psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	10.05	Yes	No	0	0	6
2	L:L:?1	R:R:N86	9.97	Yes	No	1	0	5
3	L:L:?1	R:R:Y87	4.26	Yes	Yes	1	0	6
4	L:L:?1	R:R:W91	4.14	Yes	Yes	1	0	4
5	L:L:?1	R:R:L104	5.03	Yes	No	1	0	5
6	L:L:?1	R:R:L107	8.04	Yes	No	1	0	6
7	L:L:?1	R:R:R111	11.47	Yes	No	0	0	8
8	L:L:?1	R:R:S179	9.81	Yes	No	1	0	4
9	L:L:?1	R:R:F180	15.04	Yes	Yes	1	0	3
10	L:L:?1	R:R:H189	3.73	Yes	Yes	1	0	5
11	L:L:?1	R:R:F277	3.54	Yes	Yes	1	0	5
12	L:L:?1	R:R:L280	7.04	Yes	No	0	0	5
13	L:L:?1	R:R:Y284	6.81	Yes	Yes	1	0	7
14	R:R:F21	R:R:H9	18.1	Yes	No	0	2	6
15	R:R:E267	R:R:H9	9.85	No	No	0	2	6
16	R:R:F10	R:R:N17	12.08	No	No	4	7	5
17	R:R:F10	R:R:T263	3.89	No	Yes	4	7	3
18	R:R:E12	R:R:L11	3.98	No	No	0	5	8
19	R:R:I13	R:R:L11	5.71	No	No	0	3	8
20	R:R:L11	R:R:N171	9.61	No	No	0	8	1
21	R:R:C18	R:R:I13	6.55	No	No	0	9	3
22	R:R:I13	R:R:S181	3.1	No	No	0	3	4
23	R:R:D14	R:R:K15	5.53	No	No	0	5	3
24	R:R:N17	R:R:T263	5.85	No	Yes	4	5	3
25	R:R:C18	R:R:C183	7.28	No	No	0	9	1
26	R:R:C19	R:R:C266	7.28	No	No	4	4	7
27	R:R:N171	R:R:V20	4.43	No	No	0	1	2
28	R:R:L176	R:R:V20	4.47	No	No	0	4	2
29	R:R:S181	R:R:V20	3.23	No	No	0	4	2
30	R:R:C266	R:R:F21	4.19	No	Yes	0	7	2
31	R:R:F21	R:R:R270	6.41	Yes	No	0	2	1
32	R:R:D273	R:R:F21	8.36	No	Yes	0	4	2
33	R:R:R22	R:R:R90	12.79	No	No	0	3	4
34	R:R:R22	R:R:W91	5	No	Yes	0	3	4
35	R:R:A174	R:R:R22	4.15	No	No	0	2	3
36	R:R:D23	R:R:D24	7.98	No	No	0	4	4
37	R:R:D23	R:R:F25	4.78	No	No	0	4	6
38	R:R:I26	R:R:Y87	3.63	Yes	Yes	1	5	6
39	R:R:I26	R:R:W91	5.87	Yes	Yes	1	5	4
40	R:R:I26	R:R:L274	4.28	Yes	No	0	5	1
41	R:R:F277	R:R:I26	3.77	Yes	Yes	1	5	5
42	R:R:L30	R:R:L34	4.15	Yes	No	1	5	8
43	R:R:L30	R:R:Y87	9.38	Yes	Yes	1	5	6
44	R:R:I278	R:R:L30	4.28	No	Yes	0	6	5
45	R:R:P31	R:R:P32	5.84	No	No	0	6	5
46	R:R:L34	R:R:Y87	3.52	No	Yes	1	8	6
47	R:R:G35	R:R:M84	3.49	No	No	0	5	7
48	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
49	R:R:F38	R:R:L42	13.4	No	No	0	7	7
50	R:R:F38	R:R:L80	4.87	No	No	0	7	8
51	R:R:F38	R:R:P81	5.78	No	No	0	7	8
52	R:R:F40	R:R:M288	4.98	No	No	0	6	8
53	R:R:G44	R:R:P291	4.06	No	No	0	7	9
54	R:R:F74	R:R:N45	4.83	No	No	0	7	9
55	R:R:N45	R:R:P291	4.89	No	No	0	9	9
56	R:R:I51	R:R:L47	4.28	Yes	No	0	7	6
57	R:R:F296	R:R:L47	6.09	No	No	0	8	6
58	R:R:A48	R:R:F296	4.16	No	No	0	9	8
59	R:R:F67	R:R:L49	4.87	Yes	No	0	6	7
60	R:R:F74	R:R:L49	3.65	No	No	0	7	7
61	R:R:I51	R:R:L56	4.28	Yes	No	2	7	5
62	R:R:F301	R:R:I51	7.54	Yes	Yes	2	9	7
63	R:R:F52	R:R:F67	15	No	Yes	0	7	6
64	R:R:F52	R:R:Y295	5.16	No	Yes	2	7	7
65	R:R:F301	R:R:F52	7.5	Yes	No	2	9	7
66	R:R:F54	R:R:H55	3.39	No	No	0	4	5
67	R:R:L56	R:R:R63	6.07	No	No	2	5	7
68	R:R:F301	R:R:L56	8.53	Yes	No	2	9	5
69	R:R:R63	R:R:S58	3.95	No	No	0	7	6
70	R:R:I64	R:R:W59	4.7	No	No	0	7	6
71	R:R:F67	R:R:W59	7.02	Yes	No	0	6	6
72	R:R:I139	R:R:S61	7.74	No	No	0	7	6
73	R:R:A144	R:R:S61	3.42	No	No	0	7	6
74	R:R:R128	R:R:S62	5.27	No	No	0	8	8
75	R:R:F301	R:R:R63	3.21	Yes	No	2	9	7
76	R:R:I64	R:R:N141	4.25	No	No	0	7	2
77	R:R:A144	R:R:I64	4.87	No	No	0	7	7
78	R:R:F65	R:R:V120	9.18	No	No	0	7	7
79	R:R:L66	R:R:Y294	4.69	No	Yes	2	8	9
80	R:R:L66	R:R:Y295	7.03	No	Yes	2	8	7
81	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
82	R:R:F117	R:R:N68	15.71	No	No	5	8	9
83	R:R:N68	R:R:S148	8.94	No	No	0	9	8
84	R:R:N68	R:R:W152	5.65	No	Yes	5	9	9
85	R:R:D73	R:R:L69	5.43	No	No	2	9	9
86	R:R:D290	R:R:L69	4.07	Yes	No	2	9	9
87	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
88	R:R:D73	R:R:S287	10.31	No	No	0	9	8
89	R:R:D290	R:R:D73	6.65	Yes	No	2	9	9
90	R:R:F74	R:R:I78	10.05	No	No	0	7	6
91	R:R:L75	R:R:N110	5.49	No	Yes	0	6	9
92	R:R:L76	R:R:N110	5.49	No	Yes	0	7	9
93	R:R:L76	R:R:Y284	4.69	No	Yes	0	7	7
94	R:R:I77	R:R:L80	4.28	No	No	0	6	8
95	R:R:I77	R:R:S287	6.19	No	No	0	6	8
96	R:R:C79	R:R:L107	3.17	No	No	0	6	6
97	R:R:F82	R:R:F95	6.43	No	Yes	0	6	7
98	R:R:F82	R:R:M103	3.73	No	No	0	6	5
99	R:R:D85	R:R:R89	5.96	No	No	0	4	4
100	R:R:D85	R:R:F95	4.78	No	Yes	0	4	7
101	R:R:N86	R:R:W91	7.91	No	Yes	1	5	4
102	R:R:N86	R:R:W93	5.65	No	Yes	1	5	9
103	R:R:W91	R:R:Y87	6.75	Yes	Yes	1	4	6
104	R:R:K94	R:R:R89	8.66	No	No	0	3	4
105	R:R:F277	R:R:W91	8.02	Yes	Yes	1	5	4
106	R:R:D92	R:R:K94	6.91	No	No	0	4	3
107	R:R:A174	R:R:D92	3.09	No	No	0	2	4
108	R:R:F95	R:R:W93	10.02	Yes	Yes	0	7	9
109	R:R:C100	R:R:W93	6.53	Yes	Yes	1	9	9
110	R:R:C177	R:R:W93	14.37	No	Yes	1	9	9
111	R:R:F95	R:R:P99	7.22	Yes	No	0	7	5
112	R:R:G96	R:R:P99	4.06	No	No	0	7	5
113	R:R:D97	R:R:K166	5.53	No	No	0	3	4
114	R:R:D97	R:R:P168	12.88	No	No	0	3	4
115	R:R:I98	R:R:P99	3.39	No	No	0	2	5
116	R:R:I98	R:R:R101	7.52	No	No	0	2	6
117	R:R:C100	R:R:M167	4.86	Yes	No	0	9	3
118	R:R:C100	R:R:P168	3.77	Yes	No	0	9	4
119	R:R:C100	R:R:C177	7.28	Yes	No	1	9	9
120	R:R:L163	R:R:R101	10.93	No	No	0	5	6
121	R:R:L104	R:R:S179	6.01	No	No	1	5	4
122	R:R:F105	R:R:M109	8.71	No	Yes	0	6	5
123	R:R:F105	R:R:L163	7.31	No	No	0	6	5
124	R:R:M106	R:R:N110	8.41	No	Yes	0	5	9
125	R:R:L107	R:R:Y284	3.52	No	Yes	1	6	7
126	R:R:A108	R:R:T159	3.36	No	No	0	4	7
127	R:R:M109	R:R:N110	5.61	Yes	Yes	0	5	9
128	R:R:M109	R:R:W152	3.49	Yes	Yes	0	5	9
129	R:R:I156	R:R:M109	5.83	No	Yes	0	4	5
130	R:R:L158	R:R:Q112	6.65	No	No	0	5	7
131	R:R:M192	R:R:Q112	5.44	Yes	No	0	5	7
132	R:R:G113	R:R:T155	3.64	No	No	0	7	7
133	R:R:I115	R:R:S114	3.1	Yes	No	0	8	9
134	R:R:E196	R:R:I115	4.1	No	Yes	0	5	8
135	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
136	R:R:F240	R:R:I115	3.77	Yes	Yes	2	9	8
137	R:R:F244	R:R:I115	8.79	Yes	Yes	2	8	8
138	R:R:I116	R:R:L151	4.28	No	Yes	0	5	7
139	R:R:F117	R:R:W152	11.02	No	Yes	5	8	9
140	R:R:F240	R:R:L118	3.65	Yes	No	0	9	9
141	R:R:P200	R:R:T119	6.99	No	No	0	9	7
142	R:R:I203	R:R:T119	3.04	No	No	0	7	7
143	R:R:R125	R:R:V121	5.23	No	No	0	9	9
144	R:R:D124	R:R:R128	9.53	No	No	0	8	8
145	R:R:R125	R:R:Y294	4.12	No	Yes	0	9	9
146	R:R:F127	R:R:Y126	5.16	Yes	Yes	3	5	7
147	R:R:V130	R:R:Y126	12.62	Yes	Yes	3	8	7
148	R:R:H131	R:R:Y126	6.53	Yes	Yes	3	7	7
149	R:R:F206	R:R:Y126	4.13	No	Yes	3	4	7
150	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
151	R:R:R210	R:R:Y126	7.2	Yes	Yes	3	4	7
152	R:R:F127	R:R:H131	3.39	Yes	Yes	3	5	7
153	R:R:F127	R:R:H134	7.92	Yes	Yes	3	5	4
154	R:R:F127	R:R:L136	4.87	Yes	No	3	5	4
155	R:R:N137	R:R:R128	6.03	No	No	0	4	8
156	R:R:I211	R:R:V129	7.68	No	No	0	8	8
157	R:R:L215	R:R:V129	4.47	No	No	0	8	8
158	R:R:H131	R:R:V130	4.15	Yes	Yes	3	7	8
159	R:R:R210	R:R:V130	3.92	Yes	Yes	3	4	8
160	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
161	R:R:H134	R:R:L136	6.43	Yes	No	3	4	4
162	R:R:S140	R:R:T143	4.8	No	No	0	6	3
163	R:R:A145	R:R:R142	4.15	No	No	0	3	4
164	R:R:I147	R:R:T143	3.04	No	No	0	5	3
165	R:R:I154	R:R:L150	4.28	No	No	0	5	4
166	R:R:T155	R:R:W152	3.64	No	Yes	0	7	9
167	R:R:H161	R:R:L162	9	No	No	0	7	4
168	R:R:H161	R:R:W188	3.17	No	No	0	7	5
169	R:R:I169	R:R:L176	7.14	No	No	0	1	4
170	R:R:H189	R:R:S179	5.58	Yes	No	1	5	4
171	R:R:F180	R:R:H189	9.05	Yes	Yes	1	3	5
172	R:R:E190	R:R:F180	5.83	Yes	Yes	1	4	3
173	R:R:F180	R:R:F193	8.57	Yes	Yes	1	3	6
174	R:R:F180	R:R:R251	3.21	Yes	Yes	1	3	5
175	R:R:F180	R:R:F276	4.29	Yes	Yes	1	3	4
176	R:R:C183	R:R:S181	3.44	No	No	0	1	4
177	R:R:I182	R:R:Y269	6.04	No	Yes	0	3	2
178	R:R:D273	R:R:I182	5.6	No	No	0	4	3
179	R:R:G262	R:R:H184	3.18	No	No	0	4	3
180	R:R:A191	R:R:F186	4.16	No	No	0	3	4
181	R:R:H189	R:R:Q187	3.71	Yes	No	0	5	2
182	R:R:E190	R:R:Q187	10.19	Yes	No	0	4	2
183	R:R:M192	R:R:W188	6.98	Yes	No	0	5	5
184	R:R:H189	R:R:M192	3.94	Yes	Yes	0	5	5
185	R:R:E190	R:R:R251	11.63	Yes	Yes	1	4	5
186	R:R:E190	R:R:F255	4.66	Yes	No	1	4	5
187	R:R:E196	R:R:F193	7	No	Yes	0	5	6
188	R:R:F193	R:R:R251	5.34	Yes	Yes	1	6	5
189	R:R:F193	R:R:F276	3.22	Yes	Yes	1	6	4
190	R:R:I252	R:R:L194	4.28	No	No	0	6	4
191	R:R:F197	R:R:F198	7.5	Yes	No	0	8	5
192	R:R:F197	R:R:L201	7.31	Yes	Yes	0	8	7
193	R:R:F197	R:R:F240	6.43	Yes	Yes	0	8	9
194	R:R:F197	R:R:L245	3.65	Yes	Yes	0	8	6
195	R:R:F197	R:R:V248	9.18	Yes	No	0	8	8
196	R:R:F206	R:R:R210	6.41	No	Yes	3	4	4
197	R:R:I233	R:R:S208	3.1	No	No	0	7	8
198	R:R:R210	R:R:W213	5	Yes	No	0	4	3
199	R:R:I211	R:R:I233	4.42	No	No	0	8	7
200	R:R:I212	R:R:I230	7.36	No	No	7	5	6
201	R:R:S214	R:R:W213	7.41	No	No	0	5	3
202	R:R:Q217	R:R:W213	13.14	No	No	0	5	3
203	R:R:M220	R:R:R218	6.2	No	No	0	3	5
204	R:R:D221	R:R:K227	6.91	No	No	0	3	4
205	R:R:H223	R:R:K225	13.1	No	No	0	4	5
206	R:R:P299	R:R:R228	7.21	No	No	0	5	7
207	R:R:F232	R:R:S297	6.61	No	No	0	7	6
208	R:R:V236	R:R:Y294	6.31	No	Yes	0	8	9
209	R:R:F240	R:R:F244	4.29	Yes	Yes	2	9	8
210	R:R:C243	R:R:F244	4.19	No	Yes	2	8	8
211	R:R:C243	R:R:N286	9.45	No	No	2	8	9
212	R:R:F244	R:R:T283	6.49	Yes	No	0	8	8
213	R:R:F244	R:R:N286	12.08	Yes	No	2	8	9
214	R:R:L245	R:R:P246	3.28	Yes	No	0	6	9
215	R:R:P246	R:R:T279	5.25	No	Yes	0	9	7
216	R:R:S247	R:R:T279	4.8	No	Yes	0	6	7
217	R:R:F276	R:R:V250	6.55	Yes	No	0	4	5
218	R:R:T279	R:R:V250	3.17	Yes	No	0	7	5
219	R:R:I254	R:R:R251	8.77	No	Yes	0	4	5
220	R:R:F255	R:R:R251	6.41	No	Yes	1	5	5
221	R:R:F276	R:R:R251	10.69	Yes	Yes	1	4	5
222	R:R:I254	R:R:V272	4.61	No	No	0	4	4
223	R:R:L257	R:R:V268	5.96	No	No	6	3	1
224	R:R:L257	R:R:Y269	5.86	No	Yes	6	3	2
225	R:R:L258	R:R:Y269	8.21	No	Yes	0	3	2
226	R:R:S261	R:R:T260	3.2	No	No	0	3	1
227	R:R:E267	R:R:R270	16.28	No	No	0	2	1
228	R:R:V268	R:R:Y269	5.05	No	Yes	6	1	2
229	R:R:F276	R:R:L280	3.65	Yes	No	0	4	5
230	R:R:F282	R:R:T279	3.89	No	Yes	0	7	7
231	R:R:S281	R:R:Y284	3.82	No	Yes	0	6	7
232	R:R:F282	R:R:M285	4.98	No	No	0	7	5
233	R:R:T283	R:R:Y284	6.24	No	Yes	0	8	7
234	R:R:D290	R:R:N286	5.39	Yes	No	2	9	9
235	R:R:D290	R:R:Y294	8.05	Yes	Yes	2	9	9
236	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
237	R:R:Y294	R:R:Y295	5.96	Yes	Yes	2	9	7
238	R:R:F301	R:R:Y295	3.09	Yes	Yes	2	9	7
239	R:R:F296	R:R:F301	3.22	No	Yes	0	8	9
240	R:R:P299	R:R:S298	3.56	No	No	0	5	8
241	R:R:S298	R:R:S300	3.26	No	No	0	8	5
242	R:R:F54	R:R:W50	3.01	No	No	0	4	4
243	R:R:M109	R:R:T159	3.01	Yes	No	0	5	7
244	R:R:M192	R:R:T159	3.01	Yes	No	0	5	7
245	R:R:K16	R:R:T185	3	No	No	0	4	2
246	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
247	R:R:I212	R:R:I233	2.94	No	No	0	5	7
248	R:R:I238	R:R:I242	2.94	No	No	0	5	5
249	R:R:I169	R:R:M167	2.92	No	No	0	1	3
250	R:R:I212	R:R:M234	2.92	No	No	7	5	4
251	R:R:I230	R:R:M234	2.92	No	No	7	6	4
252	R:R:M285	R:R:M288	2.89	No	No	0	5	8
253	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
254	R:R:I226	R:R:L215	2.85	No	No	0	6	8
255	R:R:Q187	R:R:T185	2.83	No	No	0	2	2
256	R:R:L215	R:R:M220	2.83	No	No	0	8	3
257	R:R:L289	R:R:M285	2.83	No	No	0	7	5
258	R:R:D23	R:R:I26	2.8	No	Yes	0	4	5
259	R:R:C53	R:R:F54	2.79	No	No	0	4	4
260	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
261	R:R:F65	R:R:S148	2.64	No	No	0	7	8
262	R:R:F301	R:R:S298	2.64	Yes	No	0	9	8
263	R:R:F25	R:R:V29	2.62	No	No	0	6	5
264	R:R:R90	R:R:V27	2.62	No	No	0	4	3
265	R:R:R89	R:R:V88	2.62	No	No	0	4	3
266	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
267	R:R:R253	R:R:V272	2.62	No	No	0	5	4
268	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
269	R:R:A191	R:R:W188	2.59	No	No	0	3	5
270	R:R:H184	R:R:L258	2.57	No	No	0	3	3
271	R:R:F117	R:R:L151	2.44	No	Yes	0	8	7
272	R:R:F255	R:R:L194	2.44	No	No	0	5	4
273	R:R:T260	R:R:W256	2.43	No	No	0	1	4
274	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
275	R:R:F232	R:R:R228	2.14	No	No	0	7	7
276	R:R:G172	R:R:G173	2.11	No	No	0	3	4
277	R:R:G262	R:R:S261	1.86	No	No	0	4	3
278	R:R:G41	R:R:I77	1.76	No	No	0	8	6
279	R:R:G153	R:R:I156	1.76	No	No	0	4	4
280	R:R:G157	R:R:I156	1.76	No	No	0	5	4
281	R:R:G35	R:R:L34	1.71	No	No	0	5	8
282	R:R:G44	R:R:L43	1.71	No	No	0	7	4
283	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
284	R:R:C243	R:R:V239	1.71	No	No	0	8	7
285	R:R:G172	R:R:N171	1.7	No	No	0	3	1
286	R:R:C19	R:R:T263	1.69	No	Yes	4	4	3
287	R:R:C266	R:R:T263	1.69	No	Yes	4	7	3
288	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
289	R:R:G173	R:R:Q170	1.64	No	No	0	4	1
290	R:R:L199	R:R:P200	1.64	No	No	0	4	9
291	R:R:C207	R:R:I203	1.64	No	No	0	8	7
292	R:R:S281	R:R:V33	1.62	No	No	0	6	5
293	R:R:A122	R:R:I204	1.62	No	No	0	9	8
294	R:R:A237	R:R:I204	1.62	No	No	0	7	8
295	R:R:V235	R:R:V239	1.6	No	No	0	5	7
296	R:R:V235	R:R:V293	1.6	No	No	0	5	8
297	R:R:A237	R:R:L205	1.58	No	No	0	7	4
298	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
299	R:R:H133	R:R:P132	1.53	No	No	0	6	8
300	R:R:M234	R:R:T231	1.51	No	No	0	4	6
301	R:R:L163	R:R:V160	1.49	No	No	0	5	4
302	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
303	R:R:L245	R:R:V241	1.49	Yes	No	0	6	5
304	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
305	R:R:I39	R:R:L42	1.43	No	No	0	5	7
306	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
307	R:R:I154	R:R:L158	1.43	No	No	0	5	5
308	R:R:D221	R:R:I226	1.4	No	No	0	3	6
309	R:R:D24	R:R:K28	1.38	No	No	0	4	3
310	R:R:H55	R:R:I51	1.33	No	Yes	0	5	7
311	R:R:H223	R:R:I226	1.33	No	No	0	4	6
312	R:R:F180	R:R:S178	1.32	Yes	No	0	3	4
313	R:R:F277	R:R:S178	1.32	Yes	No	0	5	4
314	R:R:N265	R:R:Q264	1.32	No	No	0	5	3
315	R:R:H134	R:R:N137	1.28	Yes	No	0	4	4
316	R:R:V272	R:R:Y269	1.26	No	Yes	0	4	2
317	R:R:I146	R:R:R142	1.25	No	No	0	3	4
318	R:R:F40	R:R:L36	1.22	No	No	0	6	4
319	R:R:D221	R:R:R216	1.19	No	No	0	3	4
320	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.61	13	1	0
2	R:R:F21	9.265	4	0	2
3	R:R:I26	4.07	5	1	5
4	R:R:L30	4.8625	4	1	5
5	R:R:I51	4.3575	4	2	7
6	R:R:F67	8.69	4	0	6
7	R:R:Y87	5.508	5	1	6
8	R:R:W91	6.28167	6	1	4
9	R:R:W93	7.54	5	1	9
10	R:R:F95	7.1125	4	0	7
11	R:R:C100	5.61	4	1	9
12	R:R:M109	5.33	5	0	5
13	R:R:N110	6.25	4	0	9
14	R:R:I115	4.63	5	2	8
15	R:R:Y126	6.78143	7	3	7
16	R:R:F127	4.792	5	3	5
17	R:R:V130	6.385	4	3	8
18	R:R:H131	3.9	4	3	7
19	R:R:H134	4.2725	4	3	4
20	R:R:L151	2.75	4	0	7
21	R:R:W152	5.278	5	5	9
22	R:R:F180	6.75857	7	1	3
23	R:R:H189	5.202	5	1	5
24	R:R:E190	8.0775	4	1	4
25	R:R:M192	4.8425	4	0	5
26	R:R:F193	6.0325	4	1	6
27	R:R:F197	6.814	5	0	8
28	R:R:L201	3.32	4	0	7
29	R:R:R210	5.6325	4	3	4
30	R:R:F240	4.535	4	2	9
31	R:R:F244	7.168	5	2	8
32	R:R:L245	2.85	4	0	6
33	R:R:R251	7.675	6	1	5
34	R:R:T263	3.28	4	4	3
35	R:R:Y269	5.284	5	6	2
36	R:R:F276	5.68	5	1	4
37	R:R:F277	4.1625	4	1	5
38	R:R:T279	4.2775	4	0	7
39	R:R:Y284	4.74167	6	1	7
40	R:R:D290	6.04	4	2	9
41	R:R:Y294	5.48667	6	2	9
42	R:R:Y295	5.048	5	2	7
43	R:R:F301	5.10429	7	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F180	52.9559	15.04	Yes	Yes	1	0	3
2	R:R:F180	R:R:R251	25.9074	3.21	Yes	Yes	1	3	5
3	R:R:I254	R:R:R251	46.06	8.77	No	Yes	0	4	5
4	R:R:I254	R:R:V272	44.2915	4.61	No	No	0	4	4
5	R:R:V272	R:R:Y269	40.7117	1.26	No	Yes	0	4	2
6	R:R:I182	R:R:Y269	23.8893	6.04	No	Yes	0	3	2
7	R:R:D273	R:R:I182	21.9354	5.6	No	No	0	4	3
8	R:R:D273	R:R:F21	19.9815	8.36	No	Yes	0	4	2
9	R:R:C266	R:R:F21	10.3188	4.19	No	Yes	0	7	2
10	L:L:?1	R:R:N86	66.1128	9.97	Yes	No	1	0	5
11	R:R:N86	R:R:W93	69.8353	5.65	No	Yes	1	5	9
12	R:R:C100	R:R:W93	45.6892	6.53	Yes	Yes	1	9	9
13	R:R:C100	R:R:M167	36.5257	4.86	Yes	No	0	9	3
14	R:R:I169	R:R:M167	34.1653	2.92	No	No	0	1	3
15	R:R:I169	R:R:L176	31.7906	7.14	No	No	0	1	4
16	R:R:L176	R:R:V20	29.3946	4.47	No	No	0	4	2
17	R:R:N171	R:R:V20	14.9825	4.43	No	No	0	1	2
18	R:R:S181	R:R:V20	12.2584	3.23	No	No	0	4	2
19	L:L:?1	R:R:W91	28.9382	4.14	Yes	Yes	1	0	4
20	R:R:R22	R:R:W91	14.6331	5	No	Yes	0	3	4
21	L:L:?1	R:R:Y87	32.7676	4.26	Yes	Yes	1	0	6
22	R:R:I26	R:R:Y87	15.1679	3.63	Yes	Yes	1	5	6
23	R:R:D23	R:R:I26	36.7183	2.8	No	Yes	0	4	5
24	R:R:I26	R:R:W91	16.8652	5.87	Yes	Yes	1	5	4
25	L:L:?1	R:R:F277	17.072	3.54	Yes	Yes	1	0	5
26	R:R:F277	R:R:I26	19.033	3.77	Yes	Yes	1	5	5
27	R:R:D23	R:R:D24	14.7258	7.98	No	No	0	4	4
28	R:R:D23	R:R:F25	14.7258	4.78	No	No	0	4	6
29	R:R:L30	R:R:Y87	10.9463	9.38	Yes	Yes	1	5	6
30	L:L:?1	R:R:Y284	86.5293	6.81	Yes	Yes	1	0	7
31	R:R:T283	R:R:Y284	99.7647	6.24	No	Yes	0	8	7
32	R:R:F244	R:R:T283	99.3939	6.49	Yes	No	0	8	8
33	R:R:F244	R:R:N286	89.6242	12.08	Yes	No	2	8	9
34	R:R:D290	R:R:N286	88.797	5.39	Yes	No	2	9	9
35	R:R:D290	R:R:D73	18.0917	6.65	Yes	No	2	9	9
36	R:R:D73	R:R:S287	16.1948	10.31	No	No	0	9	8
37	R:R:I77	R:R:S287	14.2195	6.19	No	No	0	6	8
38	R:R:I77	R:R:L80	10.2261	4.28	No	No	0	6	8
39	R:R:F180	R:R:F276	13.107	4.29	Yes	Yes	1	3	4
40	R:R:F276	R:R:V250	26.6919	6.55	Yes	No	0	4	5
41	R:R:T279	R:R:V250	24.2887	3.17	Yes	No	0	7	5
42	R:R:F282	R:R:T279	18.4768	3.89	No	Yes	0	7	7
43	R:R:F282	R:R:M285	15.4318	4.98	No	No	0	7	5
44	R:R:D290	R:R:Y294	73.6576	8.05	Yes	Yes	2	9	9
45	R:R:Y294	R:R:Y295	65.4567	5.96	Yes	Yes	2	9	7
46	R:R:F52	R:R:Y295	28.496	5.16	No	Yes	2	7	7
47	R:R:F52	R:R:F67	28.9952	15	No	Yes	0	7	6
48	R:R:F67	R:R:L49	14.1411	4.87	Yes	No	0	6	7
49	R:R:F74	R:R:L49	12.1657	3.65	No	No	0	7	7
50	R:R:F301	R:R:Y295	34.0155	3.09	Yes	Yes	2	9	7
51	R:R:F301	R:R:I51	12.1015	7.54	Yes	Yes	2	9	7
52	R:R:F67	R:R:W59	11.9375	7.02	Yes	No	0	6	6
53	R:R:F180	R:R:F193	37.7523	8.57	Yes	Yes	1	3	6
54	R:R:E196	R:R:F193	66.8117	7	No	Yes	0	5	6
55	R:R:E196	R:R:I115	66.4194	4.1	No	Yes	0	5	8
56	R:R:I115	R:R:P200	100	3.39	Yes	No	0	8	9
57	R:R:P200	R:R:T119	95.5929	6.99	No	No	0	9	7
58	R:R:I203	R:R:T119	93.368	3.04	No	No	0	7	7
59	R:R:C207	R:R:I203	91.1289	1.64	No	No	0	8	7
60	R:R:C207	R:R:Y126	88.8754	9.41	No	Yes	0	8	7
61	R:R:F127	R:R:Y126	23.8679	5.16	Yes	Yes	3	5	7
62	R:R:F127	R:R:H134	16.095	7.92	Yes	Yes	3	5	4
63	R:R:H134	R:R:N137	10.7038	1.28	Yes	No	0	4	4
64	R:R:F244	R:R:I115	65.3569	8.79	Yes	Yes	2	8	8
65	L:L:?1	R:R:H189	26.0073	3.73	Yes	Yes	1	0	5
66	R:R:H189	R:R:M192	41.6031	3.94	Yes	Yes	0	5	5
67	R:R:M192	R:R:T159	18.1701	3.01	Yes	No	0	5	7
68	R:R:M109	R:R:T159	16.0522	3.01	Yes	No	0	5	7
69	R:R:M109	R:R:W152	26.4565	3.49	Yes	Yes	0	5	9
70	R:R:L76	R:R:Y284	34.6288	4.69	No	Yes	0	7	7
71	R:R:L76	R:R:N110	32.9601	5.49	No	Yes	0	7	9
72	R:R:M109	R:R:N110	28.2108	5.61	Yes	Yes	0	5	9
73	R:R:F95	R:R:W93	21.8855	10.02	Yes	Yes	0	7	9
74	R:R:M192	R:R:Q112	14.5261	5.44	Yes	No	0	5	7
75	R:R:L158	R:R:Q112	12.5152	6.65	No	No	0	5	7
76	R:R:F240	R:R:F244	23.3188	4.29	Yes	Yes	2	9	8
77	R:R:I154	R:R:L158	10.5755	1.43	No	No	0	5	5
78	R:R:I211	R:R:Y126	44.1917	2.42	No	Yes	0	8	7
79	R:R:I211	R:R:V129	26.3995	7.68	No	No	0	8	8
80	R:R:L215	R:R:V129	24.0605	4.47	No	No	0	8	8
81	R:R:M192	R:R:W188	10.1334	6.98	Yes	No	0	5	5
82	R:R:L258	R:R:Y269	12.3583	8.21	No	Yes	0	3	2
83	R:R:H184	R:R:L258	10.333	2.57	No	No	0	3	3
84	R:R:F197	R:R:F240	31.5268	6.43	Yes	Yes	0	8	9
85	R:R:F197	R:R:L201	14.6331	7.31	Yes	Yes	0	8	7
86	R:R:P246	R:R:T279	14.0198	5.25	No	Yes	0	9	7
87	R:R:L245	R:R:P246	13.0571	3.28	Yes	No	0	6	9
88	R:R:F197	R:R:L245	12.3725	3.65	Yes	Yes	0	8	6
89	R:R:I211	R:R:I233	16.0593	4.42	No	No	0	8	7
90	R:R:I212	R:R:I233	10.9534	2.94	No	No	0	5	7
91	R:R:I226	R:R:L215	16.0665	2.85	No	No	0	6	8
92	R:R:F301	R:R:S298	11.9019	2.64	Yes	No	0	9	8
93	R:R:F180	R:R:H189	20.3737	9.05	Yes	Yes	1	3	5
94	R:R:F240	R:R:I115	11.9803	3.77	Yes	Yes	2	9	8
95	R:R:F193	R:R:R251	24.9019	5.34	Yes	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	10.05	1	Yes	No	0	6	0	1
L:L:?1	R:R:N86	9.97	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y87	4.26	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W91	4.14	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L104	5.03	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	8.04	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	11.47	1	Yes	No	0	8	0	1
L:L:?1	R:R:S179	9.81	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	15.04	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	3.73	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F277	3.54	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	7.04	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	6.81	1	Yes	Yes	0	7	0	1
R:R:R22	R:R:W91	5	0	No	Yes	3	4	2	1
R:R:I26	R:R:Y87	3.63	1	Yes	Yes	5	6	2	1
R:R:I26	R:R:W91	5.87	1	Yes	Yes	5	4	2	1
R:R:F277	R:R:I26	3.77	1	Yes	Yes	5	5	1	2
R:R:L30	R:R:L34	4.15	1	Yes	No	5	8	2	2
R:R:L30	R:R:Y87	9.38	1	Yes	Yes	5	6	2	1
R:R:L34	R:R:Y87	3.52	1	No	Yes	8	6	2	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	4.69	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	No	6	6	2	1
R:R:N86	R:R:W91	7.91	1	No	Yes	5	4	1	1
R:R:N86	R:R:W93	5.65	1	No	Yes	5	9	1	2
R:R:W91	R:R:Y87	6.75	1	Yes	Yes	4	6	1	1
R:R:F277	R:R:W91	8.02	1	Yes	Yes	5	4	1	1
R:R:L104	R:R:S179	6.01	1	No	No	5	4	1	1
R:R:L107	R:R:Y284	3.52	1	No	Yes	6	7	1	1
R:R:H189	R:R:S179	5.58	1	Yes	No	5	4	1	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	1	1
R:R:E190	R:R:F180	5.83	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	8.57	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	3.21	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	4.29	1	Yes	Yes	3	4	1	2
R:R:H189	R:R:Q187	3.71	1	Yes	No	5	2	1	2
R:R:E190	R:R:Q187	10.19	1	Yes	No	4	2	2	2
R:R:H189	R:R:M192	3.94	1	Yes	Yes	5	5	1	2
R:R:E190	R:R:R251	11.63	1	Yes	Yes	4	5	2	2
R:R:F193	R:R:R251	5.34	1	Yes	Yes	6	5	2	2
R:R:F193	R:R:F276	3.22	1	Yes	Yes	6	4	2	2
R:R:F276	R:R:R251	10.69	1	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	3.65	1	Yes	No	4	5	2	1
R:R:S281	R:R:Y284	3.82	0	No	Yes	6	7	2	1
R:R:T283	R:R:Y284	6.24	0	No	Yes	8	7	2	1
R:R:F180	R:R:S178	1.32	1	Yes	No	3	4	1	2
R:R:F277	R:R:S178	1.32	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	276
Number of Links	320
Number of Hubs	43
Number of Links mediated by Hubs	167
Number of Communities	7
Number of Nodes involved in Communities	60
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	47843
Length Of Smallest Path	3
Average Path Length	12.6134
Length of Longest Path	27
Minimum Path Strength	1.295
Average Path Strength	5.67963
Maximum Path Strength	13.975
Minimum Path Correlation	0.7
Average Path Correlation	0.919956
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.4246
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.1653
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9IZA_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

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