psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F21	R:R:H9	6.79	Yes	No	0	2	6
2	R:R:E12	R:R:F10	8.16	No	No	0	5	7
3	R:R:F10	R:R:N17	4.83	No	No	0	7	5
4	R:R:L11	R:R:N171	8.24	No	No	0	8	1
5	R:R:E12	R:R:K16	4.05	No	No	0	5	4
6	R:R:C18	R:R:I13	6.55	No	No	0	9	3
7	R:R:I13	R:R:I169	7.36	No	No	0	3	1
8	R:R:K15	R:R:T185	6.01	No	No	0	3	2
9	R:R:K16	R:R:N17	6.99	No	No	0	4	5
10	R:R:N17	R:R:Q264	14.52	No	No	0	5	3
11	R:R:C18	R:R:C183	7.28	No	No	0	9	1
12	R:R:C19	R:R:C266	7.28	No	No	0	4	7
13	R:R:N171	R:R:V20	4.43	No	No	0	1	2
14	R:R:D23	R:R:F21	4.78	No	Yes	0	4	2
15	R:R:D273	R:R:F21	7.17	No	Yes	0	4	2
16	R:R:R22	R:R:R90	21.32	No	No	0	3	4
17	R:R:R22	R:R:W91	12	No	Yes	0	3	4
18	R:R:D92	R:R:R22	5.96	No	No	0	4	3
19	R:R:D23	R:R:D24	6.65	No	No	0	4	4
20	R:R:D24	R:R:F25	22.69	No	No	0	4	6
21	R:R:F25	R:R:L274	4.87	No	No	0	6	1
22	R:R:I26	R:R:L274	4.28	No	No	0	5	1
23	R:R:P31	R:R:V27	7.07	No	No	0	6	3
24	R:R:L30	R:R:Y87	7.03	No	Yes	0	5	6
25	R:R:P31	R:R:P32	7.79	No	No	0	6	5
26	R:R:M84	R:R:P31	6.71	No	No	0	7	6
27	R:R:S281	R:R:V33	4.85	No	No	0	6	5
28	R:R:L34	R:R:L80	4.15	No	No	0	8	8
29	R:R:F40	R:R:L36	12.18	No	No	0	6	4
30	R:R:E37	R:R:M285	9.47	No	No	0	7	5
31	R:R:E37	R:R:M288	5.41	No	No	0	7	8
32	R:R:F38	R:R:L42	9.74	Yes	No	0	7	7
33	R:R:F38	R:R:P81	14.45	Yes	No	0	7	8
34	R:R:G44	R:R:P291	4.06	No	No	0	7	9
35	R:R:D73	R:R:N45	4.04	Yes	No	0	9	9
36	R:R:F74	R:R:N45	6.04	No	No	0	7	9
37	R:R:I77	R:R:N45	4.25	No	No	0	6	9
38	R:R:I51	R:R:L47	4.28	No	No	0	7	6
39	R:R:F296	R:R:L47	7.31	No	No	0	8	6
40	R:R:F74	R:R:L49	4.87	No	No	0	7	7
41	R:R:F54	R:R:W50	13.03	No	No	0	4	4
42	R:R:H55	R:R:I51	5.3	No	No	0	5	7
43	R:R:F301	R:R:I51	10.05	Yes	No	0	9	7
44	R:R:F52	R:R:F67	7.5	No	Yes	0	7	6
45	R:R:F52	R:R:Y295	5.16	No	Yes	0	7	7
46	R:R:F301	R:R:F52	4.29	Yes	No	0	9	7
47	R:R:C53	R:R:F54	8.38	No	No	0	4	4
48	R:R:L56	R:R:S58	4.5	No	No	0	5	6
49	R:R:L56	R:R:W59	7.97	No	No	0	5	6
50	R:R:L56	R:R:R63	7.29	No	No	0	5	7
51	R:R:I64	R:R:W59	5.87	No	No	0	7	6
52	R:R:F67	R:R:W59	8.02	Yes	No	0	6	6
53	R:R:I139	R:R:S61	7.74	No	No	0	7	6
54	R:R:D124	R:R:S62	7.36	No	No	5	8	8
55	R:R:R128	R:R:S62	6.59	No	No	5	8	8
56	R:R:I64	R:R:N141	4.25	No	No	0	7	2
57	R:R:A144	R:R:I64	4.87	No	No	0	7	7
58	R:R:F65	R:R:V120	9.18	No	No	0	7	7
59	R:R:F65	R:R:I147	5.02	No	No	0	7	5
60	R:R:L66	R:R:Y294	4.69	No	Yes	0	8	9
61	R:R:L66	R:R:Y295	7.03	No	Yes	0	8	7
62	R:R:F67	R:R:V71	7.87	Yes	No	0	6	6
63	R:R:F117	R:R:N68	14.5	No	No	6	8	9
64	R:R:N68	R:R:S148	8.94	No	No	0	9	8
65	R:R:N68	R:R:W152	5.65	No	No	6	9	9
66	R:R:D73	R:R:L69	5.43	Yes	No	2	9	9
67	R:R:D290	R:R:L69	6.79	Yes	No	2	9	9
68	R:R:D73	R:R:S114	4.42	Yes	No	0	9	9
69	R:R:D73	R:R:S287	10.31	Yes	No	0	9	8
70	R:R:D290	R:R:D73	11.98	Yes	Yes	2	9	9
71	R:R:F74	R:R:I78	8.79	No	No	0	7	6
72	R:R:L75	R:R:N110	12.36	No	Yes	0	6	9
73	R:R:L107	R:R:L76	4.15	No	No	0	6	7
74	R:R:L76	R:R:N110	4.12	No	Yes	0	7	9
75	R:R:L76	R:R:S287	6.01	No	No	0	7	8
76	R:R:L80	R:R:Y284	5.86	No	Yes	0	8	7
77	R:R:F82	R:R:F95	10.72	No	Yes	0	6	7
78	R:R:L83	R:R:Y87	14.07	No	Yes	1	6	6
79	R:R:L83	R:R:M103	5.65	No	No	0	6	5
80	L:L:?1	R:R:L83	7.13	Yes	No	1	0	6
81	R:R:D85	R:R:R89	8.34	No	No	3	4	4
82	R:R:D85	R:R:K94	8.3	No	No	3	4	3
83	R:R:D85	R:R:F95	8.36	No	Yes	3	4	7
84	R:R:N86	R:R:W91	5.65	No	Yes	0	5	4
85	R:R:N86	R:R:W93	9.04	No	Yes	0	5	9
86	R:R:W91	R:R:Y87	12.54	Yes	Yes	1	4	6
87	R:R:F277	R:R:Y87	4.13	No	Yes	1	5	6
88	L:L:?1	R:R:Y87	8.05	Yes	Yes	1	0	6
89	R:R:K94	R:R:R89	8.66	No	No	3	3	4
90	R:R:L176	R:R:W91	5.69	No	Yes	0	4	4
91	R:R:S178	R:R:W91	6.18	No	Yes	0	4	4
92	R:R:F277	R:R:W91	12.03	No	Yes	1	5	4
93	L:L:?1	R:R:W91	5.87	Yes	Yes	1	0	4
94	R:R:F95	R:R:W93	12.03	Yes	Yes	3	7	9
95	R:R:C100	R:R:W93	10.45	No	Yes	3	9	9
96	R:R:M103	R:R:W93	4.65	No	Yes	0	5	9
97	R:R:N175	R:R:W93	5.65	No	Yes	0	4	9
98	R:R:C177	R:R:W93	15.67	No	Yes	3	9	9
99	R:R:F95	R:R:K94	7.44	Yes	No	3	7	3
100	R:R:F95	R:R:P99	5.78	Yes	No	0	7	5
101	R:R:D97	R:R:I98	4.2	No	No	0	3	2
102	R:R:D97	R:R:R101	10.72	No	No	0	3	6
103	R:R:D97	R:R:P168	9.66	No	No	0	3	4
104	R:R:C100	R:R:M167	4.86	No	Yes	0	9	3
105	R:R:C100	R:R:C177	7.28	No	No	3	9	9
106	R:R:L107	R:R:M103	4.24	No	No	0	6	5
107	R:R:L104	R:R:M167	4.24	No	Yes	0	5	3
108	R:R:C177	R:R:L104	4.76	No	No	0	9	5
109	L:L:?1	R:R:L104	5.94	Yes	No	0	0	5
110	R:R:F105	R:R:M109	6.22	Yes	Yes	7	6	5
111	R:R:F105	R:R:T159	6.49	Yes	No	7	6	7
112	R:R:F105	R:R:L163	8.53	Yes	No	0	6	5
113	R:R:M106	R:R:N110	5.61	No	Yes	0	5	9
114	L:L:?1	R:R:L107	10.7	Yes	No	0	0	6
115	R:R:M109	R:R:N110	8.41	Yes	Yes	0	5	9
116	R:R:M109	R:R:T155	9.03	Yes	No	0	5	7
117	R:R:M109	R:R:T159	7.53	Yes	No	7	5	7
118	R:R:E196	R:R:R111	6.98	No	Yes	0	5	8
119	R:R:R111	R:R:T283	7.76	Yes	Yes	1	8	8
120	R:R:R111	R:R:Y284	4.12	Yes	Yes	1	8	7
121	L:L:?1	R:R:R111	11.47	Yes	Yes	1	0	8
122	R:R:I116	R:R:Q112	4.12	No	Yes	0	5	7
123	R:R:Q112	R:R:T155	4.25	Yes	No	0	7	7
124	R:R:M192	R:R:Q112	8.16	No	Yes	0	5	7
125	R:R:E196	R:R:Q112	10.19	No	Yes	0	5	7
126	R:R:G113	R:R:T155	5.46	No	No	0	7	7
127	R:R:E196	R:R:I115	6.83	No	No	0	5	8
128	R:R:F244	R:R:I115	10.05	Yes	No	0	8	8
129	R:R:I116	R:R:L151	5.71	No	Yes	0	5	7
130	R:R:F117	R:R:L151	6.09	No	Yes	0	8	7
131	R:R:F117	R:R:W152	10.02	No	No	6	8	9
132	R:R:D290	R:R:L118	4.07	Yes	No	2	9	9
133	R:R:L118	R:R:Y294	7.03	No	Yes	2	9	9
134	R:R:P200	R:R:T119	5.25	No	No	0	9	7
135	R:R:I203	R:R:T119	4.56	No	No	0	7	7
136	R:R:L151	R:R:V120	4.47	Yes	No	0	7	7
137	R:R:R125	R:R:V121	6.54	No	No	2	9	9
138	R:R:V121	R:R:Y294	5.05	No	Yes	2	9	9
139	R:R:D124	R:R:R128	13.1	No	No	5	8	8
140	R:R:R125	R:R:Y294	8.23	No	Yes	2	9	9
141	R:R:F127	R:R:Y126	5.16	Yes	Yes	4	5	7
142	R:R:V130	R:R:Y126	12.62	Yes	Yes	4	8	7
143	R:R:H131	R:R:Y126	7.62	Yes	Yes	4	7	7
144	R:R:F206	R:R:Y126	7.22	No	Yes	4	4	7
145	R:R:C207	R:R:Y126	9.41	No	Yes	0	8	7
146	R:R:R210	R:R:Y126	13.38	Yes	Yes	4	4	7
147	R:R:F127	R:R:H131	6.79	Yes	Yes	4	5	7
148	R:R:F127	R:R:H134	12.44	Yes	No	0	5	4
149	R:R:F127	R:R:L136	9.74	Yes	No	0	5	4
150	R:R:N137	R:R:R128	7.23	No	No	0	4	8
151	R:R:I211	R:R:V129	10.75	No	No	0	8	8
152	R:R:H131	R:R:V130	4.15	Yes	Yes	4	7	8
153	R:R:R210	R:R:V130	6.54	Yes	Yes	4	4	8
154	R:R:S214	R:R:V130	6.46	No	Yes	0	5	8
155	R:R:H133	R:R:P132	6.1	No	No	0	6	8
156	R:R:I139	R:R:T143	4.56	No	No	0	7	3
157	R:R:S140	R:R:T143	4.8	No	No	0	6	3
158	R:R:L158	R:R:W188	7.97	No	No	0	5	5
159	R:R:H161	R:R:L162	10.29	No	No	1	7	4
160	R:R:H161	R:R:H189	7.17	No	Yes	1	7	5
161	R:R:H189	R:R:L162	10.29	Yes	No	1	5	4
162	R:R:K165	R:R:M167	4.32	No	Yes	0	4	3
163	R:R:N175	R:R:P168	6.52	No	No	0	4	4
164	R:R:L176	R:R:N171	5.49	No	No	0	4	1
165	R:R:F180	R:R:S179	5.28	Yes	No	1	3	4
166	R:R:H189	R:R:S179	9.76	Yes	No	1	5	4
167	L:L:?1	R:R:S179	11.6	Yes	No	1	0	4
168	R:R:F180	R:R:H189	22.63	Yes	Yes	1	3	5
169	R:R:E190	R:R:F180	7	Yes	Yes	0	4	3
170	R:R:F180	R:R:F193	11.79	Yes	Yes	0	3	6
171	R:R:F180	R:R:F276	5.36	Yes	No	0	3	4
172	L:L:?1	R:R:F180	5.23	Yes	Yes	1	0	3
173	R:R:I182	R:R:I254	4.42	No	No	0	3	4
174	R:R:D273	R:R:I182	9.8	No	No	0	4	3
175	R:R:H184	R:R:T185	8.21	No	No	0	3	2
176	R:R:H184	R:R:H259	9.55	No	No	0	3	1
177	R:R:Q187	R:R:T185	7.09	No	No	0	2	2
178	R:R:F186	R:R:F255	22.51	No	No	0	4	5
179	R:R:E190	R:R:Q187	7.65	Yes	No	0	4	2
180	R:R:E190	R:R:R251	16.28	Yes	Yes	0	4	5
181	R:R:E190	R:R:F255	9.33	Yes	No	0	4	5
182	R:R:F193	R:R:V248	6.55	Yes	No	0	6	8
183	R:R:F193	R:R:R251	6.41	Yes	Yes	0	6	5
184	R:R:I252	R:R:L194	4.28	No	No	0	6	4
185	R:R:F197	R:R:F198	6.43	Yes	No	0	8	5
186	R:R:F197	R:R:L245	6.09	Yes	No	0	8	6
187	R:R:F197	R:R:V248	15.73	Yes	No	0	8	8
188	R:R:L199	R:R:P200	4.93	No	No	0	4	9
189	R:R:I203	R:R:L199	4.28	No	No	0	7	4
190	R:R:L201	R:R:L205	5.54	Yes	No	0	7	4
191	R:R:F206	R:R:R210	8.55	No	Yes	4	4	4
192	R:R:I211	R:R:I233	4.42	No	No	0	8	7
193	R:R:I212	R:R:R216	5.01	No	No	0	5	4
194	R:R:L215	R:R:M220	4.24	No	No	0	8	3
195	R:R:I230	R:R:L215	5.71	No	No	0	6	8
196	R:R:D221	R:R:R216	14.29	No	No	8	3	4
197	R:R:K227	R:R:R216	4.95	No	No	8	4	4
198	R:R:M220	R:R:R218	7.44	No	No	0	3	5
199	R:R:I226	R:R:M220	4.37	No	No	0	6	3
200	R:R:D221	R:R:K227	5.53	No	No	8	3	4
201	R:R:H223	R:R:K225	10.48	No	No	0	4	5
202	R:R:H223	R:R:I226	6.63	No	No	0	4	6
203	R:R:F232	R:R:R228	8.55	No	No	0	7	7
204	R:R:P299	R:R:R228	12.97	No	No	0	5	7
205	R:R:F232	R:R:S297	11.89	No	No	0	7	6
206	R:R:V236	R:R:Y294	10.09	No	Yes	0	8	9
207	R:R:F240	R:R:F244	7.5	No	Yes	0	9	8
208	R:R:C243	R:R:N286	6.3	No	No	0	8	9
209	R:R:F244	R:R:T283	5.19	Yes	Yes	0	8	8
210	R:R:F244	R:R:N286	10.87	Yes	No	0	8	9
211	R:R:F282	R:R:P246	4.33	No	No	0	7	9
212	R:R:F276	R:R:V250	6.55	No	No	0	4	5
213	R:R:T279	R:R:V250	4.76	No	No	0	7	5
214	R:R:I254	R:R:R251	6.26	No	Yes	0	4	5
215	R:R:F276	R:R:R251	13.9	No	Yes	0	4	5
216	R:R:L257	R:R:R253	4.86	No	No	0	3	5
217	R:R:I254	R:R:V272	4.61	No	No	0	4	4
218	R:R:T260	R:R:W256	15.77	No	No	0	1	4
219	R:R:H259	R:R:L258	5.14	No	No	0	1	3
220	R:R:G262	R:R:Y269	4.35	No	Yes	0	4	2
221	R:R:E267	R:R:N265	21.03	No	No	0	2	5
222	R:R:C266	R:R:Y269	4.03	No	Yes	0	7	2
223	R:R:E267	R:R:V268	7.13	No	No	0	2	1
224	R:R:L280	R:R:T283	7.37	No	Yes	0	5	8
225	R:R:T283	R:R:Y284	4.99	Yes	Yes	1	8	7
226	L:L:?1	R:R:Y284	9.06	Yes	Yes	1	0	7
227	R:R:D290	R:R:N286	8.08	Yes	No	0	9	9
228	R:R:D290	R:R:Y294	6.9	Yes	Yes	2	9	9
229	R:R:F296	R:R:P291	4.33	No	No	0	8	9
230	R:R:V293	R:R:Y294	5.05	No	Yes	0	8	9
231	R:R:F296	R:R:F301	5.36	No	Yes	0	8	9
232	R:R:P299	R:R:S298	5.34	No	No	0	5	8
233	R:R:S298	R:R:S300	4.89	No	No	0	8	5
234	R:R:A48	R:R:Y295	4	No	Yes	0	9	7
235	R:R:A70	R:R:Y295	4	No	Yes	0	8	7
236	R:R:L158	R:R:Q112	3.99	No	Yes	0	5	7
237	R:R:F193	R:R:S247	3.96	Yes	No	0	6	6
238	R:R:F282	R:R:S281	3.96	No	No	0	7	6
239	R:R:F105	R:R:V160	3.93	Yes	No	0	6	4
240	R:R:F240	R:R:I204	3.77	No	No	0	9	8
241	R:R:F40	R:R:M288	3.73	No	No	0	6	8
242	R:R:F197	R:R:L201	3.65	Yes	Yes	0	8	7
243	R:R:F240	R:R:L201	3.65	No	Yes	0	9	7
244	R:R:L257	R:R:Y269	3.52	No	Yes	0	3	2
245	R:R:L258	R:R:Y269	3.52	No	Yes	0	3	2
246	R:R:Q217	R:R:R218	3.5	No	No	0	5	5
247	R:R:P246	R:R:T279	3.5	No	No	0	9	7
248	R:R:A144	R:R:S61	3.42	No	No	0	7	6
249	R:R:I115	R:R:P200	3.39	No	No	0	8	9
250	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
251	R:R:C79	R:R:M106	3.24	No	No	0	6	5
252	R:R:S181	R:R:V20	3.23	No	No	0	4	2
253	R:R:V129	R:R:V130	3.21	No	Yes	0	8	8
254	R:R:S261	R:R:T260	3.2	No	No	0	3	1
255	R:R:I233	R:R:S208	3.1	No	No	0	7	8
256	R:R:A174	R:R:D92	3.09	No	No	0	2	4
257	R:R:I278	R:R:V29	3.07	No	No	0	6	5
258	R:R:R253	R:R:W256	3	No	No	0	5	4
259	R:R:L215	R:R:V129	2.98	No	No	0	8	8
260	R:R:L194	R:R:V248	2.98	No	No	0	4	8
261	R:R:I212	R:R:I230	2.94	No	No	0	5	6
262	R:R:I156	R:R:M109	2.92	No	Yes	0	4	5
263	R:R:I169	R:R:M167	2.92	No	Yes	0	1	3
264	R:R:I154	R:R:L150	2.85	No	No	0	5	4
265	R:R:L34	R:R:M84	2.83	No	No	0	8	7
266	R:R:Q264	R:R:T263	2.83	No	No	0	3	3
267	R:R:L289	R:R:M288	2.83	No	No	0	7	8
268	R:R:G96	R:R:W93	2.81	No	Yes	0	7	9
269	R:R:D14	R:R:I13	2.8	No	No	0	5	3
270	R:R:A191	R:R:F186	2.77	No	No	0	3	4
271	R:R:F301	R:R:S300	2.64	Yes	No	0	9	5
272	R:R:R89	R:R:V88	2.62	No	No	0	4	3
273	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
274	R:R:A72	R:R:W152	2.59	No	No	0	8	9
275	R:R:H134	R:R:N137	2.55	No	No	0	4	4
276	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	2
277	R:R:F38	R:R:I77	2.51	Yes	No	0	7	6
278	R:R:F40	R:R:I39	2.51	No	No	0	6	5
279	R:R:K60	R:R:R63	2.48	No	No	0	7	7
280	R:R:F21	R:R:R270	2.14	Yes	No	0	2	1
281	R:R:G172	R:R:G173	2.11	No	No	0	3	4
282	R:R:R210	R:R:W213	2	Yes	No	0	4	3
283	R:R:A122	R:R:C207	1.81	No	No	0	9	8
284	R:R:G41	R:R:I77	1.76	No	No	0	8	6
285	R:R:G157	R:R:I156	1.76	No	No	0	5	4
286	R:R:G44	R:R:L43	1.71	No	No	0	7	4
287	R:R:G202	R:R:L201	1.71	No	Yes	0	3	7
288	R:R:A237	R:R:S208	1.71	No	No	0	7	8
289	R:R:C243	R:R:V239	1.71	No	No	0	8	7
290	R:R:A108	R:R:T159	1.68	No	No	0	4	7
291	R:R:K225	R:R:P299	1.67	No	No	0	5	5
292	R:R:A237	R:R:M234	1.61	No	No	0	7	4
293	R:R:V235	R:R:V293	1.6	No	No	0	5	8
294	R:R:V249	R:R:V250	1.6	No	No	0	6	5
295	R:R:H131	R:R:P132	1.53	Yes	No	0	7	8
296	R:R:K28	R:R:V29	1.52	No	No	0	3	5
297	R:R:F38	R:R:G35	1.51	Yes	No	0	7	5
298	R:R:L30	R:R:V29	1.49	No	No	0	5	5
299	R:R:L201	R:R:V241	1.49	Yes	No	0	7	5
300	R:R:L245	R:R:V241	1.49	No	No	0	6	5
301	R:R:L289	R:R:V292	1.49	No	No	0	7	6
302	R:R:I238	R:R:I242	1.47	No	No	0	5	5
303	R:R:A135	R:R:H134	1.46	No	No	0	5	4
304	R:R:A224	R:R:H223	1.46	No	No	0	3	4
305	R:R:I154	R:R:L151	1.43	No	Yes	0	5	7
306	R:R:I154	R:R:L158	1.43	No	No	0	5	5
307	R:R:L102	R:R:M106	1.41	No	No	0	5	5
308	R:R:C53	R:R:F67	1.4	No	Yes	0	4	6
309	R:R:K138	R:R:N137	1.4	No	No	0	4	4
310	R:R:R142	R:R:S140	1.32	No	No	0	4	6
311	R:R:N175	R:R:Q170	1.32	No	No	0	4	1
312	R:R:F232	R:R:T231	1.3	No	No	0	7	6
313	R:R:D8	R:R:H9	1.26	No	No	0	6	6
314	R:R:K166	R:R:R101	1.24	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F21	5.22	4	0	2
2	R:R:F38	7.0525	4	0	7
3	R:R:F67	6.1975	4	0	6
4	R:R:D73	7.236	5	2	9
5	R:R:Y87	9.164	5	1	6
6	R:R:W91	8.56571	7	1	4
7	R:R:W93	8.61429	7	3	9
8	R:R:F95	8.866	5	3	7
9	R:R:F105	6.2925	4	7	6
10	R:R:M109	6.822	5	7	5
11	R:R:N110	7.625	4	0	9
12	R:R:R111	7.5825	4	1	8
13	R:R:Q112	6.142	5	0	7
14	R:R:Y126	9.235	6	4	7
15	R:R:F127	7.35	5	4	5
16	R:R:V130	6.596	5	4	8
17	R:R:H131	5.0225	4	4	7
18	R:R:L151	4.425	4	0	7
19	R:R:M167	4.085	4	0	3
20	R:R:F180	9.54833	6	1	3
21	R:R:H189	12.4625	4	1	5
22	R:R:E190	10.065	4	0	4
23	R:R:F193	7.1775	4	0	6
24	R:R:F197	7.975	4	0	8
25	R:R:L201	3.208	5	0	7
26	R:R:R210	7.6175	4	4	4
27	R:R:F244	8.4025	4	0	8
28	R:R:R251	10.7125	4	0	5
29	R:R:Y269	3.588	5	0	2
30	R:R:T283	6.3275	4	1	8
31	R:R:Y284	5.48	5	1	7
32	R:R:D290	7.564	5	2	9
33	R:R:Y294	6.72	7	2	9
34	R:R:Y295	5.0475	4	0	7
35	R:R:F301	5.585	4	0	9
36	L:L:?1	8.33889	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D273	R:R:F21	33.0009	7.17	No	Yes	0	4	2
2	R:R:D273	R:R:I182	36.3923	9.8	No	No	0	4	3
3	R:R:I182	R:R:I254	40.0484	4.42	No	No	0	3	4
4	R:R:I254	R:R:R251	47.3424	6.26	No	Yes	0	4	5
5	R:R:E190	R:R:R251	17.2285	16.28	Yes	Yes	0	4	5
6	R:R:E190	R:R:F180	40.8609	7	Yes	Yes	0	4	3
7	L:L:?1	R:R:F180	88.1713	5.23	Yes	Yes	1	0	3
8	L:L:?1	R:R:W91	20.5377	5.87	Yes	Yes	1	0	4
9	R:R:F193	R:R:R251	20.0584	6.41	Yes	Yes	0	6	5
10	R:R:F180	R:R:F193	22.0987	11.79	Yes	Yes	0	3	6
11	R:R:F276	R:R:R251	16.4297	13.9	No	Yes	0	4	5
12	R:R:F180	R:R:F276	25.0063	5.36	Yes	No	0	3	4
13	L:L:?1	R:R:L104	17.0733	5.94	Yes	No	0	0	5
14	R:R:E190	R:R:Q187	22.6647	7.65	Yes	No	0	4	2
15	R:R:Q187	R:R:T185	21.5693	7.09	No	No	0	2	2
16	R:R:L258	R:R:Y269	15.3616	3.52	No	Yes	0	3	2
17	R:R:H259	R:R:L258	16.6123	5.14	No	No	0	1	3
18	R:R:H184	R:R:H259	17.8584	9.55	No	No	0	3	1
19	R:R:H184	R:R:T185	19.0999	8.21	No	No	0	3	2
20	R:R:D23	R:R:D24	14.7682	6.65	No	No	0	4	4
21	R:R:D23	R:R:F21	18.4495	4.78	No	Yes	0	4	2
22	R:R:D24	R:R:F25	11.0825	22.69	No	No	0	4	6
23	L:L:?1	R:R:Y284	36.2576	9.06	Yes	Yes	1	0	7
24	L:L:?1	R:R:L107	40.2903	10.7	Yes	No	0	0	6
25	R:R:L107	R:R:L76	40.1739	4.15	No	No	0	6	7
26	R:R:L76	R:R:S287	39.4733	6.01	No	No	0	7	8
27	R:R:D73	R:R:S287	39.3318	10.31	Yes	No	0	9	8
28	R:R:D290	R:R:D73	38.1062	11.98	Yes	Yes	2	9	9
29	R:R:D290	R:R:Y294	100	6.9	Yes	Yes	2	9	9
30	R:R:L66	R:R:Y294	95.6706	4.69	No	Yes	0	8	9
31	R:R:L66	R:R:Y295	94.9586	7.03	No	Yes	0	8	7
32	R:R:F52	R:R:Y295	92.2701	5.16	No	Yes	0	7	7
33	R:R:F301	R:R:F52	74.6057	4.29	Yes	No	0	9	7
34	L:L:?1	R:R:R111	39.6079	11.47	Yes	Yes	1	0	8
35	R:R:R111	R:R:T283	29.096	7.76	Yes	Yes	1	8	8
36	R:R:F244	R:R:T283	60.9124	5.19	Yes	Yes	0	8	8
37	R:R:F244	R:R:N286	69.7857	10.87	Yes	No	0	8	9
38	R:R:D290	R:R:N286	67.6427	8.08	Yes	No	0	9	9
39	R:R:T283	R:R:Y284	33.2109	4.99	Yes	Yes	1	8	7
40	R:R:F240	R:R:L201	10.1696	3.65	No	Yes	0	9	7
41	R:R:F240	R:R:F244	11.9451	7.5	No	Yes	0	9	8
42	R:R:F52	R:R:F67	22.3954	7.5	No	Yes	0	7	6
43	R:R:F67	R:R:W59	16.3453	8.02	Yes	No	0	6	6
44	R:R:I64	R:R:W59	10.149	5.87	No	No	0	7	6
45	R:R:H134	R:R:N137	12.292	2.55	No	No	0	4	4
46	R:R:F127	R:R:H134	17.1988	12.44	Yes	No	0	5	4
47	R:R:F127	R:R:Y126	12.2943	5.16	Yes	Yes	4	5	7
48	R:R:V130	R:R:Y126	16.8222	12.62	Yes	Yes	4	8	7
49	R:R:V129	R:R:V130	38.4029	3.21	No	Yes	0	8	8
50	R:R:L215	R:R:V129	44.768	2.98	No	No	0	8	8
51	R:R:L215	R:R:M220	51.3956	4.24	No	No	0	8	3
52	R:R:I226	R:R:M220	54.634	4.37	No	No	0	6	3
53	R:R:H223	R:R:I226	55.7044	6.63	No	No	0	4	6
54	R:R:H223	R:R:K225	57.8314	10.48	No	No	0	4	5
55	R:R:K225	R:R:P299	58.6804	1.67	No	No	0	5	5
56	R:R:P299	R:R:S298	63.7059	5.34	No	No	0	5	8
57	R:R:S298	R:R:S300	64.7352	4.89	No	No	0	8	5
58	R:R:F301	R:R:S300	65.7599	2.64	Yes	No	0	9	5
59	R:R:F127	R:R:H131	12.2281	6.79	Yes	Yes	4	5	7
60	R:R:H131	R:R:V130	15.8295	4.15	Yes	Yes	4	7	8
61	R:R:E196	R:R:R111	11.8219	6.98	No	Yes	0	5	8
62	R:R:E196	R:R:Q112	14.3848	10.19	No	Yes	0	5	7
63	R:R:M103	R:R:W93	19.424	4.65	No	Yes	0	5	9
64	R:R:F95	R:R:W93	16.5119	12.03	Yes	Yes	3	7	9
65	R:R:L107	R:R:M103	13.6522	4.24	No	No	0	6	5
66	R:R:N175	R:R:W93	12.874	5.65	No	Yes	0	4	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R22	R:R:W91	12	0	No	Yes	3	4	2	1
R:R:L30	R:R:Y87	7.03	0	No	Yes	5	6	2	1
R:R:L107	R:R:L76	4.15	0	No	No	6	7	1	2
R:R:L80	R:R:Y284	5.86	0	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	14.07	1	No	Yes	6	6	1	1
R:R:L83	R:R:M103	5.65	1	No	No	6	5	1	2
L:L:?1	R:R:L83	7.13	1	Yes	No	0	6	0	1
R:R:N86	R:R:W91	5.65	0	No	Yes	5	4	2	1
R:R:W91	R:R:Y87	12.54	1	Yes	Yes	4	6	1	1
R:R:F277	R:R:Y87	4.13	1	No	Yes	5	6	2	1
L:L:?1	R:R:Y87	8.05	1	Yes	Yes	0	6	0	1
R:R:L176	R:R:W91	5.69	0	No	Yes	4	4	2	1
R:R:S178	R:R:W91	6.18	0	No	Yes	4	4	2	1
R:R:F277	R:R:W91	12.03	1	No	Yes	5	4	2	1
L:L:?1	R:R:W91	5.87	1	Yes	Yes	0	4	0	1
R:R:L107	R:R:M103	4.24	0	No	No	6	5	1	2
R:R:L104	R:R:M167	4.24	0	No	Yes	5	3	1	2
R:R:C177	R:R:L104	4.76	3	No	No	9	5	2	1
L:L:?1	R:R:L104	5.94	1	Yes	No	0	5	0	1
L:L:?1	R:R:L107	10.7	1	Yes	No	0	6	0	1
R:R:E196	R:R:R111	6.98	0	No	Yes	5	8	2	1
R:R:R111	R:R:T283	7.76	1	Yes	Yes	8	8	1	2
R:R:R111	R:R:Y284	4.12	1	Yes	Yes	8	7	1	1
L:L:?1	R:R:R111	11.47	1	Yes	Yes	0	8	0	1
R:R:F180	R:R:S179	5.28	1	Yes	No	3	4	1	1
R:R:H189	R:R:S179	9.76	1	Yes	No	5	4	2	1
L:L:?1	R:R:S179	11.6	1	Yes	No	0	4	0	1
R:R:F180	R:R:H189	22.63	1	Yes	Yes	3	5	1	2
R:R:E190	R:R:F180	7	0	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	11.79	1	Yes	Yes	3	6	1	2
R:R:F180	R:R:F276	5.36	1	Yes	No	3	4	1	2
L:L:?1	R:R:F180	5.23	1	Yes	Yes	0	3	0	1
R:R:T283	R:R:Y284	4.99	1	Yes	Yes	8	7	2	1
L:L:?1	R:R:Y284	9.06	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IZC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.03
Number of Linked Nodes	281
Number of Links	314
Number of Hubs	36
Number of Links mediated by Hubs	145
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	82484
Length Of Smallest Path	3
Average Path Length	17.1751
Length of Longest Path	40
Minimum Path Strength	1.43
Average Path Strength	6.70366
Maximum Path Strength	16.66
Minimum Path Correlation	0.7
Average Path Correlation	0.916592
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	37.3779
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.9374
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • myeloid cell apoptotic process • multicellular organismal process • homeostatic process • leukocyte apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • homeostasis of number of cells • apoptotic process • myeloid cell homeostasis • programmed cell death • positive regulation of cell communication • system process • regulation of adiponectin secretion • positive regulation of establishment of protein localization • positive regulation of adiponectin secretion • adiponectin secretion • endocrine hormone secretion • positive regulation of multicellular organismal process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • positive regulation of secretion • regulation of multicellular organismal process • positive regulation of protein secretion • endocrine process • positive regulation of transport • positive regulation of signaling • regulation of programmed cell death • regulation of neutrophil apoptotic process • positive regulation of myeloid cell apoptotic process • positive regulation of neutrophil apoptotic process • regulation of immune system process • positive regulation of leukocyte apoptotic process • positive regulation of immune system process • regulation of leukocyte apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • positive regulation of apoptotic process • regulation of myeloid cell apoptotic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XOT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XOT
Name	(4aR,5aR)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid
Synonyms	MK 1903
Identifier
Formula	C8 H8 N2 O2
Molecular Weight	164.161
SMILES
PubChem	49763030
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	2
Total Bonds	22
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDS4
Sequence	>9IZC_nogp_Chain_R D H F L E I D K K N C C V F R D D F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R W D W K F G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N R T A A I I S C L L W G I T I G L T V H L L K K K M P I Q N G G A N L C S S F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JHY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n	Gi1/β1/γ2	2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JHY (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	Compound 9n		2.87	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JII (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		3.17	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8J6P	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n	Gi1/β1/γ2	2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6P (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	Compound 9n		2.55	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n	Gi1/β1/γ2	2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6Q (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	β-Hydroxybutyrate	Compound 9n		2.6	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8UTD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UTD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK1903	-		3.24	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-	Gi1/β1/γ2	2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8UUJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Mus musculus	FCH-2296413	-		2.62	2025-02-26	doi.org/10.1016/j.cell.2024.11.001
	8J6J	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6J (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.8	2024-01-10	doi.org/10.1016/j.celrep.2023.113406
	8J6I	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6I (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.92	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8J6L (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.05	2024-04-03	doi.org/10.1016/j.celrep.2023.113406
	8JIL	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIL (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.5	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Gi1/β1/γ2	2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JIM (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		2.98	2023-09-06	doi.org/10.1016/j.molcel.2023.07.030
	8JZ7	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8JZ7 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.6	2023-10-04	doi.org/10.1038/s41392-023-01625-y
	8IJ3	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	Gi1/β1/γ2	3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJ3 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-		3.28	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		2.69	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.23	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	8IJD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.25	2024-01-03	doi.org/10.1038/s41421-023-00610-7
	7XK2	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7XK2 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.1	2023-02-22	doi.org/10.1038/s41467-023-37177-6
	7ZL9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	7ZLY	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	-	-	-	2.7	2023-04-12	doi.org/10.1038/s41467-023-37177-6
	8IHF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.97	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-	Gi1/β1/γ2	3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	LUF6283	-		3.06	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHI (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acifran	-		3.11	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHB	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8IHB (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		2.85	2023-09-13	doi.org/10.1038/s41467-023-41650-7
	8K5B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	-	3.43	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5C	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	-	3.13	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8K5D	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	-	3.74	2023-11-22	doi.org/10.1038/s41467-023-42764-8
	8I7V	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Gi1/β1/γ2	2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7V (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		2.77	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Gi1/β1/γ2	3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8I7W (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.39	2024-02-07	doi.org/10.1038/s41467-023-42764-8
	8J6R	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Gi1/β1/γ2	2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8J6R (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		2.76	2023-12-06	doi.org/10.1038/s41467-023-43537-z
	8IY9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Go/β1/γ2	3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IY9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.37	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-	Go/β1/γ2	3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYH (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MK6892	-		3.3	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8IYW (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	GSK256073	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-	Go/β1/γ2	3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JER (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Acipimox	-		3.45	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-	Go/β1/γ2	3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	8JHN (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	MMF	-		3.75	2024-03-06	doi.org/10.1038/s41467-024-46239-2
	9CIB	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Mus musculus	FCH-2296413	-	-	2.62	2025-05-14	doi.org/10.1016/j.cell.2024.11.001
	9IQT	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	9IQT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	Niacin	-		2.9	2024-10-02	doi.org/10.1016/j.jmb.2024.168795
	8H2G	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-	Gi1/β1/γ2	3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	8H2G (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₂	Homo sapiens	Niacin	-		3.01	2023-10-11	doi.org/10.1038/s41467-023-42764-8
	9IZA	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-	Gi1/β1/γ2	3.06	2025-04-02	To be published
	9IZA (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	SCH900271	-		3.06	2025-04-02	To be published
	9IZC	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-	Gi1/β1/γ2	2.68	2025-04-02	To be published
	9IZC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic acid	HCA₂	Homo sapiens	MK1903	-		2.68	2025-04-02	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9IZC_nogp.zip

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