psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	7.7	Yes	Yes	1	0	6
2	L:L:?1	R:R:Y87	3.26	Yes	Yes	1	0	6
3	L:L:?1	R:R:L107	10.27	Yes	No	0	0	6
4	L:L:?1	R:R:R111	7.88	Yes	Yes	1	0	8
5	L:L:?1	R:R:S178	5.57	Yes	No	0	0	4
6	L:L:?1	R:R:F180	15.81	Yes	Yes	1	0	3
7	L:L:?1	R:R:Y284	7.61	Yes	Yes	1	0	7
8	R:R:F10	R:R:F21	6.43	No	No	0	7	2
9	R:R:D14	R:R:E12	6.5	No	No	0	5	5
10	R:R:E12	R:R:V20	5.7	No	No	2	5	2
11	R:R:E12	R:R:N171	7.89	No	Yes	2	5	1
12	R:R:D14	R:R:I169	12.59	No	No	0	5	1
13	R:R:C18	R:R:K16	3.23	No	Yes	0	9	4
14	R:R:K16	R:R:T185	13.51	Yes	No	0	4	2
15	R:R:K16	R:R:Q187	4.07	Yes	No	0	4	2
16	R:R:C18	R:R:C183	7.28	No	No	0	9	1
17	R:R:C19	R:R:C266	7.28	No	No	0	4	7
18	R:R:N171	R:R:V20	4.43	Yes	No	2	1	2
19	R:R:L176	R:R:V20	4.47	No	No	2	4	2
20	R:R:F21	R:R:R270	3.21	No	No	0	2	1
21	R:R:R22	R:R:R90	6.4	No	No	0	3	4
22	R:R:A174	R:R:R22	4.15	No	No	0	2	3
23	R:R:D23	R:R:F25	3.58	No	No	0	4	6
24	R:R:D23	R:R:R270	11.91	No	No	0	4	1
25	R:R:D23	R:R:L274	4.07	No	No	0	4	1
26	R:R:D24	R:R:K28	4.15	No	No	0	4	3
27	R:R:D24	R:R:R90	4.76	No	No	0	4	4
28	R:R:F25	R:R:K28	3.72	No	No	0	6	3
29	R:R:I26	R:R:L30	7.14	No	Yes	1	5	5
30	R:R:I26	R:R:Y87	3.63	No	Yes	1	5	6
31	R:R:I26	R:R:L274	2.85	No	No	0	5	1
32	R:R:L30	R:R:Y87	3.52	Yes	Yes	1	5	6
33	R:R:I278	R:R:L30	2.85	No	Yes	0	6	5
34	R:R:P31	R:R:P32	7.79	No	No	0	6	5
35	R:R:M84	R:R:P31	3.35	No	No	0	7	6
36	R:R:E37	R:R:V33	2.85	No	No	1	7	5
37	R:R:S281	R:R:V33	4.85	No	No	1	6	5
38	R:R:L34	R:R:L80	8.3	No	No	0	8	8
39	R:R:L34	R:R:L83	4.15	No	Yes	0	8	6
40	R:R:E37	R:R:S281	4.31	No	No	1	7	6
41	R:R:E37	R:R:Y284	4.49	No	Yes	1	7	7
42	R:R:F38	R:R:I39	3.77	Yes	No	0	7	5
43	R:R:F38	R:R:I77	5.02	Yes	No	0	7	6
44	R:R:F38	R:R:L80	7.31	Yes	No	0	7	8
45	R:R:F38	R:R:P81	11.56	Yes	No	0	7	8
46	R:R:F40	R:R:M288	7.46	No	No	0	6	8
47	R:R:F74	R:R:L42	4.87	Yes	No	0	7	7
48	R:R:I77	R:R:L42	4.28	No	No	0	6	7
49	R:R:G44	R:R:L43	5.13	No	No	0	7	4
50	R:R:D73	R:R:N45	16.16	Yes	No	0	9	9
51	R:R:F74	R:R:N45	4.83	Yes	No	0	7	9
52	R:R:N45	R:R:P291	4.89	No	No	0	9	9
53	R:R:F74	R:R:G46	4.52	Yes	No	0	7	4
54	R:R:F296	R:R:L47	9.74	No	No	0	8	6
55	R:R:L49	R:R:V71	5.96	No	No	0	7	6
56	R:R:F54	R:R:W50	9.02	No	No	0	4	4
57	R:R:H55	R:R:W50	6.35	No	No	0	5	4
58	R:R:I51	R:R:L56	2.85	No	No	0	7	5
59	R:R:F52	R:R:L66	3.65	No	No	4	7	8
60	R:R:F52	R:R:F67	4.29	No	No	0	7	6
61	R:R:F52	R:R:Y295	5.16	No	Yes	4	7	7
62	R:R:C53	R:R:F54	4.19	No	No	0	4	4
63	R:R:I139	R:R:S61	4.64	No	No	0	7	6
64	R:R:A144	R:R:S61	3.42	No	No	0	7	6
65	R:R:D124	R:R:S62	7.36	No	No	0	8	8
66	R:R:A144	R:R:I64	3.25	No	Yes	0	7	7
67	R:R:F65	R:R:V120	9.18	Yes	No	0	7	7
68	R:R:L66	R:R:V121	2.98	No	No	0	8	9
69	R:R:L66	R:R:Y295	12.89	No	Yes	4	8	7
70	R:R:F67	R:R:N68	4.83	No	Yes	0	6	9
71	R:R:F67	R:R:V71	3.93	No	No	0	6	6
72	R:R:F117	R:R:N68	15.71	Yes	Yes	3	8	9
73	R:R:N68	R:R:S148	8.94	Yes	No	3	9	8
74	R:R:N68	R:R:W152	6.78	Yes	Yes	3	9	9
75	R:R:L69	R:R:S114	3	Yes	No	0	9	9
76	R:R:F117	R:R:L69	3.65	Yes	Yes	0	8	9
77	R:R:D290	R:R:L69	4.07	Yes	Yes	0	9	9
78	R:R:L69	R:R:Y295	3.52	Yes	Yes	0	9	7
79	R:R:V71	R:R:W152	4.9	No	Yes	0	6	9
80	R:R:D73	R:R:S114	2.94	Yes	No	0	9	9
81	R:R:D73	R:R:S287	5.89	Yes	No	0	9	8
82	R:R:D290	R:R:D73	3.99	Yes	Yes	0	9	9
83	R:R:F74	R:R:I78	3.77	Yes	No	0	7	6
84	R:R:L75	R:R:N110	10.98	No	No	0	6	9
85	R:R:L107	R:R:L76	5.54	No	No	0	6	7
86	R:R:L76	R:R:N110	6.87	No	No	0	7	9
87	R:R:L76	R:R:Y284	4.69	No	Yes	0	7	7
88	R:R:C79	R:R:M103	3.24	No	Yes	0	6	5
89	R:R:C79	R:R:L107	7.94	No	No	0	6	6
90	R:R:F82	R:R:M103	4.98	No	Yes	0	6	5
91	R:R:L83	R:R:Y87	8.21	Yes	Yes	1	6	6
92	R:R:L83	R:R:M103	4.24	Yes	Yes	0	6	5
93	R:R:L83	R:R:Y284	3.52	Yes	Yes	1	6	7
94	R:R:N86	R:R:W91	5.65	No	No	0	5	4
95	R:R:N86	R:R:W93	3.39	No	Yes	0	5	9
96	R:R:W91	R:R:Y87	10.61	No	Yes	0	4	6
97	R:R:K94	R:R:R89	9.9	No	No	0	3	4
98	R:R:A174	R:R:D92	6.18	No	No	0	2	4
99	R:R:F95	R:R:W93	11.02	No	Yes	0	7	9
100	R:R:C100	R:R:W93	9.14	No	Yes	5	9	9
101	R:R:M103	R:R:W93	5.82	Yes	Yes	0	5	9
102	R:R:C177	R:R:W93	15.67	No	Yes	5	9	9
103	R:R:F95	R:R:K94	13.65	No	No	0	7	3
104	R:R:F95	R:R:P99	4.33	No	No	0	7	5
105	R:R:D97	R:R:R101	13.1	No	No	0	3	6
106	R:R:D97	R:R:P168	4.83	No	No	0	3	4
107	R:R:I98	R:R:P99	3.39	No	No	0	2	5
108	R:R:I98	R:R:R101	5.01	No	No	0	2	6
109	R:R:C100	R:R:M167	3.24	No	No	0	9	3
110	R:R:C100	R:R:C177	7.28	No	No	5	9	9
111	R:R:L102	R:R:L163	4.15	No	No	0	5	5
112	R:R:C177	R:R:L104	4.76	No	No	0	9	5
113	R:R:F105	R:R:M106	3.73	No	No	0	6	5
114	R:R:F105	R:R:T159	6.49	No	No	0	6	7
115	R:R:I156	R:R:M109	5.83	No	No	0	4	5
116	R:R:M109	R:R:T159	7.53	No	No	0	5	7
117	R:R:E196	R:R:R111	5.82	No	Yes	0	5	8
118	R:R:R111	R:R:T283	6.47	Yes	Yes	1	8	8
119	R:R:R111	R:R:Y284	4.12	Yes	Yes	1	8	7
120	R:R:L158	R:R:Q112	6.65	No	No	0	5	7
121	R:R:M192	R:R:Q112	9.52	No	No	0	5	7
122	R:R:G113	R:R:T155	3.64	No	No	0	7	7
123	R:R:I115	R:R:P200	3.39	No	No	0	8	9
124	R:R:F244	R:R:I115	7.54	Yes	No	0	8	8
125	R:R:I116	R:R:L151	5.71	No	No	0	5	7
126	R:R:F117	R:R:S148	3.96	Yes	No	3	8	8
127	R:R:F117	R:R:L151	9.74	Yes	No	0	8	7
128	R:R:F117	R:R:W152	6.01	Yes	Yes	3	8	9
129	R:R:L118	R:R:Y294	4.69	No	Yes	0	9	9
130	R:R:P200	R:R:T119	3.5	No	No	0	9	7
131	R:R:I203	R:R:T119	4.56	No	No	0	7	7
132	R:R:R125	R:R:V121	6.54	No	No	0	9	9
133	R:R:D124	R:R:R128	10.72	No	No	0	8	8
134	R:R:R125	R:R:Y294	4.12	No	Yes	0	9	9
135	R:R:V130	R:R:Y126	13.88	No	Yes	0	8	7
136	R:R:F206	R:R:Y126	4.13	No	Yes	6	4	7
137	R:R:C207	R:R:Y126	5.38	No	Yes	0	8	7
138	R:R:R210	R:R:Y126	7.2	No	Yes	6	4	7
139	R:R:F127	R:R:H131	3.39	No	No	0	5	7
140	R:R:F127	R:R:H134	3.39	No	Yes	0	5	4
141	R:R:N137	R:R:R128	4.82	No	No	0	4	8
142	R:R:I211	R:R:V129	6.14	No	No	0	8	8
143	R:R:H131	R:R:V130	8.3	No	No	0	7	8
144	R:R:S214	R:R:V130	3.23	No	No	0	5	8
145	R:R:H133	R:R:P132	4.58	No	No	0	6	8
146	R:R:H134	R:R:L136	5.14	Yes	No	0	4	4
147	R:R:H134	R:R:N137	3.83	Yes	No	0	4	4
148	R:R:I139	R:R:T143	4.56	No	No	0	7	3
149	R:R:S140	R:R:T143	4.8	No	No	0	6	3
150	R:R:I146	R:R:R142	3.76	No	No	0	3	4
151	R:R:I154	R:R:L158	4.28	No	No	0	5	5
152	R:R:L158	R:R:W188	5.69	No	No	0	5	5
153	R:R:H161	R:R:L162	12.86	No	No	0	7	4
154	R:R:H161	R:R:W188	4.23	No	No	0	7	5
155	R:R:H161	R:R:H189	3.58	No	No	0	7	5
156	R:R:K165	R:R:M167	4.32	No	No	0	4	3
157	R:R:M167	R:R:P168	5.03	No	No	0	3	4
158	R:R:N175	R:R:Q170	3.96	No	No	0	4	1
159	R:R:L176	R:R:N171	4.12	No	Yes	2	4	1
160	R:R:H189	R:R:S179	9.76	No	No	0	5	4
161	R:R:F180	R:R:H189	6.79	Yes	No	0	3	5
162	R:R:F180	R:R:R251	4.28	Yes	Yes	1	3	5
163	R:R:F180	R:R:F276	4.29	Yes	Yes	1	3	4
164	R:R:F180	R:R:L280	6.09	Yes	Yes	1	3	5
165	R:R:I182	R:R:Y269	4.84	No	No	0	3	2
166	R:R:D273	R:R:I182	11.2	No	No	0	4	3
167	R:R:H184	R:R:T263	8.21	No	No	0	3	3
168	R:R:M192	R:R:W188	11.63	No	No	0	5	5
169	R:R:E190	R:R:R251	12.79	No	Yes	1	4	5
170	R:R:E190	R:R:F255	8.16	No	No	1	4	5
171	R:R:E196	R:R:F193	5.83	No	No	0	5	6
172	R:R:L194	R:R:V248	2.98	No	No	0	4	8
173	R:R:I252	R:R:L194	2.85	No	No	0	6	4
174	R:R:F197	R:R:F240	4.29	Yes	No	1	8	9
175	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
176	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
177	R:R:F197	R:R:V248	6.55	Yes	No	0	8	8
178	R:R:F240	R:R:L201	3.65	No	Yes	0	9	7
179	R:R:F206	R:R:R210	7.48	No	No	6	4	4
180	R:R:I233	R:R:S208	3.1	No	No	0	7	8
181	R:R:R210	R:R:W213	5	No	No	0	4	3
182	R:R:I211	R:R:I233	4.42	No	No	0	8	7
183	R:R:I212	R:R:R216	5.01	Yes	No	0	5	4
184	R:R:I212	R:R:I230	10.3	Yes	No	0	5	6
185	R:R:I212	R:R:I233	2.94	Yes	No	0	5	7
186	R:R:I212	R:R:M234	4.37	Yes	No	0	5	4
187	R:R:Q217	R:R:W213	6.57	No	No	0	5	3
188	R:R:L215	R:R:M220	4.24	No	No	0	8	3
189	R:R:I226	R:R:L215	5.71	No	No	0	6	8
190	R:R:D221	R:R:R216	7.15	No	No	0	3	4
191	R:R:H223	R:R:K225	13.1	No	No	0	4	5
192	R:R:A224	R:R:K225	4.82	No	No	0	3	5
193	R:R:I226	R:R:I230	2.94	No	No	0	6	6
194	R:R:F232	R:R:T231	5.19	No	No	0	7	6
195	R:R:V235	R:R:V293	3.21	No	No	0	5	8
196	R:R:V236	R:R:Y294	7.57	No	Yes	0	8	9
197	R:R:I238	R:R:V241	3.07	No	No	0	5	5
198	R:R:I238	R:R:I242	2.94	No	No	0	5	5
199	R:R:F240	R:R:F244	3.22	No	Yes	1	9	8
200	R:R:C243	R:R:M285	6.48	No	No	0	8	5
201	R:R:C243	R:R:N286	9.45	No	No	0	8	9
202	R:R:F244	R:R:T283	5.19	Yes	Yes	1	8	8
203	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
204	R:R:L245	R:R:P246	3.28	No	No	0	6	9
205	R:R:F282	R:R:P246	7.22	No	No	0	7	9
206	R:R:S247	R:R:T279	6.4	No	No	0	6	7
207	R:R:L280	R:R:S247	3	Yes	No	1	5	6
208	R:R:S247	R:R:T283	3.2	No	Yes	1	6	8
209	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
210	R:R:T279	R:R:V250	6.35	No	No	0	7	5
211	R:R:I254	R:R:R251	3.76	No	Yes	0	4	5
212	R:R:F255	R:R:R251	9.62	No	Yes	1	5	5
213	R:R:F276	R:R:R251	12.83	Yes	Yes	1	4	5
214	R:R:R253	R:R:W256	6	No	No	0	5	4
215	R:R:L257	R:R:R253	6.07	No	No	0	3	5
216	R:R:I254	R:R:V272	3.07	No	No	0	4	4
217	R:R:T260	R:R:W256	8.49	No	No	0	1	4
218	R:R:L258	R:R:T263	2.95	No	No	7	3	3
219	R:R:L258	R:R:Y269	9.38	No	No	7	3	2
220	R:R:T263	R:R:Y269	3.75	No	No	7	3	2
221	R:R:N265	R:R:Q264	3.96	No	No	0	5	3
222	R:R:E267	R:R:N265	3.94	No	No	0	2	5
223	R:R:E267	R:R:R270	9.3	No	No	0	2	1
224	R:R:S271	R:R:V272	3.23	No	No	0	3	4
225	R:R:D273	R:R:F277	8.36	No	No	0	4	5
226	R:R:F276	R:R:F277	7.5	Yes	No	0	4	5
227	R:R:F276	R:R:L280	3.65	Yes	Yes	1	4	5
228	R:R:L280	R:R:T283	2.95	Yes	Yes	1	5	8
229	R:R:M285	R:R:M288	4.33	No	No	0	5	8
230	R:R:L289	R:R:M285	4.24	No	No	0	7	5
231	R:R:D290	R:R:P291	3.22	Yes	No	0	9	9
232	R:R:D290	R:R:Y294	8.05	Yes	Yes	0	9	9
233	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
234	R:R:Y294	R:R:Y295	3.97	Yes	Yes	0	9	7
235	R:R:I13	R:R:N17	2.83	No	No	0	3	5
236	R:R:L75	R:R:M106	2.83	No	No	0	6	5
237	R:R:C266	R:R:F21	2.79	No	No	0	7	2
238	R:R:A144	R:R:F65	2.77	No	Yes	0	7	7
239	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
240	R:R:A70	R:R:Y295	2.67	No	Yes	0	8	7
241	R:R:H223	R:R:I226	2.65	No	No	0	4	6
242	R:R:F65	R:R:S148	2.64	Yes	No	0	7	8
243	R:R:F232	R:R:S297	2.64	No	No	0	7	6
244	R:R:R89	R:R:V88	2.62	No	No	0	4	3
245	R:R:F127	R:R:V123	2.62	No	No	0	5	6
246	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
247	R:R:F65	R:R:I147	2.51	Yes	No	0	7	5
248	R:R:F105	R:R:L163	2.44	No	No	0	6	5
249	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
250	R:R:N171	R:R:R22	2.41	Yes	No	0	1	3
251	R:R:I64	R:R:W59	2.35	Yes	No	0	7	6
252	R:R:Q217	R:R:R218	2.34	No	No	0	5	5
253	R:R:G172	R:R:G173	2.11	No	No	0	3	4
254	R:R:G41	R:R:I77	1.76	No	No	0	8	6
255	R:R:G35	R:R:M84	1.75	No	No	0	5	7
256	R:R:G44	R:R:L47	1.71	No	No	0	7	6
257	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
258	R:R:C243	R:R:V239	1.71	No	No	0	8	7
259	R:R:A108	R:R:T159	1.68	No	No	0	4	7
260	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
261	R:R:L199	R:R:P200	1.64	No	No	0	4	9
262	R:R:C207	R:R:I203	1.64	No	No	0	8	7
263	R:R:N175	R:R:P168	1.63	No	No	0	4	4
264	R:R:A145	R:R:I64	1.62	No	Yes	0	3	7
265	R:R:A122	R:R:I204	1.62	No	No	0	9	8
266	R:R:A237	R:R:I204	1.62	No	No	0	7	8
267	R:R:V29	R:R:V33	1.6	No	No	0	5	5
268	R:R:V249	R:R:V250	1.6	No	No	0	6	5
269	R:R:S261	R:R:T260	1.6	No	No	0	3	1
270	R:R:V292	R:R:V293	1.6	No	No	0	6	8
271	R:R:C266	R:R:L11	1.59	No	No	0	7	8
272	R:R:A237	R:R:L205	1.58	No	No	0	7	4
273	R:R:I156	R:R:V160	1.54	No	No	0	4	4
274	R:R:K60	R:R:S58	1.53	No	No	0	7	6
275	R:R:H131	R:R:P132	1.53	No	No	0	7	8
276	R:R:I116	R:R:T155	1.52	No	No	0	5	7
277	R:R:I154	R:R:T155	1.52	No	No	0	5	7
278	R:R:K164	R:R:V160	1.52	No	No	0	4	4
279	R:R:L56	R:R:S58	1.5	No	No	0	5	6
280	R:R:L176	R:R:S181	1.5	No	No	0	4	4
281	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
282	R:R:L257	R:R:V268	1.49	No	No	0	3	1
283	R:R:L257	R:R:V272	1.49	No	No	0	3	4
284	R:R:D24	R:R:V27	1.46	No	No	0	4	3
285	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
286	R:R:K15	R:R:K16	1.44	No	Yes	0	3	4
287	R:R:F296	R:R:P291	1.44	No	No	0	8	9
288	R:R:I39	R:R:L36	1.43	No	No	0	5	4
289	R:R:I64	R:R:N141	1.42	Yes	No	0	7	2
290	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
291	R:R:D14	R:R:K15	1.38	No	No	0	5	3
292	R:R:R142	R:R:S140	1.32	No	No	0	4	6
293	R:R:F296	R:R:I51	1.26	No	No	0	8	7
294	R:R:F198	R:R:L194	1.22	No	No	0	5	4
295	R:R:L56	R:R:R63	1.21	No	No	0	5	7
296	R:R:D221	R:R:R222	1.19	No	No	0	3	3
297	R:R:I51	R:R:W50	1.17	No	No	0	7	4
298	R:R:K57	R:R:W59	1.16	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.3	7	1	0
2	R:R:K16	5.5625	4	0	4
3	R:R:L30	3.7875	4	1	5
4	R:R:F38	6.915	4	0	7
5	R:R:I64	2.16	4	0	7
6	R:R:F65	4.275	4	0	7
7	R:R:N68	9.065	4	3	9
8	R:R:L69	3.56	4	0	9
9	R:R:D73	7.245	4	0	9
10	R:R:F74	4.4975	4	0	7
11	R:R:L83	5.564	5	1	6
12	R:R:Y87	5.846	5	1	6
13	R:R:W93	9.008	5	5	9
14	R:R:M103	4.57	4	0	5
15	R:R:R111	6.0725	4	1	8
16	R:R:F117	7.814	5	3	8
17	R:R:Y126	6.602	5	6	7
18	R:R:H134	3.455	4	0	4
19	R:R:W152	4.338	5	3	9
20	R:R:N171	4.7125	4	2	1
21	R:R:F180	7.452	5	1	3
22	R:R:F197	5	4	1	8
23	R:R:L201	2.405	4	0	7
24	R:R:I212	5.655	4	0	5
25	R:R:F244	5.74	5	1	8
26	R:R:R251	8.656	5	1	5
27	R:R:F276	6.44	5	1	4
28	R:R:L280	3.9225	4	1	5
29	R:R:T283	4.4525	4	1	8
30	R:R:Y284	4.886	5	1	7
31	R:R:D290	4.8325	4	0	9
32	R:R:Y294	5.365	6	0	9
33	R:R:Y295	5.642	5	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y87	37.1239	3.26	Yes	Yes	1	0	6
2	R:R:I26	R:R:Y87	50.917	3.63	No	Yes	1	5	6
3	R:R:I26	R:R:L274	50.5083	2.85	No	No	0	5	1
4	R:R:D23	R:R:L274	49.0779	4.07	No	No	0	4	1
5	R:R:D23	R:R:R270	15.3359	11.91	No	No	0	4	1
6	R:R:D23	R:R:F25	34.1967	3.58	No	No	0	4	6
7	R:R:F25	R:R:K28	32.6539	3.72	No	No	0	6	3
8	R:R:D24	R:R:K28	31.1009	4.15	No	No	0	4	3
9	R:R:D24	R:R:R90	27.9642	4.76	No	No	0	4	4
10	R:R:R22	R:R:R90	26.3806	6.4	No	No	0	3	4
11	R:R:N171	R:R:R22	21.553	2.41	Yes	No	0	1	3
12	R:R:E12	R:R:N171	15.1571	7.89	No	Yes	2	5	1
13	R:R:D14	R:R:E12	13.6143	6.5	No	No	0	5	5
14	R:R:D14	R:R:K15	10.2324	1.38	No	No	0	5	3
15	L:L:?1	R:R:L83	40.6079	7.7	Yes	Yes	1	0	6
16	R:R:L34	R:R:L83	82.0281	4.15	No	Yes	0	8	6
17	R:R:L34	R:R:L80	81.3946	8.3	No	No	0	8	8
18	R:R:F38	R:R:L80	80.7714	7.31	Yes	No	0	7	8
19	R:R:F38	R:R:I77	78.3193	5.02	Yes	No	0	7	6
20	L:L:?1	R:R:R111	44.2094	7.88	Yes	Yes	1	0	8
21	R:R:R111	R:R:T283	73.5785	6.47	Yes	Yes	1	8	8
22	R:R:F244	R:R:T283	100	5.19	Yes	Yes	1	8	8
23	R:R:F244	R:R:N286	12.5109	8.46	Yes	No	0	8	9
24	R:R:C243	R:R:N286	10.7535	9.45	No	No	0	8	9
25	R:R:I77	R:R:L42	77.083	4.28	No	No	0	6	7
26	R:R:F74	R:R:L42	76.4853	4.87	Yes	No	0	7	7
27	R:R:F74	R:R:N45	74.8148	4.83	Yes	No	0	7	9
28	R:R:N45	R:R:P291	41.3793	4.89	No	No	0	9	9
29	R:R:F296	R:R:P291	22.3959	1.44	No	No	0	8	9
30	R:R:D73	R:R:N45	33.3231	16.16	Yes	No	0	9	9
31	L:L:?1	R:R:F180	39.4636	15.81	Yes	Yes	1	0	3
32	R:R:F180	R:R:H189	44.1941	6.79	Yes	No	0	3	5
33	R:R:H161	R:R:H189	42.7024	3.58	No	No	0	7	5
34	R:R:H161	R:R:W188	41.4304	4.23	No	No	0	7	5
35	R:R:L158	R:R:W188	38.9987	5.69	No	No	0	5	5
36	R:R:I154	R:R:L158	38.1405	4.28	No	No	0	5	5
37	R:R:I154	R:R:T155	37.5121	1.52	No	No	0	5	7
38	R:R:I116	R:R:T155	36.3678	1.52	No	No	0	5	7
39	R:R:I116	R:R:L151	35.8161	5.71	No	No	0	5	7
40	R:R:F117	R:R:L151	35.2746	9.74	Yes	No	0	8	7
41	R:R:F296	R:R:I51	15.6066	1.26	No	No	0	8	7
42	R:R:L69	R:R:Y295	12.7152	3.52	Yes	Yes	0	9	7
43	R:R:D290	R:R:D73	22.5083	3.99	Yes	Yes	0	9	9
44	R:R:D290	R:R:L69	20.6539	4.07	Yes	Yes	0	9	9
45	R:R:D290	R:R:P291	26.0128	3.22	Yes	No	0	9	9
46	R:R:D290	R:R:Y294	29.3282	8.05	Yes	Yes	0	9	9
47	R:R:F117	R:R:L69	25.5734	3.65	Yes	Yes	0	8	9
48	R:R:F117	R:R:S148	28.8685	3.96	Yes	No	3	8	8
49	R:R:F65	R:R:S148	28.1073	2.64	Yes	No	0	7	8
50	R:R:A144	R:R:F65	22.6769	2.77	No	Yes	0	7	7
51	R:R:A144	R:R:S61	11.5198	3.42	No	No	0	7	6
52	R:R:F244	R:R:I115	67.1928	7.54	Yes	No	0	8	8
53	R:R:I115	R:R:P200	65.7931	3.39	No	No	0	8	9
54	R:R:P200	R:R:T119	62.963	3.5	No	No	0	9	7
55	R:R:I203	R:R:T119	61.5326	4.56	No	No	0	7	7
56	R:R:C207	R:R:I203	60.092	1.64	No	No	0	8	7
57	R:R:C207	R:R:Y126	58.6411	5.38	No	Yes	0	8	7
58	R:R:V130	R:R:Y126	24.2452	13.88	No	Yes	0	8	7
59	R:R:H131	R:R:V130	20.9962	8.3	No	No	0	7	8
60	R:R:F127	R:R:H131	15.8467	3.39	No	No	0	5	7
61	R:R:F127	R:R:H134	12.3627	3.39	No	Yes	0	5	4
62	R:R:L76	R:R:N110	27.5198	6.87	No	No	0	7	9
63	R:R:L75	R:R:N110	25.2822	10.98	No	No	0	6	9
64	R:R:L76	R:R:Y284	21.2976	4.69	No	Yes	0	7	7
65	R:R:L83	R:R:M103	41.8391	4.24	Yes	Yes	0	6	5
66	R:R:M103	R:R:W93	38.4879	5.82	Yes	Yes	0	5	9
67	R:R:F95	R:R:W93	17.4457	11.02	No	Yes	0	7	9
68	R:R:C100	R:R:W93	17.3742	9.14	No	Yes	5	9	9
69	R:R:C100	R:R:M167	14.9885	3.24	No	No	0	9	3
70	R:R:M167	R:R:P168	10.0434	5.03	No	No	0	3	4
71	R:R:L75	R:R:M106	23.0345	2.83	No	No	0	6	5
72	R:R:F105	R:R:M106	20.7765	3.73	No	No	0	6	5
73	R:R:F105	R:R:T159	13.9413	6.49	No	No	0	6	7
74	R:R:I211	R:R:Y126	27.7344	2.42	No	Yes	0	8	7
75	R:R:F180	R:R:F276	11.2388	4.29	Yes	Yes	1	3	4
76	R:R:F276	R:R:F277	10.4879	7.5	Yes	No	0	4	5
77	R:R:F180	R:R:R251	16.8633	4.28	Yes	Yes	1	3	5
78	R:R:F197	R:R:F244	13.8493	4.29	Yes	Yes	1	8	8
79	R:R:F240	R:R:F244	17.3129	3.22	No	Yes	1	9	8
80	R:R:F240	R:R:L201	15.9949	3.65	No	Yes	0	9	7
81	R:R:I211	R:R:I233	24.3883	4.42	No	No	0	8	7
82	R:R:I212	R:R:I233	21.1341	2.94	Yes	No	0	5	7
83	R:R:I212	R:R:I230	12.5109	10.3	Yes	No	0	5	6
84	R:R:I226	R:R:I230	10.7535	2.94	No	No	0	6	6
85	R:R:V293	R:R:Y294	10.5083	3.79	No	Yes	0	8	9
86	R:R:F180	R:R:L280	23.2439	6.09	Yes	Yes	1	3	5
87	R:R:I254	R:R:R251	16.7305	3.76	No	Yes	0	4	5
88	R:R:I254	R:R:V272	14.9119	3.07	No	No	0	4	4
89	R:R:L257	R:R:V272	11.2439	1.49	No	No	0	3	4
90	R:R:L83	R:R:Y284	38.2529	3.52	Yes	Yes	1	6	7
91	R:R:R111	R:R:Y284	32.8123	4.12	Yes	Yes	1	8	7
92	R:R:L83	R:R:Y87	23.2286	8.21	Yes	Yes	1	6	6
93	R:R:L280	R:R:T283	28.7152	2.95	Yes	Yes	1	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	7.7	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y87	3.26	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	10.27	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	7.88	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S178	5.57	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	15.81	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y284	7.61	1	Yes	Yes	0	7	0	1
R:R:I26	R:R:L30	7.14	1	No	Yes	5	5	2	2
R:R:I26	R:R:Y87	3.63	1	No	Yes	5	6	2	1
R:R:L30	R:R:Y87	3.52	1	Yes	Yes	5	6	2	1
R:R:L34	R:R:L83	4.15	0	No	Yes	8	6	2	1
R:R:E37	R:R:Y284	4.49	1	No	Yes	7	7	2	1
R:R:L107	R:R:L76	5.54	0	No	No	6	7	1	2
R:R:L76	R:R:Y284	4.69	0	No	Yes	7	7	2	1
R:R:C79	R:R:M103	3.24	0	No	Yes	6	5	2	2
R:R:C79	R:R:L107	7.94	0	No	No	6	6	2	1
R:R:L83	R:R:Y87	8.21	1	Yes	Yes	6	6	1	1
R:R:L83	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L83	R:R:Y284	3.52	1	Yes	Yes	6	7	1	1
R:R:W91	R:R:Y87	10.61	0	No	Yes	4	6	2	1
R:R:E196	R:R:R111	5.82	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	6.47	1	Yes	Yes	8	8	1	2
R:R:R111	R:R:Y284	4.12	1	Yes	Yes	8	7	1	1
R:R:F180	R:R:H189	6.79	1	Yes	No	3	5	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	4.29	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	6.09	1	Yes	Yes	3	5	1	2
R:R:F276	R:R:R251	12.83	1	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	3.65	1	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	2.95	1	Yes	Yes	5	8	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JIL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	270
Number of Links	298
Number of Hubs	33
Number of Links mediated by Hubs	120
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	51056
Length Of Smallest Path	3
Average Path Length	15.487
Length of Longest Path	36
Minimum Path Strength	1.215
Average Path Strength	5.30846
Maximum Path Strength	13.4467
Minimum Path Correlation	0.7
Average Path Correlation	0.92782
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	46.5721
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.1051
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • regulation of hormone secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • negative regulation of biological process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of cellular process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	3-carboxypyridine
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8JIL_nogp_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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