psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L11	R:R:N17	16.48	No	No	0	8	5
2	R:R:I13	R:R:N17	8.5	No	No	0	3	5
3	R:R:D14	R:R:K166	16.59	No	No	0	5	4
4	R:R:K15	R:R:T185	12.01	No	No	0	3	2
5	R:R:K16	R:R:T185	4.5	No	No	0	4	2
6	R:R:C18	R:R:C183	7.28	No	No	0	9	1
7	R:R:C19	R:R:F21	4.19	No	No	0	4	2
8	R:R:C19	R:R:C266	7.28	No	No	0	4	7
9	R:R:N171	R:R:V20	5.91	No	No	8	1	2
10	R:R:L176	R:R:V20	4.47	Yes	No	8	4	2
11	R:R:F21	R:R:R270	5.34	No	No	0	2	1
12	R:R:D273	R:R:F21	7.17	No	No	0	4	2
13	R:R:R22	R:R:R90	29.85	No	No	0	3	4
14	R:R:R22	R:R:W91	6	No	Yes	0	3	4
15	R:R:A174	R:R:R22	5.53	No	No	0	2	3
16	R:R:D23	R:R:R270	5.96	No	No	0	4	1
17	R:R:D23	R:R:L274	5.43	No	Yes	0	4	1
18	R:R:D24	R:R:R90	5.96	No	No	0	4	4
19	R:R:F25	R:R:L274	6.09	No	Yes	0	6	1
20	R:R:I26	R:R:L30	11.42	No	No	1	5	5
21	R:R:I26	R:R:Y87	3.63	No	Yes	1	5	6
22	R:R:L30	R:R:Y87	12.89	No	Yes	1	5	6
23	R:R:P31	R:R:P32	5.84	No	No	0	6	5
24	R:R:E37	R:R:V33	4.28	Yes	No	1	7	5
25	R:R:S281	R:R:V33	4.85	No	No	1	6	5
26	R:R:L34	R:R:L80	5.54	Yes	No	0	8	8
27	R:R:L34	R:R:L83	4.15	Yes	Yes	1	8	6
28	R:R:L34	R:R:M84	4.24	Yes	No	0	8	7
29	R:R:L34	R:R:Y87	4.69	Yes	Yes	1	8	6
30	R:R:E37	R:R:S281	4.31	Yes	No	1	7	6
31	R:R:E37	R:R:Y284	4.49	Yes	Yes	1	7	7
32	R:R:E37	R:R:M285	5.41	Yes	No	0	7	5
33	R:R:E37	R:R:M288	4.06	Yes	No	0	7	8
34	R:R:F38	R:R:P81	11.56	No	No	0	7	8
35	R:R:F38	R:R:M84	3.73	No	No	0	7	7
36	R:R:F40	R:R:M288	3.73	No	No	0	6	8
37	R:R:G44	R:R:P291	4.06	No	No	0	7	9
38	R:R:D73	R:R:N45	14.81	No	Yes	6	9	9
39	R:R:F74	R:R:N45	6.04	Yes	Yes	6	7	9
40	R:R:I77	R:R:N45	5.66	Yes	Yes	6	6	9
41	R:R:N45	R:R:P291	11.4	Yes	No	6	9	9
42	R:R:F296	R:R:L47	7.31	No	No	0	8	6
43	R:R:F74	R:R:L49	6.09	Yes	No	0	7	7
44	R:R:F54	R:R:W50	6.01	No	No	0	4	4
45	R:R:H55	R:R:W50	13.75	No	No	0	5	4
46	R:R:H55	R:R:I51	6.63	No	No	0	5	7
47	R:R:I51	R:R:L56	4.28	No	No	0	7	5
48	R:R:F301	R:R:I51	10.05	Yes	No	0	9	7
49	R:R:F52	R:R:R63	6.41	Yes	Yes	2	7	7
50	R:R:F52	R:R:F67	5.36	Yes	No	0	7	6
51	R:R:F52	R:R:Y295	7.22	Yes	Yes	2	7	7
52	R:R:F301	R:R:F52	4.29	Yes	Yes	2	9	7
53	R:R:C53	R:R:F54	5.59	No	No	0	4	4
54	R:R:K57	R:R:W59	11.6	No	No	0	5	6
55	R:R:F67	R:R:S58	3.96	No	No	0	6	6
56	R:R:F65	R:R:S61	3.96	Yes	No	0	7	6
57	R:R:I139	R:R:S61	6.19	No	No	0	7	6
58	R:R:D124	R:R:S62	5.89	No	No	9	8	8
59	R:R:R128	R:R:S62	3.95	No	No	9	8	8
60	R:R:L66	R:R:R63	3.64	Yes	Yes	2	8	7
61	R:R:R63	R:R:S298	6.59	Yes	No	0	7	8
62	R:R:F301	R:R:R63	5.34	Yes	Yes	2	9	7
63	R:R:I64	R:R:N141	5.66	No	No	0	7	2
64	R:R:A144	R:R:I64	6.5	No	No	0	7	7
65	R:R:F65	R:R:V120	10.49	Yes	No	0	7	7
66	R:R:F65	R:R:I147	6.28	Yes	No	0	7	5
67	R:R:L66	R:R:V121	5.96	Yes	No	2	8	9
68	R:R:L66	R:R:Y294	4.69	Yes	Yes	2	8	9
69	R:R:L66	R:R:Y295	9.38	Yes	Yes	2	8	7
70	R:R:F67	R:R:N68	3.62	No	Yes	0	6	9
71	R:R:F117	R:R:N68	13.29	Yes	Yes	7	8	9
72	R:R:N68	R:R:S148	10.43	Yes	No	0	9	8
73	R:R:N68	R:R:W152	5.65	Yes	Yes	7	9	9
74	R:R:L118	R:R:L69	5.54	No	Yes	2	9	9
75	R:R:L69	R:R:Y294	5.86	Yes	Yes	2	9	9
76	R:R:L69	R:R:Y295	4.69	Yes	Yes	2	9	7
77	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
78	R:R:V71	R:R:W152	4.9	No	Yes	0	6	9
79	R:R:D73	R:R:S287	5.89	No	No	0	9	8
80	R:R:D73	R:R:P291	4.83	No	No	6	9	9
81	R:R:F74	R:R:I77	3.77	Yes	Yes	6	7	6
82	R:R:F74	R:R:I78	8.79	Yes	No	0	7	6
83	R:R:L75	R:R:N110	10.98	No	Yes	0	6	9
84	R:R:L76	R:R:N110	4.12	No	Yes	0	7	9
85	R:R:L76	R:R:Y284	7.03	No	Yes	0	7	7
86	R:R:L76	R:R:S287	6.01	No	No	0	7	8
87	R:R:I77	R:R:S287	4.64	Yes	No	0	6	8
88	R:R:C79	R:R:L107	4.76	No	Yes	0	6	6
89	R:R:L80	R:R:Y284	8.21	No	Yes	0	8	7
90	R:R:F82	R:R:M103	4.98	No	Yes	0	6	5
91	R:R:L83	R:R:Y87	12.89	Yes	Yes	1	6	6
92	R:R:L83	R:R:M103	4.24	Yes	Yes	1	6	5
93	R:R:L107	R:R:L83	5.54	Yes	Yes	1	6	6
94	L:L:?1	R:R:L83	5.13	Yes	Yes	1	0	6
95	R:R:D85	R:R:F95	4.78	No	No	0	4	7
96	R:R:N86	R:R:W91	6.78	No	Yes	0	5	4
97	R:R:N86	R:R:W93	10.17	No	Yes	0	5	9
98	R:R:W91	R:R:Y87	5.79	Yes	Yes	0	4	6
99	R:R:K94	R:R:R89	8.66	No	No	0	3	4
100	R:R:L176	R:R:W91	6.83	Yes	Yes	0	4	4
101	R:R:F277	R:R:W91	11.02	No	Yes	0	5	4
102	R:R:D92	R:R:K94	6.91	No	No	0	4	3
103	R:R:F95	R:R:W93	16.04	No	Yes	0	7	9
104	R:R:C100	R:R:W93	9.14	No	Yes	0	9	9
105	R:R:M103	R:R:W93	6.98	Yes	Yes	0	5	9
106	R:R:D97	R:R:I98	5.6	No	Yes	3	3	2
107	R:R:D97	R:R:M167	12.48	No	Yes	3	3	3
108	R:R:I98	R:R:R101	3.76	Yes	No	3	2	6
109	R:R:I98	R:R:M167	7.29	Yes	Yes	3	2	3
110	R:R:C100	R:R:P168	5.65	No	Yes	3	9	4
111	R:R:C100	R:R:C177	7.28	No	No	3	9	9
112	R:R:M167	R:R:R101	12.41	Yes	No	3	3	6
113	R:R:L107	R:R:M103	4.24	Yes	Yes	1	6	5
114	R:R:L104	R:R:S179	10.51	No	Yes	1	5	4
115	L:L:?1	R:R:L104	10.27	Yes	No	1	0	5
116	R:R:F105	R:R:M109	12.44	Yes	Yes	5	6	5
117	R:R:F105	R:R:I156	5.02	Yes	No	5	6	4
118	R:R:F105	R:R:T159	6.49	Yes	No	5	6	7
119	R:R:F105	R:R:V160	3.93	Yes	No	5	6	4
120	R:R:F105	R:R:L163	17.05	Yes	No	5	6	5
121	R:R:M106	R:R:N110	4.21	No	Yes	0	5	9
122	R:R:L107	R:R:Y284	7.03	Yes	Yes	1	6	7
123	L:L:?1	R:R:L107	20.53	Yes	Yes	1	0	6
124	R:R:A108	R:R:H189	4.39	No	Yes	0	4	5
125	R:R:M109	R:R:N110	5.61	Yes	Yes	0	5	9
126	R:R:M109	R:R:T155	4.52	Yes	No	0	5	7
127	R:R:I156	R:R:M109	7.29	No	Yes	5	4	5
128	R:R:M109	R:R:T159	9.03	Yes	No	5	5	7
129	R:R:F180	R:R:R111	4.28	Yes	Yes	1	3	8
130	R:R:F193	R:R:R111	8.55	No	Yes	1	6	8
131	R:R:E196	R:R:R111	6.98	Yes	Yes	1	5	8
132	R:R:F244	R:R:R111	5.34	Yes	Yes	1	8	8
133	R:R:R111	R:R:T283	7.76	Yes	Yes	1	8	8
134	L:L:?1	R:R:R111	6.76	Yes	Yes	1	0	8
135	R:R:Q112	R:R:T155	5.67	Yes	No	0	7	7
136	R:R:L158	R:R:Q112	6.65	No	Yes	0	5	7
137	R:R:M192	R:R:Q112	12.23	No	Yes	0	5	7
138	R:R:E196	R:R:Q112	8.92	Yes	Yes	0	5	7
139	R:R:G113	R:R:T155	5.46	No	No	0	7	7
140	R:R:E196	R:R:I115	6.83	Yes	No	1	5	8
141	R:R:F240	R:R:I115	3.77	Yes	No	1	9	8
142	R:R:F244	R:R:I115	10.05	Yes	No	1	8	8
143	R:R:I116	R:R:L151	5.71	No	No	0	5	7
144	R:R:F117	R:R:V120	3.93	Yes	No	7	8	7
145	R:R:F117	R:R:L151	6.09	Yes	No	7	8	7
146	R:R:F117	R:R:W152	13.03	Yes	Yes	7	8	9
147	R:R:D290	R:R:L118	6.79	No	No	2	9	9
148	R:R:L118	R:R:Y294	8.21	No	Yes	2	9	9
149	R:R:P200	R:R:T119	6.99	No	No	0	9	7
150	R:R:I203	R:R:T119	4.56	No	No	0	7	7
151	R:R:I204	R:R:T119	6.08	No	No	0	8	7
152	R:R:L151	R:R:V120	4.47	No	No	7	7	7
153	R:R:R125	R:R:V121	6.54	No	No	2	9	9
154	R:R:V121	R:R:Y294	3.79	No	Yes	2	9	9
155	R:R:D124	R:R:R128	15.48	No	No	9	8	8
156	R:R:R125	R:R:Y294	6.17	No	Yes	2	9	9
157	R:R:F127	R:R:Y126	10.32	Yes	Yes	4	5	7
158	R:R:V130	R:R:Y126	12.62	Yes	Yes	4	8	7
159	R:R:H131	R:R:Y126	6.53	Yes	Yes	4	7	7
160	R:R:F206	R:R:Y126	6.19	No	Yes	0	4	7
161	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
162	R:R:R210	R:R:Y126	6.17	No	Yes	4	4	7
163	R:R:F127	R:R:H131	7.92	Yes	Yes	4	5	7
164	R:R:F127	R:R:H134	4.53	Yes	No	4	5	4
165	R:R:F127	R:R:L136	6.09	Yes	No	4	5	4
166	R:R:N137	R:R:R128	6.03	No	No	0	4	8
167	R:R:I211	R:R:V129	12.29	No	No	0	8	8
168	R:R:L215	R:R:V129	7.45	Yes	No	0	8	8
169	R:R:H131	R:R:V130	8.3	Yes	Yes	4	7	8
170	R:R:R210	R:R:V130	5.23	No	Yes	4	4	8
171	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
172	R:R:H133	R:R:P132	7.63	No	No	0	6	8
173	R:R:H134	R:R:L136	3.86	No	No	4	4	4
174	R:R:H134	R:R:N137	3.83	No	No	0	4	4
175	R:R:S140	R:R:T143	4.8	No	No	0	6	3
176	R:R:L158	R:R:W188	10.25	No	Yes	0	5	5
177	R:R:L163	R:R:V160	4.47	No	No	5	5	4
178	R:R:H161	R:R:L162	12.86	Yes	Yes	1	7	4
179	R:R:H161	R:R:Q187	6.18	Yes	No	0	7	2
180	R:R:H161	R:R:W188	8.46	Yes	Yes	0	7	5
181	R:R:H161	R:R:H189	4.78	Yes	Yes	1	7	5
182	R:R:K165	R:R:L162	5.64	No	Yes	0	4	4
183	R:R:L162	R:R:S179	6.01	Yes	Yes	1	4	4
184	R:R:H189	R:R:L162	14.14	Yes	Yes	1	5	4
185	R:R:K165	R:R:Q187	6.78	No	No	0	4	2
186	R:R:I169	R:R:K166	4.36	No	No	0	1	4
187	R:R:M167	R:R:P168	8.39	Yes	Yes	3	3	4
188	R:R:N175	R:R:P168	11.4	No	Yes	0	4	4
189	R:R:C177	R:R:P168	5.65	No	Yes	3	9	4
190	R:R:L176	R:R:N171	10.98	Yes	No	8	4	1
191	R:R:L176	R:R:S178	6.01	Yes	No	0	4	4
192	L:L:?1	R:R:S178	4.18	Yes	No	0	0	4
193	R:R:H189	R:R:S179	6.97	Yes	Yes	1	5	4
194	L:L:?1	R:R:S179	8.35	Yes	Yes	1	0	4
195	R:R:F180	R:R:H189	20.36	Yes	Yes	1	3	5
196	R:R:F180	R:R:F193	10.72	Yes	No	1	3	6
197	R:R:F180	R:R:F276	8.57	Yes	Yes	1	3	4
198	R:R:F180	R:R:L280	3.65	Yes	Yes	1	3	5
199	L:L:?1	R:R:F180	9.03	Yes	Yes	1	0	3
200	R:R:I182	R:R:Y269	3.63	No	No	0	3	2
201	R:R:D273	R:R:I182	8.4	No	No	0	4	3
202	R:R:H184	R:R:L258	18	No	No	0	3	3
203	R:R:G262	R:R:H184	4.77	No	No	0	4	3
204	R:R:H184	R:R:T263	15.06	No	No	0	3	3
205	R:R:E190	R:R:Q187	8.92	No	No	0	4	2
206	R:R:M192	R:R:W188	9.31	No	Yes	0	5	5
207	R:R:E190	R:R:R251	6.98	No	No	0	4	5
208	R:R:E190	R:R:F255	4.66	No	No	0	4	5
209	R:R:E196	R:R:F193	4.66	Yes	No	1	5	6
210	R:R:F255	R:R:L194	3.65	No	No	0	5	4
211	R:R:F197	R:R:F198	7.5	Yes	No	1	8	5
212	R:R:F197	R:R:L201	13.4	Yes	Yes	1	8	7
213	R:R:F197	R:R:F240	5.36	Yes	Yes	1	8	9
214	R:R:F197	R:R:F244	4.29	Yes	Yes	1	8	8
215	R:R:F197	R:R:L245	4.87	Yes	No	0	8	6
216	R:R:F197	R:R:V248	14.42	Yes	No	1	8	8
217	R:R:F198	R:R:V248	3.93	No	No	1	5	8
218	R:R:I203	R:R:L199	4.28	No	No	0	7	4
219	R:R:L201	R:R:L205	4.15	Yes	No	0	7	4
220	R:R:F240	R:R:L201	3.65	Yes	Yes	1	9	7
221	R:R:F240	R:R:I204	7.54	Yes	No	0	9	8
222	R:R:R210	R:R:W213	7	No	No	0	4	3
223	R:R:Q217	R:R:W213	12.05	No	No	0	5	3
224	R:R:L215	R:R:M220	4.24	Yes	No	0	8	3
225	R:R:I226	R:R:L215	4.28	No	Yes	0	6	8
226	R:R:I230	R:R:L215	4.28	Yes	Yes	0	6	8
227	R:R:D221	R:R:R216	4.76	No	No	0	3	4
228	R:R:M220	R:R:R218	7.44	No	No	0	3	5
229	R:R:H223	R:R:K225	7.86	No	No	0	4	5
230	R:R:H223	R:R:I226	5.3	No	No	0	4	6
231	R:R:I230	R:R:K227	7.27	Yes	No	0	6	4
232	R:R:F232	R:R:R228	12.83	Yes	No	11	7	7
233	R:R:R228	R:R:S297	3.95	No	No	11	7	6
234	R:R:F232	R:R:T231	5.19	Yes	No	0	7	6
235	R:R:F232	R:R:V235	6.55	Yes	No	0	7	5
236	R:R:F232	R:R:S297	14.53	Yes	No	11	7	6
237	R:R:V236	R:R:Y294	12.62	No	Yes	0	8	9
238	R:R:N286	R:R:V239	4.43	Yes	No	0	9	7
239	R:R:F240	R:R:F244	7.5	Yes	Yes	1	9	8
240	R:R:C243	R:R:N286	7.87	No	Yes	0	8	9
241	R:R:F244	R:R:T283	9.08	Yes	Yes	1	8	8
242	R:R:F244	R:R:N286	6.04	Yes	Yes	0	8	9
243	R:R:P246	R:R:T279	6.99	No	No	0	9	7
244	R:R:S247	R:R:T279	6.4	No	No	0	6	7
245	R:R:S247	R:R:T283	4.8	No	Yes	0	6	8
246	R:R:R253	R:R:V250	7.85	No	No	0	5	5
247	R:R:F276	R:R:V250	3.93	Yes	No	0	4	5
248	R:R:I254	R:R:R251	11.27	Yes	No	1	4	5
249	R:R:F276	R:R:R251	8.55	Yes	No	1	4	5
250	R:R:F276	R:R:I254	3.77	Yes	Yes	1	4	4
251	R:R:T260	R:R:W256	3.64	No	No	0	1	4
252	R:R:L257	R:R:Y269	5.86	No	No	0	3	2
253	R:R:L258	R:R:Y269	5.86	No	No	0	3	2
254	R:R:S261	R:R:T260	4.8	No	No	0	3	1
255	R:R:E267	R:R:N265	5.26	No	No	0	2	5
256	R:R:I278	R:R:L274	4.28	No	Yes	0	6	1
257	R:R:F276	R:R:F277	8.57	Yes	No	1	4	5
258	R:R:F276	R:R:L280	6.09	Yes	Yes	1	4	5
259	R:R:F277	R:R:L280	3.65	No	Yes	1	5	5
260	R:R:F282	R:R:T279	3.89	No	No	0	7	7
261	R:R:L280	R:R:T283	4.42	Yes	Yes	1	5	8
262	R:R:F282	R:R:S281	3.96	No	No	0	7	6
263	R:R:F282	R:R:M285	8.71	No	No	0	7	5
264	R:R:T283	R:R:Y284	3.75	Yes	Yes	1	8	7
265	L:L:?1	R:R:Y284	9.78	Yes	Yes	1	0	7
266	R:R:D290	R:R:N286	10.77	No	Yes	0	9	9
267	R:R:D290	R:R:Y294	5.75	No	Yes	2	9	9
268	R:R:F296	R:R:V292	5.24	No	No	0	8	6
269	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	7
270	R:R:F301	R:R:Y295	6.19	Yes	Yes	2	9	7
271	R:R:F296	R:R:F301	5.36	No	Yes	0	8	9
272	R:R:D124	R:R:F65	3.58	No	Yes	0	8	7
273	R:R:P299	R:R:S298	3.56	No	No	0	5	8
274	R:R:G41	R:R:I77	3.53	No	Yes	0	8	6
275	R:R:G35	R:R:M84	3.49	No	No	0	5	7
276	R:R:C18	R:R:S181	3.44	No	No	0	9	4
277	R:R:A144	R:R:S61	3.42	No	No	0	7	6
278	R:R:A237	R:R:S208	3.42	No	No	0	7	8
279	R:R:I98	R:R:P99	3.39	Yes	No	0	2	5
280	R:R:G262	R:R:Q264	3.29	No	No	0	4	3
281	R:R:V129	R:R:V130	3.21	No	Yes	0	8	8
282	R:R:I233	R:R:S208	3.1	No	No	0	7	8
283	R:R:I278	R:R:V29	3.07	No	No	0	6	5
284	R:R:I254	R:R:V272	3.07	Yes	No	0	4	4
285	R:R:K28	R:R:V27	3.04	No	No	0	3	3
286	R:R:I139	R:R:T143	3.04	No	No	0	7	3
287	R:R:I147	R:R:T143	3.04	No	No	0	5	3
288	R:R:L69	R:R:S114	3	Yes	No	0	9	9
289	R:R:L245	R:R:V241	2.98	No	No	0	6	5
290	R:R:L245	R:R:V249	2.98	No	No	0	6	6
291	R:R:I211	R:R:I233	2.94	No	No	0	8	7
292	R:R:I212	R:R:I230	2.94	No	Yes	10	5	6
293	R:R:I212	R:R:I233	2.94	No	No	0	5	7
294	R:R:N17	R:R:T263	2.92	No	No	0	5	3
295	R:R:E12	R:R:V20	2.85	No	No	0	5	2
296	R:R:I26	R:R:L274	2.85	No	Yes	0	5	1
297	R:R:I39	R:R:L42	2.85	No	No	0	5	7
298	R:R:I252	R:R:L194	2.85	No	No	0	6	4
299	R:R:I254	R:R:L258	2.85	Yes	No	0	4	3
300	R:R:L289	R:R:M288	2.83	No	No	0	7	8
301	R:R:P31	R:R:Y87	2.78	No	Yes	0	6	6
302	R:R:A48	R:R:Y295	2.67	No	Yes	0	9	7
303	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
304	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
305	R:R:F40	R:R:I39	2.51	No	No	0	6	5
306	R:R:I212	R:R:R216	2.51	No	No	10	5	4
307	R:R:I230	R:R:R216	2.51	Yes	No	10	6	4
308	R:R:K60	R:R:R63	2.48	No	Yes	0	7	7
309	R:R:Q219	R:R:R222	2.34	No	No	0	3	3
310	R:R:L56	R:R:W59	2.28	No	No	0	5	6
311	R:R:F186	R:R:F255	2.14	No	No	0	4	5
312	R:R:G172	R:R:G173	2.11	No	No	0	3	4
313	R:R:G157	R:R:V160	1.84	No	No	0	5	4
314	R:R:C149	R:R:S148	1.72	No	No	0	4	8
315	R:R:G44	R:R:L43	1.71	No	No	0	7	4
316	R:R:A145	R:R:S148	1.71	No	No	0	3	8
317	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
318	R:R:G172	R:R:N171	1.7	No	No	0	3	1
319	R:R:C183	R:R:T185	1.69	No	No	0	1	2
320	R:R:G172	R:R:Q170	1.64	No	No	0	3	1
321	R:R:C243	R:R:I242	1.64	No	No	0	8	5
322	R:R:S178	R:R:S181	1.63	No	No	0	4	4
323	R:R:A122	R:R:I204	1.62	No	No	0	9	8
324	R:R:S271	R:R:V272	1.62	No	No	0	3	4
325	R:R:A237	R:R:M234	1.61	No	No	0	7	4
326	R:R:V235	R:R:V239	1.6	No	No	0	5	7
327	R:R:V235	R:R:V293	1.6	No	No	0	5	8
328	R:R:V236	R:R:V293	1.6	No	No	0	8	8
329	R:R:V292	R:R:V293	1.6	No	No	0	6	8
330	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
331	R:R:L257	R:R:S261	1.5	No	No	0	3	3
332	R:R:L257	R:R:V268	1.49	No	No	0	3	1
333	R:R:D85	R:R:V88	1.46	No	No	0	4	3
334	R:R:I98	R:R:L102	1.43	Yes	No	0	2	5
335	R:R:I154	R:R:L150	1.43	No	No	0	5	4
336	R:R:I169	R:R:L176	1.43	No	Yes	0	1	4
337	R:R:G153	R:R:W152	1.41	No	Yes	0	4	9
338	R:R:K138	R:R:N137	1.4	No	No	0	4	4
339	R:R:L195	R:R:L199	1.38	No	No	0	4	4
340	R:R:D92	R:R:N175	1.35	No	No	0	4	4
341	R:R:R63	R:R:S300	1.32	Yes	No	0	7	5
342	R:R:R142	R:R:S140	1.32	No	No	0	4	6
343	R:R:A191	R:R:W188	1.3	No	Yes	0	3	5
344	R:R:F40	R:R:L36	1.22	No	No	0	6	4
345	R:R:D221	R:R:R222	1.19	No	No	0	3	3
346	R:R:E267	R:R:R270	1.16	No	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L34	4.655	4	1	8
2	R:R:E37	4.51	5	1	7
3	R:R:N45	9.4775	4	6	9
4	R:R:F52	5.82	4	2	7
5	R:R:R63	4.29667	6	2	7
6	R:R:F65	6.0775	4	0	7
7	R:R:L66	5.9175	4	2	8
8	R:R:N68	8.2475	4	7	9
9	R:R:L69	4.7725	4	2	9
10	R:R:F74	6.1725	4	6	7
11	R:R:I77	4.4	4	6	6
12	R:R:L83	6.39	5	1	6
13	R:R:Y87	7.11167	6	1	6
14	R:R:W91	7.284	5	0	4
15	R:R:W93	10.5825	4	0	9
16	R:R:I98	4.294	5	3	2
17	R:R:M103	5.11	4	1	5
18	R:R:F105	8.986	5	5	6
19	R:R:L107	8.42	5	1	6
20	R:R:M109	7.778	5	5	5
21	R:R:N110	6.23	4	0	9
22	R:R:R111	6.61167	6	1	8
23	R:R:Q112	8.3675	4	0	7
24	R:R:F117	9.085	4	7	8
25	R:R:Y126	8.54	6	4	7
26	R:R:F127	6.296	5	4	5
27	R:R:V130	7.164	5	4	8
28	R:R:H131	6.07	4	4	7
29	R:R:W152	5.516	5	7	9
30	R:R:H161	8.07	4	1	7
31	R:R:L162	9.6625	4	1	4
32	R:R:M167	10.1425	4	3	3
33	R:R:P168	7.7725	4	3	4
34	R:R:L176	5.944	5	8	4
35	R:R:S179	7.96	4	1	4
36	R:R:F180	9.435	6	1	3
37	R:R:W188	7.33	4	0	5
38	R:R:H189	10.128	5	1	5
39	R:R:E196	6.8475	4	1	5
40	R:R:F197	8.30667	6	1	8
41	R:R:L201	5.7275	4	1	7
42	R:R:L215	5.0625	4	0	8
43	R:R:I230	4.25	4	10	6
44	R:R:F232	9.775	4	11	7
45	R:R:F240	5.564	5	1	9
46	R:R:F244	7.05	6	1	8
47	R:R:I254	5.24	4	1	4
48	R:R:L274	4.6625	4	0	1
49	R:R:F276	6.58	6	1	4
50	R:R:L280	4.4525	4	1	5
51	R:R:T283	5.962	5	1	8
52	R:R:Y284	6.715	6	1	7
53	R:R:N286	7.2775	4	0	9
54	R:R:Y294	6.3825	8	2	9
55	R:R:Y295	5.44571	7	2	7
56	R:R:F301	6.246	5	2	9
57	L:L:?1	9.25375	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F276	R:R:I254	27.6777	3.77	Yes	Yes	1	4	4
2	R:R:I254	R:R:L258	24.718	2.85	Yes	No	0	4	3
3	R:R:H184	R:R:L258	10.0611	18	No	No	0	3	3
4	L:L:?1	R:R:S178	12.9447	4.18	Yes	No	0	0	4
5	R:R:F180	R:R:F276	19.9375	8.57	Yes	Yes	1	3	4
6	R:R:L258	R:R:Y269	14.0617	5.86	No	No	0	3	2
7	R:R:I26	R:R:Y87	12.9936	3.63	No	Yes	1	5	6
8	R:R:I26	R:R:L274	11.9391	2.85	No	Yes	0	5	1
9	R:R:E37	R:R:Y284	11.4825	4.49	Yes	Yes	1	7	7
10	R:R:T283	R:R:Y284	29.6562	3.75	Yes	Yes	1	8	7
11	R:R:L280	R:R:T283	20.1549	4.42	Yes	Yes	1	5	8
12	R:R:F276	R:R:L280	15.6978	6.09	Yes	Yes	1	4	5
13	L:L:?1	R:R:L83	24.3076	5.13	Yes	Yes	1	0	6
14	R:R:L76	R:R:S287	12.8469	6.01	No	No	0	7	8
15	R:R:L76	R:R:Y284	22.7694	7.03	No	Yes	0	7	7
16	R:R:F244	R:R:N286	100	6.04	Yes	Yes	0	8	9
17	R:R:F244	R:R:R111	57.2931	5.34	Yes	Yes	1	8	8
18	R:R:F180	R:R:R111	17.4725	4.28	Yes	Yes	1	3	8
19	R:R:Y294	R:R:Y295	81.984	3.97	Yes	Yes	2	9	7
20	R:R:D290	R:R:Y294	88.4604	5.75	No	Yes	2	9	9
21	R:R:D290	R:R:N286	91.3385	10.77	No	Yes	0	9	9
22	R:R:F244	R:R:T283	42.7313	9.08	Yes	Yes	1	8	8
23	R:R:F52	R:R:Y295	72.768	7.22	Yes	Yes	2	7	7
24	R:R:F52	R:R:F67	77.8394	5.36	Yes	No	0	7	6
25	R:R:F65	R:R:V120	67.7076	10.49	Yes	No	0	7	7
26	R:R:F117	R:R:V120	68.1152	3.93	Yes	No	7	8	7
27	R:R:F117	R:R:N68	69.9198	13.29	Yes	Yes	7	8	9
28	R:R:F67	R:R:N68	76.4642	3.62	No	Yes	0	6	9
29	R:R:D124	R:R:F65	59.9484	3.58	No	Yes	0	8	7
30	R:R:D124	R:R:R128	58.1601	15.48	No	No	9	8	8
31	R:R:L76	R:R:N110	10.2133	4.12	No	Yes	0	7	9
32	L:L:?1	R:R:L107	11.314	20.53	Yes	Yes	1	0	6
33	R:R:L83	R:R:M103	11.3711	4.24	Yes	Yes	1	6	5
34	R:R:L107	R:R:M103	20.2636	4.24	Yes	Yes	1	6	5
35	R:R:C100	R:R:P168	20.4158	5.65	No	Yes	3	9	4
36	R:R:C100	R:R:W93	24.0929	9.14	No	Yes	0	9	9
37	R:R:M167	R:R:P168	11.2325	8.39	Yes	Yes	3	3	4
38	R:R:Q112	R:R:T155	10.39	5.67	Yes	No	0	7	7
39	R:R:E196	R:R:Q112	16.6191	8.92	Yes	Yes	0	5	7
40	R:R:E196	R:R:R111	10.0258	6.98	Yes	Yes	1	5	8
41	R:R:F240	R:R:F244	10.4661	7.5	Yes	Yes	1	9	8
42	R:R:F127	R:R:H134	54.0427	4.53	Yes	No	4	5	4
43	R:R:H134	R:R:N137	55.8826	3.83	No	No	0	4	4
44	R:R:N137	R:R:R128	57.5513	6.03	No	No	0	4	8
45	R:R:F127	R:R:Y126	27.7048	10.32	Yes	Yes	4	5	7
46	R:R:V130	R:R:Y126	21.9242	12.62	Yes	Yes	4	8	7
47	R:R:F127	R:R:H131	24.7615	7.92	Yes	Yes	4	5	7
48	R:R:H131	R:R:V130	21.9486	8.3	Yes	Yes	4	7	8
49	R:R:I211	R:R:V129	12.1647	12.29	No	No	0	8	8
50	R:R:V129	R:R:V130	40.2364	3.21	No	Yes	0	8	8
51	R:R:L215	R:R:V129	26.2345	7.45	Yes	No	0	8	8
52	R:R:I230	R:R:L215	14.3253	4.28	Yes	Yes	0	6	8
53	R:R:I211	R:R:I233	10.1291	2.94	No	No	0	8	7
54	R:R:L83	R:R:Y87	13.9965	12.89	Yes	Yes	1	6	6
55	L:L:?1	R:R:R111	37.2741	6.76	Yes	Yes	1	0	8
56	R:R:M103	R:R:W93	28.0228	6.98	Yes	Yes	0	5	9
57	R:R:L107	R:R:Y284	13.4502	7.03	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L34	R:R:L80	5.54	1	Yes	No	8	8	2	2
R:R:L34	R:R:L83	4.15	1	Yes	Yes	8	6	2	1
R:R:L34	R:R:Y87	4.69	1	Yes	Yes	8	6	2	2
R:R:E37	R:R:Y284	4.49	1	Yes	Yes	7	7	2	1
R:R:L76	R:R:Y284	7.03	0	No	Yes	7	7	2	1
R:R:C79	R:R:L107	4.76	0	No	Yes	6	6	2	1
R:R:L80	R:R:Y284	8.21	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	12.89	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L107	R:R:L83	5.54	1	Yes	Yes	6	6	1	1
L:L:?1	R:R:L83	5.13	1	Yes	Yes	0	6	0	1
R:R:L107	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L104	R:R:S179	10.51	1	No	Yes	5	4	1	1
L:L:?1	R:R:L104	10.27	1	Yes	No	0	5	0	1
R:R:L107	R:R:Y284	7.03	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:L107	20.53	1	Yes	Yes	0	6	0	1
R:R:F180	R:R:R111	4.28	1	Yes	Yes	3	8	1	1
R:R:F193	R:R:R111	8.55	1	No	Yes	6	8	2	1
R:R:E196	R:R:R111	6.98	1	Yes	Yes	5	8	2	1
R:R:F244	R:R:R111	5.34	1	Yes	Yes	8	8	2	1
R:R:R111	R:R:T283	7.76	1	Yes	Yes	8	8	1	2
L:L:?1	R:R:R111	6.76	1	Yes	Yes	0	8	0	1
R:R:L162	R:R:S179	6.01	1	Yes	Yes	4	4	2	1
R:R:H189	R:R:L162	14.14	1	Yes	Yes	5	4	2	2
R:R:L176	R:R:S178	6.01	8	Yes	No	4	4	2	1
L:L:?1	R:R:S178	4.18	1	Yes	No	0	4	0	1
R:R:H189	R:R:S179	6.97	1	Yes	Yes	5	4	2	1
L:L:?1	R:R:S179	8.35	1	Yes	Yes	0	4	0	1
R:R:F180	R:R:H189	20.36	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F193	10.72	1	Yes	No	3	6	1	2
R:R:F180	R:R:F276	8.57	1	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	1	Yes	Yes	3	5	1	2
L:L:?1	R:R:F180	9.03	1	Yes	Yes	0	3	0	1
R:R:E196	R:R:F193	4.66	1	Yes	No	5	6	2	2
R:R:F244	R:R:T283	9.08	1	Yes	Yes	8	8	2	2
R:R:F276	R:R:L280	6.09	1	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	4.42	1	Yes	Yes	5	8	2	2
R:R:T283	R:R:Y284	3.75	1	Yes	Yes	8	7	2	1
L:L:?1	R:R:Y284	9.78	1	Yes	Yes	0	7	0	1
R:R:S178	R:R:S181	1.63	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IQT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.62
Number of Linked Nodes	281
Number of Links	346
Number of Hubs	57
Number of Links mediated by Hubs	203
Number of Communities	11
Number of Nodes involved in Communities	87
Number of Links involved in Communities	127

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	69736
Length Of Smallest Path	3
Average Path Length	15.1423
Length of Longest Path	36
Minimum Path Strength	1.495
Average Path Strength	6.59199
Maximum Path Strength	17.925
Minimum Path Correlation	0.7
Average Path Correlation	0.918128
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	44.6791
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	56.565
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	β-pyridinecarboxylic acid
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9IQT_nogp_Chain_R F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	PubChem 25101223		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	9JKY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.72	2025-10-29	To be published
	9JKY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.72	2025-10-29	To be published
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	PubChem 25101223		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	PubChem 25101223		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Monomethyl fumarate	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9KT7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.8	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	2.73	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT8 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		2.73	2025-12-10	10.1021/acs.jmedchem.4c02567

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