psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:E3	B:B:Q6	5.1	No	No	0	5	1
2	B:B:D5	B:B:L4	2.71	No	Yes	0	1	4
3	B:B:L4	B:B:R8	8.5	Yes	No	0	4	3
4	B:B:L4	G:G:S8	3	Yes	No	0	4	4
5	B:B:L7	G:G:A12	4.73	No	No	0	8	5
6	B:B:E12	B:B:Q9	5.1	No	No	0	4	3
7	B:B:E10	G:G:K20	4.05	No	No	0	8	6
8	B:B:L14	B:B:Q13	3.99	Yes	No	0	8	1
9	B:B:L14	B:B:Q17	2.66	Yes	No	0	8	4
10	B:B:L14	G:G:L19	4.15	Yes	Yes	0	8	9
11	B:B:L14	G:G:K20	8.46	Yes	No	0	8	6
12	B:B:K15	G:G:L19	2.82	No	Yes	0	6	9
13	B:B:N16	B:B:R19	8.44	No	No	0	1	4
14	B:B:Q17	G:G:A23	4.55	No	No	0	4	8
15	B:B:I18	B:B:R22	2.51	No	Yes	0	7	6
16	B:B:I18	G:G:A23	3.25	No	No	0	7	8
17	B:B:D20	B:B:R19	11.91	No	No	0	2	4
18	B:B:A21	G:G:R27	5.53	No	No	0	4	8
19	B:B:D258	B:B:R22	20.25	No	Yes	21	7	6
20	B:B:Q259	B:B:R22	5.84	No	Yes	0	6	6
21	B:B:R22	G:G:R27	2.13	Yes	No	21	6	8
22	B:B:C25	B:B:Q259	3.05	No	No	0	3	6
23	B:B:D27	G:G:K29	11.06	No	No	0	8	4
24	B:B:D27	G:G:S31	2.94	No	No	0	8	9
25	B:B:A28	B:B:Q32	4.55	No	No	0	4	1
26	B:B:Q32	B:B:T29	2.83	No	No	0	1	3
27	B:B:L30	B:B:T34	5.9	No	Yes	2	5	5
28	B:B:L30	B:B:M262	5.65	No	Yes	2	5	4
29	B:B:L30	B:B:L300	2.77	No	No	2	5	6
30	B:B:I33	B:B:T34	3.04	No	Yes	0	3	5
31	B:B:I33	G:G:A34	3.25	No	No	0	3	6
32	B:B:I33	G:G:M38	4.37	No	No	0	3	4
33	B:B:I37	B:B:T34	3.04	No	Yes	0	2	5
34	B:B:L300	B:B:T34	7.37	No	Yes	2	6	5
35	B:B:I37	B:B:R283	6.26	No	No	0	2	9
36	B:B:D38	B:B:P39	3.22	No	No	0	1	1
37	B:B:K301	B:B:P39	5.02	Yes	No	0	5	1
38	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
39	B:B:I43	B:B:V40	3.07	No	Yes	0	3	3
40	B:B:V40	G:G:L51	4.47	Yes	Yes	0	3	6
41	B:B:Q44	B:B:R42	9.35	No	No	0	4	2
42	B:B:G306	B:B:R42	6	No	No	0	4	2
43	B:B:I43	B:B:M45	4.37	No	No	0	3	4
44	B:B:Q44	B:B:R46	5.84	No	No	0	4	5
45	B:B:L308	B:B:M45	4.24	No	No	10	7	4
46	B:B:M45	B:B:W339	5.82	No	Yes	10	4	9
47	B:B:R46	B:B:R48	4.26	No	No	0	5	7
48	B:B:K337	B:B:T47	7.51	Yes	No	10	6	3
49	B:B:T47	B:B:W339	4.85	No	Yes	10	3	9
50	B:B:N340	B:B:R48	8.44	No	No	5	9	7
51	B:B:R48	G:G:F61	2.14	No	Yes	5	7	8
52	B:B:R49	B:B:T87	5.17	No	No	0	7	5
53	B:B:I338	B:B:R49	6.26	No	No	5	5	7
54	B:B:R49	G:G:F61	7.48	No	Yes	5	7	8
55	B:B:R52	B:B:T50	5.17	No	No	0	7	3
56	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
57	B:B:L51	B:B:W82	15.94	Yes	Yes	5	9	9
58	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
59	B:B:L336	B:B:L51	6.92	Yes	Yes	5	7	9
60	B:B:I338	B:B:L51	4.28	No	Yes	5	5	9
61	B:B:F335	B:B:R52	2.14	No	No	0	4	7
62	B:B:H54	B:B:I58	7.95	Yes	No	0	9	9
63	B:B:H54	B:B:S72	5.58	Yes	No	0	9	9
64	B:B:H54	B:B:S74	15.34	Yes	No	0	9	9
65	B:B:H54	B:B:I80	11.93	Yes	No	0	9	8
66	B:B:D76	B:B:L55	6.79	No	No	0	9	6
67	B:B:K57	B:B:Y59	2.39	No	Yes	1	9	8
68	B:B:K57	B:B:W332	24.37	No	Yes	1	9	9
69	A:A:E216	B:B:K57	4.05	No	No	0	7	9
70	B:B:G330	B:B:I58	1.76	No	No	5	5	9
71	B:B:I58	B:B:L336	2.85	No	Yes	5	9	7
72	B:B:Q75	B:B:Y59	13.53	Yes	Yes	1	9	8
73	B:B:W332	B:B:Y59	5.79	Yes	Yes	1	9	8
74	A:A:H213	B:B:Y59	2.18	Yes	Yes	1	8	8
75	B:B:A60	B:B:C103	1.81	No	No	0	7	8
76	B:B:M61	B:B:W63	3.49	Yes	Yes	5	6	7
77	B:B:C317	B:B:M61	4.86	No	Yes	0	7	6
78	B:B:G319	B:B:M61	1.75	No	Yes	5	5	6
79	B:B:L336	B:B:M61	2.83	Yes	Yes	5	7	6
80	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
81	B:B:H62	B:B:R150	12.41	No	No	0	6	6
82	B:B:L70	B:B:W63	4.56	No	Yes	5	5	7
83	B:B:S84	B:B:W63	6.18	No	Yes	5	5	7
84	B:B:G319	B:B:W63	2.81	No	Yes	5	5	7
85	B:B:T321	B:B:W63	10.92	Yes	Yes	5	7	7
86	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
87	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
88	B:B:D66	B:B:R68	3.57	No	No	0	8	5
89	B:B:D66	B:B:L69	5.43	No	No	0	8	5
90	B:B:S67	B:B:T321	4.8	No	Yes	5	5	7
91	B:B:D322	B:B:S67	4.42	No	No	0	1	5
92	B:B:D323	B:B:S67	10.31	No	No	5	7	5
93	B:B:D83	B:B:R68	13.1	No	No	0	8	5
94	B:B:R68	B:B:Y85	26.75	No	No	0	5	4
95	B:B:L69	B:B:Y105	2.34	No	Yes	0	5	6
96	B:B:L70	B:B:W82	4.56	No	Yes	5	5	9
97	B:B:L70	B:B:S84	4.5	No	No	5	5	5
98	B:B:I81	B:B:V71	3.07	Yes	No	0	7	8
99	B:B:V71	B:B:Y105	3.79	No	Yes	0	8	6
100	B:B:S72	B:B:W82	3.71	No	Yes	5	9	9
101	B:B:L336	B:B:S72	3	Yes	No	5	7	9
102	B:B:A73	B:B:C103	3.61	No	No	0	9	8
103	B:B:Q75	B:B:W99	4.38	Yes	Yes	1	9	9
104	A:A:C214	B:B:Q75	3.05	Yes	Yes	1	7	9
105	B:B:D76	B:B:K78	2.77	No	No	0	9	8
106	A:A:D26	B:B:K78	2.77	No	No	0	5	8
107	B:B:I93	B:B:L79	5.71	Yes	No	0	7	7
108	B:B:C114	B:B:L79	4.76	Yes	No	0	8	7
109	B:B:I80	B:B:W82	11.74	No	Yes	0	8	9
110	A:A:L23	B:B:I80	2.85	No	No	0	6	8
111	B:B:I81	B:B:V90	3.07	Yes	No	8	7	5
112	B:B:H91	B:B:I81	6.63	No	Yes	8	5	7
113	B:B:I81	B:B:L126	4.28	Yes	Yes	8	7	5
114	B:B:K89	B:B:W82	12.76	Yes	Yes	0	9	9
115	B:B:L336	B:B:W82	4.56	Yes	Yes	5	7	9
116	B:B:D83	B:B:T86	7.23	No	No	23	8	6
117	B:B:D83	B:B:N88	4.04	No	Yes	23	8	7
118	B:B:S84	G:G:F61	2.64	No	Yes	5	5	8
119	B:B:Y85	G:G:P60	13.91	No	No	5	4	9
120	B:B:Y85	G:G:F61	7.22	No	Yes	5	4	8
121	B:B:N88	B:B:T86	10.24	Yes	No	23	7	6
122	A:A:V13	B:B:N88	2.96	No	Yes	0	3	7
123	A:A:S16	B:B:N88	2.98	No	Yes	0	7	7
124	A:A:S16	B:B:K89	6.12	No	Yes	0	7	9
125	A:A:I19	B:B:K89	7.27	No	Yes	0	9	9
126	A:A:D20	B:B:K89	9.68	No	Yes	0	6	9
127	B:B:H91	B:B:V90	5.54	No	No	8	5	5
128	A:A:R15	B:B:H91	2.26	No	No	0	5	5
129	A:A:I19	B:B:A92	3.25	No	No	0	9	6
130	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
131	B:B:I93	B:B:Y124	3.63	Yes	Yes	8	7	6
132	B:B:I93	B:B:V133	4.61	Yes	No	8	7	4
133	B:B:L95	B:B:V100	4.47	Yes	No	8	8	9
134	B:B:C114	B:B:L95	4.76	Yes	Yes	8	8	8
135	B:B:L95	B:B:Y124	3.52	Yes	Yes	8	8	6
136	B:B:R96	B:B:V135	3.92	No	No	0	6	4
137	B:B:E138	B:B:R96	6.98	No	No	0	6	6
138	B:B:D118	B:B:S97	8.83	No	No	0	9	8
139	B:B:L117	B:B:W99	5.69	Yes	Yes	1	9	9
140	A:A:I184	B:B:W99	4.7	No	Yes	1	9	9
141	A:A:F199	B:B:W99	8.02	Yes	Yes	1	5	9
142	A:A:C214	B:B:W99	2.61	Yes	Yes	1	7	9
143	A:A:F215	B:B:W99	12.03	Yes	Yes	1	9	9
144	B:B:C114	B:B:V100	5.12	Yes	No	8	8	9
145	B:B:G116	B:B:M101	3.49	No	No	0	9	9
146	B:B:L117	B:B:M101	2.83	Yes	No	1	9	9
147	B:B:M101	B:B:Y145	3.59	No	Yes	1	9	8
148	B:B:G115	B:B:T102	1.82	No	No	0	9	8
149	B:B:C149	B:B:T102	3.38	Yes	No	0	8	8
150	B:B:A104	B:B:A113	1.79	No	No	1	7	9
151	B:B:A104	B:B:C149	1.81	No	Yes	1	7	8
152	B:B:A104	B:B:F151	2.77	No	Yes	1	7	9
153	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
154	B:B:V112	B:B:Y105	2.52	No	Yes	8	8	6
155	B:B:L126	B:B:Y105	3.52	Yes	Yes	8	5	6
156	B:B:A106	B:B:P107	1.87	No	No	0	6	6
157	B:B:A106	B:B:F151	6.93	No	Yes	0	6	9
158	B:B:G109	B:B:S108	1.86	No	No	0	5	6
159	B:B:N110	B:B:S108	7.45	No	No	0	4	6
160	B:B:D154	B:B:S108	4.42	No	No	0	6	6
161	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
162	B:B:K127	B:B:N110	6.99	No	No	0	4	4
163	B:B:N125	B:B:Y111	15.12	No	Yes	0	4	4
164	B:B:S136	B:B:Y111	2.54	No	Yes	0	4	4
165	B:B:F151	B:B:Y111	2.06	Yes	Yes	0	9	4
166	B:B:D154	B:B:Y111	8.05	No	Yes	0	6	4
167	B:B:V112	B:B:Y124	3.79	No	Yes	8	8	6
168	B:B:L126	B:B:V112	5.96	Yes	No	8	5	8
169	B:B:A113	B:B:C149	1.81	No	Yes	1	9	8
170	B:B:A113	B:B:F151	2.77	No	Yes	1	9	9
171	B:B:C114	B:B:G115	3.92	Yes	No	0	8	9
172	B:B:G115	B:B:G116	2.11	No	No	0	9	9
173	B:B:L117	B:B:Y145	4.69	Yes	Yes	1	9	8
174	A:A:W211	B:B:L117	2.28	Yes	Yes	1	9	9
175	B:B:D118	B:B:I120	2.8	No	No	0	9	6
176	B:B:G144	B:B:N119	3.39	No	No	0	8	9
177	A:A:G183	B:B:N119	3.39	No	No	0	9	9
178	B:B:E138	B:B:I120	4.1	No	No	0	6	6
179	B:B:C121	B:B:L139	3.17	No	No	0	8	9
180	B:B:C121	B:B:C149	1.82	No	Yes	0	8	8
181	B:B:C121	B:B:T159	3.38	No	Yes	0	8	9
182	B:B:S122	B:B:Y124	3.82	No	Yes	0	8	6
183	B:B:E138	B:B:S122	4.31	No	No	0	6	8
184	B:B:I123	B:B:R137	2.51	No	No	0	6	5
185	B:B:F151	B:B:I123	2.51	Yes	No	0	9	6
186	B:B:V133	B:B:Y124	2.52	No	Yes	8	4	6
187	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
188	B:B:N125	B:B:T128	4.39	No	Yes	24	4	3
189	B:B:N125	B:B:R134	9.64	No	No	24	4	3
190	B:B:L126	B:B:V133	2.98	Yes	No	8	5	4
191	B:B:E130	B:B:T128	2.82	No	Yes	0	3	3
192	B:B:R134	B:B:T128	3.88	No	Yes	24	3	3
193	B:B:E130	B:B:R129	2.33	No	No	0	3	3
194	B:B:R134	B:B:S136	3.95	No	No	0	3	4
195	B:B:I171	B:B:R137	2.51	No	No	0	6	5
196	B:B:G174	B:B:R137	3	No	No	0	4	5
197	B:B:L139	B:B:W169	19.36	No	Yes	0	9	8
198	B:B:H142	B:B:L146	6.43	Yes	No	1	9	7
199	B:B:H142	B:B:T159	4.11	Yes	Yes	1	9	9
200	B:B:H142	B:B:S161	16.74	Yes	No	1	9	9
201	B:B:D163	B:B:H142	8.82	Yes	Yes	1	9	9
202	B:B:H142	B:B:T165	5.48	Yes	No	1	9	7
203	B:B:A167	B:B:H142	2.93	No	Yes	1	4	9
204	B:B:H142	B:B:W169	2.12	Yes	Yes	1	9	8
205	B:B:D163	B:B:T143	7.23	Yes	No	0	9	5
206	B:B:G144	B:B:G162	2.11	No	Yes	0	8	9
207	B:B:G162	B:B:Y145	7.24	Yes	Yes	1	9	8
208	B:B:D186	B:B:Y145	5.75	Yes	Yes	1	9	8
209	B:B:M188	B:B:Y145	4.79	No	Yes	1	8	8
210	A:A:Q204	B:B:Y145	2.25	No	Yes	1	9	8
211	A:A:S206	B:B:Y145	5.09	No	Yes	1	8	8
212	A:A:K210	B:B:Y145	3.58	Yes	Yes	1	9	8
213	A:A:W211	B:B:Y145	3.86	Yes	Yes	1	9	8
214	B:B:L146	B:B:T159	4.42	No	Yes	1	7	9
215	B:B:S147	B:B:S160	4.89	No	No	0	9	6
216	B:B:C148	B:B:L190	6.35	No	Yes	0	6	5
217	B:B:L190	B:B:R150	2.43	Yes	No	0	5	6
218	B:B:L192	B:B:R150	2.43	No	No	0	5	6
219	B:B:F151	B:B:I157	7.54	Yes	No	1	9	7
220	B:B:F151	B:B:I171	2.51	Yes	No	1	9	6
221	B:B:L152	B:B:Q156	6.65	No	No	0	3	5
222	B:B:L152	B:B:L192	4.15	No	No	0	3	5
223	B:B:L152	B:B:T196	4.42	No	No	0	3	1
224	B:B:D153	B:B:Q156	14.36	No	No	0	5	5
225	B:B:D170	B:B:N155	5.39	No	No	14	9	3
226	B:B:E172	B:B:N155	6.57	No	No	14	6	3
227	B:B:I157	B:B:W169	3.52	No	Yes	1	7	8
228	B:B:I157	B:B:I171	5.89	No	No	1	7	6
229	B:B:L190	B:B:V158	2.98	Yes	No	0	5	5
230	B:B:L192	B:B:V158	4.47	No	No	0	5	5
231	B:B:F199	B:B:V158	3.93	Yes	No	0	9	5
232	B:B:T159	B:B:W169	8.49	Yes	Yes	1	9	8
233	B:B:S160	B:B:V187	4.85	No	No	0	6	9
234	B:B:L190	B:B:S160	3	Yes	No	0	5	6
235	B:B:G162	B:B:S161	3.71	Yes	No	1	9	9
236	B:B:D163	B:B:S161	8.83	Yes	No	1	9	9
237	B:B:D186	B:B:G162	3.35	Yes	Yes	1	9	9
238	B:B:D163	B:B:T165	10.12	Yes	No	1	9	7
239	B:B:G185	B:B:T164	1.82	No	No	0	5	6
240	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
241	B:B:C166	B:B:S201	3.44	No	No	0	8	9
242	B:B:A167	B:B:W169	5.19	No	Yes	1	4	8
243	B:B:A167	B:B:Q176	6.06	No	Yes	1	4	4
244	B:B:L168	B:B:T178	4.42	No	Yes	0	6	4
245	B:B:L168	B:B:V213	2.98	No	No	0	6	4
246	B:B:Q176	B:B:W169	14.24	Yes	Yes	1	4	8
247	B:B:D170	B:B:E172	2.6	No	No	14	9	6
248	B:B:D170	B:B:T173	4.34	No	No	14	9	5
249	B:B:G174	B:B:T173	1.82	No	No	14	4	5
250	B:B:Q175	B:B:T173	4.25	No	No	14	4	5
251	B:B:G174	B:B:Q175	3.29	No	No	14	4	4
252	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
253	B:B:T177	B:B:T178	3.14	No	Yes	0	4	4
254	B:B:F180	B:B:T178	6.49	Yes	Yes	6	7	4
255	B:B:G216	B:B:T178	1.82	No	Yes	6	4	4
256	B:B:F180	B:B:F199	7.5	Yes	Yes	6	7	9
257	B:B:F180	B:B:W211	14.03	Yes	Yes	6	7	8
258	B:B:F180	B:B:G216	4.52	Yes	No	6	7	4
259	B:B:G182	B:B:T181	1.82	No	No	0	6	2
260	B:B:G182	B:B:K209	1.74	No	Yes	0	6	6
261	B:B:H183	B:B:V187	5.54	Yes	No	6	9	9
262	B:B:H183	B:B:S201	4.18	Yes	No	6	9	9
263	B:B:A203	B:B:H183	5.85	No	Yes	6	8	9
264	B:B:D205	B:B:H183	6.3	Yes	Yes	6	9	9
265	B:B:H183	B:B:K209	13.1	Yes	Yes	6	9	6
266	B:B:H183	B:B:W211	4.23	Yes	Yes	6	9	8
267	B:B:G185	B:B:T184	1.82	No	No	0	5	3
268	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
269	B:B:C204	B:B:D186	3.11	Yes	Yes	1	7	9
270	A:A:S206	B:B:D186	4.42	No	Yes	1	8	9
271	A:A:E207	B:B:D186	5.2	No	Yes	0	9	9
272	B:B:A203	B:B:V187	3.39	No	No	6	8	9
273	B:B:C204	B:B:M188	4.86	Yes	No	1	7	8
274	A:A:K210	B:B:M188	5.76	Yes	No	1	9	8
275	B:B:G202	B:B:S189	1.86	No	No	0	6	7
276	B:B:I232	B:B:S189	4.64	Yes	No	0	8	7
277	B:B:S191	B:B:V200	3.23	No	Yes	2	8	6
278	B:B:I232	B:B:S191	3.1	Yes	No	2	8	8
279	B:B:F234	B:B:S191	5.28	No	No	2	5	8
280	B:B:A193	B:B:P194	1.87	No	No	0	4	4
281	B:B:A193	B:B:F234	2.77	No	No	0	4	5
282	B:B:G238	B:B:P194	4.06	No	No	0	7	4
283	B:B:D195	B:B:R197	4.76	No	No	0	5	5
284	B:B:L198	B:B:L210	5.54	No	Yes	0	3	5
285	B:B:D212	B:B:L198	2.71	Yes	No	0	9	3
286	B:B:F199	B:B:W211	13.03	Yes	Yes	6	9	8
287	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
288	B:B:L210	B:B:V200	2.98	Yes	Yes	0	5	6
289	B:B:I232	B:B:V200	4.61	Yes	Yes	2	8	6
290	B:B:F234	B:B:V200	9.18	No	Yes	2	5	6
291	B:B:F241	B:B:V200	6.55	Yes	Yes	2	6	6
292	B:B:S201	B:B:W211	6.18	No	Yes	6	9	8
293	B:B:G202	B:B:I229	3.53	No	No	0	6	7
294	B:B:A203	B:B:D205	3.09	No	Yes	6	8	9
295	B:B:C204	B:B:D228	9.34	Yes	No	1	7	9
296	A:A:K210	B:B:C204	4.85	Yes	Yes	1	9	7
297	B:B:D205	B:B:S207	5.89	Yes	No	0	9	5
298	B:B:A208	B:B:F222	2.77	No	Yes	2	6	8
299	B:B:A208	B:B:F241	2.77	No	Yes	2	6	6
300	B:B:K209	B:B:W211	9.28	Yes	Yes	6	6	8
301	B:B:C218	B:B:K209	6.47	Yes	Yes	6	5	6
302	B:B:K209	B:B:T221	4.5	Yes	No	0	6	7
303	B:B:L210	B:B:R219	2.43	Yes	No	0	5	5
304	B:B:L210	B:B:Q220	3.99	Yes	Yes	0	5	7
305	B:B:C218	B:B:W211	5.22	Yes	Yes	6	5	8
306	B:B:D212	B:B:R214	2.38	Yes	No	0	9	9
307	B:B:D212	B:B:E215	12.99	Yes	Yes	6	9	3
308	B:B:D212	B:B:R219	9.53	Yes	No	6	9	5
309	B:B:R214	B:B:V213	2.62	No	No	0	9	4
310	B:B:E215	B:B:G216	3.27	Yes	No	6	3	4
311	B:B:E215	B:B:M217	6.77	Yes	No	0	3	3
312	B:B:E215	B:B:R219	13.96	Yes	No	6	3	5
313	B:B:M217	G:G:Q18	5.44	No	Yes	0	3	9
314	B:B:C218	G:G:Q18	3.05	Yes	Yes	6	5	9
315	B:B:C218	G:G:E22	3.04	Yes	Yes	6	5	9
316	B:B:F222	B:B:Q220	8.2	Yes	Yes	0	8	7
317	B:B:D258	B:B:Q220	5.22	No	Yes	0	7	7
318	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
319	B:B:T221	G:G:E22	7.06	No	Yes	0	7	9
320	B:B:F222	B:B:F241	10.72	Yes	Yes	2	8	6
321	B:B:F222	B:B:F253	6.43	Yes	Yes	2	8	6
322	B:B:G224	B:B:T223	1.82	No	No	0	6	2
323	B:B:H225	B:B:I229	6.63	Yes	No	2	9	7
324	B:B:H225	B:B:T243	6.85	Yes	Yes	2	9	8
325	B:B:H225	B:B:S245	13.95	Yes	No	2	9	9
326	B:B:D247	B:B:H225	2.52	Yes	Yes	2	9	9
327	B:B:H225	B:B:T249	2.74	Yes	Yes	2	9	6
328	B:B:H225	B:B:R251	22.57	Yes	Yes	2	9	8
329	B:B:F253	B:B:H225	3.39	Yes	Yes	2	6	9
330	B:B:D247	B:B:E226	7.8	Yes	No	0	9	3
331	B:B:D247	B:B:S227	4.42	Yes	No	0	9	6
332	B:B:D228	B:B:D246	5.32	No	No	0	9	9
333	A:A:K210	B:B:D228	9.68	Yes	No	1	9	9
334	B:B:I229	B:B:T243	3.04	No	Yes	2	7	8
335	B:B:D246	B:B:N230	5.39	No	No	0	9	9
336	A:A:K210	B:B:N230	2.8	Yes	No	0	9	9
337	B:B:A231	B:B:V276	3.39	No	No	0	5	6
338	B:B:F241	B:B:I232	5.02	Yes	Yes	2	6	8
339	B:B:I232	B:B:T243	3.04	Yes	Yes	2	8	8
340	B:B:F235	B:B:P236	10.11	Yes	Yes	15	6	7
341	B:B:F235	B:B:N237	2.42	Yes	No	15	6	5
342	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
343	B:B:F235	B:B:F278	6.43	Yes	Yes	15	6	7
344	B:B:F235	B:B:G282	4.52	Yes	No	15	6	9
345	B:B:F235	G:G:L37	7.31	Yes	No	0	6	7
346	B:B:F235	G:G:Y40	5.16	Yes	Yes	15	6	6
347	B:B:F278	B:B:P236	2.89	Yes	Yes	15	7	7
348	B:B:G282	B:B:P236	4.06	No	Yes	15	9	7
349	B:B:P236	G:G:Y40	4.17	Yes	Yes	15	7	6
350	B:B:N237	G:G:Y40	12.79	No	Yes	15	5	6
351	B:B:N239	B:B:R256	3.62	No	No	0	2	9
352	B:B:F241	B:B:T243	2.59	Yes	Yes	2	6	8
353	B:B:F241	B:B:F253	12.86	Yes	Yes	2	6	6
354	B:B:F241	B:B:L255	2.44	Yes	No	0	6	6
355	B:B:A242	B:B:F278	2.77	No	Yes	0	4	7
356	B:B:G244	B:B:T243	1.82	Yes	Yes	2	5	8
357	B:B:F253	B:B:T243	7.78	Yes	Yes	2	6	8
358	B:B:C250	B:B:G244	1.96	Yes	Yes	2	8	5
359	B:B:G244	B:B:I273	3.53	Yes	Yes	2	5	6
360	B:B:G244	B:B:V276	1.84	Yes	No	0	5	6
361	B:B:D247	B:B:S245	8.83	Yes	No	2	9	9
362	B:B:D247	B:B:T249	7.23	Yes	Yes	2	9	6
363	B:B:R251	B:B:T249	10.35	Yes	Yes	2	8	6
364	B:B:S265	B:B:T249	3.2	No	Yes	0	2	6
365	B:B:C250	B:B:Y264	2.69	Yes	Yes	2	8	5
366	B:B:C250	B:B:I273	4.91	Yes	Yes	2	8	6
367	B:B:A287	B:B:C250	1.81	No	Yes	2	6	8
368	B:B:F253	B:B:R251	3.21	Yes	Yes	2	6	8
369	B:B:E260	B:B:R251	11.63	No	Yes	2	6	8
370	B:B:R251	B:B:T263	3.88	Yes	No	2	8	1
371	B:B:L252	B:B:L261	8.3	No	No	0	7	5
372	B:B:E260	B:B:F253	2.33	No	Yes	2	6	6
373	B:B:D254	B:B:L261	12.21	No	No	0	9	5
374	B:B:D254	G:G:A33	4.63	No	No	0	9	7
375	B:B:R256	G:G:I28	8.77	No	No	0	9	4
376	B:B:R256	G:G:D36	5.96	No	No	0	9	5
377	B:B:D258	G:G:R27	11.91	No	No	21	7	8
378	B:B:E260	B:B:T263	2.82	No	No	2	6	1
379	B:B:M262	B:B:Y264	7.18	Yes	Yes	2	4	5
380	B:B:A302	B:B:M262	4.83	No	Yes	2	2	4
381	B:B:S265	B:B:T263	3.2	No	No	0	2	1
382	B:B:L285	B:B:Y264	2.34	Yes	Yes	0	6	5
383	B:B:W297	B:B:Y264	4.82	Yes	Yes	2	8	5
384	B:B:A302	B:B:Y264	2.67	No	Yes	2	2	5
385	B:B:H266	B:B:N268	3.83	Yes	No	0	4	4
386	B:B:H266	B:B:I269	2.65	Yes	Yes	0	4	4
387	B:B:H266	B:B:R304	5.64	Yes	Yes	0	4	5
388	B:B:I269	B:B:Y289	4.84	Yes	Yes	2	4	7
389	B:B:I269	B:B:W297	2.35	Yes	Yes	2	4	8
390	B:B:C271	B:B:G272	1.96	No	No	2	5	4
391	B:B:C271	B:B:D290	7.78	No	No	2	5	6
392	B:B:C271	B:B:D291	4.67	No	No	0	5	8
393	B:B:G272	B:B:I273	1.76	No	Yes	2	4	6
394	B:B:D290	B:B:G272	3.35	No	No	2	6	4
395	B:B:I273	B:B:Y289	7.25	Yes	Yes	2	6	7
396	B:B:S275	B:B:T274	4.8	No	No	0	8	8
397	B:B:G288	B:B:T274	1.82	No	No	0	7	8
398	B:B:R314	B:B:T274	2.59	No	No	0	8	8
399	B:B:L318	B:B:S275	3	Yes	No	0	6	8
400	B:B:L285	B:B:V276	2.98	Yes	No	0	6	6
401	B:B:L318	B:B:S277	3	Yes	No	0	6	5
402	B:B:G319	B:B:S277	1.86	No	No	0	5	5
403	B:B:S277	B:B:V320	4.85	No	No	0	5	7
404	B:B:F278	B:B:L285	4.87	Yes	Yes	0	7	6
405	B:B:G282	B:B:S279	1.86	No	No	0	9	9
406	B:B:L284	B:B:S279	4.5	No	No	0	5	9
407	B:B:S279	G:G:D48	2.94	No	No	0	9	9
408	B:B:G324	B:B:K280	1.74	No	No	0	9	1
409	B:B:K280	G:G:E47	2.7	No	No	0	1	3
410	B:B:S281	G:G:D48	11.78	No	No	0	9	9
411	B:B:D298	B:B:R283	10.72	No	No	0	9	9
412	B:B:R283	G:G:L51	7.29	No	Yes	0	9	6
413	B:B:L284	B:B:V296	2.98	No	No	0	5	5
414	B:B:L284	G:G:L51	2.77	No	Yes	0	5	6
415	B:B:L286	B:B:V296	4.47	No	No	0	7	5
416	B:B:L286	B:B:L318	4.15	No	Yes	0	7	6
417	B:B:L286	B:B:V327	4.47	No	No	0	7	6
418	B:B:A287	B:B:Y289	5.34	No	Yes	2	6	7
419	B:B:A287	B:B:W297	2.59	No	Yes	2	6	8
420	B:B:G288	B:B:V315	3.68	No	No	0	7	7
421	B:B:D291	B:B:Y289	4.6	No	Yes	0	8	7
422	B:B:N295	B:B:Y289	8.14	Yes	Yes	2	6	7
423	B:B:W297	B:B:Y289	2.89	Yes	Yes	2	8	7
424	B:B:D290	B:B:R314	13.1	No	No	0	6	8
425	B:B:D291	B:B:N293	10.77	No	Yes	0	8	5
426	B:B:F292	B:B:N313	4.83	No	No	0	4	7
427	B:B:N293	B:B:N295	2.72	Yes	Yes	0	5	6
428	B:B:N293	B:B:V307	2.96	Yes	No	0	5	3
429	B:B:A309	B:B:N293	3.13	No	Yes	0	3	5
430	B:B:C294	B:B:L308	6.35	No	No	0	5	7
431	B:B:C294	B:B:L318	3.17	No	Yes	0	5	6
432	B:B:N295	B:B:W297	6.78	Yes	Yes	2	6	8
433	B:B:N295	B:B:R304	15.67	Yes	Yes	2	6	5
434	B:B:G306	B:B:V296	1.84	No	No	0	4	5
435	B:B:R304	B:B:W297	3	Yes	Yes	2	5	8
436	B:B:D298	B:B:K301	5.53	No	Yes	22	9	5
437	B:B:D298	B:B:D303	3.99	No	No	22	9	2
438	B:B:L300	G:G:C41	4.76	No	No	0	6	7
439	B:B:D303	B:B:K301	5.53	No	Yes	22	2	5
440	B:B:R304	B:B:V307	2.62	Yes	No	0	5	3
441	B:B:L308	B:B:W339	21.64	No	Yes	10	7	9
442	B:B:H311	B:B:V315	4.15	Yes	No	0	9	7
443	B:B:H311	B:B:T329	6.85	Yes	No	0	9	8
444	B:B:H311	B:B:S331	13.95	Yes	No	10	9	9
445	B:B:D333	B:B:H311	8.82	Yes	Yes	10	9	9
446	B:B:H311	B:B:K337	3.93	Yes	Yes	10	9	6
447	B:B:D312	B:B:D333	3.99	No	Yes	0	5	9
448	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
449	B:B:R314	B:B:W332	20.99	No	Yes	0	8	9
450	B:B:C317	B:B:S316	3.44	No	No	0	7	9
451	B:B:S316	B:B:W332	3.71	No	Yes	0	9	9
452	B:B:C317	B:B:G330	1.96	No	No	0	7	5
453	B:B:L318	B:B:T329	2.95	Yes	No	0	6	8
454	B:B:D323	B:B:T321	5.78	No	Yes	5	7	7
455	B:B:G324	B:B:T321	1.82	No	Yes	0	9	7
456	B:B:D323	B:B:M325	9.7	No	No	0	7	5
457	B:B:G324	G:G:P49	4.06	No	No	0	9	7
458	B:B:M325	G:G:P49	5.03	No	No	0	5	7
459	B:B:A326	B:B:N340	4.69	No	No	5	7	9
460	B:B:A326	G:G:F61	4.16	No	Yes	5	7	8
461	B:B:T329	B:B:W339	7.28	No	Yes	0	8	9
462	B:B:G330	B:B:L336	3.42	No	Yes	5	5	7
463	B:B:D333	B:B:S331	11.78	Yes	No	10	9	9
464	A:A:H213	B:B:W332	4.23	Yes	Yes	1	8	9
465	B:B:D333	B:B:F335	8.36	Yes	No	0	9	4
466	B:B:K337	B:B:W339	8.12	Yes	Yes	10	6	9
467	B:B:I338	G:G:F61	3.77	No	Yes	5	5	8
468	B:B:N340	G:G:F61	13.29	No	Yes	5	9	8
469	G:G:I9	G:G:T6	3.04	No	No	0	2	3
470	G:G:A7	G:G:Q11	3.03	No	No	0	4	3
471	G:G:I9	G:G:R13	11.27	No	No	0	2	6
472	G:G:L15	G:G:L19	2.77	No	Yes	20	2	9
473	G:G:M21	G:G:Q18	9.52	No	Yes	6	1	9
474	G:G:E22	G:G:Q18	12.74	Yes	Yes	6	9	9
475	G:G:E22	G:G:M21	4.06	Yes	No	6	9	1
476	G:G:H44	G:G:Y40	13.07	No	Yes	0	6	6
477	G:G:D48	G:G:L51	10.86	No	Yes	0	9	6
478	G:G:P49	G:G:V54	3.53	No	Yes	0	7	6
479	G:G:P53	G:G:T52	1.75	No	No	0	8	4
480	G:G:P55	G:G:V54	5.3	No	Yes	17	5	6
481	G:G:E58	G:G:V54	5.7	No	Yes	17	5	6
482	G:G:N59	G:G:V54	4.43	No	Yes	0	9	6
483	G:G:P55	G:G:S57	3.56	No	No	17	5	6
484	G:G:E58	G:G:P55	12.58	No	No	17	5	5
485	G:G:E58	G:G:S57	7.19	No	No	17	5	6
486	G:G:N59	G:G:R62	9.64	No	No	0	9	7
487	G:G:F61	G:G:P60	2.89	Yes	No	5	8	9
488	A:A:G2	A:A:K10	3.49	No	No	0	6	3
489	A:A:D9	A:A:L5	6.79	No	No	0	4	2
490	A:A:K10	A:A:L5	5.64	No	No	0	3	2
491	A:A:K17	A:A:V13	3.04	No	No	0	4	3
492	A:A:R21	A:A:R24	4.26	No	No	0	4	3
493	A:A:E25	A:A:R21	5.82	No	No	0	4	4
494	A:A:K29	A:A:R32	2.48	No	No	0	1	4
495	A:A:R32	R:R:K138	6.19	No	No	0	4	4
496	A:A:E33	A:A:K197	16.2	No	Yes	0	6	6
497	A:A:L36	A:A:V34	2.98	No	Yes	0	7	5
498	A:A:L194	A:A:V34	4.47	Yes	Yes	7	4	5
499	A:A:F196	A:A:V34	9.18	Yes	Yes	7	7	5
500	A:A:T219	A:A:V34	4.76	No	Yes	0	7	5
501	A:A:V339	A:A:V34	4.81	No	Yes	7	8	5
502	A:A:F199	A:A:K35	7.44	Yes	No	0	5	9
503	A:A:K35	A:A:V218	4.55	No	No	0	9	9
504	A:A:L36	A:A:M198	2.83	No	No	0	7	7
505	A:A:I222	A:A:L36	4.28	No	No	0	7	7
506	A:A:L37	A:A:L39	5.54	No	Yes	0	9	9
507	A:A:F215	A:A:L37	7.31	Yes	No	0	9	9
508	A:A:I221	A:A:L37	2.85	No	No	0	8	9
509	A:A:K46	A:A:L38	4.23	Yes	No	25	9	8
510	A:A:D200	A:A:L38	4.07	No	No	25	9	8
511	A:A:I222	A:A:L38	2.85	No	No	0	7	8
512	A:A:F223	A:A:L39	4.87	Yes	Yes	3	9	9
513	A:A:I253	A:A:L39	5.71	No	Yes	3	8	9
514	A:A:G40	A:A:S44	1.86	No	No	0	9	9
515	A:A:G40	A:A:K46	6.97	No	Yes	0	9	9
516	A:A:E43	A:A:R242	6.98	No	Yes	0	9	9
517	A:A:G45	A:A:T48	1.82	No	No	0	9	9
518	A:A:G45	A:A:N269	3.39	No	No	0	9	9
519	A:A:D200	A:A:K46	4.15	No	Yes	25	9	9
520	A:A:G202	A:A:K46	1.74	No	Yes	0	9	9
521	A:A:C224	A:A:K46	3.23	No	Yes	0	7	9
522	A:A:C224	A:A:I49	3.27	No	Yes	0	7	7
523	A:A:F267	A:A:I49	6.28	Yes	Yes	11	9	7
524	A:A:I49	A:A:N331	5.66	Yes	Yes	11	7	8
525	A:A:K51	A:A:K54	4.31	No	No	0	9	7
526	A:A:N331	A:A:Q52	10.56	Yes	No	0	8	9
527	A:A:F189	A:A:M53	2.49	No	No	7	9	8
528	A:A:M198	A:A:M53	2.89	No	No	7	7	8
529	A:A:M53	A:A:V332	6.09	No	No	0	8	7
530	A:A:H188	A:A:I55	2.65	No	No	0	3	8
531	A:A:I184	A:A:V201	4.61	No	No	1	9	9
532	A:A:F215	A:A:I184	2.51	Yes	No	1	9	9
533	A:A:E186	A:A:K197	2.7	No	Yes	1	9	6
534	A:A:E186	A:A:F199	10.49	No	Yes	1	9	5
535	A:A:F189	A:A:F196	13.93	No	Yes	7	9	7
536	A:A:F189	A:A:M198	4.98	No	No	7	9	7
537	A:A:H195	A:A:T190	4.11	No	No	0	4	3
538	A:A:F191	A:A:K192	8.69	No	No	7	5	4
539	A:A:F191	A:A:V332	9.18	No	No	0	5	7
540	A:A:F191	A:A:F336	3.22	No	Yes	7	5	8
541	A:A:K192	A:A:Q333	5.42	No	No	7	4	5
542	A:A:F336	A:A:K192	14.89	Yes	No	7	8	4
543	A:A:F196	A:A:L194	7.31	Yes	Yes	7	7	4
544	A:A:F336	A:A:L194	3.65	Yes	Yes	7	8	4
545	A:A:L194	R:R:H133	5.14	Yes	Yes	0	4	6
546	A:A:F196	A:A:F336	2.14	Yes	Yes	7	7	8
547	A:A:F196	A:A:V339	3.93	Yes	No	7	7	8
548	A:A:F199	A:A:K197	2.48	Yes	Yes	1	5	6
549	A:A:F199	A:A:F215	4.29	Yes	Yes	1	5	9
550	A:A:V201	A:A:W211	7.36	No	Yes	1	9	9
551	A:A:F215	A:A:V201	2.62	Yes	No	1	9	9
552	A:A:Q204	A:A:S206	4.33	No	No	1	9	8
553	A:A:Q204	A:A:W211	6.57	No	Yes	1	9	9
554	A:A:E207	A:A:K210	8.1	No	Yes	0	9	9
555	A:A:R208	A:A:W211	4	Yes	Yes	0	9	9
556	A:A:I212	A:A:R208	6.26	No	Yes	0	8	9
557	A:A:L249	A:A:R208	3.64	No	Yes	0	9	9
558	A:A:F215	A:A:W211	2	Yes	Yes	1	9	9
559	A:A:I212	A:A:W258	2.35	No	Yes	0	8	5
560	A:A:F259	A:A:I212	5.02	Yes	No	0	9	8
561	A:A:C214	A:A:H213	2.95	Yes	Yes	1	7	8
562	A:A:H213	A:A:W258	11.64	Yes	Yes	1	8	5
563	A:A:C214	A:A:F215	2.79	Yes	Yes	1	7	9
564	A:A:F215	A:A:V218	2.62	Yes	No	0	9	9
565	A:A:E216	A:A:W258	6.54	No	Yes	0	7	5
566	A:A:T219	A:A:V342	3.17	No	No	0	7	7
567	A:A:F259	A:A:I221	8.79	Yes	No	3	9	8
568	A:A:I221	A:A:T262	3.04	No	No	3	8	7
569	A:A:F267	A:A:I222	2.51	Yes	No	0	9	7
570	A:A:F223	A:A:V225	2.62	Yes	Yes	3	9	7
571	A:A:F223	A:A:L249	6.09	Yes	No	0	9	9
572	A:A:F223	A:A:F250	10.72	Yes	Yes	3	9	9
573	A:A:F223	A:A:I253	2.51	Yes	No	3	9	8
574	A:A:F223	A:A:L266	2.44	Yes	Yes	3	9	9
575	A:A:S246	A:A:V225	4.85	No	Yes	0	9	7
576	A:A:L268	A:A:V225	2.98	Yes	Yes	3	8	7
577	A:A:F307	A:A:V225	7.87	Yes	Yes	3	8	7
578	A:A:A226	A:A:K270	3.21	No	No	0	8	9
579	A:A:L227	A:A:L268	6.92	No	Yes	3	7	8
580	A:A:F274	A:A:L227	6.09	Yes	No	3	9	7
581	A:A:F323	A:A:L227	2.44	Yes	No	3	4	7
582	A:A:K270	A:A:S228	3.06	No	No	0	9	9
583	A:A:L273	A:A:S228	6.01	No	No	0	6	9
584	A:A:D229	A:A:L232	10.86	No	No	3	8	8
585	A:A:D229	A:A:R242	9.53	No	Yes	3	8	9
586	A:A:D231	A:A:Y230	24.14	No	Yes	3	9	8
587	A:A:F274	A:A:Y230	5.16	Yes	Yes	3	9	8
588	A:A:K277	A:A:Y230	2.39	No	Yes	3	9	8
589	A:A:I278	A:A:Y230	4.84	Yes	Yes	3	6	8
590	A:A:S281	A:A:Y230	2.54	Yes	Yes	3	7	8
591	A:A:L283	A:A:Y230	2.34	Yes	Yes	3	7	8
592	A:A:D231	A:A:K277	12.44	No	No	3	9	9
593	A:A:D231	A:A:S281	7.36	No	Yes	3	9	7
594	A:A:L232	A:A:R242	14.58	No	Yes	3	8	9
595	A:A:K277	A:A:L232	2.82	No	No	3	9	8
596	A:A:L234	A:A:R242	3.64	No	Yes	0	8	9
597	A:A:A235	A:A:E236	3.02	No	No	0	4	9
598	A:A:H244	A:A:M240	5.25	Yes	No	0	4	6
599	A:A:H244	A:A:N241	12.75	Yes	No	26	4	9
600	A:A:C286	A:A:N241	7.87	No	No	26	6	9
601	A:A:M243	A:A:Y287	4.79	No	Yes	0	8	7
602	A:A:H244	A:A:M247	3.94	Yes	No	0	4	6
603	A:A:C286	A:A:H244	5.9	No	Yes	26	6	4
604	A:A:M247	A:A:Y287	2.39	No	Yes	0	6	7
605	A:A:F307	A:A:M247	4.98	Yes	No	0	8	6
606	A:A:C254	A:A:F250	4.19	Yes	Yes	3	5	9
607	A:A:F250	A:A:I264	3.77	Yes	No	3	9	6
608	A:A:F250	A:A:L266	3.65	Yes	Yes	3	9	9
609	A:A:F250	A:A:L310	2.44	Yes	No	0	9	4
610	A:A:F250	A:A:I319	5.02	Yes	No	0	9	5
611	A:A:D251	A:A:N255	4.04	No	No	3	5	8
612	A:A:D251	A:A:L310	10.86	No	No	0	5	4
613	A:A:D251	A:A:K312	6.91	No	No	3	5	5
614	A:A:F259	A:A:I253	5.02	Yes	No	3	9	8
615	A:A:C254	A:A:I264	3.27	Yes	No	3	5	6
616	A:A:C254	A:A:N311	4.72	Yes	Yes	3	5	8
617	A:A:C254	A:A:K317	3.23	Yes	Yes	3	5	7
618	A:A:K312	A:A:N255	15.39	No	No	3	5	8
619	A:A:N255	A:A:R313	6.03	No	Yes	3	8	4
620	A:A:K257	A:A:N256	2.8	No	No	1	4	8
621	A:A:N256	A:A:W258	4.52	No	Yes	1	8	5
622	A:A:K257	A:A:W258	15.08	No	Yes	1	4	5
623	A:A:F259	A:A:T262	7.78	Yes	No	3	9	7
624	A:A:D261	A:A:T260	7.23	No	No	0	4	3
625	A:A:R313	A:A:T260	5.17	Yes	No	0	4	3
626	A:A:D261	A:A:T316	4.34	No	No	0	4	3
627	A:A:S263	A:A:V342	3.23	No	No	0	7	7
628	A:A:I264	A:A:K317	4.36	No	Yes	3	6	7
629	A:A:F267	A:A:I265	2.51	Yes	Yes	11	9	8
630	A:A:F334	A:A:I265	2.51	Yes	Yes	11	3	8
631	A:A:A338	A:A:I265	3.25	No	Yes	0	6	8
632	A:A:F307	A:A:L266	2.44	Yes	Yes	3	8	9
633	A:A:L266	A:A:T321	8.84	Yes	Yes	3	9	5
634	A:A:F267	A:A:H322	6.79	Yes	Yes	11	9	9
635	A:A:F267	A:A:T324	5.19	Yes	Yes	11	9	9
636	A:A:F267	A:A:N331	7.25	Yes	Yes	11	9	8
637	A:A:F267	A:A:F334	2.14	Yes	Yes	11	9	3
638	A:A:F267	A:A:V335	2.62	Yes	No	0	9	8
639	A:A:F307	A:A:L268	2.44	Yes	Yes	3	8	8
640	A:A:L268	A:A:T321	2.95	Yes	Yes	3	8	5
641	A:A:F323	A:A:L268	7.31	Yes	Yes	3	4	8
642	A:A:N269	A:A:T324	4.39	No	Yes	0	9	9
643	A:A:K271	A:A:Y296	11.94	No	No	0	5	4
644	A:A:F323	A:A:K271	8.69	Yes	No	0	4	5
645	A:A:C325	A:A:K271	9.7	No	No	0	7	5
646	A:A:C325	A:A:D272	9.34	No	No	0	7	9
647	A:A:F274	A:A:I278	3.77	Yes	Yes	3	9	6
648	A:A:F274	A:A:Y296	6.19	Yes	No	0	9	4
649	A:A:A299	A:A:F274	2.77	No	Yes	0	7	9
650	A:A:F274	A:A:I303	2.51	Yes	No	0	9	7
651	A:A:E275	A:A:Y296	5.61	No	No	0	5	4
652	A:A:I278	A:A:L283	4.28	Yes	Yes	3	6	7
653	A:A:P282	A:A:S281	3.56	No	Yes	0	5	7
654	A:A:I285	A:A:S281	3.1	No	Yes	0	3	7
655	A:A:P282	A:A:T284	6.99	No	No	0	5	4
656	A:A:N294	A:A:P282	6.52	No	No	0	3	5
657	A:A:L283	A:A:Y290	7.03	Yes	Yes	0	7	7
658	A:A:L283	A:A:N294	2.75	Yes	No	0	7	3
659	A:A:A299	A:A:L283	3.15	No	Yes	0	7	7
660	A:A:C286	A:A:Y287	5.38	No	Yes	0	6	7
661	A:A:Y287	A:A:Y302	4.96	Yes	No	0	7	6
662	A:A:I303	A:A:Y287	3.63	No	Yes	0	7	7
663	A:A:G292	A:A:Y290	5.79	No	Yes	0	7	7
664	A:A:E298	A:A:Y290	6.73	No	Yes	0	4	7
665	A:A:Y290	A:A:Y302	16.88	Yes	No	0	7	6
666	A:A:E298	A:A:S293	2.87	No	No	0	4	3
667	A:A:E297	A:A:T295	2.82	No	No	0	4	5
668	A:A:E298	A:A:T295	11.29	No	No	0	4	5
669	A:A:A300	A:A:F323	2.77	No	Yes	0	5	4
670	A:A:Q306	A:A:Y302	3.38	No	No	0	5	6
671	A:A:F307	A:A:I303	2.51	Yes	No	0	8	7
672	A:A:E308	A:A:Q304	5.1	No	No	3	3	5
673	A:A:Q304	A:A:T321	11.34	No	Yes	3	5	5
674	A:A:F323	A:A:Q304	3.51	Yes	No	3	4	5
675	A:A:E308	A:A:I319	6.83	No	No	0	3	5
676	A:A:E308	A:A:T321	5.64	No	Yes	3	3	5
677	A:A:N311	A:A:R313	2.41	Yes	Yes	3	8	4
678	A:A:K317	A:A:N311	2.8	Yes	Yes	3	7	8
679	A:A:I319	A:A:N311	5.66	No	Yes	0	5	8
680	A:A:K317	A:A:R313	4.95	Yes	Yes	3	7	4
681	A:A:D315	R:R:K225	2.77	No	No	0	3	5
682	A:A:E318	A:A:Y320	8.98	No	No	0	4	7
683	A:A:E318	A:A:K345	4.05	No	No	0	4	5
684	A:A:E318	R:R:H223	3.69	No	No	0	4	4
685	A:A:F334	A:A:Y320	2.06	Yes	No	0	3	7
686	A:A:A338	A:A:Y320	5.34	No	No	0	6	7
687	A:A:H322	A:A:T324	2.74	Yes	Yes	11	9	9
688	A:A:H322	A:A:K330	2.62	Yes	No	0	9	4
689	A:A:H322	A:A:N331	3.83	Yes	Yes	11	9	8
690	A:A:F334	A:A:H322	12.44	Yes	Yes	11	3	9
691	A:A:T324	A:A:T327	4.71	Yes	No	11	9	8
692	A:A:N331	A:A:T324	8.77	Yes	Yes	11	8	9
693	A:A:K330	A:A:T327	4.5	No	No	0	4	8
694	A:A:N331	A:A:T327	4.39	Yes	No	11	8	8
695	A:A:F336	A:A:Q333	2.34	Yes	No	7	8	5
696	A:A:D337	A:A:Q333	11.75	No	No	0	4	5
697	A:A:F336	A:A:T340	6.49	Yes	Yes	7	8	6
698	A:A:I343	A:A:V339	3.07	No	No	0	7	8
699	A:A:D341	A:A:T340	2.89	No	Yes	7	8	6
700	A:A:I344	A:A:T340	3.04	Yes	Yes	7	6	6
701	A:A:T340	R:R:H133	5.48	Yes	Yes	0	6	6
702	A:A:T340	R:R:R218	5.17	Yes	Yes	7	6	5
703	A:A:D341	R:R:R218	3.57	No	Yes	7	8	5
704	A:A:D341	R:R:M220	5.54	No	Yes	7	8	3
705	A:A:N346	A:A:V342	4.43	No	No	0	4	7
706	A:A:I343	A:A:N347	4.25	No	No	0	7	8
707	A:A:I343	R:R:H133	7.95	No	Yes	0	7	6
708	A:A:I344	R:R:P132	5.08	Yes	No	0	6	8
709	A:A:I344	R:R:R218	3.76	Yes	Yes	7	6	5
710	A:A:I344	R:R:M220	5.83	Yes	Yes	7	6	3
711	A:A:K345	R:R:M220	5.76	No	Yes	0	5	3
712	A:A:N347	R:R:R128	3.62	No	Yes	9	8	8
713	A:A:N347	R:R:N137	2.72	No	No	9	8	4
714	A:A:L348	A:A:L353	4.15	No	Yes	0	9	7
715	A:A:F354	A:A:L348	9.74	Yes	No	27	5	9
716	A:A:L348	R:R:I226	2.85	No	Yes	27	9	6
717	A:A:F354	A:A:K349	7.44	Yes	No	0	5	5
718	A:A:D350	R:R:K60	5.53	No	No	0	4	7
719	A:A:D350	R:R:R128	3.57	No	Yes	0	4	8
720	A:A:L353	R:R:R125	7.29	Yes	No	0	7	9
721	A:A:L353	R:R:I233	2.85	Yes	Yes	0	7	7
722	A:A:F354	R:R:K225	6.2	Yes	No	0	5	5
723	A:A:F354	R:R:I226	6.28	Yes	Yes	27	5	6
724	R:R:F10	R:R:F21	7.5	No	Yes	4	7	2
725	R:R:F10	R:R:R270	2.14	No	No	4	7	1
726	R:R:D14	R:R:E12	9.09	No	Yes	0	5	5
727	R:R:E12	R:R:V20	2.85	Yes	No	18	5	2
728	R:R:E12	R:R:N171	5.26	Yes	Yes	18	5	1
729	R:R:E12	R:R:L176	3.98	Yes	Yes	18	5	4
730	R:R:I13	R:R:N17	2.83	No	No	0	3	5
731	R:R:D14	R:R:I169	11.2	No	No	0	5	1
732	R:R:K15	R:R:K165	5.75	No	No	0	3	4
733	R:R:K16	R:R:T185	13.51	No	No	0	4	2
734	R:R:C18	R:R:C183	7.28	No	No	0	9	1
735	R:R:C19	R:R:F21	2.79	No	Yes	4	4	2
736	R:R:C19	R:R:C266	7.28	No	No	4	4	7
737	R:R:N171	R:R:V20	2.96	Yes	No	18	1	2
738	R:R:L176	R:R:V20	4.47	Yes	No	18	4	2
739	R:R:C266	R:R:F21	2.79	No	Yes	4	7	2
740	R:R:F21	R:R:Y269	2.06	Yes	Yes	4	2	2
741	R:R:F21	R:R:R270	14.97	Yes	No	4	2	1
742	R:R:D273	R:R:F21	5.97	No	Yes	0	4	2
743	R:R:N171	R:R:R22	2.41	Yes	No	0	1	3
744	R:R:A174	R:R:R22	4.15	No	No	0	2	3
745	R:R:D23	R:R:R270	19.06	No	No	0	4	1
746	R:R:D24	R:R:V27	2.92	No	No	0	4	3
747	R:R:D24	R:R:R90	3.57	No	No	0	4	4
748	R:R:F25	R:R:K28	7.44	No	No	0	6	3
749	R:R:F25	R:R:V29	5.24	No	No	0	6	5
750	R:R:F25	R:R:L274	12.18	No	No	0	6	1
751	R:R:I26	R:R:L30	4.28	No	Yes	0	5	5
752	R:R:I26	R:R:Y87	6.04	No	Yes	0	5	6
753	R:R:I26	R:R:L274	2.85	No	No	0	5	1
754	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
755	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
756	R:R:P31	R:R:P32	7.79	No	No	0	6	5
757	R:R:P31	R:R:V88	3.53	No	No	0	6	3
758	R:R:E37	R:R:V33	2.85	Yes	No	4	7	5
759	R:R:S281	R:R:V33	4.85	No	No	4	6	5
760	R:R:L34	R:R:L80	2.77	No	No	0	8	8
761	R:R:G35	R:R:M84	1.75	No	No	0	5	7
762	R:R:F40	R:R:L36	3.65	No	No	0	6	4
763	R:R:E37	R:R:S281	5.75	Yes	No	4	7	6
764	R:R:E37	R:R:Y284	4.49	Yes	Yes	4	7	7
765	R:R:E37	R:R:M288	4.06	Yes	No	0	7	8
766	R:R:F38	R:R:L42	2.44	Yes	No	29	7	7
767	R:R:F38	R:R:I77	2.51	Yes	No	29	7	6
768	R:R:F38	R:R:L80	2.44	Yes	No	0	7	8
769	R:R:F38	R:R:P81	10.11	Yes	No	0	7	8
770	R:R:F40	R:R:I39	5.02	No	No	0	6	5
771	R:R:G41	R:R:I77	1.76	No	No	0	8	6
772	R:R:G41	R:R:M288	1.75	No	No	0	8	8
773	R:R:I77	R:R:L42	2.85	No	No	29	6	7
774	R:R:G44	R:R:L43	5.13	No	No	0	7	4
775	R:R:G44	R:R:P291	2.03	No	Yes	0	7	9
776	R:R:D73	R:R:N45	14.81	No	No	0	9	9
777	R:R:F74	R:R:N45	2.42	No	No	0	7	9
778	R:R:N45	R:R:P291	8.15	No	Yes	0	9	9
779	R:R:I51	R:R:L47	2.85	No	No	0	7	6
780	R:R:F296	R:R:L47	2.44	No	No	0	8	6
781	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
782	R:R:F67	R:R:L49	3.65	No	No	0	6	7
783	R:R:F74	R:R:L49	3.65	No	No	0	7	7
784	R:R:F54	R:R:W50	8.02	No	No	30	4	4
785	R:R:H55	R:R:W50	6.35	No	No	30	5	4
786	R:R:F52	R:R:L56	3.65	Yes	Yes	12	7	5
787	R:R:F52	R:R:R63	4.28	Yes	No	12	7	7
788	R:R:F52	R:R:L66	2.44	Yes	No	12	7	8
789	R:R:F52	R:R:F67	2.14	Yes	No	0	7	6
790	R:R:F52	R:R:Y295	8.25	Yes	Yes	12	7	7
791	R:R:C53	R:R:F54	5.59	No	No	0	4	4
792	R:R:F54	R:R:H55	2.26	No	No	30	4	5
793	R:R:L56	R:R:W59	4.56	Yes	No	0	5	6
794	R:R:L56	R:R:R63	4.86	Yes	No	12	5	7
795	R:R:I64	R:R:W59	2.35	No	No	0	7	6
796	R:R:I139	R:R:S61	7.74	No	No	0	7	6
797	R:R:D124	R:R:S62	5.89	No	No	0	8	8
798	R:R:A144	R:R:I64	3.25	No	No	0	7	7
799	R:R:F65	R:R:V120	7.87	No	No	0	7	7
800	R:R:A144	R:R:F65	2.77	No	No	0	7	7
801	R:R:F65	R:R:S148	2.64	No	No	0	7	8
802	R:R:L66	R:R:V121	2.98	No	No	12	8	9
803	R:R:L66	R:R:Y295	3.52	No	Yes	12	8	7
804	R:R:F117	R:R:N68	13.29	Yes	Yes	16	8	9
805	R:R:N68	R:R:S148	8.94	Yes	No	0	9	8
806	R:R:N68	R:R:W152	5.65	Yes	Yes	16	9	9
807	R:R:L69	R:R:S114	3	Yes	No	0	9	9
808	R:R:F117	R:R:L69	2.44	Yes	Yes	0	8	9
809	R:R:D290	R:R:L69	10.86	Yes	Yes	0	9	9
810	R:R:L69	R:R:Y295	3.52	Yes	Yes	0	9	7
811	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
812	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
813	R:R:D73	R:R:S287	4.42	No	No	0	9	8
814	R:R:D290	R:R:D73	2.66	Yes	No	0	9	9
815	R:R:L75	R:R:N110	10.98	No	Yes	0	6	9
816	R:R:L107	R:R:L76	4.15	No	No	4	6	7
817	R:R:L76	R:R:N110	5.49	No	Yes	0	7	9
818	R:R:L76	R:R:Y284	4.69	No	Yes	4	7	7
819	R:R:C79	R:R:M103	3.24	No	Yes	0	6	5
820	R:R:C79	R:R:M106	3.24	No	No	0	6	5
821	R:R:C79	R:R:L107	4.76	No	No	0	6	6
822	R:R:L80	R:R:Y284	2.34	No	Yes	0	8	7
823	R:R:F82	R:R:W93	2	No	Yes	13	6	9
824	R:R:F82	R:R:F95	4.29	No	No	13	6	7
825	R:R:L83	R:R:Y87	9.38	No	Yes	0	6	6
826	R:R:L83	R:R:M103	2.83	No	Yes	0	6	5
827	R:R:D85	R:R:F95	3.58	No	No	0	4	7
828	R:R:N86	R:R:W91	9.04	No	No	0	5	4
829	R:R:N86	R:R:W93	2.26	No	Yes	0	5	9
830	R:R:W91	R:R:Y87	9.65	No	Yes	28	4	6
831	R:R:F277	R:R:Y87	3.09	No	Yes	28	5	6
832	R:R:D92	R:R:R89	3.57	No	No	0	4	4
833	R:R:F277	R:R:W91	6.01	No	No	28	5	4
834	R:R:D92	R:R:K94	9.68	No	No	0	4	3
835	R:R:A174	R:R:D92	4.63	No	No	0	2	4
836	R:R:F95	R:R:W93	8.02	No	Yes	13	7	9
837	R:R:C100	R:R:W93	6.53	Yes	Yes	13	9	9
838	R:R:M103	R:R:W93	3.49	Yes	Yes	0	5	9
839	R:R:D97	R:R:R101	4.76	No	No	0	3	6
840	R:R:D97	R:R:K166	5.53	No	No	0	3	4
841	R:R:D97	R:R:P168	14.49	No	No	0	3	4
842	R:R:I98	R:R:P99	3.39	No	No	0	2	5
843	R:R:I98	R:R:R101	2.51	No	No	0	2	6
844	R:R:C100	R:R:M167	3.24	Yes	Yes	13	9	3
845	R:R:C100	R:R:P168	7.53	Yes	No	13	9	4
846	R:R:C100	R:R:C177	7.28	Yes	No	13	9	9
847	R:R:L104	R:R:M103	2.83	No	Yes	0	5	5
848	R:R:L104	R:R:M167	4.24	No	Yes	13	5	3
849	R:R:C177	R:R:L104	4.76	No	No	13	9	5
850	R:R:F105	R:R:M109	3.73	No	Yes	16	6	5
851	R:R:F105	R:R:T159	6.49	No	No	16	6	7
852	R:R:F105	R:R:L163	7.31	No	No	0	6	5
853	R:R:M106	R:R:N110	4.21	No	Yes	0	5	9
854	R:R:L107	R:R:Y284	2.34	No	Yes	4	6	7
855	R:R:M109	R:R:N110	5.61	Yes	Yes	0	5	9
856	R:R:M109	R:R:W152	2.33	Yes	Yes	16	5	9
857	R:R:M109	R:R:T155	3.01	Yes	No	0	5	7
858	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
859	R:R:M109	R:R:T159	9.03	Yes	No	16	5	7
860	R:R:E196	R:R:R111	4.65	No	No	0	5	8
861	R:R:R111	R:R:T283	2.59	No	Yes	4	8	8
862	R:R:R111	R:R:Y284	2.06	No	Yes	4	8	7
863	R:R:Q112	R:R:T155	4.25	No	No	0	7	7
864	R:R:L158	R:R:Q112	3.99	No	No	0	5	7
865	R:R:M192	R:R:Q112	10.88	No	No	0	5	7
866	R:R:G113	R:R:T155	3.64	No	No	0	7	7
867	R:R:E196	R:R:I115	5.47	No	No	0	5	8
868	R:R:I115	R:R:P200	3.39	No	No	0	8	9
869	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
870	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
871	R:R:F117	R:R:L151	7.31	Yes	Yes	0	8	7
872	R:R:F117	R:R:W152	9.02	Yes	Yes	16	8	9
873	R:R:F240	R:R:L118	2.44	Yes	No	0	9	9
874	R:R:L118	R:R:Y294	3.52	No	Yes	0	9	9
875	R:R:P200	R:R:T119	3.5	No	No	0	9	7
876	R:R:I203	R:R:T119	4.56	No	No	0	7	7
877	R:R:R125	R:R:V121	6.54	No	No	12	9	9
878	R:R:V121	R:R:Y294	3.79	No	Yes	12	9	9
879	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
880	R:R:D124	R:R:R128	4.76	No	Yes	0	8	8
881	R:R:R125	R:R:Y294	4.12	No	Yes	12	9	9
882	R:R:V130	R:R:Y126	13.88	Yes	Yes	9	8	7
883	R:R:H131	R:R:Y126	4.36	No	Yes	9	7	7
884	R:R:F206	R:R:Y126	4.13	No	Yes	9	4	7
885	R:R:C207	R:R:Y126	5.38	No	Yes	0	8	7
886	R:R:R210	R:R:Y126	8.23	Yes	Yes	9	4	7
887	R:R:F127	R:R:H131	3.39	Yes	No	9	5	7
888	R:R:F127	R:R:H134	3.39	Yes	No	9	5	4
889	R:R:F127	R:R:L136	3.65	Yes	No	9	5	4
890	R:R:N137	R:R:R128	9.64	No	Yes	9	4	8
891	R:R:I211	R:R:V129	6.14	No	No	0	8	8
892	R:R:H131	R:R:V130	5.54	No	Yes	9	7	8
893	R:R:R210	R:R:V130	2.62	Yes	Yes	9	4	8
894	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
895	R:R:H133	R:R:P132	6.1	Yes	No	0	6	8
896	R:R:H134	R:R:L136	2.57	No	No	9	4	4
897	R:R:H134	R:R:N137	5.1	No	No	9	4	4
898	R:R:S140	R:R:T143	3.2	No	No	0	6	3
899	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
900	R:R:H161	R:R:L162	7.71	No	No	0	7	4
901	R:R:M167	R:R:P168	3.35	Yes	No	13	3	4
902	R:R:I169	R:R:M167	2.92	No	Yes	0	1	3
903	R:R:C177	R:R:M167	4.86	No	Yes	13	9	3
904	R:R:I169	R:R:L176	2.85	No	Yes	0	1	4
905	R:R:N175	R:R:Q170	6.6	No	No	0	4	1
906	R:R:L176	R:R:N171	2.75	Yes	Yes	18	4	1
907	R:R:G172	R:R:G173	2.11	No	No	0	3	4
908	R:R:L176	R:R:S178	3	Yes	No	0	4	4
909	R:R:S178	R:R:S181	3.26	No	No	0	4	4
910	R:R:H189	R:R:S179	8.37	No	No	0	5	4
911	R:R:F180	R:R:H189	7.92	Yes	No	0	3	5
912	R:R:E190	R:R:F180	2.33	Yes	Yes	4	4	3
913	R:R:F180	R:R:F193	2.14	Yes	Yes	4	3	6
914	R:R:F180	R:R:R251	2.14	Yes	Yes	4	3	5
915	R:R:F180	R:R:F276	8.57	Yes	Yes	4	3	4
916	R:R:F180	R:R:L280	3.65	Yes	Yes	4	3	5
917	R:R:I182	R:R:I254	2.94	Yes	No	0	3	4
918	R:R:I182	R:R:L258	4.28	Yes	No	4	3	3
919	R:R:I182	R:R:Y269	6.04	Yes	Yes	4	3	2
920	R:R:D273	R:R:I182	5.6	No	Yes	0	4	3
921	R:R:H184	R:R:T263	4.11	No	No	0	3	3
922	R:R:H184	W:W:?1	8.8	No	Yes	0	3	0
923	R:R:Q187	R:R:T185	4.25	No	No	0	2	2
924	R:R:F186	W:W:?1	8.33	No	Yes	0	4	0
925	R:R:E190	R:R:Q187	2.55	Yes	No	0	4	2
926	R:R:E190	R:R:R251	8.14	Yes	Yes	4	4	5
927	R:R:E190	W:W:?1	14.1	Yes	Yes	4	4	0
928	R:R:A191	W:W:?1	7.19	No	Yes	0	3	0
929	R:R:E196	R:R:F193	7	No	Yes	0	5	6
930	R:R:F193	R:R:R251	3.21	Yes	Yes	4	6	5
931	R:R:F193	R:R:F276	4.29	Yes	Yes	4	6	4
932	R:R:F193	R:R:L280	2.44	Yes	Yes	4	6	5
933	R:R:F255	R:R:L194	2.44	No	Yes	4	5	4
934	R:R:L194	W:W:?1	5.26	Yes	Yes	4	4	0
935	R:R:L195	R:R:L199	2.77	No	No	0	4	4
936	R:R:L195	W:W:?1	4.21	No	Yes	0	4	0
937	R:R:F197	R:R:F198	7.5	Yes	No	0	8	5
938	R:R:F197	R:R:L201	4.87	Yes	Yes	4	8	7
939	R:R:F197	R:R:F240	4.29	Yes	Yes	4	8	9
940	R:R:F197	R:R:F244	4.29	Yes	Yes	4	8	8
941	R:R:F197	R:R:L245	7.31	Yes	No	0	8	6
942	R:R:F198	W:W:?1	3.7	No	Yes	0	5	0
943	R:R:F240	R:R:P200	2.89	Yes	No	0	9	9
944	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
945	R:R:F240	R:R:L201	2.44	Yes	Yes	4	9	7
946	R:R:F206	R:R:R210	7.48	No	Yes	9	4	4
947	R:R:I233	R:R:S208	3.1	Yes	No	0	7	8
948	R:R:R210	R:R:W213	7	Yes	No	0	4	3
949	R:R:I211	R:R:I233	2.94	No	Yes	0	8	7
950	R:R:I212	R:R:R216	2.51	Yes	No	19	5	4
951	R:R:I212	R:R:I230	7.36	Yes	No	19	5	6
952	R:R:I212	R:R:M234	2.92	Yes	No	0	5	4
953	R:R:Q217	R:R:W213	15.33	No	No	0	5	3
954	R:R:Q217	R:R:S214	2.89	No	No	0	5	5
955	R:R:I226	R:R:L215	7.14	Yes	No	0	6	8
956	R:R:D221	R:R:R216	10.72	No	No	19	3	4
957	R:R:I230	R:R:R216	2.51	No	No	19	6	4
958	R:R:M220	R:R:R218	7.44	Yes	Yes	7	3	5
959	R:R:D221	R:R:K227	4.15	No	No	0	3	4
960	R:R:D221	R:R:I230	4.2	No	No	19	3	6
961	R:R:H223	R:R:K225	5.24	No	No	0	4	5
962	R:R:F232	R:R:R228	7.48	Yes	No	0	7	7
963	R:R:F232	R:R:T231	6.49	Yes	No	0	7	6
964	R:R:F232	R:R:V235	5.24	Yes	No	0	7	5
965	R:R:F232	R:R:S298	3.96	Yes	No	0	7	8
966	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
967	R:R:L289	R:R:V239	5.96	No	No	0	7	7
968	R:R:F240	R:R:F244	4.29	Yes	Yes	4	9	8
969	R:R:I242	R:R:V241	3.07	No	No	0	5	5
970	R:R:C243	R:R:M285	3.24	No	No	0	8	5
971	R:R:C243	R:R:N286	9.45	No	No	0	8	9
972	R:R:F244	R:R:T283	3.89	Yes	Yes	4	8	8
973	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
974	R:R:L245	R:R:P246	3.28	No	No	0	6	9
975	R:R:F282	R:R:P246	5.78	No	No	0	7	9
976	R:R:S247	R:R:T279	3.2	No	No	0	6	7
977	R:R:T279	R:R:V250	3.17	No	No	0	7	5
978	R:R:I254	R:R:R251	2.51	No	Yes	0	4	5
979	R:R:F255	R:R:R251	5.34	No	Yes	4	5	5
980	R:R:F276	R:R:R251	13.9	Yes	Yes	4	4	5
981	R:R:L257	R:R:R253	7.29	Yes	No	0	3	5
982	R:R:I254	R:R:V272	3.07	No	Yes	0	4	4
983	R:R:F255	W:W:?1	16.67	No	Yes	4	5	0
984	R:R:T260	R:R:W256	7.28	No	No	0	1	4
985	R:R:L257	R:R:Y269	2.34	Yes	Yes	4	3	2
986	R:R:L257	R:R:V272	4.47	Yes	Yes	4	3	4
987	R:R:L258	R:R:Y269	7.03	No	Yes	4	3	2
988	R:R:L258	W:W:?1	8.42	No	Yes	4	3	0
989	R:R:S261	R:R:T260	3.2	No	No	0	3	1
990	R:R:G262	R:R:S261	1.86	No	No	0	4	3
991	R:R:E267	R:R:N265	13.15	No	No	0	2	5
992	R:R:V272	R:R:Y269	2.52	Yes	Yes	4	4	2
993	R:R:S271	R:R:V272	3.23	No	Yes	0	3	4
994	R:R:D273	R:R:F277	7.17	No	No	0	4	5
995	R:R:I278	R:R:L274	2.85	No	No	0	6	1
996	R:R:F276	R:R:T279	2.59	Yes	No	0	4	7
997	R:R:F276	R:R:L280	6.09	Yes	Yes	4	4	5
998	R:R:L280	R:R:T283	4.42	Yes	Yes	4	5	8
999	R:R:L280	R:R:Y284	2.34	Yes	Yes	4	5	7
1000	R:R:T283	R:R:Y284	3.75	Yes	Yes	4	8	7
1001	R:R:M285	R:R:M288	4.33	No	No	0	5	8
1002	R:R:L289	R:R:M285	2.83	No	No	0	7	5
1003	R:R:D290	R:R:P291	3.22	Yes	Yes	0	9	9
1004	R:R:D290	R:R:Y294	5.75	Yes	Yes	0	9	9
1005	R:R:P291	R:R:Y295	2.78	Yes	Yes	0	9	7
1006	R:R:Y294	R:R:Y295	1.99	Yes	Yes	12	9	7
1007	R:R:C183	R:R:S181	1.72	No	No	0	1	4
1008	B:B:G1	B:B:L4	1.71	No	Yes	0	9	4
1009	A:A:G27	B:B:L55	1.71	No	No	0	5	6
1010	B:B:C103	B:B:V71	1.71	No	No	0	8	8
1011	B:B:G77	B:B:L95	1.71	No	Yes	0	8	8
1012	A:A:A7	A:A:S6	1.71	No	No	0	1	7
1013	A:A:G40	A:A:L39	1.71	No	Yes	0	9	9
1014	A:A:A41	A:A:S44	1.71	No	No	0	7	9
1015	A:A:A41	A:A:S246	1.71	No	No	0	7	9
1016	R:R:G46	R:R:L49	1.71	No	No	0	4	7
1017	R:R:A144	R:R:S61	1.71	No	No	0	7	6
1018	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
1019	B:B:A11	G:G:V16	1.7	No	No	0	5	7
1020	B:B:A26	G:G:V30	1.7	No	No	0	3	8
1021	B:B:A305	B:B:V40	1.7	No	Yes	0	4	3
1022	B:B:G238	B:B:N239	1.7	No	No	0	7	2
1023	B:B:A257	G:G:V30	1.7	No	No	0	7	8
1024	R:R:A108	R:R:T159	1.68	No	No	0	4	7
1025	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
1026	A:A:E43	A:A:G42	1.64	No	No	0	9	8
1027	A:A:E216	A:A:G217	1.64	No	No	0	7	5
1028	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
1029	B:B:A140	B:B:I120	1.62	No	No	0	5	6
1030	B:B:A248	B:B:I269	1.62	No	Yes	0	5	4
1031	B:B:A257	G:G:I28	1.62	No	No	0	7	4
1032	G:G:A33	G:G:I28	1.62	No	No	0	7	4
1033	A:A:A220	A:A:I265	1.62	No	Yes	0	8	8
1034	R:R:A122	R:R:I204	1.62	No	No	0	9	8
1035	R:R:A237	R:R:I204	1.62	No	No	0	7	8
1036	R:R:A229	R:R:I226	1.62	No	Yes	0	7	6
1037	B:B:S31	B:B:T29	1.6	No	No	0	1	3
1038	B:B:S207	B:B:T223	1.6	No	No	0	5	2
1039	R:R:V235	R:R:V236	1.6	No	No	0	5	8
1040	R:R:V236	R:R:V293	1.6	No	No	0	8	8
1041	R:R:V249	R:R:V250	1.6	No	No	0	6	5
1042	R:R:V292	R:R:V293	1.6	No	No	0	6	8
1043	A:A:T187	A:A:V50	1.59	No	No	0	6	6
1044	A:A:C351	A:A:L353	1.59	No	Yes	0	4	7
1045	R:R:C266	R:R:L11	1.59	No	No	0	7	8
1046	B:B:A11	G:G:L15	1.58	No	No	20	5	2
1047	B:B:A11	G:G:L19	1.58	No	Yes	20	5	9
1048	B:B:A299	B:B:L285	1.58	No	Yes	0	5	6
1049	A:A:A245	A:A:L234	1.58	No	No	0	9	8
1050	R:R:A108	R:R:L162	1.58	No	No	0	4	4
1051	R:R:A237	R:R:L205	1.58	No	No	0	7	4
1052	A:A:A12	B:B:N88	1.56	No	Yes	0	4	7
1053	A:A:A226	A:A:N269	1.56	No	No	0	8	9
1054	A:A:C305	A:A:D309	1.56	No	No	0	3	4
1055	G:G:I9	G:G:S8	1.55	No	No	0	2	4
1056	B:B:A28	B:B:D27	1.54	No	No	0	4	8
1057	B:B:A56	B:B:D76	1.54	No	No	0	7	9
1058	B:B:A193	B:B:D195	1.54	No	No	0	4	5
1059	A:A:I49	A:A:V50	1.54	Yes	No	0	7	6
1060	R:R:I156	R:R:V160	1.54	No	No	0	4	4
1061	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
1062	B:B:A56	B:B:Q75	1.52	No	Yes	0	7	9
1063	A:A:K54	A:A:V50	1.52	No	No	0	7	6
1064	R:R:K28	R:R:V27	1.52	No	No	0	3	3
1065	R:R:M84	R:R:V88	1.52	No	No	0	7	3
1066	R:R:F40	R:R:G41	1.51	No	No	0	6	8
1067	A:A:G352	R:R:R63	1.5	No	No	0	8	7
1068	R:R:L56	R:R:S58	1.5	Yes	No	0	5	6
1069	B:B:V327	G:G:L50	1.49	No	No	0	6	9
1070	A:A:L5	A:A:V13	1.49	No	No	0	2	3
1071	R:R:L194	R:R:V248	1.49	Yes	No	0	4	8
1072	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
1073	R:R:L257	R:R:V268	1.49	Yes	No	0	3	1
1074	A:A:N241	A:A:V233	1.48	No	No	0	9	5
1075	R:R:N68	R:R:V71	1.48	Yes	No	0	9	6
1076	R:R:I212	R:R:I233	1.47	Yes	Yes	0	5	7
1077	R:R:I238	R:R:I242	1.47	No	No	0	5	5
1078	B:B:N132	B:B:T128	1.46	No	Yes	0	3	3
1079	G:G:A43	G:G:H44	1.46	No	No	0	4	6
1080	A:A:D200	A:A:V185	1.46	No	No	0	9	5
1081	B:B:D322	B:B:T65	1.45	No	No	0	1	1
1082	A:A:I55	A:A:K54	1.45	No	No	0	8	7
1083	A:A:I278	A:A:K279	1.45	Yes	No	0	6	2
1084	A:A:D328	A:A:T329	1.45	No	No	0	9	9
1085	B:B:E3	B:B:S2	1.44	No	No	0	5	5
1086	B:B:Q75	B:B:S98	1.44	Yes	No	0	9	8
1087	G:G:Q11	G:G:S8	1.44	No	No	0	3	4
1088	A:A:E8	A:A:S6	1.44	No	No	0	5	7
1089	R:R:K15	R:R:K16	1.44	No	No	0	3	4
1090	R:R:I13	R:R:L11	1.43	No	No	0	3	8
1091	R:R:I98	R:R:L102	1.43	No	No	0	2	5
1092	R:R:I146	R:R:L150	1.43	No	No	0	3	4
1093	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
1094	R:R:I154	R:R:L158	1.43	No	No	0	5	5
1095	R:R:I252	R:R:L194	1.43	No	Yes	0	6	4
1096	R:R:E267	R:R:V268	1.43	No	No	0	2	1
1097	R:R:I64	R:R:N141	1.42	No	No	0	7	2
1098	B:B:K301	B:B:N35	1.4	Yes	No	0	5	1
1099	A:A:K51	A:A:N47	1.4	No	No	0	9	9
1100	A:A:K314	A:A:N311	1.4	No	Yes	0	3	8
1101	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
1102	A:A:P288	A:A:Y287	1.39	No	Yes	0	5	7
1103	G:G:A10	G:G:R13	1.38	No	No	0	2	6
1104	G:G:D36	G:G:K32	1.38	No	No	0	5	5
1105	A:A:R32	R:R:A135	1.38	No	No	0	4	5
1106	R:R:A145	R:R:R142	1.38	No	No	0	3	4
1107	A:A:E207	A:A:K209	1.35	No	No	0	9	8
1108	A:A:E276	A:A:K279	1.35	No	No	0	5	2
1109	B:B:L7	B:B:Q6	1.33	No	No	0	8	1
1110	B:B:E10	B:B:L7	1.33	No	No	0	8	8
1111	B:B:N16	B:B:Q13	1.32	No	No	0	1	1
1112	A:A:R208	A:A:S252	1.32	Yes	No	0	9	7
1113	R:R:F232	R:R:S297	1.32	Yes	No	0	7	6
1114	A:A:H195	A:A:K197	1.31	No	Yes	0	4	6
1115	R:R:F296	R:R:V292	1.31	No	No	0	8	6
1116	A:A:D237	A:A:E238	1.3	No	No	0	8	4
1117	A:A:D237	A:A:E239	1.3	No	No	0	8	4
1118	R:R:A191	R:R:W188	1.3	No	No	0	3	5
1119	B:B:D267	B:B:H266	1.26	No	Yes	0	3	4
1120	R:R:F74	R:R:I78	1.26	No	No	0	7	6
1121	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9
1122	R:R:H259	R:R:W256	1.06	No	No	0	1	4
1123	R:R:R253	R:R:W256	1	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	B:B:L4	3.98	4	0	4
2	B:B:L14	4.815	4	0	8
3	B:B:R22	7.6825	4	21	6
4	B:B:T34	4.8375	4	2	5
5	B:B:V40	2.77	4	0	3
6	B:B:L51	7.89	4	5	9
7	B:B:H54	8.438	5	0	9
8	B:B:Y59	5.9725	4	1	8
9	B:B:M61	3.2325	4	5	6
10	B:B:W63	5.30833	6	5	7
11	B:B:Q75	4.784	5	1	9
12	B:B:I81	4.2625	4	8	7
13	B:B:W82	8.87833	6	5	9
14	B:B:N88	4.356	5	23	7
15	B:B:K89	8.9575	4	0	9
16	B:B:I93	4.335	4	8	7
17	B:B:L95	3.615	4	8	8
18	B:B:W99	6.23833	6	1	9
19	B:B:Y105	3.81	7	8	6
20	B:B:Y111	6.252	5	0	4
21	B:B:C114	4.64	4	8	8
22	B:B:L117	3.8725	4	1	9
23	B:B:Y124	3.72167	6	8	6
24	B:B:L126	4.185	4	8	5
25	B:B:T128	3.1375	4	24	3
26	B:B:H142	6.66143	7	1	9
27	B:B:Y145	4.53778	9	1	8
28	B:B:C149	2.205	4	1	8
29	B:B:F151	3.87	7	1	9
30	B:B:T159	5.1	4	1	9
31	B:B:G162	4.1025	4	1	9
32	B:B:D163	8.75	4	1	9
33	B:B:W169	8.82	6	1	8
34	B:B:Q176	7.2575	4	1	4
35	B:B:T178	3.9675	4	6	4
36	B:B:F180	7.346	5	6	7
37	B:B:H183	6.53333	6	6	9
38	B:B:D186	4.366	5	1	9
39	B:B:L190	3.69	4	0	5
40	B:B:F199	6.77	4	6	9
41	B:B:V200	5.31	5	2	6
42	B:B:C204	5.54	4	1	7
43	B:B:D205	5.265	4	6	9
44	B:B:K209	7.018	5	6	6
45	B:B:L210	3.735	4	0	5
46	B:B:W211	8.66167	6	6	8
47	B:B:D212	6.9025	4	6	9
48	B:B:E215	9.2475	4	6	3
49	B:B:C218	4.445	4	6	5
50	B:B:Q220	5.3825	4	0	7
51	B:B:F222	7.03	4	2	8
52	B:B:H225	8.37857	7	2	9
53	B:B:I232	4.082	5	2	8
54	B:B:F235	5.53143	7	15	6
55	B:B:P236	5.3075	4	15	7
56	B:B:F241	6.13571	7	2	6
57	B:B:T243	4.18667	6	2	8
58	B:B:G244	2.2875	4	2	5
59	B:B:D247	6.16	5	2	9
60	B:B:T249	5.88	4	2	6
61	B:B:C250	2.8425	4	2	8
62	B:B:R251	10.328	5	2	8
63	B:B:F253	6	6	2	6
64	B:B:M262	4.7975	4	2	4
65	B:B:Y264	3.94	5	2	5
66	B:B:H266	3.345	4	0	4
67	B:B:I269	2.865	4	2	4
68	B:B:I273	4.3625	4	2	6
69	B:B:F278	4.24	4	15	7
70	B:B:L285	2.9425	4	0	6
71	B:B:Y289	5.51	6	2	7
72	B:B:N293	4.895	4	0	5
73	B:B:N295	8.3275	4	2	6
74	B:B:W297	3.73833	6	2	8
75	B:B:K301	4.37	4	22	5
76	B:B:R304	6.7325	4	2	5
77	B:B:H311	7.54	5	10	9
78	B:B:L318	3.254	5	0	6
79	B:B:T321	5.83	4	5	7
80	B:B:W332	10.9783	6	1	9
81	B:B:D333	8.2375	4	10	9
82	B:B:L336	3.93	6	5	7
83	B:B:K337	6.015	4	10	6
84	B:B:W339	9.542	5	10	9
85	G:G:Q18	7.6875	4	6	9
86	G:G:L19	2.83	4	20	9
87	G:G:E22	6.725	4	6	9
88	G:G:Y40	8.7975	4	15	6
89	G:G:L51	6.3475	4	0	6
90	G:G:V54	4.74	4	17	6
91	G:G:F61	5.44875	8	5	8
92	A:A:V34	5.24	5	7	5
93	A:A:L39	4.4575	4	3	9
94	A:A:K46	4.064	5	25	9
95	A:A:I49	4.1875	4	11	7
96	A:A:L194	5.1425	4	7	4
97	A:A:F196	7.298	5	7	7
98	A:A:K197	5.6725	4	1	6
99	A:A:F199	6.544	5	1	5
100	A:A:R208	3.805	4	0	9
101	A:A:K210	5.795	6	1	9
102	A:A:W211	4.345	6	1	9
103	A:A:H213	5.25	4	1	8
104	A:A:C214	2.85	4	1	7
105	A:A:F215	4.52125	8	1	9
106	A:A:F223	4.875	6	3	9
107	A:A:V225	4.58	4	3	7
108	A:A:Y230	6.90167	6	3	8
109	A:A:R242	8.6825	4	3	9
110	A:A:H244	6.96	4	26	4
111	A:A:F250	4.965	6	3	9
112	A:A:C254	3.8525	4	3	5
113	A:A:W258	8.026	5	1	5
114	A:A:F259	6.6525	4	3	9
115	A:A:I265	2.4725	4	11	8
116	A:A:L266	4.3425	4	3	9
117	A:A:F267	4.41125	8	11	9
118	A:A:L268	4.52	5	3	8
119	A:A:F274	4.415	6	3	9
120	A:A:I278	3.585	4	3	6
121	A:A:S281	4.14	4	3	7
122	A:A:L283	3.91	5	3	7
123	A:A:Y287	3.75667	6	0	7
124	A:A:Y290	9.1075	4	0	7
125	A:A:F307	4.048	5	3	8
126	A:A:N311	3.398	5	3	8
127	A:A:R313	4.64	4	3	4
128	A:A:K317	3.835	4	3	7
129	A:A:T321	7.1925	4	3	5
130	A:A:H322	5.684	5	11	9
131	A:A:F323	4.944	5	3	4
132	A:A:T324	5.16	5	11	9
133	A:A:N331	6.74333	6	11	8
134	A:A:F334	4.7875	4	11	3
135	A:A:F336	5.455	6	7	8
136	A:A:T340	4.614	5	7	6
137	A:A:I344	4.4275	4	7	6
138	A:A:L353	3.97	4	0	7
139	A:A:F354	7.415	4	27	5
140	R:R:E12	5.295	4	18	5
141	R:R:F21	6.01333	6	4	2
142	R:R:L30	2.9375	4	0	5
143	R:R:E37	4.2875	4	4	7
144	R:R:F38	4.375	4	29	7
145	R:R:F52	4.152	5	12	7
146	R:R:L56	3.6425	4	12	5
147	R:R:N68	7.34	4	16	9
148	R:R:L69	4.955	4	0	9
149	R:R:Y87	7.04	4	28	6
150	R:R:W93	3.905	6	13	9
151	R:R:C100	6.145	4	13	9
152	R:R:M103	3.0975	4	0	5
153	R:R:M109	4.68	6	16	5
154	R:R:N110	6.5725	4	0	9
155	R:R:F117	8.015	4	16	8
156	R:R:Y126	7.196	5	9	7
157	R:R:F127	3.2625	4	9	5
158	R:R:R128	5.3975	4	9	8
159	R:R:V130	6.7225	4	9	8
160	R:R:H133	6.1675	4	0	6
161	R:R:L151	4.325	4	0	7
162	R:R:W152	4.8975	4	16	9
163	R:R:M167	3.722	5	13	3
164	R:R:N171	3.345	4	18	1
165	R:R:L176	3.41	5	18	4
166	R:R:F180	4.45833	6	4	3
167	R:R:I182	4.715	4	4	3
168	R:R:E190	6.78	4	4	4
169	R:R:F193	3.816	5	4	6
170	R:R:L194	2.655	4	4	4
171	R:R:F197	5.652	5	4	8
172	R:R:L201	2.656	5	4	7
173	R:R:R210	6.3325	4	9	4
174	R:R:I212	3.565	4	19	5
175	R:R:R218	4.985	4	7	5
176	R:R:M220	6.1425	4	7	3
177	R:R:I226	4.4725	4	27	6
178	R:R:F232	4.898	5	0	7
179	R:R:I233	2.59	4	0	7
180	R:R:F240	3.27	5	4	9
181	R:R:F244	5.694	5	4	8
182	R:R:R251	5.87333	6	4	5
183	R:R:L257	3.8975	4	4	3
184	R:R:Y269	3.998	5	4	2
185	R:R:V272	3.3225	4	4	4
186	R:R:F276	7.088	5	4	4
187	R:R:L280	3.788	5	4	5
188	R:R:T283	3.6625	4	4	8
189	R:R:Y284	3.14429	7	4	7
190	R:R:D290	5.6225	4	0	9
191	R:R:P291	4.045	4	0	9
192	R:R:Y294	4.45667	6	12	9
193	R:R:Y295	3.81857	7	12	7
194	W:W:?1	8.52	9	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:I18	B:B:R22	10.2419	2.51	No	Yes	0	7	6
2	B:B:D258	B:B:R22	11.7656	20.25	No	Yes	21	7	6
3	B:B:G244	B:B:T243	37.6826	1.82	Yes	Yes	2	5	8
4	B:B:F241	B:B:T243	15.6589	2.59	Yes	Yes	2	6	8
5	B:B:F222	B:B:Q220	12.3084	8.2	Yes	Yes	0	8	7
6	B:B:D258	B:B:Q220	13.2974	5.22	No	Yes	0	7	7
7	B:B:G244	B:B:I273	37.832	3.53	Yes	Yes	2	5	6
8	B:B:G272	B:B:I273	46.3707	1.76	No	Yes	2	4	6
9	B:B:D290	B:B:G272	46.5023	3.35	No	No	2	6	4
10	B:B:D290	B:B:R314	50.7897	13.1	No	No	0	6	8
11	B:B:R314	B:B:T274	11.4847	2.59	No	No	0	8	8
12	B:B:R314	B:B:W332	60.8402	20.99	No	Yes	0	8	9
13	B:B:S316	B:B:W332	18.6281	3.71	No	Yes	0	9	9
14	B:B:C317	B:B:S316	18.4137	3.44	No	No	0	7	9
15	B:B:C317	B:B:M61	12.0119	4.86	No	Yes	0	7	6
16	A:A:H213	B:B:W332	72.4679	4.23	Yes	Yes	1	8	9
17	B:B:H62	B:B:Y105	29.7379	4.36	No	Yes	0	6	6
18	B:B:H62	B:B:R150	29.5138	12.41	No	No	0	6	6
19	B:B:L190	B:B:R150	18.4445	2.43	Yes	No	0	5	6
20	B:B:F199	B:B:V158	18.2152	3.93	Yes	No	0	9	5
21	B:B:L210	B:B:R219	12.4929	2.43	Yes	No	0	5	5
22	B:B:L192	B:B:R150	10.8763	2.43	No	No	0	5	6
23	A:A:C214	A:A:H213	54.9703	2.95	Yes	Yes	1	7	8
24	B:B:V112	B:B:Y105	24.6455	2.52	No	Yes	8	8	6
25	B:B:V112	B:B:Y124	26.5804	3.79	No	Yes	8	8	6
26	B:B:C114	B:B:L95	31.1599	4.76	Yes	Yes	8	8	8
27	B:B:L95	B:B:Y124	30.6275	3.52	Yes	Yes	8	8	6
28	B:B:L117	B:B:W99	16.2386	5.69	Yes	Yes	1	9	9
29	A:A:C214	A:A:F215	53.0234	2.79	Yes	Yes	1	7	9
30	B:B:L117	B:B:M101	25.0734	2.83	Yes	No	1	9	9
31	B:B:G116	B:B:M101	37.863	3.49	No	No	0	9	9
32	A:A:F215	A:A:W211	29.0513	2	Yes	Yes	1	9	9
33	A:A:W211	B:B:Y145	22.3642	3.86	Yes	Yes	1	9	8
34	B:B:C114	B:B:G115	35.0346	3.92	Yes	No	0	8	9
35	B:B:G115	B:B:G116	37.4786	2.11	No	No	0	9	9
36	B:B:L210	B:B:V200	13.5966	2.98	Yes	Yes	0	5	6
37	B:B:A193	B:B:F234	12.0096	2.77	No	No	0	4	5
38	A:A:I222	A:A:L38	52.321	2.85	No	No	0	7	8
39	A:A:K46	A:A:L38	52.2932	4.23	Yes	No	25	9	8
40	A:A:G40	A:A:K46	100	6.97	No	Yes	0	9	9
41	A:A:G40	A:A:L39	99.9436	1.71	No	Yes	0	9	9
42	A:A:L37	A:A:L39	90.4191	5.54	No	Yes	0	9	9
43	A:A:F215	A:A:L37	90.3324	7.31	Yes	No	0	9	9
44	A:A:I212	A:A:W258	18.714	2.35	No	Yes	0	8	5
45	A:A:H213	A:A:W258	17.9951	11.64	Yes	Yes	1	8	5
46	A:A:F223	A:A:L39	27.495	4.87	Yes	Yes	3	9	9
47	A:A:F223	A:A:L249	15.5878	6.09	Yes	No	0	9	9
48	A:A:L249	A:A:R208	15.5562	3.64	No	Yes	0	9	9
49	A:A:F274	A:A:Y230	13.0299	5.16	Yes	Yes	3	9	8
50	A:A:F223	A:A:V225	25.9774	2.62	Yes	Yes	3	9	7
51	A:A:F274	A:A:I303	14.6304	2.51	Yes	No	0	9	7
52	A:A:F307	A:A:I303	21.6327	2.51	Yes	No	0	8	7
53	A:A:F307	A:A:V225	15.8535	7.87	Yes	Yes	3	8	7
54	A:A:F307	A:A:L266	16.0394	2.44	Yes	Yes	3	8	9
55	A:A:F223	A:A:L266	16.901	2.44	Yes	Yes	3	9	9
56	A:A:F267	A:A:I49	45.1272	6.28	Yes	Yes	11	9	7
57	A:A:C224	A:A:I49	47.3595	3.27	No	Yes	0	7	7
58	A:A:C224	A:A:K46	47.4342	3.23	No	Yes	0	7	9
59	A:A:F267	A:A:I222	45.4305	2.51	Yes	No	0	9	7
60	A:A:F267	A:A:F334	87.3247	2.14	Yes	Yes	11	9	3
61	R:R:H223	R:R:K225	92.4038	5.24	No	No	0	4	5
62	A:A:E318	R:R:H223	92.6241	3.69	No	No	0	4	4
63	A:A:E318	A:A:Y320	87.7319	8.98	No	No	0	4	7
64	A:A:F334	A:A:Y320	87.8025	2.06	Yes	No	0	3	7
65	A:A:F354	A:A:L348	90.7404	9.74	Yes	No	27	5	9
66	A:A:F354	R:R:K225	91.9625	6.2	Yes	No	0	5	5
67	A:A:L348	A:A:L353	90.6335	4.15	No	Yes	0	9	7
68	A:A:L353	R:R:R125	87.5014	7.29	Yes	No	0	7	9
69	R:R:R125	R:R:Y294	83.0825	4.12	No	Yes	12	9	9
70	R:R:L118	R:R:Y294	54.1581	3.52	No	Yes	0	9	9
71	R:R:F240	R:R:L118	53.9059	2.44	Yes	No	0	9	9
72	R:R:F197	R:R:F240	19.3255	4.29	Yes	Yes	4	8	9
73	R:R:F197	R:R:F198	18.3861	7.5	Yes	No	0	8	5
74	R:R:F198	W:W:?1	18.1142	3.7	No	Yes	0	5	0
75	R:R:L258	W:W:?1	12.3173	8.42	No	Yes	4	3	0
76	R:R:F240	R:R:F244	29.8967	4.29	Yes	Yes	4	9	8
77	R:R:F244	R:R:T283	25.8128	3.89	Yes	Yes	4	8	8
78	R:R:T283	R:R:Y284	20.958	3.75	Yes	Yes	4	8	7
79	R:R:L107	R:R:Y284	16.9124	2.34	No	Yes	4	6	7
80	R:R:C79	R:R:L107	16.6448	4.76	No	No	0	6	6
81	R:R:C79	R:R:M103	16.8735	3.24	No	Yes	0	6	5
82	R:R:D290	R:R:Y294	12.1141	5.75	Yes	Yes	0	9	9
83	R:R:Y294	R:R:Y295	15.1506	1.99	Yes	Yes	12	9	7
84	R:R:F117	R:R:L69	16.8242	2.44	Yes	Yes	0	8	9
85	B:B:I232	B:B:T243	13.4796	3.04	Yes	Yes	2	8	8
86	B:B:F241	B:B:V200	10.2179	6.55	Yes	Yes	2	6	6
87	A:A:F215	B:B:W99	11.5932	12.03	Yes	Yes	1	9	9
88	A:A:W211	B:B:L117	12.9605	2.28	Yes	Yes	1	9	9
89	B:B:M101	B:B:Y145	13.182	3.59	No	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E190	R:R:F180	2.33	4	Yes	Yes	4	3	1	2
R:R:F180	R:R:R251	2.14	4	Yes	Yes	3	5	2	2
R:R:I182	R:R:L258	4.28	4	Yes	No	3	3	2	1
R:R:I182	R:R:Y269	6.04	4	Yes	Yes	3	2	2	2
R:R:H184	R:R:T263	4.11	0	No	No	3	3	1	2
R:R:H184	W:W:?1	8.8	0	No	Yes	3	0	1	0
R:R:F186	W:W:?1	8.33	0	No	Yes	4	0	1	0
R:R:E190	R:R:Q187	2.55	4	Yes	No	4	2	1	2
R:R:E190	R:R:R251	8.14	4	Yes	Yes	4	5	1	2
R:R:E190	W:W:?1	14.1	4	Yes	Yes	4	0	1	0
R:R:A191	W:W:?1	7.19	0	No	Yes	3	0	1	0
R:R:F255	R:R:L194	2.44	4	No	Yes	5	4	1	1
R:R:L194	W:W:?1	5.26	4	Yes	Yes	4	0	1	0
R:R:L195	R:R:L199	2.77	0	No	No	4	4	1	2
R:R:L195	W:W:?1	4.21	0	No	Yes	4	0	1	0
R:R:F197	R:R:F198	7.5	4	Yes	No	8	5	2	1
R:R:F198	W:W:?1	3.7	0	No	Yes	5	0	1	0
R:R:F255	R:R:R251	5.34	4	No	Yes	5	5	1	2
R:R:F255	W:W:?1	16.67	4	No	Yes	5	0	1	0
R:R:L258	R:R:Y269	7.03	4	No	Yes	3	2	1	2
R:R:L258	W:W:?1	8.42	4	No	Yes	3	0	1	0
R:R:L194	R:R:V248	1.49	4	Yes	No	4	8	1	2
R:R:I252	R:R:L194	1.43	0	No	Yes	6	4	2	1
R:R:A191	R:R:W188	1.3	0	No	No	3	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
88.89	Single	8J6Q	Compound 9n	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
88.89	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
88.89	Consensus	hca2_on_allo	Other Ligand	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
15.00	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
14.29	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
14.29	Consensus	cyslt2_off	Orthosteric Ligand	6RZ6-CysLT₂-ONO-2570366 6RZ9-CysLT₂-ONO-2770372 6RZ8-CysLT₂-ONO-2080365
14.29	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off
13.64	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.04	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
11.11	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
10.53	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
10.53	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.34	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.00	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.00	Single	7EPE	NAM563	7EPE-mGlu-NAM563
10.00	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
10.00	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
9.52	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.38	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
9.09	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.57	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
8.00	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.89	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
7.69	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
7.69	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.41	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14	Single	7VDM	Substance P	7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14	Single	7Y14	Beta-alanine	7Y14-MRGPRD-Beta-alanine
7.14	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
7.14	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
6.90	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.90	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
6.67	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
6.67	Single	6OBA	GTPL11074	6OBA-β₂-(S)-Alprenolol-GTPL11074
6.67	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
6.67	Single	7S8O	(R)-Zinc-3573	7S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67	Single	7Y12	Beta-alanine	7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.67	Single	8F76	-	8F76-OR51E2-Gs/&β;1/&γ;2
6.67	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.67	Single	8WG8	Peptide	8WG8-Glucagon-Peptide-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Consensus	beta2_off_allo	Other Ligand	6OBA-β₂-(S)-Alprenolol-GTPL11074
6.67	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
6.67	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
6.45	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
6.45	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
6.25	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
6.25	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
6.25	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
6.25	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2
6.25	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
5.88	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
5.88	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
5.88	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.88	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
5.88	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
5.88	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
5.88	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
5.88	Single	8U8F	PML	8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.88	Consensus	class-f_off	Orthosteric Ligand	smo_off
5.88	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88	Consensus	gi_histamine	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/&β;1/&γ;2 8HOC-H₄-Imetit-Gi1/&β;1/&γ;2
5.88	Consensus	gs_histamine	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	h4_on	Orthosteric Ligand	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
5.71	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
5.71	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
5.56	Single	5O9H	NDT9513727	5O9H-C5a₁-NDT9513727
5.56	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
5.56	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.56	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
5.56	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.56	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
5.56	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
5.56	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
5.56	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.56	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
5.56	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
5.26	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
5.26	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
5.26	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
5.26	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
5.26	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
5.26	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.26	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
5.26	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.26	Consensus	c5a1_off_ortoallo	Other Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
5.26	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
5.26	Consensus	histamine_on	Orthosteric Ligand	h1_on h4_on
5.26	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
5.13	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
5.00	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
5.00	Single	5N2R	PubChem 92460631; psb36	5N2R-A_2A-PubChem 92460631; psb36-Na
5.00	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
5.00	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
5.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
5.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
5.00	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
5.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.88	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
4.76	Single	5V56	TC114	5V56-SMO-TC114
4.76	Single	5V57	TC114	5V57-SMO-TC114
4.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.76	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2
4.76	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
4.76	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
4.76	Single	7W41	PD176252	7W41-BB₂-PD176252
4.76	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.76	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
4.76	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
4.76	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
4.76	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
4.76	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/&β;1/&γ;2
4.76	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/&β;1/&γ;2
4.76	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/&β;1/&γ;2
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.76	Single	8X16	Piclidenoson	8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
4.76	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.76	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.76	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.76	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
4.76	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.76	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
4.76	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
4.76	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.55	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
4.55	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.55	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
4.55	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.55	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.55	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
4.55	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
4.55	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.55	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.55	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
4.55	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
4.55	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.55	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/&β;1/&γ;2
4.55	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
4.55	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
4.55	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
4.55	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
4.55	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
4.55	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.55	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.55	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
4.55	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.35	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
4.35	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
4.35	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.35	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
4.35	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
4.35	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
4.35	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
4.35	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
4.35	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
4.35	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
4.35	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
4.35	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
4.17	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
4.17	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
4.17	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
4.17	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
4.17	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
4.17	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
4.00	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
4.00	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
4.00	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
4.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
4.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
4.00	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
4.00	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
4.00	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
4.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
4.00	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.85	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
3.85	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.85	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
3.85	Single	7SHE	PI; PE	7SHE-GPR158-PI; PE
3.85	Single	7SHF	PI; PE	7SHF-GPR158-PI; PE-B5; RGS7
3.85	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
3.85	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
3.85	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
3.70	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
3.70	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.70	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.70	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
3.70	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
3.70	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
3.57	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.57	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.57	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
3.57	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.57	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
3.57	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.57	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
3.57	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
3.57	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.57	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.57	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
3.57	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.57	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
3.57	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.45	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.45	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
3.45	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.45	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.45	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.45	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
3.45	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
3.45	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
3.45	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.45	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.45	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
3.45	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
3.45	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.45	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.33	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
3.33	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.33	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.33	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
3.33	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
3.33	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
3.33	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.33	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
3.33	Consensus	class-d_on	Orthosteric Ligand	ste2_on
3.33	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.33	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.33	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.33	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
3.33	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.33	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
3.23	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
3.23	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.23	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.23	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.23	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.23	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.23	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.23	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.23	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
3.23	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.23	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.23	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
3.23	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
3.23	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
3.23	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.23	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.23	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
3.12	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.12	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
3.12	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
3.12	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.12	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.12	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.12	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
3.12	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.12	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.12	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.12	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
3.12	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
3.12	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.12	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.12	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
3.12	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.03	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
3.03	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.03	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
3.03	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.03	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.03	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.03	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.03	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.03	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.03	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.94	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
2.94	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.94	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
2.94	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
2.94	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.94	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.94	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
2.94	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
2.86	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.86	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.86	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.86	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.86	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
2.86	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.86	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
2.78	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
2.78	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.78	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.78	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
2.78	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
2.78	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
2.78	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.70	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.70	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
2.63	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.56	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
2.56	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.50	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2

PDB Summary
PDB	8JHY
Class	A
SubFamily	Alicarboxylic acid
Type	Hydroxycarboxylic acid
SubType	HCA2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Compound 9n
Protein Partners	Gi1/Beta1/Gamma2
PDB Resolution	2.87
Date	2023-09-06
D.O.I.	10.1016/j.molcel.2023.07.030

Net Summary
I_min	1.74
Number of Linked Nodes	864
Number of Links	1123
Number of Hubs	194
Number of Links mediated by Hubs	706
Number of Communities	30
Number of Nodes involved in Communities	317
Number of Links involved in Communities	466

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	1663901
Length Of Smallest Path	3
Average Path Length	27.0605
Length of Longest Path	59
Minimum Path Strength	1.03
Average Path Strength	4.99493
Maximum Path Strength	22.68
Minimum Path Correlation	0.7
Average Path Correlation	0.985643
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	47.7036
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7821
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IX8
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	IX8
Name	7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Synonyms
Identifier	7-methyl-~{N}-[(2~{R})-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Formula	C26 H28 N4 O2
Molecular Weight	428.526
SMILES	Cc1c(cnc2n1ncc2c3ccc(cc3)C(C)C)C(=O)N[C@H](C)COc4ccccc4
PubChem	25101223
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	1
Total Bonds	63
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8JHY_Chain_B G S E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8JHY_Chain_G T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>8JHY_Chain_A G C T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K N T I V K Q M K I G I V E T H F T F K D L H F K M F D V G A Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A E D E E M N R M H A S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C S T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8JHY_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	hca2_on	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.01	2023-10-11	To be published
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/&β;1/&γ;2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/&β;1/&γ;2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acifran	-	Gi1/&β;1/&γ;2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	-	-	Gi1/&β;1/&γ;2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/&β;1/&γ;2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Go/&β;1/&γ;2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Go/&β;1/&γ;2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Go/&β;1/&γ;2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/&β;1/&γ;2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/&β;1/&γ;2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Beta-hydroxybutyrate	Compound 9n	Gi1/&β;1/&γ;2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	Go/&β;1/&γ;2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MMF	-	Go/&β;1/&γ;2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/&β;1/&γ;2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/&β;1/&γ;2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MMF	-	Gi1/&β;1/&γ;2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK6892	-	Gi1/&β;1/&γ;2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8

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