psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L83	7.23	Yes	No	0	0	6
2	L:L:?1	R:R:N86	7.17	Yes	No	0	0	5
3	L:L:?1	R:R:Y87	3.06	Yes	Yes	1	0	6
4	L:L:?1	R:R:L104	3.61	Yes	No	1	0	5
5	L:L:?1	R:R:L107	5.78	Yes	No	1	0	6
6	L:L:?1	R:R:R111	8.25	Yes	No	0	0	8
7	L:L:?1	R:R:S179	7.06	Yes	No	1	0	4
8	L:L:?1	R:R:F180	10.81	Yes	Yes	1	0	3
9	L:L:?1	R:R:L280	5.06	Yes	No	0	0	5
10	L:L:?1	R:R:Y284	4.9	Yes	Yes	1	0	7
11	R:R:F21	R:R:H9	18.1	Yes	No	0	2	6
12	R:R:E267	R:R:H9	9.85	No	No	0	2	6
13	R:R:F10	R:R:N17	12.08	No	No	4	7	5
14	R:R:F10	R:R:T263	3.89	No	Yes	4	7	3
15	R:R:E12	R:R:L11	3.98	No	No	0	5	8
16	R:R:I13	R:R:L11	5.71	No	No	0	3	8
17	R:R:L11	R:R:N171	9.61	No	No	0	8	1
18	R:R:C18	R:R:I13	6.55	No	No	0	9	3
19	R:R:I13	R:R:S181	3.1	No	No	0	3	4
20	R:R:D14	R:R:K15	5.53	No	No	0	5	3
21	R:R:N17	R:R:T263	5.85	No	Yes	4	5	3
22	R:R:C18	R:R:C183	7.28	No	No	0	9	1
23	R:R:C19	R:R:C266	7.28	No	No	4	4	7
24	R:R:N171	R:R:V20	4.43	No	No	0	1	2
25	R:R:L176	R:R:V20	4.47	No	No	0	4	2
26	R:R:S181	R:R:V20	3.23	No	No	0	4	2
27	R:R:C266	R:R:F21	4.19	No	Yes	0	7	2
28	R:R:F21	R:R:R270	6.41	Yes	No	0	2	1
29	R:R:D273	R:R:F21	8.36	No	Yes	0	4	2
30	R:R:R22	R:R:R90	12.79	No	No	0	3	4
31	R:R:R22	R:R:W91	5	No	Yes	0	3	4
32	R:R:A174	R:R:R22	4.15	No	No	0	2	3
33	R:R:D23	R:R:D24	7.98	No	No	0	4	4
34	R:R:D23	R:R:F25	4.78	No	No	0	4	6
35	R:R:I26	R:R:Y87	3.63	Yes	Yes	1	5	6
36	R:R:I26	R:R:W91	5.87	Yes	Yes	1	5	4
37	R:R:I26	R:R:L274	4.28	Yes	No	0	5	1
38	R:R:F277	R:R:I26	3.77	No	Yes	1	5	5
39	R:R:L30	R:R:L34	4.15	Yes	No	1	5	8
40	R:R:L30	R:R:Y87	9.38	Yes	Yes	1	5	6
41	R:R:I278	R:R:L30	4.28	No	Yes	0	6	5
42	R:R:P31	R:R:P32	5.84	No	No	0	6	5
43	R:R:L34	R:R:Y87	3.52	No	Yes	1	8	6
44	R:R:G35	R:R:M84	3.49	No	No	0	5	7
45	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
46	R:R:F38	R:R:L42	13.4	No	No	0	7	7
47	R:R:F38	R:R:L80	4.87	No	No	0	7	8
48	R:R:F38	R:R:P81	5.78	No	No	0	7	8
49	R:R:F40	R:R:M288	4.98	No	No	0	6	8
50	R:R:G44	R:R:P291	4.06	No	No	0	7	9
51	R:R:F74	R:R:N45	4.83	No	No	0	7	9
52	R:R:N45	R:R:P291	4.89	No	No	0	9	9
53	R:R:I51	R:R:L47	4.28	Yes	No	0	7	6
54	R:R:F296	R:R:L47	6.09	No	No	0	8	6
55	R:R:A48	R:R:F296	4.16	No	No	0	9	8
56	R:R:F67	R:R:L49	4.87	Yes	No	0	6	7
57	R:R:F74	R:R:L49	3.65	No	No	0	7	7
58	R:R:I51	R:R:L56	4.28	Yes	No	2	7	5
59	R:R:F301	R:R:I51	7.54	Yes	Yes	2	9	7
60	R:R:F52	R:R:F67	15	No	Yes	0	7	6
61	R:R:F52	R:R:Y295	5.16	No	Yes	2	7	7
62	R:R:F301	R:R:F52	7.5	Yes	No	2	9	7
63	R:R:F54	R:R:H55	3.39	No	No	0	4	5
64	R:R:L56	R:R:R63	6.07	No	No	2	5	7
65	R:R:F301	R:R:L56	8.53	Yes	No	2	9	5
66	R:R:R63	R:R:S58	3.95	No	No	0	7	6
67	R:R:I64	R:R:W59	4.7	No	No	0	7	6
68	R:R:F67	R:R:W59	7.02	Yes	No	0	6	6
69	R:R:I139	R:R:S61	7.74	No	No	0	7	6
70	R:R:A144	R:R:S61	3.42	No	No	0	7	6
71	R:R:R128	R:R:S62	5.27	No	No	0	8	8
72	R:R:F301	R:R:R63	3.21	Yes	No	2	9	7
73	R:R:I64	R:R:N141	4.25	No	No	0	7	2
74	R:R:A144	R:R:I64	4.87	No	No	0	7	7
75	R:R:F65	R:R:V120	9.18	No	No	0	7	7
76	R:R:L66	R:R:Y294	4.69	No	Yes	2	8	9
77	R:R:L66	R:R:Y295	7.03	No	Yes	2	8	7
78	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
79	R:R:F117	R:R:N68	15.71	No	No	5	8	9
80	R:R:N68	R:R:S148	8.94	No	No	0	9	8
81	R:R:N68	R:R:W152	5.65	No	Yes	5	9	9
82	R:R:D73	R:R:L69	5.43	No	No	2	9	9
83	R:R:D290	R:R:L69	4.07	Yes	No	2	9	9
84	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
85	R:R:D73	R:R:S287	10.31	No	No	0	9	8
86	R:R:D290	R:R:D73	6.65	Yes	No	2	9	9
87	R:R:F74	R:R:I78	10.05	No	No	0	7	6
88	R:R:L75	R:R:N110	5.49	No	Yes	0	6	9
89	R:R:L76	R:R:N110	5.49	No	Yes	0	7	9
90	R:R:L76	R:R:Y284	4.69	No	Yes	0	7	7
91	R:R:I77	R:R:L80	4.28	No	No	0	6	8
92	R:R:I77	R:R:S287	6.19	No	No	0	6	8
93	R:R:C79	R:R:L107	3.17	No	No	0	6	6
94	R:R:F82	R:R:F95	6.43	No	Yes	0	6	7
95	R:R:F82	R:R:M103	3.73	No	No	0	6	5
96	R:R:D85	R:R:R89	5.96	No	No	0	4	4
97	R:R:D85	R:R:F95	4.78	No	Yes	0	4	7
98	R:R:N86	R:R:W91	7.91	No	Yes	0	5	4
99	R:R:N86	R:R:W93	5.65	No	Yes	0	5	9
100	R:R:W91	R:R:Y87	6.75	Yes	Yes	1	4	6
101	R:R:K94	R:R:R89	8.66	No	No	0	3	4
102	R:R:F277	R:R:W91	8.02	No	Yes	1	5	4
103	R:R:D92	R:R:K94	6.91	No	No	0	4	3
104	R:R:A174	R:R:D92	3.09	No	No	0	2	4
105	R:R:F95	R:R:W93	10.02	Yes	Yes	0	7	9
106	R:R:C100	R:R:W93	6.53	Yes	Yes	6	9	9
107	R:R:C177	R:R:W93	14.37	No	Yes	6	9	9
108	R:R:F95	R:R:P99	7.22	Yes	No	0	7	5
109	R:R:G96	R:R:P99	4.06	No	No	0	7	5
110	R:R:D97	R:R:K166	5.53	No	No	0	3	4
111	R:R:D97	R:R:P168	12.88	No	No	0	3	4
112	R:R:I98	R:R:P99	3.39	No	No	0	2	5
113	R:R:I98	R:R:R101	7.52	No	No	0	2	6
114	R:R:C100	R:R:M167	4.86	Yes	No	0	9	3
115	R:R:C100	R:R:P168	3.77	Yes	No	0	9	4
116	R:R:C100	R:R:C177	7.28	Yes	No	6	9	9
117	R:R:L163	R:R:R101	10.93	No	No	0	5	6
118	R:R:L104	R:R:S179	6.01	No	No	1	5	4
119	R:R:F105	R:R:M109	8.71	No	Yes	0	6	5
120	R:R:F105	R:R:L163	7.31	No	No	0	6	5
121	R:R:M106	R:R:N110	8.41	No	Yes	0	5	9
122	R:R:L107	R:R:Y284	3.52	No	Yes	1	6	7
123	R:R:A108	R:R:T159	3.36	No	No	0	4	7
124	R:R:M109	R:R:N110	5.61	Yes	Yes	0	5	9
125	R:R:M109	R:R:W152	3.49	Yes	Yes	0	5	9
126	R:R:I156	R:R:M109	5.83	No	Yes	0	4	5
127	R:R:L158	R:R:Q112	6.65	No	No	0	5	7
128	R:R:M192	R:R:Q112	5.44	Yes	No	0	5	7
129	R:R:G113	R:R:T155	3.64	No	No	0	7	7
130	R:R:I115	R:R:S114	3.1	Yes	No	0	8	9
131	R:R:E196	R:R:I115	4.1	No	Yes	0	5	8
132	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
133	R:R:F240	R:R:I115	3.77	Yes	Yes	2	9	8
134	R:R:F244	R:R:I115	8.79	Yes	Yes	2	8	8
135	R:R:I116	R:R:L151	4.28	No	Yes	0	5	7
136	R:R:F117	R:R:W152	11.02	No	Yes	5	8	9
137	R:R:F240	R:R:L118	3.65	Yes	No	0	9	9
138	R:R:P200	R:R:T119	6.99	No	No	0	9	7
139	R:R:I203	R:R:T119	3.04	No	No	0	7	7
140	R:R:R125	R:R:V121	5.23	No	No	0	9	9
141	R:R:D124	R:R:R128	9.53	No	No	0	8	8
142	R:R:R125	R:R:Y294	4.12	No	Yes	0	9	9
143	R:R:F127	R:R:Y126	5.16	Yes	Yes	3	5	7
144	R:R:V130	R:R:Y126	12.62	Yes	Yes	3	8	7
145	R:R:H131	R:R:Y126	6.53	Yes	Yes	3	7	7
146	R:R:F206	R:R:Y126	4.13	No	Yes	3	4	7
147	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
148	R:R:R210	R:R:Y126	7.2	Yes	Yes	3	4	7
149	R:R:F127	R:R:H131	3.39	Yes	Yes	3	5	7
150	R:R:F127	R:R:H134	7.92	Yes	Yes	3	5	4
151	R:R:F127	R:R:L136	4.87	Yes	No	3	5	4
152	R:R:N137	R:R:R128	6.03	No	No	0	4	8
153	R:R:I211	R:R:V129	7.68	No	No	0	8	8
154	R:R:L215	R:R:V129	4.47	No	No	0	8	8
155	R:R:H131	R:R:V130	4.15	Yes	Yes	3	7	8
156	R:R:R210	R:R:V130	3.92	Yes	Yes	3	4	8
157	R:R:S214	R:R:V130	4.85	No	Yes	0	5	8
158	R:R:H134	R:R:L136	6.43	Yes	No	3	4	4
159	R:R:S140	R:R:T143	4.8	No	No	0	6	3
160	R:R:A145	R:R:R142	4.15	No	No	0	3	4
161	R:R:I147	R:R:T143	3.04	No	No	0	5	3
162	R:R:I154	R:R:L150	4.28	No	No	0	5	4
163	R:R:T155	R:R:W152	3.64	No	Yes	0	7	9
164	R:R:H161	R:R:L162	9	No	No	0	7	4
165	R:R:H161	R:R:W188	3.17	No	No	0	7	5
166	R:R:I169	R:R:L176	7.14	No	No	0	1	4
167	R:R:H189	R:R:S179	5.58	Yes	No	0	5	4
168	R:R:F180	R:R:H189	9.05	Yes	Yes	0	3	5
169	R:R:E190	R:R:F180	5.83	Yes	Yes	1	4	3
170	R:R:F180	R:R:F193	8.57	Yes	Yes	1	3	6
171	R:R:F180	R:R:R251	3.21	Yes	Yes	1	3	5
172	R:R:F180	R:R:F276	4.29	Yes	Yes	1	3	4
173	R:R:C183	R:R:S181	3.44	No	No	0	1	4
174	R:R:I182	R:R:Y269	6.04	No	Yes	0	3	2
175	R:R:D273	R:R:I182	5.6	No	No	0	4	3
176	R:R:G262	R:R:H184	3.18	No	No	0	4	3
177	R:R:A191	R:R:F186	4.16	No	No	0	3	4
178	R:R:H189	R:R:Q187	3.71	Yes	No	0	5	2
179	R:R:E190	R:R:Q187	10.19	Yes	No	0	4	2
180	R:R:M192	R:R:W188	6.98	Yes	No	0	5	5
181	R:R:H189	R:R:M192	3.94	Yes	Yes	0	5	5
182	R:R:E190	R:R:R251	11.63	Yes	Yes	1	4	5
183	R:R:E190	R:R:F255	4.66	Yes	No	1	4	5
184	R:R:E196	R:R:F193	7	No	Yes	0	5	6
185	R:R:F193	R:R:R251	5.34	Yes	Yes	1	6	5
186	R:R:F193	R:R:F276	3.22	Yes	Yes	1	6	4
187	R:R:I252	R:R:L194	4.28	No	No	0	6	4
188	R:R:F197	R:R:F198	7.5	Yes	No	0	8	5
189	R:R:F197	R:R:L201	7.31	Yes	Yes	0	8	7
190	R:R:F197	R:R:F240	6.43	Yes	Yes	0	8	9
191	R:R:F197	R:R:L245	3.65	Yes	Yes	0	8	6
192	R:R:F197	R:R:V248	9.18	Yes	No	0	8	8
193	R:R:F206	R:R:R210	6.41	No	Yes	3	4	4
194	R:R:I233	R:R:S208	3.1	No	No	0	7	8
195	R:R:R210	R:R:W213	5	Yes	No	0	4	3
196	R:R:I211	R:R:I233	4.42	No	No	0	8	7
197	R:R:I212	R:R:I230	7.36	No	No	8	5	6
198	R:R:S214	R:R:W213	7.41	No	No	0	5	3
199	R:R:Q217	R:R:W213	13.14	No	No	0	5	3
200	R:R:M220	R:R:R218	6.2	No	No	0	3	5
201	R:R:D221	R:R:K227	6.91	No	No	0	3	4
202	R:R:H223	R:R:K225	13.1	No	No	0	4	5
203	R:R:P299	R:R:R228	7.21	No	No	0	5	7
204	R:R:F232	R:R:S297	6.61	No	No	0	7	6
205	R:R:V236	R:R:Y294	6.31	No	Yes	0	8	9
206	R:R:F240	R:R:F244	4.29	Yes	Yes	2	9	8
207	R:R:C243	R:R:F244	4.19	No	Yes	2	8	8
208	R:R:C243	R:R:N286	9.45	No	No	2	8	9
209	R:R:F244	R:R:T283	6.49	Yes	No	0	8	8
210	R:R:F244	R:R:N286	12.08	Yes	No	2	8	9
211	R:R:L245	R:R:P246	3.28	Yes	No	0	6	9
212	R:R:P246	R:R:T279	5.25	No	Yes	0	9	7
213	R:R:S247	R:R:T279	4.8	No	Yes	0	6	7
214	R:R:F276	R:R:V250	6.55	Yes	No	0	4	5
215	R:R:T279	R:R:V250	3.17	Yes	No	0	7	5
216	R:R:I254	R:R:R251	8.77	No	Yes	0	4	5
217	R:R:F255	R:R:R251	6.41	No	Yes	1	5	5
218	R:R:F276	R:R:R251	10.69	Yes	Yes	1	4	5
219	R:R:I254	R:R:V272	4.61	No	No	0	4	4
220	R:R:L257	R:R:V268	5.96	No	No	7	3	1
221	R:R:L257	R:R:Y269	5.86	No	Yes	7	3	2
222	R:R:L258	R:R:Y269	8.21	No	Yes	0	3	2
223	R:R:S261	R:R:T260	3.2	No	No	0	3	1
224	R:R:E267	R:R:R270	16.28	No	No	0	2	1
225	R:R:V268	R:R:Y269	5.05	No	Yes	7	1	2
226	R:R:F276	R:R:L280	3.65	Yes	No	0	4	5
227	R:R:F282	R:R:T279	3.89	No	Yes	0	7	7
228	R:R:S281	R:R:Y284	3.82	No	Yes	0	6	7
229	R:R:F282	R:R:M285	4.98	No	No	0	7	5
230	R:R:T283	R:R:Y284	6.24	No	Yes	0	8	7
231	R:R:D290	R:R:N286	5.39	Yes	No	2	9	9
232	R:R:D290	R:R:Y294	8.05	Yes	Yes	2	9	9
233	R:R:V293	R:R:Y294	3.79	No	Yes	0	8	9
234	R:R:Y294	R:R:Y295	5.96	Yes	Yes	2	9	7
235	R:R:F301	R:R:Y295	3.09	Yes	Yes	2	9	7
236	R:R:F296	R:R:F301	3.22	No	Yes	0	8	9
237	R:R:P299	R:R:S298	3.56	No	No	0	5	8
238	R:R:S298	R:R:S300	3.26	No	No	0	8	5
239	R:R:F54	R:R:W50	3.01	No	No	0	4	4
240	R:R:M109	R:R:T159	3.01	Yes	No	0	5	7
241	R:R:M192	R:R:T159	3.01	Yes	No	0	5	7
242	R:R:K16	R:R:T185	3	No	No	0	4	2
243	R:R:L245	R:R:V249	2.98	Yes	No	0	6	6
244	R:R:I212	R:R:I233	2.94	No	No	0	5	7
245	R:R:I238	R:R:I242	2.94	No	No	0	5	5
246	R:R:I169	R:R:M167	2.92	No	No	0	1	3
247	R:R:I212	R:R:M234	2.92	No	No	8	5	4
248	R:R:I230	R:R:M234	2.92	No	No	8	6	4
249	R:R:M285	R:R:M288	2.89	No	No	0	5	8
250	R:R:I147	R:R:L151	2.85	No	Yes	0	5	7
251	R:R:I226	R:R:L215	2.85	No	No	0	6	8
252	R:R:Q187	R:R:T185	2.83	No	No	0	2	2
253	R:R:L215	R:R:M220	2.83	No	No	0	8	3
254	R:R:L289	R:R:M285	2.83	No	No	0	7	5
255	R:R:D23	R:R:I26	2.8	No	Yes	0	4	5
256	R:R:C53	R:R:F54	2.79	No	No	0	4	4
257	R:R:L201	R:R:L205	2.77	Yes	No	0	7	4
258	R:R:F65	R:R:S148	2.64	No	No	0	7	8
259	R:R:F301	R:R:S298	2.64	Yes	No	0	9	8
260	R:R:F25	R:R:V29	2.62	No	No	0	6	5
261	R:R:R90	R:R:V27	2.62	No	No	0	4	3
262	R:R:R89	R:R:V88	2.62	No	No	0	4	3
263	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
264	R:R:R253	R:R:V272	2.62	No	No	0	5	4
265	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
266	R:R:A191	R:R:W188	2.59	No	No	0	3	5
267	R:R:H184	R:R:L258	2.57	No	No	0	3	3
268	R:R:F117	R:R:L151	2.44	No	Yes	0	8	7
269	R:R:F255	R:R:L194	2.44	No	No	0	5	4
270	R:R:T260	R:R:W256	2.43	No	No	0	1	4
271	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	7
272	R:R:F232	R:R:R228	2.14	No	No	0	7	7
273	R:R:G172	R:R:G173	2.11	No	No	0	3	4
274	R:R:G262	R:R:S261	1.86	No	No	0	4	3
275	R:R:G41	R:R:I77	1.76	No	No	0	8	6
276	R:R:G153	R:R:I156	1.76	No	No	0	4	4
277	R:R:G157	R:R:I156	1.76	No	No	0	5	4
278	R:R:G35	R:R:L34	1.71	No	No	0	5	8
279	R:R:G44	R:R:L43	1.71	No	No	0	7	4
280	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
281	R:R:C243	R:R:V239	1.71	No	No	0	8	7
282	R:R:G172	R:R:N171	1.7	No	No	0	3	1
283	R:R:C19	R:R:T263	1.69	No	Yes	4	4	3
284	R:R:C266	R:R:T263	1.69	No	Yes	4	7	3
285	R:R:L30	R:R:P31	1.64	Yes	No	0	5	6
286	R:R:G173	R:R:Q170	1.64	No	No	0	4	1
287	R:R:L199	R:R:P200	1.64	No	No	0	4	9
288	R:R:C207	R:R:I203	1.64	No	No	0	8	7
289	R:R:S281	R:R:V33	1.62	No	No	0	6	5
290	R:R:A122	R:R:I204	1.62	No	No	0	9	8
291	R:R:A237	R:R:I204	1.62	No	No	0	7	8
292	R:R:V235	R:R:V239	1.6	No	No	0	5	7
293	R:R:V235	R:R:V293	1.6	No	No	0	5	8
294	R:R:A237	R:R:L205	1.58	No	No	0	7	4
295	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
296	R:R:H133	R:R:P132	1.53	No	No	0	6	8
297	R:R:M234	R:R:T231	1.51	No	No	0	4	6
298	R:R:L163	R:R:V160	1.49	No	No	0	5	4
299	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
300	R:R:L245	R:R:V241	1.49	Yes	No	0	6	5
301	R:R:A135	R:R:H134	1.46	No	Yes	0	5	4
302	R:R:I39	R:R:L42	1.43	No	No	0	5	7
303	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
304	R:R:I154	R:R:L158	1.43	No	No	0	5	5
305	R:R:D221	R:R:I226	1.4	No	No	0	3	6
306	R:R:D24	R:R:K28	1.38	No	No	0	4	3
307	R:R:H55	R:R:I51	1.33	No	Yes	0	5	7
308	R:R:H223	R:R:I226	1.33	No	No	0	4	6
309	R:R:F180	R:R:S178	1.32	Yes	No	0	3	4
310	R:R:F277	R:R:S178	1.32	No	No	0	5	4
311	R:R:N265	R:R:Q264	1.32	No	No	0	5	3
312	R:R:H134	R:R:N137	1.28	Yes	No	0	4	4
313	R:R:V272	R:R:Y269	1.26	No	Yes	0	4	2
314	R:R:I146	R:R:R142	1.25	No	No	0	3	4
315	R:R:F40	R:R:L36	1.22	No	No	0	6	4
316	R:R:D221	R:R:R216	1.19	No	No	0	3	4
317	R:R:N175	R:R:W93	1.13	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.293	10	1	0
2	R:R:F21	9.265	4	0	2
3	R:R:I26	4.07	5	1	5
4	R:R:L30	4.8625	4	1	5
5	R:R:I51	4.3575	4	2	7
6	R:R:F67	8.69	4	0	6
7	R:R:Y87	5.268	5	1	6
8	R:R:W91	6.71	5	1	4
9	R:R:W93	7.54	5	6	9
10	R:R:F95	7.1125	4	0	7
11	R:R:C100	5.61	4	6	9
12	R:R:M109	5.33	5	0	5
13	R:R:N110	6.25	4	0	9
14	R:R:I115	4.63	5	2	8
15	R:R:Y126	6.78143	7	3	7
16	R:R:F127	4.792	5	3	5
17	R:R:V130	6.385	4	3	8
18	R:R:H131	3.9	4	3	7
19	R:R:H134	4.2725	4	3	4
20	R:R:L151	2.75	4	0	7
21	R:R:W152	5.278	5	5	9
22	R:R:F180	6.15429	7	1	3
23	R:R:H189	5.57	4	0	5
24	R:R:E190	8.0775	4	1	4
25	R:R:M192	4.8425	4	0	5
26	R:R:F193	6.0325	4	1	6
27	R:R:F197	6.814	5	0	8
28	R:R:L201	3.32	4	0	7
29	R:R:R210	5.6325	4	3	4
30	R:R:F240	4.535	4	2	9
31	R:R:F244	7.168	5	2	8
32	R:R:L245	2.85	4	0	6
33	R:R:R251	7.675	6	1	5
34	R:R:T263	3.28	4	4	3
35	R:R:Y269	5.284	5	7	2
36	R:R:F276	5.68	5	1	4
37	R:R:T279	4.2775	4	0	7
38	R:R:Y284	4.42333	6	1	7
39	R:R:D290	6.04	4	2	9
40	R:R:Y294	5.48667	6	2	9
41	R:R:Y295	5.048	5	2	7
42	R:R:F301	5.10429	7	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F180	65.8657	10.81	Yes	Yes	1	0	3
2	R:R:F180	R:R:R251	25.3448	3.21	Yes	Yes	1	3	5
3	R:R:I254	R:R:R251	44.9993	8.77	No	Yes	0	4	5
4	R:R:I254	R:R:V272	43.272	4.61	No	No	0	4	4
5	R:R:V272	R:R:Y269	39.7757	1.26	No	Yes	0	4	2
6	R:R:I182	R:R:Y269	23.3459	6.04	No	Yes	0	3	2
7	R:R:D273	R:R:I182	21.4375	5.6	No	No	0	4	3
8	R:R:D273	R:R:F21	19.5292	8.36	No	Yes	0	4	2
9	R:R:C266	R:R:F21	10.078	4.19	No	Yes	0	7	2
10	L:L:?1	R:R:N86	84.5034	7.17	Yes	No	0	0	5
11	R:R:N86	R:R:W93	72.9628	5.65	No	Yes	0	5	9
12	R:R:C100	R:R:W93	46.4758	6.53	Yes	Yes	6	9	9
13	R:R:C100	R:R:M167	37.1361	4.86	Yes	No	0	9	3
14	R:R:I169	R:R:M167	34.7332	2.92	No	No	0	1	3
15	R:R:I169	R:R:L176	32.3165	7.14	No	No	0	1	4
16	R:R:L176	R:R:V20	29.8788	4.47	No	No	0	4	2
17	R:R:N171	R:R:V20	15.218	4.43	No	No	0	1	2
18	R:R:S181	R:R:V20	12.4878	3.23	No	No	0	4	2
19	R:R:N86	R:R:W91	20.3998	7.91	No	Yes	0	5	4
20	R:R:R22	R:R:W91	31.9613	5	No	Yes	0	3	4
21	L:L:?1	R:R:Y87	48.7881	3.06	Yes	Yes	1	0	6
22	R:R:W91	R:R:Y87	17.5094	6.75	Yes	Yes	1	4	6
23	R:R:R22	R:R:R90	10.9138	12.79	No	No	0	3	4
24	R:R:A174	R:R:R22	15.8518	4.15	No	No	0	2	3
25	R:R:I26	R:R:Y87	15.8796	3.63	Yes	Yes	1	5	6
26	R:R:D23	R:R:I26	16.6736	2.8	No	Yes	0	4	5
27	R:R:L30	R:R:Y87	10.9974	9.38	Yes	Yes	1	5	6
28	L:L:?1	R:R:Y284	85.7849	4.9	Yes	Yes	1	0	7
29	R:R:T283	R:R:Y284	98.8021	6.24	No	Yes	0	8	7
30	R:R:F244	R:R:T283	98.3493	6.49	Yes	No	0	8	8
31	R:R:F244	R:R:N286	100	12.08	Yes	No	2	8	9
32	R:R:D290	R:R:N286	98.9553	5.39	Yes	No	2	9	9
33	R:R:D290	R:R:D73	19.8008	6.65	Yes	No	2	9	9
34	R:R:D73	R:R:S287	17.7114	10.31	No	No	0	9	8
35	R:R:I77	R:R:S287	15.5453	6.19	No	No	0	6	8
36	R:R:I77	R:R:L80	11.1715	4.28	No	No	0	6	8
37	R:R:F180	R:R:F276	12.9893	4.29	Yes	Yes	1	3	4
38	R:R:F276	R:R:V250	25.4353	6.55	Yes	No	0	4	5
39	R:R:T279	R:R:V250	23.1369	3.17	Yes	No	0	7	5
40	R:R:F282	R:R:T279	17.7532	3.89	No	Yes	0	7	7
41	R:R:F282	R:R:M285	14.828	4.98	No	No	0	7	5
42	R:R:D290	R:R:Y294	81.5643	8.05	Yes	Yes	2	9	9
43	R:R:Y294	R:R:Y295	72.3569	5.96	Yes	Yes	2	9	7
44	R:R:F52	R:R:Y295	31.4529	5.16	No	Yes	2	7	7
45	R:R:F52	R:R:F67	31.7593	15	No	Yes	0	7	6
46	R:R:F67	R:R:L49	15.4687	4.87	Yes	No	0	6	7
47	R:R:F74	R:R:L49	13.3027	3.65	No	No	0	7	7
48	R:R:F301	R:R:Y295	37.554	3.09	Yes	Yes	2	9	7
49	R:R:F301	R:R:I51	13.24	7.54	Yes	Yes	2	9	7
50	R:R:F67	R:R:W59	13.0241	7.02	Yes	No	0	6	6
51	R:R:I64	R:R:W59	10.8302	4.7	No	No	0	7	6
52	R:R:F180	R:R:F193	44.261	8.57	Yes	Yes	1	3	6
53	R:R:E196	R:R:F193	73.8055	7	No	Yes	0	5	6
54	R:R:E196	R:R:I115	73.4225	4.1	No	Yes	0	5	8
55	R:R:I115	R:R:P200	95.8769	3.39	Yes	No	0	8	9
56	R:R:P200	R:R:T119	91.6702	6.99	No	No	0	9	7
57	R:R:I203	R:R:T119	89.5459	3.04	No	No	0	7	7
58	R:R:C207	R:R:I203	87.4077	1.64	No	No	0	8	7
59	R:R:C207	R:R:Y126	85.2556	9.41	No	Yes	0	8	7
60	R:R:F127	R:R:Y126	22.9071	5.16	Yes	Yes	3	5	7
61	R:R:F127	R:R:H134	15.4618	7.92	Yes	Yes	3	5	4
62	R:R:H134	R:R:N137	10.2939	1.28	Yes	No	0	4	4
63	R:R:F244	R:R:I115	70.2535	8.79	Yes	Yes	2	8	8
64	R:R:L76	R:R:Y284	35.2347	4.69	No	Yes	0	7	7
65	R:R:L76	R:R:N110	33.6398	5.49	No	Yes	0	7	9
66	R:R:M109	R:R:N110	29.1684	5.61	Yes	Yes	0	5	9
67	R:R:M109	R:R:W152	24.3	3.49	Yes	Yes	0	5	9
68	R:R:F117	R:R:W152	10.2034	11.02	No	Yes	5	8	9
69	R:R:F95	R:R:W93	23.9866	10.02	Yes	Yes	0	7	9
70	R:R:D85	R:R:F95	10.0293	4.78	No	Yes	0	4	7
71	R:R:A174	R:R:D92	10.5238	3.09	No	No	0	2	4
72	L:L:?1	R:R:S179	17.1472	7.06	Yes	No	1	0	4
73	R:R:H189	R:R:S179	16.3324	5.58	Yes	No	0	5	4
74	R:R:H189	R:R:M192	48.6419	3.94	Yes	Yes	0	5	5
75	R:R:M192	R:R:T159	11.4779	3.01	Yes	No	0	5	7
76	R:R:F180	R:R:H189	43.1606	9.05	Yes	Yes	0	3	5
77	R:R:M192	R:R:Q112	21.152	5.44	Yes	No	0	5	7
78	R:R:L158	R:R:Q112	17.8646	6.65	No	No	0	5	7
79	R:R:F240	R:R:F244	20.8177	4.29	Yes	Yes	2	9	8
80	R:R:I154	R:R:L158	14.6469	1.43	No	No	0	5	5
81	R:R:I211	R:R:Y126	42.4363	2.42	No	Yes	0	8	7
82	R:R:I211	R:R:V129	25.3657	7.68	No	No	0	8	8
83	R:R:L215	R:R:V129	23.0951	4.47	No	No	0	8	8
84	R:R:M192	R:R:W188	16.1095	6.98	Yes	No	0	5	5
85	R:R:L258	R:R:Y269	12.0699	8.21	No	Yes	0	3	2
86	R:R:H184	R:R:L258	10.0919	2.57	No	No	0	3	3
87	R:R:H189	R:R:Q187	10.4959	3.71	Yes	No	0	5	2
88	R:R:E190	R:R:F180	10.3427	5.83	Yes	Yes	1	4	3
89	R:R:F197	R:R:F240	29.2172	6.43	Yes	Yes	0	8	9
90	R:R:F197	R:R:L201	13.3236	7.31	Yes	Yes	0	8	7
91	R:R:P246	R:R:T279	13.4977	5.25	No	Yes	0	9	7
92	R:R:L245	R:R:P246	12.6062	3.28	Yes	No	0	6	9
93	R:R:F197	R:R:L245	11.9376	3.65	Yes	Yes	0	8	6
94	R:R:I211	R:R:I233	15.4269	4.42	No	No	0	8	7
95	R:R:I212	R:R:I233	10.5029	2.94	No	No	0	5	7
96	R:R:I226	R:R:L215	15.4339	2.85	No	No	0	6	8
97	R:R:F301	R:R:S298	12.9893	2.64	Yes	No	0	9	8
98	R:R:Q187	R:R:T185	12.5296	2.83	No	No	0	2	2
99	R:R:F277	R:R:S178	13.0729	1.32	No	No	0	5	4
100	R:R:F180	R:R:S178	14.5355	1.32	Yes	No	0	3	4
101	R:R:F240	R:R:I115	11.7774	3.77	Yes	Yes	2	9	8
102	R:R:F193	R:R:R251	25.498	5.34	Yes	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	7.23	1	Yes	No	0	6	0	1
L:L:?1	R:R:N86	7.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y87	3.06	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L104	3.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	5.78	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	8.25	1	Yes	No	0	8	0	1
L:L:?1	R:R:S179	7.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	10.81	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:L280	5.06	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	4.9	1	Yes	Yes	0	7	0	1
R:R:I26	R:R:Y87	3.63	1	Yes	Yes	5	6	2	1
R:R:I26	R:R:W91	5.87	1	Yes	Yes	5	4	2	2
R:R:L30	R:R:L34	4.15	1	Yes	No	5	8	2	2
R:R:L30	R:R:Y87	9.38	1	Yes	Yes	5	6	2	1
R:R:L34	R:R:Y87	3.52	1	No	Yes	8	6	2	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	4.69	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	No	6	6	2	1
R:R:N86	R:R:W91	7.91	0	No	Yes	5	4	1	2
R:R:N86	R:R:W93	5.65	0	No	Yes	5	9	1	2
R:R:W91	R:R:Y87	6.75	1	Yes	Yes	4	6	2	1
R:R:L104	R:R:S179	6.01	1	No	No	5	4	1	1
R:R:L107	R:R:Y284	3.52	1	No	Yes	6	7	1	1
R:R:H189	R:R:S179	5.58	0	Yes	No	5	4	2	1
R:R:F180	R:R:H189	9.05	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	5.83	1	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	8.57	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	3.21	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	4.29	1	Yes	Yes	3	4	1	2
R:R:E190	R:R:R251	11.63	1	Yes	Yes	4	5	2	2
R:R:F193	R:R:R251	5.34	1	Yes	Yes	6	5	2	2
R:R:F193	R:R:F276	3.22	1	Yes	Yes	6	4	2	2
R:R:F276	R:R:R251	10.69	1	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	3.65	1	Yes	No	4	5	2	1
R:R:S281	R:R:Y284	3.82	0	No	Yes	6	7	2	1
R:R:T283	R:R:Y284	6.24	0	No	Yes	8	7	2	1
R:R:F180	R:R:S178	1.32	1	Yes	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	276
Number of Links	317
Number of Hubs	42
Number of Links mediated by Hubs	163
Number of Communities	8
Number of Nodes involved in Communities	58
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	49989
Length Of Smallest Path	3
Average Path Length	12.8054
Length of Longest Path	27
Minimum Path Strength	1.295
Average Path Strength	5.65127
Maximum Path Strength	13.975
Minimum Path Correlation	0.7
Average Path Correlation	0.917977
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	46.5511
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.4805
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • immune system process • inflammatory cell apoptotic process • cellular process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • positive regulation of cell communication • regulation of localization • establishment of protein localization • system process • nitrogen compound transport • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • localization • adiponectin secretion • intracellular protein localization • regulation of biological quality • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • endocrine hormone secretion • positive regulation of protein localization • positive regulation of multicellular organismal process • regulation of hormone secretion • regulation of protein localization • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • positive regulation of protein secretion • endocrine process • positive regulation of transport • protein transport • macromolecule localization • hormone transport • regulation of cell communication • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • cellular anatomical structure • cell junction • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • regulation of peptide secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • peptide secretion • amide transport • negative regulation of protein localization • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1E
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1E
Name	(R)-tacrine(10)-hupyridone
Synonyms	(R)-N-9 -(1 ,2 ,3 ,4 -TETRAHYDROACRIDINYL)-N'-5 -[5 ,6 ,7 ,8 -TETRAHYDRO-2'(1'H)-QUINOLINONYL]-1,10-DIAMINODECANE; (R)-TACRINE(10)-HUPYRIDONE
Identifier
Formula	C32 H44 N4 O
Molecular Weight	500.718
SMILES
PubChem	5287575
Formal Charge	0
Total Atoms	81
Total Chiral Atoms	1
Total Bonds	85
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9IZA_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

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