesYes846
860B:B:I81 B:B:L126 18.1652.85YesYes875
861B:B:L126 B:B:V133 18.17975.96YesYes854
862B:B:L126 B:B:V112 18.16585.96YesNo858
863B:B:Y85 G:G:P60 12.110716.69NoNo049
864G:G:N59 G:G:P60 12.10926.52YesNo099
865G:G:F61 G:G:N59 60.54664.83YesYes389
866B:B:G109 B:B:S108 18.28871.86NoNo056
867B:B:A106 B:B:S108 30.35741.71NoNo066
868B:B:A106 B:B:F151 45.49074.16NoYes269
869B:B:I123 B:B:Y111 33.34883.63YesYes264
870B:B:N125 B:B:Y111 15.163316.28NoYes244
871B:B:I123 B:B:I171 21.24355.89YesNo266
872B:B:I157 B:B:I171 42.40815.89YesNo276
873B:B:N125 B:B:T128 12.13074.39NoNo043
874B:B:L192 B:B:R150 27.25586.07YesYes256
875B:B:L190 B:B:L192 27.26752.77YesYes255
876B:B:L152 B:B:L192 45.43475.54YesYes235
877B:B:L152 B:B:Q156 27.25976.65YesYes235
878B:B:Q156 B:B:V213 13.63992.87YesNo254
879B:B:F199 B:B:V213 18.18792.62YesNo294
880B:B:D153 B:B:Q156 13.63667.83NoYes055
881B:B:D170 B:B:N155 36.39245.39NoNo093
882B:B:I171 B:B:N155 54.56374.25NoNo063
883B:B:L168 B:B:Q156 13.636810.65NoYes065
884B:B:C166 B:B:W211 18.17265.22YesYes288
885B:B:S201 B:B:W211 18.22553.71YesYes298
886B:B:D205 B:B:H183 31.81335.04YesYes299
887B:B:D205 B:B:G185 54.52455.03YesNo295
888B:B:D186 B:B:G185 63.61291.68YesNo295
889B:B:T177 B:B:T178 13.67444.71NoNo044
890B:B:F180 B:B:T178 27.27396.49YesNo274
891B:B:D170 B:B:T173 27.27034.34NoNo095
892B:B:H183 B:B:K209 18.171718.34YesYes296
893B:B:D205 B:B:S207 13.62997.36YesNo295
894B:B:A193 B:B:F234 95.38875.55NoYes245
895B:B:F234 B:B:P194 31.79652.89YesNo254
896B:B:A193 B:B:D195 63.59334.63NoNo045
897B:B:D195 B:B:L198 81.75212.71NoNo053
898B:B:L198 B:B:L210 81.76715.54NoYes035
899B:B:D212 B:B:L198 40.88558.14NoNo093
900B:B:D195 B:B:R197 72.66943.57NoNo055
901B:B:C218 B:B:W211 27.26135.22NoYes258
902B:B:E215 B:B:M217 13.63258.12NoNo033
903B:B:F222 B:B:F241 13.647511.79NoYes286
904B:B:G224 B:B:R251 18.18031.5NoYes068
905B:B:H225 B:B:R251 18.170429.34YesYes298
906B:B:H225 B:B:S245 22.715112.55YesYes299
907B:B:R251 B:B:T243 18.187818.11YesYes288
908B:B:D247 B:B:T249 13.632110.12YesNo096
909B:B:D247 B:B:S227 22.71868.83YesYes296
910B:B:A231 B:B:S275 16.64973.42NoNo058
911B:B:S275 B:B:T274 21.22353.2NoNo088
912B:B:R314 B:B:T274 31.78336.47YesNo388
913B:B:C317 B:B:S275 12.13961.72YesNo078
914B:B:C233 B:B:V276 27.25058.54NoYes436
915B:B:C233 B:B:F278 22.71518.38NoYes437
916B:B:A242 B:B:F278 22.70734.16YesYes447
917B:B:F278 B:B:L285 1007.31YesYes476
918B:B:L285 B:B:V276 27.25054.47YesYes466
919B:B:C250 B:B:L285 27.24861.59YesYes486
920B:B:A287 B:B:L285 54.53131.58YesYes466
921B:B:L285 B:B:W297 27.25484.56YesYes468
922B:B:F235 B:B:N237 63.608912.08YesYes465
923B:B:F235 B:B:F278 63.60179.65YesYes467
924B:B:F278 B:B:P236 63.5882.89YesYes477
925B:B:F235 B:B:G282 63.58923.01YesNo469
926B:B:G282 B:B:P236 31.79124.06NoYes497
927B:B:N237 G:G:Y40 10013.96YesYes456
928B:B:D291 B:B:I269 18.17425.6YesYes484
929B:B:A257 B:B:D254 86.28254.63NoYes479
930B:B:D254 G:G:A33 86.28253.09YesNo497
931B:B:Q259 G:G:V30 86.28268.6NoYes068
932B:B:D290 B:B:R314 10.675525.01NoYes368
933B:B:G288 B:B:L318 18.20353.42YesYes476
934B:B:G324 B:B:S279 12.10721.86YesYes399
935B:B:D323 B:B:K280 48.48832.77YesNo371
936B:B:G324 B:B:K280 24.23881.74YesNo391
937B:B:K280 G:G:E47 36.40746.75NoNo013
938B:B:S281 G:G:D48 24.30555.89YesYes099
939G:G:H44 G:G:Y40 95.478326.13YesYes066
940B:B:S281 G:G:A45 12.11341.71YesNo094
941G:G:A45 G:G:L51 12.10981.58NoYes046
942B:B:D291 B:B:N293 22.72525.39YesNo085
943B:B:N313 B:B:W332 12.111110.17NoYes379
944B:B:F292 B:B:R314 10.59832.14NoYes348
945B:B:A305 B:B:G306 81.71721.95NoNo044
946B:B:M325 G:G:F61 12.12622.49NoYes358
947B:B:G324 G:G:P49 12.1082.03YesNo397
948G:G:A35 G:G:K32 86.28263.21NoNo025
949G:G:K29 G:G:K32 1001.44NoNo045
950G:G:D36 G:G:K32 86.282616.59NoNo055
951G:G:A43 G:G:H44 63.59261.46NoYes046
952G:G:A43 G:G:K46 31.79631.61NoNo041
953G:G:P55 G:G:V54 12.11163.53NoNo356
954G:G:N59 G:G:V54 36.33472.96YesNo396
955G:G:E58 G:G:V54 12.11162.85NoNo356
956R:R:C407 R:R:D408 1001.56NoNo072
957A:A:A12 B:B:N88 54.49831.56NoYes047
958R:R:A409 R:R:D408 1001.54NoNo032
959S:S:L300 S:S:S302 10.42511.5YesNo051
960B:B:K301 B:B:N35 25.73161.4NoNo051
961A:A:A12 A:A:R15 27.24921.38NoNo045
962R:R:K420 R:R:Y419 54.3421.19NoYes035
963R:R:K23 R:R:Q101 19.58932.71NoYes135
964L:L:?901 R:R:R61 1008.52YesYes104
965L:L:?901 R:R:S143 1002.11YesYes104
966L:L:?901 R:R:A166 1005.53YesYes105
967L:L:?901 R:R:Y144 1004.11YesYes103
968R:R:F327 R:R:I378 35.872615.07YesYes187
969S:S:R177 S:S:Y178 26.279814.4NoYes056
970R:R:A102 R:R:L155 42.1721.58YesYes166
971S:S:F158 S:S:L110 10.50532.44YesNo063
972R:R:Q159 R:R:Y180 44.24716.76NoYes146
973R:R:L319 R:R:Y453 10010.55YesYes148
974R:R:F190 R:R:P187 37.48247.22YesYes157
975R:R:G220 R:R:T219 27.63291.82NoNo164
976R:R:L300 R:R:V303 24.49154.47YesYes154
977S:S:C518 S:S:E516 1004.56YesYes1994
978S:S:D146 S:S:V147 41.87165.84YesYes154
979S:S:F224 S:S:T209 12.56322.59YesYes176
980S:S:T209 S:S:V267 12.68296.35YesYes166
981S:S:W291 S:S:W297 1006.56YesYes176
982S:S:L268 S:S:W297 62.60122.28YesYes156
983S:S:R276 S:S:V303 10.42442.62NoYes024
984R:R:I160 R:R:L155 25.06158.56NoYes066
985R:R:L406 R:R:V82 11.78717.45YesYes125
986R:R:M388 R:R:P161 1001.68YesYes169
987R:R:F181 R:R:Q162 42.717310.54YesYes198
988R:R:F181 R:R:L172 35.138115.83YesYes197
989R:R:A182 R:R:Y419 17.63042.67YesYes165
990R:R:D448 R:R:G447 23.5611.68YesNo177
991R:R:F380 R:R:T184 10010.38YesYes069
992R:R:M379 R:R:N383 55.67315.61YesYes088
993R:R:W291 R:R:W297 1003.75YesYes176
994S:S:D146 S:S:R271 1003.57YesYes155
995S:S:E273 S:S:Y144 20.82958.98NoYes113
996S:S:A266 S:S:L257 1001.58NoYes067
997S:S:F289 S:S:L257 1002.44YesYes067
998R:R:H56 R:R:Q60 17.61774.95YesYes137
999R:R:F327 R:R:Y330 14.80722.06YesYes188
1000R:R:N153 R:R:R156 31.3554.82YesYes155
1001R:R:A263 R:R:S498 1001.71YesNo079
1002S:S:A236 S:S:S208 1001.71YesYes188
1003S:S:V303 S:S:W297 70.70238.58YesYes146
1004S:S:A311 S:S:L279 10.42653.15YesYes165
1005R:R:G35 R:R:G36 62.51962.11YesYes198
1006R:R:F105 R:R:H87 85.931210.18YesYes164
1007R:R:H87 R:R:V25 58.57182.77YesNo144
1008R:R:F38 R:R:I88 82.439912.56YesYes187
1009R:R:F38 R:R:R61 1002.14YesYes184
1010R:R:C50 R:R:H41 70.472910.32NoYes198
1011R:R:G44 R:R:K43 1001.74YesYes143
1012R:R:E55 R:R:F348 50.09922.33YesYes156
1013R:R:F345 R:R:F348 34.40394.29YesYes146
1014R:R:R61 R:R:V381 1003.92YesYes147
1015R:R:F432 R:R:Y386 46.96557.22YesYes146
1016R:R:G142 R:R:V147 69.14191.84YesYes154
1017R:R:T137 R:R:V413 11.7139.52NoNo043
1018S:S:L99 S:S:Q150 41.697414.64YesNo155
1019R:R:R183 R:R:V185 48.36683.92YesYes197
1020R:R:P186 R:R:P187 37.17241.95YesYes187
1021R:R:F428 R:R:V441 17.583313.11YesYes186
1022R:R:N383 R:R:V441 17.5767.39YesYes086
1023R:R:L399 R:R:M410 1004.24NoYes132
1024S:S:P161 S:S:Y419 54.92982.78YesYes195
1025S:S:A384 S:S:I140 15.69351.62NoYes087
1026S:S:G142 S:S:S148 18.23781.86YesYes157
1027S:S:F331 S:S:Q60 65.353718.74YesYes167
1028S:S:F327 S:S:F331 65.42565.36YesYes186
1029S:S:I72 S:S:Y386 18.29159.67YesYes196
1030R:R:R243 R:R:R271 11.836319.19YesYes125
1031S:S:L62 S:S:W344 18.32372.28YesYes154
1032S:S:F38 S:S:I88 20.96772.51YesYes187
1033S:S:F38 S:S:G36 13.06563.01YesYes188
1034S:S:L37 S:S:Q101 32.60882.66YesYes165
1035S:S:D295 S:S:K377 1002.77YesYes183
1036S:S:W297 S:S:Y468 62.71858.68YesYes164
1037S:S:P187 S:S:R183 1005.76YesYes179
1038S:S:P186 S:S:V185 91.2413.53YesYes187
1039S:S:D295 S:S:Y453 1003.45YesYes188
1040S:S:I485 S:S:V471 13.05129.22YesYes177
1041S:S:A236 S:S:Y206 1008.01YesYes189
1042S:S:F357 S:S:W349 19.6025.01YesYes138
1043S:S:L367 S:S:W349 57.51024.56NoYes168
1044R:R:G35 R:R:V139 52.10723.68YesYes197
1045R:R:I149 R:R:K171 26.32458.72YesYes153
1046R:R:F422 R:R:F443 49.812316.08YesYes148
1047R:R:R177 R:R:Y178 10018.52YesYes156
1048R:R:K175 R:R:Y419 85.62513.58NoYes065
1049R:R:F443 R:R:T184 84.92483.89YesYes089
1050R:R:L399 R:R:R417 1006.07NoNo136
1051S:S:A86 S:S:I88 10.50923.25YesYes177
1052S:S:G142 S:S:L37 15.64785.13YesYes156
1053S:S:R433 S:S:Y322 13.1187.2YesYes133
1054R:R:A387 R:R:F443 11.72522.77YesYes188
1055S:S:W474 S:S:Y453 1002.89YesYes168
1056S:S:C234 S:S:Y206 1004.03NoYes099
1057R:R:L172 R:R:S167 11.73083YesNo178
1058R:R:D448 R:R:P187 31.25669.66YesYes177
1059S:S:P39 S:S:R61 20.9032.88YesYes154
1060S:S:K43 S:S:R271 1004.95YesYes135
1061S:S:S93 S:S:Y144 35.126611.45NoYes113
1062R:R:F380 R:R:L319 1008.53YesYes164
1063R:R:Q191 R:R:Y453 10018.04YesYes188
1064R:R:I317 R:R:M195 1004.37YesYes167
1065R:R:F202 R:R:W204 11.723915.03YesYes189
1066R:R:I233 R:R:R231 10.82592.51YesYes164
1067S:S:A384 S:S:T184 23.46011.68NoYes089
1068S:S:F432 S:S:P431 32.5675.78YesYes147
1069S:S:P431 S:S:V382 13.02863.53YesYes178
1070S:S:D448 S:S:G447 15.63311.68YesYes177
1071S:S:I140 S:S:V385 10.46776.14YesYes179
1072S:S:A389 S:S:I72 10.42713.25NoYes199
1073R:R:D90 R:R:H41 18.543211.35YesYes198
1074R:R:V265 R:R:W204 34.16257.36YesYes189
1075R:R:F250 R:R:V241 11.70743.93YesYes136
1076S:S:K377 S:S:R61 1004.95YesYes134
1077S:S:E375 S:S:I378 1004.1YesYes157
1078S:S:A166 S:S:K377 11.71654.82YesYes153
1079S:S:F432 S:S:R71 13.01357.48YesYes147
1080R:R:S145 R:R:Y216 41.8695.09NoYes187
1081R:R:D188 R:R:Q191 23.80593.92YesYes188
1082R:R:T168 R:R:Y216 26.354.99YesYes177
1083S:S:I315 S:S:W204 16.92172.35YesYes159
1084S:S:D274 S:S:E273 31.22922.6YesNo141
1085R:R:A287 R:R:V254 11.71291.7YesYes145
1086R:R:P187 R:R:S173 11.7113.56YesYes178
1087S:S:A311 S:S:Y458 13.01332.67YesYes165
1088S:S:E197 S:S:L478 11.06442.65YesYes166
1089S:S:L319 S:S:Y453 1007.03YesYes148
1090S:S:L258 S:S:V254 23.42292.98NoYes135
1091S:S:A287 S:S:V254 23.42291.7YesYes145
1092S:S:F250 S:S:V241 10.40816.55YesYes136
1093S:S:P514 S:S:Q513 20.47399.47YesYes1955
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F38 S:S:R61 2.14 1 Yes Yes 8 4 2 1
S:S:F38 S:S:Y165 16.5 1 Yes Yes 8 8 2 2
S:S:F38 S:S:V381 3.93 1 Yes Yes 8 7 2 2
S:S:P39 S:S:R61 2.88 1 Yes Yes 5 4 2 1
S:S:P39 S:S:S93 1.78 1 Yes No 5 1 2 2
S:S:P39 S:S:S143 7.13 1 Yes Yes 5 4 2 1
S:S:P39 S:S:Y144 5.56 1 Yes Yes 5 3 2 1
S:S:K43 S:S:S93 3.06 1 Yes No 3 1 2 2
S:S:K43 S:S:R243 8.66 1 Yes Yes 3 2 2 2
S:S:K43 S:S:R271 4.95 1 Yes Yes 3 5 2 1
S:S:R57 S:S:R61 8.53 1 Yes Yes 4 4 1 1
S:S:R57 S:S:S272 3.95 1 Yes No 4 2 1 2
S:S:G296 S:S:R57 3 0 No Yes 5 4 2 1
S:S:L300 S:S:R57 12.15 1 Yes Yes 5 4 2 1
S:S:E375 S:S:R57 6.98 1 Yes Yes 5 4 2 1
M:M:?901 S:S:R57 18.75 1 Yes Yes 0 4 0 1
S:S:R61 S:S:S143 10.54 1 Yes Yes 4 4 1 1
S:S:R61 S:S:Y165 7.2 1 Yes Yes 4 8 1 2
S:S:A166 S:S:R61 2.77 1 Yes Yes 5 4 1 1
S:S:E375 S:S:R61 17.45 1 Yes Yes 5 4 2 1
S:S:K377 S:S:R61 4.95 1 Yes Yes 3 4 1 1
S:S:I378 S:S:R61 2.51 1 Yes Yes 7 4 2 1
S:S:R61 S:S:V381 3.92 1 Yes Yes 4 7 1 2
M:M:?901 S:S:R61 7.67 1 Yes Yes 0 4 0 1
S:S:S93 S:S:Y144 11.45 1 No Yes 1 3 2 1
S:S:S143 S:S:Y165 7.63 1 Yes Yes 4 8 1 2
S:S:A166 S:S:S143 3.42 1 Yes Yes 5 4 1 1
M:M:?901 S:S:S143 4.21 1 Yes Yes 0 4 0 1
S:S:R271 S:S:Y144 19.55 1 Yes Yes 5 3 1 1
S:S:E273 S:S:Y144 8.98 1 No Yes 1 3 2 1
M:M:?901 S:S:Y144 5.76 1 Yes Yes 0 3 0 1
S:S:S145 S:S:S167 1.63 1 Yes Yes 8 8 1 2
S:S:S145 S:S:S169 4.89 1 Yes No 8 7 1 2
S:S:S145 S:S:Y216 5.09 1 Yes Yes 8 7 1 1
M:M:?901 S:S:S145 4.21 1 Yes Yes 0 8 0 1
S:S:D146 S:S:R243 5.96 1 Yes Yes 5 2 2 2
S:S:D146 S:S:R271 3.57 1 Yes Yes 5 5 2 1
S:S:A166 S:S:Y165 2.67 1 Yes Yes 5 8 1 2
S:S:V381 S:S:Y165 10.09 1 Yes Yes 7 8 2 2
S:S:A166 S:S:K377 4.82 1 Yes Yes 5 3 1 1
M:M:?901 S:S:A166 5.53 1 Yes Yes 0 5 0 1
S:S:T168 S:S:V185 4.76 1 Yes Yes 7 7 1 2
S:S:D188 S:S:T168 4.34 1 Yes Yes 8 7 2 1
S:S:T168 S:S:Y216 4.99 1 Yes Yes 7 7 1 1
S:S:D295 S:S:T168 4.34 1 Yes Yes 8 7 2 1
M:M:?901 S:S:T168 5.17 1 Yes Yes 0 7 0 1
S:S:D188 S:S:S169 2.94 1 Yes No 8 7 2 2
S:S:F380 S:S:V185 7.87 1 Yes Yes 6 7 2 2
S:S:D188 S:S:Y216 9.2 1 Yes Yes 8 7 2 1
S:S:R271 S:S:S212 3.95 1 Yes Yes 5 6 1 2
S:S:D274 S:S:S212 5.89 1 Yes Yes 4 6 2 2
S:S:G217 S:S:Y216 4.35 0 No Yes 8 7 2 1
S:S:S294 S:S:Y216 6.36 0 No Yes 8 7 2 1
M:M:?901 S:S:Y216 26.32 1 Yes Yes 0 7 0 1
S:S:R243 S:S:R271 10.66 1 Yes Yes 2 5 2 1
S:S:E273 S:S:R271 11.63 1 No Yes 1 5 2 1
S:S:D274 S:S:R271 4.76 1 Yes Yes 4 5 2 1
M:M:?901 S:S:R271 2.56 1 Yes Yes 0 5 0 1
S:S:L300 S:S:S272 3 1 Yes No 5 2 2 2
S:S:D274 S:S:E273 2.6 1 Yes No 4 1 2 2
S:S:D295 S:S:K377 2.77 1 Yes Yes 8 3 2 1
S:S:E375 S:S:K377 4.05 1 Yes Yes 5 3 2 1
S:S:E375 S:S:I378 4.1 1 Yes Yes 5 7 2 2
S:S:F380 S:S:K377 2.48 1 Yes Yes 6 3 2 1
M:M:?901 S:S:K377 9.89 1 Yes Yes 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F38 R:R:P39 2.89 1 Yes Yes 8 5 2 2
R:R:F38 R:R:R61 2.14 1 Yes Yes 8 4 2 1
R:R:F38 R:R:Y165 22.69 1 Yes Yes 8 8 2 2
R:R:P39 R:R:S93 1.78 1 Yes No 5 1 2 2
R:R:P39 R:R:S143 7.13 1 Yes Yes 5 4 2 1
R:R:P39 R:R:Y144 6.95 1 Yes Yes 5 3 2 1
R:R:K43 R:R:R243 7.43 1 Yes Yes 3 2 2 2
R:R:K43 R:R:R271 2.48 1 Yes Yes 3 5 2 1
R:R:E273 R:R:K43 4.05 1 Yes Yes 1 3 2 2
R:R:R57 R:R:R61 13.86 1 Yes Yes 4 4 1 1
R:R:R57 R:R:S272 9.22 1 Yes No 4 2 1 2
R:R:G296 R:R:R57 3 1 No Yes 5 4 1 1
R:R:L300 R:R:R57 4.86 1 Yes Yes 5 4 2 1
R:R:E375 R:R:R57 11.63 1 No Yes 5 4 2 1
L:L:?901 R:R:R57 17.9 1 Yes Yes 0 4 0 1
R:R:R61 R:R:S143 5.27 1 Yes Yes 4 4 1 1
R:R:R61 R:R:Y165 3.09 1 Yes Yes 4 8 1 2
R:R:A166 R:R:R61 4.15 1 Yes Yes 5 4 1 1
R:R:E375 R:R:R61 8.14 1 No Yes 5 4 2 1
R:R:K377 R:R:R61 11.14 1 Yes Yes 3 4 1 1
R:R:I378 R:R:R61 2.51 1 Yes Yes 7 4 2 1
R:R:R61 R:R:V381 3.92 1 Yes Yes 4 7 1 2
L:L:?901 R:R:R61 8.52 1 Yes Yes 0 4 0 1
R:R:S93 R:R:Y144 8.9 1 No Yes 1 3 2 1
R:R:R271 R:R:S93 2.64 1 Yes No 5 1 1 2
R:R:S143 R:R:Y165 6.36 1 Yes Yes 4 8 1 2
R:R:A166 R:R:S143 3.42 1 Yes Yes 5 4 1 1
L:L:?901 R:R:S143 2.11 1 Yes Yes 0 4 0 1
R:R:V147 R:R:Y144 3.79 1 Yes Yes 4 3 2 1
R:R:R271 R:R:Y144 22.64 1 Yes Yes 5 3 1 1
R:R:E273 R:R:Y144 3.37 1 Yes Yes 1 3 2 1
L:L:?901 R:R:Y144 4.11 1 Yes Yes 0 3 0 1
R:R:S145 R:R:S169 6.52 1 No Yes 8 7 1 2
R:R:S145 R:R:Y216 5.09 1 No Yes 8 7 1 1
L:L:?901 R:R:S145 4.21 1 Yes No 0 8 0 1
R:R:D146 R:R:V147 2.92 1 Yes Yes 5 4 2 2
R:R:D146 R:R:R243 13.1 1 Yes Yes 5 2 2 2
R:R:D146 R:R:R271 3.57 1 Yes Yes 5 5 2 1
R:R:A166 R:R:Y165 2.67 1 Yes Yes 5 8 1 2
R:R:V381 R:R:Y165 8.83 1 Yes Yes 7 8 2 2
R:R:A166 R:R:K377 3.21 1 Yes Yes 5 3 1 1
L:L:?901 R:R:A166 5.53 1 Yes Yes 0 5 0 1
R:R:T168 R:R:V185 4.76 1 Yes Yes 7 7 1 2
R:R:D188 R:R:T168 5.78 1 Yes Yes 8 7 2 1
R:R:T168 R:R:Y216 4.99 1 Yes Yes 7 7 1 1
R:R:D295 R:R:T168 4.34 1 Yes Yes 8 7 1 1
L:L:?901 R:R:T168 5.17 1 Yes Yes 0 7 0 1
R:R:K377 R:R:V185 3.04 1 Yes Yes 3 7 1 2
R:R:F380 R:R:V185 11.8 1 Yes Yes 6 7 2 2
R:R:D188 R:R:Q191 3.92 1 Yes Yes 8 8 2 2
R:R:D188 R:R:Y216 8.05 1 Yes Yes 8 7 2 1
R:R:Q191 R:R:Y216 3.38 1 Yes Yes 8 7 2 1
R:R:D295 R:R:Q191 13.05 1 Yes Yes 8 8 1 2
R:R:Q191 R:R:Y453 18.04 1 Yes Yes 8 8 2 2
R:R:R271 R:R:S212 3.95 1 Yes Yes 5 6 1 2
R:R:D274 R:R:S212 5.89 1 Yes Yes 4 6 2 2
R:R:F269 R:R:Y216 3.09 1 Yes Yes 7 7 2 1
R:R:S294 R:R:Y216 8.9 1 No Yes 8 7 2 1
R:R:D295 R:R:Y216 3.45 1 Yes Yes 8 7 1 1
L:L:?901 R:R:Y216 24.68 1 Yes Yes 0 7 0 1
R:R:R243 R:R:R271 19.19 1 Yes Yes 2 5 2 1
R:R:F269 R:R:S294 5.28 1 Yes No 7 8 2 2
R:R:E273 R:R:R271 13.96 1 Yes Yes 1 5 2 1
R:R:D274 R:R:R271 4.76 1 Yes Yes 4 5 2 1
L:L:?901 R:R:R271 2.56 1 Yes Yes 0 5 0 1
R:R:L300 R:R:S272 3 1 Yes No 5 2 2 2
R:R:D274 R:R:E273 2.6 1 Yes Yes 4 1 2 2
R:R:G296 R:R:S294 1.86 1 No No 5 8 1 2
R:R:D295 R:R:E318 3.9 1 Yes Yes 8 6 1 2
R:R:D295 R:R:L319 5.43 1 Yes Yes 8 4 1 2
R:R:D295 R:R:Y453 4.6 1 Yes Yes 8 8 1 2
L:L:?901 R:R:D295 2.86 1 Yes Yes 0 8 0 1
L:L:?901 R:R:G296 3.6 1 Yes No 0 5 0 1
R:R:E318 R:R:L319 5.3 1 Yes Yes 6 4 2 2
R:R:E318 R:R:K377 4.05 1 Yes Yes 6 3 2 1
R:R:K377 R:R:L319 4.23 1 Yes Yes 3 4 1 2
R:R:F380 R:R:L319 8.53 1 Yes Yes 6 4 2 2
R:R:L319 R:R:Y453 10.55 1 Yes Yes 4 8 2 2
R:R:F380 R:R:K377 2.48 1 Yes Yes 6 3 2 1
L:L:?901 R:R:K377 6.93 1 Yes Yes 0 3 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
100.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Single7FIIhCG7FII-LH-hCG-6fuf
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
100.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
100.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
100.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
100.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensusgs_proteinOrthosteric Ligandgs_gphr
100.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
100.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
100.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
33.33Single8HS2Fab0468HS2-GPR20-Fab046
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single6LI0GTPL98046LI0-GPR52-GTPL9804
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
14.29Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50Consensusgo_proteinOrthosteric Ligandgo_chemokine
12.50Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
10.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
10.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00Consensusgnrh_offOrthosteric Ligandgnrh1_off
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.00Consensuss1p_offOrthosteric Ligands1p1_off
9.09Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
9.09Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
9.09Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
8.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
8.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.33Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
7.69Consensuslpa_offOrthosteric Ligandlpa1_off
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
7.14Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
7.14Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
7.14Consensuschemokine_offOrthosteric Ligandcxcr_off
7.14Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.14Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.14Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
7.14Consensusdp_offOrthosteric Liganddp2_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
7.14Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
7.14Consensusnts_onOrthosteric Ligandnts1_on
7.14Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
7.14Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
6.67Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
6.67Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
6.67Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
6.25Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
6.25Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25Consensuslpl_offOrthosteric Ligands1p_off lpa_off
6.25Consensuslpl_onOrthosteric Ligands1p_on lpa_on
6.25Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
6.25Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.88Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.88Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
5.56Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.56Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
5.26Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
5.26Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
5.26Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
5.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
5.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.76Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.76Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.55Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.35Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35Consensusgo_class-b1Orthosteric Ligandgo_crf
4.35Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon
4.17Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
4.17Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.17Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.85Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.85Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.57Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
3.23Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
3.03Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F623 R:R:M619 9.95 6 No Yes 8 7 2 2
R:R:L639 R:R:M619 2.83 6 Yes Yes 8 7 1 2
R:R:F623 R:R:L639 2.44 6 No Yes 8 8 2 1
R:R:F623 R:R:M794 4.98 6 No No 8 9 2 2
R:R:G640 R:R:L639 3.42 0 No Yes 6 8 2 1
R:R:F643 R:R:L639 4.87 6 Yes Yes 8 8 1 1
R:R:L639 W:W:?902 2.17 6 Yes Yes 8 0 1 0
R:R:F643 R:R:Y647 7.22 6 Yes Yes 8 6 1 1
R:R:F643 R:R:N735 4.83 6 Yes No 8 7 1 1
R:R:F643 R:R:W773 7.02 6 Yes Yes 8 9 1 1
R:R:F643 W:W:?902 16.2 6 Yes Yes 8 0 1 0
R:R:N735 R:R:Y647 9.3 6 No Yes 7 6 1 1
R:R:L738 R:R:Y647 2.34 0 No Yes 9 6 2 1
R:R:I739 R:R:Y647 7.25 6 No Yes 8 6 2 1
R:R:W773 R:R:Y647 20.26 6 Yes Yes 9 6 1 1
R:R:Y647 W:W:?902 9.17 6 Yes Yes 6 0 1 0
R:R:M728 R:R:N722 2.8 0 No No 7 6 1 2
R:R:H723 R:R:R724 4.51 0 No No 5 8 2 1
R:R:R724 R:R:S784 5.27 6 No No 8 6 1 1
R:R:R724 W:W:?902 1.9 6 No Yes 8 0 1 0
R:R:M728 W:W:?902 12.17 0 No Yes 7 0 1 0
R:R:L732 R:R:L777 4.15 6 No No 8 7 1 1
R:R:L732 W:W:?902 14.08 6 No Yes 8 0 1 0
R:R:N735 W:W:?902 12.89 6 No Yes 7 0 1 0
R:R:I739 R:R:W773 2.35 6 No Yes 8 9 2 1
R:R:T769 R:R:W773 4.85 0 Yes Yes 8 9 2 1
R:R:S801 R:R:W773 8.65 0 No Yes 9 9 2 1
R:R:W773 W:W:?902 9.8 6 Yes Yes 9 0 1 0
R:R:L777 R:R:P778 3.28 6 No No 7 8 1 2
R:R:L777 W:W:?902 3.25 6 No Yes 7 0 1 0
R:R:F780 R:R:Q790 19.91 0 No Yes 8 7 1 2
R:R:F780 R:R:M794 7.46 0 No No 8 9 1 2
R:R:F780 W:W:?902 15.25 0 No Yes 8 0 1 0
R:R:Q790 R:R:S784 8.66 0 Yes No 7 6 2 1
R:R:S784 W:W:?902 3.52 6 No Yes 6 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
60.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
50.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
47.06Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
47.06Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
46.67Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
46.67Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
46.15Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
45.45Consensusclass-c_onOther Ligandgabab_on mglu_on
44.44Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
44.44Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
42.86Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
42.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
42.86Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
42.86Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
42.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
42.11Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.11Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
41.18Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
41.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
41.18Single6J21Aprepitant6J21-NK1-Aprepitant
41.18Single7EPENAM5637EPE-mGlu-NAM563
41.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
41.18Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
41.18Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
41.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
41.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
41.18Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Consensusa2_onOrthosteric Liganda2a_on a2b_on
40.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
40.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
38.89Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
38.89Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
38.10Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
38.10Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
37.50Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
37.50Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
37.50Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
37.50Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
37.50Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
37.50Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
37.50Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Single8CU6LJ-45178CU6-A2A-LJ-4517
37.50Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
37.50Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
37.50Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
37.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
37.50Single8X63Mepyramine8X63-H1-Mepyramine
37.50Single8X64Desloratadine8X64-H1-Desloratadine
37.50Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
37.50Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
37.50Consensusadenosine_onOrthosteric Liganda1_on a2_on
37.50Consensusnucleotide_onOrthosteric Ligandadenosine_on
37.50Consensustachykinin_offOrthosteric Ligandnk1_off
36.84Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
36.84Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
36.84Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
36.84Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
36.84Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
35.71Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
35.71Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
35.71Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
35.71Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
35.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
35.29Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
35.29Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
35.29Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.29Single6PS6Timolol6PS6-β2-Timolol
35.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
35.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8EA0Iperoxo8EA0-M3-Iperoxo
35.29Single8QOTNanobody E8QOT-μ-Nanobody E
35.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
35.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
34.78Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single2YDVNECA2YDV-A2A-NECA
33.33Single4UHRCGS216804UHR-A2A-CGS21680
33.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
33.33Single5G53NECA5G53-A2A-NECA-Gs
33.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
33.33Single6E59L-7607356E59-NK1-L-760735
33.33Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
33.33Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
33.33Single6J20Aprepitant6J20-NK1-Aprepitant
33.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
33.33Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
33.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
33.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
33.33Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
33.33Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
33.33Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
33.33Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
33.33Consensushistamine_offOrthosteric Ligandh1_off
33.33Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
33.33Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
33.33Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
33.33Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
33.33Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
31.82Single3QAKUK-4320973QAK-A2A-UK-432097
31.82Single6HLOAprepitant6HLO-NK1-Aprepitant
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
31.58Single6HLPNetupitant6HLP-NK1-Netupitant
31.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
31.58Single7DFPSpiperone7DFP-D2-Spiperone
31.58Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
31.58Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.58Single7YITNalfurafine7YIT-κ-Nalfurafine
31.58Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.58Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
31.58Consensusclass-b2_onOrthosteric Ligandadgrg_on
31.58Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
31.25Single2YDOAdenosine2YDO-A2A-Adenosine
31.25Single3RZECidoxepin3RZE-H1-Cidoxepin
31.25Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
31.25Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
31.25Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
31.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.25Single5JTBZM2413855JTB-A2A-ZM241385
31.25Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
31.25Single5UVIZM2413855UVI-A2A-ZM241385
31.25Single6AQFZM2413856AQF-A2A-ZM241385
31.25Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
31.25Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Single6TPKRetosiban6TPK-OT-Retosiban
31.25Single6TPNHTL66416TPN-OX2-HTL6641
31.25Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.25Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
31.25Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
31.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
31.25Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
31.25Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
31.25Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
31.25Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
31.25Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
31.25Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
31.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.25Consensussensory_offOrthosteric Ligandopsin_off
31.25Consensusvasopressin-ot_offOrthosteric Ligandot_off
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
30.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
30.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
30.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
30.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
30.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
30.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
30.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
30.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single3EMLZM2413853EML-A2A-ZM241385
29.41Single3NY8ICI 118-5513NY8-β2-ICI 118-551
29.41Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
29.41Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
29.41Single4DAJTiotropium4DAJ-M3-Tiotropium
29.41Single4EIYZM2413854EIY-A2A-ZM241385-Na
29.41Single4EJ4Naltrindole4EJ4-δ-Naltrindole
29.41Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
29.41Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
29.41Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
29.41Single5K2AZM2413855K2A-A2A-ZM241385-Na
29.41Single5OLGZM2413855OLG-A2A-ZM241385-Na
29.41Single5VRAZM2413855VRA-A2A-ZM241385-Na
29.41Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
29.41Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
29.41Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
29.41Single6S0LZM2413856S0L-A2A-ZM241385
29.41Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
29.41Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
29.41Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
29.41Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
29.41Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.41Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
29.41Single8JJOAlprenolol8JJO-β2-Alprenolol
29.41Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
29.41Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
29.41Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
29.41Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
29.41Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
29.41Consensustar_onOrthosteric Ligandta1_on
28.57Single4UG2CGS216804UG2-A2A-CGS21680
28.57Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
28.57Single6PT3DPI-2876PT3-δ-DPI-287
28.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
28.57Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
28.57Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
28.57Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
28.57Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
28.57Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8X5YAstemizole8X5Y-H1-Astemizole
28.57Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_class-b2Orthosteric Ligandgs_adgr
28.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
27.78Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
27.78Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
27.78Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
27.78Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5NM2ZM2413855NM2-A2A-ZM241385-Na
27.78Single5TVNLSD5TVN-5-HT2B-LSD
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6LPLZM2413856LPL-A2A-ZM241385-Na
27.78Single6LUQHaloperidol6LUQ-D2-Haloperidol
27.78Single6S0QZM2413856S0Q-A2A-ZM241385
27.78Single6WQAZM2413856WQA-A2A-ZM241385-Na
27.78Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
27.78Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.78Single7RM5ZM2413857RM5-A2A-ZM241385-Na
27.78Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
27.78Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
27.78Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
27.78Single7WC6LSD7WC6-5-HT2A-LSD
27.78Single8FYNZM2413858FYN-A2A-ZM241385-Na
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.78Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
27.78Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
27.78Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
27.78Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
27.78Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
27.78Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
27.78Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
27.78Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
27.78Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
27.78Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.78Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.78Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
27.78Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
26.92Consensusclass-d_onOrthosteric Ligandste2_on
26.92Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
26.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
26.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
26.67Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
26.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
26.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
26.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
26.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
26.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
26.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
26.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
26.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
26.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
26.32Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
26.32Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
26.32Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
26.32Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
26.32Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
26.32Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
26.32Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
26.32Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
26.32Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.32Single6TQ7SB-3348676TQ7-OX1-SB-334867
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single6WGTLSD6WGT-5-HT2A-LSD
26.32Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
26.32Single7P2L4YI7P2L-mGlu5-4YI
26.32Single7PX4PSB-21137PX4-A2A-PSB-2113
26.32Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
26.32Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
26.32Single7W41PD1762527W41-BB2-PD176252
26.32Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
26.32Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
26.32Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
26.32Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
26.32Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
26.32Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
26.32Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
26.32Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
26.32Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
26.32Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
26.32Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
26.32Consensus5ht5_offOrthosteric Ligand5ht5a_off
26.32Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.32Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
26.32Consensusbombesin_offOrthosteric Ligandbb2_off
26.32Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
26.32Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
26.32Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.32Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.32Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
26.32Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
26.32Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
26.32Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
26.32Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
26.09Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.09Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.93Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
25.93Consensusgi_class-dOrthosteric Ligandgi_ste
25.93Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
25.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
25.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
25.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
25.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
25.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
25.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
25.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
25.00Single4AMIBucindolol4AMI-β1-Bucindolol
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single5CXVTiotropium5CXV-M1-Tiotropium
25.00Single5DHHSB-6121115DHH-NOP-SB-612111
25.00Single5K2DZM2413855K2D-A2A-ZM241385
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
25.00Single6CM4Risperidone6CM4-D2-Risperidone
25.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
25.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
25.00Single6PT2KGCHM076PT2-δ-KGCHM07
25.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
25.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
25.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
25.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
25.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
25.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
25.00Single8JWZAB9288JWZ-A2A-AB928-Na
25.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
25.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
25.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
25.00Consensusgi_class-fOther Ligandgi_frizzled
25.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
25.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
25.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
25.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
25.00Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
25.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
24.14Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
24.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.81Single5CGDHTL142425CGD-mGlu5-HTL14242
23.81Single7EZCUKA7EZC-A2A-UKA
23.81Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
23.81Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
23.81Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
23.81Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
23.81Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusendothelin_offOrthosteric Ligandetb_off
23.81Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
23.81Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
23.53Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
23.53Single5IU4ZM2413855IU4-A2A-ZM241385-Na
23.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
23.53Single5K2BZM2413855K2B-A2A-ZM241385-Na
23.53Single5K2CZM2413855K2C-A2A-ZM241385-Na
23.53Single5NLXZM2413855NLX-A2A-ZM241385-Na
23.53Single5NM4ZM2413855NM4-A2A-ZM241385-Na
23.53Single6A94Zotepine6A94-5-HT2A-Zotepine
23.53Single6MH8ZM2413856MH8-A2A-ZM241385
23.53Single6PS4ICI 118-5516PS4-β2-ICI 118-551
23.53Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
23.53Single6TPGEMPA6TPG-OX2-EMPA
23.53Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
23.53Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
23.53Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
23.53Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7VV6C48/807VV6-MRGPRX2-C48/80
23.53Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
23.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
23.53Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
23.53Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8GGKEpinephrine8GGK-β2-Epinephrine
23.53Single8GGLEpinephrine8GGL-β2-Epinephrine
23.53Single8GGMEpinephrine8GGM-β2-Epinephrine
23.53Single8GGPEpinephrine8GGP-β2-Epinephrine
23.53Single8GGQEpinephrine8GGQ-β2-Epinephrine
23.53Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
23.53Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
23.53Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
23.53Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
23.53Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht5_onOrthosteric Ligand5ht5a_on
23.53Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
23.53Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
23.53Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
23.53Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
23.53Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
23.08Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
23.08Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
22.73Single5WF6UK-4320975WF6-A2A-UK-432097
22.73Single5ZTYAM102575ZTY-CB2-AM10257
22.73Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
22.73Consensusclass-d_offOrthosteric Ligandste2_off
22.73Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
22.73Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
22.22Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
22.22Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
22.22Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
22.22Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
22.22Single4MQSIperoxo4MQS-M2-Iperoxo
22.22Single4U14Tiotropium4U14-M3-Tiotropium
22.22Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
22.22Single5DSGTiotropium5DSG-M4-Tiotropium
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
22.22Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
22.22Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
22.22Single6LPJZM2413856LPJ-A2A-ZM241385-Na
22.22Single6LPKZM2413856LPK-A2A-ZM241385-Na
22.22Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
22.22Single6PS1Timolol6PS1-β2-Timolol
22.22Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
22.22Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
22.22Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
22.22Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
22.22Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
22.22Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
22.22Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7WC7Lisuride7WC7-5-HT2A-Lisuride
22.22Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
22.22Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8GGJEpinephrine8GGJ-β2-Epinephrine
22.22Single8GGNEpinephrine8GGN-β2-Epinephrine
22.22Single8GGOEpinephrine8GGO-β2-Epinephrine
22.22Single8GGUEpinephrine8GGU-β2-Epinephrine
22.22Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
22.22Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
22.22Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
22.22Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
22.22Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
22.22Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
22.22Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
22.22Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
22.22Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
22.22Consensushistamine_onOrthosteric Ligandh1_on h4_on
22.22Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
22.22Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.74Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
21.43Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
21.43Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.43Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
21.43Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
21.43Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
21.43Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
21.43Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgo_class-b1Orthosteric Ligandgo_crf
21.43Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.43Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.05Single5C1MBU725C1M-μ-BU72
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
21.05Single5WQCEMPA5WQC-OX2-EMPA
21.05Single5XPRBosentan5XPR-ETB-Bosentan
21.05Single6E67BI1671076E67-β2-BI167107-Gs (fused)
21.05Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
21.05Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
21.05Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
21.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
21.05Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
21.05Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
21.05Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
21.05Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
21.05Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
21.05Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7XKAEpinephrine7XKA-β2-Epinephrine
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
21.05Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
21.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.05Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
21.05Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.05Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
21.05Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
21.05Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
21.05Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
21.05Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
21.05Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
21.05Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.83Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
20.83Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
20.83Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
20.83Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.69Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.69Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
20.00Single3P0GBI1671073P0G-β2-BI167107
20.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
20.00Single4U15Tiotropium4U15-M3-Tiotropium
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5X93K-87945X93-ETB-K-8794
20.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
20.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
20.00Single6OL9Tiotropium6OL9-M5-Tiotropium
20.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
20.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
20.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
20.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
20.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
20.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
20.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
20.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
20.00Single8E0GBU728E0G-μ-BU72
20.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
20.00Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
20.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
20.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
20.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
20.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
20.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
20.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
20.00Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
20.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
19.35Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
19.35Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
19.23Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
19.05Single4LDEBI1671074LDE-β2-BI167107
19.05Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
19.05Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
19.05Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
19.05Single6MXTSalmeterol6MXT-β2-Salmeterol
19.05Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
19.05Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
19.05Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
19.05Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
19.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
19.05Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
19.05Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
19.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
19.05Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8JJ8Formoterol8JJ8-β2-Formoterol
19.05Single8JJLOlodaterol8JJL-β2-Olodaterol
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
19.05Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
19.05Single8WU1KCA8WU1-CB1-KCA-Arrestin1
19.05Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
19.05Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
19.05Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
19.05Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
19.05Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
18.75Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
18.75Single3PBLEticlopride3PBL-D3-Eticlopride
18.75Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6HLLCP999946HLL-NK1-CP99994
18.75Single6TP4ACT-4622066TP4-OX1-ACT-462206
18.75Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
18.75Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
18.75Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single7SRQLSD7SRQ-5-HT2B-LSD
18.75Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.75Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.75Single8GGSEpinephrine8GGS-β2-Epinephrine
18.75Single8GH1Epinephrine8GH1-β2-Epinephrine
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
18.75Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
18.75Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.75Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
18.52Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
18.52Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.52Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
18.52Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
18.42Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
18.18Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
18.18Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.18Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
18.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
18.18Single6H7LDobutamine6H7L-β1-Dobutamine
18.18Single6IBLArformoterol6IBL-β1-Arformoterol
18.18Single6K1QIRL25006K1Q-ETB-IRL2500
18.18Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
18.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
18.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
18.18Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
18.18Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
18.18Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
18.18Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
18.18Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
18.18Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
18.18Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off
18.18Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
18.18Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.18Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
18.18Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
18.18Consensussteroid_onOrthosteric Ligandbileacid_on
17.86Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.86Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.86Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
17.86Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.86Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
17.65Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
17.65Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
17.65Single3PWHZM2413853PWH-A2A-ZM241385
17.65Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.65Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.65Single5ZKQABT-4915ZKQ-PAF-ABT-491
17.65Single6AKXA4R6AKX-CCR5-A4R
17.65Single6ME2Ramelteon6ME2-MT1-Ramelteon
17.65Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single6TODEMPA6TOD-OX1-EMPA-Na
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
17.65Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
17.65Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
17.65Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
17.65Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
17.65Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
17.65Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
17.65Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8GGVEpinephrine8GGV-β2-Epinephrine
17.65Single8GGXEpinephrine8GGX-β2-Epinephrine
17.65Single8GH0Epinephrine8GH0-β2-Epinephrine
17.65Single8GNGIstradefylline8GNG-A2A-Istradefylline
17.65Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
17.65Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
17.65Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
17.65Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
17.65Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
17.65Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusgt_class-aOrthosteric Ligandgt_opsin
17.65Consensusgt_opsinOrthosteric Ligandgt_sensory
17.65Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
17.65Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
17.65Consensusorexin_offOrthosteric Ligandox2_off ox1_off
17.65Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
17.39Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7SK9CCX6627SK9-ACKR3-CCX662
17.39Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
17.39Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
17.39Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
17.39Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
17.39Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
17.39Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
17.39Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
17.39Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
17.39Consensuslpl_offOrthosteric Ligands1p_off lpa_off
17.39Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.24Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
17.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
17.24Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.24Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single4IARErgotamine4IAR-5-HT1B-Ergotamine
16.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
16.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
16.67Single6IGLIRL16206IGL-ETB-IRL1620
16.67Single6IQLL7458706IQL-D4-L745870
16.67Single6LMLGlucagon6LML-Glucagon-Glucagon
16.67Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
16.67Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.67Single6VI4JDTic6VI4-κ-JDTic
16.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
16.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
16.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
16.67Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
16.67Single7F8XNN90567F8X-CCKA-NN9056
16.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single7T32ZM2413857T32-A2A-ZM241385
16.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
16.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
16.67Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
16.67Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
16.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.67Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
16.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
16.67Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8GGIEpinephrine8GGI-β2-Epinephrine
16.67Single8GGTEpinephrine8GGT-β2-Epinephrine
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
16.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
16.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
16.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
16.67Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
16.67Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.67Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
16.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
16.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
16.67Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
16.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
16.67Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
16.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
16.67Consensushca_onOrthosteric Ligandhca2_on hca3_on
16.67Consensushcar_onOrthosteric Ligandhca_on
16.67Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
16.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
16.67Consensussst_onOrthosteric Ligandsst2_on sst4_on
16.13Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
16.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
15.79Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
15.79Single2Y02Carmoterol2Y02-β1-Carmoterol
15.79Single2Y04Salbutamol2Y04-β1-Salbutamol
15.79Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
15.79Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
15.79Single5TGZAM65385TGZ-CB1-AM6538
15.79Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
15.79Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.79Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.79Single6FFHFenobam6FFH-mGlu5-Fenobam
15.79Single6H7MSalbutamol6H7M-β1-Salbutamol
15.79Single6IIVDaltroban6IIV-TP-Daltroban
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
15.79Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
15.79Single6TOTLemborexant6TOT-OX1-Lemborexant
15.79Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.79Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
15.79Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
15.79Single7UL4Alvimopan7UL4-μ-Alvimopan
15.79Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
15.79Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
15.79Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
15.79Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
15.79Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
15.79Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
15.79Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
15.79Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
15.79Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
15.79Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
15.79Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
15.79Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
15.79Consensuscck_offOrthosteric Ligandccka_off
15.79Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.79Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
15.79Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
15.79Consensusgi_hcarOrthosteric Ligandgi_hca
15.79Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
15.79Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.79Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
15.79Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.79Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
15.62Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.62Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
15.38Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
15.38Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
15.38Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
15.38Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
15.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.00Single5WIUNemonapride5WIU-D4-Nemonapride
15.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
15.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6TP6Filorexant6TP6-OX1-Filorexant
15.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
15.00Single7C4SS1P7C4S-S1P3-S1P
15.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
15.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
15.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
15.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
15.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
15.00Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
15.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
15.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
15.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
14.81Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.81Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
14.81Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
14.81Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
14.81Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.81Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
14.29Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
14.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
14.29Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single5V56TC1145V56-SMO-TC114
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single5XRAAM115425XRA-CB1-AM11542
14.29Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.29Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
14.29Single7B6WCyclazosin7B6W-α1b-Cyclazosin
14.29Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
14.29Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.29Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
14.29Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
14.29Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
14.29Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
14.29Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
14.29Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
14.29Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
14.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
14.29Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
14.29Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
14.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
14.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
14.29Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
14.29Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
14.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
14.29Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
14.29Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
14.29Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.29Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.29Consensuslpa_offOrthosteric Ligandlpa1_off
14.29Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.79Single6FJ3PTH6FJ3-PTH1-PTH
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
13.79Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.79Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.64Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
13.64Single6IIURamatroban6IIU-TP-Ramatroban
13.64Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
13.64Single6ZG4HTL00099366ZG4-M1-HTL0009936
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.64Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
13.64Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
13.64Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
13.64Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.64Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.64Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
13.64Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
13.64Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
13.64Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
13.64Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
13.64Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
13.64Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
13.64Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
13.64Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
13.64Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.64Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.64Consensusgs_steroidOrthosteric Ligandgs_bileacid
13.64Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.64Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
13.64Consensusnts_onOrthosteric Ligandnts1_on
13.64Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.64Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.33Single3RFMCaffeine3RFM-A2A-Caffeine
13.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
13.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
13.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
13.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
13.33Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.33Consensussensory_onOrthosteric Ligandopsin_on
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
13.04Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
13.04Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
13.04Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
13.04Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
13.04Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
13.04Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.04Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
13.04Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusorexin_onOrthosteric Ligandox2_on
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
12.90Single8IY6Endothelin-18IY6-ETB-Endothelin-1
12.90Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
12.90Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
12.50Single3OE6IT1t3OE6-CXCR4-IT1t
12.50Single5GLHEndothelin-15GLH-ETB-Endothelin-1
12.50Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
12.50Single6IGKEndothelin-36IGK-ETB-Endothelin-3
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single7XN9L-054,5227XN9-SST2-L-054,522
12.50Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
12.50Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
12.50Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.50Single8GGREpinephrine8GGR-β2-Epinephrine
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
12.50Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
12.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
12.50Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
12.50Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
12.50Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
12.50Consensuslpl_onOrthosteric Ligands1p_on lpa_on
12.50Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.50Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
12.50Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
12.50Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.12Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
12.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
12.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
12.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
12.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
12.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
12.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
12.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
12.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
12.00Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
12.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
12.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
12.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
11.76Single3OE9IT1t3OE9-CXCR4-IT1t
11.76Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.76Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
11.76Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
11.76Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
11.76Single8GGYEpinephrine8GGY-β2-Epinephrine
11.76Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.76Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
11.76Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
11.76Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.54Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
11.54Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
11.54Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
11.54Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.54Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
11.54Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
11.54Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
11.43Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.11Single3ODUIT1t3ODU-CXCR4-IT1t
11.11Single3OE0CVX153OE0-CXCR4-CVX15
11.11Single4K5YCP-3763954K5Y-CRF1-CP-376395
11.11Single4S0VSuvorexant4S0V-OX2-Suvorexant
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5WS3EMPA5WS3-OX2-EMPA
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6KUXRS-799486KUX-α2a-RS-79948
11.11Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6TPJSuvorexant6TPJ-OX2-Suvorexant
11.11Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.11Single6W25SHU91196W25-MC4-SHU9119-Ca
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
11.11Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
11.11Single7XRRLemborexant7XRR-OX2-Lemborexant
11.11Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single8GGWEpinephrine8GGW-β2-Epinephrine
11.11Single8IHKAcifran8IHK-HCA3-Acifran
11.11Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single8IWESpermidine8IWE-TAAR9-Spermidine
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
11.11Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
11.11Consensusangiotensin_onOrthosteric Ligandat1_on
11.11Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
11.11Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
11.11Consensusclass-f_offOrthosteric Ligandsmo_off
11.11Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.11Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.81Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71Single6JODAngiotensin II6JOD-AT2-Angiotensin II
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
10.71Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
10.71Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
10.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
10.71Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.71Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
10.71Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.53Single6DS0Ly2660976DS0-5-HT2B-Ly266097
10.53Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
10.53Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
10.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
10.53Single6V9SGTPL114036V9S-OX1-GTPL11403
10.53Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.53Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
10.53Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.53Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
10.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.53Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.53Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
10.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
10.53Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
10.53Consensuss1p_offOrthosteric Ligands1p1_off
10.34Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.34Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.34Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.34Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
10.34Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
10.34Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
10.34Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
10.34Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.34Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.26Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
10.00Single4Z9GCP-3763954Z9G-CRF1-CP-376395
10.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
10.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
10.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
10.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
10.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
10.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
10.00Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
10.00Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.00Single8GTIBMK-C2058GTI-CRF1-BMK-C205
10.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
10.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
10.00Single8K5DGSK2560738K5D-HCA2-GSK256073
10.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
10.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
10.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.00Consensusleuko_onOrthosteric Ligandblt_on
10.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
10.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.68Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.68Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
9.68Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.52Single2Y00Dobutamine2Y00-β1-Dobutamine
9.52Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
9.52Single4NTJAZD12834NTJ-P2Y12-AZD1283
9.52Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single6D26Fevipiprant6D26-DP2-Fevipiprant
9.52Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
9.52Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
9.52Single6Z4SSR486926Z4S-NTS1-SR48692
9.52Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.52Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
9.52Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.52Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.52Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8GTGBMK-I1528GTG-CRF1-BMK-I152
9.52Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
9.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
9.52Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.52Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
9.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.38Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
9.38Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.09Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.09Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.09Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
9.09Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.09Single5V57TC1145V57-SMO-TC114
9.09Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.09Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
9.09Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
9.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
9.09Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.09Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
9.09Consensuslpa_onOrthosteric Ligandlpa1_on
9.09Consensusrelaxin_onOrthosteric Ligandrxfp4_on
8.82Consensusglp_onOrthosteric Ligandglp1_on glp2_on
8.70Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.70Single4XESNeurotensin4XES-NTS1-Neurotensin
8.70Single5X33BIIL2605X33-BLT1-BIIL260
8.70Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
8.70Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.70Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.70Single7K15MKD0467K15-BLT1-MKD046-Na
8.70Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
8.70Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
8.70Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
8.70Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
8.70Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
8.70Consensusblt_offOrthosteric Ligandblt1_off
8.70Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
8.70Consensusdp_offOrthosteric Liganddp2_off
8.70Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.70Consensusnts_offOrthosteric Ligandnts1_off
8.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.33Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
8.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.33Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
8.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
8.33Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
8.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
8.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
8.00Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
8.00Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
8.00Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
7.69Single4XT1Fractalkine4XT1-US28-Fractalkine
7.69Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
7.69Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
7.50Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.41Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
7.41Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.41Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.41Consensussst_offOrthosteric Ligandsst2_off
7.32Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
7.14Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
7.14Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.14Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
7.14Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
7.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
7.14Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
7.14Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
7.14Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
6.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.90Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
6.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
6.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.67Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.45Single4XT3Fractalkine4XT3-US28-Fractalkine
6.45Single7SK3CXCL127SK3-ACKR3-CXCL12
6.45Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.45Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.25Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
6.25Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.25Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
6.25Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
6.25Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
6.06Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.06Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
6.06Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.06Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.88Single3OE8IT1t3OE8-CXCR4-IT1t
5.88Single4XNWMRS25004XNW-P2Y1-MRS2500
5.88Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single6ME5Agomelatine6ME5-MT1-Agomelatine
5.88Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.88Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
5.88Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
5.88Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.88Single8GGZEpinephrine8GGZ-β2-Epinephrine
5.88Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
5.88Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.88Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.56Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.56Single5L7IVismodegib5L7I-SMO-Vismodegib
5.56Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.56Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.56Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.56Single7UL2SR486927UL2-NTS1-SR48692-Na
5.56Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
5.56Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.56Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.56Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
5.56Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.56Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.56Consensusclass-t_onOrthosteric Ligandtaste2_on
5.56Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.56Consensusgo_proteinOrthosteric Ligandgo_chemokine
5.56Consensusgs_class-tOrthosteric Ligandgs_taste
5.56Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.56Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.56Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
5.56Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
5.41Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.26Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.26Single4QINSAG1.54QIN-SMO-SAG1.5
5.26Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.26Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.26Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.26Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
5.26Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.26Single8HNNSCH5467388HNN-CXCR3-SCH546738
5.26Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
5.26Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
5.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.26Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.26Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
5.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
5.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.00Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.00Consensusgi_class-fOrthosteric Ligandgi_frizzled
5.00Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
5.00Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
5.00Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single4YAYZD-71554YAY-AT1-ZD-7155
4.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
4.76Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
4.76Single5T04Neurotensin5T04-NTS1-Neurotensin
4.76Single6D27CAY104716D27-DP2-CAY10471
4.76Single6GPSMK08126GPS-CCR2-MK0812
4.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.76Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.76Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.76Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.76Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.76Consensushcar_offOrthosteric Ligandsuccinate_off
4.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.55Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
4.55Single6GPXMK08126GPX-CCR2-MK0812
4.55Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.55Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.35Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
4.35Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.35Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
4.35Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
4.17Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
4.17Single6OS2TRV0266OS2-AT1-TRV026
4.17Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
4.17Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensuschemokine_offOrthosteric Ligandcxcr_off
4.17Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.17Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.17Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
4.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
4.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
3.70Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.70Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
3.57Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
3.57Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
3.57Single7SK5CXCL127SK5-ACKR3-CXCL12
3.45Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
3.23Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.78Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

PDB Summary
PDB 7E9G
Class C
SubFamily Aminoacid
Type Metabotropic glutamate
SubType mGlu2; mGlu2
Species Homo sapiens
Ligand Eglumetad
Other Ligand(s) JNJ-40411813
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.5
Date 2021-06-23
D.O.I. 10.1038/s41586-021-03495-2
Net Summary
Imin 1.58
Number of Linked Nodes 1986
Number of Links 3152
Number of Hubs 727
Number of Links mediated by Hubs 2430
Number of Communities 45
Number of Nodes involved in Communities 1055
Number of Links involved in Communities 1920
Path Summary
Number Of Nodes in MetaPath 1094
Number Of Links MetaPath 1093
Number of Shortest Paths 1157364638
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 84
Minimum Path Strength 1.295
Average Path Strength 8.0876
Maximum Path Strength 29.5
Minimum Path Correlation 0.71
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 128
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code40F
PDB ResiduesL:L:?901 M:M:?901
Environment DetailsOpen EMBL-EBI Page
Code40F
Name(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Synonyms
Identifier(1S,2S,5R,6S)-2-azanylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
FormulaC8 H11 N O4
Molecular Weight185.177
SMILESC1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N
PubChem213056
Formal Charge0
Total Atoms24
Total Chiral Atoms4
Total Bonds25
Total Aromatic Bonds0

CodeHZR
PDB ResiduesW:W:?902
Environment DetailsOpen EMBL-EBI Page
CodeHZR
NameJNJ-40411813
SynonymsJNJ-40411813
Identifier1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one
FormulaC20 H25 Cl N2 O
Molecular Weight344.878
SMILESCCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)c3ccccc3
PubChem25195461
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_Chain_R
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLIT 
GVIGGSYSD VSIQVANLL RLFQIPQIS YASTSAKLS DKSRYDYFA 
RTVPPDFFQ AKAMAEILR FFNWTYVST VASEGDYGE TGIEAFELE 
ARARNICVA TSEKVGRAM SRAAFEGVV RALLQKPSA RVAVLFTRS 
EDARELLAA SQRLNASFT WVASDGWGA LESVVAGSE GAAEGAITI 
ELASYPISD FASYFQSLD PWNNSRNPW FREFWEQRF RCSFRQRDC 
AAHSLRAVP FEQESKIMF VVNAVYAMA HALHNMHRA LCPNTTRLC 
DAMRPVNGR RLYKDFVLN VKFDAPFRP ADTHNEVRF DRFGDGIGR 
YNIFTYLRA GSGRYRYQK VGYWAEGLT LDTSLIPWA SPSAGPLPA 
SRCSEPCLQ NEVKSVQPG EVCCWLCIP CQPYEYRLD EFTCADCGL 
GYWPNASLT GCFELPQEY IRWGDAWAV GPVTIACLG ALATLFVLG 
VFVRHNATP VVKAAGREL CYILLGGVF LCYCMTFIF IAKPSTAVC 
TLRRLGLGT AFSVCYSAL LTKTNRIAR IFGGAREGA QRPRFISPA 
SQVAICLAL ISGQLLIVV AWLVVEAPG TGKETAPER REVVTLRCN 
HRDASMLGS LAYNVLLIA LCTLYAFKT RKCPENFNE AKFIGFTMY 
TTCIIWLAF LPIFYVTSS DYRVQTTTM CVSVSLSGS VVLGCLFAP 
KLHI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ14416
Sequence
>7E9G_Chain_S
KKVLTLEGD LVLGGLFPV HQKGGPAED CGPVNEHRG IQRLEAMLF 
ALDRINRDP HLLPGVRLG AHILDSCSK DTHALEQAL DFVRASLTA 
ITGVIGGSY SDVSIQVAN LLRLFQIPQ ISYASTSAK LSDKSRYDY 
FARTVPPDF FQAKAMAEI LRFFNWTYV STVASEGDY GETGIEAFE 
LEARARNIC VATSEKVGR AMSRAAFEG VVRALLQKP SARVAVLFT 
RSEDARELL AASQRLNAS FTWVASDGW GALESVVAG SEGAAEGAI 
TIELASYPI SDFASYFQS LDPWNNSRN PWFREFWEQ RFRCSFRQR 
DCAAHSLRA VPFEQESKI MFVVNAVYA MAHALHNMH RALCPNTTR 
LCDAMRPVN GRRLYKDFV LNVKFDAPF RPADTHNEV RFDRFGDGI 
GRYNIFTYL RAGSGRYRY QKVGYWAEG LTLDTSLIP WASPSAGPL 
PASRCSEPC LQNEVKSVQ PGEVCCWLC IPCQPYEYR LDEFTCADC 
GLGYWPNAS LTGCFELPQ EYIRWGDAW AVGPVTIAC LGALATLFV 
LGVFVRHNA TPVVKAAGR ELCYILLGG VFLCYCMTF IFIAKPSTA 
VCTLRRLGL GTAFSVCYS ALLTKTNRI SPASQVAIC LALISGQLL 
IVVAWLVVE APGTGKETA PERREVVTL RCNHRDASM LGSLAYNVL 
LIALCTLYA FKTRKCPEN FNEAKFIGF TMYTTCIIW LAFLPIFYV 
TSSDYRVQT TTMCVSVSL SGSVVLGCL FAPKLHII


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7E9G_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKNTIV 
KQMKITGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLAEDEE MNRMHASMK LFDSICNNK WFTDTSIIL 
FLNKKDLFE EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN 
KRKDTKEIY THFTCSTDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7E9G_Chain_B
LSQITNNID PVGRIQMRT RRTLRGHLA KIYAMHWGT DSRLLVSAS 
QDGKLIIWD SYTTNKVHA IPLRSSWVM TCAYAPSGN YVACGGLDN 
ICSIYNLKT REGNVRVSR ELAGHTGYL SCCRFLDDN QIVTSSGDT 
TCALWDIET GQQTTTFTG HTGDVMSLS LAPDTRLFV SGACDASAK 
LWDVREGMC RQTFTGHES DINAICFFP NGNAFATGS DDATCRLFD 
LRADQELMT YSHDNIICG ITSVSFSKS GRLLLAGYD DFNCNVWDA 
LKADRAGVL AGHDNRVSC LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7E9G_Chain_G
KVSKAAADL MAYCEAHAK EDPLLTPVP ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
mglu2_on7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7E9GCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetadJNJ-40411813Gi1/&β;1/&γ;23.52021-06-2310.1038/s41586-021-03495-2
7EPACAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens---3.62021-06-2310.1038/s41586-021-03641-w
7EPBCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensEglumetad--3.12021-06-2310.1038/s41586-021-03641-w
7EPFCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiens-NAM597-2.72021-06-2310.1038/s41586-021-03641-w
7MTQCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensLY341495--3.652021-07-0710.1038/s41586-021-03680-3
7MTRCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164-3.32021-07-0710.1038/s41586-021-03680-3
7MTSCAminoacidMetabotropic glutamatemGlu2; mGlu2Homo sapiensGlutamateADX55164Gi1/&β;1/&γ;23.22021-07-0710.1038/s41586-021-03680-3
8JCUCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.82023-06-2110.1038/s41422-023-00830-2
8JCVCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--3.42023-06-2110.1038/s41422-023-00830-2
8JCWCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCXCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JCYCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--2.92023-06-2110.1038/s41422-023-00830-2
8JCZCAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensLY341495--32023-06-2110.1038/s41422-023-00830-2
8JD0CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateJ9R-3.32023-06-2110.1038/s41422-023-00830-2
8JD1CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--3.72023-06-2110.1038/s41422-023-00830-2
8JD2CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamate--2.82023-06-2110.1038/s41422-023-00830-2
8JD3CAminoacidMetabotropic glutamatemGlu2; mGlu3Homo sapiensGlutamateHZR; PEFGi1/&β;1/&γ;23.32023-06-2110.1038/s41422-023-00830-2
8JD4CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamate--2.92023-06-2110.1038/s41422-023-00830-2
8JD5CAminoacidMetabotropic glutamatemGlu2; mGlu4Homo sapiensGlutamateBQI; HZE; PEFGi1/&β;1/&γ;23.62023-06-2110.1038/s41422-023-00830-2
7EPDCAminoacidMetabotropic glutamatemGlu2, mGlu7Homo sapiens---3.92021-06-2310.1038/s41586-021-03641-w




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