psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L11	R:R:N171	6.87	No	No	0	8	1
2	R:R:I13	R:R:K16	8.72	Yes	Yes	0	3	4
3	R:R:C18	R:R:I13	4.91	No	Yes	0	9	3
4	R:R:D14	R:R:K15	4.15	No	No	0	5	3
5	R:R:C183	R:R:K16	3.23	No	Yes	0	1	4
6	R:R:K16	R:R:T185	6.01	Yes	No	0	4	2
7	R:R:H184	R:R:N17	6.38	No	No	3	3	5
8	R:R:N17	R:R:T263	4.39	No	No	3	5	3
9	R:R:C18	R:R:C183	7.28	No	No	0	9	1
10	R:R:C19	R:R:C266	3.64	No	Yes	3	4	7
11	R:R:C19	R:R:Y269	4.03	No	Yes	0	4	2
12	R:R:S181	R:R:V20	4.85	No	No	0	4	2
13	R:R:F21	R:R:R270	3.21	No	No	0	2	1
14	R:R:D273	R:R:F21	8.36	No	No	0	4	2
15	R:R:R22	R:R:R90	12.79	Yes	No	0	3	4
16	R:R:D92	R:R:R22	3.57	No	Yes	0	4	3
17	R:R:A174	R:R:R22	4.15	No	Yes	0	2	3
18	R:R:D23	R:R:R270	11.91	No	No	0	4	1
19	R:R:D23	R:R:L274	6.79	No	No	0	4	1
20	R:R:D24	R:R:R90	8.34	No	No	0	4	4
21	R:R:I26	R:R:L274	5.71	No	No	0	5	1
22	R:R:R90	R:R:V27	3.92	No	No	0	4	3
23	R:R:L30	R:R:Y87	3.52	Yes	Yes	0	5	6
24	R:R:L30	R:R:S281	4.5	Yes	No	0	5	6
25	R:R:P31	R:R:P32	7.79	No	No	0	6	5
26	R:R:P31	R:R:V88	3.53	No	No	0	6	3
27	R:R:L34	R:R:L80	5.54	No	No	0	8	8
28	R:R:L34	R:R:M84	5.65	No	No	0	8	7
29	R:R:L34	R:R:S281	4.5	No	No	0	8	6
30	R:R:G35	R:R:M84	3.49	No	No	0	5	7
31	R:R:E37	R:R:M285	10.83	No	No	0	7	5
32	R:R:E37	R:R:M288	4.06	No	Yes	0	7	8
33	R:R:F38	R:R:I39	7.54	No	No	0	7	5
34	R:R:F38	R:R:L42	7.31	No	No	0	7	7
35	R:R:F38	R:R:P81	5.78	No	No	0	7	8
36	R:R:F40	R:R:M288	7.46	No	Yes	0	6	8
37	R:R:G41	R:R:I77	3.53	No	Yes	0	8	6
38	R:R:F74	R:R:N45	4.83	Yes	No	4	7	9
39	R:R:I77	R:R:N45	4.25	Yes	No	4	6	9
40	R:R:N45	R:R:P291	3.26	No	Yes	0	9	9
41	R:R:A70	R:R:L49	3.15	No	No	0	8	7
42	R:R:F74	R:R:L49	4.87	Yes	No	0	7	7
43	R:R:F54	R:R:W50	14.03	No	No	0	4	4
44	R:R:F52	R:R:F67	4.29	No	No	0	7	6
45	R:R:F52	R:R:Y295	5.16	No	Yes	0	7	7
46	R:R:C53	R:R:F54	8.38	No	No	0	4	4
47	R:R:H55	R:R:K57	9.17	No	No	0	5	5
48	R:R:L56	R:R:S58	3	No	No	0	5	6
49	R:R:L56	R:R:W59	6.83	No	No	0	5	6
50	R:R:K60	R:R:S58	6.12	No	No	0	7	6
51	R:R:R63	R:R:S58	7.91	No	No	0	7	6
52	R:R:I64	R:R:W59	4.7	No	No	0	7	6
53	R:R:F67	R:R:W59	6.01	No	No	0	6	6
54	R:R:F65	R:R:S61	5.28	No	No	0	7	6
55	R:R:I139	R:R:S61	3.1	No	No	0	7	6
56	R:R:A144	R:R:S61	3.42	No	No	0	7	6
57	R:R:D124	R:R:S62	4.42	No	No	5	8	8
58	R:R:R128	R:R:S62	5.27	No	No	5	8	8
59	R:R:I64	R:R:N141	8.5	No	No	0	7	2
60	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
61	R:R:L66	R:R:Y295	9.38	No	Yes	2	8	7
62	R:R:F67	R:R:V71	5.24	No	No	0	6	6
63	R:R:F117	R:R:N68	14.5	Yes	No	2	8	9
64	R:R:N68	R:R:S148	4.47	No	No	0	9	8
65	R:R:N68	R:R:W152	6.78	No	Yes	2	9	9
66	R:R:D73	R:R:L69	4.07	Yes	Yes	2	9	9
67	R:R:F117	R:R:L69	3.65	Yes	Yes	2	8	9
68	R:R:L118	R:R:L69	4.15	Yes	Yes	2	9	9
69	R:R:D290	R:R:L69	5.43	Yes	Yes	2	9	9
70	R:R:L69	R:R:Y295	3.52	Yes	Yes	2	9	7
71	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	7
72	R:R:D73	R:R:S114	5.89	Yes	No	0	9	9
73	R:R:D73	R:R:S287	5.89	Yes	No	0	9	8
74	R:R:D290	R:R:D73	6.65	Yes	Yes	2	9	9
75	R:R:F74	R:R:I77	3.77	Yes	Yes	4	7	6
76	R:R:F74	R:R:I78	3.77	Yes	No	0	7	6
77	R:R:L75	R:R:N110	5.49	No	No	0	6	9
78	R:R:L76	R:R:N110	8.24	No	No	0	7	9
79	R:R:I77	R:R:L80	4.28	Yes	No	0	6	8
80	R:R:I77	R:R:S287	3.1	Yes	No	0	6	8
81	R:R:C79	R:R:M103	3.24	No	Yes	1	6	5
82	R:R:C79	R:R:M106	9.73	No	No	0	6	5
83	R:R:C79	R:R:L107	4.76	No	Yes	1	6	6
84	R:R:L83	R:R:Y87	10.55	Yes	Yes	1	6	6
85	R:R:L83	R:R:M103	5.65	Yes	Yes	1	6	5
86	R:R:L107	R:R:L83	5.54	Yes	Yes	1	6	6
87	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
88	L:L:?1	R:R:L83	6.42	Yes	Yes	1	0	6
89	R:R:D85	R:R:F95	4.78	No	No	0	4	7
90	R:R:N86	R:R:W91	6.78	No	Yes	0	5	4
91	R:R:N86	R:R:W93	9.04	No	Yes	0	5	9
92	R:R:W91	R:R:Y87	8.68	Yes	Yes	0	4	6
93	L:L:?1	R:R:Y87	4.35	Yes	Yes	1	0	6
94	R:R:D92	R:R:R89	4.76	No	No	0	4	4
95	R:R:S178	R:R:W91	3.71	No	Yes	0	4	4
96	R:R:F277	R:R:W91	6.01	No	Yes	0	5	4
97	R:R:D92	R:R:K94	6.91	No	No	0	4	3
98	R:R:F95	R:R:W93	22.05	No	Yes	0	7	9
99	R:R:P99	R:R:W93	8.11	No	Yes	0	5	9
100	R:R:C100	R:R:W93	9.14	Yes	Yes	1	9	9
101	R:R:M103	R:R:W93	12.8	Yes	Yes	1	5	9
102	R:R:C177	R:R:W93	19.59	No	Yes	1	9	9
103	R:R:G96	R:R:P99	4.06	No	No	0	7	5
104	R:R:D97	R:R:P168	12.88	No	No	0	3	4
105	R:R:I98	R:R:P99	3.39	No	No	0	2	5
106	R:R:C100	R:R:M167	3.24	Yes	Yes	0	9	3
107	R:R:C100	R:R:P168	11.3	Yes	No	0	9	4
108	R:R:C100	R:R:C177	5.46	Yes	No	1	9	9
109	R:R:L107	R:R:M103	4.24	Yes	Yes	1	6	5
110	R:R:C177	R:R:M103	3.24	No	Yes	1	9	5
111	R:R:L104	R:R:M167	4.24	No	Yes	0	5	3
112	R:R:L104	R:R:S179	6.01	No	No	0	5	4
113	R:R:F105	R:R:M109	9.95	No	Yes	0	6	5
114	R:R:F105	R:R:T159	5.19	No	No	0	6	7
115	R:R:F105	R:R:L163	12.18	No	No	0	6	5
116	R:R:L107	R:R:Y284	5.86	Yes	Yes	1	6	7
117	L:L:?1	R:R:L107	10.27	Yes	Yes	1	0	6
118	R:R:M109	R:R:N110	4.21	Yes	No	0	5	9
119	R:R:M109	R:R:W152	3.49	Yes	Yes	0	5	9
120	R:R:I156	R:R:M109	4.37	No	Yes	0	4	5
121	R:R:F180	R:R:R111	3.21	Yes	Yes	1	3	8
122	R:R:E196	R:R:R111	4.65	Yes	Yes	0	5	8
123	R:R:R111	R:R:T283	6.47	Yes	No	0	8	8
124	R:R:R111	R:R:Y284	4.12	Yes	Yes	1	8	7
125	L:L:?1	R:R:R111	13.52	Yes	Yes	1	0	8
126	R:R:L158	R:R:Q112	5.32	No	No	0	5	7
127	R:R:M192	R:R:Q112	6.8	No	No	0	5	7
128	R:R:E196	R:R:Q112	10.19	Yes	No	0	5	7
129	R:R:G113	R:R:T155	3.64	No	No	0	7	7
130	R:R:E196	R:R:I115	4.1	Yes	No	0	5	8
131	R:R:I115	R:R:P200	3.39	No	No	0	8	9
132	R:R:F244	R:R:I115	8.79	No	No	0	8	8
133	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
134	R:R:I116	R:R:T155	4.56	No	No	0	5	7
135	R:R:F117	R:R:L151	4.87	Yes	Yes	0	8	7
136	R:R:F117	R:R:W152	10.02	Yes	Yes	2	8	9
137	R:R:L118	R:R:N286	4.12	Yes	No	2	9	9
138	R:R:D290	R:R:L118	4.07	Yes	Yes	2	9	9
139	R:R:L118	R:R:Y294	9.38	Yes	Yes	2	9	9
140	R:R:P200	R:R:T119	6.99	No	No	0	9	7
141	R:R:I203	R:R:T119	6.08	No	No	0	7	7
142	R:R:I204	R:R:T119	3.04	No	No	0	8	7
143	R:R:L151	R:R:V120	4.47	Yes	No	0	7	7
144	R:R:V121	R:R:Y294	3.79	No	Yes	0	9	9
145	R:R:D124	R:R:R128	11.91	No	No	5	8	8
146	R:R:R125	R:R:Y294	8.23	No	Yes	0	9	9
147	R:R:V130	R:R:Y126	10.09	No	Yes	0	8	7
148	R:R:F206	R:R:Y126	3.09	No	Yes	6	4	7
149	R:R:C207	R:R:Y126	6.72	No	Yes	0	8	7
150	R:R:R210	R:R:Y126	7.2	No	Yes	6	4	7
151	R:R:F127	R:R:H134	11.31	No	No	0	5	4
152	R:R:I211	R:R:V129	10.75	No	No	0	8	8
153	R:R:L215	R:R:V129	4.47	No	No	0	8	8
154	R:R:H131	R:R:V130	4.15	No	No	0	7	8
155	R:R:S214	R:R:V130	4.85	No	No	0	5	8
156	R:R:H133	R:R:P132	6.1	No	No	0	6	8
157	R:R:P132	R:R:R218	4.32	No	No	0	8	5
158	R:R:I139	R:R:T143	6.08	No	No	0	7	3
159	R:R:S140	R:R:T143	6.4	No	No	0	6	3
160	R:R:G153	R:R:I156	3.53	No	No	0	4	4
161	R:R:L158	R:R:W188	3.42	No	No	0	5	5
162	R:R:L163	R:R:V160	4.47	No	No	0	5	4
163	R:R:K164	R:R:V160	3.04	No	No	0	4	4
164	R:R:H161	R:R:L162	9	No	No	1	7	4
165	R:R:H161	R:R:W188	3.17	No	No	0	7	5
166	R:R:H161	R:R:H189	3.58	No	Yes	1	7	5
167	R:R:H189	R:R:L162	3.86	Yes	No	1	5	4
168	R:R:K165	R:R:M167	7.2	No	Yes	0	4	3
169	R:R:N175	R:R:Q170	10.56	No	No	0	4	1
170	R:R:L176	R:R:N171	4.12	No	No	0	4	1
171	R:R:L176	R:R:S178	4.5	No	No	0	4	4
172	R:R:H189	R:R:S179	8.37	Yes	No	0	5	4
173	L:L:?1	R:R:S179	8.35	Yes	No	0	0	4
174	R:R:F180	R:R:H189	9.05	Yes	Yes	1	3	5
175	R:R:F180	R:R:F193	16.08	Yes	No	0	3	6
176	R:R:F180	R:R:R251	5.34	Yes	No	1	3	5
177	R:R:F180	R:R:F276	3.22	Yes	Yes	1	3	4
178	R:R:F180	R:R:L280	7.31	Yes	No	1	3	5
179	L:L:?1	R:R:F180	6.77	Yes	Yes	1	0	3
180	R:R:I182	R:R:I254	5.89	No	No	0	3	4
181	R:R:H184	R:R:T263	4.11	No	No	3	3	3
182	R:R:F186	R:R:F255	5.36	No	No	0	4	5
183	R:R:M192	R:R:W188	10.47	No	No	0	5	5
184	R:R:H189	R:R:M192	3.94	Yes	No	0	5	5
185	R:R:E190	R:R:R251	11.63	No	No	0	4	5
186	R:R:E190	R:R:F255	13.99	No	No	0	4	5
187	R:R:E196	R:R:F193	4.66	Yes	No	0	5	6
188	R:R:F193	R:R:S247	5.28	No	Yes	0	6	6
189	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
190	R:R:F197	R:R:L201	7.31	Yes	No	0	8	7
191	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
192	R:R:F197	R:R:V248	15.73	Yes	No	0	8	8
193	R:R:F240	R:R:L201	3.65	No	No	0	9	7
194	R:R:F240	R:R:I204	6.28	No	No	0	9	8
195	R:R:F206	R:R:R210	8.55	No	No	6	4	4
196	R:R:I233	R:R:S208	3.1	No	No	0	7	8
197	R:R:R210	R:R:W213	7	No	No	0	4	3
198	R:R:I212	R:R:R216	6.26	No	No	0	5	4
199	R:R:I212	R:R:I230	5.89	No	No	0	5	6
200	R:R:I230	R:R:L215	4.28	No	No	0	6	8
201	R:R:M220	R:R:R218	3.72	No	No	0	3	5
202	R:R:H223	R:R:I226	5.3	No	No	0	4	6
203	R:R:F232	R:R:R228	3.21	Yes	No	0	7	7
204	R:R:P299	R:R:R228	4.32	No	No	0	5	7
205	R:R:F232	R:R:V235	3.93	Yes	No	0	7	5
206	R:R:F232	R:R:V293	5.24	Yes	No	0	7	8
207	R:R:F232	R:R:S297	13.21	Yes	No	0	7	6
208	R:R:V236	R:R:V293	3.21	No	No	0	8	8
209	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
210	R:R:F240	R:R:F244	13.93	No	No	0	9	8
211	R:R:F244	R:R:T283	7.78	No	No	0	8	8
212	R:R:P246	R:R:T279	3.5	No	Yes	0	9	7
213	R:R:F276	R:R:S247	6.61	Yes	Yes	1	4	6
214	R:R:S247	R:R:T279	4.8	Yes	Yes	1	6	7
215	R:R:L280	R:R:S247	3	No	Yes	1	5	6
216	R:R:I252	R:R:V248	3.07	No	No	0	6	8
217	R:R:F276	R:R:V250	6.55	Yes	No	1	4	5
218	R:R:T279	R:R:V250	3.17	Yes	No	1	7	5
219	R:R:F276	R:R:R251	12.83	Yes	No	1	4	5
220	R:R:I254	R:R:Y269	4.84	No	Yes	0	4	2
221	R:R:I254	R:R:V272	4.61	No	No	0	4	4
222	R:R:L257	R:R:W256	4.56	No	No	0	3	4
223	R:R:T260	R:R:W256	6.06	No	No	0	1	4
224	R:R:L258	R:R:Y269	3.52	No	Yes	0	3	2
225	R:R:S261	R:R:T260	4.8	No	No	0	3	1
226	R:R:E267	R:R:N265	5.26	No	No	0	2	5
227	R:R:N265	R:R:V268	7.39	No	No	0	5	1
228	R:R:C266	R:R:E267	6.08	Yes	No	0	7	2
229	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
230	R:R:D273	R:R:F277	5.97	No	No	0	4	5
231	R:R:F276	R:R:F277	6.43	Yes	No	0	4	5
232	R:R:F276	R:R:T279	3.89	Yes	Yes	1	4	7
233	L:L:?1	R:R:L280	11.55	Yes	No	1	0	5
234	R:R:S281	R:R:Y284	3.82	No	Yes	0	6	7
235	L:L:?1	R:R:Y284	9.78	Yes	Yes	1	0	7
236	R:R:D290	R:R:N286	12.12	Yes	No	2	9	9
237	R:R:L289	R:R:M288	4.24	No	Yes	0	7	8
238	R:R:D290	R:R:Y294	5.75	Yes	Yes	2	9	9
239	R:R:P291	R:R:Y295	4.17	Yes	Yes	0	9	7
240	R:R:F296	R:R:P291	4.33	No	Yes	0	8	9
241	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
242	R:R:L289	R:R:V239	2.98	No	No	0	7	7
243	R:R:L245	R:R:V241	2.98	No	No	0	6	5
244	R:R:L245	R:R:V249	2.98	No	No	0	6	6
245	R:R:I211	R:R:I233	2.94	No	No	0	8	7
246	R:R:I238	R:R:I242	2.94	No	No	0	5	5
247	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
248	R:R:E37	R:R:V33	2.85	No	No	0	7	5
249	R:R:I51	R:R:L56	2.85	No	No	0	7	5
250	R:R:I98	R:R:L102	2.85	No	No	0	2	5
251	R:R:I169	R:R:L176	2.85	No	No	0	1	4
252	R:R:L215	R:R:M220	2.83	No	No	0	8	3
253	R:R:C266	R:R:F21	2.79	Yes	No	0	7	2
254	R:R:A191	R:R:F186	2.77	No	No	0	3	4
255	R:R:K16	R:R:Q187	2.71	Yes	No	0	4	2
256	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
257	R:R:H223	R:R:M220	2.63	No	No	0	4	3
258	R:R:F65	R:R:V120	2.62	No	No	0	7	7
259	R:R:F127	R:R:V123	2.62	No	No	0	5	6
260	R:R:F10	R:R:T263	2.59	Yes	No	3	7	3
261	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
262	R:R:H134	R:R:L136	2.57	No	No	0	4	4
263	R:R:H134	R:R:N137	2.55	No	No	0	4	4
264	R:R:F65	R:R:I147	2.51	No	No	0	7	5
265	R:R:F282	R:R:M285	2.49	No	No	0	7	5
266	R:R:M167	R:R:R101	2.48	Yes	No	0	3	6
267	R:R:L257	R:R:R253	2.43	No	No	0	3	5
268	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
269	R:R:N137	R:R:R128	2.41	No	No	0	4	8
270	R:R:D221	R:R:R216	2.38	No	No	0	3	4
271	R:R:F82	R:R:F95	2.14	No	No	0	6	7
272	R:R:G172	R:R:G173	2.11	No	No	7	3	4
273	R:R:F127	R:R:Y126	2.06	No	Yes	0	5	7
274	R:R:G44	R:R:P291	2.03	No	Yes	0	7	9
275	R:R:R22	R:R:W91	2	Yes	Yes	0	3	4
276	R:R:G262	R:R:S261	1.86	No	No	0	4	3
277	R:R:G157	R:R:V160	1.84	No	No	0	5	4
278	R:R:A122	R:R:C207	1.81	No	No	0	9	8
279	R:R:P299	R:R:S298	1.78	No	No	0	5	8
280	R:R:G41	R:R:M288	1.75	No	Yes	0	8	8
281	R:R:G44	R:R:L43	1.71	No	No	0	7	4
282	R:R:A145	R:R:S148	1.71	No	No	0	3	8
283	R:R:G202	R:R:L201	1.71	No	No	0	3	7
284	R:R:A237	R:R:S208	1.71	No	No	0	7	8
285	R:R:C243	R:R:V239	1.71	No	No	0	8	7
286	R:R:G262	R:R:L258	1.71	No	No	0	4	3
287	R:R:A108	R:R:T159	1.68	No	No	0	4	7
288	R:R:K225	R:R:P299	1.67	No	No	0	5	5
289	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
290	R:R:L80	R:R:P81	1.64	No	No	0	8	8
291	R:R:G172	R:R:Q170	1.64	No	No	7	3	1
292	R:R:G173	R:R:Q170	1.64	No	No	7	4	1
293	R:R:L199	R:R:P200	1.64	No	No	0	4	9
294	R:R:C207	R:R:I203	1.64	No	No	0	8	7
295	R:R:G262	R:R:Q264	1.64	No	No	0	4	3
296	R:R:V29	R:R:V33	1.6	No	No	0	5	5
297	R:R:V292	R:R:V293	1.6	No	No	0	6	8
298	R:R:A191	R:R:L195	1.58	No	No	0	3	4
299	R:R:I182	R:R:V20	1.54	No	No	0	3	2
300	R:R:L194	R:R:V248	1.49	No	No	0	4	8
301	R:R:I13	R:R:I169	1.47	Yes	No	0	3	1
302	R:R:I154	R:R:L150	1.43	No	No	0	5	4
303	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
304	R:R:I154	R:R:L158	1.43	No	No	0	5	5
305	R:R:C19	R:R:F10	1.4	No	Yes	3	4	7
306	R:R:C266	R:R:F10	1.4	Yes	Yes	3	7	7
307	R:R:D14	R:R:I13	1.4	No	Yes	0	5	3
308	R:R:R142	R:R:S140	1.32	No	No	0	4	6
309	R:R:E12	R:R:N17	1.31	No	No	0	5	5
310	R:R:D221	R:R:Q219	1.31	No	No	0	3	3
311	R:R:F232	R:R:T231	1.3	Yes	No	0	7	6
312	R:R:I146	R:R:R142	1.25	No	No	0	3	4
313	R:R:F296	R:R:L47	1.22	No	No	0	8	6
314	R:R:Q219	R:R:R222	1.17	No	No	0	3	3
315	R:R:F10	R:R:H9	1.13	Yes	No	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F10	1.63	4	3	7
2	R:R:I13	4.125	4	0	3
3	R:R:K16	5.1675	4	0	4
4	R:R:R22	5.6275	4	0	3
5	R:R:L30	3.1275	4	0	5
6	R:R:L69	4.164	5	2	9
7	R:R:D73	5.625	4	2	9
8	R:R:F74	4.31	4	4	7
9	R:R:I77	3.786	5	4	6
10	R:R:L83	6.336	5	1	6
11	R:R:Y87	6.775	4	1	6
12	R:R:W91	5.436	5	0	4
13	R:R:W93	13.455	6	1	9
14	R:R:C100	7.285	4	1	9
15	R:R:M103	5.834	5	1	5
16	R:R:L107	6.134	5	1	6
17	R:R:M109	5.505	4	0	5
18	R:R:R111	6.394	5	1	8
19	R:R:F117	8.26	4	2	8
20	R:R:L118	5.43	4	2	9
21	R:R:Y126	5.26333	6	6	7
22	R:R:L151	4.12	4	0	7
23	R:R:W152	5.72	4	2	9
24	R:R:M167	4.29	4	0	3
25	R:R:F180	7.28286	7	1	3
26	R:R:H189	5.76	5	1	5
27	R:R:E196	5.9	4	0	5
28	R:R:F197	8.89	4	0	8
29	R:R:F232	5.378	5	0	7
30	R:R:S247	4.9225	4	1	6
31	R:R:C266	3.4775	4	3	7
32	R:R:Y269	4.045	4	0	2
33	R:R:F276	6.58833	6	1	4
34	R:R:T279	3.84	4	1	7
35	R:R:Y284	5.42	5	1	7
36	R:R:M288	4.3775	4	0	8
37	R:R:D290	6.804	5	2	9
38	R:R:P291	3.4475	4	0	9
39	R:R:Y294	6.03	7	2	9
40	R:R:Y295	4.88714	7	2	7
41	L:L:?1	8.87625	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I13	R:R:I169	10.9632	1.47	Yes	No	0	3	1
2	R:R:I169	R:R:L176	12.1757	2.85	No	No	0	1	4
3	R:R:C266	R:R:F10	14.0896	1.4	Yes	Yes	3	7	7
4	R:R:C266	R:R:F21	60.1605	2.79	Yes	No	0	7	2
5	R:R:D273	R:R:F21	71.0477	8.36	No	No	0	4	2
6	R:R:D273	R:R:F277	72.9869	5.97	No	No	0	4	5
7	R:R:F277	R:R:W91	22.2349	6.01	No	Yes	0	5	4
8	R:R:S178	R:R:W91	16.7554	3.71	No	Yes	0	4	4
9	R:R:L176	R:R:S178	15.7499	4.5	No	No	0	4	4
10	R:R:C19	R:R:C266	36.9328	3.64	No	Yes	3	4	7
11	R:R:C19	R:R:Y269	35.0148	4.03	No	Yes	0	4	2
12	R:R:I254	R:R:Y269	11.7237	4.84	No	Yes	0	4	2
13	R:R:R22	R:R:W91	10.0338	2	Yes	Yes	0	3	4
14	R:R:W91	R:R:Y87	35.2471	8.68	Yes	Yes	0	4	6
15	R:R:L30	R:R:Y87	23.8276	3.52	Yes	Yes	0	5	6
16	R:R:L30	R:R:S281	23.2108	4.5	Yes	No	0	5	6
17	R:R:L34	R:R:S281	52.5982	4.5	No	No	0	8	6
18	R:R:L34	R:R:L80	51.2421	5.54	No	No	0	8	8
19	R:R:G41	R:R:M288	13.2193	1.75	No	Yes	0	8	8
20	R:R:G41	R:R:I77	14.4951	3.53	No	Yes	0	8	6
21	R:R:I77	R:R:L80	48.8973	4.28	Yes	No	0	6	8
22	R:R:I77	R:R:N45	22.4292	4.25	Yes	No	4	6	9
23	R:R:N45	R:R:P291	22.4461	3.26	No	Yes	0	9	9
24	R:R:F52	R:R:Y295	16.2738	5.16	No	Yes	0	7	7
25	R:R:P291	R:R:Y295	20.5027	4.17	Yes	Yes	0	9	7
26	R:R:F52	R:R:F67	15.0401	4.29	No	No	0	7	6
27	R:R:F67	R:R:W59	12.1926	6.01	No	No	0	6	6
28	R:R:F65	R:R:V120	20.583	2.62	No	No	0	7	7
29	R:R:L151	R:R:V120	22.6362	4.47	Yes	No	0	7	7
30	R:R:I154	R:R:L151	97.3891	1.43	No	Yes	0	5	7
31	R:R:I154	R:R:L158	100	1.43	No	No	0	5	5
32	R:R:L158	R:R:Q112	76.3371	5.32	No	No	0	5	7
33	R:R:E196	R:R:Q112	66.1639	10.19	Yes	No	0	5	7
34	R:R:E196	R:R:R111	56.5737	4.65	Yes	Yes	0	5	8
35	L:L:?1	R:R:R111	26.1132	13.52	Yes	Yes	1	0	8
36	L:L:?1	R:R:Y87	15.264	4.35	Yes	Yes	1	0	6
37	R:R:F65	R:R:S61	16.2188	5.28	No	No	0	7	6
38	R:R:I139	R:R:S61	11.5294	3.1	No	No	0	7	6
39	R:R:F127	R:R:H134	11.1196	11.31	No	No	0	5	4
40	R:R:F127	R:R:Y126	14.8416	2.06	No	Yes	0	5	7
41	R:R:C207	R:R:Y126	58.0735	6.72	No	Yes	0	8	7
42	R:R:C207	R:R:I203	61.335	1.64	No	No	0	8	7
43	R:R:I203	R:R:T119	62.9531	6.08	No	No	0	7	7
44	R:R:P200	R:R:T119	62.9404	6.99	No	No	0	9	7
45	R:R:I115	R:R:P200	66.0076	3.39	No	No	0	8	9
46	R:R:E196	R:R:I115	73.0841	4.1	Yes	No	0	5	8
47	R:R:Y294	R:R:Y295	19.8817	3.97	Yes	Yes	2	9	7
48	R:R:I77	R:R:S287	17.5877	3.1	Yes	No	0	6	8
49	R:R:D73	R:R:S287	16.9582	5.89	Yes	No	0	9	8
50	R:R:D290	R:R:D73	10.5154	6.65	Yes	Yes	2	9	9
51	R:R:D290	R:R:Y294	18.8255	5.75	Yes	Yes	2	9	9
52	R:R:F117	R:R:L151	79.3071	4.87	Yes	Yes	0	8	7
53	R:R:F117	R:R:W152	34.4698	10.02	Yes	Yes	2	8	9
54	R:R:L118	R:R:L69	12.8095	4.15	Yes	Yes	2	9	9
55	R:R:M109	R:R:W152	30.1479	3.49	Yes	Yes	0	5	9
56	R:R:L83	R:R:M103	18.5678	5.65	Yes	Yes	1	6	5
57	R:R:M103	R:R:W93	25.9442	12.8	Yes	Yes	1	5	9
58	R:R:L83	R:R:Y284	11.673	3.52	Yes	Yes	1	6	7
59	R:R:P99	R:R:W93	11.6223	8.11	No	Yes	0	5	9
60	R:R:L104	R:R:S179	11.2505	6.01	No	No	0	5	4
61	R:R:F105	R:R:M109	16.409	9.95	No	Yes	0	6	5
62	R:R:F180	R:R:F276	50.583	3.22	Yes	Yes	1	3	4
63	R:R:F276	R:R:F277	58.0059	6.43	Yes	No	0	4	5
64	R:R:R111	R:R:T283	12.5433	6.47	Yes	No	0	8	8
65	R:R:H189	R:R:S179	10.4563	8.37	Yes	No	0	5	4
66	R:R:H189	R:R:M192	26.4385	3.94	Yes	No	0	5	5
67	R:R:F180	R:R:H189	32.5982	9.05	Yes	Yes	1	3	5
68	R:R:F244	R:R:T283	11.4153	7.78	No	No	0	8	8
69	R:R:F240	R:R:F244	16.2695	13.93	No	No	0	9	8
70	R:R:I211	R:R:Y126	32.725	2.42	No	Yes	0	8	7
71	R:R:I211	R:R:V129	25.7921	10.75	No	No	0	8	8
72	R:R:L215	R:R:V129	23.9882	4.47	No	No	0	8	8
73	R:R:L215	R:R:M220	11.3435	2.83	No	No	0	8	3
74	R:R:H161	R:R:H189	14.4191	3.58	No	Yes	1	7	5
75	R:R:H161	R:R:W188	14.06	3.17	No	No	0	7	5
76	R:R:M192	R:R:W188	13.6629	10.47	No	No	0	5	5
77	R:R:F180	R:R:F193	17.8285	16.08	Yes	No	0	3	6
78	R:R:F193	R:R:S247	15.4668	5.28	No	Yes	0	6	6
79	R:R:F276	R:R:S247	12.9911	6.61	Yes	Yes	1	4	6
80	R:R:F186	R:R:F255	10.7562	5.36	No	No	0	4	5
81	R:R:E190	R:R:F255	14.4867	13.99	No	No	0	4	5
82	R:R:E190	R:R:R251	18.0439	11.63	No	No	0	4	5
83	R:R:F197	R:R:L201	12.0955	7.31	Yes	No	0	8	7
84	R:R:F240	R:R:L201	15.0359	3.65	No	No	0	9	7
85	R:R:I230	R:R:L215	11.1238	4.28	No	No	0	6	8
86	R:R:F232	R:R:V293	28.0144	5.24	Yes	No	0	7	8
87	R:R:V236	R:R:V293	35.0739	3.21	No	No	0	8	8
88	R:R:V236	R:R:Y294	38.3523	7.57	No	Yes	0	8	9
89	R:R:F232	R:R:R228	13.8065	3.21	Yes	No	0	7	7
90	R:R:P299	R:R:R228	10.2281	4.32	No	No	0	5	7
91	R:R:L258	R:R:Y269	19.079	3.52	No	Yes	0	3	2
92	R:R:G262	R:R:L258	16.9117	1.71	No	No	0	4	3
93	R:R:G262	R:R:S261	12.1208	1.86	No	No	0	4	3
94	R:R:M192	R:R:Q112	13.7896	6.8	No	No	0	5	7
95	R:R:L158	R:R:W188	25.8724	3.42	No	No	0	5	5
96	R:R:F180	R:R:R111	23.8868	3.21	Yes	Yes	1	3	8
97	R:R:E196	R:R:F193	32.9066	4.66	Yes	No	0	5	6
98	R:R:F117	R:R:L69	52.4166	3.65	Yes	Yes	2	8	9
99	R:R:R111	R:R:Y284	26.4343	4.12	Yes	Yes	1	8	7
100	R:R:S281	R:R:Y284	33.1686	3.82	No	Yes	0	6	7
101	R:R:L107	R:R:Y284	13.0292	5.86	Yes	Yes	1	6	7
102	R:R:F180	R:R:R251	19.5184	5.34	Yes	No	1	3	5
103	R:R:L107	R:R:M103	17.4102	4.24	Yes	Yes	1	6	5
104	R:R:L69	R:R:Y295	23.4305	3.52	Yes	Yes	2	9	7
105	R:R:L118	R:R:Y294	10.0211	9.38	Yes	Yes	2	9	9
106	R:R:D290	R:R:L69	11.4575	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L30	R:R:Y87	3.52	0	Yes	Yes	5	6	2	1
R:R:L30	R:R:S281	4.5	0	Yes	No	5	6	2	2
R:R:C79	R:R:M103	3.24	1	No	Yes	6	5	2	2
R:R:C79	R:R:L107	4.76	1	No	Yes	6	6	2	1
R:R:L83	R:R:Y87	10.55	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:M103	5.65	1	Yes	Yes	6	5	1	2
R:R:L107	R:R:L83	5.54	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L83	6.42	1	Yes	Yes	0	6	0	1
R:R:W91	R:R:Y87	8.68	0	Yes	Yes	4	6	2	1
L:L:?1	R:R:Y87	4.35	1	Yes	Yes	0	6	0	1
R:R:L107	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L104	R:R:S179	6.01	0	No	No	5	4	2	1
R:R:L107	R:R:Y284	5.86	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	10.27	1	Yes	Yes	0	6	0	1
R:R:F180	R:R:R111	3.21	1	Yes	Yes	3	8	1	1
R:R:E196	R:R:R111	4.65	0	Yes	Yes	5	8	2	1
R:R:R111	R:R:T283	6.47	1	Yes	No	8	8	1	2
R:R:R111	R:R:Y284	4.12	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:R111	13.52	1	Yes	Yes	0	8	0	1
R:R:H189	R:R:S179	8.37	1	Yes	No	5	4	2	1
L:L:?1	R:R:S179	8.35	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	16.08	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	5.34	1	Yes	No	3	5	1	2
R:R:F180	R:R:F276	3.22	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	7.31	1	Yes	No	3	5	1	1
L:L:?1	R:R:F180	6.77	1	Yes	Yes	0	3	0	1
R:R:E196	R:R:F193	4.66	0	Yes	No	5	6	2	2
R:R:F193	R:R:S247	5.28	0	No	Yes	6	6	2	2
R:R:F276	R:R:S247	6.61	1	Yes	Yes	4	6	2	2
R:R:L280	R:R:S247	3	1	No	Yes	5	6	1	2
R:R:F276	R:R:R251	12.83	1	Yes	No	4	5	2	2
L:L:?1	R:R:L280	11.55	1	Yes	No	0	5	0	1
R:R:S281	R:R:Y284	3.82	0	No	Yes	6	7	2	1
L:L:?1	R:R:Y284	9.78	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H2G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	274
Number of Links	315
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	7
Number of Nodes involved in Communities	50
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	107
Number Of Links MetaPath	106
Number of Shortest Paths	65783
Length Of Smallest Path	3
Average Path Length	14.1736
Length of Longest Path	32
Minimum Path Strength	1.24
Average Path Strength	5.35185
Maximum Path Strength	20.82
Minimum Path Correlation	0.7
Average Path Correlation	0.92122
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.8694
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3208
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • periplasmic space • cell junction • cell periphery • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	3-carboxypyridine
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8H2G_nogp_Chain_R H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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