Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F10 5.5875407
2R:R:F21 5.52692
3R:R:E37 4.50254217
4R:R:N45 4.0175409
5R:R:F65 4.575407
6R:R:L76 8.03407
7R:R:R90 6.0925404
8R:R:W91 7.532504
9R:R:D92 6.5175404
10R:R:W93 6.27833609
11R:R:L104 5.3454115
12R:R:M109 4.7375405
13R:R:Q112 5.86754227
14R:R:Y126 5.373336127
15R:R:F127 4.1545125
16R:R:R128 6.4645278
17R:R:V130 6.6154128
18R:R:H131 5.51754127
19R:R:H133 6.775406
20R:R:H134 4.884124
21R:R:W152 5.1345259
22R:R:M167 3.29754113
23R:R:P168 4.72254114
24R:R:L176 3.4375404
25R:R:C183 5.18754201
26R:R:M192 3.44754225
27R:R:E196 8.15754225
28R:R:F197 5.9845188
29R:R:L201 5.2825407
30R:R:R210 3.8454124
31R:R:L215 2.8775408
32R:R:R218 5.8675455
33R:R:M220 4.79453
34R:R:F244 5.021437188
35R:R:R251 6.496676105
36R:R:F255 8.294105
37R:R:Y269 4.14333692
38R:R:F276 5.4954104
39R:R:I278 2.5406
40R:R:T279 4.34754107
41R:R:M288 6.00754218
42R:R:Y294 5.683336179
43R:R:Y295 7.6625177
44B:B:R8 3.89754283
45B:B:A11 2.26405
46B:B:I18 3.09754297
47B:B:M45 4.2575404
48B:B:R48 3.9925427
49B:B:L51 5.784529
50B:B:H54 9.26833629
51B:B:Y59 5.778518
52B:B:W63 6.576507
53B:B:L70 5.805425
54B:B:D76 4.94429
55B:B:W82 8.795629
56B:B:Y85 9.7625424
57B:B:N88 5.0954327
58B:B:K89 6.46714729
59B:B:H91 5.33754155
60B:B:I93 4.305407
61B:B:L95 4.2345238
62B:B:W99 6.26429719
63B:B:Y105 3.786156
64B:B:N110 6.5375434
65B:B:Y111 5.416534
66B:B:C114 4.12254238
67B:B:N119 3.8775409
68B:B:I123 3.322536
69B:B:Y124 5.432506
70B:B:L126 3.81254155
71B:B:H142 5.66143739
72B:B:Y145 4.24508
73B:B:L146 3.8875437
74B:B:F151 3.12333639
75B:B:L152 3.5325403
76B:B:I157 2.9775437
77B:B:T159 5.34439
78B:B:S160 4.04406
79B:B:S161 6.6375439
80B:B:D163 6.91539
81B:B:T165 5.9437
82B:B:W169 7.70667638
83B:B:I171 3.4625436
84B:B:F180 5.876567
85B:B:H183 6.604569
86B:B:D186 5.6325489
87B:B:L190 3.5725465
88B:B:F199 6.098569
89B:B:V200 4.304546
90B:B:C204 5.932587
91B:B:K209 10.1725466
92B:B:L210 4.5125405
93B:B:W211 7.54833668
94B:B:D212 7.24249
95B:B:E215 7.88754243
96B:B:Q220 8.3175447
97B:B:H225 9.09667649
98B:B:I232 5.0975448
99B:B:F234 5.0825445
100B:B:F235 4.998336196
101B:B:P236 5.66754197
102B:B:F241 5.02333646
103B:B:T243 5.268548
104B:B:D247 7.225449
105B:B:T249 4.985446
106B:B:R251 10.296548
107B:B:F253 7.73446
108B:B:D258 10.1125447
109B:B:Y264 4.30667605
110B:B:I269 2.922504
111B:B:F278 5.7454197
112B:B:R283 5.8685309
113B:B:Y289 6.226137
114B:B:D290 8.4275416
115B:B:N295 6.5165136
116B:B:W297 5.5385138
117B:B:L300 3.944306
118B:B:R304 5.96754135
119B:B:H311 7.8565169
120B:B:R314 10.065418
121B:B:L318 3.254506
122B:B:W332 9.65429719
123B:B:D333 6.2854169
124B:B:K337 7.474166
125B:B:W339 7.665169
126B:B:N340 6.06429
127A:A:E33 8.785406
128A:A:V34 6.28455
129A:A:L37 4.3225419
130A:A:L38 4.2154148
131A:A:K46 5.644149
132A:A:E186 5.9275419
133A:A:F191 8.1425455
134A:A:L194 6.0725454
135A:A:F196 9.4625457
136A:A:F199 8.5625415
137A:A:Q204 3.475419
138A:A:E207 9.565489
139A:A:K210 6.26571789
140A:A:W211 4.104519
141A:A:H213 6.065418
142A:A:F215 3.84667619
143A:A:I221 4.3825418
144A:A:I222 3.89254147
145A:A:V225 3.28407
146A:A:Y230 6.89254338
147A:A:R242 6.015409
148A:A:M243 4.8975478
149A:A:F250 5.53579
150A:A:C254 3.712575
151A:A:W258 5.35167615
152A:A:F259 5.98419
153A:A:F267 3.896149
154A:A:L268 5.9925408
155A:A:F274 4.72409
156A:A:Y287 5.8554347
157A:A:Y296 6.3875404
158A:A:Y302 6.294346
159A:A:I303 2.7825477
160A:A:F307 3.888578
161A:A:Y320 5.1175407
162A:A:T321 6.646575
163A:A:H322 6.1825409
164A:A:F336 5.1875458
165A:A:T340 5.045456
166A:A:I344 4.115456
167A:A:L353 5.785407
168A:A:F354 6.05605
169G:G:R27 4.6275408
170G:G:Y40 6.5354196
171G:G:D48 6.112509
172G:G:L51 3.498506
173G:G:N59 5.2775429
174G:G:P60 5.9975429
175G:G:F61 4.925828
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L83 R:R:Y87 10.39765.86NoNo066
2R:R:L80 R:R:L83 18.33614.15NoNo086
3R:R:L76 R:R:L80 19.9735.54YesNo078
4R:R:F193 R:R:R251 12.48057.48NoYes065
5R:R:F193 R:R:R111 12.747512.83NoNo068
6R:R:F244 R:R:R111 25.3717.48YesNo088
7R:R:F244 R:R:N286 45.73168.46YesNo1889
8R:R:D290 R:R:N286 46.273312.12NoNo099
9R:R:D290 R:R:D73 27.61613.99NoNo099
10R:R:L76 R:R:S287 24.06486.01YesNo078
11R:R:D73 R:R:S287 24.33765.89NoNo098
12R:R:L69 R:R:Y295 74.05823.52NoYes097
13R:R:D290 R:R:L69 73.53854.07NoNo099
14R:R:E196 R:R:R111 12.77510.47YesNo058
15R:R:E196 R:R:Q112 22.027414.02YesYes2257
16R:R:I116 R:R:Q112 19.83432.74NoYes057
17R:R:I116 R:R:L151 19.28475.71NoNo057
18R:R:F117 R:R:L151 12.12386.09NoNo087
19R:R:Y294 R:R:Y295 75.99282.98YesYes1797
20R:R:F117 R:R:W152 10.4718.02NoYes2589
21R:R:E196 R:R:I115 12.58512.73YesNo058
22R:R:F244 R:R:I115 14.22265.02YesNo088
23R:R:R125 R:R:Y294 80.774210.29NoYes1799
24A:A:L353 R:R:R125 81.30118.5YesNo079
25A:A:L348 A:A:L353 82.33092.77NoYes097
26A:A:L348 R:R:V129 87.22542.98NoNo098
27R:R:I211 R:R:V129 96.56629.22NoNo088
28R:R:I211 R:R:Y126 96.79862.42NoYes087
29R:R:F127 R:R:Y126 49.10583.09YesYes1257
30R:R:H131 R:R:Y126 49.05963.27YesYes1277
31R:R:F127 R:R:H134 49.29845.66YesYes1254
32R:R:H131 R:R:H134 49.94675.97YesYes1274
33R:R:L215 R:R:V129 16.33142.98YesNo088
34R:R:L215 R:R:M220 13.4852.83YesYes083
35A:A:E28 R:R:K138 99.67776.75NoNo044
36R:R:A135 R:R:K138 99.57281.61NoNo054
37R:R:A135 R:R:H134 99.47231.46NoYes054
38B:B:H183 B:B:K209 29.932411.79YesYes696
39B:B:H183 B:B:S207 56.04882.79YesNo095
40B:B:D205 B:B:S207 56.287.36NoNo095
41B:B:D205 B:B:G185 56.74221.68NoNo095
42B:B:D186 B:B:G185 57.20631.68YesNo095
43B:B:D186 B:B:Y145 58.28093.45YesYes098
44A:A:S206 B:B:Y145 73.61263.82NoYes088
45A:A:Q204 A:A:S206 29.59072.89YesNo198
46A:A:Q204 B:B:L117 30.05093.99YesNo099
47B:B:L117 B:B:W99 30.1515.69NoYes099
48A:A:E186 B:B:W99 30.22225.45YesYes199
49A:A:E186 A:A:K197 40.09772.7YesNo196
50A:A:E33 A:A:K197 70.238117.55YesNo066
51A:A:E33 A:A:K29 1001.35YesNo061
52A:A:E28 A:A:K29 99.89141.35NoNo041
53A:A:S206 A:A:W211 44.25083.71NoYes189
54A:A:F215 A:A:W211 41.61944.01YesYes199
55A:A:F215 B:B:W99 31.40984.01YesYes199
56A:A:F199 B:B:W99 60.40059.02YesYes159
57A:A:F199 A:A:K197 30.21114.96YesNo156
58A:A:F199 A:A:K35 30.21127.44YesNo059
59A:A:E33 A:A:K35 30.20212.7YesNo069
60B:B:L210 B:B:Q220 11.2363.99YesYes057
61B:B:L198 B:B:L210 28.31495.54NoYes035
62B:B:D212 B:B:L198 30.25962.71YesNo093
63B:B:D212 B:B:E215 32.687312.99YesYes2493
64B:B:E215 B:B:G216 34.63063.27YesNo034
65B:B:F180 B:B:G216 35.11563.01YesNo074
66B:B:F180 B:B:W211 40.741511.02YesYes678
67B:B:S201 B:B:W211 22.69677.41NoYes698
68B:B:H183 B:B:S201 22.92795.58YesNo699
69B:B:K209 B:B:W211 22.83715.8YesYes668
70B:B:C271 B:B:D290 10.52949.34NoYes056
71B:B:D290 B:B:R314 10.666116.68YesYes168
72B:B:R314 B:B:W332 12.766117.99YesYes189
73B:B:W332 B:B:Y59 29.80496.75YesYes198
74B:B:Q75 B:B:Y59 30.50127.89NoYes198
75B:B:Q75 B:B:W99 31.11546.57NoYes199
76B:B:L70 B:B:M61 10.46885.65YesNo056
77B:B:C317 B:B:M61 13.64196.48NoNo076
78B:B:C317 B:B:S316 13.9133.44NoNo079
79B:B:S316 B:B:W332 14.04984.94NoYes099
80B:B:H142 B:B:S161 11.05713.95YesYes399
81B:B:G162 B:B:S161 13.56793.71NoYes099
82B:B:G162 B:B:Y145 13.81714.35NoYes098
83B:B:L210 B:B:V200 16.11742.98YesYes056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IJ3
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic acid
SubType HCA2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.28
Date 2024-01-03
D.O.I. 10.1038/s41421-023-00610-7
Net Summary
Imin 2.51
Number of Linked Nodes 851
Number of Links 1053
Number of Hubs 175
Number of Links mediated by Hubs 638
Number of Communities 34
Number of Nodes involved in Communities 248
Number of Links involved in Communities 345
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 3165038
Length Of Smallest Path 3
Average Path Length 36.3354
Length of Longest Path 59
Minimum Path Strength 1.115
Average Path Strength 5.30034
Maximum Path Strength 20.6
Minimum Path Correlation 0.71
Average Path Correlation 0.991103
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 38.4797
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.5575
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDS4
Sequence
>8IJ3_Chain_R
DHFLEIDKK NCCVFRDDF IVKVLPPVL GLEFIFGLL GNGLALWIF 
CFHLKSWKS SRIFLFNLA VADFLLIIC LPFLMDNYV RRWDWKFGD 
IPCRLMLFM LAMNRQGSI IFLTVVAVD RYFRVVHPH HALNKISNR 
TAAIISCLL WGITIGLTV HLLKKKMPI QNGGANLCS SFSICHTFQ 
WHEAMFLLE FFLPLGIIL FCSARIIWS LRQRQMDRH AKIKRAITF 
IMVVAIVFV ICFLPSVVV RIRIFWLLH TSGTQNCEV YRSVDLAFF 
ITLSFTYMN SMLDPVVYY FSSP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IJ3_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8IJ3_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IJ3_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK2AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.12023-02-2210.1038/s41467-023-37177-6
7ZL9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
7ZLYAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens---2.72023-04-1210.1038/s41467-023-37177-6
8H2GAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.012023-10-11To be published
8I7VAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;22.772024-02-0710.1038/s41467-023-42764-8
8I7WAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;23.392024-02-0710.1038/s41467-023-42764-8
8IHBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.852023-09-1310.1038/s41467-023-41650-7
8IHFAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.972023-08-3010.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensLUF6283-Gi1/&β;1/&γ;23.062023-08-3010.1038/s41467-023-41650-7
8IHIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcifran-Gi1/&β;1/&γ;23.112023-08-3010.1038/s41467-023-41650-7
8IJAAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;22.692024-01-0310.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Gi1/&β;1/&γ;23.232024-01-0310.1038/s41421-023-00610-7
8IJDAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;23.252024-01-0310.1038/s41421-023-00610-7
8IY9AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Go/&β;1/&γ;23.372024-03-0610.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Go/&β;1/&γ;23.32024-03-0610.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8J6IAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.922024-04-0310.1016/j.celrep.2023.113406
8J6JAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073-Gi1/&β;1/&γ;22.82024-01-1010.1016/j.celrep.2023.113406
8J6LAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.052024-04-0310.1016/j.celrep.2023.113406
8J6PAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;22.552023-12-0610.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensBeta-hydroxybutyrateCompound 9nGi1/&β;1/&γ;22.62023-12-0610.1038/s41467-023-43537-z
8J6RAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.762023-12-0610.1038/s41467-023-43537-z
8JERAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox-Go/&β;1/&γ;23.452024-03-0610.1038/s41467-024-46239-2
8JHNAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Go/&β;1/&γ;23.752024-03-0610.1038/s41467-024-46239-2
8JHYAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiens-Compound 9nGi1/&β;1/&γ;22.872023-09-0610.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacinCompound 9nGi1/&β;1/&γ;23.172023-09-0610.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/&β;1/&γ;23.52023-09-0610.1016/j.molcel.2023.07.030
8JIMAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMMF-Gi1/&β;1/&γ;22.982023-09-0610.1016/j.molcel.2023.07.030
8JZ7AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensMK6892-Gi1/&β;1/&γ;22.62023-10-0410.1038/s41392-023-01625-y
8K5BAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin--3.432023-11-2210.1038/s41467-023-42764-8
8K5CAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensAcipimox--3.132023-11-2210.1038/s41467-023-42764-8
8K5DAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensGSK256073--3.742023-11-2210.1038/s41467-023-42764-8




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