Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 6.28465
2A:A:L37 4.32254129
3A:A:K46 5.64409
4A:A:F191 8.1425465
5A:A:L194 6.0725464
6A:A:F196 9.4625467
7A:A:F199 8.5625425
8A:A:Q204 3.4754249
9A:A:K210 5.49429779
10A:A:W211 4.1045249
11A:A:H213 6.065428
12A:A:I221 4.38254128
13A:A:V225 3.28407
14A:A:Y230 6.89254258
15A:A:R242 7.50254239
16A:A:F250 6.285409
17A:A:C254 3.712505
18A:A:W258 5.35167625
19A:A:F259 5.984129
20A:A:L268 5.9925408
21A:A:F274 4.72409
22A:A:Y287 5.8554267
23A:A:Y302 7.13254266
24A:A:F307 4.2325408
25A:A:Y320 5.1175407
26A:A:T321 6.6465175
27A:A:H322 6.1825409
28A:A:F336 5.1875468
29A:A:T340 5.045406
30A:A:L353 5.785407
31A:A:F354 6.05605
32B:B:R8 3.89754293
33B:B:A11 2.26405
34B:B:I18 3.09754307
35B:B:M45 4.2575404
36B:B:R48 3.9925437
37B:B:L51 5.784549
38B:B:H54 9.26833649
39B:B:Y59 5.778528
40B:B:W63 6.576507
41B:B:L70 5.805445
42B:B:D76 4.94449
43B:B:W82 8.795649
44B:B:K89 6.46714749
45B:B:H91 5.33754345
46B:B:I93 4.305407
47B:B:L95 4.2345188
48B:B:W99 6.26429729
49B:B:Y105 4.032506
50B:B:N110 6.5375414
51B:B:Y111 5.416514
52B:B:C114 4.12254188
53B:B:N119 3.8775409
54B:B:I123 3.322516
55B:B:Y124 5.432506
56B:B:L126 3.8125405
57B:B:H142 6.14833619
58B:B:Y145 4.24508
59B:B:L146 3.8875417
60B:B:F151 3.12333619
61B:B:L152 3.5325403
62B:B:I157 2.9775417
63B:B:T159 5.34419
64B:B:S160 4.04406
65B:B:S161 6.6375419
66B:B:D163 7.745419
67B:B:W169 7.70667618
68B:B:F180 5.876587
69B:B:H183 6.604589
70B:B:L190 3.5725405
71B:B:F199 6.9675489
72B:B:V200 4.7254356
73B:B:C204 5.135477
74B:B:K209 10.1725486
75B:B:L210 4.5125405
76B:B:W211 7.54833688
77B:B:E215 7.88754193
78B:B:Q220 8.31754317
79B:B:H225 10.368559
80B:B:I232 5.0975408
81B:B:F234 5.08254355
82B:B:F235 4.998336136
83B:B:P236 5.66754137
84B:B:F241 6.2325406
85B:B:T243 5.9375458
86B:B:D247 7.225459
87B:B:R251 10.296558
88B:B:F253 7.73456
89B:B:D258 10.11254317
90B:B:Y264 4.30667605
91B:B:I269 3.025404
92B:B:F278 5.7454137
93B:B:R283 5.8685329
94B:B:Y289 6.226107
95B:B:D290 8.4275406
96B:B:N295 6.5165106
97B:B:W297 6.2754108
98B:B:L300 3.944326
99B:B:H311 7.8565119
100B:B:L318 3.254506
101B:B:W332 9.65429729
102B:B:D333 6.2854119
103B:B:K337 7.474116
104B:B:W339 7.665119
105B:B:N340 6.06439
106G:G:Y40 6.5354136
107G:G:D48 6.112509
108G:G:L51 3.498506
109G:G:N59 5.2775439
110G:G:P60 5.9975439
111G:G:F61 5.27738
112R:R:F21 6.1225362
113R:R:L30 4.1325375
114R:R:E37 4.50254217
115R:R:N45 4.0175409
116R:R:L76 8.03407
117R:R:W91 8.845404
118R:R:W93 6.27833609
119R:R:F95 7.16754397
120R:R:L104 5.3454415
121R:R:M109 4.7375405
122R:R:Y126 5.37333697
123R:R:F127 4.154595
124R:R:R128 6.4645288
125R:R:V130 6.615498
126R:R:H131 5.5175497
127R:R:H133 6.775406
128R:R:H134 4.88494
129R:R:W152 5.1345389
130R:R:C183 4.34254201
131R:R:F197 5.9845158
132R:R:L201 5.2825407
133R:R:R210 3.845494
134R:R:L215 2.8775408
135R:R:M220 4.794273
136R:R:F244 5.021437158
137R:R:R251 6.496676165
138R:R:Y269 4.268502
139R:R:I278 2.82754376
140R:R:M288 4.7654218
141R:R:Y294 5.683336149
142R:R:Y295 5.8065147
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q75 B:B:W99 15.2426.57NoYes299
2B:B:Q75 B:B:Y59 14.83627.89NoYes298
3B:B:W332 B:B:Y59 14.75786.75YesYes298
4B:B:S316 B:B:W332 25.93344.94NoYes099
5B:B:C317 B:B:S316 25.64783.44NoNo079
6B:B:C317 B:B:M61 25.08656.48NoNo076
7B:B:L70 B:B:M61 20.48965.65YesNo056
8B:B:L70 B:B:W82 10.49665.69YesYes459
9A:A:F336 A:A:L194 37.89023.65YesYes684
10A:A:F336 A:A:T340 40.81385.19YesYes086
11A:A:I344 A:A:T340 39.59663.04NoYes066
12A:A:I344 R:R:M220 58.88055.83NoYes063
13R:R:L215 R:R:M220 1002.83YesYes083
14R:R:I226 R:R:L215 72.47342.85NoYes068
15A:A:F354 R:R:I226 72.48843.77YesNo056
16A:A:F354 A:A:K349 95.665413.65YesNo055
17A:A:D261 A:A:K349 95.61162.77NoNo045
18A:A:D261 A:A:T262 95.55744.34NoNo047
19A:A:F259 A:A:T262 87.26736.49YesNo1297
20A:A:F259 A:A:N256 53.30123.62YesNo098
21A:A:N256 A:A:W258 53.15793.39NoYes085
22A:A:W258 B:B:W332 27.52213.75YesYes259
23A:A:L194 R:R:H133 56.59676.43YesYes046
24A:A:T340 R:R:H133 38.22335.48YesYes066
25R:R:H133 R:R:P132 19.11184.58YesNo068
26A:A:I344 R:R:P132 19.21975.08NoNo068
27A:A:T340 R:R:R218 39.64886.47YesNo065
28R:R:M220 R:R:R218 39.68174.96YesNo2735
29A:A:F196 A:A:L194 92.54519.74YesYes674
30A:A:L38 A:A:M198 88.62597.07NoNo087
31A:A:F189 A:A:M198 90.52424.98NoNo097
32A:A:F189 A:A:F196 91.655615NoYes097
33A:A:F215 B:B:W99 14.60054.01NoYes099
34A:A:K46 A:A:L38 86.0914.23YesNo098
35A:A:A41 A:A:S44 82.28043.42NoNo079
36A:A:K46 A:A:S44 83.55163.06YesNo099
37A:A:A41 A:A:S246 81.64433.42NoNo079
38A:A:K277 A:A:Y230 10.56511.94NoYes2598
39A:A:F274 A:A:L227 24.50397.31YesNo097
40A:A:L227 A:A:L268 28.97968.3NoYes078
41A:A:L268 A:A:V225 38.66422.98YesYes087
42A:A:S246 A:A:V225 81.0083.23NoYes097
43A:A:C286 A:A:M243 11.27253.24NoNo068
44A:A:F307 A:A:M243 15.87633.73YesNo088
45A:A:F307 A:A:V225 35.38313.93YesYes087
46A:A:K270 A:A:S228 12.05583.06NoNo099
47A:A:F274 A:A:S228 13.392.64YesNo099
48A:A:K270 A:A:N269 10.72068.39NoNo099
49A:A:F259 A:A:I212 57.92655.02YesNo098
50A:A:I212 A:A:W211 57.79293.52NoYes089
51A:A:S206 A:A:W211 63.81183.71NoYes2489
52A:A:S206 B:B:Y145 70.88613.82NoYes088
53B:B:D186 B:B:Y145 57.80833.45NoYes098
54R:R:R125 R:R:Y294 47.369710.29NoYes1499
55A:A:L353 R:R:R125 47.74248.5YesNo079
56A:A:L348 A:A:L353 48.42112.77NoYes097
57A:A:F354 A:A:L348 23.81717.31YesNo059
58A:A:L348 R:R:V129 28.07882.98NoNo098
59B:B:D186 B:B:G185 57.45861.68NoNo095
60B:B:D205 B:B:G185 57.04181.68NoNo095
61B:B:D205 B:B:S207 56.6357.36NoNo095
62B:B:H183 B:B:S207 56.43162.79YesNo095
63B:B:H183 B:B:K209 29.722311.79YesYes896
64B:B:H183 B:B:S201 22.745.58YesNo899
65B:B:S201 B:B:W211 22.53737.41NoYes898
66B:B:F180 B:B:W211 43.8211.02YesYes878
67B:B:F180 B:B:G216 38.70163.01YesNo074
68B:B:E215 B:B:G216 38.21593.27YesNo034
69B:B:D212 B:B:E215 36.260512.99NoYes1993
70B:B:D212 B:B:R214 35.80294.76NoNo099
71B:B:R197 B:B:R214 35.31534.26NoNo059
72B:B:L198 B:B:R197 31.84524.86NoNo035
73B:B:L198 B:B:L210 31.35645.54NoYes035
74B:B:L210 B:B:Q220 13.96273.99YesYes057
75B:B:K209 B:B:W211 23.0525.8YesYes868
76B:B:D290 B:B:R314 26.228516.68YesNo068
77B:B:C271 B:B:D290 18.97039.34NoYes056
78B:B:C271 B:B:Y289 17.48974.03NoYes057
79B:B:W297 B:B:Y289 13.93277.72YesYes1087
80B:B:W297 B:B:Y264 13.58943.86YesYes085
81B:B:L285 B:B:Y264 10.06245.86NoYes065
82B:B:L308 B:B:M45 13.98254.24NoYes074
83B:B:L308 B:B:W339 10.92667.97NoYes079
84B:B:G162 B:B:Y145 13.93254.35NoYes098
85B:B:G162 B:B:S161 13.66613.71NoYes099
86B:B:H142 B:B:S161 11.211813.95YesYes199
87B:B:H142 B:B:W169 10.14813.17YesYes198
88B:B:L210 B:B:V200 16.45152.98YesYes056
89B:B:I232 B:B:V200 15.46986.14YesYes086
90B:B:N313 B:B:W332 15.56425.65NoYes079
91B:B:D333 B:B:N313 14.99224.04YesNo097
92B:B:D333 B:B:H311 14.12566.3YesYes1199
93R:R:Y294 R:R:Y295 44.10532.98YesYes1497
94R:R:L69 R:R:Y295 43.71823.52NoYes097
95R:R:D290 R:R:L69 43.36074.07NoNo099
96R:R:D290 R:R:N286 25.926612.12NoNo099
97R:R:F244 R:R:N286 25.50488.46YesNo1589
98R:R:F244 R:R:R111 19.71217.48YesNo088
99R:R:F193 R:R:R111 10.154812.83NoNo068
100R:R:D290 R:R:D73 18.86973.99NoNo099
101R:R:D73 R:R:S287 16.31465.89NoNo098
102R:R:L76 R:R:S287 16.10326.01YesNo078
103R:R:L76 R:R:L80 12.92375.54YesNo078
104R:R:L80 R:R:L83 11.43234.15NoNo086
105R:R:E196 R:R:R111 10.324910.47NoNo058
106A:A:W258 B:B:R314 24.74393YesNo258
107R:R:L215 R:R:V129 27.76782.98YesNo088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IJ3
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic Acid
SubType HCA2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.28
Date 2024-01-03
D.O.I. doi.org/10.1038/s41421-023-00610-7
Net Summary
Imin 2.77
Number of Linked Nodes 850
Number of Links 999
Number of Hubs 142
Number of Links mediated by Hubs 534
Number of Communities 42
Number of Nodes involved in Communities 207
Number of Links involved in Communities 265
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 1267998
Length Of Smallest Path 3
Average Path Length 31.5883
Length of Longest Path 57
Minimum Path Strength 1.115
Average Path Strength 5.53336
Maximum Path Strength 20.6
Minimum Path Correlation 0.7
Average Path Correlation 0.984475
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 45.1297
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.2618
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• myeloid cell apoptotic process   • multicellular organismal process   • homeostatic process   • leukocyte apoptotic process   • cell death   • neutrophil homeostasis   • neutrophil apoptotic process   • multicellular organismal-level homeostasis   • leukocyte homeostasis   • immune system process   • inflammatory cell apoptotic process   • cellular process   • homeostasis of number of cells   • apoptotic process   • myeloid cell homeostasis   • programmed cell death   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • system process   • regulation of adiponectin secretion   • positive regulation of establishment of protein localization   • positive regulation of adiponectin secretion   • localization   • adiponectin secretion   • intracellular protein localization   • regulation of biological quality   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • endocrine hormone secretion   • positive regulation of protein localization   • positive regulation of multicellular organismal process   • regulation of hormone secretion   • regulation of protein localization   • transport   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • secretion by cell   • regulation of secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • signal release   • regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of signaling   • secretion   • regulation of transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • positive regulation of protein secretion   • endocrine process   • positive regulation of transport   • protein transport   • macromolecule localization   • hormone transport   • regulation of cell communication   • positive regulation of signaling   • regulation of programmed cell death   • regulation of neutrophil apoptotic process   • positive regulation of myeloid cell apoptotic process   • positive regulation of neutrophil apoptotic process   • regulation of immune system process   • positive regulation of leukocyte apoptotic process   • positive regulation of immune system process   • regulation of leukocyte apoptotic process   • positive regulation of programmed cell death   • regulation of apoptotic process   • positive regulation of apoptotic process   • regulation of myeloid cell apoptotic process   • negative regulation of catabolic process   • lipid catabolic process   • catabolic process   • regulation of lipid metabolic process   • negative regulation of metabolic process   • negative regulation of biological process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • negative regulation of cellular process   • metabolic process   • regulation of metabolic process   • negative regulation of lipid metabolic process   • negative regulation of lipid catabolic process   • lipid metabolic process   • cellular anatomical structure   • cell junction   • cell periphery   • plasma membrane   • membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • nitrogen compound transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • regulation of peptide secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • peptide secretion   • negative regulation of protein localization   • regulation of peptide transport   • peptide transport   • negative regulation of insulin secretion   • regulation of insulin secretion   • peptide hormone secretion   • insulin secretion   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • cell projection   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • plasma membrane bounded cell projection   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • synapse   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8IJ3_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8IJ3_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8IJ3_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDS4
Sequence
>8IJ3_Chain_R
DHFLEIDKK NCCVFRDDF IVKVLPPVL GLEFIFGLL GNGLALWIF 
CFHLKSWKS SRIFLFNLA VADFLLIIC LPFLMDNYV RRWDWKFGD 
IPCRLMLFM LAMNRQGSI IFLTVVAVD RYFRVVHPH HALNKISNR 
TAAIISCLL WGITIGLTV HLLKKKMPI QNGGANLCS SFSICHTFQ 
WHEAMFLLE FFLPLGIIL FCSARIIWS LRQRQMDRH AKIKRAITF 
IMVVAIVFV ICFLPSVVV RIRIFWLLH TSGTQNCEV YRSVDLAFF 
ITLSFTYMN SMLDPVVYY FSSP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK2AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.12023-02-22doi.org/10.1038/s41467-023-37177-6
7XK2 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.12023-02-22doi.org/10.1038/s41467-023-37177-6
7ZL9AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens---2.72023-04-12doi.org/10.1038/s41467-023-37177-6
7ZLYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens---2.72023-04-12doi.org/10.1038/s41467-023-37177-6
8IHFAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.972023-08-30doi.org/10.1038/s41467-023-41650-7
8IHF (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.972023-08-30doi.org/10.1038/s41467-023-41650-7
8IHHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensLUF6283-Gi1/β1/γ23.062023-08-30doi.org/10.1038/s41467-023-41650-7
8IHH (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensLUF6283-3.062023-08-30doi.org/10.1038/s41467-023-41650-7
8IHIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ23.112023-08-30doi.org/10.1038/s41467-023-41650-7
8IHI (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-3.112023-08-30doi.org/10.1038/s41467-023-41650-7
8JHYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens-PubChem 25101223Gi1/β1/γ22.872023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JHY (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens-PubChem 251012232.872023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIIAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 25101223Gi1/β1/γ23.172023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JII (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 251012233.172023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JILAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.52023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIL (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.52023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIMAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-Gi1/β1/γ22.982023-09-06doi.org/10.1016/j.molcel.2023.07.030
8JIM (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-2.982023-09-06doi.org/10.1016/j.molcel.2023.07.030
8IHBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.852023-09-13doi.org/10.1038/s41467-023-41650-7
8IHB (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-2.852023-09-13doi.org/10.1038/s41467-023-41650-7
8JZ7AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.62023-10-04doi.org/10.1038/s41392-023-01625-y
8JZ7 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.62023-10-04doi.org/10.1038/s41392-023-01625-y
8H2GAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.012023-10-11doi.org/10.1038/s41467-023-42764-8
8H2G (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.012023-10-11doi.org/10.1038/s41467-023-42764-8
8K5BAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin--3.432023-11-22doi.org/10.1038/s41467-023-42764-8
8K5CAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox--3.132023-11-22doi.org/10.1038/s41467-023-42764-8
8K5DAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073--3.742023-11-22doi.org/10.1038/s41467-023-42764-8
8IJ3 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiens--3.282024-01-03doi.org/10.1038/s41421-023-00610-7
8IJAAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ22.692024-01-03doi.org/10.1038/s41421-023-00610-7
8IJA (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-2.692024-01-03doi.org/10.1038/s41421-023-00610-7
8IJBAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ23.232024-01-03doi.org/10.1038/s41421-023-00610-7
8IJB (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-3.232024-01-03doi.org/10.1038/s41421-023-00610-7
8IJDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ23.252024-01-03doi.org/10.1038/s41421-023-00610-7
8IJD (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.252024-01-03doi.org/10.1038/s41421-023-00610-7
9IQTAAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-Gi1/β1/γ22.92024-10-02doi.org/10.1016/j.jmb.2024.168795
9IQT (No Gprot) AAlicarboxylic acidHydroxycarboxylic acidHCA2Homo sapiensNiacin-2.92024-10-02doi.org/10.1016/j.jmb.2024.168795
8UTDAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-Gi1/β1/γ23.242025-02-26doi.org/10.1016/j.cell.2024.11.001
8UTD (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-3.242025-02-26doi.org/10.1016/j.cell.2024.11.001
8UUJAAlicarboxylic acidHydroxycarboxylic AcidHCA2Mus musculusFCH-2296413-Gi1/β1/γ22.622025-02-26doi.org/10.1016/j.cell.2024.11.001
8UUJ (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Mus musculusFCH-2296413-2.622025-02-26doi.org/10.1016/j.cell.2024.11.001
9JKYAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ22.722025-10-29To be published
9JKY (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-2.722025-10-29To be published
8J6PAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 25101223Gi1/β1/γ22.552023-12-06doi.org/10.1038/s41467-023-43537-z
8J6P (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacinPubChem 251012232.552023-12-06doi.org/10.1038/s41467-023-43537-z
8J6QAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensβ-HydroxybutyratePubChem 25101223Gi1/β1/γ22.62023-12-06doi.org/10.1038/s41467-023-43537-z
8J6Q (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensβ-HydroxybutyratePubChem 251012232.62023-12-06doi.org/10.1038/s41467-023-43537-z
8J6RAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.762023-12-06doi.org/10.1038/s41467-023-43537-z
8J6R (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.762023-12-06doi.org/10.1038/s41467-023-43537-z
8J6JAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ22.82024-01-10doi.org/10.1016/j.celrep.2023.113406
8J6J (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-2.82024-01-10doi.org/10.1016/j.celrep.2023.113406
8I7VAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Gi1/β1/γ22.772024-02-07doi.org/10.1038/s41467-023-42764-8
8I7V (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-2.772024-02-07doi.org/10.1038/s41467-023-42764-8
8I7WAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Gi1/β1/γ23.392024-02-07doi.org/10.1038/s41467-023-42764-8
8I7W (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-3.392024-02-07doi.org/10.1038/s41467-023-42764-8
8IY9AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Go/β1/γ23.372024-03-06doi.org/10.1038/s41467-024-46239-2
8IY9 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.372024-03-06doi.org/10.1038/s41467-024-46239-2
8IYHAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Go/β1/γ23.32024-03-06doi.org/10.1038/s41467-024-46239-2
8IYH (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-3.32024-03-06doi.org/10.1038/s41467-024-46239-2
8IYWAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-Go/β1/γ23.452024-03-06doi.org/10.1038/s41467-024-46239-2
8IYW (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensGSK256073-3.452024-03-06doi.org/10.1038/s41467-024-46239-2
8JERAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-Go/β1/γ23.452024-03-06doi.org/10.1038/s41467-024-46239-2
8JER (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcipimox-3.452024-03-06doi.org/10.1038/s41467-024-46239-2
8JHNAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-Go/β1/γ23.752024-03-06doi.org/10.1038/s41467-024-46239-2
8JHN (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMonomethyl fumarate-3.752024-03-06doi.org/10.1038/s41467-024-46239-2
8J6IAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.922024-04-03doi.org/10.1016/j.celrep.2023.113406
8J6I (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.922024-04-03doi.org/10.1016/j.celrep.2023.113406
8J6LAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-Gi1/β1/γ23.052024-04-03doi.org/10.1016/j.celrep.2023.113406
8J6L (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensNiacin-3.052024-04-03doi.org/10.1016/j.celrep.2023.113406
9IZAAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensSCH900271-Gi1/β1/γ23.062025-04-02doi.org/10.1371/journal.pbio.3003126
9IZA (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensSCH900271-3.062025-04-02doi.org/10.1371/journal.pbio.3003126
9IZCAAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-Gi1/β1/γ22.682025-04-02doi.org/10.1371/journal.pbio.3003126
9IZC (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK1903-2.682025-04-02doi.org/10.1371/journal.pbio.3003126
9CIBAAlicarboxylic acidHydroxycarboxylic acidHCA2Mus musculusFCH-2296413--2.622025-05-14doi.org/10.1016/j.cell.2024.11.001
9KT7AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-Gi1/β1/γ22.82025-12-1010.1021/acs.jmedchem.4c02567
9KT7 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensMK6892-2.82025-12-1010.1021/acs.jmedchem.4c02567
9KT8AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-Gi1/β1/γ22.732025-12-1010.1021/acs.jmedchem.4c02567
9KT8 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA2Homo sapiensAcifran-2.732025-12-1010.1021/acs.jmedchem.4c02567




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