Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.2061010
2R:R:K16 9.832534
3R:R:L30 4.12505
4R:R:L34 5.878518
5R:R:E37 6.63417
6R:R:I64 2.815407
7R:R:F65 7.02427
8R:R:N68 5.05409
9R:R:L80 6.21518
10R:R:L83 5.065416
11R:R:W91 4.885614
12R:R:W93 9.54571719
13R:R:I98 4.3725402
14R:R:P99 4.32415
15R:R:L107 8.312516
16R:R:M109 4.8225405
17R:R:R111 5.295618
18R:R:Q112 5.2475477
19R:R:F117 10.765428
20R:R:Y126 5.4697
21R:R:H131 5.575497
22R:R:S179 4.375414
23R:R:F180 7.95713
24R:R:I182 5.15254103
25R:R:E190 6.0975414
26R:R:F197 6.124588
27R:R:C207 3.3975408
28R:R:F232 4.265407
29R:R:F244 6.672588
30R:R:L245 2.85406
31R:R:R251 6.62515
32R:R:T263 1.5525443
33R:R:Y269 4.1265102
34R:R:D273 7.9675404
35R:R:F276 7.6175404
36R:R:L280 7.645415
37R:R:Y284 7.88333617
38R:R:D290 6.2825429
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:W91 22.10255.37YesYes104
2L:L:?1 R:R:S178 13.81113.54YesNo104
3R:R:S178 R:R:S181 15.67093.26NoNo044
4R:R:C183 R:R:S181 13.75371.72NoNo014
5L:L:?1 R:R:F180 10.236115.79YesYes103
6R:R:F180 R:R:F276 11.58589.65YesYes034
7R:R:L30 R:R:Y87 11.54337.03YesNo056
8L:L:?1 R:R:L83 16.79744.89YesYes106
9R:R:L80 R:R:L83 11.03744.15YesYes186
10R:R:L34 R:R:L80 16.391412.46YesYes188
11L:L:?1 R:R:Y284 30.45979.67YesYes107
12R:R:L80 R:R:Y284 19.25235.86YesYes187
13R:R:E37 R:R:Y284 15.21827.86YesYes177
14R:R:E37 R:R:L34 12.35957.95YesYes178
15R:R:G35 R:R:L34 24.93573.42NoYes058
16R:R:F38 R:R:G35 23.47553.01NoNo075
17R:R:F38 R:R:L42 20.54243.65NoNo077
18R:R:F74 R:R:L42 19.06953.65NoNo077
19R:R:F74 R:R:N45 16.321316.92NoNo679
20R:R:G46 R:R:N45 14.8593.39NoNo049
21R:R:G46 R:R:L47 13.3691.71NoNo046
22R:R:T283 R:R:Y284 55.00017.49NoYes087
23R:R:F244 R:R:T283 1003.89YesNo088
24R:R:F244 R:R:I115 85.92116.28YesNo088
25R:R:E196 R:R:I115 57.941712.3NoNo058
26R:R:E196 R:R:Q112 57.13625.1NoYes057
27R:R:Q112 R:R:T155 54.6944.25YesNo077
28R:R:M109 R:R:T155 53.04473.01YesNo057
29R:R:M109 R:R:W152 49.6954.65YesNo059
30R:R:N68 R:R:W152 47.96283.39YesNo099
31L:L:?1 R:R:R111 23.87728.59YesYes108
32R:R:R111 R:R:T283 45.93937.76YesNo088
33R:R:I64 R:R:N68 42.87664.25YesYes079
34R:R:F65 R:R:I64 34.14313.77YesYes077
35R:R:F117 R:R:F65 25.690213.93YesYes287
36R:R:F117 R:R:L69 19.949413.4YesNo289
37R:R:D290 R:R:L69 17.9434.07YesNo299
38R:R:L83 R:R:M103 31.85837.07YesNo065
39R:R:M103 R:R:W93 30.38964.65NoYes059
40R:R:F95 R:R:W93 13.460420.04NoYes179
41R:R:D85 R:R:F95 11.36698.36NoNo047
42R:R:N86 R:R:W91 16.96323.39NoYes154
43R:R:N86 R:R:W93 14.66987.91NoYes159
44R:R:P99 R:R:W93 21.00154.05YesYes159
45R:R:I98 R:R:P99 16.54233.39YesYes025
46R:R:I115 R:R:P200 37.42483.39NoNo089
47R:R:L199 R:R:P200 36.5134.93NoNo049
48R:R:I203 R:R:L199 34.67667.14NoNo074
49R:R:C207 R:R:I203 29.06541.64YesNo087
50R:R:C207 R:R:Y126 24.16636.72YesYes087
51R:R:I211 R:R:Y126 13.32652.42NoYes087
52R:R:I211 R:R:V129 11.394510.75NoNo088
53R:R:L215 R:R:V129 10.36794.47NoNo088
54R:R:E190 R:R:H189 13.87066.15YesNo145
55R:R:E190 R:R:Q187 11.11398.92YesNo042
56R:R:F197 R:R:F244 15.52426.43YesYes888
57R:R:D290 R:R:V293 15.1822.92YesNo098
58R:R:F232 R:R:V293 13.35635.24YesNo078
59R:R:L107 R:R:L83 12.85044.15YesYes166
60R:R:F180 R:R:R111 14.51684.28YesYes138
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L83 4.89 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y87 9.67 1 Yes No 0 6 0 1
L:L:?1 R:R:W91 5.37 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L107 19.58 1 Yes Yes 0 6 0 1
L:L:?1 R:R:R111 8.59 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S178 3.54 1 Yes No 0 4 0 1
L:L:?1 R:R:S179 3.54 1 Yes Yes 0 4 0 1
L:L:?1 R:R:F180 15.79 1 Yes Yes 0 3 0 1
L:L:?1 R:R:L280 11.42 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y284 9.67 1 Yes Yes 0 7 0 1
R:R:R22 R:R:W91 4 0 No Yes 3 4 2 1
R:R:L30 R:R:Y87 7.03 0 Yes No 5 6 2 1
R:R:E37 R:R:L80 5.3 1 Yes Yes 7 8 2 2
R:R:E37 R:R:Y284 7.86 1 Yes Yes 7 7 2 1
R:R:C79 R:R:L107 4.76 0 No Yes 6 6 2 1
R:R:L80 R:R:L83 4.15 1 Yes Yes 8 6 2 1
R:R:L80 R:R:Y284 5.86 1 Yes Yes 8 7 2 1
R:R:L83 R:R:M103 7.07 1 Yes No 6 5 1 2
R:R:L107 R:R:L83 4.15 1 Yes Yes 6 6 1 1
R:R:N86 R:R:W91 3.39 1 No Yes 5 4 2 1
R:R:W91 R:R:Y87 4.82 1 Yes No 4 6 1 1
R:R:S178 R:R:W91 3.71 1 No Yes 4 4 1 1
R:R:F277 R:R:W91 8.02 0 No Yes 5 4 2 1
R:R:L104 R:R:S179 4.5 0 No Yes 5 4 2 1
R:R:L107 R:R:R111 4.86 1 Yes Yes 6 8 1 1
R:R:L107 R:R:Y284 8.21 1 Yes Yes 6 7 1 1
R:R:F180 R:R:R111 4.28 1 Yes Yes 3 8 1 1
R:R:L280 R:R:R111 3.64 1 Yes Yes 5 8 1 1
R:R:R111 R:R:T283 7.76 1 Yes No 8 8 1 2
R:R:S178 R:R:S181 3.26 1 No No 4 4 1 2
R:R:F180 R:R:S179 5.28 1 Yes Yes 3 4 1 1
R:R:H189 R:R:S179 4.18 1 No Yes 5 4 2 1
R:R:F180 R:R:H189 9.05 1 Yes No 3 5 1 2
R:R:F180 R:R:F193 4.29 1 Yes No 3 6 1 2
R:R:F180 R:R:F276 9.65 1 Yes Yes 3 4 1 2
R:R:F180 R:R:L280 7.31 1 Yes Yes 3 5 1 1
R:R:L280 R:R:Y284 8.21 1 Yes Yes 5 7 1 1
R:R:T283 R:R:Y284 7.49 0 No Yes 8 7 2 1
R:R:R111 R:R:S114 2.64 1 Yes No 8 9 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JHN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.01
Number of Linked Nodes 277
Number of Links 313
Number of Hubs 38
Number of Links mediated by Hubs 143
Number of Communities 10
Number of Nodes involved in Communities 55
Number of Links involved in Communities 74
Path Summary
Number Of Nodes in MetaPath 61
Number Of Links MetaPath 60
Number of Shortest Paths 75566
Length Of Smallest Path 3
Average Path Length 14.9884
Length of Longest Path 36
Minimum Path Strength 1.19
Average Path Strength 5.83252
Maximum Path Strength 19.16
Minimum Path Correlation 0.7
Average Path Correlation 0.927168
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 45.6794
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.3825
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • mu-type opioid receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • opioid receptor binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cation binding   • metal ion binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • behavior   • locomotory behavior   • transport   • secretion   • export from cell   • membrane docking   • establishment of localization   • vesicle-mediated transport   • localization   • organelle localization by membrane tethering   • secretion by cell   • exocytosis   • organelle localization   • vesicle docking   • exocytic process   • vesicle docking involved in exocytosis   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • protein localization   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • negative regulation of secretion   • cellular macromolecule localization   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • postsynaptic modulation of chemical synaptic transmission   • muscle contraction   • muscle system process   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • parallel fiber to Purkinje cell synapse   • excitatory synapse   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • GABA-ergic synapse   • glutamatergic synapse   • cell body   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • neurotransmitter receptor activity   • G protein-coupled amine receptor activity   • G protein-coupled acetylcholine receptor activity   • postsynaptic neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • acetylcholine receptor activity   • nicotinic acid receptor activity   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway   • cell surface receptor signaling pathway   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • regulation of locomotion   • locomotion   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • myeloid cell apoptotic process   • homeostatic process   • leukocyte apoptotic process   • cell death   • neutrophil homeostasis   • neutrophil apoptotic process   • multicellular organismal-level homeostasis   • leukocyte homeostasis   • immune system process   • inflammatory cell apoptotic process   • homeostasis of number of cells   • apoptotic process   • myeloid cell homeostasis   • programmed cell death   • protein localization   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of adiponectin secretion   • positive regulation of establishment of protein localization   • positive regulation of adiponectin secretion   • localization   • adiponectin secretion   • cellular macromolecule localization   • regulation of biological quality   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • endocrine hormone secretion   • positive regulation of protein localization   • positive regulation of multicellular organismal process   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • transport   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • secretion by cell   • regulation of secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • signal release   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of signaling   • secretion   • regulation of transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • positive regulation of protein secretion   • endocrine process   • positive regulation of transport   • protein transport   • regulation of cellular localization   • macromolecule localization   • hormone transport   • regulation of cell communication   • positive regulation of signaling   • regulation of programmed cell death   • regulation of neutrophil apoptotic process   • positive regulation of myeloid cell apoptotic process   • positive regulation of neutrophil apoptotic process   • regulation of immune system process   • positive regulation of leukocyte apoptotic process   • positive regulation of immune system process   • regulation of leukocyte apoptotic process   • positive regulation of programmed cell death   • regulation of apoptotic process   • positive regulation of apoptotic process   • regulation of myeloid cell apoptotic process   • negative regulation of catabolic process   • lipid catabolic process   • catabolic process   • regulation of lipid metabolic process   • negative regulation of metabolic process   • negative regulation of biological process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • negative regulation of cellular process   • metabolic process   • regulation of metabolic process   • negative regulation of lipid metabolic process   • negative regulation of lipid catabolic process   • lipid metabolic process   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUR9
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeUR9
NameMonomethyl fumarate
Synonyms(E)-4-methoxy-4-oxidanylidene-but-2-enoic acid
Identifier
FormulaC5 H6 O4
Molecular Weight130.099
SMILES
PubChem5369209
Formal Charge0
Total Atoms15
Total Chiral Atoms0
Total Bonds14
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDS4
Sequence
>8JHN_nogp_Chain_R
DHFLEIDKK NCCVFRDDF IVKVLPPVL GLEFIFGLL GNGLALWIF 
KSSRIFLFN LAVADFLLI ICLPFLMDN YVRRWDWKF GDIPCRLML 
FMLAMNRQG SIIFLTVVA VDRYFRVVH PHHALNSNR TAAIISCLL 
WGITIGLTV HLLKKKMPI QNGGANLCS SFSICHTFQ WHEAMFLLE 
FFLPLGIIL FCSARIIWS LRQRQMDRH AKIKRAITF IMVVAIVFV 
ICFLPSVVV RIRIFWLLH TSGTQNCEV YRSVDLAFF ITLSFTYMN 
SMLDPVVYY FSSPSFPNF F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J6LAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.052024-04-0310.1016/j.celrep.2023.113406
8J6L (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.052024-04-0310.1016/j.celrep.2023.113406
8J6IAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.922024-04-0310.1016/j.celrep.2023.113406
8J6I (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.922024-04-0310.1016/j.celrep.2023.113406
8JHNAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMMF-Go/β1/γ23.752024-03-0610.1038/s41467-024-46239-2
8JHN (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMMF-3.752024-03-0610.1038/s41467-024-46239-2
8JERAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Go/β1/γ23.452024-03-0610.1038/s41467-024-46239-2
8JER (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-3.452024-03-0610.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Go/β1/γ23.452024-03-0610.1038/s41467-024-46239-2
8IYW (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-3.452024-03-0610.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Go/β1/γ23.32024-03-0610.1038/s41467-024-46239-2
8IYH (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.32024-03-0610.1038/s41467-024-46239-2
8IY9AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Go/β1/γ23.372024-03-0610.1038/s41467-024-46239-2
8IY9 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.372024-03-0610.1038/s41467-024-46239-2
8I7WAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ23.392024-02-0710.1038/s41467-023-42764-8
8I7W (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-3.392024-02-0710.1038/s41467-023-42764-8
8I7VAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ22.772024-02-0710.1038/s41467-023-42764-8
8I7V (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-2.772024-02-0710.1038/s41467-023-42764-8
8J6JAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.82024-01-1010.1016/j.celrep.2023.113406
8J6J (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-2.82024-01-1010.1016/j.celrep.2023.113406
8IJDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.252024-01-0310.1038/s41421-023-00610-7
8IJD (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.252024-01-0310.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ23.232024-01-0310.1038/s41421-023-00610-7
8IJB (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-3.232024-01-0310.1038/s41421-023-00610-7
8IJAAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ22.692024-01-0310.1038/s41421-023-00610-7
8IJA (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-2.692024-01-0310.1038/s41421-023-00610-7
8IJ3AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens--Gi1/β1/γ23.282024-01-0310.1038/s41421-023-00610-7
8IJ3 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens--3.282024-01-0310.1038/s41421-023-00610-7
8J6RAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.762023-12-0610.1038/s41467-023-43537-z
8J6R (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.762023-12-0610.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensβ-HydroxybutyrateCompound 9nGi1/β1/γ22.62023-12-0610.1038/s41467-023-43537-z
8J6Q (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensβ-HydroxybutyrateCompound 9n2.62023-12-0610.1038/s41467-023-43537-z
8J6PAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinCompound 9nGi1/β1/γ22.552023-12-0610.1038/s41467-023-43537-z
8J6P (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinCompound 9n2.552023-12-0610.1038/s41467-023-43537-z
8K5DAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073--3.742023-11-2210.1038/s41467-023-42764-8
8K5CAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox--3.132023-11-2210.1038/s41467-023-42764-8
8K5BAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin--3.432023-11-2210.1038/s41467-023-42764-8
8H2GAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.012023-10-11To be published
8H2G (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.012023-10-11To be published
8JZ7AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.62023-10-0410.1038/s41392-023-01625-y
8JZ7 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.62023-10-0410.1038/s41392-023-01625-y
8IHBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.852023-09-1310.1038/s41467-023-41650-7
8IHB (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-2.852023-09-1310.1038/s41467-023-41650-7
8JIMAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMMF-Gi1/β1/γ22.982023-09-0610.1016/j.molcel.2023.07.030
8JIM (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMMF-2.982023-09-0610.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.52023-09-0610.1016/j.molcel.2023.07.030
8JIL (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.52023-09-0610.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinCompound 9nGi1/β1/γ23.172023-09-0610.1016/j.molcel.2023.07.030
8JII (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinCompound 9n3.172023-09-0610.1016/j.molcel.2023.07.030
8JHYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens-Compound 9nGi1/β1/γ22.872023-09-0610.1016/j.molcel.2023.07.030
8JHY (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens-Compound 9n2.872023-09-0610.1016/j.molcel.2023.07.030
8IHIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ23.112023-08-3010.1038/s41467-023-41650-7
8IHI (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-3.112023-08-3010.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensLUF6283-Gi1/β1/γ23.062023-08-3010.1038/s41467-023-41650-7
8IHH (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensLUF6283-3.062023-08-3010.1038/s41467-023-41650-7
8IHFAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.972023-08-3010.1038/s41467-023-41650-7
8IHF (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.972023-08-3010.1038/s41467-023-41650-7
7ZLYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
7ZL9AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
7XK2AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.12023-02-2210.1038/s41467-023-37177-6
7XK2 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.12023-02-2210.1038/s41467-023-37177-6
8UUJAAlicarboxylic acidHydroxycarboxylic AcidHCA2Mus musculusFCH-2296413-Gi1/β1/γ22.622025-02-2610.1016/j.cell.2024.11.001
8UUJ (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Mus musculusFCH-2296413-2.622025-02-2610.1016/j.cell.2024.11.001
8UTDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-Gi1/β1/γ23.242025-02-2610.1016/j.cell.2024.11.001
8UTD (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-3.242025-02-2610.1016/j.cell.2024.11.001
9IQTAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/β1/γ22.92024-10-02doi.org/10.1016/j.jmb.2024.168795
9IQT (No Gprot) AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-2.92024-10-02doi.org/10.1016/j.jmb.2024.168795




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Download 8JHN_nogp.zip



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