psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L107	11.55	Yes	No	1	0	6
2	L:L:?1	R:R:R111	10.14	Yes	No	0	0	8
3	L:L:?1	R:R:S178	5.57	Yes	No	0	0	4
4	L:L:?1	R:R:S179	4.18	Yes	No	1	0	4
5	L:L:?1	R:R:F180	11.29	Yes	Yes	1	0	3
6	L:L:?1	R:R:F277	5.65	Yes	Yes	1	0	5
7	L:L:?1	R:R:L280	7.7	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y284	6.52	Yes	Yes	1	0	7
9	R:R:D8	R:R:R22	5.96	No	No	0	6	3
10	R:R:F10	R:R:H9	3.39	Yes	No	0	7	6
11	R:R:E12	R:R:F10	3.5	No	Yes	0	5	7
12	R:R:F10	R:R:N17	13.29	Yes	No	0	7	5
13	R:R:C19	R:R:F10	5.59	No	Yes	0	4	7
14	R:R:I13	R:R:L11	7.14	No	No	0	3	8
15	R:R:C18	R:R:L11	4.76	No	No	0	9	8
16	R:R:D14	R:R:I13	5.6	No	No	0	5	3
17	R:R:I13	R:R:I169	8.83	No	No	0	3	1
18	R:R:D14	R:R:K165	6.91	No	No	0	5	4
19	R:R:K16	R:R:T185	12.01	No	No	0	4	2
20	R:R:N17	R:R:T263	14.62	No	No	0	5	3
21	R:R:C18	R:R:S181	3.44	No	No	0	9	4
22	R:R:C18	R:R:C183	7.28	No	No	0	9	1
23	R:R:C19	R:R:C266	7.28	No	No	0	4	7
24	R:R:V20	R:R:W91	3.68	No	Yes	1	2	4
25	R:R:L176	R:R:V20	5.96	No	No	1	4	2
26	R:R:F21	R:R:R270	14.97	No	No	0	2	1
27	R:R:R22	R:R:R90	12.79	No	No	0	3	4
28	R:R:D24	R:R:F25	4.78	No	No	0	4	6
29	R:R:F25	R:R:L274	3.65	No	No	0	6	1
30	R:R:I26	R:R:L30	5.71	Yes	No	1	5	5
31	R:R:I26	R:R:Y87	3.63	Yes	Yes	1	5	6
32	R:R:I26	R:R:R90	3.76	Yes	No	0	5	4
33	R:R:I26	R:R:W91	3.52	Yes	Yes	1	5	4
34	R:R:R90	R:R:V27	6.54	No	No	0	4	3
35	R:R:L30	R:R:Y87	7.03	No	Yes	1	5	6
36	R:R:P31	R:R:P32	5.84	No	No	0	6	5
37	R:R:P31	R:R:V88	3.53	No	No	0	6	3
38	R:R:E37	R:R:L34	15.9	No	Yes	1	7	8
39	R:R:L34	R:R:L80	4.15	Yes	Yes	1	8	8
40	R:R:L34	R:R:M84	4.24	Yes	No	0	8	7
41	R:R:L34	R:R:Y284	3.52	Yes	Yes	1	8	7
42	R:R:E37	R:R:L80	14.58	No	Yes	1	7	8
43	R:R:E37	R:R:Y284	16.83	No	Yes	1	7	7
44	R:R:F38	R:R:L80	8.53	No	Yes	0	7	8
45	R:R:F38	R:R:P81	5.78	No	No	0	7	8
46	R:R:F40	R:R:M288	4.98	No	No	0	6	8
47	R:R:G41	R:R:I77	5.29	No	No	0	8	6
48	R:R:F74	R:R:L42	4.87	Yes	No	0	7	7
49	R:R:D73	R:R:N45	5.39	Yes	No	2	9	9
50	R:R:F74	R:R:N45	14.5	Yes	No	0	7	9
51	R:R:D290	R:R:N45	5.39	Yes	No	2	9	9
52	R:R:F74	R:R:G46	4.52	Yes	No	0	7	4
53	R:R:L47	R:R:W50	4.56	No	No	0	6	4
54	R:R:A48	R:R:Y294	5.34	No	Yes	0	9	9
55	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
56	R:R:F74	R:R:L49	4.87	Yes	No	0	7	7
57	R:R:H55	R:R:I51	11.93	No	Yes	3	5	7
58	R:R:I51	R:R:L56	4.28	Yes	No	3	7	5
59	R:R:F301	R:R:I51	11.3	Yes	Yes	0	9	7
60	R:R:F304	R:R:I51	8.79	Yes	Yes	3	4	7
61	R:R:F52	R:R:L56	9.74	Yes	No	3	7	5
62	R:R:F52	R:R:R63	6.41	Yes	No	3	7	7
63	R:R:F52	R:R:F67	9.65	Yes	Yes	0	7	6
64	R:R:F304	R:R:H55	21.5	Yes	No	3	4	5
65	R:R:L56	R:R:R63	4.86	No	No	3	5	7
66	R:R:I64	R:R:W59	8.22	No	No	0	7	6
67	R:R:N141	R:R:W59	3.39	No	No	0	2	6
68	R:R:R128	R:R:S61	3.95	Yes	No	0	8	6
69	R:R:I139	R:R:S61	6.19	No	No	0	7	6
70	R:R:R128	R:R:S62	7.91	Yes	No	0	8	8
71	R:R:A144	R:R:I64	4.87	No	No	0	7	7
72	R:R:F65	R:R:V120	9.18	No	No	0	7	7
73	R:R:L66	R:R:V121	4.47	No	No	0	8	9
74	R:R:F67	R:R:N68	3.62	Yes	Yes	0	6	9
75	R:R:F67	R:R:V71	5.24	Yes	No	0	6	6
76	R:R:F117	R:R:N68	13.29	No	Yes	6	8	9
77	R:R:N68	R:R:S148	8.94	Yes	No	0	9	8
78	R:R:N68	R:R:W152	3.39	Yes	Yes	6	9	9
79	R:R:D73	R:R:L69	4.07	Yes	Yes	2	9	9
80	R:R:L118	R:R:L69	4.15	No	Yes	0	9	9
81	R:R:D290	R:R:L69	4.07	Yes	Yes	2	9	9
82	R:R:L69	R:R:V293	4.47	Yes	No	2	9	8
83	R:R:A70	R:R:Y294	4	No	Yes	0	8	9
84	R:R:V71	R:R:W152	3.68	No	Yes	0	6	9
85	R:R:A72	R:R:N110	4.69	No	No	0	8	9
86	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
87	R:R:D73	R:R:S287	10.31	Yes	No	0	9	8
88	R:R:D290	R:R:D73	17.3	Yes	Yes	2	9	9
89	R:R:L76	R:R:N110	13.73	No	No	0	7	9
90	R:R:L76	R:R:Y284	3.52	No	Yes	0	7	7
91	R:R:L76	R:R:S287	9.01	No	No	0	7	8
92	R:R:I77	R:R:L80	5.71	No	Yes	0	6	8
93	R:R:I77	R:R:S287	4.64	No	No	0	6	8
94	R:R:C79	R:R:M106	4.86	No	No	0	6	5
95	R:R:C79	R:R:L107	11.11	No	No	0	6	6
96	R:R:L80	R:R:Y284	3.52	Yes	Yes	1	8	7
97	R:R:L83	R:R:M103	8.48	No	No	0	6	5
98	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
99	R:R:N86	R:R:W93	10.17	No	Yes	0	5	9
100	R:R:W91	R:R:Y87	9.65	Yes	Yes	1	4	6
101	R:R:F277	R:R:Y87	5.16	Yes	Yes	1	5	6
102	R:R:D92	R:R:R89	3.57	No	No	0	4	4
103	R:R:L176	R:R:W91	3.42	No	Yes	1	4	4
104	R:R:F277	R:R:W91	6.01	Yes	Yes	1	5	4
105	R:R:A174	R:R:D92	4.63	No	No	0	2	4
106	R:R:F95	R:R:W93	8.02	No	Yes	0	7	9
107	R:R:P99	R:R:W93	4.05	No	Yes	0	5	9
108	R:R:C100	R:R:W93	6.53	No	Yes	7	9	9
109	R:R:M103	R:R:W93	4.65	No	Yes	0	5	9
110	R:R:N175	R:R:W93	3.39	No	Yes	0	4	9
111	R:R:C177	R:R:W93	18.28	No	Yes	7	9	9
112	R:R:F95	R:R:K94	6.2	No	No	0	7	3
113	R:R:D97	R:R:R101	14.29	No	No	0	3	6
114	R:R:I98	R:R:P99	8.47	No	No	0	2	5
115	R:R:I98	R:R:L102	5.71	No	No	0	2	5
116	R:R:C100	R:R:M167	6.48	No	No	0	9	3
117	R:R:C100	R:R:C177	7.28	No	No	7	9	9
118	R:R:L102	R:R:L163	4.15	No	No	0	5	5
119	R:R:L104	R:R:L162	5.54	No	No	0	5	4
120	R:R:L104	R:R:M167	4.24	No	No	0	5	3
121	R:R:F105	R:R:I156	3.77	No	No	0	6	4
122	R:R:F105	R:R:L163	3.65	No	No	0	6	5
123	R:R:L107	R:R:Y284	3.52	No	Yes	1	6	7
124	R:R:M109	R:R:T155	4.52	No	No	0	5	7
125	R:R:I156	R:R:M109	5.83	No	No	0	4	5
126	R:R:E196	R:R:R111	3.49	No	No	0	5	8
127	R:R:R111	R:R:T283	9.06	No	Yes	0	8	8
128	R:R:I116	R:R:Q112	4.12	No	Yes	0	5	7
129	R:R:Q112	R:R:T155	5.67	Yes	No	0	7	7
130	R:R:M192	R:R:Q112	4.08	No	Yes	0	5	7
131	R:R:E196	R:R:Q112	10.19	No	Yes	0	5	7
132	R:R:G113	R:R:I116	3.53	No	No	0	7	5
133	R:R:G113	R:R:T155	5.46	No	No	0	7	7
134	R:R:E196	R:R:I115	6.83	No	No	0	5	8
135	R:R:I115	R:R:P200	3.39	No	No	0	8	9
136	R:R:F244	R:R:I115	8.79	Yes	No	0	8	8
137	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
138	R:R:F117	R:R:L151	6.09	No	Yes	0	8	7
139	R:R:F117	R:R:W152	13.03	No	Yes	6	8	9
140	R:R:P200	R:R:T119	3.5	No	No	0	9	7
141	R:R:I203	R:R:T119	6.08	No	No	0	7	7
142	R:R:L151	R:R:V120	7.45	Yes	No	0	7	7
143	R:R:R125	R:R:V121	6.54	No	No	0	9	9
144	R:R:C207	R:R:V123	3.42	Yes	No	0	8	6
145	R:R:D124	R:R:R128	11.91	No	Yes	0	8	8
146	R:R:F127	R:R:Y126	12.38	No	Yes	4	5	7
147	R:R:V130	R:R:Y126	12.62	Yes	Yes	4	8	7
148	R:R:H131	R:R:Y126	8.71	Yes	Yes	4	7	7
149	R:R:F206	R:R:Y126	6.19	No	Yes	4	4	7
150	R:R:C207	R:R:Y126	4.03	Yes	Yes	0	8	7
151	R:R:R210	R:R:Y126	6.17	No	Yes	4	4	7
152	R:R:F127	R:R:H131	4.53	No	Yes	4	5	7
153	R:R:F127	R:R:L136	4.87	No	No	0	5	4
154	R:R:N137	R:R:R128	3.62	No	Yes	0	4	8
155	R:R:I211	R:R:V129	4.61	No	No	0	8	8
156	R:R:H131	R:R:V130	11.07	Yes	Yes	4	7	8
157	R:R:R210	R:R:V130	3.92	No	Yes	4	4	8
158	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
159	R:R:I139	R:R:T143	4.56	No	No	0	7	3
160	R:R:S140	R:R:T143	4.8	No	No	0	6	3
161	R:R:I154	R:R:L158	4.28	No	No	0	5	5
162	R:R:G157	R:R:I156	3.53	No	No	0	5	4
163	R:R:G157	R:R:V160	3.68	No	No	0	5	4
164	R:R:L158	R:R:M192	5.65	No	No	0	5	5
165	R:R:M192	R:R:T159	6.02	No	No	0	5	7
166	R:R:H161	R:R:L162	6.43	No	No	0	7	4
167	R:R:N175	R:R:P168	9.77	No	No	0	4	4
168	R:R:F180	R:R:S179	9.25	Yes	No	1	3	4
169	R:R:H189	R:R:S179	6.97	No	No	1	5	4
170	R:R:F180	R:R:H189	9.05	Yes	No	1	3	5
171	R:R:F180	R:R:F193	5.36	Yes	No	0	3	6
172	R:R:F180	R:R:F276	13.93	Yes	Yes	1	3	4
173	R:R:F180	R:R:L280	3.65	Yes	Yes	1	3	5
174	R:R:I182	R:R:Y269	3.63	Yes	Yes	0	3	2
175	R:R:D273	R:R:I182	4.2	No	Yes	0	4	3
176	R:R:E190	R:R:F186	11.66	No	No	1	4	4
177	R:R:F186	R:R:F255	10.72	No	No	1	4	5
178	R:R:E190	R:R:R251	9.3	No	No	1	4	5
179	R:R:E190	R:R:F255	13.99	No	No	1	4	5
180	R:R:F193	R:R:S247	6.61	No	No	0	6	6
181	R:R:L194	R:R:V248	4.47	No	No	0	4	8
182	R:R:F197	R:R:F198	9.65	Yes	No	0	8	5
183	R:R:F197	R:R:L201	6.09	Yes	Yes	1	8	7
184	R:R:F197	R:R:F240	5.36	Yes	No	1	8	9
185	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
186	R:R:F197	R:R:L245	8.53	Yes	No	0	8	6
187	R:R:F197	R:R:V248	5.24	Yes	No	0	8	8
188	R:R:L201	R:R:L205	6.92	Yes	No	0	7	4
189	R:R:F240	R:R:L201	3.65	No	Yes	1	9	7
190	R:R:F206	R:R:R210	5.34	No	No	4	4	4
191	R:R:I233	R:R:S208	4.64	No	No	0	7	8
192	R:R:I211	R:R:I233	4.42	No	No	0	8	7
193	R:R:I212	R:R:I230	10.3	No	No	0	5	6
194	R:R:I212	R:R:I233	5.89	No	No	0	5	7
195	R:R:Q217	R:R:W213	12.05	No	No	0	5	3
196	R:R:I230	R:R:L215	7.14	No	No	0	6	8
197	R:R:D221	R:R:R216	8.34	No	No	0	3	4
198	R:R:M220	R:R:R218	6.2	No	No	0	3	5
199	R:R:Q219	R:R:R222	4.67	No	No	0	3	3
200	R:R:D221	R:R:I230	7	No	No	0	3	6
201	R:R:F232	R:R:F296	7.5	No	No	0	7	8
202	R:R:F232	R:R:S297	11.89	No	No	0	7	6
203	R:R:F240	R:R:F244	10.72	No	Yes	1	9	8
204	R:R:C243	R:R:M285	6.48	No	No	0	8	5
205	R:R:C243	R:R:N286	7.87	No	No	0	8	9
206	R:R:F244	R:R:T283	5.19	Yes	Yes	1	8	8
207	R:R:F244	R:R:N286	8.46	Yes	No	0	8	9
208	R:R:P246	R:R:T279	3.5	No	No	0	9	7
209	R:R:F282	R:R:P246	7.22	No	No	0	7	9
210	R:R:F276	R:R:V250	5.24	Yes	No	0	4	5
211	R:R:F255	R:R:R251	9.62	No	No	1	5	5
212	R:R:F276	R:R:R251	6.41	Yes	No	1	4	5
213	R:R:T260	R:R:W256	8.49	No	No	0	1	4
214	R:R:L257	R:R:Y269	3.52	No	Yes	0	3	2
215	R:R:N265	R:R:V268	4.43	No	No	0	5	1
216	R:R:E267	R:R:R270	5.82	No	No	0	2	1
217	R:R:V268	R:R:Y269	3.79	No	Yes	0	1	2
218	R:R:D273	R:R:F277	7.17	No	Yes	0	4	5
219	R:R:I278	R:R:L274	7.14	No	No	0	6	1
220	R:R:F276	R:R:F277	5.36	Yes	Yes	1	4	5
221	R:R:F276	R:R:L280	6.09	Yes	Yes	1	4	5
222	R:R:L280	R:R:T283	5.9	Yes	Yes	1	5	8
223	R:R:L280	R:R:Y284	3.52	Yes	Yes	1	5	7
224	R:R:T283	R:R:Y284	4.99	Yes	Yes	1	8	7
225	R:R:M285	R:R:M288	8.66	No	No	5	5	8
226	R:R:L289	R:R:M285	15.55	No	No	5	7	5
227	R:R:L289	R:R:M288	8.48	No	No	5	7	8
228	R:R:D290	R:R:Y294	13.79	Yes	Yes	0	9	9
229	R:R:F301	R:R:Y294	4.13	Yes	Yes	0	9	9
230	R:R:F301	R:R:Y295	13.41	Yes	No	0	9	7
231	R:R:P299	R:R:S298	3.56	No	No	0	5	8
232	R:R:F301	R:R:S298	3.96	Yes	No	0	9	8
233	R:R:P299	R:R:S300	3.56	No	No	0	5	5
234	R:R:F304	R:R:S300	6.61	Yes	No	0	4	5
235	R:R:F304	R:R:N303	6.04	Yes	No	0	4	4
236	R:R:L199	R:R:P200	3.28	No	No	0	4	9
237	R:R:S281	R:R:V33	3.23	No	No	0	6	5
238	R:R:D290	R:R:P291	3.22	Yes	No	0	9	9
239	R:R:S247	R:R:T279	3.2	No	No	0	6	7
240	R:R:S261	R:R:T260	3.2	No	No	0	3	1
241	R:R:C53	R:R:L49	3.17	No	No	0	4	7
242	R:R:I254	R:R:V272	3.07	No	No	0	4	4
243	R:R:F82	R:R:W93	3.01	No	Yes	0	6	9
244	R:R:L289	R:R:V239	2.98	No	No	0	7	7
245	R:R:L245	R:R:V241	2.98	No	No	0	6	5
246	R:R:I182	R:R:I254	2.94	Yes	No	0	3	4
247	R:R:I78	R:R:M106	2.92	No	No	0	6	5
248	R:R:I226	R:R:M220	2.92	No	No	0	6	3
249	R:R:I26	R:R:L274	2.85	Yes	No	0	5	1
250	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
251	R:R:I252	R:R:L194	2.85	No	No	0	6	4
252	R:R:I226	R:R:L215	2.85	No	No	0	6	8
253	R:R:I64	R:R:N68	2.83	No	Yes	0	7	9
254	R:R:G96	R:R:W93	2.81	No	Yes	0	7	9
255	R:R:C266	R:R:F21	2.79	No	No	0	7	2
256	R:R:P31	R:R:Y87	2.78	No	Yes	0	6	6
257	R:R:D97	R:R:K166	2.77	No	No	0	3	4
258	R:R:L176	R:R:N171	2.75	No	No	0	4	1
259	R:R:K165	R:R:Q187	2.71	No	No	0	4	2
260	R:R:H223	R:R:I226	2.65	No	No	0	4	6
261	R:R:F282	R:R:S281	2.64	No	No	0	7	6
262	R:R:H184	R:R:K16	2.62	No	No	0	3	4
263	R:R:H134	R:R:L136	2.57	No	No	0	4	4
264	R:R:H184	R:R:L258	2.57	No	No	0	3	3
265	R:R:K60	R:R:R128	2.48	No	Yes	0	7	8
266	R:R:K94	R:R:R89	2.48	No	No	0	3	4
267	R:R:H161	R:R:Q187	2.47	No	No	0	7	2
268	R:R:F52	R:R:L66	2.44	Yes	No	0	7	8
269	R:R:L163	R:R:R101	2.43	No	No	0	5	6
270	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
271	R:R:D8	R:R:F21	2.39	No	No	0	6	2
272	R:R:D23	R:R:F25	2.39	No	No	0	4	6
273	R:R:D85	R:R:F95	2.39	No	No	0	4	7
274	R:R:F232	R:R:R228	2.14	No	No	0	7	7
275	R:R:G172	R:R:G173	2.11	No	No	0	3	4
276	R:R:A122	R:R:C207	1.81	No	Yes	0	9	8
277	R:R:P302	R:R:S298	1.78	No	No	0	8	8
278	R:R:G35	R:R:M84	1.75	No	No	0	5	7
279	R:R:A144	R:R:S61	1.71	No	No	0	7	6
280	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
281	R:R:A237	R:R:S208	1.71	No	No	0	7	8
282	R:R:G172	R:R:N171	1.7	No	No	0	3	1
283	R:R:A108	R:R:T159	1.68	No	No	0	4	7
284	R:R:C207	R:R:I203	1.64	Yes	No	0	8	7
285	R:R:C243	R:R:I242	1.64	No	No	0	8	5
286	R:R:A122	R:R:I204	1.62	No	No	0	9	8
287	R:R:A237	R:R:I204	1.62	No	No	0	7	8
288	R:R:V29	R:R:V33	1.6	No	No	0	5	5
289	R:R:V235	R:R:V292	1.6	No	No	0	5	6
290	R:R:V236	R:R:V292	1.6	No	No	2	8	6
291	R:R:V236	R:R:V293	1.6	No	No	2	8	8
292	R:R:V249	R:R:V250	1.6	No	No	0	6	5
293	R:R:V292	R:R:V293	1.6	No	No	2	6	8
294	R:R:T231	R:R:V235	1.59	No	No	0	6	5
295	R:R:K57	R:R:S58	1.53	No	No	0	5	6
296	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
297	R:R:H133	R:R:P132	1.53	No	No	0	6	8
298	R:R:K28	R:R:V29	1.52	No	No	0	3	5
299	R:R:L75	R:R:V71	1.49	No	No	0	6	6
300	R:R:I146	R:R:I147	1.47	No	No	0	3	5
301	R:R:I238	R:R:I242	1.47	No	No	0	5	5
302	R:R:A135	R:R:H134	1.46	No	No	0	5	4
303	R:R:I212	R:R:M234	1.46	No	No	0	5	4
304	R:R:G262	R:R:Y269	1.45	No	Yes	0	4	2
305	R:R:P302	R:R:R228	1.44	No	No	0	8	7
306	R:R:I182	R:R:L258	1.43	Yes	No	0	3	3
307	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
308	R:R:L195	R:R:L199	1.38	No	No	0	4	4
309	R:R:D221	R:R:K227	1.38	No	No	0	3	4
310	R:R:R142	R:R:S140	1.32	No	No	0	4	6
311	R:R:F40	R:R:I39	1.26	No	No	0	6	5
312	R:R:L257	R:R:R253	1.21	No	No	0	3	5
313	R:R:H223	R:R:R222	1.13	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.825	8	1	0
2	R:R:F10	6.4425	4	0	7
3	R:R:I26	3.894	5	1	5
4	R:R:L34	6.9525	4	1	8
5	R:R:I51	9.075	4	3	7
6	R:R:F52	7.06	4	3	7
7	R:R:F67	5.54	4	0	6
8	R:R:N68	6.414	5	6	9
9	R:R:L69	4.19	4	2	9
10	R:R:D73	8.298	5	2	9
11	R:R:F74	7.19	4	0	7
12	R:R:L80	7.298	5	1	8
13	R:R:Y87	5.65	5	1	6
14	R:R:W91	5.32167	6	1	4
15	R:R:W93	6.76778	9	7	9
16	R:R:Q112	6.015	4	0	7
17	R:R:Y126	7.50286	7	4	7
18	R:R:R128	5.974	5	0	8
19	R:R:V130	8.5175	4	4	8
20	R:R:H131	6.46	4	4	7
21	R:R:L151	5.525	4	0	7
22	R:R:W152	5.3775	4	6	9
23	R:R:F180	8.755	6	1	3
24	R:R:I182	3.05	4	0	3
25	R:R:F197	6.52667	6	1	8
26	R:R:L201	4.5925	4	1	7
27	R:R:C207	2.725	4	0	8
28	R:R:F244	7.49	5	1	8
29	R:R:Y269	3.0975	4	0	2
30	R:R:F276	7.406	5	1	4
31	R:R:F277	5.87	5	1	5
32	R:R:L280	5.372	5	1	5
33	R:R:T283	6.285	4	1	8
34	R:R:Y284	5.7425	8	1	7
35	R:R:D290	8.754	5	2	9
36	R:R:Y294	6.815	4	0	9
37	R:R:F301	8.2	4	0	9
38	R:R:F304	10.735	4	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F277	100	5.65	Yes	Yes	1	0	5
2	R:R:F277	R:R:Y87	31.7429	5.16	Yes	Yes	1	5	6
3	R:R:I26	R:R:Y87	25.8342	3.63	Yes	Yes	1	5	6
4	R:R:I26	R:R:R90	39.0441	3.76	Yes	No	0	5	4
5	R:R:R22	R:R:R90	33.5661	12.79	No	No	0	3	4
6	R:R:D8	R:R:R22	30.8146	5.96	No	No	0	6	3
7	R:R:F277	R:R:W91	73.1496	6.01	Yes	Yes	1	5	4
8	R:R:I26	R:R:W91	29.351	3.52	Yes	Yes	1	5	4
9	R:R:D8	R:R:F21	28.0547	2.39	No	No	0	6	2
10	R:R:C266	R:R:F21	19.7248	2.79	No	No	0	7	2
11	R:R:C19	R:R:C266	16.9315	7.28	No	No	0	4	7
12	R:R:C19	R:R:F10	14.1298	5.59	No	Yes	0	4	7
13	R:R:N86	R:R:W91	45.5758	5.65	No	Yes	0	5	4
14	R:R:N86	R:R:W93	44.3464	10.17	No	Yes	0	5	9
15	R:R:C100	R:R:W93	20.8581	6.53	No	Yes	7	9	9
16	R:R:C100	R:R:M167	19.4572	6.48	No	No	0	9	3
17	R:R:L104	R:R:M167	17.9853	4.24	No	No	0	5	3
18	R:R:L104	R:R:L162	16.5092	5.54	No	No	0	5	4
19	R:R:H161	R:R:L162	15.0247	6.43	No	No	0	7	4
20	R:R:H161	R:R:Q187	13.5276	2.47	No	No	0	7	2
21	R:R:K165	R:R:Q187	12.1644	2.71	No	No	0	4	2
22	R:R:D14	R:R:K165	10.659	6.91	No	No	0	5	4
23	R:R:D273	R:R:F277	21.8282	7.17	No	Yes	0	4	5
24	R:R:D273	R:R:I182	20.4148	4.2	No	Yes	0	4	3
25	R:R:I26	R:R:L274	14.1005	2.85	Yes	No	0	5	1
26	L:L:?1	R:R:Y284	40.9091	6.52	Yes	Yes	1	0	7
27	L:L:?1	R:R:R111	61.1023	10.14	Yes	No	0	0	8
28	R:R:R111	R:R:T283	16.1746	9.06	No	Yes	0	8	8
29	R:R:F244	R:R:T283	61.809	5.19	Yes	Yes	1	8	8
30	R:R:F244	R:R:N286	24.4167	8.46	Yes	No	0	8	9
31	R:R:C243	R:R:N286	22.0122	7.87	No	No	0	8	9
32	R:R:C243	R:R:M285	14.7487	6.48	No	No	0	8	5
33	L:L:?1	R:R:L280	13.1471	7.7	Yes	Yes	1	0	5
34	R:R:L280	R:R:T283	28.7279	5.9	Yes	Yes	1	5	8
35	R:R:T283	R:R:Y284	28.8116	4.99	Yes	Yes	1	8	7
36	R:R:L76	R:R:Y284	42.1678	3.52	No	Yes	0	7	7
37	R:R:L76	R:R:S287	39.6462	9.01	No	No	0	7	8
38	R:R:D73	R:R:S287	41.1851	10.31	Yes	No	0	9	8
39	R:R:D73	R:R:N45	12.2481	5.39	Yes	No	2	9	9
40	R:R:F74	R:R:N45	13.582	14.5	Yes	No	0	7	9
41	R:R:D290	R:R:D73	20.8079	17.3	Yes	Yes	2	9	9
42	R:R:D290	R:R:Y294	20.2225	13.79	Yes	Yes	0	9	9
43	R:R:E196	R:R:R111	54.8758	3.49	No	No	0	5	8
44	R:R:E196	R:R:Q112	50.1714	10.19	No	Yes	0	5	7
45	R:R:I116	R:R:Q112	37.3003	4.12	No	Yes	0	5	7
46	R:R:I116	R:R:L151	38.3625	5.71	No	Yes	0	5	7
47	R:R:F117	R:R:L151	34.1432	6.09	No	Yes	0	8	7
48	R:R:F117	R:R:N68	28.8534	13.29	No	Yes	6	8	9
49	R:R:F67	R:R:N68	16.2708	3.62	Yes	Yes	0	6	9
50	R:R:F74	R:R:L49	11.1776	4.87	Yes	No	0	7	7
51	R:R:F67	R:R:L49	10.3956	3.65	Yes	No	0	6	7
52	R:R:F301	R:R:Y294	17.0611	4.13	Yes	Yes	0	9	9
53	R:R:F52	R:R:F67	13.9625	9.65	Yes	Yes	0	7	6
54	R:R:I64	R:R:N68	20.1137	2.83	No	Yes	0	7	9
55	R:R:A144	R:R:I64	15.9112	4.87	No	No	0	7	7
56	R:R:A144	R:R:S61	14.4936	1.71	No	No	0	7	6
57	R:R:Q112	R:R:T155	13.2433	5.67	Yes	No	0	7	7
58	R:R:M109	R:R:T155	13.5904	4.52	No	No	0	5	7
59	R:R:I156	R:R:M109	12.2313	5.83	No	No	0	4	5
60	R:R:E196	R:R:I115	36.1964	6.83	No	No	0	5	8
61	R:R:I115	R:R:P200	46.1111	3.39	No	No	0	8	9
62	R:R:P200	R:R:T119	43.1003	3.5	No	No	0	9	7
63	R:R:I203	R:R:T119	42.08	6.08	No	No	0	7	7
64	R:R:C207	R:R:I203	41.0513	1.64	Yes	No	0	8	7
65	R:R:C207	R:R:Y126	34.4443	4.03	Yes	Yes	0	8	7
66	R:R:I211	R:R:Y126	21.0504	2.42	No	Yes	0	8	7
67	R:R:F276	R:R:F277	20.5403	5.36	Yes	Yes	1	4	5
68	R:R:F276	R:R:L280	18.3073	6.09	Yes	Yes	1	4	5
69	L:L:?1	R:R:F180	13.214	11.29	Yes	Yes	1	0	3
70	R:R:F180	R:R:F193	18.5874	5.36	Yes	No	0	3	6
71	R:R:F193	R:R:S247	16.6555	6.61	No	No	0	6	6
72	R:R:F197	R:R:F244	24.2494	4.29	Yes	Yes	1	8	8
73	R:R:I211	R:R:I233	18.6878	4.42	No	No	0	8	7
74	R:R:I212	R:R:I233	16.5092	5.89	No	No	0	5	7
75	R:R:I212	R:R:I230	14.0587	10.3	No	No	0	5	6
76	R:R:F301	R:R:S298	10.1363	3.96	Yes	No	0	9	8
77	R:R:S247	R:R:T279	14.6023	3.2	No	No	0	6	7
78	R:R:P246	R:R:T279	12.5408	3.5	No	No	0	9	7
79	R:R:F282	R:R:P246	10.4709	7.22	No	No	0	7	9
80	R:R:F244	R:R:I115	22.1878	8.79	Yes	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L107	11.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	10.14	1	Yes	No	0	8	0	1
L:L:?1	R:R:S178	5.57	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	4.18	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	11.29	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:F277	5.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	7.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y284	6.52	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:L34	15.9	1	No	Yes	7	8	2	2
R:R:L34	R:R:L80	4.15	1	Yes	Yes	8	8	2	2
R:R:L34	R:R:Y284	3.52	1	Yes	Yes	8	7	2	1
R:R:E37	R:R:L80	14.58	1	No	Yes	7	8	2	2
R:R:E37	R:R:Y284	16.83	1	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	3.52	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	11.11	0	No	No	6	6	2	1
R:R:L80	R:R:Y284	3.52	1	Yes	Yes	8	7	2	1
R:R:W91	R:R:Y87	9.65	1	Yes	Yes	4	6	2	2
R:R:F277	R:R:Y87	5.16	1	Yes	Yes	5	6	1	2
R:R:F277	R:R:W91	6.01	1	Yes	Yes	5	4	1	2
R:R:L107	R:R:Y284	3.52	1	No	Yes	6	7	1	1
R:R:E196	R:R:R111	3.49	0	No	No	5	8	2	1
R:R:R111	R:R:T283	9.06	0	No	Yes	8	8	1	2
R:R:F180	R:R:S179	9.25	1	Yes	No	3	4	1	1
R:R:H189	R:R:S179	6.97	1	No	No	5	4	2	1
R:R:F180	R:R:H189	9.05	1	Yes	No	3	5	1	2
R:R:F180	R:R:F193	5.36	1	Yes	No	3	6	1	2
R:R:F180	R:R:F276	13.93	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	Yes	3	5	1	1
R:R:D273	R:R:F277	7.17	0	No	Yes	4	5	2	1
R:R:F276	R:R:F277	5.36	1	Yes	Yes	4	5	2	1
R:R:F276	R:R:L280	6.09	1	Yes	Yes	4	5	2	1
R:R:L280	R:R:T283	5.9	1	Yes	Yes	5	8	1	2
R:R:L280	R:R:Y284	3.52	1	Yes	Yes	5	7	1	1
R:R:T283	R:R:Y284	4.99	1	Yes	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IY9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	277
Number of Links	313
Number of Hubs	38
Number of Links mediated by Hubs	148
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	56438
Length Of Smallest Path	3
Average Path Length	12.9983
Length of Longest Path	34
Minimum Path Strength	1.53
Average Path Strength	6.02112
Maximum Path Strength	15.545
Minimum Path Correlation	0.7
Average Path Correlation	0.929497
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	52.6417
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.961
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • nicotinic acid receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • cell surface receptor signaling pathway • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • myeloid cell apoptotic process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • protein localization • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • cellular macromolecule localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • cellular localization • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • regulation of cellular localization • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	3-carboxypyridine
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>8IY9_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F P N F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	10.1016/j.celrep.2023.113406
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	10.1038/s41467-024-46239-2
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	10.1038/s41467-024-46239-2
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	10.1038/s41467-023-42764-8
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	10.1016/j.celrep.2023.113406
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	10.1038/s41421-023-00610-7
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	10.1038/s41467-023-43537-z
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	10.1038/s41467-023-43537-z
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	10.1038/s41467-023-42764-8
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	To be published
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	To be published
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	10.1038/s41392-023-01625-y
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	10.1038/s41467-023-41650-7
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	10.1016/j.molcel.2023.07.030
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	10.1038/s41467-023-41650-7
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	10.1038/s41467-023-41650-7
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	10.1038/s41467-023-37177-6
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	10.1038/s41467-023-37177-6
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795

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