psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L11	R:R:N171	6.87	No	No	0	8	1
2	R:R:I13	R:R:K16	8.72	Yes	Yes	0	3	4
3	R:R:C18	R:R:I13	4.91	No	Yes	0	9	3
4	R:R:D14	R:R:K15	4.15	No	No	0	5	3
5	R:R:C183	R:R:K16	3.23	No	Yes	0	1	4
6	R:R:K16	R:R:T185	6.01	Yes	No	0	4	2
7	R:R:H184	R:R:N17	6.38	No	No	3	3	5
8	R:R:N17	R:R:T263	4.39	No	No	3	5	3
9	R:R:C18	R:R:C183	7.28	No	No	0	9	1
10	R:R:C19	R:R:C266	3.64	No	Yes	3	4	7
11	R:R:C19	R:R:Y269	4.03	No	Yes	0	4	2
12	R:R:S181	R:R:V20	4.85	No	No	0	4	2
13	R:R:F21	R:R:R270	3.21	No	No	0	2	1
14	R:R:D273	R:R:F21	8.36	No	No	0	4	2
15	R:R:R22	R:R:R90	12.79	Yes	No	0	3	4
16	R:R:D92	R:R:R22	3.57	No	Yes	0	4	3
17	R:R:A174	R:R:R22	4.15	No	Yes	0	2	3
18	R:R:D23	R:R:R270	11.91	No	No	0	4	1
19	R:R:D23	R:R:L274	6.79	No	No	0	4	1
20	R:R:D24	R:R:R90	8.34	No	No	0	4	4
21	R:R:I26	R:R:L274	5.71	No	No	0	5	1
22	R:R:R90	R:R:V27	3.92	No	No	0	4	3
23	R:R:L30	R:R:Y87	3.52	Yes	Yes	0	5	6
24	R:R:L30	R:R:S281	4.5	Yes	No	0	5	6
25	R:R:P31	R:R:P32	7.79	No	No	0	6	5
26	R:R:P31	R:R:V88	3.53	No	No	0	6	3
27	R:R:L34	R:R:L80	5.54	No	No	0	8	8
28	R:R:L34	R:R:M84	5.65	No	No	0	8	7
29	R:R:L34	R:R:S281	4.5	No	No	0	8	6
30	R:R:G35	R:R:M84	3.49	No	No	0	5	7
31	R:R:E37	R:R:M285	10.83	No	No	0	7	5
32	R:R:E37	R:R:M288	4.06	No	Yes	0	7	8
33	R:R:F38	R:R:I39	7.54	No	No	0	7	5
34	R:R:F38	R:R:L42	7.31	No	No	0	7	7
35	R:R:F38	R:R:P81	5.78	No	No	0	7	8
36	R:R:F40	R:R:M288	7.46	No	Yes	0	6	8
37	R:R:G41	R:R:I77	3.53	No	Yes	0	8	6
38	R:R:F74	R:R:N45	4.83	Yes	No	4	7	9
39	R:R:I77	R:R:N45	4.25	Yes	No	4	6	9
40	R:R:N45	R:R:P291	3.26	No	Yes	0	9	9
41	R:R:A70	R:R:L49	3.15	No	No	0	8	7
42	R:R:F74	R:R:L49	4.87	Yes	No	0	7	7
43	R:R:F54	R:R:W50	14.03	No	No	0	4	4
44	R:R:F52	R:R:F67	4.29	No	No	0	7	6
45	R:R:F52	R:R:Y295	5.16	No	Yes	0	7	7
46	R:R:C53	R:R:F54	8.38	No	No	0	4	4
47	R:R:H55	R:R:K57	9.17	No	No	0	5	5
48	R:R:L56	R:R:S58	3	No	No	0	5	6
49	R:R:L56	R:R:W59	6.83	No	No	0	5	6
50	R:R:K60	R:R:S58	6.12	No	No	0	7	6
51	R:R:R63	R:R:S58	7.91	No	No	0	7	6
52	R:R:I64	R:R:W59	4.7	No	No	0	7	6
53	R:R:F67	R:R:W59	6.01	No	No	0	6	6
54	R:R:F65	R:R:S61	5.28	No	No	0	7	6
55	R:R:I139	R:R:S61	3.1	No	No	0	7	6
56	R:R:A144	R:R:S61	3.42	No	No	0	7	6
57	R:R:D124	R:R:S62	4.42	No	No	5	8	8
58	R:R:R128	R:R:S62	5.27	No	No	5	8	8
59	R:R:I64	R:R:N141	8.5	No	No	0	7	2
60	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
61	R:R:L66	R:R:Y295	9.38	No	Yes	2	8	7
62	R:R:F67	R:R:V71	5.24	No	No	0	6	6
63	R:R:F117	R:R:N68	14.5	Yes	No	2	8	9
64	R:R:N68	R:R:S148	4.47	No	No	0	9	8
65	R:R:N68	R:R:W152	6.78	No	Yes	2	9	9
66	R:R:D73	R:R:L69	4.07	Yes	Yes	2	9	9
67	R:R:F117	R:R:L69	3.65	Yes	Yes	2	8	9
68	R:R:L118	R:R:L69	4.15	Yes	Yes	2	9	9
69	R:R:D290	R:R:L69	5.43	Yes	Yes	2	9	9
70	R:R:L69	R:R:Y295	3.52	Yes	Yes	2	9	7
71	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
72	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
73	R:R:D73	R:R:S287	5.89	Yes	No	0	9	8
74	R:R:D290	R:R:D73	6.65	Yes	Yes	2	9	9
75	R:R:F74	R:R:I77	3.77	Yes	Yes	4	7	6
76	R:R:F74	R:R:I78	3.77	Yes	No	0	7	6
77	R:R:L75	R:R:N110	5.49	No	No	0	6	9
78	R:R:L76	R:R:N110	8.24	No	No	0	7	9
79	R:R:I77	R:R:L80	4.28	Yes	No	0	6	8
80	R:R:I77	R:R:S287	3.1	Yes	No	0	6	8
81	R:R:C79	R:R:M103	3.24	No	Yes	1	6	5
82	R:R:C79	R:R:M106	9.73	No	No	0	6	5
83	R:R:C79	R:R:L107	4.76	No	Yes	1	6	6
84	R:R:L83	R:R:Y87	10.55	Yes	Yes	1	6	6
85	R:R:L83	R:R:M103	5.65	Yes	Yes	1	6	5
86	R:R:L107	R:R:L83	5.54	Yes	Yes	1	6	6
87	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
88	L:L:?1	R:R:L83	6.42	Yes	Yes	1	0	6
89	R:R:D85	R:R:F95	4.78	No	No	0	4	7
90	R:R:N86	R:R:W91	6.78	No	Yes	0	5	4
91	R:R:N86	R:R:W93	9.04	No	Yes	0	5	9
92	R:R:W91	R:R:Y87	8.68	Yes	Yes	0	4	6
93	L:L:?1	R:R:Y87	4.35	Yes	Yes	1	0	6
94	R:R:D92	R:R:R89	4.76	No	No	0	4	4
95	R:R:S178	R:R:W91	3.71	No	Yes	0	4	4
96	R:R:F277	R:R:W91	6.01	No	Yes	0	5	4
97	R:R:D92	R:R:K94	6.91	No	No	0	4	3
98	R:R:F95	R:R:W93	22.05	No	Yes	0	7	9
99	R:R:P99	R:R:W93	8.11	No	Yes	0	5	9
100	R:R:C100	R:R:W93	9.14	Yes	Yes	1	9	9
101	R:R:M103	R:R:W93	12.8	Yes	Yes	1	5	9
102	R:R:C177	R:R:W93	19.59	No	Yes	1	9	9
103	R:R:G96	R:R:P99	4.06	No	No	0	7	5
104	R:R:D97	R:R:P168	12.88	No	No	0	3	4
105	R:R:I98	R:R:P99	3.39	No	No	0	2	5
106	R:R:C100	R:R:M167	3.24	Yes	Yes	0	9	3
107	R:R:C100	R:R:P168	11.3	Yes	No	0	9	4
108	R:R:C100	R:R:C177	5.46	Yes	No	1	9	9
109	R:R:L107	R:R:M103	4.24	Yes	Yes	1	6	5
110	R:R:C177	R:R:M103	3.24	No	Yes	1	9	5
111	R:R:L104	R:R:M167	4.24	No	Yes	0	5	3
112	R:R:L104	R:R:S179	6.01	No	No	0	5	4
113	R:R:F105	R:R:M109	9.95	No	Yes	0	6	5
114	R:R:F105	R:R:T159	5.19	No	No	0	6	7
115	R:R:F105	R:R:L163	12.18	No	No	0	6	5
116	R:R:L107	R:R:Y284	5.86	Yes	Yes	1	6	7
117	L:L:?1	R:R:L107	10.27	Yes	Yes	1	0	6
118	R:R:M109	R:R:N110	4.21	Yes	No	0	5	9
119	R:R:M109	R:R:W152	3.49	Yes	Yes	0	5	9
120	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
121	R:R:F180	R:R:R111	3.21	Yes	Yes	1	3	8
122	R:R:E196	R:R:R111	4.65	Yes	Yes	0	5	8
123	R:R:R111	R:R:T283	6.47	Yes	No	0	8	8
124	R:R:R111	R:R:Y284	4.12	Yes	Yes	1	8	7
125	L:L:?1	R:R:R111	13.52	Yes	Yes	1	0	8
126	R:R:L158	R:R:Q112	5.32	No	No	0	5	7
127	R:R:M192	R:R:Q112	6.8	No	No	0	5	7
128	R:R:E196	R:R:Q112	10.19	Yes	No	0	5	7
129	R:R:G113	R:R:T155	3.64	No	No	0	7	7
130	R:R:E196	R:R:I115	4.1	Yes	No	0	5	8
131	R:R:I115	R:R:P200	3.39	No	No	0	8	9
132	R:R:F244	R:R:I115	8.79	No	No	0	8	8
133	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
134	R:R:I116	R:R:T155	4.56	No	No	0	5	7
135	R:R:F117	R:R:L151	4.87	Yes	Yes	0	8	7
136	R:R:F117	R:R:W152	10.02	Yes	Yes	2	8	9
137	R:R:L118	R:R:N286	4.12	Yes	No	2	9	9
138	R:R:D290	R:R:L118	4.07	Yes	Yes	2	9	9
139	R:R:L118	R:R:Y294	9.38	Yes	Yes	2	9	9
140	R:R:P200	R:R:T119	6.99	No	No	0	9	7
141	R:R:I203	R:R:T119	6.08	No	No	0	7	7
142	R:R:I204	R:R:T119	3.04	No	No	0	8	7
143	R:R:L151	R:R:V120	4.47	Yes	No	0	7	7
144	R:R:V121	R:R:Y294	3.79	No	Yes	0	9	9
145	R:R:D124	R:R:R128	11.91	No	No	5	8	8
146	R:R:R125	R:R:Y294	8.23	No	Yes	0	9	9
147	R:R:V130	R:R:Y126	10.09	No	Yes	0	8	7
148	R:R:F206	R:R:Y126	3.09	No	Yes	6	4	7
149	R:R:C207	R:R:Y126	6.72	No	Yes	0	8	7
150	R:R:R210	R:R:Y126	7.2	No	Yes	6	4	7
151	R:R:F127	R:R:H134	11.31	No	No	0	5	4
152	R:R:I211	R:R:V129	10.75	No	No	0	8	8
153	R:R:L215	R:R:V129	4.47	No	No	0	8	8
154	R:R:H131	R:R:V130	4.15	No	No	0	7	8
155	R:R:S214	R:R:V130	4.85	No	No	0	5	8
156	R:R:H133	R:R:P132	6.1	No	No	0	6	8
157	R:R:P132	R:R:R218	4.32	No	No	0	8	5
158	R:R:I139	R:R:T143	6.08	No	No	0	7	3
159	R:R:S140	R:R:T143	6.4	No	No	0	6	3
160	R:R:G153	R:R:I156	3.53	No	No	0	4	4
161	R:R:L158	R:R:W188	3.42	No	No	0	5	5
162	R:R:L163	R:R:V160	4.47	No	No	0	5	4
163	R:R:K164	R:R:V160	3.04	No	No	0	4	4
164	R:R:H161	R:R:L162	9	No	No	1	7	4
165	R:R:H161	R:R:W188	3.17	No	No	0	7	5
166	R:R:H161	R:R:H189	3.58	No	Yes	1	7	5
167	R:R:H189	R:R:L162	3.86	Yes	No	1	5	4
168	R:R:K165	R:R:M167	7.2	No	Yes	0	4	3
169	R:R:N175	R:R:Q170	10.56	No	No	0	4	1
170	R:R:L176	R:R:N171	4.12	No	No	0	4	1
171	R:R:L176	R:R:S178	4.5	No	No	0	4	4
172	R:R:H189	R:R:S179	8.37	Yes	No	0	5	4
173	L:L:?1	R:R:S179	8.35	Yes	No	0	0	4
174	R:R:F180	R:R:H189	9.05	Yes	Yes	1	3	5
175	R:R:F180	R:R:F193	16.08	Yes	No	0	3	6
176	R:R:F180	R:R:R251	5.34	Yes	No	1	3	5
177	R:R:F180	R:R:F276	3.22	Yes	Yes	1	3	4
178	R:R:F180	R:R:L280	7.31	Yes	No	1	3	5
179	L:L:?1	R:R:F180	6.77	Yes	Yes	1	0	3
180	R:R:I182	R:R:I254	5.89	No	No	0	3	4
181	R:R:H184	R:R:T263	4.11	No	No	3	3	3
182	R:R:F186	R:R:F255	5.36	No	No	0	4	5
183	R:R:M192	R:R:W188	10.47	No	No	0	5	5
184	R:R:H189	R:R:M192	3.94	Yes	No	0	5	5
185	R:R:E190	R:R:R251	11.63	No	No	0	4	5
186	R:R:E190	R:R:F255	13.99	No	No	0	4	5
187	R:R:E196	R:R:F193	4.66	Yes	No	0	5	6
188	R:R:F193	R:R:S247	5.28	No	Yes	0	6	6
189	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
190	R:R:F197	R:R:L201	7.31	Yes	No	0	8	7
191	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
192	R:R:F197	R:R:V248	15.73	Yes	No	0	8	8
193	R:R:F240	R:R:L201	3.65	No	No	0	9	7
194	R:R:F240	R:R:I204	6.28	No	No	0	9	8
195	R:R:F206	R:R:R210	8.55	No	No	6	4	4
196	R:R:I233	R:R:S208	3.1	No	No	0	7	8
197	R:R:R210	R:R:W213	7	No	No	0	4	3
198	R:R:I212	R:R:R216	6.26	No	No	0	5	4
199	R:R:I212	R:R:I230	5.89	No	No	0	5	6
200	R:R:I230	R:R:L215	4.28	No	No	0	6	8
201	R:R:M220	R:R:R218	3.72	No	No	0	3	5
202	R:R:H223	R:R:I226	5.3	No	No	0	4	6
203	R:R:F232	R:R:R228	3.21	Yes	No	0	7	7
204	R:R:P299	R:R:R228	4.32	No	No	0	5	7
205	R:R:F232	R:R:V235	3.93	Yes	No	0	7	5
206	R:R:F232	R:R:V293	5.24	Yes	No	0	7	8
207	R:R:F232	R:R:S297	13.21	Yes	No	0	7	6
208	R:R:V236	R:R:V293	3.21	No	No	0	8	8
209	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
210	R:R:F240	R:R:F244	13.93	No	No	0	9	8
211	R:R:F244	R:R:T283	7.78	No	No	0	8	8
212	R:R:P246	R:R:T279	3.5	No	Yes	0	9	7
213	R:R:F276	R:R:S247	6.61	Yes	Yes	1	4	6
214	R:R:S247	R:R:T279	4.8	Yes	Yes	1	6	7
215	R:R:L280	R:R:S247	3	No	Yes	1	5	6
216	R:R:I252	R:R:V248	3.07	No	No	0	6	8
217	R:R:F276	R:R:V250	6.55	Yes	No	1	4	5
218	R:R:T279	R:R:V250	3.17	Yes	No	1	7	5
219	R:R:F276	R:R:R251	12.83	Yes	No	1	4	5
220	R:R:I254	R:R:Y269	4.84	No	Yes	0	4	2
221	R:R:I254	R:R:V272	4.61	No	No	0	4	4
222	R:R:L257	R:R:W256	4.56	No	No	0	3	4
223	R:R:T260	R:R:W256	6.06	No	No	0	1	4
224	R:R:L258	R:R:Y269	3.52	No	Yes	0	3	2
225	R:R:S261	R:R:T260	4.8	No	No	0	3	1
226	R:R:E267	R:R:N265	5.26	No	No	0	2	5
227	R:R:N265	R:R:V268	7.39	No	No	0	5	1
228	R:R:C266	R:R:E267	6.08	Yes	No	0	7	2
229	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
230	R:R:D273	R:R:F277	5.97	No	No	0	4	5
231	R:R:F276	R:R:F277	6.43	Yes	No	0	4	5
232	R:R:F276	R:R:T279	3.89	Yes	Yes	1	4	7
233	L:L:?1	R:R:L280	11.55	Yes	No	1	0	5
234	R:R:S281	R:R:Y284	3.82	No	Yes	0	6	7
235	L:L:?1	R:R:Y284	9.78	Yes	Yes	1	0	7
236	R:R:D290	R:R:N286	12.12	Yes	No	2	9	9
237	R:R:L289	R:R:M288	4.24	No	Yes	0	7	8
238	R:R:D290	R:R:Y294	5.75	Yes	Yes	2	9	9
239	R:R:P291	R:R:Y295	4.17	Yes	Yes	0	9	7
240	R:R:F296	R:R:P291	4.33	No	Yes	0	8	9
241	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
242	R:R:L289	R:R:V239	2.98	No	No	0	7	7
243	R:R:L245	R:R:V241	2.98	No	No	0	6	5
244	R:R:L245	R:R:V249	2.98	No	No	0	6	6
245	R:R:I211	R:R:I233	2.94	No	No	0	8	7
246	R:R:I238	R:R:I242	2.94	No	No	0	5	5
247	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
248	R:R:E37	R:R:V33	2.85	No	No	0	7	5
249	R:R:I51	R:R:L56	2.85	No	No	0	7	5
250	R:R:I98	R:R:L102	2.85	No	No	0	2	5
251	R:R:I169	R:R:L176	2.85	No	No	0	1	4
252	R:R:L215	R:R:M220	2.83	No	No	0	8	3
253	R:R:C266	R:R:F21	2.79	Yes	No	0	7	2
254	R:R:A191	R:R:F186	2.77	No	No	0	3	4
255	R:R:K16	R:R:Q187	2.71	Yes	No	0	4	2
256	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
257	R:R:H223	R:R:M220	2.63	No	No	0	4	3
258	R:R:F65	R:R:V120	2.62	No	No	0	7	7
259	R:R:F127	R:R:V123	2.62	No	No	0	5	6
260	R:R:F10	R:R:T263	2.59	Yes	No	3	7	3
261	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
262	R:R:H134	R:R:L136	2.57	No	No	0	4	4
263	R:R:H134	R:R:N137	2.55	No	No	0	4	4
264	R:R:F65	R:R:I147	2.51	No	No	0	7	5
265	R:R:F282	R:R:M285	2.49	No	No	0	7	5
266	R:R:M167	R:R:R101	2.48	Yes	No	0	3	6
267	R:R:L257	R:R:R253	2.43	No	No	0	3	5
268	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
269	R:R:N137	R:R:R128	2.41	No	No	0	4	8
270	R:R:D221	R:R:R216	2.38	No	No	0	3	4
271	R:R:F82	R:R:F95	2.14	No	No	0	6	7
272	R:R:G172	R:R:G173	2.11	No	No	7	3	4
273	R:R:F127	R:R:Y126	2.06	No	Yes	0	5	7
274	R:R:G44	R:R:P291	2.03	No	Yes	0	7	9
275	R:R:R22	R:R:W91	2	Yes	Yes	0	3	4
276	R:R:G262	R:R:S261	1.86	No	No	0	4	3
277	R:R:G157	R:R:V160	1.84	No	No	0	5	4
278	R:R:A122	R:R:C207	1.81	No	No	0	9	8
279	R:R:P299	R:R:S298	1.78	No	No	0	5	8
280	R:R:G41	R:R:M288	1.75	No	Yes	0	8	8
281	R:R:G44	R:R:L43	1.71	No	No	0	7	4
282	R:R:A145	R:R:S148	1.71	No	No	0	3	8
283	R:R:G202	R:R:L201	1.71	No	No	0	3	7
284	R:R:A237	R:R:S208	1.71	No	No	0	7	8
285	R:R:C243	R:R:V239	1.71	No	No	0	8	7
286	R:R:G262	R:R:L258	1.71	No	No	0	4	3
287	R:R:A108	R:R:T159	1.68	No	No	0	4	7
288	R:R:K225	R:R:P299	1.67	No	No	0	5	5
289	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
290	R:R:L80	R:R:P81	1.64	No	No	0	8	8
291	R:R:G172	R:R:Q170	1.64	No	No	7	3	1
292	R:R:G173	R:R:Q170	1.64	No	No	7	4	1
293	R:R:L199	R:R:P200	1.64	No	No	0	4	9
294	R:R:C207	R:R:I203	1.64	No	No	0	8	7
295	R:R:G262	R:R:Q264	1.64	No	No	0	4	3
296	R:R:V29	R:R:V33	1.6	No	No	0	5	5
297	R:R:V292	R:R:V293	1.6	No	No	0	6	8
298	R:R:A191	R:R:L195	1.58	No	No	0	3	4
299	R:R:I182	R:R:V20	1.54	No	No	0	3	2
300	R:R:L194	R:R:V248	1.49	No	No	0	4	8
301	R:R:I13	R:R:I169	1.47	Yes	No	0	3	1
302	R:R:I154	R:R:L150	1.43	No	No	0	5	4
303	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
304	R:R:I154	R:R:L158	1.43	No	No	0	5	5
305	R:R:C19	R:R:F10	1.4	No	Yes	3	4	7
306	R:R:C266	R:R:F10	1.4	Yes	Yes	3	7	7
307	R:R:D14	R:R:I13	1.4	No	Yes	0	5	3
308	R:R:R142	R:R:S140	1.32	No	No	0	4	6
309	R:R:E12	R:R:N17	1.31	No	No	0	5	5
310	R:R:D221	R:R:Q219	1.31	No	No	0	3	3
311	R:R:F232	R:R:T231	1.3	Yes	No	0	7	6
312	R:R:I146	R:R:R142	1.25	No	No	0	3	4
313	R:R:F296	R:R:L47	1.22	No	No	0	8	6
314	R:R:Q219	R:R:R222	1.17	No	No	0	3	3
315	R:R:F10	R:R:H9	1.13	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F10	1.63	4	3	7
2	R:R:I13	4.125	4	0	3
3	R:R:K16	5.1675	4	0	4
4	R:R:R22	5.6275	4	0	3
5	R:R:L30	3.1275	4	0	5
6	R:R:L69	4.164	5	2	9
7	R:R:D73	5.625	4	2	9
8	R:R:F74	4.31	4	4	7
9	R:R:I77	3.786	5	4	6
10	R:R:L83	6.336	5	1	6
11	R:R:Y87	6.775	4	1	6
12	R:R:W91	5.436	5	0	4
13	R:R:W93	13.455	6	1	9
14	R:R:C100	7.285	4	1	9
15	R:R:M103	5.834	5	1	5
16	R:R:L107	6.134	5	1	6
17	R:R:M109	5.505	4	0	5
18	R:R:R111	6.394	5	1	8
19	R:R:F117	8.26	4	2	8
20	R:R:L118	5.43	4	2	9
21	R:R:Y126	5.26333	6	6	7
22	R:R:L151	4.12	4	0	7
23	R:R:W152	5.72	4	2	9
24	R:R:M167	4.29	4	0	3
25	R:R:F180	7.28286	7	1	3
26	R:R:H189	5.76	5	1	5
27	R:R:E196	5.9	4	0	5
28	R:R:F197	8.89	4	0	8
29	R:R:F232	5.378	5	0	7
30	R:R:S247	4.9225	4	1	6
31	R:R:C266	3.4775	4	3	7
32	R:R:Y269	4.045	4	0	2
33	R:R:F276	6.58833	6	1	4
34	R:R:T279	3.84	4	1	7
35	R:R:Y284	5.42	5	1	7
36	R:R:M288	4.3775	4	0	8
37	R:R:D290	6.804	5	2	9
38	R:R:P291	3.4475	4	0	9
39	R:R:Y294	6.03	7	2	9
40	R:R:Y295	4.88714	7	2	7
41	L:L:?1	8.87625	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I13	R:R:I169	10.9632	1.47	Yes	No	0	3	1
2	R:R:I169	R:R:L176	12.1757	2.85	No	No	0	1	4
3	R:R:C266	R:R:F10	14.0896	1.4	Yes	Yes	3	7	7
4	R:R:C266	R:R:F21	60.1605	2.79	Yes	No	0	7	2
5	R:R:D273	R:R:F21	71.0477	8.36	No	No	0	4	2
6	R:R:D273	R:R:F277	72.9869	5.97	No	No	0	4	5
7	R:R:F277	R:R:W91	22.2349	6.01	No	Yes	0	5	4
8	R:R:S178	R:R:W91	16.7554	3.71	No	Yes	0	4	4
9	R:R:L176	R:R:S178	15.7499	4.5	No	No	0	4	4
10	R:R:C19	R:R:C266	36.9328	3.64	No	Yes	3	4	7
11	R:R:C19	R:R:Y269	35.0148	4.03	No	Yes	0	4	2
12	R:R:I254	R:R:Y269	11.7237	4.84	No	Yes	0	4	2
13	R:R:R22	R:R:W91	10.0338	2	Yes	Yes	0	3	4
14	R:R:W91	R:R:Y87	35.2471	8.68	Yes	Yes	0	4	6
15	R:R:L30	R:R:Y87	23.8276	3.52	Yes	Yes	0	5	6
16	R:R:L30	R:R:S281	23.2108	4.5	Yes	No	0	5	6
17	R:R:L34	R:R:S281	52.5982	4.5	No	No	0	8	6
18	R:R:L34	R:R:L80	51.2421	5.54	No	No	0	8	8
19	R:R:G41	R:R:M288	13.2193	1.75	No	Yes	0	8	8
20	R:R:G41	R:R:I77	14.4951	3.53	No	Yes	0	8	6
21	R:R:I77	R:R:L80	48.8973	4.28	Yes	No	0	6	8
22	R:R:I77	R:R:N45	22.4292	4.25	Yes	No	4	6	9
23	R:R:N45	R:R:P291	22.4461	3.26	No	Yes	0	9	9
24	R:R:F52	R:R:Y295	16.2738	5.16	No	Yes	0	7	7
25	R:R:P291	R:R:Y295	20.5027	4.17	Yes	Yes	0	9	7
26	R:R:F52	R:R:F67	15.0401	4.29	No	No	0	7	6
27	R:R:F67	R:R:W59	12.1926	6.01	No	No	0	6	6
28	R:R:F65	R:R:V120	20.583	2.62	No	No	0	7	7
29	R:R:L151	R:R:V120	22.6362	4.47	Yes	No	0	7	7
30	R:R:I154	R:R:L151	97.3891	1.43	No	Yes	0	5	7
31	R:R:I154	R:R:L158	100	1.43	No	No	0	5	5
32	R:R:L158	R:R:Q112	76.3371	5.32	No	No	0	5	7
33	R:R:E196	R:R:Q112	66.1639	10.19	Yes	No	0	5	7
34	R:R:E196	R:R:R111	56.5737	4.65	Yes	Yes	0	5	8
35	L:L:?1	R:R:R111	26.1132	13.52	Yes	Yes	1	0	8
36	L:L:?1	R:R:Y87	15.264	4.35	Yes	Yes	1	0	6
37	R:R:F65	R:R:S61	16.2188	5.28	No	No	0	7	6
38	R:R:I139	R:R:S61	11.5294	3.1	No	No	0	7	6
39	R:R:F127	R:R:H134	11.1196	11.31	No	No	0	5	4
40	R:R:F127	R:R:Y126	14.8416	2.06	No	Yes	0	5	7
41	R:R:C207	R:R:Y126	58.0735	6.72	No	Yes	0	8	7
42	R:R:C207	R:R:I203	61.335	1.64	No	No	0	8	7
43	R:R:I203	R:R:T119	62.9531	6.08	No	No	0	7	7
44	R:R:P200	R:R:T119	62.9404	6.99	No	No	0	9	7
45	R:R:I115	R:R:P200	66.0076	3.39	No	No	0	8	9
46	R:R:E196	R:R:I115	73.0841	4.1	Yes	No	0	5	8
47	R:R:Y294	R:R:Y295	19.8817	3.97	Yes	Yes	2	9	7
48	R:R:I77	R:R:S287	17.5877	3.1	Yes	No	0	6	8
49	R:R:D73	R:R:S287	16.9582	5.89	Yes	No	0	9	8
50	R:R:D290	R:R:D73	10.5154	6.65	Yes	Yes	2	9	9
51	R:R:D290	R:R:Y294	18.8255	5.75	Yes	Yes	2	9	9
52	R:R:F117	R:R:L151	79.3071	4.87	Yes	Yes	0	8	7
53	R:R:F117	R:R:W152	34.4698	10.02	Yes	Yes	2	8	9
54	R:R:L118	R:R:L69	12.8095	4.15	Yes	Yes	2	9	9
55	R:R:M109	R:R:W152	30.1479	3.49	Yes	Yes	0	5	9
56	R:R:L83	R:R:M103	18.5678	5.65	Yes	Yes	1	6	5
57	R:R:M103	R:R:W93	25.9442	12.8	Yes	Yes	1	5	9
58	R:R:L83	R:R:Y284	11.673	3.52	Yes	Yes	1	6	7
59	R:R:P99	R:R:W93	11.6223	8.11	No	Yes	0	5	9
60	R:R:L104	R:R:S179	11.2505	6.01	No	No	0	5	4
61	R:R:F105	R:R:M109	16.409	9.95	No	Yes	0	6	5
62	R:R:F180	R:R:F276	50.583	3.22	Yes	Yes	1	3	4
63	R:R:F276	R:R:F277	58.0059	6.43	Yes	No	0	4	5
64	R:R:R111	R:R:T283	12.5433	6.47	Yes	No	0	8	8
65	R:R:H189	R:R:S179	10.4563	8.37	Yes	No	0	5	4
66	R:R:H189	R:R:M192	26.4385	3.94	Yes	No	0	5	5
67	R:R:F180	R:R:H189	32.5982	9.05	Yes	Yes	1	3	5
68	R:R:F244	R:R:T283	11.4153	7.78	No	No	0	8	8
69	R:R:F240	R:R:F244	16.2695	13.93	No	No	0	9	8
70	R:R:I211	R:R:Y126	32.725	2.42	No	Yes	0	8	7
71	R:R:I211	R:R:V129	25.7921	10.75	No	No	0	8	8
72	R:R:L215	R:R:V129	23.9882	4.47	No	No	0	8	8
73	R:R:L215	R:R:M220	11.3435	2.83	No	No	0	8	3
74	R:R:H161	R:R:H189	14.4191	3.58	No	Yes	1	7	5
75	R:R:H161	R:R:W188	14.06	3.17	No	No	0	7	5
76	R:R:M192	R:R:W188	13.6629	10.47	No	No	0	5	5
77	R:R:F180	R:R:F193	17.8285	16.08	Yes	No	0	3	6
78	R:R:F193	R:R:S247	15.4668	5.28	No	Yes	0	6	6
79	R:R:F276	R:R:S247	12.9911	6.61	Yes	Yes	1	4	6
80	R:R:F186	R:R:F255	10.7562	5.36	No	No	0	4	5
81	R:R:E190	R:R:F255	14.4867	13.99	No	No	0	4	5
82	R:R:E190	R:R:R251	18.0439	11.63	No	No	0	4	5
83	R:R:F197	R:R:L201	12.0955	7.31	Yes	No	0	8	7
84	R:R:F240	R:R:L201	15.0359	3.65	No	No	0	9	7
85	R:R:I230	R:R:L215	11.1238	4.28	No	No	0	6	8
86	R:R:F232	R:R:V293	28.0144	5.24	Yes	No	0	7	8
87	R:R:V236	R:R:V293	35.0739	3.21	No	No	0	8	8
88	R:R:V236	R:R:Y294	38.3523	7.57	No	Yes	0	8	9
89	R:R:F232	R:R:R228	13.8065	3.21	Yes	No	0	7	7
90	R:R:P299	R:R:R228	10.2281	4.32	No	No	0	5	7
91	R:R:L258	R:R:Y269	19.079	3.52	No	Yes	0	3	2
92	R:R:G262	R:R:L258	16.9117	1.71	No	No	0	4	3
93	R:R:G262	R:R:S261	12.1208	1.86	No	No	0	4	3
94	R:R:M192	R:R:Q112	13.7896	6.8	No	No	0	5	7
95	R:R:L158	R:R:W188	25.8724	3.42	No	No	0	5	5
96	R:R:F180	R:R:R111	23.8868	3.21	Yes	Yes	1	3	8
97	R:R:E196	R:R:F193	32.9066	4.66	Yes	No	0	5	6
98	R:R:F117	R:R:L69	52.4166	3.65	Yes	Yes	2	8	9
99	R:R:R111	R:R:Y284	26.4343	4.12	Yes	Yes	1	8	7
100	R:R:S281	R:R:Y284	33.1686	3.82	No	Yes	0	6	7
101	R:R:L107	R:R:Y284	13.0292	5.86	Yes	Yes	1	6	7
102	R:R:F180	R:R:R251	19.5184	5.34	Yes	No	1	3	5
103	R:R:L107	R:R:M103	17.4102	4.24	Yes	Yes	1	6	5
104	R:R:L69	R:R:Y295	23.4305	3.52	Yes	Yes	2	9	7
105	R:R:L118	R:R:Y294	10.0211	9.38	Yes	Yes	2	9	9
106	R:R:D290	R:R:L69	11.4575	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:Y87	3.52	0	Yes	Yes	5	6	2	1
R:R:L30	R:R:S281	4.5	0	Yes	No	5	6	2	2
R:R:C79	R:R:M103	3.24	1	No	Yes	6	5	2	2
R:R:C79	R:R:L107	4.76	1	No	Yes	6	6	2	1
R:R:L83	R:R:Y87	10.55	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:M103	5.65	1	Yes	Yes	6	5	1	2
R:R:L107	R:R:L83	5.54	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L83	6.42	1	Yes	Yes	0	6	0	1
R:R:W91	R:R:Y87	8.68	0	Yes	Yes	4	6	2	1
L:L:?1	R:R:Y87	4.35	1	Yes	Yes	0	6	0	1
R:R:L107	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L104	R:R:S179	6.01	0	No	No	5	4	2	1
R:R:L107	R:R:Y284	5.86	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	10.27	1	Yes	Yes	0	6	0	1
R:R:F180	R:R:R111	3.21	1	Yes	Yes	3	8	1	1
R:R:E196	R:R:R111	4.65	0	Yes	Yes	5	8	2	1
R:R:R111	R:R:T283	6.47	1	Yes	No	8	8	1	2
R:R:R111	R:R:Y284	4.12	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:R111	13.52	1	Yes	Yes	0	8	0	1
R:R:H189	R:R:S179	8.37	1	Yes	No	5	4	2	1
L:L:?1	R:R:S179	8.35	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	16.08	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	5.34	1	Yes	No	3	5	1	2
R:R:F180	R:R:F276	3.22	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	7.31	1	Yes	No	3	5	1	1
L:L:?1	R:R:F180	6.77	1	Yes	Yes	0	3	0	1
R:R:E196	R:R:F193	4.66	0	Yes	No	5	6	2	2
R:R:F193	R:R:S247	5.28	0	No	Yes	6	6	2	2
R:R:F276	R:R:S247	6.61	1	Yes	Yes	4	6	2	2
R:R:L280	R:R:S247	3	1	No	Yes	5	6	1	2
R:R:F276	R:R:R251	12.83	1	Yes	No	4	5	2	2
L:L:?1	R:R:L280	11.55	1	Yes	No	0	5	0	1
R:R:S281	R:R:Y284	3.82	0	No	Yes	6	7	2	1
L:L:?1	R:R:Y284	9.78	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H2G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	274
Number of Links	315
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	107
Number Of Links MetaPath	106
Number of Shortest Paths	65783
Length Of Smallest Path	3
Average Path Length	14.1736
Length of Longest Path	32
Minimum Path Strength	1.24
Average Path Strength	5.35185
Maximum Path Strength	20.82
Minimum Path Correlation	0.7
Average Path Correlation	0.921202
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.8708
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3208
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	pyridine-β-carboxylic acid
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	117629482
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8H2G_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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