psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E12	R:R:F10	4.66	No	Yes	5	5	7
2	R:R:F10	R:R:N17	9.67	Yes	Yes	5	7	5
3	R:R:L11	R:R:N171	9.61	No	No	0	8	1
4	R:R:E12	R:R:N17	3.94	No	Yes	5	5	5
5	R:R:C18	R:R:I13	4.91	No	No	0	9	3
6	R:R:D14	R:R:K166	9.68	No	No	0	5	4
7	R:R:K16	R:R:T185	9.01	No	No	0	4	2
8	R:R:K16	R:R:Q187	4.07	No	No	0	4	2
9	R:R:N17	R:R:T263	4.39	Yes	No	0	5	3
10	H:H:?1	R:R:N17	29.57	No	Yes	0	0	5
11	R:R:C18	R:R:C183	7.28	No	No	0	9	1
12	R:R:C19	R:R:C266	7.28	No	No	0	4	7
13	R:R:N171	R:R:V20	4.43	No	No	0	1	2
14	R:R:L176	R:R:V20	7.45	Yes	No	0	4	2
15	R:R:F21	R:R:R270	4.28	No	No	0	2	1
16	R:R:D273	R:R:F21	7.17	No	No	0	4	2
17	R:R:R22	R:R:R90	10.66	Yes	No	0	3	4
18	R:R:D92	R:R:R22	5.96	No	Yes	0	4	3
19	R:R:N171	R:R:R22	3.62	No	Yes	0	1	3
20	R:R:A174	R:R:R22	5.53	No	Yes	0	2	3
21	R:R:D23	R:R:F25	4.78	No	No	0	4	6
22	R:R:D23	R:R:L274	8.14	No	No	0	4	1
23	R:R:I26	R:R:L30	5.71	No	Yes	1	5	5
24	R:R:I26	R:R:Y87	4.84	No	Yes	1	5	6
25	R:R:L30	R:R:Y87	10.55	Yes	Yes	1	5	6
26	R:R:L30	R:R:S281	6.01	Yes	No	0	5	6
27	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
28	R:R:M84	R:R:P31	3.35	No	Yes	0	7	6
29	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
30	R:R:L34	R:R:L83	4.15	No	Yes	1	8	6
31	R:R:L34	R:R:Y284	5.86	No	Yes	1	8	7
32	R:R:G35	R:R:M84	3.49	No	No	0	5	7
33	R:R:E37	R:R:Y284	4.49	No	Yes	0	7	7
34	R:R:F38	R:R:L42	8.53	Yes	No	0	7	7
35	R:R:F38	R:R:I77	5.02	Yes	No	0	7	6
36	R:R:F38	R:R:L80	4.87	Yes	No	0	7	8
37	R:R:F38	R:R:P81	8.67	Yes	No	0	7	8
38	R:R:F40	R:R:I39	6.28	No	No	0	6	5
39	R:R:F40	R:R:M288	3.73	No	No	0	6	8
40	R:R:G41	R:R:I77	5.29	No	No	0	8	6
41	R:R:F74	R:R:L42	4.87	No	No	0	7	7
42	R:R:G44	R:R:P291	4.06	No	Yes	0	7	9
43	R:R:D73	R:R:N45	8.08	Yes	No	0	9	9
44	R:R:N45	R:R:P291	11.4	No	Yes	0	9	9
45	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
46	R:R:F54	R:R:W50	9.02	No	No	0	4	4
47	R:R:H55	R:R:W50	4.23	No	No	0	5	4
48	R:R:F52	R:R:F67	6.43	No	Yes	0	7	6
49	R:R:F52	R:R:Y295	5.16	No	Yes	0	7	7
50	R:R:C53	R:R:F54	5.59	No	No	0	4	4
51	R:R:L56	R:R:W59	10.25	No	No	0	5	6
52	R:R:K60	R:R:S58	4.59	No	No	0	7	6
53	R:R:I64	R:R:W59	4.7	No	No	0	7	6
54	R:R:F67	R:R:W59	11.02	Yes	No	0	6	6
55	R:R:R128	R:R:S61	3.95	Yes	No	0	8	6
56	R:R:I139	R:R:S61	6.19	No	No	0	7	6
57	R:R:D124	R:R:S62	5.89	No	No	6	8	8
58	R:R:R128	R:R:S62	7.91	Yes	No	6	8	8
59	R:R:L66	R:R:R63	3.64	No	No	0	8	7
60	R:R:I64	R:R:N141	4.25	No	No	0	7	2
61	R:R:A144	R:R:I64	6.5	No	No	0	7	7
62	R:R:F65	R:R:V120	9.18	No	No	0	7	7
63	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
64	R:R:L66	R:R:Y295	5.86	No	Yes	2	8	7
65	R:R:F117	R:R:N68	13.29	No	No	7	8	9
66	R:R:N68	R:R:S148	8.94	No	No	0	9	8
67	R:R:N68	R:R:W152	5.65	No	Yes	7	9	9
68	R:R:D73	R:R:L69	4.07	Yes	Yes	2	9	9
69	R:R:D290	R:R:L69	4.07	Yes	Yes	2	9	9
70	R:R:L69	R:R:Y294	3.52	Yes	Yes	2	9	9
71	R:R:L69	R:R:Y295	4.69	Yes	Yes	2	9	7
72	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
73	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
74	R:R:D73	R:R:S287	11.78	Yes	No	0	9	8
75	R:R:D290	R:R:D73	6.65	Yes	Yes	2	9	9
76	R:R:L75	R:R:N110	6.87	No	No	0	6	9
77	R:R:L76	R:R:N110	8.24	No	No	0	7	9
78	R:R:L76	R:R:S287	6.01	No	No	0	7	8
79	R:R:C79	R:R:M106	4.86	No	No	0	6	5
80	R:R:C79	R:R:L107	9.52	No	Yes	0	6	6
81	R:R:F82	R:R:F95	7.5	No	No	0	6	7
82	R:R:F82	R:R:M103	8.71	No	No	0	6	5
83	R:R:L83	R:R:Y87	3.52	Yes	Yes	1	6	6
84	R:R:L107	R:R:L83	5.54	Yes	Yes	1	6	6
85	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
86	L:L:?1	R:R:L83	9.71	Yes	Yes	1	0	6
87	R:R:D85	R:R:R89	16.68	No	No	0	4	4
88	R:R:D85	R:R:F95	7.17	No	No	0	4	7
89	R:R:N86	R:R:W91	7.91	No	Yes	0	5	4
90	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
91	L:L:?1	R:R:N86	3.61	Yes	No	0	0	5
92	R:R:W91	R:R:Y87	4.82	Yes	Yes	1	4	6
93	R:R:D92	R:R:R89	5.96	No	No	0	4	4
94	R:R:L176	R:R:W91	3.42	Yes	Yes	1	4	4
95	R:R:S178	R:R:W91	4.94	No	Yes	1	4	4
96	R:R:F277	R:R:W91	11.02	Yes	Yes	0	5	4
97	R:R:F95	R:R:W93	10.02	No	Yes	0	7	9
98	R:R:C100	R:R:W93	9.14	Yes	Yes	8	9	9
99	R:R:M103	R:R:W93	4.65	No	Yes	0	5	9
100	R:R:C177	R:R:W93	13.06	No	Yes	8	9	9
101	R:R:D97	R:R:R101	13.1	No	No	0	3	6
102	R:R:D97	R:R:P168	8.05	No	No	0	3	4
103	R:R:I98	R:R:P99	3.39	No	No	0	2	5
104	R:R:I98	R:R:R101	5.01	No	No	0	2	6
105	R:R:C100	R:R:M167	3.24	Yes	No	0	9	3
106	R:R:C100	R:R:P168	3.77	Yes	No	0	9	4
107	R:R:C100	R:R:C177	7.28	Yes	No	8	9	9
108	L:L:?1	R:R:L104	10.92	Yes	No	0	0	5
109	R:R:F105	R:R:M109	11.2	No	Yes	9	6	5
110	R:R:F105	R:R:T159	6.49	No	Yes	9	6	7
111	R:R:F105	R:R:L163	14.61	No	No	0	6	5
112	R:R:L107	R:R:Y284	3.52	Yes	Yes	1	6	7
113	L:L:?1	R:R:L107	6.07	Yes	Yes	1	0	6
114	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
115	R:R:M109	R:R:T159	4.52	Yes	Yes	9	5	7
116	R:R:E196	R:R:R111	4.65	No	No	0	5	8
117	R:R:R111	R:R:T283	5.17	No	Yes	0	8	8
118	L:L:?1	R:R:R111	10.65	Yes	No	0	0	8
119	R:R:L158	R:R:Q112	6.65	No	No	0	5	7
120	R:R:M192	R:R:Q112	10.88	No	No	0	5	7
121	R:R:E196	R:R:Q112	12.74	No	No	0	5	7
122	R:R:G113	R:R:T155	3.64	No	Yes	0	7	7
123	R:R:E196	R:R:I115	5.47	No	No	0	5	8
124	R:R:I115	R:R:P200	3.39	No	No	0	8	9
125	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
126	R:R:I116	R:R:L151	4.28	No	No	0	5	7
127	R:R:I116	R:R:T155	7.6	No	Yes	0	5	7
128	R:R:F117	R:R:L151	8.53	No	No	0	8	7
129	R:R:F117	R:R:W152	5.01	No	Yes	7	8	9
130	R:R:P200	R:R:T119	3.5	No	No	0	9	7
131	R:R:I203	R:R:T119	6.08	No	No	0	7	7
132	R:R:R125	R:R:V121	5.23	No	No	0	9	9
133	R:R:D124	R:R:R128	9.53	No	Yes	6	8	8
134	R:R:R125	R:R:Y294	6.17	No	Yes	0	9	9
135	R:R:F127	R:R:Y126	5.16	Yes	Yes	3	5	7
136	R:R:V130	R:R:Y126	13.88	Yes	Yes	3	8	7
137	R:R:H131	R:R:Y126	7.62	Yes	Yes	3	7	7
138	R:R:F206	R:R:Y126	4.13	No	Yes	3	4	7
139	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
140	R:R:R210	R:R:Y126	6.17	No	Yes	3	4	7
141	R:R:F127	R:R:H131	3.39	Yes	Yes	3	5	7
142	R:R:F127	R:R:H134	11.31	Yes	No	0	5	4
143	R:R:F127	R:R:L136	3.65	Yes	No	0	5	4
144	R:R:N137	R:R:R128	4.82	No	Yes	0	4	8
145	R:R:I211	R:R:V129	6.14	No	No	0	8	8
146	R:R:L215	R:R:V129	4.47	No	No	0	8	8
147	R:R:H131	R:R:V130	8.3	Yes	Yes	3	7	8
148	R:R:R210	R:R:V130	5.23	No	Yes	3	4	8
149	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
150	R:R:H133	R:R:P132	4.58	No	No	0	6	8
151	R:R:T155	R:R:W152	3.64	Yes	Yes	0	7	9
152	R:R:G157	R:R:I156	3.53	No	No	0	5	4
153	R:R:G157	R:R:V160	3.68	No	No	0	5	4
154	R:R:L158	R:R:W188	5.69	No	Yes	0	5	5
155	R:R:H161	R:R:L162	6.43	Yes	No	1	7	4
156	R:R:H161	R:R:W188	8.46	Yes	Yes	0	7	5
157	R:R:H161	R:R:H189	3.58	Yes	Yes	1	7	5
158	R:R:H189	R:R:L162	5.14	Yes	No	1	5	4
159	R:R:I169	R:R:L176	4.28	No	Yes	0	1	4
160	R:R:N175	R:R:Q170	6.6	No	No	0	4	1
161	R:R:L176	R:R:S178	6.01	Yes	No	1	4	4
162	R:R:S178	R:R:S181	4.89	No	No	0	4	4
163	R:R:H189	R:R:S179	9.76	Yes	No	0	5	4
164	R:R:F180	R:R:H189	11.31	Yes	Yes	1	3	5
165	R:R:E190	R:R:F180	3.5	Yes	Yes	1	4	3
166	R:R:F180	R:R:F193	10.72	Yes	No	1	3	6
167	R:R:F180	R:R:R251	4.28	Yes	Yes	1	3	5
168	R:R:F180	R:R:F276	7.5	Yes	Yes	1	3	4
169	R:R:F180	R:R:L280	3.65	Yes	No	1	3	5
170	L:L:?1	R:R:F180	12.81	Yes	Yes	1	0	3
171	R:R:I182	R:R:Y269	4.84	No	Yes	0	3	2
172	R:R:D273	R:R:I182	9.8	No	No	0	4	3
173	R:R:H184	R:R:L258	7.71	No	No	0	3	3
174	R:R:G262	R:R:H184	3.18	No	No	0	4	3
175	R:R:H184	R:R:T263	5.48	No	No	0	3	3
176	R:R:E190	R:R:Q187	6.37	Yes	No	0	4	2
177	R:R:M192	R:R:W188	9.31	No	Yes	0	5	5
178	R:R:E190	R:R:R251	12.79	Yes	Yes	1	4	5
179	R:R:E190	R:R:F255	8.16	Yes	No	1	4	5
180	R:R:F193	R:R:S247	3.96	No	No	0	6	6
181	R:R:F193	R:R:R251	3.21	No	Yes	1	6	5
182	R:R:F255	R:R:L194	4.87	No	No	0	5	4
183	R:R:F197	R:R:F198	5.36	Yes	No	4	8	5
184	R:R:F197	R:R:L201	4.87	Yes	Yes	4	8	7
185	R:R:F197	R:R:F240	4.29	Yes	Yes	4	8	9
186	R:R:F197	R:R:L245	7.31	Yes	No	0	8	6
187	R:R:F197	R:R:V248	6.55	Yes	No	4	8	8
188	R:R:F198	R:R:V248	3.93	No	No	4	5	8
189	R:R:L199	R:R:P200	4.93	No	No	0	4	9
190	R:R:L201	R:R:L205	5.54	Yes	No	0	7	4
191	R:R:F240	R:R:L201	3.65	Yes	Yes	4	9	7
192	R:R:F240	R:R:I204	5.02	Yes	No	0	9	8
193	R:R:F206	R:R:R210	7.48	No	No	3	4	4
194	R:R:I211	R:R:I233	4.42	No	Yes	0	8	7
195	R:R:I212	R:R:I230	4.42	Yes	No	0	5	6
196	R:R:I212	R:R:I233	5.89	Yes	Yes	0	5	7
197	R:R:I212	R:R:M234	4.37	Yes	No	0	5	4
198	R:R:Q217	R:R:W213	3.29	No	No	0	5	3
199	R:R:L215	R:R:M220	4.24	No	No	0	8	3
200	R:R:D221	R:R:R216	4.76	No	No	0	3	4
201	R:R:M220	R:R:R218	6.2	No	No	0	3	5
202	R:R:H223	R:R:K225	5.24	No	No	0	4	5
203	R:R:H223	R:R:I226	3.98	No	No	0	4	6
204	R:R:F232	R:R:R228	5.34	Yes	No	0	7	7
205	R:R:F232	R:R:T231	5.19	Yes	No	0	7	6
206	R:R:F232	R:R:V235	3.93	Yes	No	0	7	5
207	R:R:F232	R:R:S297	13.21	Yes	No	0	7	6
208	R:R:V235	R:R:V293	4.81	No	No	0	5	8
209	R:R:V236	R:R:Y294	10.09	No	Yes	0	8	9
210	R:R:F240	R:R:F244	5.36	Yes	Yes	0	9	8
211	R:R:L245	R:R:V241	4.47	No	No	0	6	5
212	R:R:C243	R:R:M285	4.86	No	No	0	8	5
213	R:R:C243	R:R:N286	3.15	No	Yes	0	8	9
214	R:R:F244	R:R:T283	3.89	Yes	Yes	0	8	8
215	R:R:F244	R:R:N286	8.46	Yes	Yes	0	8	9
216	R:R:P246	R:R:T279	3.5	No	No	0	9	7
217	R:R:S247	R:R:T279	3.2	No	No	0	6	7
218	R:R:F276	R:R:V250	5.24	Yes	No	0	4	5
219	R:R:T279	R:R:V250	4.76	No	No	0	7	5
220	R:R:I254	R:R:R251	3.76	No	Yes	0	4	5
221	R:R:F255	R:R:R251	4.28	No	Yes	1	5	5
222	R:R:F276	R:R:R251	16.03	Yes	Yes	1	4	5
223	R:R:L257	R:R:R253	10.93	No	No	0	3	5
224	R:R:R253	R:R:V272	3.92	No	No	0	5	4
225	R:R:T260	R:R:W256	8.49	No	No	0	1	4
226	R:R:L257	R:R:Y269	4.69	No	Yes	0	3	2
227	R:R:L258	R:R:Y269	4.69	No	Yes	0	3	2
228	R:R:S261	R:R:T260	3.2	No	No	0	3	1
229	R:R:G262	R:R:S261	3.71	No	No	0	4	3
230	R:R:G262	R:R:Q264	4.93	No	No	0	4	3
231	R:R:N265	R:R:Q264	7.92	No	No	0	5	3
232	R:R:E267	R:R:R270	8.14	No	No	0	2	1
233	R:R:V268	R:R:Y269	8.83	No	Yes	0	1	2
234	R:R:D273	R:R:F277	7.17	No	Yes	0	4	5
235	R:R:F276	R:R:F277	8.57	Yes	Yes	0	4	5
236	R:R:F276	R:R:L280	4.87	Yes	No	1	4	5
237	L:L:?1	R:R:F277	3.2	Yes	Yes	0	0	5
238	R:R:L280	R:R:T283	5.9	No	Yes	0	5	8
239	R:R:T283	R:R:Y284	4.99	Yes	Yes	0	8	7
240	L:L:?1	R:R:Y284	6.17	Yes	Yes	1	0	7
241	R:R:M285	R:R:M288	4.33	No	No	0	5	8
242	R:R:D290	R:R:N286	10.77	Yes	Yes	0	9	9
243	R:R:D290	R:R:Y294	5.75	Yes	Yes	2	9	9
244	R:R:P291	R:R:Y295	4.17	Yes	Yes	0	9	7
245	R:R:F296	R:R:P291	4.33	Yes	Yes	0	8	9
246	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
247	R:R:P299	R:R:S298	3.56	No	No	0	5	8
248	R:R:I233	R:R:S208	3.1	Yes	No	0	7	8
249	R:R:I278	R:R:V29	3.07	No	No	0	6	5
250	R:R:M109	R:R:T155	3.01	Yes	Yes	0	5	7
251	R:R:M192	R:R:T159	3.01	No	Yes	0	5	7
252	R:R:L30	R:R:V29	2.98	Yes	No	0	5	5
253	R:R:L289	R:R:V239	2.98	No	No	0	7	7
254	R:R:L245	R:R:V249	2.98	No	No	0	6	6
255	R:R:I226	R:R:I230	2.94	No	No	0	6	6
256	R:R:I78	R:R:M106	2.92	No	No	0	6	5
257	R:R:F282	R:R:P246	2.89	No	No	0	7	9
258	R:R:I13	R:R:L11	2.85	No	No	0	3	8
259	R:R:I26	R:R:L274	2.85	No	No	0	5	1
260	R:R:I147	R:R:L151	2.85	No	No	0	5	7
261	R:R:I154	R:R:L158	2.85	No	No	0	5	5
262	R:R:I278	R:R:L274	2.85	No	No	0	6	1
263	R:R:L36	R:R:M288	2.83	No	No	0	4	8
264	R:R:L289	R:R:M285	2.83	No	No	0	7	5
265	R:R:C266	R:R:F10	2.79	No	Yes	0	7	7
266	R:R:C19	R:R:F21	2.79	No	No	0	4	2
267	R:R:C53	R:R:F67	2.79	No	Yes	0	4	6
268	R:R:P31	R:R:Y87	2.78	Yes	Yes	0	6	6
269	R:R:A48	R:R:F296	2.77	No	Yes	0	9	8
270	R:R:A144	R:R:F65	2.77	No	No	0	7	7
271	R:R:A191	R:R:F186	2.77	No	No	0	3	4
272	R:R:L118	R:R:N286	2.75	No	Yes	0	9	9
273	R:R:H55	R:R:I51	2.65	No	No	0	5	7
274	R:R:R63	R:R:S300	2.64	No	No	0	7	5
275	R:R:R90	R:R:V27	2.62	No	No	0	4	3
276	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
277	R:R:H161	R:R:K165	2.62	Yes	No	0	7	4
278	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
279	R:R:H134	R:R:N137	2.55	No	No	0	4	4
280	R:R:I233	R:R:R125	2.51	Yes	No	0	7	9
281	R:R:F198	R:R:I252	2.51	No	No	0	5	6
282	R:R:I212	R:R:R216	2.51	Yes	No	0	5	4
283	R:R:F25	R:R:K28	2.48	No	No	0	6	3
284	R:R:K94	R:R:R89	2.48	No	No	0	3	4
285	R:R:K166	R:R:R101	2.48	No	No	0	4	6
286	R:R:F296	R:R:L47	2.44	Yes	No	0	8	6
287	R:R:D124	R:R:F65	2.39	No	No	0	8	7
288	R:R:L80	R:R:Y284	2.34	No	Yes	0	8	7
289	R:R:F10	R:R:H9	2.26	Yes	No	0	7	6
290	R:R:G172	R:R:G173	2.11	No	No	0	3	4
291	R:R:G96	R:R:P99	2.03	No	No	0	7	5
292	R:R:A122	R:R:C207	1.81	No	No	0	9	8
293	R:R:G44	R:R:L43	1.71	No	No	0	7	4
294	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
295	R:R:A237	R:R:S208	1.71	No	No	0	7	8
296	R:R:G46	R:R:N45	1.7	No	No	0	4	9
297	R:R:A108	R:R:T159	1.68	No	Yes	0	4	7
298	R:R:S298	R:R:S300	1.63	No	No	0	8	5
299	R:R:S281	R:R:V33	1.62	No	No	0	6	5
300	R:R:S140	R:R:T143	1.6	No	No	0	6	3
301	R:R:V235	R:R:V239	1.6	No	No	0	5	7
302	R:R:V236	R:R:V293	1.6	No	No	0	8	8
303	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
304	R:R:I139	R:R:T143	1.52	No	No	0	7	3
305	R:R:I238	R:R:I242	1.47	No	No	0	5	5
306	R:R:A224	R:R:H223	1.46	No	No	0	3	4
307	R:R:I238	R:R:M234	1.46	No	No	0	5	4
308	R:R:K164	R:R:K165	1.44	No	No	0	4	4
309	R:R:I98	R:R:L102	1.43	No	No	0	2	5
310	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
311	R:R:F296	R:R:V292	1.31	Yes	No	0	8	6
312	R:R:A191	R:R:W188	1.3	No	Yes	0	3	5
313	R:R:S214	R:R:W213	1.24	No	No	0	5	3
314	R:R:V71	R:R:W152	1.23	No	Yes	0	6	9
315	R:R:D221	R:R:R222	1.19	No	No	0	3	3
316	R:R:Q219	R:R:R222	1.17	No	No	0	3	3
317	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F10	4.845	4	5	7
2	R:R:N17	11.8925	4	5	5
3	R:R:R22	6.4425	4	0	3
4	R:R:L30	6.3125	4	1	5
5	R:R:P31	3.875	4	0	6
6	R:R:F38	6.7725	4	0	7
7	R:R:F67	5.9725	4	0	6
8	R:R:L69	4.0875	4	2	9
9	R:R:D73	7	5	2	9
10	R:R:L83	5.288	5	1	6
11	R:R:Y87	5.302	5	1	6
12	R:R:W91	6.422	5	1	4
13	R:R:W93	7.65167	6	8	9
14	R:R:C100	5.8575	4	8	9
15	R:R:L107	6.1625	4	1	6
16	R:R:M109	5.775	4	9	5
17	R:R:Y126	7.72833	6	3	7
18	R:R:F127	5.226	5	3	5
19	R:R:R128	6.5525	4	6	8
20	R:R:V130	8.4675	4	3	8
21	R:R:H131	5.21	4	3	7
22	R:R:W152	3.255	6	7	9
23	R:R:T155	4.4725	4	0	7
24	R:R:T159	3.925	4	9	7
25	R:R:H161	5.2725	4	1	7
26	R:R:L176	5.29	4	1	4
27	R:R:F180	7.68143	7	1	3
28	R:R:W188	6.19	4	0	5
29	R:R:H189	7.4475	4	1	5
30	R:R:E190	7.705	4	1	4
31	R:R:F197	5.676	5	4	8
32	R:R:L201	3.9425	4	4	7
33	R:R:I212	4.2975	4	0	5
34	R:R:F232	6.9175	4	0	7
35	R:R:I233	3.98	4	0	7
36	R:R:F240	4.58	4	4	9
37	R:R:F244	6.3125	4	0	8
38	R:R:R251	7.39167	6	1	5
39	R:R:Y269	5.7625	4	0	2
40	R:R:F276	8.442	5	1	4
41	R:R:F277	7.49	4	0	5
42	R:R:T283	4.9875	4	0	8
43	R:R:Y284	4.41286	7	1	7
44	R:R:N286	6.2825	4	0	9
45	R:R:D290	6.81	4	2	9
46	R:R:P291	5.99	4	0	9
47	R:R:Y294	5.50333	6	2	9
48	R:R:Y295	4.64167	6	2	7
49	R:R:F296	2.7125	4	0	8
50	L:L:?1	7.8925	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D273	R:R:F21	12.9578	7.17	No	No	0	4	2
2	R:R:D273	R:R:F277	33.3712	7.17	No	Yes	0	4	5
3	R:R:F277	R:R:W91	19.9489	11.02	Yes	Yes	0	5	4
4	R:R:L176	R:R:W91	28.6454	3.42	Yes	Yes	1	4	4
5	R:R:L176	R:R:V20	23.9355	7.45	Yes	No	0	4	2
6	R:R:N171	R:R:V20	21.6312	4.43	No	No	0	1	2
7	R:R:C100	R:R:W93	10.7757	9.14	Yes	Yes	8	9	9
8	R:R:N86	R:R:W93	21.6879	7.91	No	Yes	0	5	9
9	R:R:N86	R:R:W91	13.6544	7.91	No	Yes	0	5	4
10	L:L:?1	R:R:N86	31.4195	3.61	Yes	No	0	0	5
11	L:L:?1	R:R:F277	33.0787	3.2	Yes	Yes	0	0	5
12	R:R:F276	R:R:F277	16.8699	8.57	Yes	Yes	0	4	5
13	L:L:?1	R:R:Y284	29.1435	6.17	Yes	Yes	1	0	7
14	R:R:F276	R:R:L280	16.9001	4.87	Yes	No	1	4	5
15	R:R:L280	R:R:T283	23.2832	5.9	No	Yes	0	5	8
16	R:R:F244	R:R:T283	92.2502	3.89	Yes	Yes	0	8	8
17	R:R:F244	R:R:N286	100	8.46	Yes	Yes	0	8	9
18	L:L:?1	R:R:R111	33.2488	10.65	Yes	No	0	0	8
19	R:R:R111	R:R:T283	27.6403	5.17	No	Yes	0	8	8
20	R:R:T283	R:R:Y284	42.9096	4.99	Yes	Yes	0	8	7
21	R:R:D290	R:R:N286	93.6221	10.77	Yes	Yes	0	9	9
22	R:R:D290	R:R:L69	31.6659	4.07	Yes	Yes	2	9	9
23	R:R:L69	R:R:Y295	31.6801	4.69	Yes	Yes	2	9	7
24	R:R:D290	R:R:Y294	52.9408	5.75	Yes	Yes	2	9	9
25	R:R:Y294	R:R:Y295	34.1511	3.97	Yes	Yes	2	9	7
26	R:R:F52	R:R:Y295	55.3675	5.16	No	Yes	0	7	7
27	R:R:F52	R:R:F67	54.2844	6.43	No	Yes	0	7	6
28	R:R:F67	R:R:W59	45.5153	11.02	Yes	No	0	6	6
29	R:R:I64	R:R:W59	43.1382	4.7	No	No	0	7	6
30	R:R:A144	R:R:I64	40.5679	6.5	No	No	0	7	7
31	R:R:A144	R:R:F65	39.2775	2.77	No	No	0	7	7
32	R:R:D124	R:R:F65	36.849	2.39	No	No	0	8	7
33	R:R:D124	R:R:R128	34.3798	9.53	No	Yes	6	8	8
34	R:R:E196	R:R:Q112	15.6663	12.74	No	No	0	5	7
35	R:R:M192	R:R:Q112	13.0606	10.88	No	No	0	5	7
36	R:R:M192	R:R:T159	12.6369	3.01	No	Yes	0	5	7
37	R:R:M109	R:R:T159	10.1677	4.52	Yes	Yes	9	5	7
38	R:R:E196	R:R:I115	11.4528	5.47	No	No	0	5	8
39	R:R:R125	R:R:Y294	17.166	6.17	No	Yes	0	9	9
40	R:R:N137	R:R:R128	28.0196	4.82	No	Yes	0	4	8
41	R:R:H134	R:R:N137	26.6937	2.55	No	No	0	4	4
42	R:R:F127	R:R:H134	25.3643	11.31	Yes	No	0	5	4
43	R:R:F127	R:R:Y126	11.9545	5.16	Yes	Yes	3	5	7
44	R:R:I233	R:R:R125	15.9074	2.51	Yes	No	0	7	9
45	R:R:D273	R:R:I182	19.4881	9.8	No	No	0	4	3
46	R:R:H184	R:R:L258	10.6463	7.71	No	No	0	3	3
47	R:R:L258	R:R:Y269	11.9456	4.69	No	Yes	0	3	2
48	R:R:I182	R:R:Y269	18.405	4.84	No	Yes	0	3	2
49	R:R:F240	R:R:F244	10.2882	5.36	Yes	Yes	0	9	8
50	R:R:I212	R:R:I233	10.0578	5.89	Yes	Yes	0	5	7
51	R:R:L83	R:R:Y87	13.1581	3.52	Yes	Yes	1	6	6
52	R:R:L83	R:R:Y284	11.4404	3.52	Yes	Yes	1	6	7
53	R:R:F244	R:R:I115	12.1885	7.54	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L34	R:R:L83	4.15	1	No	Yes	8	6	2	1
R:R:L34	R:R:Y284	5.86	1	No	Yes	8	7	2	1
R:R:E37	R:R:Y284	4.49	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	9.52	0	No	Yes	6	6	2	1
R:R:L83	R:R:Y87	3.52	1	Yes	Yes	6	6	1	2
R:R:L107	R:R:L83	5.54	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L83	9.71	1	Yes	Yes	0	6	0	1
R:R:N86	R:R:W91	7.91	0	No	Yes	5	4	1	2
R:R:N86	R:R:W93	7.91	0	No	Yes	5	9	1	2
L:L:?1	R:R:N86	3.61	1	Yes	No	0	5	0	1
R:R:W91	R:R:Y87	4.82	1	Yes	Yes	4	6	2	2
R:R:F277	R:R:W91	11.02	0	Yes	Yes	5	4	1	2
L:L:?1	R:R:L104	10.92	1	Yes	No	0	5	0	1
R:R:L107	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	6.07	1	Yes	Yes	0	6	0	1
R:R:E196	R:R:R111	4.65	0	No	No	5	8	2	1
R:R:R111	R:R:T283	5.17	0	No	Yes	8	8	1	2
L:L:?1	R:R:R111	10.65	1	Yes	No	0	8	0	1
R:R:F180	R:R:H189	11.31	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	3.5	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	10.72	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	7.5	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	No	3	5	1	2
L:L:?1	R:R:F180	12.81	1	Yes	Yes	0	3	0	1
R:R:E190	R:R:R251	12.79	1	Yes	Yes	4	5	2	2
R:R:F193	R:R:R251	3.21	1	No	Yes	6	5	2	2
R:R:F276	R:R:R251	16.03	1	Yes	Yes	4	5	2	2
R:R:D273	R:R:F277	7.17	0	No	Yes	4	5	2	1
R:R:F276	R:R:F277	8.57	1	Yes	Yes	4	5	2	1
R:R:F276	R:R:L280	4.87	1	Yes	No	4	5	2	2
L:L:?1	R:R:F277	3.2	1	Yes	Yes	0	5	0	1
R:R:L280	R:R:T283	5.9	1	No	Yes	5	8	2	2
R:R:T283	R:R:Y284	4.99	0	Yes	Yes	8	7	2	1
L:L:?1	R:R:Y284	6.17	1	Yes	Yes	0	7	0	1
R:R:L80	R:R:Y284	2.34	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IHI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	277
Number of Links	317
Number of Hubs	50
Number of Links mediated by Hubs	178
Number of Communities	9
Number of Nodes involved in Communities	53
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	83547
Length Of Smallest Path	3
Average Path Length	15.5955
Length of Longest Path	34
Minimum Path Strength	1.18
Average Path Strength	6.07335
Maximum Path Strength	19.62
Minimum Path Correlation	0.7
Average Path Correlation	0.917822
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	41.6491
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.5992
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • intracellular protein localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • periplasmic space • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • synapse • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • myelin sheath • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • peptide secretion • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	P9X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P9X
Name	(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
Synonyms	Acifran
Identifier
Formula	C12 H10 O4
Molecular Weight	218.205
SMILES
PubChem	76969700
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IHI_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IHI_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.