psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	6.27	Yes	Yes	1	0	6
2	L:L:?1	R:R:L107	7.17	Yes	No	0	0	6
3	L:L:?1	R:R:A108	7.14	Yes	No	1	0	4
4	L:L:?1	R:R:R111	8.65	Yes	Yes	0	0	8
5	L:L:?1	R:R:Q112	6.9	Yes	Yes	1	0	7
6	L:L:?1	R:R:T159	6.68	Yes	No	1	0	7
7	L:L:?1	R:R:S179	9.72	Yes	No	1	0	4
8	L:L:?1	R:R:F180	21.3	Yes	Yes	1	0	3
9	L:L:?1	R:R:H189	14.15	Yes	Yes	1	0	5
10	L:L:?1	R:R:M192	6.41	Yes	No	0	0	5
11	L:L:?1	R:R:E196	11.16	Yes	No	1	0	5
12	L:L:?1	R:R:Y284	5.31	Yes	No	1	0	7
13	R:R:F21	R:R:H9	15.84	Yes	No	0	2	6
14	R:R:H9	R:R:R22	16.93	No	No	0	6	3
15	R:R:E12	R:R:F10	3.5	No	No	5	5	7
16	R:R:F10	R:R:N17	13.29	No	No	5	7	5
17	R:R:I169	R:R:L11	4.28	No	No	0	1	8
18	R:R:L11	R:R:N171	5.49	No	Yes	0	8	1
19	R:R:E12	R:R:N17	6.57	No	No	5	5	5
20	R:R:D14	R:R:I13	5.6	No	No	0	5	3
21	R:R:D14	R:R:Q187	3.92	No	No	0	5	2
22	R:R:K16	R:R:N17	4.2	Yes	No	0	4	5
23	R:R:C183	R:R:K16	3.23	No	Yes	0	1	4
24	R:R:H184	R:R:K16	5.24	Yes	Yes	0	3	4
25	R:R:K16	R:R:T185	12.01	Yes	No	0	4	2
26	R:R:C18	R:R:C183	7.28	No	No	0	9	1
27	R:R:C19	R:R:C266	7.28	No	No	0	4	7
28	R:R:S181	R:R:V20	3.23	No	No	0	4	2
29	R:R:F21	R:R:R270	6.41	Yes	No	0	2	1
30	R:R:D273	R:R:F21	4.78	No	Yes	0	4	2
31	R:R:N171	R:R:R22	4.82	Yes	No	0	1	3
32	R:R:D23	R:R:D24	3.99	No	No	0	4	4
33	R:R:D23	R:R:F25	4.78	No	Yes	0	4	6
34	R:R:D23	R:R:R270	7.15	No	No	0	4	1
35	R:R:F25	R:R:K28	4.96	Yes	No	6	6	3
36	R:R:F25	R:R:V29	5.24	Yes	No	6	6	5
37	R:R:F25	R:R:L274	4.87	Yes	No	0	6	1
38	R:R:I26	R:R:V27	3.07	No	No	0	5	3
39	R:R:I26	R:R:L30	5.71	No	Yes	1	5	5
40	R:R:I26	R:R:Y87	4.84	No	Yes	1	5	6
41	R:R:K28	R:R:V29	3.04	No	No	6	3	5
42	R:R:I278	R:R:V29	6.14	No	No	0	6	5
43	R:R:L30	R:R:L34	12.46	Yes	No	1	5	8
44	R:R:L30	R:R:Y87	7.03	Yes	Yes	1	5	6
45	R:R:L30	R:R:S281	3	Yes	No	0	5	6
46	R:R:P31	R:R:P32	5.84	No	No	0	6	5
47	R:R:L34	R:R:M84	4.24	No	No	0	8	7
48	R:R:L34	R:R:Y87	4.69	No	Yes	1	8	6
49	R:R:E37	R:R:M285	8.12	No	No	0	7	5
50	R:R:E37	R:R:M288	9.47	No	No	0	7	8
51	R:R:F38	R:R:L42	7.31	No	No	0	7	7
52	R:R:F38	R:R:I77	8.79	No	No	0	7	6
53	R:R:F38	R:R:P81	8.67	No	No	0	7	8
54	R:R:F40	R:R:M288	7.46	No	No	0	6	8
55	R:R:F74	R:R:L42	3.65	No	No	0	7	7
56	R:R:G44	R:R:Y295	4.35	No	Yes	0	7	7
57	R:R:D73	R:R:N45	5.39	Yes	Yes	4	9	9
58	R:R:D290	R:R:N45	12.12	Yes	Yes	4	9	9
59	R:R:N45	R:R:P291	3.26	Yes	No	0	9	9
60	R:R:N45	R:R:Y294	6.98	Yes	Yes	4	9	9
61	R:R:F74	R:R:G46	4.52	No	No	0	7	4
62	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
63	R:R:F67	R:R:L49	7.31	Yes	No	0	6	7
64	R:R:F52	R:R:F67	4.29	No	Yes	0	7	6
65	R:R:C53	R:R:F54	4.19	No	No	0	4	4
66	R:R:I64	R:R:W59	10.57	Yes	No	0	7	6
67	R:R:F67	R:R:W59	11.02	Yes	No	0	6	6
68	R:R:K60	R:R:R63	12.38	No	No	0	7	7
69	R:R:R128	R:R:S61	3.95	Yes	No	0	8	6
70	R:R:I139	R:R:S61	6.19	No	No	0	7	6
71	R:R:D124	R:R:S62	4.42	No	No	7	8	8
72	R:R:R128	R:R:S62	7.91	Yes	No	7	8	8
73	R:R:F65	R:R:I64	5.02	No	Yes	0	7	7
74	R:R:A144	R:R:I64	3.25	No	Yes	0	7	7
75	R:R:F65	R:R:V120	3.93	No	No	0	7	7
76	R:R:L66	R:R:Y294	5.86	No	Yes	0	8	9
77	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
78	R:R:F117	R:R:N68	13.29	No	No	8	8	9
79	R:R:N68	R:R:S148	10.43	No	No	0	9	8
80	R:R:N68	R:R:W152	9.04	No	Yes	8	9	9
81	R:R:D290	R:R:L69	6.79	Yes	No	4	9	9
82	R:R:L69	R:R:Y294	5.86	No	Yes	4	9	9
83	R:R:A70	R:R:Y294	5.34	No	Yes	0	8	9
84	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
85	R:R:D73	R:R:S287	7.36	Yes	No	0	9	8
86	R:R:D290	R:R:D73	11.98	Yes	Yes	4	9	9
87	R:R:F74	R:R:I78	5.02	No	No	0	7	6
88	R:R:L75	R:R:N110	8.24	No	No	0	6	9
89	R:R:L107	R:R:L76	4.15	No	No	0	6	7
90	R:R:L76	R:R:N110	6.87	No	No	0	7	9
91	R:R:L76	R:R:S287	6.01	No	No	0	7	8
92	R:R:C79	R:R:M106	6.48	No	No	0	6	5
93	R:R:L80	R:R:L83	4.15	No	Yes	0	8	6
94	R:R:L83	R:R:N86	4.12	Yes	No	0	6	5
95	R:R:L83	R:R:Y87	17.58	Yes	Yes	1	6	6
96	R:R:L83	R:R:M103	4.24	Yes	No	0	6	5
97	R:R:L83	R:R:Y284	3.52	Yes	No	1	6	7
98	R:R:N86	R:R:W91	9.04	No	Yes	0	5	4
99	R:R:N86	R:R:W93	7.91	No	Yes	0	5	9
100	R:R:W91	R:R:Y87	4.82	Yes	Yes	0	4	6
101	R:R:D92	R:R:R89	8.34	No	No	9	4	4
102	R:R:K94	R:R:R89	18.56	No	No	9	3	4
103	R:R:S178	R:R:W91	3.71	No	Yes	0	4	4
104	R:R:F277	R:R:W91	8.02	No	Yes	0	5	4
105	R:R:D92	R:R:K94	12.44	No	No	9	4	3
106	R:R:F95	R:R:W93	5.01	No	Yes	3	7	9
107	R:R:P99	R:R:W93	5.4	Yes	Yes	3	5	9
108	R:R:C100	R:R:W93	6.53	Yes	Yes	3	9	9
109	R:R:M103	R:R:W93	6.98	No	Yes	0	5	9
110	R:R:N175	R:R:W93	4.52	No	Yes	0	4	9
111	R:R:C177	R:R:W93	18.28	No	Yes	3	9	9
112	R:R:F95	R:R:P99	10.11	No	Yes	3	7	5
113	R:R:G96	R:R:P99	4.06	No	Yes	0	7	5
114	R:R:D97	R:R:R101	3.57	No	No	0	3	6
115	R:R:D97	R:R:K166	4.15	No	No	0	3	4
116	R:R:D97	R:R:P168	6.44	No	Yes	0	3	4
117	R:R:I98	R:R:P99	3.39	No	Yes	0	2	5
118	R:R:I98	R:R:R101	6.26	No	No	0	2	6
119	R:R:C100	R:R:M167	6.48	Yes	Yes	3	9	3
120	R:R:C100	R:R:P168	3.77	Yes	Yes	3	9	4
121	R:R:C100	R:R:C177	7.28	Yes	No	3	9	9
122	R:R:F105	R:R:I156	6.28	No	No	0	6	4
123	R:R:F105	R:R:T159	7.78	No	No	0	6	7
124	R:R:F105	R:R:L163	17.05	No	No	0	6	5
125	R:R:A108	R:R:T159	3.36	No	No	1	4	7
126	R:R:M109	R:R:W152	4.65	No	Yes	0	5	9
127	R:R:I156	R:R:M109	4.37	No	No	0	4	5
128	R:R:F193	R:R:R111	3.21	No	Yes	0	6	8
129	R:R:L280	R:R:R111	3.64	Yes	Yes	0	5	8
130	R:R:R111	R:R:T283	14.23	Yes	No	0	8	8
131	R:R:I116	R:R:Q112	5.49	No	Yes	0	5	7
132	R:R:Q112	R:R:T155	9.92	Yes	No	0	7	7
133	R:R:L158	R:R:Q112	11.98	No	Yes	0	5	7
134	R:R:E196	R:R:Q112	6.37	No	Yes	1	5	7
135	R:R:I115	R:R:P200	3.39	No	No	0	8	9
136	R:R:F244	R:R:I115	8.79	Yes	No	0	8	8
137	R:R:F117	R:R:W152	17.04	No	Yes	8	8	9
138	R:R:L118	R:R:N286	4.12	No	No	0	9	9
139	R:R:P200	R:R:T119	3.5	No	No	0	9	7
140	R:R:I203	R:R:T119	4.56	No	No	0	7	7
141	R:R:R125	R:R:V121	5.23	No	No	0	9	9
142	R:R:D124	R:R:R128	14.29	No	Yes	7	8	8
143	R:R:F127	R:R:Y126	5.16	Yes	Yes	2	5	7
144	R:R:V130	R:R:Y126	16.4	Yes	Yes	2	8	7
145	R:R:H131	R:R:Y126	8.71	Yes	Yes	2	7	7
146	R:R:F206	R:R:Y126	8.25	No	Yes	2	4	7
147	R:R:C207	R:R:Y126	8.06	No	Yes	0	8	7
148	R:R:R210	R:R:Y126	11.32	No	Yes	2	4	7
149	R:R:F127	R:R:H131	3.39	Yes	Yes	2	5	7
150	R:R:F127	R:R:H134	9.05	Yes	No	2	5	4
151	R:R:F127	R:R:L136	9.74	Yes	No	2	5	4
152	R:R:N137	R:R:R128	3.62	No	Yes	0	4	8
153	R:R:I211	R:R:V129	9.22	No	No	0	8	8
154	R:R:L215	R:R:V129	4.47	No	No	0	8	8
155	R:R:H131	R:R:V130	9.69	Yes	Yes	2	7	8
156	R:R:R210	R:R:V130	5.23	No	Yes	2	4	8
157	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
158	R:R:H133	R:R:P132	4.58	No	No	0	6	8
159	R:R:H134	R:R:L136	3.86	No	No	2	4	4
160	R:R:I139	R:R:T143	3.04	No	No	0	7	3
161	R:R:N141	R:R:R142	3.62	No	No	0	2	4
162	R:R:C149	R:R:L150	3.17	No	No	0	4	4
163	R:R:T155	R:R:W152	6.06	No	Yes	0	7	9
164	R:R:H161	R:R:H189	5.97	No	Yes	0	7	5
165	R:R:H189	R:R:L162	7.71	Yes	No	0	5	4
166	R:R:K165	R:R:M167	5.76	No	Yes	0	4	3
167	R:R:M167	R:R:P168	3.35	Yes	Yes	3	3	4
168	R:R:N175	R:R:P168	9.77	No	Yes	0	4	4
169	R:R:L176	R:R:N171	5.49	No	Yes	0	4	1
170	R:R:H189	R:R:S179	4.18	Yes	No	1	5	4
171	R:R:F180	R:R:F193	6.43	Yes	No	1	3	6
172	R:R:F180	R:R:R251	4.28	Yes	Yes	1	3	5
173	R:R:F180	R:R:F276	12.86	Yes	Yes	1	3	4
174	R:R:F180	R:R:L280	3.65	Yes	Yes	1	3	5
175	R:R:I182	R:R:Y269	3.63	No	No	0	3	2
176	R:R:D273	R:R:I182	4.2	No	No	0	4	3
177	R:R:H184	R:R:L258	9	Yes	No	0	3	3
178	R:R:G262	R:R:H184	6.35	No	Yes	0	4	3
179	R:R:H184	R:R:T263	5.48	Yes	No	0	3	3
180	R:R:E190	R:R:F186	7	Yes	No	1	4	4
181	R:R:A191	R:R:F186	4.16	No	No	0	3	4
182	R:R:F186	R:R:F255	6.43	No	No	1	4	5
183	R:R:H189	R:R:Q187	16.07	Yes	No	0	5	2
184	R:R:E190	R:R:H189	3.69	Yes	Yes	1	4	5
185	R:R:E190	R:R:R251	6.98	Yes	Yes	1	4	5
186	R:R:E190	R:R:F255	4.66	Yes	No	1	4	5
187	R:R:L195	R:R:M192	5.65	No	No	0	4	5
188	R:R:F193	R:R:R251	3.21	No	Yes	1	6	5
189	R:R:I252	R:R:L194	5.71	No	No	0	6	4
190	R:R:F197	R:R:F198	5.36	Yes	No	0	8	5
191	R:R:F197	R:R:F240	4.29	Yes	No	10	8	9
192	R:R:F197	R:R:F244	4.29	Yes	Yes	10	8	8
193	R:R:F197	R:R:L245	6.09	Yes	Yes	0	8	6
194	R:R:F197	R:R:V248	13.11	Yes	No	0	8	8
195	R:R:L199	R:R:P200	6.57	No	No	0	4	9
196	R:R:L201	R:R:L205	5.54	No	No	0	7	4
197	R:R:F240	R:R:L201	3.65	No	No	0	9	7
198	R:R:F206	R:R:R210	8.55	No	No	2	4	4
199	R:R:I233	R:R:S208	3.1	No	No	0	7	8
200	R:R:I211	R:R:I233	4.42	No	No	0	8	7
201	R:R:Q217	R:R:W213	5.48	No	No	0	5	3
202	R:R:I226	R:R:L215	5.71	No	No	0	6	8
203	R:R:D221	R:R:R216	5.96	No	No	0	3	4
204	R:R:M220	R:R:R218	4.96	No	No	0	3	5
205	R:R:Q219	R:R:R222	3.5	No	No	0	3	3
206	R:R:D221	R:R:R222	10.72	No	No	0	3	3
207	R:R:R228	R:R:S297	11.86	No	No	0	7	6
208	R:R:F232	R:R:V292	3.93	Yes	No	0	7	6
209	R:R:F232	R:R:F296	4.29	Yes	No	0	7	8
210	R:R:F232	R:R:S297	18.5	Yes	No	0	7	6
211	R:R:F240	R:R:F244	10.72	No	Yes	10	9	8
212	R:R:C243	R:R:I242	3.27	No	No	0	8	5
213	R:R:F282	R:R:I242	11.3	No	No	0	7	5
214	R:R:C243	R:R:N286	6.3	No	No	0	8	9
215	R:R:F244	R:R:T283	5.19	Yes	No	0	8	8
216	R:R:F244	R:R:N286	9.67	Yes	No	0	8	9
217	R:R:L245	R:R:P246	3.28	Yes	No	0	6	9
218	R:R:P246	R:R:T279	3.5	No	No	0	9	7
219	R:R:F282	R:R:P246	4.33	No	No	0	7	9
220	R:R:S247	R:R:T279	3.2	No	No	0	6	7
221	R:R:L280	R:R:S247	4.5	Yes	No	0	5	6
222	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
223	R:R:I254	R:R:R251	3.76	No	Yes	0	4	5
224	R:R:F276	R:R:R251	10.69	Yes	Yes	1	4	5
225	R:R:I252	R:R:W256	7.05	No	No	0	6	4
226	R:R:R253	R:R:V272	3.92	No	No	0	5	4
227	R:R:I254	R:R:V272	6.14	No	No	0	4	4
228	R:R:L257	R:R:Y269	5.86	No	No	0	3	2
229	R:R:C266	R:R:T263	3.38	No	No	0	7	3
230	R:R:E267	R:R:N265	18.4	No	No	0	2	5
231	R:R:E267	R:R:V268	9.98	No	No	0	2	1
232	R:R:V268	R:R:Y269	3.79	No	No	0	1	2
233	R:R:D273	R:R:F277	8.36	No	No	0	4	5
234	R:R:F276	R:R:L280	7.31	Yes	Yes	1	4	5
235	R:R:F282	R:R:M285	9.95	No	No	0	7	5
236	R:R:T283	R:R:Y284	4.99	No	No	0	8	7
237	R:R:L289	R:R:M285	8.48	No	No	0	7	5
238	R:R:L289	R:R:M288	4.24	No	No	0	7	8
239	R:R:D290	R:R:Y294	17.24	Yes	Yes	4	9	9
240	R:R:P291	R:R:Y295	12.52	No	Yes	0	9	7
241	R:R:P299	R:R:S298	3.56	No	No	0	5	8
242	R:R:S298	R:R:S300	3.26	No	No	0	8	5
243	R:R:L66	R:R:V293	2.98	No	No	0	8	8
244	R:R:L75	R:R:V71	2.98	No	No	0	6	6
245	R:R:L163	R:R:V160	2.98	No	No	0	5	4
246	R:R:L194	R:R:V248	2.98	No	No	0	4	8
247	R:R:L289	R:R:V239	2.98	No	No	0	7	7
248	R:R:L245	R:R:V241	2.98	Yes	No	0	6	5
249	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
250	R:R:I146	R:R:I147	2.94	No	No	0	3	5
251	R:R:I212	R:R:I230	2.94	No	No	0	5	6
252	R:R:I226	R:R:M220	2.92	No	No	0	6	3
253	R:R:E37	R:R:V33	2.85	No	No	0	7	5
254	R:R:I116	R:R:L151	2.85	No	No	0	5	7
255	R:R:I139	R:R:L136	2.85	No	No	0	7	4
256	R:R:I154	R:R:L151	2.85	No	No	0	5	7
257	R:R:I154	R:R:L158	2.85	No	No	0	5	5
258	R:R:I230	R:R:L215	2.85	No	No	0	6	8
259	R:R:L102	R:R:M106	2.83	No	No	0	5	5
260	R:R:L104	R:R:M167	2.83	No	Yes	0	5	3
261	R:R:M106	R:R:N110	2.8	No	No	0	5	9
262	R:R:C266	R:R:F21	2.79	No	Yes	0	7	2
263	R:R:A174	R:R:R22	2.77	No	No	0	2	3
264	R:R:L43	R:R:L47	2.77	No	No	0	4	6
265	R:R:H223	R:R:I226	2.65	No	No	0	4	6
266	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
267	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
268	R:R:F232	R:R:T231	2.59	Yes	No	0	7	6
269	R:R:F40	R:R:I39	2.51	No	No	0	6	5
270	R:R:F65	R:R:I147	2.51	No	No	0	7	5
271	R:R:F82	R:R:M103	2.49	No	No	0	6	5
272	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
273	R:R:L47	R:R:Y295	2.34	No	Yes	0	6	7
274	R:R:Q217	R:R:R218	2.34	No	No	0	5	5
275	R:R:M192	R:R:W188	2.33	No	No	0	5	5
276	R:R:D85	R:R:W93	2.23	No	Yes	0	4	9
277	R:R:G172	R:R:G173	2.11	No	No	0	3	4
278	R:R:F296	R:R:Y295	2.06	No	Yes	0	8	7
279	R:R:R63	R:R:W59	2	No	No	0	7	6
280	R:R:A72	R:R:G113	1.95	No	No	0	8	7
281	R:R:G157	R:R:V160	1.84	No	No	0	5	4
282	R:R:A122	R:R:C207	1.81	No	No	0	9	8
283	R:R:G41	R:R:I77	1.76	No	No	0	8	6
284	R:R:G153	R:R:I156	1.76	No	No	0	4	4
285	R:R:G35	R:R:M84	1.75	No	No	0	5	7
286	R:R:C18	R:R:S181	1.72	No	No	0	9	4
287	R:R:A144	R:R:S61	1.71	No	No	0	7	6
288	R:R:G202	R:R:L201	1.71	No	No	0	3	7
289	R:R:A237	R:R:S208	1.71	No	No	0	7	8
290	R:R:G172	R:R:N171	1.7	No	Yes	0	3	1
291	R:R:A275	R:R:V250	1.7	No	No	0	5	5
292	R:R:M84	R:R:P31	1.68	No	No	0	7	6
293	R:R:L80	R:R:P81	1.64	No	No	0	8	8
294	R:R:C149	R:R:I146	1.64	No	No	0	4	3
295	R:R:G172	R:R:Q170	1.64	No	No	0	3	1
296	R:R:A145	R:R:I64	1.62	No	Yes	0	3	7
297	R:R:A122	R:R:I204	1.62	No	No	0	9	8
298	R:R:A237	R:R:I204	1.62	No	No	0	7	8
299	R:R:V120	R:R:V121	1.6	No	No	0	7	9
300	R:R:V235	R:R:V292	1.6	No	No	0	5	6
301	R:R:V236	R:R:V293	1.6	No	No	0	8	8
302	R:R:S261	R:R:T260	1.6	No	No	0	3	1
303	R:R:C53	R:R:L49	1.59	No	No	0	4	7
304	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
305	R:R:K164	R:R:V160	1.52	No	No	0	4	4
306	R:R:A135	R:R:H134	1.46	No	No	0	5	4
307	R:R:I238	R:R:M234	1.46	No	No	0	5	4
308	R:R:A145	R:R:R142	1.38	No	No	0	3	4
309	R:R:D92	R:R:N175	1.35	No	No	0	4	4
310	R:R:R63	R:R:S300	1.32	No	No	0	7	5
311	R:R:R89	R:R:V88	1.31	No	No	0	4	3
312	R:R:L49	R:R:W50	1.14	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.23833	12	1	0
2	R:R:K16	6.17	4	0	4
3	R:R:F21	7.455	4	0	2
4	R:R:F25	4.9625	4	6	6
5	R:R:L30	7.05	4	1	5
6	R:R:N45	6.9375	4	4	9
7	R:R:I64	5.115	4	0	7
8	R:R:F67	7.6225	4	0	6
9	R:R:D73	7.2875	4	4	9
10	R:R:L83	6.64667	6	1	6
11	R:R:Y87	7.792	5	1	6
12	R:R:W91	6.3975	4	0	4
13	R:R:W93	7.1075	8	3	9
14	R:R:P99	5.74	4	3	5
15	R:R:C100	6.015	4	3	9
16	R:R:R111	7.4325	4	0	8
17	R:R:Q112	8.132	5	1	7
18	R:R:Y126	8.61714	7	2	7
19	R:R:F127	5.992	5	2	5
20	R:R:R128	7.4425	4	7	8
21	R:R:V130	9.0425	4	2	8
22	R:R:H131	5.83	4	2	7
23	R:R:W152	7.876	5	8	9
24	R:R:M167	4.605	4	3	3
25	R:R:P168	5.8325	4	3	4
26	R:R:N171	4.375	4	0	1
27	R:R:F180	9.704	5	1	3
28	R:R:H184	6.5175	4	0	3
29	R:R:H189	8.62833	6	1	5
30	R:R:E190	5.5825	4	1	4
31	R:R:F197	6.628	5	10	8
32	R:R:F232	7.3275	4	0	7
33	R:R:F244	7.732	5	10	8
34	R:R:L245	3.8325	4	0	6
35	R:R:R251	5.784	5	1	5
36	R:R:F276	8.6975	4	1	4
37	R:R:L280	4.775	4	1	5
38	R:R:D290	12.0325	4	4	9
39	R:R:Y294	8.256	5	4	9
40	R:R:Y295	5.054	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	98.6889	6.27	Yes	Yes	1	0	6
2	R:R:L83	R:R:N86	58.0067	4.12	Yes	No	0	6	5
3	R:R:N86	R:R:W91	41.6819	9.04	No	Yes	0	5	4
4	R:R:F277	R:R:W91	76.1476	8.02	No	Yes	0	5	4
5	R:R:D273	R:R:F277	74.7155	8.36	No	No	0	4	5
6	R:R:D273	R:R:F21	63.2061	4.78	No	Yes	0	4	2
7	R:R:F21	R:R:H9	19.4382	15.84	Yes	No	0	2	6
8	R:R:L83	R:R:Y87	47.0336	17.58	Yes	Yes	1	6	6
9	R:R:W91	R:R:Y87	39.2431	4.82	Yes	Yes	0	4	6
10	R:R:H9	R:R:R22	17.5252	16.93	No	No	0	6	3
11	R:R:C266	R:R:F21	28.8996	2.79	No	Yes	0	7	2
12	R:R:C266	R:R:T263	25.1358	3.38	No	No	0	7	3
13	R:R:H184	R:R:T263	23.2435	5.48	Yes	No	0	3	3
14	R:R:H184	R:R:K16	17.5252	5.24	Yes	Yes	0	3	4
15	R:R:N171	R:R:R22	13.6783	4.82	Yes	No	0	1	3
16	L:L:?1	R:R:H189	11.6719	14.15	Yes	Yes	1	0	5
17	R:R:F21	R:R:R270	15.6052	6.41	Yes	No	0	2	1
18	R:R:D23	R:R:R270	13.6783	7.15	No	No	0	4	1
19	L:L:?1	R:R:R111	30.1138	8.65	Yes	Yes	0	0	8
20	R:R:L280	R:R:R111	16.8091	3.64	Yes	Yes	0	5	8
21	R:R:L280	R:R:S247	32.1133	4.5	Yes	No	0	5	6
22	R:R:S247	R:R:T279	30.0412	3.2	No	No	0	6	7
23	R:R:P246	R:R:T279	28.0382	3.5	No	No	0	9	7
24	R:R:F282	R:R:P246	33.0647	4.33	No	No	0	7	9
25	R:R:F282	R:R:M285	36.6416	9.95	No	No	0	7	5
26	R:R:E37	R:R:M285	16.6845	8.12	No	No	0	7	5
27	L:L:?1	R:R:F180	25.1289	21.3	Yes	Yes	1	0	3
28	R:R:F180	R:R:L280	17.0201	3.65	Yes	Yes	1	3	5
29	R:R:E37	R:R:M288	10.0356	9.47	No	No	0	7	8
30	R:R:L289	R:R:M285	16.6845	8.48	No	No	0	7	5
31	R:R:L289	R:R:M288	10.0356	4.24	No	No	0	7	8
32	R:R:L80	R:R:L83	11.8899	4.15	No	Yes	0	8	6
33	R:R:L80	R:R:P81	10.596	1.64	No	No	0	8	8
34	R:R:F40	R:R:M288	13.3705	7.46	No	No	0	6	8
35	L:L:?1	R:R:L107	100	7.17	Yes	No	0	0	6
36	R:R:L107	R:R:L76	99.3531	4.15	No	No	0	6	7
37	R:R:L76	R:R:S287	35.3651	6.01	No	No	0	7	8
38	R:R:D73	R:R:S287	34.2132	7.36	Yes	No	0	9	8
39	R:R:D73	R:R:N45	23.3888	5.39	Yes	Yes	4	9	9
40	R:R:N45	R:R:P291	16.5323	3.26	Yes	No	0	9	9
41	R:R:P291	R:R:Y295	15.2662	12.52	No	Yes	0	9	7
42	R:R:L76	R:R:N110	77.009	6.87	No	No	0	7	9
43	R:R:L75	R:R:N110	73.522	8.24	No	No	0	6	9
44	R:R:L75	R:R:V71	72.6329	2.98	No	No	0	6	6
45	R:R:F67	R:R:V71	71.7369	7.87	Yes	No	0	6	6
46	R:R:F67	R:R:W59	66.2988	11.02	Yes	No	0	6	6
47	R:R:I64	R:R:W59	60.6531	10.57	Yes	No	0	7	6
48	R:R:A144	R:R:I64	48.6526	3.25	No	Yes	0	7	7
49	R:R:A144	R:R:S61	47.5836	1.71	No	No	0	7	6
50	R:R:I139	R:R:S61	42.2216	6.19	No	No	0	7	6
51	R:R:F65	R:R:I64	10.219	5.02	No	Yes	0	7	7
52	L:L:?1	R:R:Q112	16.5323	6.9	Yes	Yes	1	0	7
53	R:R:Q112	R:R:T155	10.3919	9.92	Yes	No	0	7	7
54	R:R:N86	R:R:W93	24.8763	7.91	No	Yes	0	5	9
55	R:R:N175	R:R:W93	15.8093	4.52	No	Yes	0	4	9
56	R:R:L83	R:R:M103	22.396	4.24	Yes	No	0	6	5
57	R:R:M103	R:R:W93	20.559	6.98	No	Yes	0	5	9
58	R:R:C100	R:R:W93	13.8167	6.53	Yes	Yes	3	9	9
59	L:L:?1	R:R:T159	11.5993	6.68	Yes	No	1	0	7
60	R:R:F105	R:R:T159	10.3643	7.78	No	No	0	6	7
61	R:R:R111	R:R:T283	13.0833	14.23	Yes	No	0	8	8
62	L:L:?1	R:R:Y284	12.3188	5.31	Yes	No	1	0	7
63	R:R:T283	R:R:Y284	38.572	4.99	No	No	0	8	7
64	R:R:F244	R:R:T283	50.1989	5.19	Yes	No	0	8	8
65	R:R:F244	R:R:N286	13.4431	9.67	Yes	No	0	8	9
66	R:R:I139	R:R:L136	39.9972	2.85	No	No	0	7	4
67	R:R:F127	R:R:L136	36.396	9.74	Yes	No	2	5	4
68	R:R:F127	R:R:Y126	28.1593	5.16	Yes	Yes	2	5	7
69	R:R:I211	R:R:Y126	17.6186	2.42	No	Yes	0	8	7
70	R:R:I211	R:R:V129	12.8308	9.22	No	No	0	8	8
71	R:R:L215	R:R:V129	11.5543	4.47	No	No	0	8	8
72	R:R:D273	R:R:I182	11.4713	4.2	No	No	0	4	3
73	R:R:F197	R:R:F244	21.9601	4.29	Yes	Yes	10	8	8
74	R:R:F197	R:R:L245	12.8689	6.09	Yes	Yes	0	8	6
75	R:R:C243	R:R:N286	10.2259	6.3	No	No	0	8	9
76	R:R:L83	R:R:Y284	27.1076	3.52	Yes	No	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	6.27	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	7.17	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	7.14	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.65	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q112	6.9	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T159	6.68	1	Yes	No	0	7	0	1
L:L:?1	R:R:S179	9.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	21.3	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	14.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	6.41	1	Yes	No	0	5	0	1
L:L:?1	R:R:E196	11.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	5.31	1	Yes	No	0	7	0	1
R:R:L107	R:R:L76	4.15	0	No	No	6	7	1	2
R:R:L80	R:R:L83	4.15	0	No	Yes	8	6	2	1
R:R:L83	R:R:N86	4.12	1	Yes	No	6	5	1	2
R:R:L83	R:R:Y87	17.58	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	4.24	1	Yes	No	6	5	1	2
R:R:L83	R:R:Y284	3.52	1	Yes	No	6	7	1	1
R:R:F105	R:R:T159	7.78	0	No	No	6	7	2	1
R:R:A108	R:R:T159	3.36	1	No	No	4	7	1	1
R:R:F193	R:R:R111	3.21	1	No	Yes	6	8	2	1
R:R:L280	R:R:R111	3.64	1	Yes	Yes	5	8	2	1
R:R:R111	R:R:T283	14.23	0	Yes	No	8	8	1	2
R:R:I116	R:R:Q112	5.49	0	No	Yes	5	7	2	1
R:R:Q112	R:R:T155	9.92	1	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	11.98	0	No	Yes	5	7	2	1
R:R:E196	R:R:Q112	6.37	1	No	Yes	5	7	1	1
R:R:H161	R:R:H189	5.97	0	No	Yes	7	5	2	1
R:R:H189	R:R:L162	7.71	1	Yes	No	5	4	1	2
R:R:H189	R:R:S179	4.18	1	Yes	No	5	4	1	1
R:R:F180	R:R:F193	6.43	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	12.86	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	Yes	3	5	1	2
R:R:H189	R:R:Q187	16.07	1	Yes	No	5	2	1	2
R:R:E190	R:R:H189	3.69	1	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	6.98	1	Yes	Yes	4	5	2	2
R:R:L195	R:R:M192	5.65	0	No	No	4	5	2	1
R:R:F193	R:R:R251	3.21	1	No	Yes	6	5	2	2
R:R:F276	R:R:R251	10.69	1	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	7.31	1	Yes	Yes	4	5	2	2
R:R:T283	R:R:Y284	4.99	0	No	No	8	7	2	1
R:R:M192	R:R:W188	2.33	0	No	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IYH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	275
Number of Links	312
Number of Hubs	40
Number of Links mediated by Hubs	155
Number of Communities	10
Number of Nodes involved in Communities	59
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	65211
Length Of Smallest Path	3
Average Path Length	14.616
Length of Longest Path	37
Minimum Path Strength	1.365
Average Path Strength	6.55237
Maximum Path Strength	17.1733
Minimum Path Correlation	0.7
Average Path Correlation	0.930274
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	50.4641
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6171
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • nicotinic acid receptor activity • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • myeloid cell apoptotic process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • positive regulation of biological process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • positive regulation of cellular process • positive regulation of protein secretion • endocrine process • positive regulation of transport • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FI7
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IYH_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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