Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E9G | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu2 | Homo sapiens | Eglumetad | JNJ-40411813 | Gi1/Beta1/Gamma2 | 3.5 | 2021-06-23 | 10.1038/s41586-021-03495-2 |
![](/psngpcr/ligands/40F/40F_7E9G_L_L_901.png)
A 2D representation of the interactions of 40F in 7E9G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F38 | R:R:P39 | 2.89 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | R:R:F38 | R:R:R61 | 2.14 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | R:R:F38 | R:R:Y165 | 22.69 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:P39 | R:R:S93 | 1.78 | 1 | Yes | No | 5 | 1 | 2 | 2 | R:R:P39 | R:R:S143 | 7.13 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:P39 | R:R:Y144 | 6.95 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:K43 | R:R:R243 | 7.43 | 1 | Yes | Yes | 3 | 2 | 2 | 2 | R:R:K43 | R:R:R271 | 2.48 | 1 | Yes | Yes | 3 | 5 | 2 | 1 | R:R:E273 | R:R:K43 | 4.05 | 1 | Yes | Yes | 1 | 3 | 2 | 2 | R:R:R57 | R:R:R61 | 13.86 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:R57 | R:R:S272 | 9.22 | 1 | Yes | No | 4 | 2 | 1 | 2 | R:R:G296 | R:R:R57 | 3 | 1 | No | Yes | 5 | 4 | 1 | 1 | R:R:L300 | R:R:R57 | 4.86 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:E375 | R:R:R57 | 11.63 | 1 | No | Yes | 5 | 4 | 2 | 1 | L:L:?901 | R:R:R57 | 17.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:R61 | R:R:S143 | 5.27 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:R61 | R:R:Y165 | 3.09 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | R:R:A166 | R:R:R61 | 4.15 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | R:R:E375 | R:R:R61 | 8.14 | 1 | No | Yes | 5 | 4 | 2 | 1 | R:R:K377 | R:R:R61 | 11.14 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | R:R:I378 | R:R:R61 | 2.51 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | R:R:R61 | R:R:V381 | 3.92 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?901 | R:R:R61 | 8.52 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:S93 | R:R:Y144 | 8.9 | 1 | No | Yes | 1 | 3 | 2 | 1 | R:R:R271 | R:R:S93 | 2.64 | 1 | Yes | No | 5 | 1 | 1 | 2 | R:R:S143 | R:R:Y165 | 6.36 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | R:R:A166 | R:R:S143 | 3.42 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?901 | R:R:S143 | 2.11 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:V147 | R:R:Y144 | 3.79 | 1 | Yes | Yes | 4 | 3 | 2 | 1 | R:R:R271 | R:R:Y144 | 22.64 | 1 | Yes | Yes | 5 | 3 | 1 | 1 | R:R:E273 | R:R:Y144 | 3.37 | 1 | Yes | Yes | 1 | 3 | 2 | 1 | L:L:?901 | R:R:Y144 | 4.11 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S145 | R:R:S169 | 6.52 | 1 | No | Yes | 8 | 7 | 1 | 2 | R:R:S145 | R:R:Y216 | 5.09 | 1 | No | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:S145 | 4.21 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:D146 | R:R:V147 | 2.92 | 1 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:D146 | R:R:R243 | 13.1 | 1 | Yes | Yes | 5 | 2 | 2 | 2 | R:R:D146 | R:R:R271 | 3.57 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:A166 | R:R:Y165 | 2.67 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | R:R:V381 | R:R:Y165 | 8.83 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:A166 | R:R:K377 | 3.21 | 1 | Yes | Yes | 5 | 3 | 1 | 1 | L:L:?901 | R:R:A166 | 5.53 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:T168 | R:R:V185 | 4.76 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:D188 | R:R:T168 | 5.78 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:T168 | R:R:Y216 | 4.99 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:D295 | R:R:T168 | 4.34 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:T168 | 5.17 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:K377 | R:R:V185 | 3.04 | 1 | Yes | Yes | 3 | 7 | 1 | 2 | R:R:F380 | R:R:V185 | 11.8 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:D188 | R:R:Q191 | 3.92 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:D188 | R:R:Y216 | 8.05 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:Q191 | R:R:Y216 | 3.38 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D295 | R:R:Q191 | 13.05 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:Q191 | R:R:Y453 | 18.04 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:R271 | R:R:S212 | 3.95 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:D274 | R:R:S212 | 5.89 | 1 | Yes | Yes | 4 | 6 | 2 | 2 | R:R:F269 | R:R:Y216 | 3.09 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S294 | R:R:Y216 | 8.9 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:D295 | R:R:Y216 | 3.45 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:Y216 | 24.68 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:R243 | R:R:R271 | 19.19 | 1 | Yes | Yes | 2 | 5 | 2 | 1 | R:R:F269 | R:R:S294 | 5.28 | 1 | Yes | No | 7 | 8 | 2 | 2 | R:R:E273 | R:R:R271 | 13.96 | 1 | Yes | Yes | 1 | 5 | 2 | 1 | R:R:D274 | R:R:R271 | 4.76 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?901 | R:R:R271 | 2.56 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L300 | R:R:S272 | 3 | 1 | Yes | No | 5 | 2 | 2 | 2 | R:R:D274 | R:R:E273 | 2.6 | 1 | Yes | Yes | 4 | 1 | 2 | 2 | R:R:G296 | R:R:S294 | 1.86 | 1 | No | No | 5 | 8 | 1 | 2 | R:R:D295 | R:R:E318 | 3.9 | 1 | Yes | Yes | 8 | 6 | 1 | 2 | R:R:D295 | R:R:L319 | 5.43 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | R:R:D295 | R:R:Y453 | 4.6 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | L:L:?901 | R:R:D295 | 2.86 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?901 | R:R:G296 | 3.6 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:E318 | R:R:L319 | 5.3 | 1 | Yes | Yes | 6 | 4 | 2 | 2 | R:R:E318 | R:R:K377 | 4.05 | 1 | Yes | Yes | 6 | 3 | 2 | 1 | R:R:K377 | R:R:L319 | 4.23 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | R:R:F380 | R:R:L319 | 8.53 | 1 | Yes | Yes | 6 | 4 | 2 | 2 | R:R:L319 | R:R:Y453 | 10.55 | 1 | Yes | Yes | 4 | 8 | 2 | 2 | R:R:F380 | R:R:K377 | 2.48 | 1 | Yes | Yes | 6 | 3 | 2 | 1 | L:L:?901 | R:R:K377 | 6.93 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 10.00 | Average Interaction Strength | 7.35 | Average Nodes In Shell | 39.00 | Average Hubs In Shell | 33.00 | Average Links In Shell | 80.00 | Average Links Mediated by Hubs In Shell | 79.00 |
| ![](/psngpcr/ligands/40F/40F_7E9G_L_L_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/40F/40F_7E9G_L_L_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/40F/40F_7E9G_M_M_901.png)
A 2D representation of the interactions of 40F in 7E9G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:F38 | S:S:R61 | 2.14 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | S:S:F38 | S:S:Y165 | 16.5 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:F38 | S:S:V381 | 3.93 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:P39 | S:S:R61 | 2.88 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:P39 | S:S:S93 | 1.78 | 1 | Yes | No | 5 | 1 | 2 | 2 | S:S:P39 | S:S:S143 | 7.13 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:P39 | S:S:Y144 | 5.56 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:K43 | S:S:S93 | 3.06 | 1 | Yes | No | 3 | 1 | 2 | 2 | S:S:K43 | S:S:R243 | 8.66 | 1 | Yes | Yes | 3 | 2 | 2 | 2 | S:S:K43 | S:S:R271 | 4.95 | 1 | Yes | Yes | 3 | 5 | 2 | 1 | S:S:R57 | S:S:R61 | 8.53 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | S:S:R57 | S:S:S272 | 3.95 | 1 | Yes | No | 4 | 2 | 1 | 2 | S:S:G296 | S:S:R57 | 3 | 0 | No | Yes | 5 | 4 | 2 | 1 | S:S:L300 | S:S:R57 | 12.15 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:E375 | S:S:R57 | 6.98 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | M:M:?901 | S:S:R57 | 18.75 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:R61 | S:S:S143 | 10.54 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | S:S:R61 | S:S:Y165 | 7.2 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | S:S:A166 | S:S:R61 | 2.77 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | S:S:E375 | S:S:R61 | 17.45 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:K377 | S:S:R61 | 4.95 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | S:S:I378 | S:S:R61 | 2.51 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | S:S:R61 | S:S:V381 | 3.92 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | M:M:?901 | S:S:R61 | 7.67 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:S93 | S:S:Y144 | 11.45 | 1 | No | Yes | 1 | 3 | 2 | 1 | S:S:S143 | S:S:Y165 | 7.63 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | S:S:A166 | S:S:S143 | 3.42 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | M:M:?901 | S:S:S143 | 4.21 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:R271 | S:S:Y144 | 19.55 | 1 | Yes | Yes | 5 | 3 | 1 | 1 | S:S:E273 | S:S:Y144 | 8.98 | 1 | No | Yes | 1 | 3 | 2 | 1 | M:M:?901 | S:S:Y144 | 5.76 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:S145 | S:S:S167 | 1.63 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:S145 | S:S:S169 | 4.89 | 1 | Yes | No | 8 | 7 | 1 | 2 | S:S:S145 | S:S:Y216 | 5.09 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?901 | S:S:S145 | 4.21 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:D146 | S:S:R243 | 5.96 | 1 | Yes | Yes | 5 | 2 | 2 | 2 | S:S:D146 | S:S:R271 | 3.57 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | S:S:A166 | S:S:Y165 | 2.67 | 1 | Yes | Yes | 5 | 8 | 1 | 2 | S:S:V381 | S:S:Y165 | 10.09 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | S:S:A166 | S:S:K377 | 4.82 | 1 | Yes | Yes | 5 | 3 | 1 | 1 | M:M:?901 | S:S:A166 | 5.53 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | S:S:T168 | S:S:V185 | 4.76 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | S:S:D188 | S:S:T168 | 4.34 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:T168 | S:S:Y216 | 4.99 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | S:S:D295 | S:S:T168 | 4.34 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | M:M:?901 | S:S:T168 | 5.17 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:D188 | S:S:S169 | 2.94 | 1 | Yes | No | 8 | 7 | 2 | 2 | S:S:F380 | S:S:V185 | 7.87 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | S:S:D188 | S:S:Y216 | 9.2 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:R271 | S:S:S212 | 3.95 | 1 | Yes | Yes | 5 | 6 | 1 | 2 | S:S:D274 | S:S:S212 | 5.89 | 1 | Yes | Yes | 4 | 6 | 2 | 2 | S:S:G217 | S:S:Y216 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | S:S:S294 | S:S:Y216 | 6.36 | 0 | No | Yes | 8 | 7 | 2 | 1 | M:M:?901 | S:S:Y216 | 26.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:R243 | S:S:R271 | 10.66 | 1 | Yes | Yes | 2 | 5 | 2 | 1 | S:S:E273 | S:S:R271 | 11.63 | 1 | No | Yes | 1 | 5 | 2 | 1 | S:S:D274 | S:S:R271 | 4.76 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | M:M:?901 | S:S:R271 | 2.56 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | S:S:L300 | S:S:S272 | 3 | 1 | Yes | No | 5 | 2 | 2 | 2 | S:S:D274 | S:S:E273 | 2.6 | 1 | Yes | No | 4 | 1 | 2 | 2 | S:S:D295 | S:S:K377 | 2.77 | 1 | Yes | Yes | 8 | 3 | 2 | 1 | S:S:E375 | S:S:K377 | 4.05 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:E375 | S:S:I378 | 4.1 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | S:S:F380 | S:S:K377 | 2.48 | 1 | Yes | Yes | 6 | 3 | 2 | 1 | M:M:?901 | S:S:K377 | 9.89 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 10.00 | Average Interaction Strength | 9.01 | Average Nodes In Shell | 35.00 | Average Hubs In Shell | 28.00 | Average Links In Shell | 65.00 | Average Links Mediated by Hubs In Shell | 65.00 |
| ![](/psngpcr/ligands/40F/40F_7E9G_M_M_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/40F/40F_7E9G_M_M_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EPB | C | Aminoacid | Metabotropic glutamate | mGlu2; mGlu2 | Homo sapiens | Eglumetad | - | - | 3.1 | 2021-06-23 | 10.1038/s41586-021-03641-w |
![](/psngpcr/ligands/40F/40F_7EPB_L_L_901.png)
A 2D representation of the interactions of 40F in 7EPB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:P39 | R:R:S143 | 8.91 | 1 | Yes | No | 5 | 4 | 2 | 2 | R:R:P39 | R:R:Y144 | 5.56 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:N54 | R:R:R57 | 7.23 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:R57 | R:R:R61 | 6.4 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:R57 | R:R:S272 | 5.27 | 1 | Yes | No | 4 | 2 | 1 | 2 | R:R:L300 | R:R:R57 | 7.29 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:E375 | R:R:R57 | 9.3 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:K377 | R:R:R57 | 3.71 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | L:L:?901 | R:R:R57 | 16.2 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:R61 | R:R:Y165 | 8.23 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | R:R:A166 | R:R:R61 | 4.15 | 1 | No | Yes | 5 | 4 | 1 | 1 | R:R:E375 | R:R:R61 | 11.63 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | R:R:K377 | R:R:R61 | 11.14 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | L:L:?901 | R:R:R61 | 8.52 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:S93 | R:R:Y144 | 8.9 | 0 | No | Yes | 1 | 3 | 2 | 1 | R:R:S143 | R:R:Y144 | 5.09 | 1 | No | Yes | 4 | 3 | 2 | 1 | R:R:S143 | R:R:Y165 | 5.09 | 1 | No | Yes | 4 | 8 | 2 | 2 | R:R:D146 | R:R:Y144 | 3.45 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:R271 | R:R:Y144 | 24.69 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | L:L:?901 | R:R:Y144 | 4.94 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:S145 | R:R:S167 | 3.26 | 1 | Yes | No | 8 | 8 | 1 | 2 | R:R:S145 | R:R:S169 | 4.89 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:D215 | R:R:S145 | 5.89 | 1 | Yes | Yes | 5 | 8 | 2 | 1 | R:R:S145 | R:R:Y216 | 6.36 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:S145 | 6.32 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:D146 | R:R:D215 | 3.99 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:D146 | R:R:R271 | 5.96 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:A166 | R:R:K377 | 3.21 | 1 | No | Yes | 5 | 3 | 1 | 1 | L:L:?901 | R:R:A166 | 3.32 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:T168 | R:R:V185 | 3.17 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:D188 | R:R:T168 | 5.78 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:T168 | R:R:Y216 | 4.99 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:D295 | R:R:T168 | 2.89 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:T168 | 3.1 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:D215 | R:R:S169 | 8.83 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:L319 | R:R:V185 | 2.98 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:F380 | R:R:V185 | 7.87 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:D188 | R:R:Q191 | 5.22 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:D188 | R:R:Y216 | 11.49 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D188 | R:R:F269 | 3.58 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:Q191 | R:R:Y216 | 5.64 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:Q191 | R:R:S294 | 4.33 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:D295 | R:R:Q191 | 13.05 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:F269 | R:R:Y216 | 8.25 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:S294 | R:R:Y216 | 6.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:D295 | R:R:Y216 | 9.2 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?901 | R:R:Y216 | 13.98 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F269 | R:R:S294 | 11.89 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:D295 | R:R:S294 | 4.42 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:D295 | R:R:L319 | 4.07 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | R:R:D295 | R:R:K377 | 5.53 | 1 | Yes | Yes | 8 | 3 | 1 | 1 | L:L:?901 | R:R:D295 | 6.67 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F380 | R:R:L319 | 8.53 | 1 | Yes | Yes | 6 | 4 | 2 | 2 | R:R:E375 | R:R:K377 | 4.05 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | R:R:F380 | R:R:K377 | 6.2 | 1 | Yes | Yes | 6 | 3 | 2 | 1 | L:L:?901 | R:R:K377 | 6.93 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:?901 | R:R:G296 | 2.4 | 1 | Yes | No | 0 | 5 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 7.24 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 23.00 | Average Links In Shell | 57.00 | Average Links Mediated by Hubs In Shell | 57.00 |
| ![](/psngpcr/ligands/40F/40F_7EPB_L_L_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/40F/40F_7EPB_L_L_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/40F/40F_7EPB_M_M_901.png)
A 2D representation of the interactions of 40F in 7EPB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | S:S:P39 | S:S:S143 | 8.91 | 1 | Yes | No | 5 | 4 | 2 | 2 | S:S:P39 | S:S:Y144 | 2.78 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:N54 | S:S:R57 | 8.44 | 0 | No | Yes | 4 | 4 | 2 | 1 | S:S:R57 | S:S:R61 | 7.46 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | S:S:R57 | S:S:S272 | 7.91 | 1 | Yes | No | 4 | 2 | 1 | 2 | S:S:L300 | S:S:R57 | 7.29 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:E375 | S:S:R57 | 9.3 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | M:M:?901 | S:S:R57 | 17.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:R61 | S:S:Y165 | 7.2 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | S:S:A166 | S:S:R61 | 4.15 | 1 | No | Yes | 5 | 4 | 1 | 1 | S:S:E375 | S:S:R61 | 9.3 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | S:S:K377 | S:S:R61 | 9.9 | 1 | Yes | Yes | 3 | 4 | 1 | 1 | M:M:?901 | S:S:R61 | 8.52 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | S:S:S93 | S:S:Y144 | 7.63 | 0 | No | Yes | 1 | 3 | 2 | 1 | S:S:S143 | S:S:Y144 | 5.09 | 1 | No | Yes | 4 | 3 | 2 | 1 | S:S:S143 | S:S:Y165 | 5.09 | 1 | No | Yes | 4 | 8 | 2 | 2 | S:S:D146 | S:S:Y144 | 3.45 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:R271 | S:S:Y144 | 26.75 | 1 | No | Yes | 5 | 3 | 2 | 1 | M:M:?901 | S:S:Y144 | 4.94 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | S:S:S145 | S:S:S167 | 3.26 | 1 | Yes | No | 8 | 8 | 1 | 2 | S:S:S145 | S:S:S169 | 6.52 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | S:S:D215 | S:S:S145 | 5.89 | 1 | Yes | Yes | 5 | 8 | 2 | 1 | S:S:S145 | S:S:Y216 | 6.36 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?901 | S:S:S145 | 5.27 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:D146 | S:S:R271 | 5.96 | 1 | Yes | No | 5 | 5 | 2 | 2 | S:S:A166 | S:S:K377 | 3.21 | 1 | No | Yes | 5 | 3 | 1 | 1 | M:M:?901 | S:S:A166 | 5.53 | 1 | Yes | No | 0 | 5 | 0 | 1 | S:S:T168 | S:S:V185 | 3.17 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | S:S:D188 | S:S:T168 | 5.78 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:T168 | S:S:Y216 | 3.75 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | S:S:D295 | S:S:T168 | 4.34 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?901 | S:S:T168 | 3.1 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:D215 | S:S:S169 | 8.83 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | S:S:L319 | S:S:V185 | 2.98 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | S:S:F380 | S:S:V185 | 5.24 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | S:S:D188 | S:S:Q191 | 5.22 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:D188 | S:S:Y216 | 11.49 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:D188 | S:S:F269 | 3.58 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | S:S:Q191 | S:S:Y216 | 5.64 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:Q191 | S:S:S294 | 4.33 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | S:S:D295 | S:S:Q191 | 14.36 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:F269 | S:S:Y216 | 7.22 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | S:S:S294 | S:S:Y216 | 6.36 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | S:S:D295 | S:S:Y216 | 8.05 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | M:M:?901 | S:S:Y216 | 15.63 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | S:S:F269 | S:S:S294 | 9.25 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | S:S:D295 | S:S:S294 | 4.42 | 1 | Yes | Yes | 8 | 8 | 1 | 2 | S:S:D295 | S:S:L319 | 4.07 | 1 | Yes | Yes | 8 | 4 | 1 | 2 | S:S:D295 | S:S:K377 | 5.53 | 1 | Yes | Yes | 8 | 3 | 1 | 1 | M:M:?901 | S:S:D295 | 5.71 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | S:S:E375 | S:S:L300 | 3.98 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | S:S:F380 | S:S:L319 | 8.53 | 1 | Yes | Yes | 6 | 4 | 2 | 2 | S:S:E375 | S:S:K377 | 5.4 | 1 | Yes | Yes | 5 | 3 | 2 | 1 | S:S:F380 | S:S:K377 | 8.69 | 1 | Yes | Yes | 6 | 3 | 2 | 1 | M:M:?901 | S:S:K377 | 7.92 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | M:M:?901 | S:S:G296 | 2.4 | 1 | Yes | No | 0 | 5 | 0 | 1 | |
Statistics | Value |
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Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 7.69 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 23.00 | Average Links In Shell | 56.00 | Average Links Mediated by Hubs In Shell | 56.00 |
| ![](/psngpcr/ligands/40F/40F_7EPB_M_M_901_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/40F/40F_7EPB_M_M_901_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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