psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	4.48	Yes	Yes	1	0	6
2	L:L:?1	R:R:L104	7.17	Yes	No	0	0	5
3	L:L:?1	R:R:L107	9.86	Yes	No	1	0	6
4	L:L:?1	R:R:A108	7.14	Yes	No	0	0	4
5	L:L:?1	R:R:R111	9.44	Yes	No	1	0	8
6	L:L:?1	R:R:Q112	8.62	Yes	No	1	0	7
7	L:L:?1	R:R:L158	3.59	Yes	Yes	1	0	5
8	L:L:?1	R:R:T159	5.73	Yes	No	0	0	7
9	L:L:?1	R:R:L162	8.07	Yes	No	0	0	4
10	L:L:?1	R:R:S178	3.89	Yes	No	0	0	4
11	L:L:?1	R:R:S179	9.72	Yes	No	1	0	4
12	L:L:?1	R:R:F180	20.51	Yes	Yes	1	0	3
13	L:L:?1	R:R:H189	15.82	Yes	Yes	1	0	5
14	L:L:?1	R:R:M192	10.07	Yes	No	1	0	5
15	L:L:?1	R:R:E196	4.29	Yes	No	1	0	5
16	L:L:?1	R:R:F277	3.94	Yes	Yes	0	0	5
17	L:L:?1	R:R:L280	6.27	Yes	No	0	0	5
18	L:L:?1	R:R:Y284	6.83	Yes	Yes	1	0	7
19	R:R:F10	R:R:N17	8.46	No	No	0	7	5
20	R:R:I13	R:R:L11	8.56	Yes	No	0	3	8
21	R:R:L11	R:R:N171	8.24	No	No	0	8	1
22	R:R:D14	R:R:I13	5.6	No	Yes	0	5	3
23	R:R:C18	R:R:I13	6.55	No	Yes	0	9	3
24	R:R:I13	R:R:I169	8.83	Yes	No	0	3	1
25	R:R:C18	R:R:K16	4.85	No	No	0	9	4
26	R:R:K16	R:R:T185	10.51	No	No	1	4	2
27	R:R:K16	R:R:Q187	10.85	No	No	1	4	2
28	R:R:C18	R:R:C183	7.28	No	No	0	9	1
29	R:R:C19	R:R:C266	7.28	No	No	0	4	7
30	R:R:D273	R:R:F21	7.17	No	No	0	4	2
31	R:R:D92	R:R:R22	3.57	No	Yes	0	4	3
32	R:R:A174	R:R:R22	5.53	No	Yes	0	2	3
33	R:R:D23	R:R:F25	3.58	Yes	No	1	4	6
34	R:R:D23	R:R:L274	8.14	Yes	No	1	4	1
35	R:R:F25	R:R:L274	3.65	No	No	1	6	1
36	R:R:I26	R:R:L30	7.14	No	Yes	1	5	5
37	R:R:I26	R:R:Y87	4.84	No	Yes	1	5	6
38	R:R:R90	R:R:V27	3.92	No	No	0	4	3
39	R:R:L30	R:R:V29	4.47	Yes	No	0	5	5
40	R:R:L30	R:R:Y87	11.72	Yes	Yes	1	5	6
41	R:R:P31	R:R:P32	5.84	Yes	No	0	6	5
42	R:R:P31	R:R:V88	3.53	Yes	No	0	6	3
43	R:R:E37	R:R:L34	3.98	No	No	1	7	8
44	R:R:L34	R:R:Y284	5.86	No	Yes	1	8	7
45	R:R:G35	R:R:M84	3.49	No	No	0	5	7
46	R:R:E37	R:R:Y284	6.73	No	Yes	1	7	7
47	R:R:E37	R:R:M285	9.47	No	Yes	0	7	5
48	R:R:F38	R:R:L42	8.53	No	No	0	7	7
49	R:R:F38	R:R:L80	7.31	No	No	0	7	8
50	R:R:F38	R:R:P81	8.67	No	No	0	7	8
51	R:R:F40	R:R:M288	6.22	No	No	0	6	8
52	R:R:G41	R:R:I77	3.53	No	No	0	8	6
53	R:R:G44	R:R:P291	4.06	No	No	0	7	9
54	R:R:D73	R:R:N45	6.73	Yes	No	0	9	9
55	R:R:N45	R:R:P291	11.4	No	No	0	9	9
56	R:R:I51	R:R:L47	5.71	No	No	0	7	6
57	R:R:F296	R:R:L47	7.31	No	No	0	8	6
58	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
59	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
60	R:R:F74	R:R:L49	3.65	No	No	0	7	7
61	R:R:F54	R:R:W50	13.03	No	No	0	4	4
62	R:R:H55	R:R:W50	6.35	No	No	0	5	4
63	R:R:H55	R:R:I51	3.98	No	No	0	5	7
64	R:R:F52	R:R:R63	4.28	No	Yes	0	7	7
65	R:R:F52	R:R:F67	6.43	No	Yes	0	7	6
66	R:R:F52	R:R:Y295	8.25	No	Yes	0	7	7
67	R:R:C53	R:R:F54	4.19	No	No	0	4	4
68	R:R:L56	R:R:W59	6.83	No	No	0	5	6
69	R:R:I64	R:R:W59	4.7	No	No	0	7	6
70	R:R:F67	R:R:W59	11.02	Yes	No	0	6	6
71	R:R:I139	R:R:S61	6.19	No	No	0	7	6
72	R:R:R63	R:R:S62	3.95	Yes	No	0	7	8
73	R:R:R128	R:R:S62	5.27	No	No	0	8	8
74	R:R:I64	R:R:N141	4.25	No	No	0	7	2
75	R:R:A144	R:R:I64	4.87	No	No	0	7	7
76	R:R:F65	R:R:V120	9.18	No	No	0	7	7
77	R:R:F65	R:R:I147	3.77	No	No	0	7	5
78	R:R:L66	R:R:V121	4.47	No	No	2	8	9
79	R:R:L66	R:R:Y294	4.69	No	Yes	2	8	9
80	R:R:L66	R:R:Y295	5.86	No	Yes	2	8	7
81	R:R:F67	R:R:V71	3.93	Yes	No	0	6	6
82	R:R:F117	R:R:N68	16.92	Yes	No	4	8	9
83	R:R:N68	R:R:S148	8.94	No	No	0	9	8
84	R:R:N68	R:R:W152	5.65	No	Yes	4	9	9
85	R:R:D73	R:R:L69	5.43	Yes	Yes	2	9	9
86	R:R:D290	R:R:L69	4.07	Yes	Yes	2	9	9
87	R:R:L69	R:R:Y294	3.52	Yes	Yes	2	9	9
88	R:R:L69	R:R:Y295	3.52	Yes	Yes	2	9	7
89	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
90	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
91	R:R:D73	R:R:S287	11.78	Yes	No	0	9	8
92	R:R:D290	R:R:D73	7.98	Yes	Yes	2	9	9
93	R:R:F74	R:R:I78	3.77	No	No	0	7	6
94	R:R:L75	R:R:N110	10.98	No	No	0	6	9
95	R:R:L76	R:R:S287	6.01	No	No	0	7	8
96	R:R:C79	R:R:M106	4.86	No	No	0	6	5
97	R:R:L80	R:R:Y284	4.69	No	Yes	0	8	7
98	R:R:F82	R:R:M103	3.73	No	No	0	6	5
99	R:R:L83	R:R:Y87	5.86	Yes	Yes	1	6	6
100	R:R:L83	R:R:M103	4.24	Yes	No	0	6	5
101	R:R:L107	R:R:L83	6.92	No	Yes	1	6	6
102	R:R:N86	R:R:W91	10.17	No	Yes	0	5	4
103	R:R:N86	R:R:W93	6.78	No	Yes	0	5	9
104	R:R:W91	R:R:Y87	8.68	Yes	Yes	0	4	6
105	R:R:K94	R:R:R89	8.66	No	No	0	3	4
106	R:R:S178	R:R:W91	6.18	No	Yes	0	4	4
107	R:R:F277	R:R:W91	10.02	Yes	Yes	0	5	4
108	R:R:D92	R:R:K94	9.68	No	No	0	4	3
109	R:R:F95	R:R:W93	10.02	No	Yes	0	7	9
110	R:R:C100	R:R:W93	10.45	No	Yes	6	9	9
111	R:R:M103	R:R:W93	4.65	No	Yes	0	5	9
112	R:R:C177	R:R:W93	16.98	No	Yes	6	9	9
113	R:R:K94	R:R:N175	5.6	No	No	0	3	4
114	R:R:D97	R:R:R101	4.76	No	No	0	3	6
115	R:R:D97	R:R:P168	14.49	No	No	0	3	4
116	R:R:C100	R:R:C177	7.28	No	No	6	9	9
117	R:R:K166	R:R:R101	8.66	No	No	0	4	6
118	R:R:C177	R:R:L104	4.76	No	No	0	9	5
119	R:R:F105	R:R:M109	8.71	No	No	0	6	5
120	R:R:F105	R:R:T159	6.49	No	No	0	6	7
121	R:R:F105	R:R:L163	10.96	No	No	0	6	5
122	R:R:M106	R:R:N110	5.61	No	No	0	5	9
123	R:R:M109	R:R:W152	3.49	No	Yes	0	5	9
124	R:R:E196	R:R:R111	3.49	No	No	1	5	8
125	R:R:R111	R:R:T283	6.47	No	No	0	8	8
126	R:R:L158	R:R:Q112	5.32	Yes	No	1	5	7
127	R:R:E196	R:R:Q112	15.29	No	No	1	5	7
128	R:R:G113	R:R:T155	3.64	No	No	0	7	7
129	R:R:F244	R:R:I115	6.28	Yes	No	0	8	8
130	R:R:F117	R:R:I116	5.02	Yes	No	4	8	5
131	R:R:I116	R:R:L151	5.71	No	No	4	5	7
132	R:R:F117	R:R:L151	7.31	Yes	No	4	8	7
133	R:R:F117	R:R:W152	10.02	Yes	Yes	4	8	9
134	R:R:P200	R:R:T119	5.25	No	No	0	9	7
135	R:R:I203	R:R:T119	6.08	No	No	0	7	7
136	R:R:R125	R:R:V121	7.85	No	No	2	9	9
137	R:R:V121	R:R:Y294	3.79	No	Yes	2	9	9
138	R:R:D124	R:R:R128	8.34	No	No	0	8	8
139	R:R:R125	R:R:Y294	6.17	No	Yes	2	9	9
140	R:R:V130	R:R:Y126	12.62	Yes	Yes	3	8	7
141	R:R:H131	R:R:Y126	8.71	Yes	Yes	3	7	7
142	R:R:F206	R:R:Y126	6.19	No	Yes	3	4	7
143	R:R:C207	R:R:Y126	8.06	No	Yes	0	8	7
144	R:R:R210	R:R:Y126	9.26	No	Yes	3	4	7
145	R:R:F127	R:R:H131	4.53	Yes	Yes	3	5	7
146	R:R:F127	R:R:H134	10.18	Yes	No	3	5	4
147	R:R:F127	R:R:L136	4.87	Yes	No	3	5	4
148	R:R:N137	R:R:R128	4.82	No	No	0	4	8
149	R:R:I211	R:R:V129	6.14	No	No	0	8	8
150	R:R:L215	R:R:V129	4.47	No	No	0	8	8
151	R:R:H131	R:R:V130	8.3	Yes	Yes	3	7	8
152	R:R:R210	R:R:V130	3.92	No	Yes	3	4	8
153	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
154	R:R:H133	R:R:P132	6.1	No	No	0	6	8
155	R:R:H134	R:R:L136	3.86	No	No	3	4	4
156	R:R:I139	R:R:T143	6.08	No	No	0	7	3
157	R:R:G157	R:R:V160	3.68	No	No	0	5	4
158	R:R:L158	R:R:M192	4.24	Yes	No	1	5	5
159	R:R:H161	R:R:L162	5.14	No	No	0	7	4
160	R:R:H161	R:R:W188	11.64	No	No	0	7	5
161	R:R:H161	R:R:H189	3.58	No	Yes	0	7	5
162	R:R:I169	R:R:M167	5.83	No	No	0	1	3
163	R:R:I169	R:R:L176	11.42	No	No	0	1	4
164	R:R:N175	R:R:Q170	3.96	No	No	0	4	1
165	R:R:L176	R:R:N171	4.12	No	No	0	4	1
166	R:R:H189	R:R:S179	5.58	Yes	No	1	5	4
167	R:R:F180	R:R:F193	8.57	Yes	No	1	3	6
168	R:R:F180	R:R:R251	4.28	Yes	Yes	1	3	5
169	R:R:F180	R:R:F276	8.57	Yes	Yes	1	3	4
170	R:R:I182	R:R:I254	5.89	No	No	0	3	4
171	R:R:I182	R:R:Y269	6.04	No	Yes	0	3	2
172	R:R:D273	R:R:I182	8.4	No	No	0	4	3
173	R:R:H184	R:R:T263	4.11	No	No	0	3	3
174	R:R:Q187	R:R:T185	5.67	No	No	1	2	2
175	R:R:H189	R:R:Q187	4.95	Yes	No	1	5	2
176	R:R:E190	R:R:R251	10.47	No	Yes	1	4	5
177	R:R:E190	R:R:F255	9.33	No	No	1	4	5
178	R:R:F193	R:R:S247	5.28	No	No	0	6	6
179	R:R:F193	R:R:F276	4.29	No	Yes	1	6	4
180	R:R:L194	R:R:V248	4.47	No	No	0	4	8
181	R:R:F255	R:R:L194	3.65	No	No	0	5	4
182	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
183	R:R:F197	R:R:L201	6.09	Yes	No	0	8	7
184	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
185	R:R:F197	R:R:V248	6.55	Yes	No	0	8	8
186	R:R:L201	R:R:L205	4.15	No	No	0	7	4
187	R:R:F206	R:R:R210	7.48	No	No	3	4	4
188	R:R:I211	R:R:I233	4.42	No	Yes	0	8	7
189	R:R:I212	R:R:I230	5.89	Yes	No	0	5	6
190	R:R:I212	R:R:I233	5.89	Yes	Yes	0	5	7
191	R:R:I230	R:R:L215	4.28	No	No	0	6	8
192	R:R:M220	R:R:R218	3.72	No	No	0	3	5
193	R:R:D221	R:R:R222	10.72	No	No	0	3	3
194	R:R:K227	R:R:R222	4.95	No	No	0	4	3
195	R:R:H223	R:R:I226	3.98	No	No	0	4	6
196	R:R:F232	R:R:R228	9.62	No	No	0	7	7
197	R:R:F232	R:R:T231	6.49	No	No	0	7	6
198	R:R:F232	R:R:S297	9.25	No	No	0	7	6
199	R:R:V236	R:R:Y294	8.83	No	Yes	0	8	9
200	R:R:F240	R:R:F244	6.43	No	Yes	0	9	8
201	R:R:F244	R:R:T283	7.78	Yes	No	0	8	8
202	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
203	R:R:P246	R:R:T279	3.5	No	No	0	9	7
204	R:R:F276	R:R:V250	6.55	Yes	No	0	4	5
205	R:R:T279	R:R:V250	6.35	No	No	0	7	5
206	R:R:I254	R:R:R251	7.52	No	Yes	0	4	5
207	R:R:F255	R:R:R251	5.34	No	Yes	1	5	5
208	R:R:F276	R:R:R251	14.97	Yes	Yes	1	4	5
209	R:R:R253	R:R:V272	7.85	No	No	0	5	4
210	R:R:T260	R:R:W256	8.49	No	No	0	1	4
211	R:R:L257	R:R:S261	6.01	No	Yes	8	3	3
212	R:R:L257	R:R:Y269	3.52	No	Yes	8	3	2
213	R:R:L258	R:R:Y269	7.03	No	Yes	0	3	2
214	R:R:G262	R:R:S261	3.71	No	Yes	0	4	3
215	R:R:S261	R:R:Y269	3.82	Yes	Yes	8	3	2
216	R:R:E267	R:R:N265	3.94	No	No	0	2	5
217	R:R:E267	R:R:R270	9.3	No	No	0	2	1
218	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
219	R:R:D273	R:R:F277	5.97	No	Yes	0	4	5
220	R:R:F276	R:R:F277	4.29	Yes	Yes	0	4	5
221	R:R:F276	R:R:L280	6.09	Yes	No	0	4	5
222	R:R:F282	R:R:S281	3.96	No	No	0	7	6
223	R:R:M285	R:R:M288	5.78	Yes	No	0	5	8
224	R:R:L289	R:R:M285	4.24	No	Yes	0	7	5
225	R:R:D290	R:R:N286	12.12	Yes	No	0	9	9
226	R:R:D290	R:R:Y294	5.75	Yes	Yes	2	9	9
227	R:R:F296	R:R:P291	4.33	No	No	0	8	9
228	R:R:F296	R:R:V292	3.93	No	No	0	8	6
229	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
230	R:R:P299	R:R:S298	3.56	No	No	0	5	8
231	R:R:A237	R:R:S208	3.42	No	No	0	7	8
232	R:R:I98	R:R:P99	3.39	No	No	0	2	5
233	R:R:I115	R:R:P200	3.39	No	No	0	8	9
234	R:R:C19	R:R:T263	3.38	No	No	0	4	3
235	R:R:Q217	R:R:W213	3.29	No	No	0	5	3
236	R:R:L199	R:R:P200	3.28	No	No	0	4	9
237	R:R:S298	R:R:S300	3.26	No	No	5	8	5
238	R:R:C243	R:R:M285	3.24	No	Yes	0	8	5
239	R:R:S181	R:R:V20	3.23	No	No	0	4	2
240	R:R:S281	R:R:V33	3.23	No	No	0	6	5
241	R:R:V235	R:R:V293	3.21	No	No	0	5	8
242	R:R:R22	R:R:R90	3.2	Yes	No	0	3	4
243	R:R:S140	R:R:T143	3.2	No	No	0	6	3
244	R:R:S261	R:R:T260	3.2	Yes	No	0	3	1
245	R:R:I233	R:R:S208	3.1	Yes	No	0	7	8
246	R:R:I254	R:R:V272	3.07	No	No	0	4	4
247	R:R:I116	R:R:T155	3.04	No	No	0	5	7
248	R:R:R22	R:R:W91	3	Yes	Yes	0	3	4
249	R:R:L11	R:R:V20	2.98	No	No	0	8	2
250	R:R:L289	R:R:V239	2.98	No	No	0	7	7
251	R:R:L245	R:R:V241	2.98	No	No	0	6	5
252	R:R:L245	R:R:V249	2.98	No	No	0	6	6
253	R:R:I226	R:R:I230	2.94	No	No	0	6	6
254	R:R:I238	R:R:I242	2.94	No	No	0	5	5
255	R:R:I78	R:R:M106	2.92	No	No	0	6	5
256	R:R:I156	R:R:M109	2.92	No	No	0	4	5
257	R:R:I212	R:R:M234	2.92	Yes	No	0	5	4
258	R:R:F282	R:R:P246	2.89	No	No	0	7	9
259	R:R:P299	R:R:R228	2.88	No	No	0	5	7
260	R:R:I26	R:R:L274	2.85	No	No	1	5	1
261	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
262	R:R:I77	R:R:L42	2.85	No	No	0	6	7
263	R:R:I147	R:R:L151	2.85	No	No	0	5	7
264	R:R:L215	R:R:M220	2.83	No	No	0	8	3
265	R:R:C19	R:R:F21	2.79	No	No	0	4	2
266	R:R:P31	R:R:Y87	2.78	Yes	Yes	0	6	6
267	R:R:D23	R:R:D24	2.66	Yes	No	0	4	4
268	R:R:R63	R:R:S298	2.64	Yes	No	5	7	8
269	R:R:R63	R:R:S300	2.64	Yes	No	5	7	5
270	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
271	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
272	R:R:H134	R:R:N137	2.55	No	No	0	4	4
273	R:R:I98	R:R:R101	2.51	No	No	0	2	6
274	R:R:I233	R:R:R125	2.51	Yes	No	0	7	9
275	R:R:I146	R:R:R142	2.51	No	No	0	3	4
276	R:R:I212	R:R:R216	2.51	Yes	No	0	5	4
277	R:R:F240	R:R:L118	2.44	No	No	0	9	9
278	R:R:D85	R:R:F95	2.39	No	No	0	4	7
279	R:R:D221	R:R:R216	2.38	No	No	0	3	4
280	R:R:F10	R:R:H9	2.26	No	No	0	7	6
281	R:R:G172	R:R:G173	2.11	No	No	7	3	4
282	R:R:G96	R:R:P99	2.03	No	No	0	7	5
283	R:R:G157	R:R:I156	1.76	No	No	0	5	4
284	R:R:A144	R:R:S61	1.71	No	No	0	7	6
285	R:R:G202	R:R:L201	1.71	No	No	0	3	7
286	R:R:M84	R:R:P31	1.68	No	Yes	0	7	6
287	R:R:M84	R:R:P81	1.68	No	No	0	7	8
288	R:R:G172	R:R:Q170	1.64	No	No	7	3	1
289	R:R:G173	R:R:Q170	1.64	No	No	7	4	1
290	R:R:C243	R:R:I242	1.64	No	No	0	8	5
291	R:R:A122	R:R:I204	1.62	No	No	0	9	8
292	R:R:A237	R:R:I204	1.62	No	No	0	7	8
293	R:R:V235	R:R:V239	1.6	No	No	0	5	7
294	R:R:V236	R:R:V293	1.6	No	No	0	8	8
295	R:R:V292	R:R:V293	1.6	No	No	0	6	8
296	R:R:I252	R:R:V248	1.54	No	No	0	6	8
297	R:R:K57	R:R:S58	1.53	No	No	0	5	6
298	R:R:K60	R:R:S58	1.53	No	No	0	7	6
299	R:R:K60	R:R:S62	1.53	No	No	0	7	8
300	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
301	R:R:N17	R:R:T263	1.46	No	No	0	5	3
302	R:R:A224	R:R:H223	1.46	No	No	0	3	4
303	R:R:F95	R:R:P99	1.44	No	No	0	7	5
304	R:R:I154	R:R:L158	1.43	No	Yes	0	5	5
305	R:R:L195	R:R:M192	1.41	No	No	0	4	5
306	R:R:A191	R:R:F186	1.39	No	No	0	3	4
307	R:R:D14	R:R:K165	1.38	No	No	0	5	4
308	R:R:R142	R:R:S140	1.32	No	No	0	4	6
309	R:R:E12	R:R:N17	1.31	No	No	0	5	5
310	R:R:H223	R:R:K225	1.31	No	No	0	4	5
311	R:R:F40	R:R:L43	1.22	No	No	0	6	4
312	R:R:D23	R:R:R270	1.19	Yes	No	0	4	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.08	18	1	0
2	R:R:I13	7.385	4	0	3
3	R:R:R22	3.825	4	0	3
4	R:R:D23	3.8925	4	1	4
5	R:R:L30	6.545	4	1	5
6	R:R:P31	3.4575	4	0	6
7	R:R:R63	3.3775	4	5	7
8	R:R:F67	6.2575	4	0	6
9	R:R:L69	4.135	4	2	9
10	R:R:D73	7.268	5	2	9
11	R:R:L83	5.375	4	1	6
12	R:R:Y87	6.776	5	1	6
13	R:R:W91	7.61	5	0	4
14	R:R:W93	9.776	5	6	9
15	R:R:F117	9.8175	4	4	8
16	R:R:Y126	8.968	5	3	7
17	R:R:F127	5.55	4	3	5
18	R:R:V130	7.4225	4	3	8
19	R:R:H131	5.7675	4	3	7
20	R:R:W152	5.4375	4	4	9
21	R:R:L158	3.645	4	1	5
22	R:R:F180	10.4825	4	1	3
23	R:R:H189	7.4825	4	1	5
24	R:R:F197	6.29	4	0	8
25	R:R:I212	4.3025	4	0	5
26	R:R:I233	3.98	4	0	7
27	R:R:F244	7.2375	4	0	8
28	R:R:R251	8.516	5	1	5
29	R:R:S261	4.185	4	8	3
30	R:R:Y269	4.84	5	8	2
31	R:R:F276	7.46	6	1	4
32	R:R:F277	6.055	4	0	5
33	R:R:Y284	6.0275	4	1	7
34	R:R:M285	5.6825	4	0	5
35	R:R:D290	7.48	4	2	9
36	R:R:Y294	5.24571	7	2	9
37	R:R:Y295	4.93333	6	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F277	31.8033	3.94	Yes	Yes	0	0	5
2	R:R:D273	R:R:F277	19.4012	5.97	No	Yes	0	4	5
3	R:R:D273	R:R:F21	10.079	7.17	No	No	0	4	2
4	L:L:?1	R:R:H189	20.082	15.82	Yes	Yes	1	0	5
5	R:R:H189	R:R:Q187	16.9823	4.95	Yes	No	1	5	2
6	R:R:K16	R:R:Q187	14.831	10.85	No	No	1	4	2
7	R:R:C18	R:R:K16	13.8991	4.85	No	No	0	9	4
8	R:R:C18	R:R:I13	11.5925	6.55	No	Yes	0	9	3
9	L:L:?1	R:R:S178	11.1034	3.89	Yes	No	0	0	4
10	R:R:S178	R:R:W91	10.4689	6.18	No	Yes	0	4	4
11	R:R:R22	R:R:W91	21.0072	3	Yes	Yes	0	3	4
12	R:R:D92	R:R:R22	13.4563	3.57	No	Yes	0	4	3
13	R:R:F277	R:R:W91	17.0417	10.02	Yes	Yes	0	5	4
14	L:L:?1	R:R:L83	25.4651	4.48	Yes	Yes	1	0	6
15	R:R:L83	R:R:Y87	15.3399	5.86	Yes	Yes	1	6	6
16	L:L:?1	R:R:Y284	20.6305	6.83	Yes	Yes	1	0	7
17	R:R:E37	R:R:Y284	12.8978	6.73	No	Yes	1	7	7
18	R:R:E37	R:R:M285	12.9011	9.47	No	Yes	0	7	5
19	L:L:?1	R:R:R111	99.0516	9.44	Yes	No	1	0	8
20	R:R:R111	R:R:T283	100	6.47	No	No	0	8	8
21	R:R:F244	R:R:T283	99.8711	7.78	Yes	No	0	8	8
22	R:R:F244	R:R:N286	98.655	8.46	Yes	No	0	8	9
23	R:R:D290	R:R:N286	98.4799	12.12	Yes	No	0	9	9
24	R:R:F296	R:R:L47	10.6837	7.31	No	No	0	8	6
25	R:R:L289	R:R:M285	10.7035	4.24	No	Yes	0	7	5
26	R:R:L289	R:R:V239	10.3698	2.98	No	No	0	7	7
27	R:R:V235	R:R:V239	10.0823	1.6	No	No	0	5	7
28	R:R:D290	R:R:L69	35.3921	4.07	Yes	Yes	2	9	9
29	R:R:L69	R:R:Y295	37.3286	3.52	Yes	Yes	2	9	7
30	R:R:D290	R:R:Y294	54.5884	5.75	Yes	Yes	2	9	9
31	R:R:Y294	R:R:Y295	43.0488	3.97	Yes	Yes	2	9	7
32	R:R:F52	R:R:Y295	76.4978	8.25	No	Yes	0	7	7
33	R:R:F52	R:R:F67	33.026	6.43	No	Yes	0	7	6
34	R:R:F67	R:R:L49	11.8998	3.65	Yes	No	0	6	7
35	R:R:F74	R:R:L49	10.2178	3.65	No	No	0	7	7
36	R:R:F52	R:R:R63	45.9601	4.28	No	Yes	0	7	7
37	R:R:F67	R:R:W59	18.4891	11.02	Yes	No	0	6	6
38	R:R:I64	R:R:W59	15.3432	4.7	No	No	0	7	6
39	R:R:A144	R:R:I64	11.9791	4.87	No	No	0	7	7
40	R:R:A144	R:R:S61	10.2872	1.71	No	No	0	7	6
41	R:R:R63	R:R:S62	33.8819	3.95	Yes	No	0	7	8
42	R:R:R128	R:R:S62	27.4214	5.27	No	No	0	8	8
43	L:L:?1	R:R:T159	21.9226	5.73	Yes	No	0	0	7
44	R:R:F105	R:R:T159	20.8156	6.49	No	No	0	6	7
45	R:R:F105	R:R:M109	18.5817	8.71	No	No	0	6	5
46	R:R:M109	R:R:W152	14.028	3.49	No	Yes	0	5	9
47	R:R:L83	R:R:M103	11.4074	4.24	Yes	No	0	6	5
48	L:L:?1	R:R:L104	11.5958	7.17	Yes	No	0	0	5
49	R:R:C177	R:R:L104	10.4954	4.76	No	No	0	9	5
50	R:R:D92	R:R:K94	11.5561	9.68	No	No	0	4	3
51	R:R:F95	R:R:W93	18.585	10.02	No	Yes	0	7	9
52	R:R:F95	R:R:P99	14.5005	1.44	No	No	0	7	5
53	R:R:I98	R:R:P99	10.3896	3.39	No	No	0	2	5
54	R:R:R125	R:R:Y294	23.8128	6.17	No	Yes	2	9	9
55	R:R:N137	R:R:R128	24.5266	4.82	No	No	0	4	8
56	R:R:H134	R:R:N137	22.8875	2.55	No	No	0	4	4
57	R:R:F127	R:R:H134	19.5499	10.18	Yes	No	3	5	4
58	R:R:F127	R:R:H131	16.4403	4.53	Yes	Yes	3	5	7
59	R:R:I233	R:R:R125	23.1453	2.51	Yes	No	0	7	9
60	R:R:I212	R:R:I233	13.9387	5.89	Yes	Yes	0	5	7
61	R:R:F276	R:R:F277	10.4755	4.29	Yes	Yes	0	4	5
62	L:L:?1	R:R:F180	24.1102	20.51	Yes	Yes	1	0	3
63	R:R:F180	R:R:R251	16.0041	4.28	Yes	Yes	1	3	5
64	R:R:D273	R:R:I182	10.0691	8.4	No	No	0	4	3
65	R:R:F255	R:R:R251	14.6757	5.34	No	Yes	1	5	5
66	R:R:F255	R:R:L194	13.5191	3.65	No	No	0	5	4
67	R:R:L194	R:R:V248	12.3558	4.47	No	No	0	4	8
68	R:R:R63	R:R:S298	10.0294	2.64	Yes	No	5	7	8
69	R:R:F276	R:R:V250	16.5527	6.55	Yes	No	0	4	5
70	R:R:T279	R:R:V250	13.8099	6.35	No	No	0	7	5
71	R:R:P246	R:R:T279	11.0604	3.5	No	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	4.48	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L104	7.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	9.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	7.14	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	9.44	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q112	8.62	1	Yes	No	0	7	0	1
L:L:?1	R:R:L158	3.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T159	5.73	1	Yes	No	0	7	0	1
L:L:?1	R:R:L162	8.07	1	Yes	No	0	4	0	1
L:L:?1	R:R:S178	3.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	9.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	20.51	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	15.82	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	10.07	1	Yes	No	0	5	0	1
L:L:?1	R:R:E196	4.29	1	Yes	No	0	5	0	1
L:L:?1	R:R:F277	3.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	6.27	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	6.83	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:L34	3.98	1	No	No	7	8	2	2
R:R:L34	R:R:Y284	5.86	1	No	Yes	8	7	2	1
R:R:E37	R:R:Y284	6.73	1	No	Yes	7	7	2	1
R:R:L80	R:R:Y284	4.69	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	5.86	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	4.24	1	Yes	No	6	5	1	2
R:R:L107	R:R:L83	6.92	1	No	Yes	6	6	1	1
R:R:W91	R:R:Y87	8.68	0	Yes	Yes	4	6	2	2
R:R:S178	R:R:W91	6.18	0	No	Yes	4	4	1	2
R:R:F277	R:R:W91	10.02	0	Yes	Yes	5	4	1	2
R:R:C177	R:R:L104	4.76	6	No	No	9	5	2	1
R:R:F105	R:R:T159	6.49	0	No	No	6	7	2	1
R:R:E196	R:R:R111	3.49	1	No	No	5	8	1	1
R:R:R111	R:R:T283	6.47	1	No	No	8	8	1	2
R:R:L158	R:R:Q112	5.32	1	Yes	No	5	7	1	1
R:R:E196	R:R:Q112	15.29	1	No	No	5	7	1	1
R:R:L158	R:R:M192	4.24	1	Yes	No	5	5	1	1
R:R:H161	R:R:L162	5.14	0	No	No	7	4	2	1
R:R:H161	R:R:H189	3.58	0	No	Yes	7	5	2	1
R:R:H189	R:R:S179	5.58	1	Yes	No	5	4	1	1
R:R:F180	R:R:F193	8.57	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	8.57	1	Yes	Yes	3	4	1	2
R:R:H189	R:R:Q187	4.95	1	Yes	No	5	2	1	2
R:R:F193	R:R:F276	4.29	1	No	Yes	6	4	2	2
R:R:F276	R:R:R251	14.97	1	Yes	Yes	4	5	2	2
R:R:D273	R:R:F277	5.97	0	No	Yes	4	5	2	1
R:R:F276	R:R:F277	4.29	1	Yes	Yes	4	5	2	1
R:R:F276	R:R:L280	6.09	1	Yes	No	4	5	2	1
R:R:I154	R:R:L158	1.43	0	No	Yes	5	5	2	1
R:R:L195	R:R:M192	1.41	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IHF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	273
Number of Links	312
Number of Hubs	37
Number of Links mediated by Hubs	146
Number of Communities	8
Number of Nodes involved in Communities	61
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	57432
Length Of Smallest Path	3
Average Path Length	13.969
Length of Longest Path	28
Minimum Path Strength	1.385
Average Path Strength	6.37646
Maximum Path Strength	15.29
Minimum Path Correlation	0.7
Average Path Correlation	0.919637
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.2745
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8456
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • myelin sheath • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • myeloid cell apoptotic process • homeostatic process • leukocyte apoptotic process • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • myeloid cell homeostasis • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • periplasmic space
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FI7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IHF_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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